MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Pigment Cell and Melanoma Research' source. Tue, 07 Feb 2012 08:49:01 +0100 http://www.medworm.com/index.php?rid=5636839&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22273393%26dopt%3DAbstract Authors: Teh JL, Chen S Abstract The role of the glutamatergic system in cancer cell homeostasis has expanded exponentially over the last decade. Once thought to participate only in synaptic transmission and neuronal excitability, the presence of functional glutamate receptors have since been demonstrated in peripheral tissues. Most notable is the implication of glutamate receptors in the pathophysiology of various human malignancies. We previously described the oncogenic properties of metabotropic glutamate receptor 1 (Grm1), a G-protein coupled receptor in melanoma development in vivo. TG-3, a transgenic mouse line developed spontaneous melanoma with 100% penetrance in the absence of any known stimuli. Stable Grm1-mouse melanocytic clones display transformed phenotypes in vitro a... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5636839 Tue, 24 Jan 2012 05:00:00 +0100 5636839 http://www.medworm.com/index.php?rid=5626292&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22268848%26dopt%3DAbstract This article will review the genetic findings in uveal melanoma over the past two decades and suggest important areas for future work. © 2012 John Wiley & Sons A/S. PMID: 22268848 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5626292 Mon, 23 Jan 2012 05:00:00 +0100 5626292 http://www.medworm.com/index.php?rid=5626291&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22268896%26dopt%3DAbstract Authors: Kim HK, Chanock SJ PMID: 22268896 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5626291 Mon, 23 Jan 2012 05:00:00 +0100 5626291 http://www.medworm.com/index.php?rid=5618306&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22260482%26dopt%3DAbstract Authors: Walia V, Mu EW, Lin JC, Samuels Y Abstract Melanoma, the most aggressive form of skin cancer, has increased in incidence more rapidly than any other cancer. The completion of the human genome project and advancements in genomics technologies has allowed us to investigate genetic alterations of melanoma at a scale and depth that is unprecedented. Here, we survey the history of the different approaches taken to understand the genomics of melanoma - from early candidate genes, to gene families, to genome wide studies. The new era of whole exome and whole genome sequencing has paved the way for an in depth understanding of melanoma biology, identification of new therapeutic targets and development of novel personalized therapies for melanoma. PMID: 22260482 [PubMed - as su... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5618306 Thu, 19 Jan 2012 05:00:00 +0100 5618306 http://www.medworm.com/index.php?rid=5618305&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22260517%26dopt%3DAbstract Authors: Das A, Pushparaj C, Bahí N, Sorolla A, Herreros J, Pamplona R, Vilella R, Matias-Guiu X, Martí RM, Cantí C Abstract The expression of voltage-gated calcium channels (VGCCs) has not been reported previously in melanoma cells, in spite of the increasing evidences for a role of VGCCs in tumorigenesis and tumour progression. To address this issue we have performed an extensive RT-PCR analysis of VGCCs expression in human melanocytes and a range of melanoma cell lines and biopsies. In addition, we have tested the functional expression of these channels upon application of Ca(2+) imaging techniques, and examined their relevance in the viability and proliferation of the melanoma cells. Our results show that control melanocytes and melanoma cells express channel isoforms belong... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5618305 Thu, 19 Jan 2012 05:00:00 +0100 5618305 http://www.medworm.com/index.php?rid=5618307&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22252091%26dopt%3DAbstract Authors: Colanesi S, Taylor KL, Temperley ND, Lundegaard PR, Liu D, North TE, Ishizaki H, Kelsh RN, Patton EE Abstract Small molecules complement genetic mutants and can be used to probe pigment cell biology by inhibiting specific proteins or pathways. Here, we present the results of a screen of active compounds for those that affect the processes of melanocyte and iridophore development in zebrafish, and investigate the effects of a few of these compounds in further detail. We identified and confirmed 57 compounds that altered pigment cell patterning, number, survival or differentiation. Additional tissue targets and toxicity of small molecules are also discussed. Given that the majority of cell types, including pigment cells, are conserved between zebrafish and other vertebrates,... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5618307 Tue, 17 Jan 2012 05:00:00 +0100 5618307 http://www.medworm.com/index.php?rid=5618308&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22248438%26dopt%3DAbstract This article will review the catalog of mutations identified in melanoma through a variety of approaches, including the use of unbiased exome and whole-genome next generation sequencing platforms, as well discuss complementary strategies for identifying driver mutations. The promise of personalised medicine afforded by better understanding these mutation events should provide impetus for increased activity and rapid advances in this field. PMID: 22248438 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5618308 Mon, 16 Jan 2012 05:00:00 +0100 5618308 http://www.medworm.com/index.php?rid=5595118&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22236408%26dopt%3DAbstract This study shows that elevated sphingosine-1-phosphate (S-1-P) levels resulting from increased activity of sphingosine kinase-1 (SPHK1) occur in advanced melanomas. Targeting SPHK1 using siRNA decreased anchorage dependent and independent growth as well as sensitized melanoma cells to apoptosis inducing agents. Pharmacological SPHK1 inhibitors SKI-I but not SKI-II decreased S-1-P content, elevated ceramide levels, caused a G2-M block and induced apoptotic cell death in melanomas. Targeting SPHK1 using siRNA or the pharmacological agent called SKI-I, decreased the levels of pAKT. Furthermore, SKI-I inhibited the expression of CYCLIN D1 protein and increased the activity of caspase-3/7, which in turn led to the degradation of PARP. In animals, SKI-I but not SKI-II retarded melanoma growth by... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5595118 Wed, 11 Jan 2012 05:00:00 +0100 5595118 http://www.medworm.com/index.php?rid=5595116&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22236444%26dopt%3DAbstract We report the mutation status of relevant melanoma genes, expression levels of proteins of interest and DNA fingerprinting of a panel of uveal melanoma cell lines used in the research community. PMID: 22236444 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5595116 Wed, 11 Jan 2012 05:00:00 +0100 5595116 http://www.medworm.com/index.php?rid=5579211&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22233237%26dopt%3DAbstract Authors: Herlyn M PMID: 22233237 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5579211 Tue, 10 Jan 2012 05:00:00 +0100 5579211 http://www.medworm.com/index.php?rid=5579212&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22225770%26dopt%3DAbstract Authors: Yang XR, Brown K, Landi MT, Ghiorzo P, Badenas C, Xu M, Hayward NK, Calista D, Landi G, Bruno W, Bianchi-Scarrà G, Aguilera P, Puig S, Goldstein AM, Tucker MA Abstract Copy number variations (CNVs) have been shown to contribute substantially to disease susceptibility in several inherited diseases including cancer. We conducted a genome-wide search for CNVs in blood-derived DNA from 79 individuals (62 melanoma patients and 17 spouse controls) of 30 high-risk melanoma-prone families without known segregating mutations using genome-wide comparative genomic hybridization (CGH) tiling arrays. We identified a duplicated region on chromosome 4q13 in germline DNA of all melanoma patients in a melanoma-prone family with three affected siblings. We confirmed the duplication using q... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5579212 Mon, 09 Jan 2012 05:00:00 +0100 5579212 http://www.medworm.com/index.php?rid=5579213&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22221910%26dopt%3DAbstract Authors: Scholz M, Stankovic G, Scholz C, Leupold D, Buder S, Kohl P, Eichhorn R, Stücker M, Hoffmann K PMID: 22221910 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5579213 Thu, 05 Jan 2012 05:00:00 +0100 5579213 http://www.medworm.com/index.php?rid=5570523&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22212396%26dopt%3DAbstract Authors: Jewell R, Mitra A, Conway C, Iremonger J, Walker C, de Kort F, Cook M, Boon A, Speirs V, Newton-Bishop J PMID: 22212396 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5570523 Fri, 23 Dec 2011 05:00:00 +0100 5570523 http://www.medworm.com/index.php?rid=5521970&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22176508%26dopt%3DAbstract Authors: Arnheiter H PMID: 22176508 [PubMed - in process] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5521970 Wed, 21 Dec 2011 01:23:40 +0100 5521970 http://www.medworm.com/index.php?rid=5513688&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22171919%26dopt%3DAbstract Authors: Li W, Song L, Ritchie AM, Melton DW Abstract The mitogen activated protein kinase (MAPK) pathway is important in melanoma. In this pathway, DUSP6 phosphatase negatively controls activation of ERK kinase. Through comparison of melanoma signalling pathways between immortal mouse melanocytes and their tumourigenic derivatives, retrieved from mouse xenografts, we identified a molecularly distinct subtype of melanoma, characterized by reduced ERK activity and increased DUSP6 expression. Overexpression of DUSP6 enhanced anchorage-independent growth and invasive ability of immortal mouse melanocytes, suggesting that increased DUSP6 expression contributes to melanoma formation in the mouse xenografts. In contrast, reduced tumourigenicity was observed after DUSP6 overexpression in ... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5513688 Thu, 15 Dec 2011 05:00:00 +0100 5513688 http://www.medworm.com/index.php?rid=5513687&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22171948%26dopt%3DAbstract Authors: Deng W, Yennu-Nanda VG, Scott A, Chen G, Woodman SE, Davies MA Abstract BRAF inhibition is highly active in BRAF-mutant melanoma, but the degree and duration of responses is quite variable. Improved understanding of the mechanisms of de novo resistance may lead to rational therapeutic strategies with improved efficacy. Proteomic analysis of BRAF-mutant, PTEN-wild-type human melanoma cell lines treated with PLX4720 demonstrated that sensitive and de novo resistant lines exhibit similar RAS-RAF-MEK-ERK pathway inhibition, but the resistant cells exhibited durable activation of S6 and P70S6K. Treatment with the mTOR inhibitor rapamycin blocked activation of P70S6K and S6, but it also increased activation of AKT and failed to induce cell death. Combined treatment with rapamyci... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5513687 Thu, 15 Dec 2011 05:00:00 +0100 5513687 http://www.medworm.com/index.php?rid=5502657&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22145962%26dopt%3DAbstract Authors: Wendt J, Schanab O, Binder M, Pehamberger H, Okamoto I Abstract Sun exposure is causal for melanoma but is subject to bias of recall so that it is difficult to dissect the role of particular patterns of sun exposure. In this hospital-based case-control study (n=1991), we aimed to analyze pigmentation traits and signs of actinic damage at different anatomic locations as markers of melanoma risk in central European patients. Although all signs of actinic damage (freckling, wrinkling and solar lentigos) were significantly associated with melanoma risk in multivariate logistic regression models adjusting for age and sex, the strongest associations were observed for the dorsal parts of the body: adjusted odds ratios [OR] were 4.22 for wrinkling on the neck, 3.43 for solar lenti... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5502657 Tue, 06 Dec 2011 05:00:00 +0100 5502657 http://www.medworm.com/index.php?rid=5502656&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22145991%26dopt%3DAbstract Authors: Wong RP, Aguissa-Touré AH, Wani AA, Khosravi S, Martinka M, Martinka M, Li G Abstract The E3 ligase Rad18 is a key regulator for the lesion bypass pathway which plays an important role in genomic stability. However, the status of Rad18 expression in melanoma is not known. Using melanoma tissue microarray (TMA), we showed that nuclear Rad18 expression was upregulated in primary and metastatic melanoma compared to dysplastic nevi. Rad18 expression was significantly reduced in sun-exposed sites compared to the sun-protected sites. Strong Rad18 expression correlated with worse 5-year patient survival and was an independent prognostic factor for melanoma found in the sun-protected sites. Furthermore, we showed that melanoma cell proliferation and the expression of pAkt and cyc... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5502656 Tue, 06 Dec 2011 05:00:00 +0100 5502656 http://www.medworm.com/index.php?rid=5502658&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22136309%26dopt%3DAbstract Authors: Kotobuki Y, Tanemura A, Yang L, Itoi S, Wataya-Kaneda M, Murota H, Fujimoto M, Serada S, Naka T, Katayama I Abstract The aim of this study was to show CD4(+) IL-17A(+) Th17 cells infiltrate into vitiligo skin and to investigate whether the proinflammatory cytokines related to Th17 cells influence the melanocyte enzymatic activity and cell fate. An immunohistochemical analysis showed Th17 cells infiltration in 7 of 23 vitiligo skin samples in addition to CD8(+) cells on the reticular dermis. An in vitro analysis showed the expression of MITF and downstream genes to be downregulated by the treatment with IL-17A, IL-1β, IL-6 and TNF-α. The treatment with these cytokines also induced morphological shrinking in melanocyte, resulting in a decreased melanin production. In view ... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5502658 Sat, 03 Dec 2011 05:00:00 +0100 5502658 http://www.medworm.com/index.php?rid=5570522&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22216435%26dopt%3DAbstract Authors: Tew KD PMID: 22216435 [PubMed - in process] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5570522 Thu, 01 Dec 2011 05:00:00 +0100 5570522 http://www.medworm.com/index.php?rid=5570521&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22216437%26dopt%3DAbstract Authors: Yeh ET PMID: 22216437 [PubMed - in process] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5570521 Thu, 01 Dec 2011 05:00:00 +0100 5570521 http://www.medworm.com/index.php?rid=5570520&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22216441%26dopt%3DAbstract Authors: Harbour JW PMID: 22216441 [PubMed - in process] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5570520 Thu, 01 Dec 2011 05:00:00 +0100 5570520 http://www.medworm.com/index.php?rid=5570519&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22216442%26dopt%3DAbstract Authors: PMID: 22216442 [PubMed - in process] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5570519 Thu, 01 Dec 2011 05:00:00 +0100 5570519 http://www.medworm.com/index.php?rid=5570518&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22216444%26dopt%3DAbstract Authors: Admon A PMID: 22216444 [PubMed - in process] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5570518 Thu, 01 Dec 2011 05:00:00 +0100 5570518 http://www.medworm.com/index.php?rid=5570517&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22216451%26dopt%3DAbstract Authors: Walker G PMID: 22216451 [PubMed - in process] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5570517 Thu, 01 Dec 2011 05:00:00 +0100 5570517 http://www.medworm.com/index.php?rid=5466851&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22107814%26dopt%3DAbstract Authors: Ronai Z PMID: 22107814 [PubMed - in process] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5466851 Thu, 01 Dec 2011 05:00:00 +0100 5466851 http://www.medworm.com/index.php?rid=5466850&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22107815%26dopt%3DAbstract Authors: PMID: 22107815 [PubMed - in process] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5466850 Thu, 01 Dec 2011 05:00:00 +0100 5466850 http://www.medworm.com/index.php?rid=5466846&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22128787%26dopt%3DAbstract Carcinogen treatment in mouse selectively expressing activated N-Ras(Q61K) in melanocytes recapitulates metastatic cutaneous melanoma development. Pigment Cell Melanoma Res. 2011 Nov 29; Authors: Contassot E, Jankovic D, Schuler P, Preynat-Seauve O, Kerl K, Beermann F, French LE Abstract The incidence of melanoma has significantly increased and a better understanding its pathogenesis and development of new therapeutic strategies are urgently needed. Here we describe a murine model of metastatic cutaneous melanoma using C57BL/6 mice expressing a mutated human N-Ras gene under the control of a tyrosinase promoter (TyrRas). These mice were topically exposed to 7,12- dimethylbenzanthracene (DMBA) for brief exposure periods. Cutaneous melanoma developed at the site of exposure o... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5466846 Tue, 29 Nov 2011 05:00:00 +0100 5466846 http://www.medworm.com/index.php?rid=5466848&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22117610%26dopt%3DAbstract Authors: D'Osualdo A, Reed JC Abstract Some familial forms of the dermatological condition vitiligo have recently been linked to polymorphisms in the innate immunity gene, NLRP1. Here we review what is currently known about the mechanisms that regulate activation of the NLRP1 protein and the downstream effects of NLRP1 on pathways impacting inflammation and apoptosis. How polymorphic variants of the NLRP1 gene contribute to the pathogenesis of vitiligo remains mysterious, requiring further investigation. PMID: 22117610 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5466848 Fri, 25 Nov 2011 05:00:00 +0100 5466848 http://www.medworm.com/index.php?rid=5466847&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22117673%26dopt%3DAbstract Authors: Smalley KS, Aplin AE, Flaherty KT, Hoeller C, Bosserhoff AK, Haass NK, Bosenberg M, Ribas A, Barnhill R, Kudchadkar R, Messina JL Abstract The 2011, 8(th) International Congress of the Society for Melanoma Research was held in conjunction with the 5(th) Meeting of the Interdisciplinary Melanoma/Skin Cancer Centres, the 2(nd) Melanoma update for Primary Care Physicians, Surgeons, Oncologists and Dermatologists and the 4(th) Melanoma Pathology Symposium of the International Melanoma Pathology Working Group in Tampa, Florida, USA. The four meetings attracted over 685 attendees and covered the breadth of basic melanoma biology all the way through to the clinical management of melanoma and other skin cancers. The major focus of discussions this year was upon the resistance of m... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5466847 Fri, 25 Nov 2011 05:00:00 +0100 5466847 http://www.medworm.com/index.php?rid=5466849&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22111984%26dopt%3DAbstract Authors: Bennett DC PMID: 22111984 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5466849 Wed, 23 Nov 2011 05:00:00 +0100 5466849 http://www.medworm.com/index.php?rid=5466852&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22099450%26dopt%3DAbstract Authors: Taïeb A PMID: 22099450 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5466852 Sat, 19 Nov 2011 05:00:00 +0100 5466852 http://www.medworm.com/index.php?rid=5419839&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22085368%26dopt%3DAbstract Authors: Berlin I, Luciani F, Gallagher SJ, Rambow F, Conde-Perez A, Colombo S, Champeval D, Delmas V, Larue L PMID: 22085368 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5419839 Wed, 16 Nov 2011 05:00:00 +0100 5419839 http://www.medworm.com/index.php?rid=5419838&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22085392%26dopt%3DAbstract Authors: Newton-Bishop J PMID: 22085392 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5419838 Wed, 16 Nov 2011 05:00:00 +0100 5419838 http://www.medworm.com/index.php?rid=5378363&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22026648%26dopt%3DAbstract Authors: Yoshikawa T, Mizuno A, Yasumuro H, Inami W, Vergara MN, Del Rio-Tsonis K, Chiba C Abstract The onset mechanism of proliferation in mitotically quiescent retinal pigment epithelium (RPE) cells is still obscure in humans and newts, although it can be a clinical target for manipulating both retinal diseases and regeneration. To address this issue, we investigated factors or signalling pathways involved in the first cell-cycle entry of RPE cells upon retinal injury using a newt retina-less eye-cup culture system in which the cells around the wound edge of the RPE exclusively enter the cell-cycle. We found that MEK-ERK signaling is necessary for their cell-cycle entry, and signalling pathways whose activities can be modulated by heparin, such as Wnt-, Shh- and thrombin-mediated... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5378363 Tue, 25 Oct 2011 04:00:00 +0100 5378363 http://www.medworm.com/index.php?rid=5378365&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22018309%26dopt%3DAbstract Authors: Peeper DS Abstract In recent years, many groups have detected biomarkers of cellular senescence in a plethora of neoplastic lesions, in model systems and humans. Indeed, we have come to realize that oncogene-induced senescence (OIS) acts as a potent barrier to oncogenic transformation, operating alongside cell death programs. We have begun to uncover some of its underlying principles, but many fundamental questions remain. In this perspective, some of the "knowns" and "unknowns" of OIS are discussed, with a focus on melanomagenesis. PMID: 22018309 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5378365 Sat, 22 Oct 2011 04:00:00 +0100 5378365 http://www.medworm.com/index.php?rid=5378369&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22004131%26dopt%3DAbstract Authors: Price MA, Wanshura LE, Yang J, Carlson J, Xiang B, Li G, Ferrone S, Dudek AZ, Turley EA, McCarthy JB Abstract Chondroitin sulfate proteoglycan 4 (CSPG4), a transmembrane proteoglycan originally identified as a highly immunogenic tumor antigen on the surface of melanoma cells, is associated with melanoma tumor formation and poor prognosis in certain melanomas and several other tumor types. The complex mechanisms by which CSPG4 affects melanoma progression have started to be defined, in particular the association with other cell surface proteins and receptor tyrosine kinases and its central role in modulating the function of these proteins. CSPG4 is essential to the growth of melanoma tumors through its modulation of integrin function, and enhanced growth factor receptor-reg... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5378369 Mon, 17 Oct 2011 04:00:00 +0100 5378369 http://www.medworm.com/index.php?rid=5378367&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22004179%26dopt%3DAbstract Authors: Bell RE, Levy C Abstract Studies examining intratumor heterogeneity have indicated that several cancer types, including melanoma, can display phenotypic plasticity, corresponding to their capacity to undergo transient reversible cellular changes. Conceptual models constructed to explain the process of cancer propagation differ in their treatment of intratumor heterogeneity. Recent observations of reversible phenotypic heterogeneity in melanoma,haveled the proposal ofa novel 'phenotypic plasticity' model of cancer propagation. Microphthalmia-associated transcription factor (MITF), the melanocyte 'lineage-specific' transcription factor, has emerged as one of the central players in melanoma phenotypic plasticity.Here we discuss the conceptual models proposed to explain the re... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5378367 Mon, 17 Oct 2011 04:00:00 +0100 5378367 http://www.medworm.com/index.php?rid=5378371&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21995431%26dopt%3DAbstract Authors: Checinska A, Soengas MS Abstract True to their inherent aggressive behavior, melanomas keep impressing the melanoma community by their ability to bypass tumor suppressor mechanisms. Name a pathway with the potential to control cell survival, and melanoma cells will likely have it potentiated by multiple genetic or epigenetic alterations. In the context of progression and chemoresistance, large efforts have been dedicated to the identification of protective mechanisms associated with or linked to apoptotic death programs. These studies have guided the design of targeted anticancer strategies. Still, the promise for pro-apoptotic inducers as lead compounds for drug development has yet to come to fruition. It was then a question of time to identify alternative modulators of c... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5378371 Thu, 13 Oct 2011 04:00:00 +0100 5378371 http://www.medworm.com/index.php?rid=5378375&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21985183%26dopt%3DAbstract Authors: Ben Ahmed M, Zaraa I, Rekik R, Elbeldi-Ferchiou A, Kourda N, Belhadj Hmida N, Abdeladhim M, Karoui O, Ben Osman A, Mokni M, Louzir H Abstract Auto-reactive cytotoxic T lymphocytes play a key role in the progressive loss or destruction of melanocytes in vitiligo but the mechanism underlying the loss of self-tolerance is unknown. A deregulation of regulatory T-cell biology has recently been suggested. The analysis of the suppressive effects of peripheral T regulatory cells in vitiligo patients revealed a functional defect in seven of 15 cases. This defect was strongly correlated with disease activity. The evaluation of the percentage of peripheral regulatory T lymphocytes did not reveal any intrinsic quantitative defect. Yet, a decrease in the percentage of such cells was no... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5378375 Tue, 11 Oct 2011 04:00:00 +0100 5378375 http://www.medworm.com/index.php?rid=5378377&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21982055%26dopt%3DAbstract In this study, we developed an in vivo vitiligo induction model to explore the underlying mechanisms leading to Koebner's phenomenon and to evaluate the efficacy of therapeutic strategies. The model consisted of 12 pigmented test regions on the back of generalized vitiligo patients that were exposed to three Koebner induction methods: cryotherapy, 755 nm laser therapy, and epidermal abrasion. In addition, four cream treatments (pimecrolimus, tacrolimus, steroid and placebo) were randomly applied. Koebnerization was efficiently induced by all three induction methods. In general, cryotherapy was the best method of Koebner induction, followed by 755 nm laser therapy and epidermal abrasion. Reproducible results were obtained, which showed enhanced depigmented surface areas and higher amoun... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5378377 Mon, 10 Oct 2011 04:00:00 +0100 5378377 http://www.medworm.com/index.php?rid=5378373&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21985222%26dopt%3DAbstract Authors: Walker GJ, Soyer HP, Terzian T, Box NF Abstract Phenotypic and molecular heterogeneity in human melanoma has impaired efforts to explain many of the clinically important features of melanoma. For example, many of the underlying mechanisms that might predict age-of-onset, time to metastasis and other key elements in melanoma progression remain unknown. Furthermore, melanoma staging used to predict outcome and treatment has not yet moved beyond a basic phenotypic classification. While molecularly targeted therapies show great promise for melanoma patients, establishing accurate animal models that recapitulate human cutaneous melanoma progression remains a priority. We examine the relevance of mice as models for human melanoma progression and for key molecular and histopathol... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5378373 Mon, 10 Oct 2011 04:00:00 +0100 5378373 http://www.medworm.com/index.php?rid=5378381&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21981974%26dopt%3DAbstract Authors: Mullarky E, Mattaini KR, Vander Heiden MG, Cantley LC, Locasale JW Abstract The metabolic requirements of cancer cells differ from that of their normal counterparts. To support their proliferation, cancer cells switch to a fermentative metabolism that is thought to support biomass production. Instances where metabolic enzymes promote tumorigenesis remain rare. However, an enzyme involved in the de novo synthesis of serine, 3-phosphoglycerate dehydrogenase (PHGDH), was recently identified as a putative oncogene. The potential mechanisms by which PHGDH promotes cancer are discussed. PMID: 21981974 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5378381 Sat, 08 Oct 2011 04:00:00 +0100 5378381 http://www.medworm.com/index.php?rid=5378379&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21981993%26dopt%3DAbstract Authors: Craig EA, Spiegelman VS Abstract We previously reported that malignant melanomas express high levels of the mRNA binding protein coding region determinant binding protein (CRD-BP). This molecule is important for the activation of anti-apoptotic pathways, a mechanism often linked to insensitivity to therapeutics. However, it is not known whether CRD-BP plays a role in the resistance of melanomas to anti-cancer treatment. Here we demonstrate that knockdown of CRD-BP with a specific sh-RNA enhances the effect of dacarbazine, temozolomide, vinblastine, and etoposide on both primary and metastatic melanoma cell lines. CRD-BP down-regulation contributes to cell sensitization by increasing apoptosis and diminishing melanoma cell growth in response to chemotherapeutic agents. Furt... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5378379 Sat, 08 Oct 2011 04:00:00 +0100 5378379 http://www.medworm.com/index.php?rid=5294857&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21978301%26dopt%3DAbstract Authors: Mosenson JA, Zloza A, Klarquist J, Barfuss AJ, Guevara-Patino JA, Le Poole IC Abstract HSP70i and other stress proteins have been used in anti-tumor vaccines. This begs the question whether HSP70i plays a unique role in immune activation. We vaccinated inducible HSP70i (Hsp70-1) knockout mice and wild-type animals with optimized TRP-1, a highly immunogenic melanosomal target molecule. We were unable to induce robust and lasting depigmentation in the Hsp70-1 knockout mice, and in vivo cytolytic assays revealed a lack of CTL activity. Absence of T cell infiltration to the skin and maintenance of hair follicle melanocytes was observed. By contrast, depigmentation proceeded without interruption in mice lacking a tissue specific constitutive isoform of HSP70 (Hsp70-2) vaccinate... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5294857 Thu, 06 Oct 2011 04:00:00 +0100 5294857 http://www.medworm.com/index.php?rid=5294855&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21978367%26dopt%3DAbstract Authors: O'Connell MP, Weeraratna AT Abstract Heparan sulfate proteoglycans have been shown to regulate signaling in many systems and are of increasing interest in cancer. While not the only sugars to drive melanoma metastasis, HSPGs play important roles in driving metastatic signaling cascades in melanoma. The ability of these proteins to modulate ligand-receptor interactions in melanoma has been quite understudied. Recent data from several groups indicates the importance of these ligands in modulating key signaling pathways including Wnt and FGF signaling. In this review, we summarize the current knowledge regarding the structure and function of these proteoglycans, and their role in melanoma. Understanding how heparan sulfate proteoglycans modulate signaling in melanoma could le... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5294855 Thu, 06 Oct 2011 04:00:00 +0100 5294855 http://www.medworm.com/index.php?rid=5294859&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21974864%26dopt%3DAbstract Authors: Krochmann J, Sinnberg T, Meier F, Garbe C, Busch C PMID: 21974864 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5294859 Tue, 04 Oct 2011 04:00:00 +0100 5294859 http://www.medworm.com/index.php?rid=5419842&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22081810%26dopt%3DAbstract Authors: Wajapeyee N, Green MR PMID: 22081810 [PubMed - in process] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5419842 Sat, 01 Oct 2011 04:00:00 +0100 5419842 http://www.medworm.com/index.php?rid=5419841&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22081811%26dopt%3DAbstract Authors: Dann SG, Abraham RT PMID: 22081811 [PubMed - in process] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5419841 Sat, 01 Oct 2011 04:00:00 +0100 5419841 http://www.medworm.com/index.php?rid=5419840&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22081812%26dopt%3DAbstract Authors: Fuchs SY PMID: 22081812 [PubMed - in process] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5419840 Sat, 01 Oct 2011 04:00:00 +0100 5419840 http://www.medworm.com/index.php?rid=5378387&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21981930%26dopt%3DAbstract Authors: Ronai Z PMID: 21981930 [PubMed - in process] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5378387 Sat, 01 Oct 2011 04:00:00 +0100 5378387 http://www.medworm.com/index.php?rid=5378385&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21981931%26dopt%3DAbstract Authors: Zuckerman JE, Ribas A, Davis ME PMID: 21981931 [PubMed - in process] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5378385 Sat, 01 Oct 2011 04:00:00 +0100 5378385 http://www.medworm.com/index.php?rid=5378383&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21981932%26dopt%3DAbstract Authors: PMID: 21981932 [PubMed - in process] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5378383 Sat, 01 Oct 2011 04:00:00 +0100 5378383 http://www.medworm.com/index.php?rid=5271177&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21955491%26dopt%3DAbstract Authors: Gallagher SJ, Luciani F, Berlin I, Rambow F, Gros G, Champeval D, Delmas V, Larue L PMID: 21955491 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5271177 Thu, 29 Sep 2011 04:00:00 +0100 5271177 http://www.medworm.com/index.php?rid=5271178&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21951761%26dopt%3DAbstract Authors: Sturm R PMID: 21951761 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5271178 Mon, 26 Sep 2011 04:00:00 +0100 5271178 http://www.medworm.com/index.php?rid=5271179&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21943097%26dopt%3DAbstract In conclusion, our results suggest that MART-1 is a pigmentation gene which is required for melanosome biogenesis and/or maintenance. PMID: 21943097 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5271179 Wed, 21 Sep 2011 04:00:00 +0100 5271179 http://www.medworm.com/index.php?rid=5235518&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21914141%26dopt%3DAbstract Authors: Lopez-Bergami P Abstract Recent discoveries have increased our comprehension of the molecular signaling events critical for melanoma development and progression. Many oncogenes driving melanoma have been identified and most of them exert their oncogenic effects through the activation of the RAF/MEK/ERK mitogen-activated protein kinase (MAPK) pathway. The JNK and p38 MAPK pathways are also important in melanoma but their precise role is not clear yet. This review summarizes our current knowledge on the role of the three main MAPK pathways - ERK, JNK and p38 - and their impact on melanoma biology. Although the results obtained with BRAF inhibitors in melanoma patients are impressive, several mechanisms of acquired resistance have emerged. To overcome this obstacle constitute... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5235518 Tue, 13 Sep 2011 04:00:00 +0100 5235518 http://www.medworm.com/index.php?rid=5235519&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21910852%26dopt%3DAbstract Authors: Larue L, Davidson I PMID: 21910852 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5235519 Mon, 12 Sep 2011 04:00:00 +0100 5235519 http://www.medworm.com/index.php?rid=5205540&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21899726%26dopt%3DAbstract Authors: Herlyn M, Villanueva J PMID: 21899726 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5205540 Thu, 08 Sep 2011 04:00:00 +0100 5205540 http://www.medworm.com/index.php?rid=5191973&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21883983%26dopt%3DAbstract Authors: Sundström E, Komisarczuk AZ, Jiang L, Golovko A, Navratilova P, Rinkwitz S, Becker TS, Andersson L Abstract Greying with age in horses is an autosomal dominant trait, characterized by hair greying, high incidence of melanoma and vitiligo-like depigmentation. Previous studies have revealed that the causative mutation for this phenotype is a 4.6 kb intronic duplication in STX17 (Syntaxin 17). By using reporter constructs in transgenic zebrafish, we show that a construct containing two copies of the duplicated sequence acts as a strong enhancer in neural crest cells and has subsequent melanophore-specific activity during zebrafish embryonic development whereas a single copy of the duplicated sequence acts as a weak enhancer, consistent with the phenotypic manifestation of th... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5191973 Mon, 29 Aug 2011 23:00:00 +0100 5191973 http://www.medworm.com/index.php?rid=5191974&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21883982%26dopt%3DAbstract We report the first cellular studies on GSIII melanocytes, which demonstrated that MLPH(R35W) causes perinuclear aggregation of melanosomes in melanocytes, typical for GS. Additionally, co-immunoprecipitation assays showed that MLPH(R35W) lost its interaction with RAB27A, indicating pathogenicity of the R35W mutation. PMID: 21883982 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5191974 Wed, 24 Aug 2011 23:00:00 +0100 5191974 http://www.medworm.com/index.php?rid=5158331&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21848663%26dopt%3DAbstract Authors: Tock CL, Turner LR, Altiner A, Batra P, Booher SL, Coelho SG, Warner JA, Therrien JP, Turner ML, Miller SA, Beer JZ, Kraemer KH, Udey MC, Vogel JC, Terunuma A PMID: 21848663 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5158331 Tue, 16 Aug 2011 23:00:00 +0100 5158331 http://www.medworm.com/index.php?rid=5138435&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21843162%26dopt%3DAbstract Authors: Kirkwood JM PMID: 21843162 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5138435 Mon, 15 Aug 2011 23:00:00 +0100 5138435 http://www.medworm.com/index.php?rid=5125608&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21834848%26dopt%3DAbstract Authors: Slominski A, Zmijewski M, Pawelek J Evidence reveals that L-tyrosine and L-DOPA, besides serving as substrates and intermediates of melanogenesis, are also bioregulatory agents acting not only as inducers and positive regulators of melanogenesis but also as regulators of other cellular functions. These can be mediated through action on specific receptors or through non-receptor mediated mechanisms. The substrate induced (L-tyrosine and/or L-DOPA) melanogenic pathway would autoregulate itself as well as it would regulate the melanocyte functions through activity of its structural or regulatory proteins and through intermediates of melanogenesis and melanin itself. Dissection of regulatory and autoregulatory elements of this process may elucidate how substrate induced autoregula... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5125608 Wed, 10 Aug 2011 23:00:00 +0100 5125608 http://www.medworm.com/index.php?rid=5118344&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21827641%26dopt%3DAbstract Authors: Greco G, Panzella L, Napolitano A, d'Ischia M PMID: 21827641 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5118344 Mon, 08 Aug 2011 23:00:00 +0100 5118344 http://www.medworm.com/index.php?rid=5158330&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21851583%26dopt%3DAbstract Authors: Arnheiter H PMID: 21851583 [PubMed - in process] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5158330 Sun, 31 Jul 2011 23:00:00 +0100 5158330 http://www.medworm.com/index.php?rid=5158329&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21851584%26dopt%3DAbstract Authors: PMID: 21851584 [PubMed - in process] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5158329 Sun, 31 Jul 2011 23:00:00 +0100 5158329 http://www.medworm.com/index.php?rid=5095602&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21801332%26dopt%3DAbstract In this report, we provide evidence that GLI2 and M-MITF have an exclusive expression pattern in melanoma cells and demonstrate that GLI2 and M-MITF antagonize each other and control melanoma cell invasion in an opposite manner. PMID: 21801332 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5095602 Sun, 31 Jul 2011 23:00:00 +0100 5095602 http://www.medworm.com/index.php?rid=5077415&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21794098%26dopt%3DAbstract Authors: Dwivedi M, Laddha NC, Imran M, Shah BJ, Begum R PMID: 21794098 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5077415 Tue, 26 Jul 2011 23:00:00 +0100 5077415 http://www.medworm.com/index.php?rid=5069226&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21781286%26dopt%3DAbstract Authors: Kirkwood JM PMID: 21781286 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5069226 Fri, 22 Jul 2011 23:00:00 +0100 5069226 http://www.medworm.com/index.php?rid=5069225&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21787378%26dopt%3DAbstract Authors: Kim MO, Kim SH, Oi N, Lee MH, Yu DH, Kim DJ, Cho EJ, Bode AM, Cho YY, Bowden TG, Dong Z The cancer microenvironment affects cancer cell proliferation and growth. Embryonic stem (ES)-preconditioned 3-dimensional (3-D) culture of cancer cells induces cancer cell reprogramming and results in a change in cancer cell properties such as differentiation and migration in skin melanoma. However, the mechanism has not yet been clarified. Using the ES-preconditioned 3-D microenvironment model, we provide evidence showing that the ES microenvironment inhibits proliferation and anchorage-independent growth of SK-MEL-28 melanoma cells. We also found that the ES microenvironment suppresses telomerase activity and thereby induces senescence in SK-MEL-28 cells. Furthermore, we observed that gr... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5069225 Fri, 22 Jul 2011 23:00:00 +0100 5069225 http://www.medworm.com/index.php?rid=5069227&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21777401%26dopt%3DAbstract Authors: Ho H, Ganesan AK Melanin pigments protect the skin and eyes from toxic insults and are critical for the normal functioning of multiple organ systems including the skin, eyes, and brain. Biochemical and genetic studies in both human and mice have revealed the molecular machinery that controls the transcription of genes encoding enzymes that produce melanin and the trafficking of these enzymes to the melanosome, a lysosome-related organelle dedicated to melanin synthesis. Recent functional genomic studies have identified a role for genes previously known to regulate autophagy, a cellular process that facilitates nutrient recycling during starvation, in the biogenesis of melanosomes in vitro and in vivo. In this review, we describe the pleiotropic roles of autophagy regulators in... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5069227 Wed, 20 Jul 2011 23:00:00 +0100 5069227 http://www.medworm.com/index.php?rid=5050105&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21762468%26dopt%3DAbstract Authors: Flori E, Mastrofrancesco A, Kovacs D, Ramot Y, Briganti S, Bellei B, Paus R, Picardo M Given the importance of the tanning response in protecting human skin from the harmful effects of UV radiation, one important research priority is to identify novel molecules that are capable of promoting pigmentation and/or antioxidant defence. Parrodienes share some structural features with carotenoids and retinoids, stimulate cell antioxidant defence and counteract senescence-like phenotype in fibroblasts. Thefore, we selected the parrodiene-derivative, 2,4,6-octatrienoic acid (Octa), to study its impact on key parameters of melanogenesis and antioxidant defence in organ-cultured human skin and in normal human melanocytes (NHMs). We demonstrated that Octa promoted melanogenesis by up-regu... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5050105 Sun, 17 Jul 2011 23:00:00 +0100 5050105 http://www.medworm.com/index.php?rid=5050103&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21762469%26dopt%3DAbstract Pitfalling in nanomedical targeting of melanoma: A "clinical" case of misdelivered RNAi. Pigment Cell Melanoma Res. 2011 Jul 18; Authors: Perris R, Borghese C, Magro G PMID: 21762469 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5050103 Sun, 17 Jul 2011 23:00:00 +0100 5050103 http://www.medworm.com/index.php?rid=5007770&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21733131%26dopt%3DAbstract Authors: Low D, Chen KS Angelman syndrome (AS) is a neurogenetic disorder caused by the lack of functional ubiquitin-protein ligase E3A (UBE3A) that acts as an E3 ligase in the ubiquitin-proteosomal degradation pathway and/or as a transcriptional coactivator. Besides neurological deficit, hypopigmentation is another phenotype associated with AS patients currently attributed towards the hemizygosity of the type II oculocutaneous albinism (OCA2) gene. Here we show that the melanocortin-1-receptor (MC1R) is down-regulated in the skin of the Ube3a((-/-)) mice. Luciferase-reporter assay shows that UBE3A is able to induce MC1R promoter activity. Using chromatin immunoprecipitation assay, Ube3a was observed to be physically associated with the Mc1r promoter. Deletion of the E box/SP1 element ... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5007770 Tue, 05 Jul 2011 23:00:00 +0100 5007770 http://www.medworm.com/index.php?rid=5007771&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21722328%26dopt%3DAbstract Authors: Song L, Ritchie AM, McNeil EM, Li W, Melton DW Increased expression of DNA repair genes contributes to the extreme resistance shown by melanoma to conventional DNA-damaging chemotherapeutics. One such chemotherapeutic effective against a range of other cancers, but not melanoma, is cisplatin. The DNA repair protein, ERCC1, is needed to remove cisplatin-induced DNA damage. We have shown that ERCC1 is essential for melanoma growth and resistance to cisplatin in a mouse xenograft model. Untreated xenografts of our transformed Ercc1-proficient melanocyte cell line grew very rapidly as malignant melanoma. Cisplatin treatment caused initial shrinkage of xenografts, but cisplatin-resistant regrowth soon followed. Cells reisolated into culture had two-fold elevated levels of ERCC1 com... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5007771 Fri, 01 Jul 2011 23:00:00 +0100 5007771 http://www.medworm.com/index.php?rid=4984220&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21711453%26dopt%3DAbstract Authors: Mattia G, Errico MC, Felicetti F, Petrini M, Bottero L, Tomasello L, Romania P, Boe A, Segnalini P, Di Virgilio A, Colombo MP, Carè A MicroRNAs-221 and -222 are highly up-regulated in several solid tumors, including melanomas. We demonstrate that the proto-oncogene ETS-1, involved in the pathogenesis of cancers of different origin, is a transcriptional regulator of miR-222 by direct binding to its promoter region. Differently from 293FT cells or early stage melanomas, where not phosphorylated ETS-1 represses miR-222 transcription, in metastatic melanoma the constitutively Thr-38 phosphorylated fraction of ETS-1 induces miR-222. Despite its stepwise decreased expression along with melanoma progression, the oncogenic activity of ETS-1 relies on its RAS/RAF/ERK-dependent phospho... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4984220 Mon, 27 Jun 2011 23:00:00 +0100 4984220 http://www.medworm.com/index.php?rid=4984221&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21707960%26dopt%3DAbstract Authors: Whiteman DC, Pavan WJ, Bastian BC Converging lines of evidence from varied scientific disciplines suggest that cutaneous melanomas comprise biologically distinct subtypes that arise through multiple causal pathways. Understanding the respective relationships of each subtype with etiologic factors such as UV-radiation and constitutional factors is the first necessary step towards developing refined prevention strategies for the specific forms of melanoma. Furthermore, classifying this disease precisely into biologically distinct subtypes is the key to developing mechanism-based treatments, as highlighted by recent discoveries. In this review, we outline the historical developments that underpin our understanding of melanoma heterogeneity, and we do this from the perspectives of... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4984221 Sun, 26 Jun 2011 23:00:00 +0100 4984221 http://www.medworm.com/index.php?rid=4984222&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21696572%26dopt%3DAbstract Authors: Quaglino P, Osella-Abate S, Marenco F, Nardò T, Gado C, Novelli M, Savoia P, Bernengo M PMID: 21696572 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4984222 Tue, 21 Jun 2011 23:00:00 +0100 4984222 http://www.medworm.com/index.php?rid=4959844&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21689385%26dopt%3DAbstract Authors: van den Boorn JG, Melief CJ, Luiten RM Autoimmune side-effects such as vitiligo regularly occur during melanoma immunotherapy. Vitiligo development being associated with a superior prognosis, the active induction of vitiligo in melanoma patients can be a useful tactic. The potent skin-depigmenting agent monobenzone can be successfully used for this purpose. Until recently however, the mechanism of action behind monobenzone-induced skin depigmentation was unclear. Lately, the mechanistic basis for the augmented immunogenicity of monobenzone-exposed pigmented cells has been unveiled, and their active role in the induction of autoimmune T-cell-mediated vitiligo has become apparent. Here, we provide an immunological framework in which we condense this knowledge to an integrated th... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4959844 Sun, 19 Jun 2011 23:00:00 +0100 4959844 http://www.medworm.com/index.php?rid=4933606&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21672181%26dopt%3DAbstract Authors: Krengel S, Breuninger H, Beckwith M, Etchevers HC An unconventional symposium on the subject of pathogenetic, clinical, and therapeutic aspects of large and giant congenital melanocytic nevi and neurocutaneous melanocytosis, was held at the University of Tübingen, Germany, on May 6-7, 2011. Exchanges were made between physicians from a wide range of clinical disciplines, including pathology, dermatology, plastic and pediatric surgery, neurosurgery, pediatric neurology and genetics; basic scientists in cell and developmental biology; psychologists; and an unprecedented gathering of international patient advocacy group representatives. This diversity of outlooks brought fresh perspectives to the discussions about current scientific and therapeutic advances in the field of these... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4933606 Tue, 14 Jun 2011 23:00:00 +0100 4933606 http://www.medworm.com/index.php?rid=4933605&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21672182%26dopt%3DAbstract Authors: Menin C, Vecchiato A, Scaini MC, Elefanti L, Funari G, De Salvo GL, Quaggio M, Tognazzo S, Agata S, Santa SD, Montagna M, Alaibac M, Chiarion-Sileni V, D'Andrea E PMID: 21672182 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4933605 Tue, 14 Jun 2011 23:00:00 +0100 4933605 http://www.medworm.com/index.php?rid=4876299&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21615880%26dopt%3DAbstract Authors: Guarneri F, Asmundo A, Sapienza D, Cannavò SP PMID: 21615880 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4876299 Wed, 25 May 2011 23:00:00 +0100 4876299 http://www.medworm.com/index.php?rid=4876298&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21615881%26dopt%3DAbstract Authors: Devitt B, Liu W, Salemi R, Wolfe R, Kelly J, Tzen CY, Dobrovic A, McArthur G The effect of NRAS mutations on the pathological features and clinical outcomes in patients with cutaneous melanoma was compared to tumors containing BRAF(V600E) mutations and tumors wild-type for both (WT). Clinical outcome data was obtained from a prospective cohort of 249 patients. Mutations involving NRAS and BRAF(V600E) were detected by PCR and were sequence verified. Cox proportional hazards regression was performed to relate NRAS and BRAF mutations to clinical outcome. 75% of NRAS mutations occurred in tumors >1mm thick (BRAF(V600E) 40%, WT 34%). 75% of NRAS mutations had >1 mitosis/mm(2) (BRAF(V600E) 40%, WT 55%). When compared to WT, multivariate analysis of melanoma specific survival (... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4876298 Wed, 25 May 2011 23:00:00 +0100 4876298 http://www.medworm.com/index.php?rid=4841106&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21575141%26dopt%3DAbstract Authors: Goding C PMID: 21575141 [PubMed - in process] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4841106 Thu, 19 May 2011 23:45:22 +0100 4841106 http://www.medworm.com/index.php?rid=4841104&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21575142%26dopt%3DAbstract Authors: Landreville S, Agapova OA, Kneass ZT, Salesse C, William Harbour J Metastasis of tumor cells to distant organs is the leading cause of death in melanoma. Yet, the mechanisms of metastasis remain poorly understood. One key question is whether all cells in a primary tumor are equally likely to metastasize or whether subpopulations of cells preferentially give rise to metastases. Here, we identified a subpopulation of uveal melanoma cells expressing the multidrug resistance transporter ABCB1 that are highly metastatic compared to ABCB1(-) bulk tumor cells. ABCB1(+) cells also exhibited enhanced clonogenicity, anchorage-independent growth, tumorigenicity and mitochondrial activity compared to ABCB1(-) cells. A375 cutaneous melanoma cells contained a similar subpopulation of highly... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4841104 Thu, 19 May 2011 23:45:14 +0100 4841104 http://www.medworm.com/index.php?rid=4862234&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21599871%26dopt%3DAbstract Authors: Eichhoff OM, Weeraratna A, Zipser MC, Denat L, Widmer DS, Xu M, Kriegl L, Kirchner T, Larue L, Dummer R, Hoek KS Recent observations suggest that melanoma cells drive disease progression by switching back-and-forth between phenotypic states of proliferation and invasion. Phenotype switching has been linked to changes in Wnt signalling and we therefore looked for cell phenotype-specific differences in the levels and activity of β-catenin and its LEF/TCF co-factors. We found that while cytosolic β-catenin distribution is phenotype-specific (membrane-associated in proliferative cells and cytosolic in invasive cells), its nuclear distribution and activity is not. Instead, the expression patterns of two β-catenin co-factors, LEF1 and TCF4, are both phenotype-specific and inverse... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4862234 Thu, 19 May 2011 23:00:00 +0100 4862234 http://www.medworm.com/index.php?rid=4852687&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21595858%26dopt%3DAbstract Authors: Liang R, Wallace AR, Schadendorf D, Rubin BP Mouse Kit L575P, the orthologue of human KIT L576P, a common KIT mutation found in human melanoma, was expressed in an immortalized but non-transformed mouse Ink4a-Arf-deficient melanocyte cell line. The resultant Ink4a-Arf deficient Kit L575P expressing melanocytes exhibited increased proliferation, the ability to grow in soft agar, and increased migration. When these cells were injected subcutaneously into NOD/SCID/gamma(c) mice, melanomas arose in 5 of 7 (71%) mice. 1 of 7 mice (14%) injected with these cells developed metastatic disease. Evaluation of signal transduction pathways downstream of constitutively activated Kit L575P revealed striking activation of the phosphatidyl inositol 3-kinase (PI3K) pathway. Inhibition of the P... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4852687 Wed, 18 May 2011 23:00:00 +0100 4852687 http://www.medworm.com/index.php?rid=4847754&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21592316%26dopt%3DAbstract Authors: Feng Y, Barile E, De SK, Stebbins JL, Cortez A, Aza-Blanc P, Villanueva J, Heryln M, Krajewski S, Pellecchia M, Ronai ZA, Chiang GG In melanoma, the activation of pro-survival signaling pathways, such as the AKT and NF-κB pathways, are critical for tumor growth. We have recently reported that the AKT inhibitor BI-69A11 causes efficient inhibition of melanoma growth. Here, we show that in addition to its AKT inhibitory activity, BI-69A11 also targets the NF-κB pathway. In melanoma cell lines, BI-69A11 inhibited TNF-α-stimulated IKKα/β and IκB phosphorylation as well as NF-κB reporter gene expression. Furthermore, the effective inhibition of melanoma growth by BI-69A11 was attenuated upon NF-κB activation. Mechanistically, reduced NF-κB signaling by BI-69-A11 is mediate... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4847754 Wed, 18 May 2011 23:00:00 +0100 4847754 http://www.medworm.com/index.php?rid=4847753&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21592317%26dopt%3DAbstract Authors: Meltzer P PMID: 21592317 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4847753 Wed, 18 May 2011 23:00:00 +0100 4847753 http://www.medworm.com/index.php?rid=4847752&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21592318%26dopt%3DAbstract Authors: Landreville S, Vigneault F, Bergeron MA, Leclerc S, Gaudreault M, Morcos M, Mouriaux F, Salesse C, Guérin SL Cancer aggressiveness is related to the ability of cancer cells to escape the anchorage dependency toward the extracellular matrix, a process regulated by the integrin α5β1 and its ligand fibronectin. Here, we characterized the expression of the α5 gene in human uveal melanoma cell lines with distinct tumorigenic properties and investigated some of the mechanisms underlying the variations of their malignancy. Strong and weak expression of α5 was observed in cells with no (T108/T115) and high (T97/T98) tumorigenic properties, respectively. Expression and DNA binding of the transcription factors Sp1, AP-1 (both acting as activators) and NFI (a strong repressor) to th... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4847752 Wed, 18 May 2011 23:00:00 +0100 4847752 http://www.medworm.com/index.php?rid=4788902&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21535480%26dopt%3DAbstract Authors: Fisher DE PMID: 21535480 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4788902 Mon, 02 May 2011 23:00:00 +0100 4788902 http://www.medworm.com/index.php?rid=4788903&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21535429%26dopt%3DAbstract Authors: Ito S, Nakanishi Y, Valenzuela RK, Brilliant MH, Kolbe L, Wakamatsu K Eumelanin and pheomelanin in tissue samples can be specifically measured as the markers pyrrole-2,3,5-tricarboxylic acid (PTCA) and 4-amino-3-hydroxyphenylalanine after acidic permanganate oxidation and hydroiodic acid hydrolysis, respectively. Those degradation methods, although widely applied, are not easily performed in most laboratories. To overcome this difficulty, we developed alkaline H(2) O(2) oxidation in 1M K(2) CO(3) that produces, in addition to the eumelanin marker PTCA, thiazole-2,4,5-tricarboxylic acid (TTCA) and thiazole-4,5-dicarboxylic acid (TDCA) as markers for pheomelanin and pyrrole-2,3-dicarboxylic acid (PDCA) as a marker for 5,6-dihydroxyindole-derived eumelanin. Those 4 degradation pr... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4788903 Tue, 26 Apr 2011 23:00:00 +0100 4788903 http://www.medworm.com/index.php?rid=4788901&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21539721%26dopt%3DAbstract Authors: Baljinnyam E, Umemura M, De Lorenzo MS, Iwatsubo M, Chen S, Goydos JS, Iwatsubo K Our previous report suggested the potential role of the exchange protein directly activated by cyclic AMP (Epac) in melanoma metastasis via heparan sulfate (HS)-mediated cell migration. In order to obtain conclusive evidence that Epac1 plays a critical role in modification of HS and melanoma metastasis, we extensively investigated expression and function of Epac1 in human melanoma samples and cell lines. We have found that, in human melanoma tissue microarray, protein expression of Epac1 was higher in metastatic melanoma than in primary melanoma. In addition, expression of Epac1 positively correlated with that of N-sulfated HS, and N-deacetylase/N-sulfotransferase-1 (NDST-1), an enzyme which incr... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4788901 Mon, 18 Apr 2011 23:00:00 +0100 4788901 http://www.medworm.com/index.php?rid=4753505&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21501420%26dopt%3DAbstract Authors: Beuret L, Ohanna M, Strub T, Allegra M, Davidson I, Bertolotto C, Ballotti R PMID: 21501420 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4753505 Mon, 18 Apr 2011 23:00:00 +0100 4753505 http://www.medworm.com/index.php?rid=4753507&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21501418%26dopt%3DAbstract In this study we investigated effects of ultraviolet radiation (UVR) on the expression of human endogenous retrovirus type K (HERV-K) in melanoma cells and non-melanoma cells in vitro. Solely in melanoma cell lines, irradiation with UVB (200 mJ cm(-2) ) resulted in a significant transcriptional activation of the retroviral pol gene as well as in an enhanced expression of the retroviral envelope protein (env). In addition, UVB treatment induced the production of retroviral particles in the supernatants of melanoma cell lines. This data indicates that HERV-K expression can be activated by UVB irradiation and suggests an involvement of HERV-K in UVR-related melanoma pathogenesis. PMID: 21501418 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4753507 Sun, 17 Apr 2011 23:00:00 +0100 4753507 http://www.medworm.com/index.php?rid=4753506&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21501419%26dopt%3DAbstract Authors: Goda M, Ohata M, Ikoma H, Fujiyoshi Y, Sugimoto M, Fujii R In the reddish-violet parts of the skin of the diadema pseudochromis Pseudochromis diadema, we found novel dichromatic chromatophores with a reddish pigment and reflecting platelets. We named these novel cells "erythro-iridophores". In standard physiological solution, erythro-iridophores displayed two hues, red and dark violet when viewed with an optical microscope under ordinary transmission light and epi-illumination optics, respectively. Under transmission electron microscopy, however, we observed no typical red chromatosomes, i.e., erythrosomes, in the cytoplasm. High-performance thin layer chromatography (HPTLC) analysis of the pigment eluted from the erythro-iridophores, indicated that carotenoid is the main pigm... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4753506 Sun, 17 Apr 2011 23:00:00 +0100 4753506 http://www.medworm.com/index.php?rid=4704394&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21477078%26dopt%3DAbstract In this study, we investigated a mechanism of resistance involving a regulatory domain, called linker region, in Smad2 and Smad3, main downstream effectors of TGFβ. Melanoma cells in culture and in tumor samples exhibited constitutive Smad2 and Smad3 linker phosphorylation. Treatment of melanoma cells with the MEK1/2 inhibitor, U0126, or the two pan-CDK and GSK3 inhibitors, Flavopiridol and R547, resulted in decreased linker phosphorylation of Smad2 and Smad3. Overexpression of the linker phosphorylation-resistant Smad3 EPSM mutant in melanoma cells resulted in an increase in expression of p15(INK4B) and p21(WAF1) , as compared with cells transfected with wild-type Smad3. In addition, the cell numbers of EPSM Smad3-expressing melanoma cells were significantly reduced compared to wild-type... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4704394 Wed, 06 Apr 2011 23:00:00 +0100 4704394 http://www.medworm.com/index.php?rid=4684004&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21466663%26dopt%3DAbstract Authors: Ghislin S, Obino D, Middendorp S, Boggetto N, Alcaide-Loridan C, Deshayes F One of the main steps of metastasis is extravasation, a phenomenon well described in lymphocytes, but remaining to be fully uncovered for melanoma. Junctional Adhesion Molecules (JAMs) are controlling the transendothelial migration of leukocytes. To date the role of the JAM proteins, notably JAM-A and JAM-C, has not been examined in melanoma. Here, we compared two melanoma tumor cell lines, A375 and SLM8 cells, the A375 cell line being four times more efficient than the SLM8 cells in the crossing of the endothelial monolayer. We evidence the differential expression of JAM-A and JAM-C in these cell lines with JAM-C mainly expressed in the A375 cell line, and JAM-A detected preferentially in the SLM8 cel... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4684004 Tue, 05 Apr 2011 23:00:00 +0100 4684004 http://www.medworm.com/index.php?rid=4684003&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21466664%26dopt%3DAbstract Authors: Levati L, Pagani E, Romani S, Castiglia D, Piccinni E, Covaciu C, Caporaso P, Bondanza S, Antonetti FR, Bonmassar E, Martelli F, Alvino E, D'Atri S The SKI protein is a transcriptional co-regulator over-expressed in melanoma. Experimentally induced down-regulation of SKI inhibits melanoma cell growth in vitro and in vivo. Micro-RNAs (miRNAs) negatively modulate gene expression, and have been implicated in oncogenesis. We previously showed that microRNA-155 (miR-155) is down-regulated in melanoma cells as compared with normal melanocytes, and that its ectopic expression impairs proliferation and induces apoptosis. Here, we investigated whether miR-155 could mediate melanoma growth inhibition via SKI gene silencing. Luciferase reporter assays demonstrated that miR-155 interacted... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4684003 Tue, 05 Apr 2011 23:00:00 +0100 4684003 http://www.medworm.com/index.php?rid=4684006&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21466661%26dopt%3DAbstract Authors: Nishimura EK Most mammals are coated with pigmented hair. Melanocytes in each hair follicle produce melanin pigments for the hair during each hair cycle. The key to understanding the mechanism of cyclic melanin production is the melanocyte stem cell (MelSC) population, previously known as "amelanotic melanocytes". The MelSC population resides in the hair follicle bulge-subbulge area, the lower-most permanent portion of the hair follicle, which serves as a melanocyte reservoir for skin and hair pigmentation. MelSCs form a stem cell system within individual hair follicles and provide a "hair pigmentary unit" for each cycle of hair pigmentation. This review focuses on the identification of MelSCs and their characteristics and explains the importance of the MelSC population in the... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4684006 Mon, 04 Apr 2011 23:00:00 +0100 4684006 http://www.medworm.com/index.php?rid=4684005&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21466662%26dopt%3DAbstract Authors: Barnhill RL, Busam KJ, From L, Bagot M, Lugassy C, Berwick M PMID: 21466662 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4684005 Mon, 04 Apr 2011 23:00:00 +0100 4684005 http://www.medworm.com/index.php?rid=4684007&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21457482%26dopt%3DAbstract Authors: Leupold D, Scholz M, Stankovic G, Reda J, Buder S, Eichhorn R, Wessler G, Stücker M, Hoffmann K, Bauer J, Garbe C Malignant transformation of melanocytes is associated with changes in melanogenesis. Therefore, fluorescence of melanin may be an informative indicator of this process. But the conventionally excited autofluorescence of melanin in skin tissue is ultra-weak and its main part in the visible spectral region is hidden by the much stronger fluorescence from other endogeneous fluorophores. Here, using a new mode of stepwise two-photon excitation, melanin-dominated fluorescence spectra of pigmented skin lesions are reported. From these, pure melanin fluorescence spectra of normal pigmented skin, of melanocytic nevi as well as of malignant pigmented melanoma were analyzed... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4684007 Fri, 01 Apr 2011 23:00:00 +0100 4684007 http://www.medworm.com/index.php?rid=4753504&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21513006%26dopt%3DAbstract Authors: Hoek KS PMID: 21513006 [PubMed - in process] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4753504 Thu, 31 Mar 2011 23:00:00 +0100 4753504 http://www.medworm.com/index.php?rid=4753503&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21513008%26dopt%3DAbstract Authors: Poenitzsch AM, Setaluri V, Spiegelman VS PMID: 21513008 [PubMed - in process] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4753503 Thu, 31 Mar 2011 23:00:00 +0100 4753503 http://www.medworm.com/index.php?rid=4753502&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21513010%26dopt%3DAbstract Unwelcome guests: macrophages promote UV-induced melanoma. Pigment Cell Melanoma Res. 2011 Apr;24(2):265-7 Authors: Damsky WE, Bosenberg M PMID: 21513010 [PubMed - in process] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4753502 Thu, 31 Mar 2011 23:00:00 +0100 4753502 http://www.medworm.com/index.php?rid=4636267&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21426532%26dopt%3DAbstract Authors: Syed DN, Mukhtar H Cutaneous melanoma, a cancer of melanocytes, when detected at later stages is arguably one of the most lethal cancers and the cause of more years of lost life than any other cancer among young adults. There is no standard therapy for advanced-stage melanoma and the median survival time for patients with metastatic melanoma is less than one year. An urgent need for novel strategies against melanoma has directed research towards development of new chemotherapeutic and biologic agents that can target the tumor by several different mechanisms. Recently, several dietary agents are being investigated for their role in the prevention and treatment of various forms of cancer and may represent the future modality of the treatment. Here, we have reviewed emerging data... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4636267 Wed, 23 Mar 2011 00:00:00 +0100 4636267 http://www.medworm.com/index.php?rid=4626694&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21418545%26dopt%3DAbstract Authors: Soo JK, Mackenzie Ross AD, Kallenberg DM, Milagre C, Heung Chong W, Chow J, Hill L, Hoare S, Collinson RS, Hossain M, Nicol Keith W, Marais R, Bennett DC Cell senescence is a permanent growth arrest following extended proliferation. Cultured cancer cells including metastatic melanoma cells often appear immortal (proliferate indefinitely), while uncultured benign nevi (moles) show senescence markers. Here, with new explantation methods, we investigated which classes of primary pigmented lesions are typically immortal. Nevi yielded a few proliferating cells, consistent with most nevus cells being senescent. No nevus culture (0/28) appeared immortal. Some thin and thick melanoma cultures proved immortal under these conditions, but surprisingly few (4/37). All arrested cultures di... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4626694 Mon, 21 Mar 2011 00:00:00 +0100 4626694 http://www.medworm.com/index.php?rid=4653045&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21435193%26dopt%3DAbstract Authors: Boyle GM, Woods SL, Bonazzi VF, Stark MS, Hacker E, Aoude LG, Dutton-Regester K, Cook AL, Sturm RA, Hayward NK To identify microRNAs potentially involved in melanomagenesis we compared microRNA expression profiles between melanoma cell lines and cultured melanocytes. The most differentially expressed microRNA between the normal and tumor cell lines was miR-211. We focused on this pigment cell enriched miRNA as it is derived from the MITF-regulated gene, TRPM1 (melastatin). We find that miR-211 expression is greatly decreased in melanoma cells and melanoblasts compared to melanocytes. Bioinformatic analysis identified a large number of potential targets of miR-211, including POU3F2 (BRN2). Inhibition of miR-211 in normal melanocytes resulted in increased BRN2 protein, indicatin... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4653045 Thu, 17 Mar 2011 00:00:00 +0100 4653045 http://www.medworm.com/index.php?rid=4610649&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21410905%26dopt%3DAbstract Authors: Serrano CH, Sánchez-Laorden BL, Jiménez-Cervantes C, García-Borrón JC The melanocortin 1 receptor (MC1R), a major determinant of skin pigmentation and phototype, mediates the actions of α melanocyte-stimulating hormone on melanocytes and is critical for melanocyte proliferation and differentiation. MC1R has two putative N-glycosylation targets, Asn15 and Asn29. It has been shown that MC1R is a glycoprotein with an unusual sensitivity to endoglycosidase H digestion. However, the occupancy and functional importance of each specific glycosylation sequon remains unknown. We demonstrate that MC1R is N-glycosylated at Asn15 and Asn29, with structurally and functionally different glycan chains. N-glycosylation is not necessary for high affinity agonist binding or functional coup... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4610649 Wed, 16 Mar 2011 00:00:00 +0100 4610649 http://www.medworm.com/index.php?rid=4610651&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21410653%26dopt%3DAbstract Authors: Bennett D PMID: 21410653 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4610651 Tue, 15 Mar 2011 00:00:00 +0100 4610651 http://www.medworm.com/index.php?rid=4610650&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21410654%26dopt%3DAbstract Authors: Zabierowski SE, Fukunaga-Kalabis M, Li L, Herlyn M Human multipotent dermal stem cells (DSC) have been isolated and propagated from the dermal region of neonatal foreskin. DSC can self-renew, express the neural crest stem cell markers NGFRp75 and nestin, and are capable of differentiating into a wide variety of cell types including mesenchymal and neuronal lineages and melanocytes, indicative of their neural crest origin. When placed in the context of reconstructed skin, DSCs migrate to the basement membrane zone and differentiate into melanocytes. These findings, combined with the identification of NGFRp75-positive cells in the dermis of human foreskin, which are devoid of hair, suggest that DSC may be a self-renewing source of extrafollicular epidermal melanocytes. In this r... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4610650 Tue, 15 Mar 2011 00:00:00 +0100 4610650 http://www.medworm.com/index.php?rid=4577856&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21392364%26dopt%3DAbstract Authors: Ronai Z PMID: 21392364 [PubMed - in process] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4577856 Sun, 13 Mar 2011 05:36:20 +0100 4577856 http://www.medworm.com/index.php?rid=4577855&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21392365%26dopt%3DAbstract Authors: Hoyle DJ, Rodriguez-Fernandez IA, Dell'angelica EC The biogenesis of melanosomes is a multistage process that requires the function of cell-type-specific and ubiquitously expressed proteins. OCA2, the product of the gene defective in oculocutaneous albinism type 2, is a melanosomal membrane protein with restricted expression pattern and a potential role in the trafficking of other proteins to melanosomes. The ubiquitous protein complexes AP-3, BLOC-1, and BLOC-2, which contain as subunits the products of genes defective in various types of Hermansky-Pudlak syndrome, have been likewise implicated in trafficking to melanosomes. We have tested for genetic interactions between mutant alleles causing deficiency in OCA2 (pink-eyed dilution unstable), AP-3 (pearl), BLOC-1 (pallid), a... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4577855 Sun, 13 Mar 2011 05:36:17 +0100 4577855 http://www.medworm.com/index.php?rid=4577854&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21392366%26dopt%3DAbstract Authors: McMahon M PMID: 21392366 [PubMed - in process] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4577854 Sun, 13 Mar 2011 05:36:13 +0100 4577854 http://www.medworm.com/index.php?rid=4577853&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21392367%26dopt%3DAbstract Authors: Gunn TM PMID: 21392367 [PubMed - in process] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4577853 Sun, 13 Mar 2011 05:36:09 +0100 4577853 http://www.medworm.com/index.php?rid=4577852&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21392368%26dopt%3DAbstract Authors: Zaidi MR, Hornyak TJ, Merlino G PMID: 21392368 [PubMed - in process] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4577852 Sun, 13 Mar 2011 05:36:04 +0100 4577852 http://www.medworm.com/index.php?rid=4559986&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21375698%26dopt%3DAbstract Authors: Hirobe T Coat colors are determined by melanin (eumelanin and pheomelanin) which is synthesized in melanocytes and accumulates in special organelles, melanosomes, which upon maturation are transferred to keratinocytes. Melanocytes differentiate from undifferentiated precursors, called melanoblasts, that are derived from neural crest cells. Melanoblast/melanocyte proliferation and differentiation are regulated by the tissue environment, especially by keratinocytes, which synthesize endothelins, steel factor, hepatocyte growth factor, leukemia inhibitory factor and granulocyte-macrophage colony-stimulating factor. Melanocytes differentiation is also stimulated by Alpha-melanocyte stimulating hormone which in the mouse, however, is likely carried through the blood stream and not ... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4559986 Fri, 04 Mar 2011 00:00:00 +0100 4559986 http://www.medworm.com/index.php?rid=4591853&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21396083%26dopt%3DAbstract Authors: Sharp PA PMID: 21396083 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4591853 Fri, 18 Feb 2011 00:00:00 +0100 4591853 http://www.medworm.com/index.php?rid=4524995&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21324100%26dopt%3DAbstract Conclusion:  The findings indicate that BRAF-mutated melanomas arise early in life at low cumulative UV doses, whereas melanomas without BRAF mutations require accumulation of high UV doses over time, resulting in solar elastosis. The effect of anatomic site on the mutation spectrum further suggests regional differences among cutaneous melanocytes. PMID: 21324100 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4524995 Wed, 16 Feb 2011 00:00:00 +0100 4524995 http://www.medworm.com/index.php?rid=4524994&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21324101%26dopt%3DAbstract We present a literature review on the currently known facts about KP in vitiligo, including details of clinical, experimental and histopathological changes. The consensus view is that there are still no methods to define and assess KP in vitiligo. A new classification is proposed to allow an evaluation of KP in daily practice or in experimental studies. However, many unanswered questions still remain after redefining KP in patients with vitiligo. Active research focusing on KP in vitiligo may not only provide unexpected clues in the pathogenesis of vitiligo but also help to tailor novel therapies against this chronic and often psychologically devastating skin disease. PMID: 21324101 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4524994 Wed, 16 Feb 2011 00:00:00 +0100 4524994 http://www.medworm.com/index.php?rid=4524993&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21324102%26dopt%3DAbstract Authors: Richardson J, Zeng Z, Ceol C, Mione M, Jackson IJ, Elizabeth Patton E PMID: 21324102 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4524993 Wed, 16 Feb 2011 00:00:00 +0100 4524993 http://www.medworm.com/index.php?rid=4482635&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21320292%26dopt%3DAbstract Authors: Jilaveanu LB, Zito CR, Aziz SA, Chakraborty A, Davies MA, Camp RL, Rimm DL, Dudek A, Sznol M, Kluger HM PMID: 21320292 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4482635 Tue, 15 Feb 2011 00:00:00 +0100 4482635 http://www.medworm.com/index.php?rid=4482634&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21320293%26dopt%3DAbstract Authors: Easty DJ, Gray SG, O'Byrne KJ, O'Donnell D, Bennett DC Receptor tyrosine kinases (RTKs) and their downstream signalling pathways have long been hypothesized to play key roles in melanoma development. A decade ago, evidence was derived largely from animal models, RTK expression studies and detection of activated RAS isoforms in a small fraction of melanomas. Predictions that overexpression of specific RTKs implied increased kinase activity and that some RTKs would show activating mutations in melanoma were largely untested. However, technological advances including rapid gene sequencing, siRNA methods and phospho-RTK arrays now give a more complete picture. Mutated forms of RTK genes including KIT, ERBB4, the EPH and FGFR families and others are known in melanoma. Additional ov... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4482634 Tue, 15 Feb 2011 00:00:00 +0100 4482634 http://www.medworm.com/index.php?rid=4470211&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21310010%26dopt%3DAbstract Authors: Sommer L The neural crest is a transient structure in vertebrate embryos that generates multiple neural and mesenchymal cell types as well as melanocytes. Melanocytes in the skin either derive directly from neural crest cells populating the skin via a dorsolateral migratory pathway or arise by detaching from nerves innervating the skin. Several transcription factors, such as FoxD3, Sox10, Pax3, and Mitf, take part in a genetic network regulating melanocyte formation from the neural crest. The activity of these intrinsic factors is controlled and modulated by extracellular signals including canonical Wnt, Edn, Kitl, and other signals that remain to be identified. Here we summarize the current view of how melanocytes are specified from the neural crest and put this process into ... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4470211 Thu, 10 Feb 2011 00:00:00 +0100 4470211 http://www.medworm.com/index.php?rid=4436562&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21290790%26dopt%3DAbstract Authors: Mitra D, Robinson KC, Fisher DE PMID: 21290790 [PubMed - in process] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4436562 Tue, 01 Feb 2011 00:00:00 +0100 4436562 http://www.medworm.com/index.php?rid=4382564&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21232023%26dopt%3DAbstract Authors: Hersey P, Smalley KS, Weeraratna A, Bosenberg M, Zhang XD, Haass NK, Paton E, Mann G, Scolyer RA The 2010 7th International Melanoma Congress sponsored by the Society for Melanoma Research and held in Sydney, Australia, was held together with the International Melanoma and Skin Cancer Centers group and the International Melanoma Pathology Study Group. As a consequence, there were over 900 registrants that included a wide range of clinicians (surgeons, medical oncologists, dermatologists) specialising in the management of melanoma as well as scientists and students carrying out laboratory-based research in melanoma. There was a general consensus that this grouping of clinicians, pathologists and scientists was mutually advantageous and plans are afoot to continue this grouping ... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4382564 Sat, 22 Jan 2011 01:50:47 +0100 4382564 http://www.medworm.com/index.php?rid=4382563&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21232024%26dopt%3DAbstract Authors: Ronai Z PMID: 21232024 [PubMed - in process] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4382563 Sat, 22 Jan 2011 01:50:43 +0100 4382563 http://www.medworm.com/index.php?rid=4382562&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21232025%26dopt%3DAbstract Authors: Flaherty KT PMID: 21232025 [PubMed - in process] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4382562 Sat, 22 Jan 2011 01:50:38 +0100 4382562 http://www.medworm.com/index.php?rid=4382561&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21232026%26dopt%3DAbstract Authors: Aruta C, Giordano F, De Marzo A, Comitato A, Raposo G, Nandrot EF, Marigo V One of the limitations in molecular and functional studies of the retinal pigment epithelium (RPE) has been the lack of an in vitro system retaining all the features of in vivo RPE cells. Retinal pigment epithelium cell lines do not show characteristics typical of a functional RPE, such as pigmentation and expression of specific markers. The present study was aimed at the development of culture conditions to differentiate, in vitro, retinal stem cells (RSC), derived from the adult ciliary body, into a functional RPE. Retinal stem cells were purified from murine eyes, grown as pigmented neurospheres and induced to differentiate into RPE on an extracellular matrix substrate using specific culture conditi... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4382561 Sat, 22 Jan 2011 01:50:33 +0100 4382561 http://www.medworm.com/index.php?rid=4382560&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21232027%26dopt%3DAbstract Authors: Hirobe T, Ito S, Wakamatsu K The mouse pink-eyed dilution (p) locus is known to control eumelanin synthesis, melanosome morphology, and tyrosinase activity in melanocytes. However, it has not been fully determined whether the mutant allele, p affects pheomelanin synthesis. Effects of the p allele on eumelanin and phemelanin synthesis were investigated by chemical analysis of dorsal hairs of 5-week-old mice obtained from the F(2) generations (black, pink-eyed black, recessive yellow, pink-eyed recessive yellow, agouti, and pink-eyed agouti) between C57BL/10JHir (B10)-congenic pink-eyed black mice (B10-p/p) and recessive yellow (B10-Mc1r(e) /Mc1r(e) ) or agouti (B10-A/A) mice. The eumelanin content was dramatically (>20-fold) decreased in pink-eyed black and pink-eyed agouti ... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4382560 Sat, 22 Jan 2011 01:50:29 +0100 4382560 http://www.medworm.com/index.php?rid=4382559&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21232028%26dopt%3DAbstract Authors: Wakamatsu K, Hearing V PMID: 21232028 [PubMed - in process] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4382559 Sat, 22 Jan 2011 01:50:24 +0100 4382559 http://www.medworm.com/index.php?rid=4559987&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21375697%26dopt%3DAbstract Authors: Conway K, Edmiston SN, Khondker ZS, Groben PA, Zhou X, Chu H, Kuan PF, Hao H, Carson C, Berwick M, Olilla DW, Thomas NE DNA methylation, an epigenetic alteration typically occurring early in cancer development, could aid in the molecular diagnosis of melanoma. We determined technical feasibility for high-throughput DNA-methylation array-based profiling using formalin-fixed paraffin-embedded tissues for selection of candidate DNA-methylation differences between melanomas and nevi. Promoter methylation was evaluated in 27 common benign nevi and 22 primary invasive melanomas using a 1505 CpG site microarray. Unsupervised hierarchical clustering distinguished melanomas from nevi; 26 CpG sites in 22 genes were identified with significantly different methylation levels between melan... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4559987 Fri, 21 Jan 2011 00:00:00 +0100 4559987 http://www.medworm.com/index.php?rid=4349384&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21226857%26dopt%3DAbstract Authors: Day CP, Merlino G PMID: 21226857 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4349384 Wed, 12 Jan 2011 00:00:00 +0100 4349384 http://www.medworm.com/index.php?rid=4324761&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21210960%26dopt%3DAbstract Authors: Gunnarsson U, Kerje S, Bed'hom B, Sahlqvist AS, Ekwall O, Tixier-Boichard M, Kämpe O, Andersson L The Dark brown mutation in chickens reduces expression of black eumelanin and enhances expression of red pheomelanin but only in certain parts of the plumage. Here we present genetic evidence that an 8.3 kb deletion upstream of the SOX10 transcription start site is the causal mutation underlying the Dark brown phenotype. The SOX10 transcription factor has a well-established role in melanocyte biology and is essential for melanocyte migration and survival. Previous studies have demonstrated that the mouse homolog of a highly conserved element within the deleted region is a SOX10 enhancer. The mechanism of action of this mutation remains to be established but one possible scenario ... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4324761 Thu, 06 Jan 2011 00:00:00 +0100 4324761 http://www.medworm.com/index.php?rid=4294238&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21176117%26dopt%3DAbstract Authors: Zipser MC, Eichhoff OM, Widmer DS, Schlegel NC, Schoenewolf NL, Stuart D, Liu W, Gardner H, Smith PD, Nuciforo P, Dummer R, Hoek KS Oncogenic mutations within the MAPK pathway are frequent in melanoma and targeting of MAPK signalling has yielded spectacular responses in a significant number of patients that last for several months before relapsing. We investigated the effects of two different inhibitors of MAPK signalling in proliferative and invasive melanoma cell cultures with various mutations in the MAPK pathway. Proliferative melanoma cells were more susceptible to pathway inhibition than invasive phenotype cells, irrespective of BRAF mutation status, while invasive phenotype cell response was dependent on BRAF mutation status. Critically, MAPK pathway inhibition of proli... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4294238 Wed, 22 Dec 2010 00:00:00 +0100 4294238 http://www.medworm.com/index.php?rid=4265310&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21159145%26dopt%3DAbstract Authors: Besaratinia A, Pfeifer GP PMID: 21159145 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4265310 Wed, 15 Dec 2010 00:00:00 +0100 4265310 http://www.medworm.com/index.php?rid=4265309&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21159146%26dopt%3DAbstract Authors: McDonnell K, Betz B, Fullen D, Lao CD PMID: 21159146 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4265309 Wed, 15 Dec 2010 00:00:00 +0100 4265309 http://www.medworm.com/index.php?rid=4265311&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21143770%26dopt%3DAbstract Authors: Giuliano S, Ohanna M, Ballotti R, Bertolotto C Normal cells possess a limited proliferative life span after which they enter a state of irreversible growth arrest called replicative senescence that acts as a potent barrier against transformation. Transformed cells have escaped the process of replicative senescence and could theoretically not re-enter senescence. However, recent observations have shown that transformed cells and particularly the melanoma cells can still undergo oncogene or stress-induced senescence. This senescence state is accompanied by many of the markers associated with replicative senescence such as flattened shape, increased acidic β-galactosidase activity (SA-β-gal), characteristic changes in gene expression and growth arrest. Interestingly, in some ca... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4265311 Sat, 11 Dec 2010 00:00:00 +0100 4265311 http://www.medworm.com/index.php?rid=4245156&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21138545%26dopt%3DAbstract Authors: Wagner W, Hammer JA PMID: 21138545 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4245156 Tue, 07 Dec 2010 00:00:00 +0100 4245156 http://www.medworm.com/index.php?rid=4245160&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21129163%26dopt%3DAbstract Authors: Aplin AE, Sato T PMID: 21129163 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4245160 Fri, 03 Dec 2010 00:00:00 +0100 4245160 http://www.medworm.com/index.php?rid=5107232&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21823251%26dopt%3DAbstract Authors: Steingrímsson E SUMMARY: Mutations provide important structure–function relationships by allowing the correlation of phenotypes to the underlying genotypes. Knockout mutations that lead to loss-of-function are important and informative in this respect. However, spontaneous and induced mutations sometimes provide surprising phenotypes, which lead to unexpected functional insights and novel biochemical pathways, especially when multiple mutations(alleles) exist at a locus. An excellent example is provided by the microphthalmia (Mitf) locus in the mouse.The multiple Mitf alleles have their own phenotypic properties, most of which have been explained by the underlying mutation. However, one allele, the Mitf (Mi-White) (Mitf (Mi-Wh)) mutation, exhibits phenotypes that have not y... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=5107232 Wed, 01 Dec 2010 00:00:00 +0100 5107232 http://www.medworm.com/index.php?rid=4911233&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21644263%26dopt%3DAbstract Authors: HuangFu WC, Qian J, Liu C, Rui H, Fuchs SY PMID: 21644263 [PubMed - in process] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4911233 Wed, 01 Dec 2010 00:00:00 +0100 4911233 http://www.medworm.com/index.php?rid=4445605&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20973937%26dopt%3DAbstract Authors: PMID: 20973937 [PubMed - indexed for MEDLINE] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4445605 Wed, 01 Dec 2010 00:00:00 +0100 4445605 http://www.medworm.com/index.php?rid=4445604&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20973938%26dopt%3DAbstract Authors: PMID: 20973938 [PubMed - indexed for MEDLINE] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4445604 Wed, 01 Dec 2010 00:00:00 +0100 4445604 http://www.medworm.com/index.php?rid=4229094&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21118390%26dopt%3DAbstract Authors: Berwick M PMID: 21118390 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4229094 Tue, 30 Nov 2010 00:00:00 +0100 4229094 http://www.medworm.com/index.php?rid=4229093&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21118391%26dopt%3DAbstract Authors: Metz HC, Manceau M, Hoekstra HE PMID: 21118391 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4229093 Tue, 30 Nov 2010 00:00:00 +0100 4229093 http://www.medworm.com/index.php?rid=4245162&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21129162%26dopt%3DAbstract Authors: Jackson IJ PMID: 21129162 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4245162 Fri, 26 Nov 2010 00:00:00 +0100 4245162 http://www.medworm.com/index.php?rid=4219542&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21108769%26dopt%3DAbstract Authors: Paus R The role of neurohormones and neuropeptides in human hair follicle (HF) pigmentation extends far beyond the control of melanin synthesis by a-MSH and ACTH. and includes e.g. melanoblast differentiation, reactive oxygen species scavenging, maintenance of HF immune privilege, and remodelling of the HF pigmentary unit (HFPU). It is now clear that human HFs are not only a target of multiple neuromediators, but also are a major non-classical production site for neurohormones such as CRH, POMC, ACTH, a-MSH, ß-endorphin, TRH and melatonin. Moreover, human HFs have established a functional peripheral equivalent of the hypothalamic-pituitary-adrenal axis. By charting the author's own meanderings through the jungle of hair pigmentation research, the current perspectives essay ut... Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4219542 Thu, 25 Nov 2010 00:00:00 +0100 4219542 http://www.medworm.com/index.php?rid=4203081&cid=s_38171_171_f&fid=38171&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21091638%26dopt%3DAbstract Authors: Koefinger P, Wels C, Joshi S, Damm S, Steinbauer E, Beham-Schmid C, Frank S, Bergler H, Schaider H PMID: 21091638 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research) Pigment Cell and Melanoma Research journals http://www.medworm.com/rss/comments.php?id=4203081 Fri, 19 Nov 2010 00:00:00 +0100 4203081