MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Planta Medica' source. Wed, 08 Feb 2012 14:04:29 +0100 http://www.medworm.com/index.php?rid=5667528&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1298254 Planta MedDOI: 10.1055/s-0031-1298254AbstractThree new triterpenoid saponins, 1–3, together with two known saponins, 4 and 5, were isolated from the rhizome of Ardisia gigantifolia. Their structures were elucidated by 1D and 2D NMR spectroscopic studies. Saponins 1, 2, 4, and 5 exhibited significant cytotoxicity against four human cancer cell lines, namely, Hela human cervical carcinoma cells, EJ human bladder tumor cells, HepG-2 human hepatoma cells, and BCG human gastric carcinoma cells with IC50 values in the range of 1.9–4.8 µM.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Planta Medica) Planta Medica journals http://www.medworm.com/rss/comments.php?id=5667528 Tue, 07 Feb 2012 05:00:00 +0100 5667528 http://www.medworm.com/index.php?rid=5667527&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1298240 This study indicates that metabolites of Rhizoma Coptidis vary with the species and the proposed method is suitable for metabolic fingerprinting analysis to check the genuine origin of Rhizoma Coptidis.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Planta Medica) Planta Medica journals http://www.medworm.com/rss/comments.php?id=5667527 Tue, 07 Feb 2012 05:00:00 +0100 5667527 http://www.medworm.com/index.php?rid=5660217&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1298242 Planta MedDOI: 10.1055/s-0031-1298242AbstractThe inhibition of protein tyrosine phosphatase 1B (PTP1B) is considered a valid strategy to combat insulin resistance and type II diabetes. We show here that a dichloromethane extract of Ratanhiae radix (RR_ex) dose-dependently inhibits human recombinant PTP1B in vitro and enhances insulin-stimulated glucose uptake in murine myocytes. By determination of the PTP1B inhibiting potential of 11 recently isolated lignan derivatives from RR_ex, the observed activity of the extract could be partly assigned to ratanhiaphenol III. This compound inhibited PTP1B in vitro with an IC50 of 20.2 µM and dose-dependently increased insulin receptor phosphorylation as well as insulin-stimulated glucose uptake in cultured myotubes. This is the first report to re... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5660217 Fri, 03 Feb 2012 05:00:00 +0100 5660217 http://www.medworm.com/index.php?rid=5660216&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1298228 Planta MedDOI: 10.1055/s-0031-1298228AbstractThree new depsidones (1, 3, and 4), a new diaryl ether (5), and a new natural pyrone (9) (synthetically known), together with three known depsidones, nidulin (6), nornidulin (7), and 2-chlorounguinol (8), were isolated from the marine-derived fungus Aspergillus unguis CRI282-03. Aspergillusidone C (4) showed the most potent aromatase inhibitory activity with the IC50 value of 0.74 µM, while depsidones 1, 3, 6–8 inhibited aromatase with IC50 values of 1.2–11.2 µM. It was found that the structural feature of depsidones, not their corresponding diaryl ether derivatives (e.g. 5), was important for aromatase inhibitory activity. Aspergillusidones A (1) and B (3) showed radical scavenging activity in the XXO assay with IC50 values of 16.0 an... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5660216 Fri, 03 Feb 2012 05:00:00 +0100 5660216 http://www.medworm.com/index.php?rid=5660215&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1298223 Planta MedDOI: 10.1055/s-0031-1298223AbstractFive new steroidal glycosides, timosaponin J (1), timosaponin K (2), (25S)-karatavioside C (5), timosaponin L (6), and (25S)-officinalisnin-I (8), together with eight known steroidal saponins, timosaponin E1 (3), purpureagitosid (4), timosaponin BII (7), timosaponin B III (9), anemarrhenasaponin I (10), anemarrhenasaponin III (11), anemarrhenasaponin A2 (12), and timosaponin A III (13), were isolated from the rhizomes of Anemarrhena asphodeloides. Their structures were elucidated on the basis of spectroscopic and chemical evidence. The aglycones of compounds 1 and 2 are new aglycones. Compounds 1–13 were evaluated for their platelet aggregation activities, and compound 13 exhibited the strongest inhibitory effect on adenosine diphosphate (ADP)... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5660215 Fri, 03 Feb 2012 05:00:00 +0100 5660215 http://www.medworm.com/index.php?rid=5660214&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1298238 In this study, we developed a highly sensitive liquid chromatography-tandem MS method to determine the ardipusilloside I concentration in rat plasma using ginsenoside Re (whose structure is similar to ardipusilloside I) as the internal standard. After oral administration of ardipusilloside I, its four possible metabolites (M1, M2, M3, and M4, whose structures were determined by MS) were detected in the content from rat small intestine. In rat plasma, however, only M3 and M4 were detected after oral administration of ardipusilloside I. None of the metabolites were detected in plasma samples after intravenous administration of ardipusilloside I to rats. These results indicated that the metabolites, but not the drug itself, were absorbed into plasma after oral administration of ardipusillosid... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5660214 Fri, 03 Feb 2012 05:00:00 +0100 5660214 http://www.medworm.com/index.php?rid=5648649&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1298229 Planta MedDOI: 10.1055/s-0031-1298229AbstractEtOAc extracts from two batches of Morus alba root bark (Sang bai pi) potentiated γ-aminobutyric acid (GABA)-induced chloride influx in Xenopus oocytes, which transiently expressed GABAA receptors of the subunit composition α1β2γ2S. With the aid of HPLC-based activity profiling of the extract from the first batch, activity was traced to a peak subsequently identified as sanggenon G (3). The second batch had a different phytochemical profile, and HPLC-based activity profiling led to the identification of sanggenon C (4) and a stereoisomer of sanggenon D (2) as positive GABAA receptor modulators. The structurally related compound kuwanon L (1) was inactive. The sanggenons represent a new scaffold of positive GABAA receptor modulators.[...]© G... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5648649 Tue, 31 Jan 2012 05:00:00 +0100 5648649 http://www.medworm.com/index.php?rid=5648648&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1298215 Planta MedDOI: 10.1055/s-0031-1298215AbstractThree new diterpenoids, 18-formyloxy-8β-hydroxysandaracopimar-15-ene (1), 15(R)-n-butoxypinusolidic acid (2), and 15,16-dihydro-15,16-dimethoxylambertianic acid (3), along with twelve known compounds (4–15) were isolated from MeOH extracts of leaves of Thuja orientalis L. The structures of the three new compounds were elucidated on the basis of spectroscopic analyses, including extensive 2D-NMR data. The absolute stereochemistry of compound 2 was clarified by a CD spectroscopic study. The isolated compounds were evaluated for cytotoxicity against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines in vitro using the sulforhodamin B (SRB) bioassay.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5648648 Tue, 31 Jan 2012 05:00:00 +0100 5648648 http://www.medworm.com/index.php?rid=5638820&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1298201 Planta MedDOI: 10.1055/s-0031-1298201AbstractFour new tetrahydrofuranoid lignans, (−)-tanegool-7′-methyl ether (1), (+)-7′-methoxylariciresinol (2), sinolignan C (3), and epipinoresinol-4,4′-di-O-β-D-glucopyranoside (4), were isolated from the roots and rhizomes of Sinopodophyllum emodi together with one known lignan (5). Their structures and stereochemistry were elucidated on the basis of spectroscopic and mass spectrometric evidence. The isolation of compounds 1–5 represents the first report of tetrahydrofuran lignans from the genus Sinopodophyllum. The cytotoxic activities of all isolated compounds were evaluated against HeLa and KB cell lines, and compound 1 showed the most potent cytotoxicity with IC50 values of 9.7 µM and 4.7 µM, respectively.[...]© Georg Thieme Ver... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5638820 Thu, 26 Jan 2012 05:00:00 +0100 5638820 http://www.medworm.com/index.php?rid=5638819&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1298214 Planta MedDOI: 10.1055/s-0031-1298214AbstractTen new triterpenoids, schiglausins A–J (1–10), as well as four known compounds, were isolated from the stems of Schisandra glaucescens. Their structures were elucidated on the basis of spectroscopic methods, including extensive NMR spectra and CD experiment. Compound 8 was determined to be a norlanostane triterpenoid. The crystal structure of compound 1 has been determined using single-crystal X-ray analysis while its absolute configuration was assigned on the basis of the CD spectrum. All isolates were tested for their FXR agonistic and antagonistic effects.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Planta Medica) Planta Medica journals http://www.medworm.com/rss/comments.php?id=5638819 Thu, 26 Jan 2012 05:00:00 +0100 5638819 http://www.medworm.com/index.php?rid=5629140&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1298155 Planta MedDOI: 10.1055/s-0031-1298155AbstractThe terpene alcohols geranyllinalool, phytol (diterpene alcohol), and farnesol (sesquiterpene alcohol) were newly found to inhibit sphingolipid de novo biosynthesis in LLC-PK1 cells (pig kidney epithelial cells). A simple chromatographic bioassay was established for the screening of inhibitory compounds able to reduce the amount of sphinganine, an intermediate metabolite of sphingolipid biosynthesis. The screening strategy was based on the degree of suppression of fumonisin B1 (FB1)-induced sphinganine accumulation following co-treatment with selected terpene alcohols. L-cycloserine and ISP-1, specific serine palmitoyltransferase (SPT) inhibitors, were used as positive controls. Our results show that measuring reduced sphinganine levels after tr... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5629140 Tue, 24 Jan 2012 05:00:00 +0100 5629140 http://www.medworm.com/index.php?rid=5629137&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1298172 This study aimed to evaluate its gastroprotective and anti-inflammatory activities. Besides, continuously increasing interest in assessing the role of the plant active constituents preventing the risk of cancer was a reason to make a detailed examination of the investigated ethanol, diethyl ether, ethyl acetate, and n-butanol extracts regarding cytotoxicity. Oral administration of the investigated extracts caused a dose-dependent anti-inflammatory effect in a model of carrageenan-induced rat paw edema. Gastroprotective activity of the extracts was investigated using an ethanol-induced acute stress ulcer in rats. The cytotoxic activity of plant extracts was assessed on PBMC, B16, and HL-60 cells and compared to the cytotoxicity of phenolic compounds identified in extracts. Apoptotic and nec... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5629137 Tue, 24 Jan 2012 05:00:00 +0100 5629137 http://www.medworm.com/index.php?rid=5629134&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1298173 In this study, the antitumor activity of the essential oil from the leaves of G. friesiana (EOGF) and its main components (α-, β-, and γ-eudesmol) were determined using experimental models. In the in vitro study, EOGF and its components α-, β-, and γ-eudesmol displayed cytotoxicity against tumor cell lines, showing IC50 values in the range of 1.7 to 9.4 µg/mL in the HCT-8 and HL-60 cell lines for EOGF, 5.7 to 19.4 µg/mL in the HL-60 and MDA-MB-435 cell lines for α-eudesmol, 24.1 to > 25 µg/mL in the SF-295 and MDA-MB-435 cell lines for β-eudesmol, and 7.1 to 20.6 µg/mL in the SF-295 and MDA-MB-435 cell lines for γ-eudesmol, respectively. In the in vivo study, the antitumor effect of EOGF was evaluated in mice inoculated with sarcoma 180 tumor cells. Tumor growth i... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5629134 Tue, 24 Jan 2012 05:00:00 +0100 5629134 http://www.medworm.com/index.php?rid=5629141&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1298171 Planta MedDOI: 10.1055/s-0031-1298171AbstractIn a two–microelectrode voltage clamp assay using Xenopus laevis oocytes, a petroleum ether extract prepared from a commercial sample of the traditional Chinese herbal drug labelled as “Chaihu” (Bupleurum chinense DC. roots) enhanced the IGABA by 156 % ± 22 % when tested at 100 µg/mL. By means of HPLC-based activity profiling combined with high-resolution LC-MS and microprobe NMR, the germacranolide aristolactone (1) was identified as one of the main active compounds (EC50 56.02 µM ± 5.09 µM). However, aristolactone has been previously reported only from the genus Aristolochia (Aristolochiaceae), suggesting a possible adulteration. With the aid of a validated HPTLC protocol for detection of aristolochic acids and with ... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5629141 Mon, 23 Jan 2012 05:00:00 +0100 5629141 http://www.medworm.com/index.php?rid=5629139&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1298174 Planta MedDOI: 10.1055/s-0031-1298174AbstractThe gamma-amino butyric acid (GABA) type A (GABAA) receptor represents a crucial target for clinical agents in the treatment of anxiety and insomnia. Using the two-microelectrode voltage clamp technique on recombinant α1β2γ2S GABAA receptors, effusol (1) and dehydroeffusol (2) were isolated in a bioactivity-guided approach from the pith of Juncus effusus L. Both compounds concentration-dependently enhanced GABA induced chloride currents (IGABA) by a maximum 188 ± 20 (1) and 239 ± 18 % (2), independent of the benzodiazepine (BZ) binding site. This activity on the GABAA receptor may explain the traditional use of J. effusus as a sedative and anxiolytic agent in Chinese medicine.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArt... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5629139 Mon, 23 Jan 2012 05:00:00 +0100 5629139 http://www.medworm.com/index.php?rid=5629138&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1298156 Planta MedDOI: 10.1055/s-0031-1298156AbstractTwo new polyprenylated acylphloroglucinols, spiranthenones A (1) and B (2), a sesquiterpenoid, 6α-acetoxy,1β-hydroxyeudesm-4(15)-ene (3), along with sesamin and β-sitosterol, were isolated from the EtOAc extract of the leaves of Spiranthera odoratissima, and shown to display antiprotozoal activity. Their structures and relative stereochemistry were elucidated by NMR and mass spectrometry. These compounds exhibited moderate antiprotozoal activity, but without significant cytotoxicity against fibroblasts cell line NIH-3T3. Compound 3 was the most selective towards parasites.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Planta Medica) Planta Medica journals http://www.medworm.com/rss/comments.php?id=5629138 Mon, 23 Jan 2012 05:00:00 +0100 5629138 http://www.medworm.com/index.php?rid=5629136&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1298175 Planta MedDOI: 10.1055/s-0031-1298175AbstractFive selaginellin derivatives, including two new selaginellins termed selaginellins M (1) and N (2), and three previously identified compounds, selaginellin (3), selaginellin A (4), and selaginellin C (5), were isolated from the Selaginella tamariscina (Beauv.) Spring plant. In addition, four known biflavonoids, namely neocryptomerin (6), hinokiflavone (7), pulvinatabiflavone (8), and 7′′-O-methylamentoflavone (9), were also isolated. The structures of new compounds 1 and 2 were elucidated by spectroscopic analysis. The cytotoxic activity of compounds 1-9 was evaluated against a small panel of human cancer cell lines, including U251 (human glioma cells), HeLa (human cervical carcinoma cells), and MCF-7 (human breast cancer cells). The two ne... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5629136 Mon, 23 Jan 2012 05:00:00 +0100 5629136 http://www.medworm.com/index.php?rid=5629135&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1298170 Planta MedDOI: 10.1055/s-0031-1298170AbstractThe growing interest in the efficacy of phytomedicines and herbal supplements but also the increase in legal requirements for safety and reliable contents of active principles drive the development of analytical methods for the quality control of complex, multicomponent mixtures as found in plant extracts of value for the pharmaceutical industry. Here, we describe an ultra-performance liquid chromatography method (UPLC) coupled with quadrupole time of flight mass spectrometry (qTOF-MS) measurements for the large scale analysis of H. perforatum plant material and its commercial preparations. Under optimized conditions, we were able to simultaneously quantify and identify 21 metabolites including 4 hyperforins, 3 catechins, 3 naphthodianthrones, 5... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5629135 Mon, 23 Jan 2012 05:00:00 +0100 5629135 http://www.medworm.com/index.php?rid=5609381&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1298157 Planta MedDOI: 10.1055/s-0031-1298157AbstractInvestigation of the essential oil of the aerial parts of Eryngium maritimum L. from Corsica led to the isolation of one known sesquiterpene (1) and three new oxygenated sesquiterpenes with a muurolane or cadinane skeleton (2–4). Structure assignments of 4βH-muurol-9-en-15-al (1), 4βH-cadin-9-en-15-al (2), 4βH-muurol-9-en-15-ol (3) and 4βH-cadin-9-en-15-ol (4) were carried out by GC/MS (EI and CI) and comprehensive 1D and 2D NMR spectroscopy. Antibacterial activity of Eryngium maritimum L. oil and column chromatography fractions have been investigated for the first time. The oxygenated fraction, which contains the four sesquiterpenes, was efficient against Listeria monocytogenes and Echerichia coli.[...]© Georg Thieme Verlag KG Stuttg... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5609381 Wed, 18 Jan 2012 05:00:00 +0100 5609381 http://www.medworm.com/index.php?rid=5598234&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280453 Planta MedDOI: 10.1055/s-0031-1280453AbstractStarting from the diterpene (4S,9R,10R) methyl 18-carboxy-labda-8,13(E)-dien-15-oate (PMD) and its 8(9)-en isomer [PMD 8(9)-en], 11 amides were prepared and assessed for a gastroprotective effect in the ethanol/HCl-induced gastric lesions model in mice. Basal cytotoxicity of the compounds was determined on the following human cell lines: normal lung fibroblasts (MRC-5), gastric epithelial adenocarcinoma (AGS), and hepatocellular carcinoma (Hep G2). All compounds are described for the first time. At the single oral dose of 0.1 mg/kg, compounds 1, 10, and 11 presented a strong gastroprotective effect, at least comparable with that of the reference compound lansoprazole at 1 mg/kg, reducing gastric lesions by 76.7, 67.7, and 77.2 %, respectiv... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5598234 Mon, 16 Jan 2012 05:00:00 +0100 5598234 http://www.medworm.com/index.php?rid=5598236&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1298149 Planta MedDOI: 10.1055/s-0031-1298149AbstractSolasodine rhamnosyl glycosides (SRGs) induce apoptosis in a wide variety of cancer cells and are more effective than many well-established anticancer agents. Combination therapy of SRGs with cisplatin treats cisplatin–resistant cells such as lung cancer and breast cancer cells. Anticancer therapies with SRGs have been used intravenously, intraperitoneally, intralesionally, orally, and topically. Data is now presented that in addition to apoptosis and, perhaps as a consequence thereof, SRGs also have an effect of stimulating lasting immunity against cancer as shown with a mouse model and the terminal cancer Sarcoma 180. Mice were inoculated i. p. with Sarcoma 180. Groups of animals were administered SRGs half an hour after Sarcoma 180 inocul... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5598236 Fri, 13 Jan 2012 05:00:00 +0100 5598236 http://www.medworm.com/index.php?rid=5598235&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280472 Planta MedDOI: 10.1055/s-0031-1280472AbstractHepatic stellate cells (HSCs) play a key role in the pathogenesis of liver fibrosis. In chronic liver injury, HSCs undergo transdifferentiation to an activated myofibroblastic phenotype and migrate to injured areas in response to chemotactic factors, producing extracellular matrix proteins such as collagen type I to repair the damage as well as overexpression of α-smooth muscle actin (α-SMA). Paeoniae Radix, the root of Paeonia lactiflora Pall, was investigated for PDGF-BB-induced HSC chemotaxis. Rat HSCs and LX-2, a human HSC cell line, were used for the in vitro experiments. Cell migration was analyzed by wound-healing and transwell assays. An ELISA and a Sircol collagen assay kit were used to detect the expressions of α-SMA and of collagen... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5598235 Fri, 13 Jan 2012 05:00:00 +0100 5598235 http://www.medworm.com/index.php?rid=5598233&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1298146 Planta MedDOI: 10.1055/s-0031-1298146AbstractMultidrug resistance (MDR) of tumor cells is one of the major problems encountered during cancer chemotherapy. In this paper, we isolated eight triterpenoids from Poria cocos and evaluated their effects on reversing MDR of KBV200 cells. Eight triterpenoids increase significantly vincristine-induced cytotoxicity in drug-resistant KBV200 cells at the concentrations of 12.5 µg/mL and 25 µg/mL. Dehydrotumulosic acid showed the best reversal effect: it increased KBV200 apoptosis induced by vincristine and inhibited P-gp function through enhancing the accumulation and retention of fluorescent P-gp substrate rhodamine 123 in KBV200 cells but had no effect on P-gp expression.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJo... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5598233 Fri, 13 Jan 2012 05:00:00 +0100 5598233 http://www.medworm.com/index.php?rid=5582652&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1298143 Planta MedDOI: 10.1055/s-0031-1298143AbstractThe ripe berries of Harrisonia abyssinica yielded two new prenylated acetophenones, namely 5-(ethan-1′′′-one)-4,6-dihydroxy-7-(3′′,3′′-dimethylallyl)-2S-(1′S-hydroxy-1′,5′-dimethylhex-4′-enyl)-2,3-dihydrobenzofuran (1) and 5-(2′′′-hydroxyethan-1′′′-one)-4,6-dihydroxy-7-(3′′,3′′-dimethylallyl)-2S-(1′S-hydroxy-1′,5′-dimethylhex-4′-enyl)-2,3-dihydrobenzofuran (2), herein named harronin I and harronin II, respectively. The compounds were isolated following activity guided fractionation and the structures were determined using 1D, 2D NMR spectroscopic, CD and MS spectrometric techniques. The methanol-dichloromethane mixture (1 : 1 v/v) crude extract exhibited strong antimicrobial activity agai... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5582652 Tue, 10 Jan 2012 05:00:00 +0100 5582652 http://www.medworm.com/index.php?rid=5582650&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1298147 Planta MedDOI: 10.1055/s-0031-1298147AbstractFour new sesquiterpene lactones, (1S,5R,6S,7S,8R,9R,10S,11S)-6-acetoxy-9-hydroxy-4-oxo-pseudoguai-2(3)-en-12,8-olide (1), (1S,2R,5R,6S,7R,8S,10R)-6-acetoxy-2-ethoxy-4-oxo-pseudoguai-11(13)-en-12,8-olide (2), (1S,2R,5R,6S,7R,8S,10R)-6-acetoxy-2-hydroxy-4-oxo-pseudoguai-11(13)-en-12,8-olide (3), and 14-acetoxy-1β,5α,7αH-4β-hydroxy-guai-9(10),11(13)-dien-12,8α-olide (4), along with 26 known sesquiterpene lactones, were isolated from the whole plants of Inula hookeri C. B. Clarke. Their structures were established based on spectroscopic methods including HRESIMS, 1D and 2D NMR, and CD techniques. All compounds were evaluated for their cytotoxic activities against HepG2, HeLa, PC-3, and MGC-803 cell lines by CCK-8 assay. Some of the isolates... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5582650 Tue, 10 Jan 2012 05:00:00 +0100 5582650 http://www.medworm.com/index.php?rid=5582649&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1298136 This study suggests that EEZZ may be an ethnomedicine for improving insulin sensitivity.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Planta Medica) Planta Medica journals http://www.medworm.com/rss/comments.php?id=5582649 Tue, 10 Jan 2012 05:00:00 +0100 5582649 http://www.medworm.com/index.php?rid=5582653&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280418 Planta Med 2012; 78: 1-1DOI: 10.1055/s-0031-1280418© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Full text (Source: Planta Medica) Planta Medica journals http://www.medworm.com/rss/comments.php?id=5582653 Mon, 09 Jan 2012 05:00:00 +0100 5582653 http://www.medworm.com/index.php?rid=5582651&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1298169 Planta Med 2012; 78: 2-5DOI: 10.1055/s-0031-1298169© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Full text (Source: Planta Medica) Planta Medica journals http://www.medworm.com/rss/comments.php?id=5582651 Mon, 09 Jan 2012 05:00:00 +0100 5582651 http://www.medworm.com/index.php?rid=5538359&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280474 Planta MedDOI: 10.1055/s-0031-1280474AbstractDiabetes mellitus type 2 with dyslipidemia is a common disease. Previous studies suggest that aloe (Aloe vera L.) leaf gel may positively affect the blood glucose and lipid levels in dyslipidemic type 2 diabetic patients. Thus, in this randomized double-blind placebo-controlled clinical trial with hyperlipidemic (hypercholesterolemic and/or hypertriglyceridemic) type 2 diabetic patients aged 40 to 60 years not using other anti-hyperlipidemic agents and resistant to daily intake of two 5 mg glyburide tablets and two 500 mg metformin tablets, the efficacy and safety of taking aloe gel (one 300 mg capsule every 12 hours for 2 months) combined with the aforementioned drugs in treatment of 30 patients were evaluated and compared with the placeb... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5538359 Fri, 23 Dec 2011 05:00:00 +0100 5538359 http://www.medworm.com/index.php?rid=5538361&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280455 In conclusion, the present data provide a rational base for the use of the single pharmaceutical preparations from Citrus and Cydonia in a differentiated treatment of allergic disorders in part by the regulation of soluble allergic mediators from basophilic cells and mast cells.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Planta Medica) Planta Medica journals http://www.medworm.com/rss/comments.php?id=5538361 Thu, 22 Dec 2011 05:00:00 +0100 5538361 http://www.medworm.com/index.php?rid=5538360&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280473 Planta MedDOI: 10.1055/s-0031-1280473AbstractFrom the stem bark of Strychnos malacoclados, one new bisindole alkaloid, 3-hydroxylongicaudatine Y (1), was isolated along with the known alkaloids vomicine (2), bisnordihydrotoxiferine (3), divarine (4), longicaudatine (5), longicaudatine Y (6), and longicaudatine F (7). All the compounds were tested for their antimalarial activity against the chloroquine-sensitive 3D7 and -resistant W2 strains of Plasmodium falciparum. Longicaudatine was the most active compound with IC50 values of 0.682 and 0.573 µM, respectively. The activity of compounds 1, 3, 4, 6, and 7 against the two strains ranged from 1.191 to 6.220 µM and 0.573 to 21.848 µM, respectively. Vomicine (2), the only monomer isolated, was inactive. The alkaloids of the longicauda... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5538360 Thu, 22 Dec 2011 05:00:00 +0100 5538360 http://www.medworm.com/index.php?rid=5525321&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280467 Planta MedDOI: 10.1055/s-0031-1280467© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  FREE Full text (Source: Planta Medica) Planta Medica journals http://www.medworm.com/rss/comments.php?id=5525321 Mon, 19 Dec 2011 05:00:00 +0100 5525321 http://www.medworm.com/index.php?rid=5505531&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280448 This study's objective was to evaluate, in a clinical trial, the effectiveness and tolerability of the topical administration of a product elaborated with the standardized extract from the aerial parts of A. pichinchensis in patients with chronic venous leg ulcers, and to compare the effect with a control group treated with 7 % propylene glycol alginate. In this study, a total of 34 patients were included (50 % in each group). Six patients of the control group withdrew from the treatment, three of these because of lack of recovery. In the experimental group, 2 participants withdrew from the study, but none of these due to treatment or clinical-evolution reasons. The A. pichinchensis extract showed therapeutic effectiveness in one hundred percent of the patients treated with it, while... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5505531 Thu, 15 Dec 2011 05:00:00 +0100 5505531 http://www.medworm.com/index.php?rid=5505530&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280449 This study was performed to assess the antiangiogenic activity of 31 medicinal plants grown and sold in Jordan. The antiangiogenic activity was assessed using the rat aortic ring assay. Out of 31 extracts, 15 extracts showed more than 50 % inhibition of the blood vessels outgrowth from the primary tissue explants (p = 0.000). Three of these 15 extracts showed a potential cytotoxic effect on normal fibroblast cells. Four extracts shared antiangiogenic and antiproliferative activity towards MCF7 breast cancer cell lines. Eight extracts demonstrated selective antiangiogenic activity. This is the first report demonstrating the potential antiangiogenic activity of Artemisia judaica, Aloysia citriodora, Salvia egyptiaca, and Calendula arvensis. Some extracts with antiangiogenic activity ex... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5505530 Thu, 15 Dec 2011 05:00:00 +0100 5505530 http://www.medworm.com/index.php?rid=5505529&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280454 Planta MedDOI: 10.1055/s-0031-1280454AbstractSalvialeriafone (1), a novel diterpene-norditerpene conjugate, was isolated from Salvia leriaefolia. Additionally, two new abietane-type diterpenoids, salvialerial (2) and salvialerione (3), as well as four known compounds, sugiol (4), salvicanaric acid (5), dehydroroyleanone (6), and cariocal (7), were isolated and identified. Their structures were determined by spectroscopic data analyses. Known compounds were isolated from this plant for the first time. Compounds 1, 5, 6, and 7 exhibited in vitro antiproliferative activity against the human cervical cancer cell line (Hela), while 6 showed cytotoxicity against the human prostate cancer cell line (PC3).[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of cont... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5505529 Thu, 15 Dec 2011 05:00:00 +0100 5505529 http://www.medworm.com/index.php?rid=5505528&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280430 In this study, ten anthra-, nine naphtho-, and five benzoquinone compounds of natural origin and five synthetic naphthoquinones were assessed, using an enzymatic in vitro assay, for their potential to inhibit cyclooxygenase-1 and -2 (COX-1 and COX-2), the key enzymes of the arachidonic acid cascade. IC50 values comparable with COX reference inhibitor indomethacin were recorded for several quinones (primin, alkannin, diospyrin, juglone, 7-methyljuglone, and shikonin). For some of the compounds, we suggest the redox potential of quinones as the mechanism responsible for in vitro COX inhibition because of the quantitative correlation with their pro-oxidant effect. Structure-relationship activity studies revealed that the substitutions at positions 2 and 5 play the key roles in the COX inhibit... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5505528 Thu, 15 Dec 2011 05:00:00 +0100 5505528 http://www.medworm.com/index.php?rid=5505532&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280434 Planta Med 2011; 77: 1969-1969DOI: 10.1055/s-0031-1280434© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Full text (Source: Planta Medica) Planta Medica journals http://www.medworm.com/rss/comments.php?id=5505532 Wed, 14 Dec 2011 05:00:00 +0100 5505532 http://www.medworm.com/index.php?rid=5495108&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280431 This study investigated the buccal permeability properties of didanosine (ddI) and assessed the potential of Aloe vera gel (AVgel) as a novel buccal permeation enhancer. Permeation studies were performed using Franz diffusion cells, and the drug was quantified by UV spectroscopy. Histomorphological evaluations were undertaken using light and transmission electron microscopy. The permeability of ddI was concentration-dependent, and it did not have any adverse effects on the buccal mucosae. A linear relationship (R2 = 0.9557) between the concentrations and flux indicated passive diffusion as the mechanism of drug transport. AVgel at concentrations of 0.25 to 2 %w/v enhanced ddI permeability with enhancement ratios from 5.09 (0.25 %w/v) to 11.78 (2 %w/v) but decreased permeability a... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5495108 Mon, 12 Dec 2011 05:00:00 +0100 5495108 http://www.medworm.com/index.php?rid=5495107&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280366 Planta MedDOI: 10.1055/s-0031-1280366AbstractShaoyao-Gancao-Tang (SGT) is a traditional Chinese prescription containing Radix Paeoniae alba and Radix Glycyrrhizae and is commonly used to relieve pains. Albiflorin and paeoniflorin are the main effective compounds of Radix Paeoniae alba, and the pharmacokinetic differences of the two compounds in rats after oral administration of SGT and single herb Paeony decoction were studied. At different time points (5, 10, 15, 20, 30, 45, 60, 90, 120, 180, 240, 360, and 540 min) after administration, plasma concentrations of albiflorin and paeoniflorin were determined using a simple and reliable UPLC method, and main pharmacokinetic parameters were evaluated. It was found that there were significant differences (p < 0.05 or p < 0.01) be... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5495107 Mon, 12 Dec 2011 05:00:00 +0100 5495107 http://www.medworm.com/index.php?rid=5495106&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280441 Planta MedDOI: 10.1055/s-0031-1280441AbstractA new pentanorlanostane, ganosineniol A (1), eight new lanostane triterpenoids, ganosinoside A (2), ganoderic acid Jc (3), ganoderic acid Jd (4), ganodermatetraol (5), ganolucidic acid γa (6), ganolucidate F (7), ganoderiol J (8), and methyl lucidenate Ha (9), and a new sesquiterpenoid, ganosinensine (10), together with eleven known triterpenoids (11–21), were isolated from the fruiting bodies of the fungus Ganoderma sinense. Chemical structures were determined based on spectroscopic evidence, including 1D, 2D NMR, and mass spectral data. Furthermore, all isolates were tested for cytotoxic activity and induction ability of hPXR-mediated CYP3A4 expression. Among them, ganoderic acid Jc (3) displayed selective inhibitory activity against HL-6... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5495106 Mon, 12 Dec 2011 05:00:00 +0100 5495106 http://www.medworm.com/index.php?rid=5487466&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280411 Planta MedDOI: 10.1055/s-0031-1280411AbstractSix new triterpenoids including four new secodammarane triterpenoid glycosides (1–4), an epoxydammarane triterpenoid glycoside (5), and a new secodammarane triterpenoid (6) were isolated from the ethanolic extract of the leaves of Cyclocarya paliurus. The structures of these compounds were elucidated by spectroscopic analysis methods. Compounds 1–6 were evaluated for their inhibitory activities against α-glucosidase, lipase, DPP-IV, and aldose reductase.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Planta Medica) Planta Medica journals http://www.medworm.com/rss/comments.php?id=5487466 Wed, 07 Dec 2011 05:00:00 +0100 5487466 http://www.medworm.com/index.php?rid=5469363&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280403 Planta MedDOI: 10.1055/s-0031-1280403AbstractTwo new C-15-acyl phragmalin limonoids, velutinalides A (2) and B (3), featuring a C-16/C-30 δ-lactone ring, and a new structurally related natural product, R310B8 (1), were isolated from the leaves of Chukrasia tabularis var. velutina. Their structures were elucidated on the basis of extensive spectroscopic data analyses and by comparison of their NMR data with those of related known compounds.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Planta Medica) Planta Medica journals http://www.medworm.com/rss/comments.php?id=5469363 Thu, 01 Dec 2011 05:00:00 +0100 5469363 http://www.medworm.com/index.php?rid=5469362&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280404 Planta MedDOI: 10.1055/s-0031-1280404AbstractDiabetes mellitus is the most common disease in the world. One therapeutic approach for treating diabetes is inhibition of α-amylase and α-glucosidase activities to reduce postprandial blood glucose levels. In vitro tests showed that several plant extracts from Brazilian cerrado species can inhibit the activity of α-amylase and α-glucosidase. The extracts of Eugenia dysenterica, Stryphnodendron adstringens, Pouteria caimito, Pouteria ramiflora, and Pouteria torta showed strong α-amylase and α-glucosidase inhibitory activity. Eugenia dysenterica, P. caimito, P. ramiflora, and P. torta aqueous extracts exerted the highest activity against α-amylase (IC50 values of 14.93, 13.6, 7.08, and 5.67 µg/mL, respectively) and α-glucosidase (IC50 ... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5469362 Thu, 01 Dec 2011 05:00:00 +0100 5469362 http://www.medworm.com/index.php?rid=5458332&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280373 Planta MedDOI: 10.1055/s-0031-1280373AbstractNine spirostanol saponins (1–9) and seven mixtures of 25R and 25S spirostanol saponin isomers (10–16) were obtained from the seeds of Trigonella foenum-graecum after enzymatic hydrolysis of the furostanol saponin fraction by β-glucosidase. Their structures were determined by NMR and MS spectroscopy. Among them, 1-4, 6, 8, and 9 were new compounds and five, 11b, 12a, 13b, 14a, and 14b, were new structures observed from seven mixtures. In addition, the inhibitory effects of all saponins on rat platelet aggregation were evaluated.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Planta Medica) Planta Medica journals http://www.medworm.com/rss/comments.php?id=5458332 Tue, 29 Nov 2011 05:00:00 +0100 5458332 http://www.medworm.com/index.php?rid=5458331&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280377 Planta MedDOI: 10.1055/s-0031-1280377AbstractThe therapy of type-2 diabetes mellitus is one of the major challenges of our age. A possible strategy to prevent the progression of this disease is the inhibition of protein tyrosine phosphatase 1B (PTP1B), a major negative regulator in the insulin and leptin signalling pathway. Phellodendri amurensis cortex is a well-known Asian herbal drug traditionally used as antiphlogistic, antibacterial, and anti-inflammatory agent, and its efficacy against diabetes-related symptoms is reported as well. However, information regarding active principle(s) or the molecular mode of action was scarce. By bioguided isolation using an in vitro enzyme assay with human recombinant PTP1B, (9Z)-octadec-9-enoic acid (oleic acid) could be identified as a major PTP1B i... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5458331 Mon, 28 Nov 2011 05:00:00 +0100 5458331 http://www.medworm.com/index.php?rid=5441448&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280384 In this study, we set up a practical method for the concurrent analysis of decursin, DA, and decursinol in mouse plasma and tumor tissues by liquid–liquid extraction and HPLC-UV and applied the method to several animal experiments. Plasma or tumor homogenate was extracted directly with ethyl acetate. The extraction efficiency for decursin/DA (quantitated together) and decursinol was between 82–95 % in both mouse plasma and tumor homogenate. The lower limit of quantitation (LLOQ) was approximately 0.25 µg/mL for decursin/DA and 0.2 µg/mL for decursinol in mouse plasma. In a pilot pharmacokinetic study, male C57BL/6 mice were given a single dose of 4.8 mg decursin/DA mixture (∼ 240 mg/kg) per mouse either by oral gavage or intraperitoneal injection. Maximum plasma concent... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5441448 Thu, 24 Nov 2011 05:00:00 +0100 5441448 http://www.medworm.com/index.php?rid=5441450&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280383 Planta MedDOI: 10.1055/s-0031-1280383AbstractA phytochemical investigation of Abuta rufescens was performed to authenticate plant material reported previously and to assess the cytotoxicity of the alkaloids obtained from the plant. Three alkaloids which have not previously been reported from this species, two phenolic (subsessiline, an oxoaporphine, and telitoxine, an azafluoranthene) and one non-phenolic (isoimerubrine, a tropoloisoquinoline), were isolated and identified. These alkaloids, along with others previously isolated from this and another Abuta species (grandirubrine, a tropoloisoquinoline), were evaluated for cytotoxic activity against several human cancer cell lines (HCT-116 colon adenocarcinoma, ACHN renal carcinoma, and A549 lung carcinoma). The tropoloisoquinoline alkaloids... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5441450 Tue, 22 Nov 2011 05:00:00 +0100 5441450 http://www.medworm.com/index.php?rid=5441449&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280345 Planta Med 2011; 77: 1869-1869DOI: 10.1055/s-0031-1280345© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Full text (Source: Planta Medica) Planta Medica journals http://www.medworm.com/rss/comments.php?id=5441449 Tue, 22 Nov 2011 05:00:00 +0100 5441449 http://www.medworm.com/index.php?rid=5441447&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280371 Planta MedDOI: 10.1055/s-0031-1280371AbstractIn continuation of ongoing studies on the potential of natural products as antiprotozoal leads or drugs, it was found that the CH2Cl2 extract obtained from the flowering aerial parts of Inula montbretiana DC. (Asteraceae, tribe Inuleae) displays antiprotozoal activity, especially against Trypanosoma brucei rhodesiense (IC50: 3.38 µg/mL). Isolation of the possible active constituents led to the identification of six sesquiterpene lactones, all esters of 9β-hydroxyparthenolide. Two isolates, namely, 9β-(3′,4′-epoxy-3′-methylpentanoyloxy)-parthenolide and 9β-(3′-oxo-2′-methylbutanoyloxy)-parthenolide, represented diastereomeric mixtures differing only in the configuration within the acyl moieties. According to in vitro test results,... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5441447 Tue, 22 Nov 2011 05:00:00 +0100 5441447 http://www.medworm.com/index.php?rid=5441446&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280385 Planta MedDOI: 10.1055/s-0031-1280385AbstractMost cosmetic and therapeutic applications of Clostridium botulinum neurotoxin (BoNT) are related to muscle paralysis caused by the blocking of neurotransmitter release at the neuromuscular junction. BoNT specifically cleaves SNARE proteins at the nerve terminal and impairs neuroexocytosis. Recently, we have shown that several polyphenols inhibit neurotransmitter release from neuronal PC12 cells by interfering with SNARE complex formation. Based on our previous result, we report here that myricetin, delphinidin, and cyanidin indeed paralyze muscle by inhibiting acetylcholine release at the neuromuscular junction. While the effect of myricetin on muscle paralysis was modest compared to BoNT/A, myricetin exhibited a shorter response time than BoNT... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5441446 Tue, 22 Nov 2011 05:00:00 +0100 5441446 http://www.medworm.com/index.php?rid=5432107&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280367 This study evaluated the in vitro permeability of the four major S. tortuosum alkaloids (i.e., mesembrine, mesembrenone, mesembrenol, and mesembranol) across porcine intestinal, sublingual, and buccal tissues in their pure form and in the form of three different crude plant extracts, namely water, methanol, and an acid-base alkaloid-enriched extract. The permeability of mesembrine across intestinal tissue was higher than that of the highly permeable reference compound caffeine (which served as a positive control for membrane permeability) both in its pure form, as well as in the form of crude extracts. The intestinal permeability of mesembranol was similar to that of caffeine, while those of mesembrenol and mesembrenone were lower than that of caffeine, but much higher than that of the poo... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5432107 Mon, 21 Nov 2011 05:00:00 +0100 5432107 http://www.medworm.com/index.php?rid=5422540&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280356 Planta MedDOI: 10.1055/s-0031-1280356AbstractFo Shou San (FSS) is an ancient herbal decoction composed of Angelicae Sinensis Radix (ASR; Danggui) and Chuanxiong Rhizoma (CR; Chuanxiong) in a ratio of 3 : 2. FSS is mainly prescribed for patients having a deficiency of blood supply, and it indeed has been shown to stimulate the production of erythropoietin (EPO) in cultured cells. In order to reveal the mechanism of this FSS-induced EPO gene expression, the upstream regulatory cascade, via hypoxia-induced signaling, was revealed here in cultured hepatocellular carcinoma cell line Hep3B. The induction of EPO gene expression, triggered by FSS, was revealed in cultured hepatocytes by: (i) the increase of EPO mRNA; and (ii) the activation of the hypoxia response element (HRE), an upstream re... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5422540 Thu, 17 Nov 2011 05:00:00 +0100 5422540 http://www.medworm.com/index.php?rid=5422539&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280372 Planta MedDOI: 10.1055/s-0031-1280372AbstractPlatycodin D (PD), a major component isolated from the root of Platycodon grandiflorum, is widely used in traditional Chinese medicine. A sensitive rapid analytical method was established and validated to determine the PD in rat plasma. This method was further applied to assess the pharmacokinetics of PD in rats following administration of a single dose. Liquid chromatography tandem mass spectrometry (LC/MS/MS) in multiple reaction monitoring mode (MRM) was used in the method, and tubeimoside I was used as the internal standard (IS). A simple protein precipitation based on methanol (MeOH) was employed. The combination of a simple sample cleanup and short chromatographic running time (4 min) increased the throughput of the method substantially.... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5422539 Thu, 17 Nov 2011 05:00:00 +0100 5422539 http://www.medworm.com/index.php?rid=5422538&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280359 This study would then substitute a dose-escalating trial, which in general is used to find the appropriate dose for clinical studies. The phase IIA clinical trial was carried out according to the WHO 2003 14-day test, and the results revealed that all eleven patients were completely cleared of parasitemia and fever on days 3, 7, and 14 except for one patient, who experienced a recurrence of parasitemia at days 7 until 14. Besides this adequate clinical and parasitological response (ACPR), this trial also demonstrated that PR 259 CT1 was well tolerated with only mild and self-resolving adverse effects including fatigue and headache, which were in accordance with those found in the phase I clinical trial. Moreover, all symptoms progressively disappeared, and no symptoms were observed on day ... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5422538 Thu, 17 Nov 2011 05:00:00 +0100 5422538 http://www.medworm.com/index.php?rid=5409047&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280347 Planta MedDOI: 10.1055/s-0031-1280347AbstractTwo new lactones, 1 and 2, together with five known compounds, 3–7, were isolated from the marine mangrove fungus Xylaria sp. BL321. Their structures were determined by comprehensive analysis of their MS and NMR spectroscopic data. The absolute configurations of 1 and 2 were established on the basis of electronic circular dichroism calculations. It was found that the exocyclic double bond of 1 rearranged into a cyclic double bond to form a new crystal compound (1a) in diluted NaOH solution. Compound 3 was isolated for the first time as a natural product; its absolute configuration was determined by single-crystal X-ray crystallography. Compounds 4–7 displayed cytotoxicity against human breast cancer cell lines MCF-7 and MDA-MB-435, while com... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5409047 Mon, 14 Nov 2011 05:00:00 +0100 5409047 http://www.medworm.com/index.php?rid=5409046&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280317 Planta MedDOI: 10.1055/s-0031-1280317AbstractHot flushes are due to the lack of estrogens and are the most characteristic climacteric complaints. Hormone replacement therapy was the standard treatment but now its use is limited because of side effects. Need therefore arises to search for non-estrogenic alternatives. The molting hormone 20-beta-hydroxyecdysone (Ecd) is produced by several plants including spinach and has no estrogenic or androgenic properties but enhances GABAergic effects in neurons. Since GABAergic compounds can ameliorate hot flushes, we investigated the effects of Ecd on subcutaneous body temperature of intact and ovariectomized (ovx) rats. The subcutaneous body temperature was recorded at 5-min intervals over a period of 3 hours. Rats were then ovx, and skin temperatur... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5409046 Mon, 14 Nov 2011 05:00:00 +0100 5409046 http://www.medworm.com/index.php?rid=5409045&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280338 Planta MedDOI: 10.1055/s-0031-1280338AbstractA new 2-arylbenzofuran derivative, (+)-dimethylsmoracin O (1), and three new Diels-Alder type adducts, mesozygins A–C (2–4), in addition to eight known compounds, artonin I (5), chalcomaracin (6), norartocarpetin (7), moracin L (8), mulberrofuran F (9), moracin M (10), moracin C (11), and morachalcone A (12), were isolated from the leaves of Morus mesozygia Stapf. Structures were elucidated by spectroscopic data analyses. Compounds 2–7 displayed a potent phosphodiesterase I inhibitory activity.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Planta Medica) Planta Medica journals http://www.medworm.com/rss/comments.php?id=5409045 Mon, 14 Nov 2011 05:00:00 +0100 5409045 http://www.medworm.com/index.php?rid=5409044&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280346 Planta MedDOI: 10.1055/s-0031-1280346AbstractTwo Chinese herb-derived small molecule telomerase activators, astragaloside IV (AG-IV) and cycloastragenol (CAG), have recently been shown to improve the proliferative response of CD8+ T lymphocytes from HIV-infected patients by upregulating telomerase activity. Here, we examined the signaling mechanism of AG-IV and CAG. Telomerase activity in human embryonic kidney HEK293 fibroblasts was increased upon treatment with increasing concentrations of AG-IV or CAG. Both compounds induced the phosphorylation of extracellular signal-regulated protein kinase (ERK) in a time- and dose-dependent manner in HEK293 cells and HEK-neo keratinocytes. AG-IV and CAG also stimulated ERK phosphorylation in other cell lines of lung, brain, mammary, endothelial, and... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5409044 Mon, 14 Nov 2011 05:00:00 +0100 5409044 http://www.medworm.com/index.php?rid=5409043&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280316 Planta MedDOI: 10.1055/s-0031-1280316AbstractAnti-staphylococcal activity of Chilean medicinal plants traditionally used by the Huilliche people for wound healing therapy was evaluated against nine Staphylococcus aureus strains. Three extracts of 26 plant samples (20 species) were evaluated by agar overlay bioautography and MIC determination. Total phenolics and tannins were determined, and the antibacterial contribution of the latter was evaluated. The diffusion assay showed that 17 species were active against susceptible S. aureus and that 15 species were active against resistant S. aureus. Removal of tannins from extracts rendered only six species active. MIC-determination showed that 20 extracts had antibacterial activity on all eight strains, and the most potent MIC value was 64 µg... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5409043 Mon, 14 Nov 2011 05:00:00 +0100 5409043 http://www.medworm.com/index.php?rid=5387755&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280319 Planta MedDOI: 10.1055/s-0031-1280319AbstractMedicinal plants have been used as a source of remedies since ancient times in Egypt. The present study was designed to investigate the antibacterial activity and the cytotoxicity of the organic extracts from 16 selected medicinal plants of Egypt. The study was also extended to the isolation of the antiproliferative compound jaeschkeanadiol p-hydroxybenzoate (FH-25) from Ferula hermonis. The microbroth dilution was used to determine the minimal inhibitory concentration (MIC) of the samples against twelve bacterial strains belonging to four species, Providencia stuartii, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Escherichia coli, while a resazurin assay was used to assess the cytotoxicity of the extracts on the human pancreatic cancer ce... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5387755 Fri, 04 Nov 2011 04:00:00 +0100 5387755 http://www.medworm.com/index.php?rid=5360806&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280320 Planta MedDOI: 10.1055/s-0031-1280320AbstractFour new triterpene saponins, ginsenosides Rh14-Rh17 (1–4), along with two known compounds, 20(S)-ginsenoside Rg2 and dammar-(E)-20(22),24-diene-3β,6α,12β-triol, were isolated from the stems and leaves of Panax ginseng. The structures of the new compounds were elucidated as 3β,6α,12β,24ξ-tetrahydroxy-dammar-(E)-20(22),25-diene 6-O-α-L-rhamnopyranosyl-(1 → 2)-β-D-glucopyranoside (1), 3β,12β,24ξ-trihydroxy-dammar-(E)-20(22),25-diene 3-O-β-D-glucopyranosyl-(1 → 2)-β-D-glucopyranoside (2), 3β,6α,12β-trihydroxy-dammar-(E)-20(22),24-diene 3-O-β-D-glucopyranoside (3), and 3-oxo-6α,12β,20(S)-trihydroxy-dammar-24-ene 6-O-α-L-rhamnopyranosyl-(1 → 2)-β-D-glucopyranoside (4) by means of extensive spectroscopic and c... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5360806 Thu, 27 Oct 2011 04:00:00 +0100 5360806 http://www.medworm.com/index.php?rid=5360805&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280315 Planta MedDOI: 10.1055/s-0031-1280315AbstractFour β-lactone-γ-lactam proteasome inhibitors of natural origin were tested for their trypanocidal activities in vitro using culture-adapted bloodstream forms of Trypanosoma brucei. All four compounds displayed activities in the nanomolar range. The most trypanocidal compounds with 50 % growth inhibition (GI50) values of around 3 nM were the bromine and iodine analogues of salinosporamide A, a potent proteasome inhibitor produced by the marine actinomycete Salinispora tropica. In general, trypanosomes were more susceptible to the compounds than were human HL-60 cells. The data support the potential of β-lactone-γ-lactam proteasome inhibitors for rational anti-trypanosomal drug development.[...]© Georg Thieme Verlag KG Stuttgart · New Y... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5360805 Thu, 27 Oct 2011 04:00:00 +0100 5360805 http://www.medworm.com/index.php?rid=5348016&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280311 Planta MedDOI: 10.1055/s-0031-1280311AbstractSix new lignans, 1–6, along with six known compounds were obtained from the flower buds of Magnolia liliflora Desr. The new lignans were elucidated as (1S*,2R*,5S*,6S*)-2-(3,5-dimethoxyphenyl)-6-(3,4-methylenedioxyphenyl)-3,7-dioxabicyclo[3.3.0]octane (1), (1R*,2R*,5R*,6S*)-2-(3,5-dimethoxyphenyl)-6-(3,4-methylenedioxyphenyl)-3,7-dioxabicyclo[3.3.0]octane (2), (1R*, 2R*,5R*,6S*)-2,6-bis (3,5-dimethoxyphenyl)-3,7-dioxabicyclo[3.3.0]octane (3), (1R*,2S*,5R*,6R*)-2-(3,4-methylenedioxyphenyl)-6-(3,5-dimethoxyphenyl)-3,7-dioxabicyclo[3.3.0]octane (4), (7′S*,8R*,8′R*)-3,5′-dimethoxy-3′,4,9′-trihydroxy-7′, 9-epoxy-8,8′-lignan (5), and (7′R*,8′S*)-3,3′,4,5′-tetramethoxy-7-en-7′,9-epoxy-8,8′-lignan (6), by the analysis of ... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5348016 Mon, 24 Oct 2011 04:00:00 +0100 5348016 http://www.medworm.com/index.php?rid=5315000&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280294 Planta MedDOI: 10.1055/s-0031-1280294AbstractA novel trinorsesquiterpene (1), three new (2–4), and 10 known sesquiterpenes were isolated from the roots of Inula racemosa Hook. f. The structures and absolute configurations of the new sesquiterpenes were elucidated by extensive spectroscopic and computational methods. All compounds were evaluated for their inhibition of LPS-induced nitric oxide production in RAW264.7 macrophages, and the results indicated that compounds 9, 12, and 13 moderately inhibited nitric oxide production with IC50 values of 7.39 ± 0.36, 6.35 ± 0.26, and 5.39 ± 0.18 µM, respectively.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Planta Medica) Planta Medica journals http://www.medworm.com/rss/comments.php?id=5315000 Fri, 14 Oct 2011 04:00:00 +0100 5315000 http://www.medworm.com/index.php?rid=5314999&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280293 Planta MedDOI: 10.1055/s-0031-1280293AbstractHigh-throughput natural product research produced a suite of anticancer hits among several species of the Orchidaceae family (Oncidium microchilum, O. isthmi, and Myrmecophila humboldtii). A commercial Oncidium sp. was also examined as a convenient source of additional material. Isolation and structure elucidation led to the identification of fifteen stilbenoids including a new phenanthraquinone and two new dihydrostilbenes. NMR data for structure elucidation and dereplication were acquired utilizing a Bruker BioSpin TCI 1.7-mm MicroCryoProbe or a 5-µL CapNMR capillary microcoil. Several compounds inhibited proliferation of NCI-H460 and M14 cancer cell lines. All compounds were also examined for their ability to induce apoptosis. Apoptosis indu... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5314999 Fri, 14 Oct 2011 04:00:00 +0100 5314999 http://www.medworm.com/index.php?rid=5314998&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280268 Planta MedDOI: 10.1055/s-0031-1280268AbstractIn the present study, the anti-diabetic effects of a traditional Chinese medicinal formula extract, TongGuanWan, were investigated in type 2 diabetic animals. It was orally administered to C57BL/KsJ-db/db mice once a day for 4 weeks at the doses of 62, 125, and 250 mg/kg body weight. TongGuanWan significantly lowered the blood glucose and glycosylated haemoglobin levels as well as improved the glucose tolerance in db/db mice. The serum triglyceride levels in the db/db mice were significantly decreased, whereas the high-density lipoprotein cholesterol levels were significantly increased, after treatment with this herbal formula. TongGuanWan also markedly decreased the animals' body weights compared to those of the control db/db group but did no... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5314998 Fri, 14 Oct 2011 04:00:00 +0100 5314998 http://www.medworm.com/index.php?rid=5314997&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280289 Planta MedDOI: 10.1055/s-0031-1280289AbstractTwo new 2-arylbenzofuran neolignans (1, 2) and a new benzophenanthridine alkaloid (3), together with six known benzophenanthridine alkaloids, namely, decarine (4), norchelerythrine (5), dihydrochelerythrine (6), 6-acetonyldihydrochelerythrine (7), tridecanonchelerythrine (8), and 6-acetonyldihydronitidine (9), have been isolated from the MeOH extract of the roots of Zanthoxylum capense. Their structures were elucidated by means of spectroscopic techniques including 2D NMR experiments. All the isolated compounds were evaluated for their in vitro antibacterial activity against gram-positive and gram-negative bacteria. Some compounds showed significant inhibitory activity against Staphylococcus aureus ATCC 6538 with MIC values ranging from 12.5 t... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5314997 Fri, 14 Oct 2011 04:00:00 +0100 5314997 http://www.medworm.com/index.php?rid=5314996&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280292 Planta MedDOI: 10.1055/s-0031-1280292AbstractTwenty-six microbiologically inactive (MIC > 512 µg/mL) convolvulaceous resin glycosides (1–26) were tested for resistance modulatory activity in vitro against Escherichia coli Rosetta-gami and two nosocomial pathogens, Salmonella typhi and Shigella flexneri. These compounds exerted a potentiation effect of the clinically useful antibiotics tetracycline, kanamycin, and chloramphenicol against the tested gram-negative bacteria by increasing antibiotic susceptibility up to 32-fold at concentrations of 25 µg/mL. Therefore, the oligosaccharides from the morning glory family (Convolvulaceae) represent metabolites that reverse microbial resistance mechanisms, favoring an increase in the strength and effectiveness of current antibiotics th... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5314996 Fri, 14 Oct 2011 04:00:00 +0100 5314996 http://www.medworm.com/index.php?rid=5304865&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280263 Planta MedDOI: 10.1055/s-0031-1280263AbstractThe present paper describes the study of the phytochemical properties and anti-HIV activity of the phenolic isolates of the plateau medicinal plant Daphne acutiloba Rehd. (Thymelaeceae). Two new lignans named daphnenin (1) and daphnetone (2), along with 11 known ones, were isolated, and their structures were elucidated by 1D and 2D NMR spectroscopy as well as HR‐ESI‐MS. In the anti-HIV activity study, daphnenin (1) and caffeic acid n-octadecyl ester (13) showed definite anti-HIV activity with EC50 values of 0.39 and 0.16 µg/mL, respectively.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Planta Medica) Planta Medica journals http://www.medworm.com/rss/comments.php?id=5304865 Tue, 11 Oct 2011 04:00:00 +0100 5304865 http://www.medworm.com/index.php?rid=5297346&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280266 Planta MedDOI: 10.1055/s-0031-1280266AbstractThree new hydroquinone terpenoids with benzogeijerene skeletons, euchroquinols A–C (1–3), and a new monoterpenylbenzenoid, 9,17-epoxyarnebinol (4), along with five known compounds were isolated from the stem bark of Arnebia euchroma. Shikonin (6) exhibited potent anti-HCV activity with a selective index of 43.56, and compounds 1, 6, and des-O-methyllasiodiplodin (7) showed anti-Staphylococcus aureus activity with MICs of 0.5, 0.125, and 0.125 mg/mL, respectively.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Planta Medica) Planta Medica journals http://www.medworm.com/rss/comments.php?id=5297346 Fri, 07 Oct 2011 04:00:00 +0100 5297346 http://www.medworm.com/index.php?rid=5297345&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280264 Planta MedDOI: 10.1055/s-0031-1280264AbstractTwo new sesquiterpenes, (E)-(2S,3S,6R)-atlantone-2,3-diol (1) and (E)-(2S,3S,6S)-atlantone-2,3,6-triol (2), along with two known sesquiterpenes, atlantolone (3) and (E)-α-atlantone (4), were isolated from Cedrus deodara Loud. The structures of the new compounds were elucidated on the basis of UV, IR, NMR, HR‐ESI-QTOF‐MS, and EI mass spectral studies. The n-hexane and chloroform extracts of sawdust and compounds 3 and 4 from the plant exhibited antifungal activity against Aspergillus flavus, A. niger, A. ochracoeus, A. parasiticus, and A. sydowii. A weak activity was also recorded against A. parasiticus and A. sydowii for compound 1, while Trichophyton rubrum was inhibited by compound 2 and the extracts.[...]© Georg Thieme Verlag KG Stu... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5297345 Thu, 06 Oct 2011 04:00:00 +0100 5297345 http://www.medworm.com/index.php?rid=5297344&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280179 Planta MedDOI: 10.1055/s-0031-1280179AbstractThe dichloromethane/methanol (1 : 1) extracts of the roots of Pentas longiflora and Pentas lanceolata showed low micromolar (IC50 = 0.9–3 µg/mL) in vitro antiplasmodial activity against chloroquine-resistant (W2) and chloroquine-sensitive (D6) strains of Plasmodium falciparum. Chromatographic separation of the extract of Pentas longiflora led to the isolation of the pyranonaphthoquinones pentalongin (1) and psychorubrin (2) with IC50 values below 1 µg/mL and the naphthalene derivative mollugin (3), which showed marginal activity. Similar treatment of Pentas lanceolata led to the isolation of eight anthraquinones (4–11, IC50 = 5–31 µg/mL) of which one is new (5,6-dihydroxydamnacanthol, 11), while three – nordamnacanth... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5297344 Thu, 06 Oct 2011 04:00:00 +0100 5297344 http://www.medworm.com/index.php?rid=5297343&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280265 Planta MedDOI: 10.1055/s-0031-1280265AbstractActivity-directed isolation of the ethyl acetate fraction from the roots of Rubia cordifolia resulted in the identification of a new anthraquinone, 1,3,6-trihydroxy-2-hydroxymethyl-9,10-anthraquinone-3-O-α-L-rhamnopyranosyl-(1 → 2)-β-D-(6′-O-acetyl)-glucopyranoside (1), two new dihydronaphtoquinones, 1,4-dihydroxy-2-carbomethoxy-3-prenylnaphthalene-1-O-β-D-glucopyranoside (2) and mollugin-1-O-β-D-glucopyranoside (3), and a new monoterpenoid, 3R,3aS,4R,6aR-3,4,6-tris(hydroxymethyl)-3,3a,4,6a-tetrahydro-2H-cyclopenta[b]furan-2-one (4), together with nine known compounds (5–13). The structures of these compounds were elucidated on the basis of spectroscopic evidence. In addition, their DNA topoisomerases I and II inhibitory activity a... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5297343 Thu, 06 Oct 2011 04:00:00 +0100 5297343 http://www.medworm.com/index.php?rid=5297342&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280269 Planta MedDOI: 10.1055/s-0031-1280269AbstractCortex Moutan (root bark of Paeonia suffruticosa Andrew) and Radix Salviae miltiorrhizae (root and rhizome of Salvia miltiorrhiza Bunge) are two herbs widely used in traditional Chinese medicine (TCM) to treat cerebrovascular and cardiovascular diseases. In clinical practice, these two herbs are prescribed together. Studies on the pharmacokinetic interaction between the active constituents of these two herbs (paeonol and danshensu, respectively) can provide substantial foundation for understanding its mechanism and empirical evidence to support the clinical practice. A simple and sensitive high-performance liquid chromatographic (HPLC) method coupled with ultraviolet detector was developed for determination of paeonol in plasma and different tis... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5297342 Thu, 06 Oct 2011 04:00:00 +0100 5297342 http://www.medworm.com/index.php?rid=5274434&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280218 Planta MedDOI: 10.1055/s-0031-1280218AbstractEight new 19-oxygenated ent-kaurane diterpenoids (1–8) were isolated from the aerial parts of Isodon pharicus. Their structures were determined by means of extensive spectroscopic techniques including interpretation of 1D and 2D NMR spectra. Selected compounds were evaluated for their cytotoxicity against NB4, A549, PC-3, MCF-7, and SH-SY5Y cell lines.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Planta Medica) Planta Medica journals http://www.medworm.com/rss/comments.php?id=5274434 Fri, 30 Sep 2011 04:00:00 +0100 5274434 http://www.medworm.com/index.php?rid=5274435&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280251 Planta MedDOI: 10.1055/s-0031-1280251AbstractTwo new polyketides, arthropsadiol C (1) and massarilactone H (2), together with six known derivatives (3–8) were isolated from the culture broth of the marine-derived fungus Phoma herbarum. Their structures were elucidated on the basis of spectroscopic methods, including 2D NMR techniques. Compounds 2, 4, 5, and 8 showed moderate neuraminidase inhibitory activity with IC50 values ranging from 4.15 to 9.16 µM.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Planta Medica) Planta Medica journals http://www.medworm.com/rss/comments.php?id=5274435 Tue, 27 Sep 2011 04:00:00 +0100 5274435 http://www.medworm.com/index.php?rid=5274433&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280256 Planta MedDOI: 10.1055/s-0031-1280256AbstractThe methanolic extract of Ammannia multiflora (Lythraceae) showed significant bioenhancing activity with the antibiotic nalidixic acid. Bioassay-guided fractionation of MeOH extract resulted in the isolation of a novel compound, 2,5-bis-(3,3′-hydroxyaryl)tetrahydrofuran, named as ammaniol (5), along with 9 other known compounds (1–4, 6–10). Furthermore, compound 4-hydroxy-α-tetralone (1) was converted into five semisynthetic acyl derivatives, 1A–1E, which were evaluated along with compounds 1, 5, 6, 9, and 10 for their bioenhancing activity in combination with nalidixic acid against the two strains, CA8000 and DH5α, of Escherichia coli. The results showed that the methanolic extract of A. multiflora and compounds 1 and 9 possessed sig... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5274433 Tue, 27 Sep 2011 04:00:00 +0100 5274433 http://www.medworm.com/index.php?rid=5274432&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280163 Planta MedDOI: 10.1055/s-0031-1280163AbstractThree new clerodane diterpene glycosides, tinospinosides A (1), B (2), and C (3) were isolated from the roots of Tinospora sagittata (Oliv.) Gagnep. Their structures were determined to be (2S,4aR,6aR,9R,10aS,10bS)-2-(3-furanyl)-9-(β-D-glucopyranosyloxy)-1,4,4a,5,6,6a,9,10,10a,10b-decahydro-6a,10b-dimethyl-4-oxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester (1), (2S,4aS,6aR,9R,10aR,10bS)-2-(3-furanyl)-9-(β-D-glucopyranosyloxy)-1,4,4a,5,6,6a,9,10,10a,10b-decahydro-4a-hydroxyl-6a,10b-dimethyl-4-oxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester (2) and (2S,4aR,6aR,9R,10aR,10bS)-2-(3-furanyl)-9-(β-D-glucopyranosyloxy)-1,4,4a,5,6,6a,9,10,10a,10b-decahydro-4a-hydroxyl-6a,10b-dimethyl-4-oxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid met... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5274432 Tue, 27 Sep 2011 04:00:00 +0100 5274432 http://www.medworm.com/index.php?rid=5226553&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280228 We report for the first time significant changes in these parameters by GEN and E2. Changes in the size of cardiomyocytes were observed by GEN and E2. In line with these observations, cardiac expression of insulin-like growth factor 1 (Igf1) was significantly induced by both GEN and E2. Thus, we speculate that endocrine active compounds, like the isoflavone GEN, which is used as a food additive or as a drug for the treatment of menopausal symptoms, may directly affect heart function.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Planta Medica) Planta Medica journals http://www.medworm.com/rss/comments.php?id=5226553 Fri, 16 Sep 2011 04:00:00 +0100 5226553 http://www.medworm.com/index.php?rid=5226552&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280216 This study may provide some useful information for the chemotaxonomy for the plant Cyperus rotundus.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Planta Medica) Planta Medica journals http://www.medworm.com/rss/comments.php?id=5226552 Fri, 16 Sep 2011 04:00:00 +0100 5226552 http://www.medworm.com/index.php?rid=5226551&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280217 This study aimed to investigate whether capsiate is able to produce beneficial effects on gastric mucosa and whether the protective effects of capsipate occur through a mechanism involving the activation of TRPV1 and CGRP release. A rat model of gastric mucosal injury was established by the oral administration of acidified ethanol. Gastric tissues were collected for analysis of the gastric ulcer index, cellular apoptosis, activities of caspase-3, catalase and superoxide dismutase (SOD), and levels of CGRP, TNF-α, and malondialdehyde (MDA). Our results show that the acute administration of ethanol significantly increased the gastric ulcer index concomitantly with an increase in cellular apoptosis, caspase-3 activity, and TNF-α and MDA levels, as well as a decrease in the activities of cat... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5226551 Fri, 16 Sep 2011 04:00:00 +0100 5226551 http://www.medworm.com/index.php?rid=5226550&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280219 In this study, the antihyperlipidemic effect of the salt form (sodium succinate) of ZYM-201 was examined using streptozotocin (STZ)-treated hyperglycemic rats. Oral administration of ZYM-201 sodium succinate (3 to 10 mg/kg) resulted in recovery of the increased serum levels of triglyceride (TG) and total cholesterol (TC) back to normal levels. Elevated levels of serum lipoproteins, such as high-density lipoprotein (HDL), low-density lipoprotein (LDL), and very low-density lipoprotein (VLDL), were also significantly restored by this compound without altering 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase activity. Finally, ZYM-201 sodium succinate displayed antioxidative properties, including suppression of lipid peroxide and hydroxyl radical generation and upregulation of superoxide dism... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5226550 Fri, 16 Sep 2011 04:00:00 +0100 5226550 http://www.medworm.com/index.php?rid=5226549&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280127 Planta MedDOI: 10.1055/s-0031-1280127AbstractA bioassay-guided fractionation and chemical investigation of the trunk of Berberis koreana led to the isolation and identification of three new triterpenoids, 2α,3α,19α-trihydroxy-urs-12-en-24-formyl-28-oic acid (1), 2α,3β,21α-trihydroxy-urs-12-en-28-oic acid (2), and 3β-acetyloxy-1-oxo-olean-12-en-28-oic acid (3), along with seven known triterpenoids (4–10). The structures of these new compounds were determined through spectral analysis, including extensive 2D-NMR data. The new compounds 1–3 showed significant cytotoxicity against the A549, SK-OV-3, SK-MEL-2, and HCT-15 human tumor cell lines with IC50 values ranging from 7.17 to 48.73 µM.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of con... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5226549 Fri, 16 Sep 2011 04:00:00 +0100 5226549 http://www.medworm.com/index.php?rid=5226548&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280199 Planta MedDOI: 10.1055/s-0031-1280199AbstractThe control of blood glucose levels is critical in the treatment of diabetes mellitus. α-Glucosidase inhibitors are of great importance in reducing hyperglycemia, and plants have provided many of these agents. The present study aimed at investigating the effect of two stilbenes, lonchocarpene and 3,5-dimethoxy-4′-O-prenyl-trans-stilbene (DPS), isolated from the Amazonian plant Deguelia rufescens var. urucu, on α-glucosidase activity and on mice postprandial hyperglycemia. Lonchocarpene and DPS inhibited α-glucosidase in vitro, with pIC50 values of 5.68 ± 0.12 and 5.73 ± 0.08, respectively. In addition, when given orally, DPS produced a significant reduction of hyperglycemia induced by an oral tolerance test, while lonchocarpene di... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5226548 Fri, 16 Sep 2011 04:00:00 +0100 5226548 http://www.medworm.com/index.php?rid=5226547&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280227 Planta MedDOI: 10.1055/s-0031-1280227AbstractThree new β-indoloquinazoline alkaloids, orirenierine A (1), B (2) and C (4), together with eleven known compounds were isolated from the methanol extract of the stems of Oricia renieri. The structures of all compounds were determined by comprehensive analyses of their spectroscopic data and comparison with literature information. The alkaloids 9–11 were isolated for the first time from this genus. All compounds were tested for their activity against bacteria, fungi, and plant pathogen oomycetes using the paper disk agar diffusion assay. The agar diffusion test gave only low antimicrobial activities, corresponding to MICs > 1 mg/mL. However, compounds 1–4 and 11 exhibited a strong suppressive effect on phagocytosis response upon acti... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5226547 Fri, 16 Sep 2011 04:00:00 +0100 5226547 http://www.medworm.com/index.php?rid=5184569&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280145 Planta Med 2011; 77: 1567-1567DOI: 10.1055/s-0031-1280145© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  FREE Full text (Source: Planta Medica) Planta Medica journals http://www.medworm.com/rss/comments.php?id=5184569 Wed, 31 Aug 2011 23:00:00 +0100 5184569 http://www.medworm.com/index.php?rid=5162588&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1271164 Planta MedDOI: 10.1055/s-0030-1271164AbstractOne new triterpene, kudinchalactone A (1), and four new triterpenoid saponins, ilekudinchosides A−D (2–5), were isolated from the leaves of Ilex kudincha C. J. Tseng along with eight known triterpenoids. These new compounds were elucidated by spectroscopic methods including 1D and 2D NMR, HR‐TOF‐MS, and CD spectra. Compounds 2, 3, 12, and 13 showed antibacterial activities against Staphylococcus aureus (SA) and methicillin-resistant Staphylococcus aureus (MRSA).[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Planta Medica) Planta Medica journals http://www.medworm.com/rss/comments.php?id=5162588 Wed, 24 Aug 2011 23:00:00 +0100 5162588 http://www.medworm.com/index.php?rid=5162587&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280128 Planta MedDOI: 10.1055/s-0031-1280128AbstractFour new flavone C-glycosides, luteolin 6-C-α-L-arabinopyranosyl-7-O-β-D-glucopyranoside (1), apigenin 6-C-β-D-galactopyranosiduronic acid (1 → 2)-α-L-arabinopyranoside (2), luteolin 6-C-β-D-galactopyranosiduronic acid (1 → 2)-α-L-arabinopyranoside (3), and luteolin 6-C-β-D-glucopyranosiduronic acid (1 → 2)-α-L-arabinofuranoside (4), along with three known ones, were isolated from the leaves of Lophatherum gracile. The structures of the new compounds were elucidated by extensive spectroscopic methods as well as acid hydrolysis. All the flavone glycosides isolated from this plant were screened for their in vitro antiviral activity against respiratory syn... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5162587 Wed, 24 Aug 2011 23:00:00 +0100 5162587 http://www.medworm.com/index.php?rid=5162586&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1279990 In conclusion, we have demonstrated an ethanol-extractable myelostimulatory activity in Echinacea aerial parts that, when obtained from commercial herbal supplements, may be antagonized by medium-chain fatty acids presumably derived from a non-plant additive.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Planta Medica) Planta Medica journals http://www.medworm.com/rss/comments.php?id=5162586 Wed, 24 Aug 2011 23:00:00 +0100 5162586 http://www.medworm.com/index.php?rid=5162585&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1279996 Planta MedDOI: 10.1055/s-0031-1279996AbstractChios mastic gum, the resin obtained as an exudate from the trunk and branches of Pistacia lentiscus L var. chia, is used extensively as a constituent of herbal drugs or functional foods. The oral absorption of its major constituents still remains unclear. In the context of identifying the features of mastic gum that are responsible for either therapeutic effects or effects of nutritional value, a methodology based on high-performance liquid chromatography (HPLC) coupled to tandem mass spectrometry (MS/MS) was developed and applied for the quantification of mastic gum triterpenic acids, 24Z-isomasticadienonic acid (IMNA), and 24Z-isomasticadienolic acid (IMLA) in mouse plasma. The specific compounds were selected based on their biological activi... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5162585 Wed, 24 Aug 2011 23:00:00 +0100 5162585 http://www.medworm.com/index.php?rid=5162584&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280114 Planta MedDOI: 10.1055/s-0031-1280114AbstractTwo new xanthonolignoids, hypericorin A (1) and hypericorin B (2), along with five known new source compounds, a xanthonolignoid, kielcorin (3), 4-hydroxy-2,3-dimethoxyxanthone (4), 3,4,5-trihydroxyxanthone (5), 1,3-dihydroxy-5-methoxyxanthone (6) and 1,3,7-trihydroxyxanthone (7), were isolated from the stems (twigs) of Hypericum oblongifolium Wall. The structures of the new compounds were deduced on the basis of spectroscopic techniques (EI‐MS, HREI‐MS, 1H NMR, 13C NMR, HMQC, HMBC, and NOESY). We also report herein for the first time the single crystal X‐ray structure of compound 6. Compounds 1–7 were screened for their in vitro anti-inflammatory (respiratory burst) inhibiting activities using isolated human neutrophils;... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5162584 Wed, 24 Aug 2011 23:00:00 +0100 5162584 http://www.medworm.com/index.php?rid=5162583&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280124 Planta MedDOI: 10.1055/s-0031-1280124AbstractIn the course of our investigations on Strychnos usambarensis leaves in order to isolate isostrychnopentamine, the main alkaloid responsible for the antiplasmodial activity of the plant, a new tertiary indolic alkaloid has been isolated: 17-O-acetyl,10-hydroxycorynantheol 1. Its structure was determined by means of spectroscopic and spectrometric methods such as UV, IR, CD, NMR, and ESI‐MS. 17-O-acetyl,10-hydroxycorynantheol 1 is one of the most active monomeric indole alkaloids known to date showing an in vitro activity against Plasmodium falciparum close to 5 µM and a high selectivity.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Planta... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5162583 Wed, 24 Aug 2011 23:00:00 +0100 5162583 http://www.medworm.com/index.php?rid=5162589&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280209 Planta MedDOI: 10.1055/s-0031-1280209© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  FREE Full text (Source: Planta Medica) Planta Medica journals http://www.medworm.com/rss/comments.php?id=5162589 Mon, 22 Aug 2011 23:00:00 +0100 5162589 http://www.medworm.com/index.php?rid=5144355&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280117 Planta MedDOI: 10.1055/s-0031-1280117AbstractTo gain insights on the effects of color type, cultivation history, and growing site on the composition alterations of maca (Lepidium meyenii Walpers) hypocotyls, NMR profiling combined with chemometric analysis was applied to investigate the metabolite variability in different maca accessions. Maca hypocotyls with different colors (yellow, pink, violet, and lead-colored) cultivated at different geographic sites and different areas were examined for differences in metabolite expression. Differentiations of the maca accessions grown under the different cultivation conditions were determined by principle component analyses (PCAs) which were performed on the datasets derived from their 1H NMR spectra. A total of 16 metabolites were identified by NM... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5144355 Thu, 18 Aug 2011 23:00:00 +0100 5144355 http://www.medworm.com/index.php?rid=5144354&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280125 Planta MedDOI: 10.1055/s-0031-1280125AbstractThe stem with hooks of Uncaria rhynchophylla is a component herb of many traditional formulae for the treatment of neurodegenerative diseases. However, scientific evidence of the efficacy of Uncaria rhynchophylla in the treatment of Alzheimer's disease (AD) in animal models is lacking. Thus, in the present study, we investigated whether the 70 % aqueous ethanol extract of Uncaria rhynchophylla (EUR) could protect against D-galactose (D‐gal)-induced cognitive deficits in mice. Mice were given a subcutaneous injection of D‐gal (50 mg/kg) and orally administered EUR (100, 200, or 400 mg/kg) daily for 8 weeks. The effect of EUR on D‐gal-induced cognitive deficits was evaluated by measuring behavioral and neurochem... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5144354 Thu, 18 Aug 2011 23:00:00 +0100 5144354 http://www.medworm.com/index.php?rid=5144353&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280126 Planta MedDOI: 10.1055/s-0031-1280126AbstractTwelve isoquinoline alkaloids including two new nitro-containing tetrahydroprotoberberines, (−)-2,9-dihydroxyl-3,11-dimethoxy-1,10-dinitrotetrahydroprotoberberine (1) and (+)-4-nitroisoapocavidine (2), were isolated from the whole plant of Corydalis saxicola Bunting. The structures of the new compounds were established by spectroscopic analysis and chemical evidence. The inhibitory activity of these isolates against cholinesterase and canine parvovirus were evaluated. Compounds 1 and 1a, (+)-1-nitroapocavidine (5), berberine (8), palmatine (9), dehydrocavidine (10), and sanguinarine (11) showed potent inhibitory activity against acetylcholinesterase with IC50 values of less than 10 µM, while only compound 1 possessed weak activity a... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5144353 Thu, 18 Aug 2011 23:00:00 +0100 5144353 http://www.medworm.com/index.php?rid=5144352&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280129 Planta MedDOI: 10.1055/s-0031-1280129AbstractThe aim of this work was to investigate the effects of St. John's Wort (SJW) extract treatment on behavioral changes arising in streptozotocin (STZ)-diabetic rats. Plus-maze, activity cage, modified forced swimming, and active avoidance tests were performed for evaluating exploratory behaviors, spontaneous locomotor activities, depression levels, and learning parameters of animals, respectively. Obtained data exhibited a diabetes mellitus (DM)-induced increase in anxiety and depression levels, decrease in spontaneous locomotor activities, and impairment of learning parameters in rats even in the early stages of the disease. Daily insulin replacement (2 IU/kg/day) could not restore these impaired parameters completely, indicating the need ... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5144352 Thu, 18 Aug 2011 23:00:00 +0100 5144352 http://www.medworm.com/index.php?rid=5144351&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280118 Planta MedDOI: 10.1055/s-0031-1280118AbstractGuided by lipid-lowering assays, a new compound (1, 2-phenylethyl 2,6-dihydroxybenzoate) was isolated from the ethanolic extract of Geophila herbacea. The structure of 1 was determined unambiguously by spectral data interpretation and confirmed by X‐ray crystallographic analysis. Preliminary dose-dependency of 1 verified its lipid-lowering bioactivity in vitro. A facile chemical synthesis for 1 was performed to provide a practical approach for further studies on structure-activity relationship.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Planta Medica) Planta Medica journals http://www.medworm.com/rss/comments.php?id=5144351 Thu, 18 Aug 2011 23:00:00 +0100 5144351 http://www.medworm.com/index.php?rid=5144356&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280088 Planta MedDOI: 10.1055/s-0031-1280088AbstractTwo novel chalconoids, [3–3′′]bi-2-hydroxy-4,5,6-trimethoxydihydrochalcone (1) and 4,6-dimethoxy-2,5-quinodihydrochalcone (2), and twelve known compounds were isolated from the methanolic extract of Fissistigma latifolium (Dun.) Merr. The structures of all compounds were determined by spectroscopic methods. Of these, compounds 1, 2, and 2-hydroxy-4,5,6-trimethoxydihydrochalcone (10) belong to an uncommon group of chalconoids, the retrochalcones. Compound 1 is the first bis-retrochalcone to be reported, and compound 2 is a quinoretrochalcone. Furthermore, 2 showed activity against the MDA‐MB‐231 human breast cancer cell line with an IC50 value of 7.1 µM.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArtic... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5144356 Tue, 16 Aug 2011 23:00:00 +0100 5144356 http://www.medworm.com/index.php?rid=5132537&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280192 Planta MedDOI: 10.1055/s-0031-1280192© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  FREE Full text (Source: Planta Medica) Planta Medica journals http://www.medworm.com/rss/comments.php?id=5132537 Sun, 14 Aug 2011 23:00:00 +0100 5132537 http://www.medworm.com/index.php?rid=5109979&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280087 Planta MedDOI: 10.1055/s-0031-1280087AbstractTen new furanosesquiterpenoids, myrrhterpenoids A–J (1–10), together with eight known analogues (11–18), were isolated from the resinous exudates of Commiphora myrrha. Their structures and relative configurations were elucidated by spectroscopic methods (IR, ESIMS, HRESIMS, 1D and 2D NMR) and by the ChemDraw 3D modeling using MM2. All isolated furanosesquiterpenes showed neuroprotective effects against MPP+-induced neuronal cell death in SH-SY5Y cells.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Planta Medica) Planta Medica journals http://www.medworm.com/rss/comments.php?id=5109979 Mon, 08 Aug 2011 23:00:00 +0100 5109979 http://www.medworm.com/index.php?rid=5109978&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280094 Planta MedDOI: 10.1055/s-0031-1280094AbstractTo investigate the inhibitory effects of Artemisia princeps Pamp. (family Asteraceae) essential oil (APEO) and its main constituents against bacterial vaginosis and vulvovaginal candidiasis, their antimicrobial activities against Gardnerella vaginalis and Candida albicans in vitro and their anti-inflammatory effects against G. vaginalis-induced vaginosis and vulvovaginal candidiasis were examined in mice. APEO and its constituents eucalyptol and α-terpineol were found to inhibit microbe growths. α-Terpineol most potently inhibited the growths of G. vaginalis and C. albicans with MIC values of 0.06 and 0.125 % (v/v), respectively. The antimicrobial activity of α-terpineol was found to be comparable to that of clotrimazole. In... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5109978 Mon, 08 Aug 2011 23:00:00 +0100 5109978 http://www.medworm.com/index.php?rid=5109977&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280022 In this study we assessed the effects of hydroxytyrosol (HT) on inflammatory mediators, cytokines and chemokines, and identified anti-inflammatory constituents of aqueous olive extracts, i.e., olive vegetation water (OVW). Murine macrophages (RAW264.7 cells) were stimulated with lipopolysaccharide (LPS) in the absence or presence of substances; inflammatory mediators [nitric oxide (NO), prostaglandin E2 (PGE2), cytokines, interleukins, chemokines] were determined by the Griess reaction, EIA, or multiplex ELISA (Luminex technology). Expression of inflammatory genes was determined by RT‐PCR. Aqueous olive extracts were fractionated by preparative HPLC and the fractions investigated for their effects on NO and PGE2 production. Results were further analyzed by principal component analysi... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5109977 Mon, 08 Aug 2011 23:00:00 +0100 5109977 http://www.medworm.com/index.php?rid=5109976&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280097 Planta MedDOI: 10.1055/s-0031-1280097AbstractTwo new angucyclines, named (2R,3R)-2-hydroxy-8-O-methyltetrangomycin (1) and (2R,3R)-2-hydroxy-5-O-methyltetrangomycin (2), together with eight known compounds (3–10), were isolated from the culture of Amycolatopsis sp. HCa1, a rare actinobacteria isolated from the gut of Oxya chinensis. The new structures were elucidated through extensive spectroscopic data analysis, and their absolute configurations were assigned by application of the modified Mosher's method and CD spectrum comparison. Their in vitro cytotoxic activities against four cell lines including human cervical cancer cell line (HeLa), human gastric adenocarcinoma cell line (SGC-7901), human lung adenocarcinoma cell line (SPC‐A‐1), and mouse macrophage cell line (RA... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5109976 Mon, 08 Aug 2011 23:00:00 +0100 5109976 http://www.medworm.com/index.php?rid=5184568&cid=s_36620_13_f&fid=36620&url=https%3A%2F%2Fwww.thieme-connect.com%2Fejournals%2Ftoc%2Fplantamedica%2F106867%2Fgrouping%2F106252 Planta Medica 2011; 13Article in Thieme eJournals:Table of contents  |  Congress (Source: Planta Medica) Planta Medica journals http://www.medworm.com/rss/comments.php?id=5184568 Thu, 04 Aug 2011 23:00:00 +0100 5184568 http://www.medworm.com/index.php?rid=5080314&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280023 This study indicates that caspase 3/7 activation is one of the modes of induction of apoptosis for compounds 1, 3, and 4 in CCRF‐CEM cells. The results of the antiangiogenic assay indicated that compounds 1, 3, and 4 were also able to inhibit the growth of blood capillaries on the chorioallantoic membrane of quail eggs, the best effect being noted for compound 4 (54.1 % inhibition).The results of the present work provide evidence of the cytotoxic potential of the four studied flavonoids and supportive data for further investigations.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Planta Medica) Planta Medica journals http://www.medworm.com/rss/comments.php?id=5080314 Wed, 27 Jul 2011 23:00:00 +0100 5080314 http://www.medworm.com/index.php?rid=5080313&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280017 In conclusion, exposure to opium in diabetic patients may be positively associated with the risk of CAD, and with the angiographically determined severity and extent of the disease. Furthermore, dosage of opium consumption may correlate with severity of CAD.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Planta Medica) Planta Medica journals http://www.medworm.com/rss/comments.php?id=5080313 Wed, 27 Jul 2011 23:00:00 +0100 5080313 http://www.medworm.com/index.php?rid=5080312&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280092 Planta MedDOI: 10.1055/s-0031-1280092AbstractA series of naphthoquinones was tested for activity against both extracellular promastigote and intracellular amastigote Leishmania major GFP in vitro. In parallel, the compounds were evaluated for cytotoxic effects against bone marrow-derived macrophages (BMMΦ) as a mammalian host cell control. Most of the compounds noticeably inhibited the growth of extracellular parasites (IC50 0.5 to 6 µM) and the intracellular survival of L. major GFP amastigotes (IC50 1 to 7 µM) when compared with the antileishmanial drug amphotericin B (IC50 of 2.5 and 0.2 µM, respectively). In general, antiprotozoal activity and host cell cytotoxicity seemed to increase in parallel. Conspicuously, the cytotoxic effect was less pronounced on inf... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5080312 Wed, 27 Jul 2011 23:00:00 +0100 5080312 http://www.medworm.com/index.php?rid=5080311&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280093 Planta MedDOI: 10.1055/s-0031-1280093AbstractThree new compounds, including a sesquiterpenoid glucoside gallate, 2Z,4E,1′R,2′S,4′R,6′S-dihydrophaseic acid 4′-O-(6′′-O-galloyl)-β-D-glucopyranoside (1), two new phenolic glucoside gallates, 4-hydroxy-3,5-dimethoxybenzoic acid 4-O-(6′-O-galloyl)-β-D-glucopyranoside (2) and 3,4-dimethoxyphenol 1-O-(6′-O-galloyl)-β-D-glucopyranoside (3), together with eight known compounds (4–11), have been isolated from the stems of Lagerstroemia balansae. Their structures were elucidated on the basis of chemical and spectroscopic evidences.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Planta ... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5080311 Wed, 27 Jul 2011 23:00:00 +0100 5080311 http://www.medworm.com/index.php?rid=5080310&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280086 Planta MedDOI: 10.1055/s-0031-1280086AbstractChemical studies on the constituents from the dragon's blood of Dracaena cambodiana led to the discovery of three new flavonoid derivatives (1–3) and six known compounds (4–9). The structures of the three new compounds were elucidated by NMR and MS spectroscopic analyses. All compounds were evaluated for their growth inhibitory activity against human cell lines K-562, SMMC-7721, and SGC-7901, as well as antibacterial activities against Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (MRSA). As a result, compounds 1, 2, 5, 7, and 9 showed cytotoxicity against K-562, SMMC-7721, and SGC-7901 cell lines. All these compounds were observed to exhibit antibacterial activities against S. aureus, and compounds 1–4,... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5080310 Wed, 27 Jul 2011 23:00:00 +0100 5080310 http://www.medworm.com/index.php?rid=5080309&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280091 Planta MedDOI: 10.1055/s-0031-1280091AbstractThe phytochemical investigation of the ethanolic extract of the whole plants of Geum japonicum Thunb. var. chinense F. Bolle yielded four new compounds: 20β,28-epoxy-28-hydroxytaraxasteran-3β-ol (1), (7R,8R)-4-hydroxy-9′-O-(α-L-rhamnopyranosyl)-3,3′,5′-trimethoxy-8-O-4′-neolignan (2), (7R,8S)-4-hydroxy-9′-O-(α-L-rhamnopyranosyl)-3,3′,5′-trimethoxy-8-O-4′-neolignan (3), and (7S,8S)-5-methoxycupressoside A (4), as well as 40 other known compounds. Structures were elucidated by physical, chemical, and spectroscopic methods, including 1D and 2D NMR, HRESIMS, and CD experiments. The taraxasterane-type triterpene (1) and lignans (2–6) are reported for the first time from the Geu... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5080309 Wed, 27 Jul 2011 23:00:00 +0100 5080309 http://www.medworm.com/index.php?rid=5070394&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280064 Planta MedDOI: 10.1055/s-0031-1280064AbstractFour new biphenyl and biphenyl ether quinolizidine N-oxide alkaloids, 5-epi-dihydrolyfoline N-oxide (1), decamine N-oxide (2), lagerstroemine N-oxide (3), and lagerine N-oxide (4), were isolated from the aerial parts of Lagerstroemia indica, and their structures were established by extensive spectroscopic studies. In addition, the inhibitory effects of isolated compounds on rat lens aldose reductase (RLAR) were examined.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Planta Medica) Planta Medica journals http://www.medworm.com/rss/comments.php?id=5070394 Tue, 26 Jul 2011 23:00:00 +0100 5070394 http://www.medworm.com/index.php?rid=5070393&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280096 Planta MedDOI: 10.1055/s-0031-1280096AbstractThree new phenolic compounds, thamnoliadepsides A (1), B (2), and thamnolic acid A (3), and seven known compounds, everninic acid (4), baeomycesic acid (5), β-orcinol (6), β-resorcylic acid (7), ethyl orsellinate (8), squamatic acid (9), and vermicularin (10), were isolated from the lichen Thamnolia vermicularis (Sw.) Ach. ex Schaerer. Their structures were determined based on spectroscopic analysis, including 2D‐NMR experiments and HR‐MS techniques. Compound 1 inhibited growth of prostate cancer cells and bonded to G-quadruplex DNA based on NMR determination.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Planta Medica) Planta Medica journals http://www.medworm.com/rss/comments.php?id=5070393 Tue, 26 Jul 2011 23:00:00 +0100 5070393 http://www.medworm.com/index.php?rid=5053260&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1271158 Planta Med 2011; 77: 1069-1070DOI: 10.1055/s-0030-1271158© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Full text (Source: Planta Medica) Planta Medica journals http://www.medworm.com/rss/comments.php?id=5053260 Thu, 21 Jul 2011 23:00:00 +0100 5053260 http://www.medworm.com/index.php?rid=5053259&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280024 Planta MedDOI: 10.1055/s-0031-1280024AbstractTen new polyhydroxyolean-12-ene pentacyclic triterpenoidal saponins, named rogchaponins 1–10, were isolated from the methanolic extract of the roots of Camellia sinensis by a series of chromatographic methods (silica gel flash column and C18 MPLC followed by C18 HPLC). Their structures were established by 1D and 2D‐NMR techniques along with IR and HR‐TOF‐MS. Rogchaponins R4 (4) and R5 (5) showed inhibitory activities against yeast alcohol dehydrogenase (ADH) with IC50 values of 16.1 ± 3.2 and 15.4 ± 3.3 µM, respectively. A 4-methylpyrazole positive control exhibited an IC50 of 2750 ± 50 µM. However, the saponins showed no inhibitory activity against yeast aldehyde dehyd... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5053259 Thu, 21 Jul 2011 23:00:00 +0100 5053259 http://www.medworm.com/index.php?rid=5053258&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280054 Planta MedDOI: 10.1055/s-0031-1280054AbstractThe resistance to chemotherapeutic drugs by cancer cells is considered to be one of the major obstacles for success in the treatment of cancer. A major mechanism underlying this multidrug resistance is the overexpression of P-glycoprotein (P‐gp), resulting in insufficient drug delivery to the tumor sites. A previous study has shown that stemofoline, an alkaloid isolated from Stemona burkillii, could enhance the sensitivity of chemotherapeutics in a synergistic fashion. In the present study, we have focused on the effect of stemofoline on the modulation of P‐gp function in a multidrug resistant human cervical carcinoma cell line (KB‐V1). The effects of stemofoline on a radiolabeled drug, [3H]-vinblastine, and fluorescent P&#8208... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5053258 Thu, 21 Jul 2011 23:00:00 +0100 5053258 http://www.medworm.com/index.php?rid=5030893&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1271196 Planta MedDOI: 10.1055/s-0030-1271196AbstractThree new cycloartane triterpenoids have been isolated from Astragalus bicuspis Fisch. Their structures were elucidated as 23(R),24(S),25(R),26(S)-16β/23,23/26,24/25-triepoxy-26-hydroxy-9,19-cyclolanosta-3,6-dione (1), 6α,23,24,25-tetraol-16β-acetoxy-23(R),24(R)-9,19-cyclanosta-3-one (2), and 6α,23,24,25-tetraol-16β-acetoxy-23(R),24(R)-9,19-cyclolanosta-3β-O-xyloside (3), based on their spectroscopic analysis. All cycloartane tritepenoids exhibited weak cytotoxicities against 3T3 fibroblast cells as compared to the standard drug cycloheximide. Compounds 3 and 4 were also tested for their antileishmanial potential, and a weak activity was observed against promastigotes of Leishmania major.[...]© Georg Thieme Verlag ... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5030893 Thu, 14 Jul 2011 23:00:00 +0100 5030893 http://www.medworm.com/index.php?rid=5030892&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1279995 Planta MedDOI: 10.1055/s-0031-1279995AbstractFive new (1–5) and twelve known (6–17) different types of glycosides together with a known sesquiterpene triol (18) were isolated from the methanol extract of the rhizomes of Notopterygium incisum. The new structures were elucidated by means of spectroscopic and chemical methods to be pregn-5-en-3β,20(S)-diol-3-O-bis-β-D-glucopyranosyl-(l → 2,1 → 6)-β-D-glucopyranoside (1), oleuropeic aldehyde 8-O-β-D-glucopyranoside (2), 2(R)-(3,4-dimethoxyphenyl)-propane-1,3-diol-1-O-β-D-glucopyranoside (3), eudesman-3α,4α,11-triol-11-O-β-D-glucopyranoside (4), and marmesin-11-O-β-D-glucopyranosyl-(1 → 6)-β-D-glucopyranoside (5). The absolute con... Planta Medica journals http://www.medworm.com/rss/comments.php?id=5030892 Thu, 14 Jul 2011 23:00:00 +0100 5030892 http://www.medworm.com/index.php?rid=4999483&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280008 Planta MedDOI: 10.1055/s-0031-1280008AbstractPolyphenol-aspirin interactions were recently identified; however, the interaction mode and underlying mechanisms remained elusive. Here, we quantitatively assessed the potential interactions among two important polyphenolic compounds, caffeic acid (CA) and protocatechualdehyde (Pro), and aspirin in the AA-induced platelet aggregation model by applying the isobologram and universal response surface approach (URSA) methods. A molecular docking approach and an originally developed platelet-associated aspirin clearance approach (PAACA) were then applied to explore the potential interaction mechanisms. Although Pro and CA themselves exhibited weak inhibitory effect on arachidonic acid (AA)-induced platelet aggregation and the production of thromboxa... Planta Medica journals http://www.medworm.com/rss/comments.php?id=4999483 Sun, 03 Jul 2011 23:00:00 +0100 4999483 http://www.medworm.com/index.php?rid=4999482&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1279997 In this study, the metabolic characterization of Withania somnifera leaves, stems, and roots collected in six different regions in India was performed using 1H NMR spectroscopy followed by principal component analysis (PCA) and hierarchical clustering analysis (HCA). Of the parts of Withania somnifera analyzed in this study, the leaf was found to have the widest range of metabolites, including amino acids, flavonoids, lipids, organic acids, phenylpropanoids, and sugars, as well as the main secondary metabolites of the plant, withanolides. The 1H NMR spectra revealed the presence of two groups of withanolides: 4-OH and 5,6-epoxy withanolides (withaferin A-like steroids) and 5-OH and 6,7-epoxy withanolides (withanolides A-like steroids). The ratio of these two withanolides was found to be a ... Planta Medica journals http://www.medworm.com/rss/comments.php?id=4999482 Sun, 03 Jul 2011 23:00:00 +0100 4999482 http://www.medworm.com/index.php?rid=4999481&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1271199 Planta MedDOI: 10.1055/s-0030-1271199AbstractAn investigation of alkaloids present in the leaves and stems of Tylophora ovata led to the isolation of two new septicine alkaloids and one new phenanthroindolizidine alkaloid, tylophovatines A, B, C (1, 2, and 5), respectively, together with two known septicine and six known phenanthroindolizidine alkaloids. The structures of the new alkaloids 1, 2, and 5 were established by means of spectroscopic analyses. These eleven alkaloids show in vitro anti-inflammatory activities with IC50 values ranging from 84 nM to 20.6 µM through their suppression of nitric oxide production in RAW 264.7 cells stimulated by lipopolysaccharide and interferon-γ. Moreover, these substances display growth inhibition in HONE-1, NUGC-3, HepG2, SF-268, M... Planta Medica journals http://www.medworm.com/rss/comments.php?id=4999481 Sun, 03 Jul 2011 23:00:00 +0100 4999481 http://www.medworm.com/index.php?rid=4999480&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280020 Planta MedDOI: 10.1055/s-0031-1280020AbstractSeven new compounds, including four lignans, (+)-(8S,8′S)-9,9′-dibenzoylsecoisolariciresinol (1), (+)-(8S*,8′R*)-4,4′-dimethyloxomatairesinol (2), (+)-(7S*,8R*,8′R*,9′S*)-9′-n-butoxytsugacetal (3), and pseudolarkaemin A (4), a pyronane glycoside, pseudolarkaemin B (5), an ent-beyerene glycoside, pseudolarkaemin C (6), and a triterpene, 25-epi-pseudolarolide Q (7), along with 25 known compounds (8–32) were isolated from the twigs of Pseudolarix kaempferi. Their structures were elucidated mainly by the analysis of their NMR and MS data. Pseudolarolide C acid (24) was isolated for the first time as a natural product. All compounds were evaluated for antimicrobial activity against Candida albicans and ... Planta Medica journals http://www.medworm.com/rss/comments.php?id=4999480 Sun, 03 Jul 2011 23:00:00 +0100 4999480 http://www.medworm.com/index.php?rid=4999479&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1279992 Planta MedDOI: 10.1055/s-0031-1279992AbstractThe aim of this study was to investigate the antiobesity and antihyperlipidemic effects of the flavonoid kaempferol (3,5,7,4′-tetrahydroxyflavone). After being fed a high-fat diet (HFD) for two weeks, rats were dosed orally with kaempferol (75, 150, or 300 mg/kg) or fenofibrate (100 mg/kg) once daily for eight weeks. Fenofibrate is an antilipemic agent that exerts its therapeutic effects through activation of peroxisome proliferator-activated receptor α (PPARα). Kaempferol (300 mg/kg/day) produced effects similar to fenofibrate in reducing body weight gain, visceral fat-pad weights, plasma lipid levels, as well as the coronary artery risk and atherogenic indices of HFD-fed rats. Kaempferol also caused dose-relat... Planta Medica journals http://www.medworm.com/rss/comments.php?id=4999479 Sun, 03 Jul 2011 23:00:00 +0100 4999479 http://www.medworm.com/index.php?rid=4999487&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1271185 Planta MedDOI: 10.1055/s-0030-1271185AbstractEight new flavonoids, including three pterocarpene derivatives, hirtellanines C–E, two flavanones, hirtellanines F and G, three isoflavanones, hirtellanines H–J, as well as four known compounds were isolated from the roots of Campylotropis hirtella. The structures of the new compounds were elucidated by spectroscopic analyses, including 2D‐NMR techniques. Pharmacological investigation indicated that the new compounds, particularly hirtellanines D and G, possessed potent immunosuppressive activities and low relative cytotoxicities.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Planta Medica) Planta Medica journals http://www.medworm.com/rss/comments.php?id=4999487 Tue, 14 Jun 2011 23:00:00 +0100 4999487 http://www.medworm.com/index.php?rid=4999486&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1279984 Planta MedDOI: 10.1055/s-0031-1279984AbstractCarlina acaulis (Asteraceae) has a long history of medicinal use in Europe due to its antimicrobial properties. The strong activity of Carlina oxide, the main compound of the essential oil of C. acaulis against two MRSA strains, Streptococcus pyogenes, Pseudomonas aeruginosa, Candida albicans, and C. glabrata was confirmed. A strong and selective activity against Trypanosoma brucei brucei with an IC50 of 1.0 µg/mL and a SI of 446 compared to human HeLa cells was recorded. The selective toxicity of Carlina oxide makes it a promising lead compound for the development of drugs to treat African trypanosomiasis and multiresistant gram-positive bacteria.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of con... Planta Medica journals http://www.medworm.com/rss/comments.php?id=4999486 Tue, 14 Jun 2011 23:00:00 +0100 4999486 http://www.medworm.com/index.php?rid=4999485&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1271198 Planta MedDOI: 10.1055/s-0030-1271198AbstractBaliospermum montanum leaves yielded 3-hydroxy-2,4-dimethoxy-10-methyl-9-acridanone (1), an alkaloid from the CHCl3 fraction. Spectroscopic analysis was performed to assign the structure of the new compound (1) and its absolute configuration. The compound was evaluated for its effect in anaphylaxis by estimation of the release of histamine in systemic anaphylaxis model. The acridanone alkaloid significantly inhibited the degranulation of mast cells up to 65.22 % and 75.12 % at a dose of 50 and 75 mg/kg, respectively.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Planta Medica) Planta Medica journals http://www.medworm.com/rss/comments.php?id=4999485 Tue, 14 Jun 2011 23:00:00 +0100 4999485 http://www.medworm.com/index.php?rid=4999484&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1271190 Planta MedDOI: 10.1055/s-0030-1271190AbstractAn HPLC-ESIMSn method, based on high-performance liquid chromatography coupled to electrospray positive ionization multistage ion trap mass spectrometry, has been used to rapidly identify and guide the isolation of phenolic constituents from the methanol extract of the aerial parts of T. cinerea. On the basis of the results of the online screening by HPLC-ESIMSn, 17 phenolic constituents, including two new compounds, namely demethylapollinin 7-O-β-D-glucopyranoside (1) and cineroside A (17), were isolated, and their structures were unambiguously assigned by the extensive use of 1D- and 2D‐NMR experiments.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text... Planta Medica journals http://www.medworm.com/rss/comments.php?id=4999484 Tue, 14 Jun 2011 23:00:00 +0100 4999484 http://www.medworm.com/index.php?rid=4999497&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1271187 Planta MedDOI: 10.1055/s-0030-1271187AbstractPanama is a unique terrestrial bridge of extreme biological importance. It is one of the “hot spots” and occupies the fourth place among the 25 most plant-rich countries in the world, with 13.4 % endemic species. Panamanian plants have been screened for a wide range of biological activities: as cytotoxic, brine shrimp-toxic, antiplasmodial, antimicrobial, antiviral, antioxidant, immunosuppressive, and antihypertensive agents. This review concentrates on ethnopharmacological uses of medicinal plants employed by three Amerindian groups of Panama and on selected plants with novel structures and/or interesting bioactive compounds. During the last quarter century, a total of approximately 390 compounds from 86 plants have been isola... Planta Medica journals http://www.medworm.com/rss/comments.php?id=4999497 Mon, 13 Jun 2011 23:00:00 +0100 4999497 http://www.medworm.com/index.php?rid=4999496&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1279978 Planta MedDOI: 10.1055/s-0031-1279978AbstractEquitable sharing of the benefits of biodiversity is one of the main objectives of the Convention on Biological Diversity (CBD). Yet understanding of the CBD rules and principles on access and benefit sharing, as well as how they apply to biodiversity-based research and development remains limited. In October 2010, the CBD adopted additional rules on access and benefit sharing. These rules – known as the Nagoya Protocol – provide clarification on several important issues, including the applicability of access and benefit sharing to research on biochemical compounds and processes. As a result, the Nagoya Protocol constitutes an important opportunity for institutions, organizations, and companies committed to ethical practices regardin... Planta Medica journals http://www.medworm.com/rss/comments.php?id=4999496 Mon, 13 Jun 2011 23:00:00 +0100 4999496 http://www.medworm.com/index.php?rid=4999495&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1271157 Planta MedDOI: 10.1055/s-0030-1271157AbstractAlthough dihydroartemisinin (DHA) and other artemisinin derivatives have selective toxicity towards cancer cells, Artemisia annua (A. annua) extracts containing artemisinin have not been evaluated for their anticancer potential. Our main goal was to assess the anticancer effect of ethanolic leaf extracts of A. annua from Brazilian and Chinese origins (with DHA as a comparison) on normal and cancer cells. Leukocytes and leukemia (Molt-4) cells were counted at 0, 24, 48, and 72 hr after treatment with extracts having artemisinin concentrations of 0, 3.48, 6.96, and 13.92 µg/mL. Also, we assessed the antioxidant capacity of these extracts using the oxygen radical absorbance capacity (ORAC) test. Both extracts had high antioxidant capa... Planta Medica journals http://www.medworm.com/rss/comments.php?id=4999495 Mon, 13 Jun 2011 23:00:00 +0100 4999495 http://www.medworm.com/index.php?rid=4999494&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1271200 In this study, a rapid resolution liquid chromatography-diode array detection/electrospray ionization tandem mass spectrometry (RRLC/DAD/ESI‐MSn) method was developed for the comparative analysis of the components of Heshouwu and Zhi-heshouwu. A total of 23 compounds were identified or tentatively characterized. We found that 16 batches of Heshouwu and 15 batches of Zhi-heshouwu samples shared eight compounds, including gallic acid; 3,5,4′-tetrahydroxylstilbene-2,3-di-O-glucoside, cis-2,3,5,4′-tetrahydroxylstilbene-2-O-β-D-glucoside, trans-2,3,5,4′-tetrahydroxylstilbene-2-O-β-D-glucoside, emodin-8-O-β-D-glucoside, physcion-8-O-β-D-glucoside, emodin, and physcion. Nevertheless, the relative amounts of gallic acid, emodin, and physcion were very hi... Planta Medica journals http://www.medworm.com/rss/comments.php?id=4999494 Mon, 13 Jun 2011 23:00:00 +0100 4999494 http://www.medworm.com/index.php?rid=4999493&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1271186 Planta MedDOI: 10.1055/s-0030-1271186AbstractCuscuta chinensis and Cuscuta australis, the two botanical sources of the Chinese herbal medicine Tu-Si-Zi, were distinguished from each other based on qualitative and quantitative chemical analysis. By HPLC‐DAD‐MS, a total of 36 compounds were characterized from these two Cuscuta species, including 14 flavonoids, 17 quinic acid derivatives, and 5 lignans. In addition, HPLC‐UV was applied to determine seven major compounds (6 flavonoids plus chlorogenic acid) in 27 batches of Tu-Si-Zi. The results revealed that the amounts of the three classes of compounds varied significantly between the species. C. australis contained more flavonoids but less quinic acid derivatives and lignans than C. chinensis. Particularly, the amounts of ... Planta Medica journals http://www.medworm.com/rss/comments.php?id=4999493 Mon, 13 Jun 2011 23:00:00 +0100 4999493 http://www.medworm.com/index.php?rid=4999492&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1279983 Planta MedDOI: 10.1055/s-0031-1279983AbstractDiabetes mellitus is the most common metabolic disorder affecting millions worldwide. It is recognized as a global major health problem. As alternatives to the available orthodox medicines, plants are considered a potential source for the treatment of diabetes within traditional ethnomedicine practices. In the Jordanian traditional medicine a significant selection of ethnobotanicals is promoted for their antidiabetic activity. Literature surveys demonstrate the benefit of several ethnobotanicals as antidiabetic agents evaluated in in vitro and in vivo systems in the form of their crude extracts and/or isolated pure compounds with varying degrees of hypoglycemic or antihyperglycemic bioactivities. This mini review discusses the preparatory forms ... Planta Medica journals http://www.medworm.com/rss/comments.php?id=4999492 Mon, 13 Jun 2011 23:00:00 +0100 4999492 http://www.medworm.com/index.php?rid=4999491&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1271179 Planta MedDOI: 10.1055/s-0030-1271179AbstractFive new 1,3-diarylpropan-1-ols, combretol A–E (1–5), together with one known coumarin (6) and ten known triterpenes (7–16), were isolated from Combretum yunnanense. Their structures were determined by spectroscopic investigation, including 1H and 13C NMR, NOESY, HSQC, HMBC, and HRESIMS analyses. This is the first report on the occurrence of 1,3-diarylpropan-1-ols and coumarin in the Combretum genus including C. yunnanense. Also, to the best of our knowledge, 1,3-diarylpropan-1-ols are rare in nature.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Planta Medica) Planta Medica journals http://www.medworm.com/rss/comments.php?id=4999491 Mon, 13 Jun 2011 23:00:00 +0100 4999491 http://www.medworm.com/index.php?rid=4999490&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1271178 Planta MedDOI: 10.1055/s-0030-1271178AbstractOne new drimane-type sesquiterpenoid, 3β-angeloyloxy-7-epifutronolide (1), and one new natural product, polygonumate (2), along with six known drimane-type sesquiterpenes [dendocarbin L (3), (+) winterin (4), (+) fuegin (5), changweikangic acid A (6), futronolide (7), and 7-ketoisodrimenin (8)] were isolated from the whole plant of Polygonum hydropiper Linn. Their structures were determined using spectroscopic techniques. Single-crystal X‐ray diffraction study on dendocarbin L (3) and 13C‐NMR spectroscopic data of (+) winterin (4) are described for the first time. Compound 6 was evaluated for inhibitions of α-chymotrypsin, acetylcholinesterase, and butyrylcholinesterase enzymes.[...]© Georg Thieme Verlag KG Stuttgart · Ne... Planta Medica journals http://www.medworm.com/rss/comments.php?id=4999490 Mon, 13 Jun 2011 23:00:00 +0100 4999490 http://www.medworm.com/index.php?rid=4999489&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1279994 Planta MedDOI: 10.1055/s-0031-1279994AbstractThe dichloromethane extract of the flowers of Helianthus angustifolius L. (Asteraceae, Heliantheae) was investigated in vitro for its cytotoxic activity using human cancer cell lines: CCRF‐CEM leukemia, MDA‐MB‐231 breast cancer, U251 glioblastoma, HCT 116 colon cancer cells, and the human lung fibroblast cell line MRC-5. Cytotoxicity-guided fractionation led to the isolation of four related heliangolide-type sesquiterpene lactones. The structures were elucidated by means of NMR spectroscopy and high-resolution mass spectrometry. Of the investigated compounds, 8-methacrylyl-4,15-iso-atriplicolide (1) showed the highest activity against all tested cancer cell lines with IC50 values ranging from 0.26 ± 0.01 µM ... Planta Medica journals http://www.medworm.com/rss/comments.php?id=4999489 Mon, 13 Jun 2011 23:00:00 +0100 4999489 http://www.medworm.com/index.php?rid=4999488&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1271197 Planta MedDOI: 10.1055/s-0030-1271197AbstractTwo new tirucallane triterpenoids, 24,25-epoxy-3β-hydroxy-20-oxo-7-tirucallene (1) and 22,23;24,25-diepoxy-3β-hydroxy-7-tirucallene (2), and a new tetranortriterpenoid, 4α-hydroperoxy-6-O-acetylnimbandiol (3), along with eight known compounds, were isolated from the branches and leaves of Azadirachta indica. Their structures were elucidated through spectroscopic and chemical methods. The cytotoxic assay showed that the abundant constituent nimbolide (8) had obvious cytotoxic activities against HL-60, SMMC7721, A549, MCF-7, and SW-480 cell lines, with IC50 values of 0.8 ± 0.1, 2.2 ± 0.2, 1.9 ± 1.3, 4.5 ± 1.1, and 2.3 ± 0.1 µM, respectively.[...]© Georg Thieme ... Planta Medica journals http://www.medworm.com/rss/comments.php?id=4999488 Mon, 13 Jun 2011 23:00:00 +0100 4999488 http://www.medworm.com/index.php?rid=4999498&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0031-1280009 Planta MedDOI: 10.1055/s-0031-1280009© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  FREE Full text (Source: Planta Medica) Planta Medica journals http://www.medworm.com/rss/comments.php?id=4999498 Wed, 08 Jun 2011 23:00:00 +0100 4999498 http://www.medworm.com/index.php?rid=4999500&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1271159 In conclusion, M S/G was the major form in circulation, whereas M was predominant in the liver, kidney, brain, lung, and heart after oral administration of M; among these organs, the liver contained the highest concentrations of M and MG.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Planta Medica) Planta Medica journals http://www.medworm.com/rss/comments.php?id=4999500 Tue, 31 May 2011 23:00:00 +0100 4999500 http://www.medworm.com/index.php?rid=4999499&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1271154 Planta MedDOI: 10.1055/s-0030-1271154AbstractA cytotoxicity-guided fractionation of the roots of Galianthe thalictroides afforded a new β-carboline alkaloid, 1-(hydroxymethyl)-3-(2-hydroxypropan-2-yl)-2-(5-methoxy-9H-β-carbolin-1-yl)cyclopentanol, which exhibited strong cytotoxic activity against three human cancer cell lines (MCF-7, 786-0, and UACC62). Its structure was established on the basis of 1D- and 2D-NMR spectroscopic techniques supported by HRMS data.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Planta Medica) Planta Medica journals http://www.medworm.com/rss/comments.php?id=4999499 Tue, 31 May 2011 23:00:00 +0100 4999499 http://www.medworm.com/index.php?rid=4999504&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1271132 Planta MedDOI: 10.1055/s-0030-1271132AbstractEGFR, as a critical signaling pathway in many human tumors, has become an important target of cancer drug design. Taspine has shown meaningful angiogenesis activity in previous studies. This paper is to investigate the antitumor action of taspine by modulating the EGFR signaling pathway. The study determined the expression of key signaling molecules of EGFR (EGFR, Akt, p-Akt, Erk, and p-Erk) by Western blot and real-time PCR and analyzed their correlations with subsequent reactions. In addition, the cell proliferation, migration, and EGF production were examined by MTT, transwell system, and ELISA. The antitumor activity in vivo was carried out by xenograft in athymic mice. The results showed that taspine could inhibit A431 and Hek293/EGFR cell ... Planta Medica journals http://www.medworm.com/rss/comments.php?id=4999504 Tue, 24 May 2011 23:00:00 +0100 4999504 http://www.medworm.com/index.php?rid=4999503&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1271153 Planta MedDOI: 10.1055/s-0030-1271153AbstractTwo new diterpenoid compounds, ginkgolide P (1) and ginkgolide Q (2), were isolated from the leaves of Ginkgo biloba L. Their structures were elucidated by various spectroscopic methods, and the structure of 1 was further confirmed by X‐ray crystallographic analysis. The activities of the compounds were evaluated against platelet aggregation induced by platelet activating factor (PAF), and the preliminary structure-activity relationship was also discussed.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Planta Medica) Planta Medica journals http://www.medworm.com/rss/comments.php?id=4999503 Tue, 24 May 2011 23:00:00 +0100 4999503 http://www.medworm.com/index.php?rid=4999502&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1271135 Planta MedDOI: 10.1055/s-0030-1271135AbstractAstilbin is a flavonoid compound isolated from the rhizome of Smilax china L. The effects and possible mechanisms of astilbin on hyperuricemia and nephropathy rats were elucidated in this study. Different dosages of astilbin (1.25, 2.5, and 5.0 mg/kg) were administered to 10 % fructose-induced hyperuricemic rats. The results demonstrated that astilbin significantly decreased the serum uric acid (Sur) level by increasing the urinary uric acid (Uur) level and fractional excretion of urate (FEUA) but not inhibiting the xanthine oxidase (XOD) activity. In addition, kidney function parameters such as serum creatinine (Scr) and blood urea nitrogen (BUN) were recovered in astilbin-treated hyperuricemic rats. Further investigation indicated ... Planta Medica journals http://www.medworm.com/rss/comments.php?id=4999502 Tue, 24 May 2011 23:00:00 +0100 4999502 http://www.medworm.com/index.php?rid=4999501&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1271119 Planta MedDOI: 10.1055/s-0030-1271119AbstractDevelopment of early stage atherosclerosis involves the activation of endothelial cells by oxidized low-density lipoprotein (oxLDL) with subsequent increases in endothelial permeability and expression of adhesion molecules favoring the adherence of monocytes to the endothelium. Cryptotanshinone (CTS), a major compound derived from the Chinese herb Salvia miltiorrhiza, is known for its protective effects against cardiovascular diseases. The aim of this study was to determine whether CTS could prevent the oxLDL-induced early atherosclerotic events. OxLDL (100 µg/mL) was used to increase endothelial permeability and induce monocyte-endothelial cell adhesion in human umbilical vein endothelial cells (HUVECs). Endothelial nitric oxide (NO) con... Planta Medica journals http://www.medworm.com/rss/comments.php?id=4999501 Tue, 24 May 2011 23:00:00 +0100 4999501 http://www.medworm.com/index.php?rid=4999505&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1271138 Planta MedDOI: 10.1055/s-0030-1271138AbstractFour new polyacetylenes, namely chrysindins A–D (1–4), together with 6 known polyacetylenes, were isolated from the flowers of Chrysanthemum indicum. Their structures were established on the basis of comprehensive spectroscopic analyses. Chrysindins A (1) and B (2) bear a novel carbon skeleton.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Planta Medica) Planta Medica journals http://www.medworm.com/rss/comments.php?id=4999505 Thu, 19 May 2011 23:00:00 +0100 4999505 http://www.medworm.com/index.php?rid=4848760&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1271138 Planta MedDOI: 10.1055/s-0030-1271138AbstractFour new polyacetylenes, namely chrysindins A-D (1-4), together with 6 known polyacetylenes, were isolated from the flowers of Chrysanthemum indicum. Their structures were established on the basis of comprehensive spectroscopic analyses. Chrysindins A (1) and B (2) bear a novel carbon skeleton.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Planta Medica) Planta Medica journals http://www.medworm.com/rss/comments.php?id=4848760 Thu, 19 May 2011 23:00:00 +0100 4848760 http://www.medworm.com/index.php?rid=4848759&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1271120 Planta MedDOI: 10.1055/s-0030-1271120AbstractThe present study assessed the absolute and relative bioavailabilities of dodeca-2E,4E,8Z,10E/Z-tetraenoic acid isobutylamides (tetraenes), the main bioactive constituents in Echinacea, administered as pure compounds or in the form of an Echinacea purpurea root extract preparation. Tetraenes were administered orally by gavage or intravenously in a dose of 0.75 mg/kg. The extract was administered orally in a dose of 158.6 mg/kg which corresponds to the same amount of tetraenes. Pharmacokinetic parameters of tetraenes were calculated by non-compartmental analysis using WinNonlin® 5.2 software. Mean dodeca-2E,4E,8Z,10E/Z-tetraenoic acid isobutylamide dose-normalized plasma area under the concentration-time curve (AUC0-∞/dose) was 3.24 ± 0.3... Planta Medica journals http://www.medworm.com/rss/comments.php?id=4848759 Thu, 19 May 2011 23:00:00 +0100 4848759 http://www.medworm.com/index.php?rid=4832184&cid=s_36620_13_f&fid=36620&url=http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-0030-1271073 Planta MedDOI: 10.1055/s-0030-1271073AbstractOlive oil has been shown to exhibit beneficial effects in the prevention of cardiovascular diseases although its molecular mechanism still remains unclear. In the present study, we investigated the effect of hydroxytyrosol (HT), a major phenolic component in olive oil and leaves from Olea europaea L. (Oleaceae family), on vascular smooth muscle cells (VSMCs) survival, migration, and apoptosis. HT treatment resulted in a dose-dependent decrease of cell survival and migration in the presence or absence of platelet-derived growth factor (PDGF) by inducing apoptosis of VSMCs. HT enhanced nitric oxide (NO) production in a dose-dependent manner, and the NO synthase inhibitor L-NMMA blocked HT-mediated effects on VSMCs survival. HT as well as the NO do... Planta Medica journals http://www.medworm.com/rss/comments.php?id=4832184 Mon, 16 May 2011 23:00:00 +0100 4832184