MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Prenatal Diagnosis' source. Mon, 06 Feb 2012 17:44:33 +0100 http://www.medworm.com/index.php?rid=5635554&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2895 (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5635554 Tue, 24 Jan 2012 05:00:00 +0100 5635554 http://www.medworm.com/index.php?rid=5635553&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2916 ConclusionCordocentesis with placenta penetration carries a higher risk for fetal loss, preterm birth, and low birth weight. This information may be helpful in prenatal diagnosis counseling, and it may encourage performers to avoid placenta penetration, if possible. © 2012 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5635553 Tue, 24 Jan 2012 05:00:00 +0100 5635553 http://www.medworm.com/index.php?rid=5635552&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2919 (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5635552 Tue, 24 Jan 2012 05:00:00 +0100 5635552 http://www.medworm.com/index.php?rid=5604095&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2876 (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5604095 Mon, 16 Jan 2012 05:00:00 +0100 5604095 http://www.medworm.com/index.php?rid=5635551&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.3835 ConclusionAmniotic fluid viral PCR testing should be considered for fetuses with intrauterine growth restriction, nonimmune hydrops fetalis, hand/foot anomalies, or NTDs. After aneuploidy is excluded, NTDs are associated with PCR positivity. © 2012 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5635551 Thu, 01 Dec 2011 05:00:00 +0100 5635551 http://www.medworm.com/index.php?rid=5604094&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2855 ConclusionAneuploidy and genomic imbalances with CNVs as small as 1.2 Mb in a single cell are detectable by array CGH using arrays with high‐density coverage in the targeted regions. This approach has the potential to be applied for preimplantation genetic diagnosis to detect aneuploidy and common microdeletion/duplication syndromes and for noninvasive prenatal diagnosis if single fetal cells can be isolated. © 2012 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5604094 Thu, 01 Dec 2011 05:00:00 +0100 5604094 http://www.medworm.com/index.php?rid=5593192&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2871 ConclusionsScreening for pre‐eclampsia is cost‐effective under various scenarios. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5593192 Thu, 01 Dec 2011 05:00:00 +0100 5593192 http://www.medworm.com/index.php?rid=5569025&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2922 ConclusionDigital analysis of selected regions enables highly accurate, cost efficient, and scalable noninvasive fetal aneuploidy assessment. © 2012 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5569025 Thu, 01 Dec 2011 05:00:00 +0100 5569025 http://www.medworm.com/index.php?rid=5447738&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2886 (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5447738 Sat, 26 Nov 2011 11:54:30 +0100 5447738 http://www.medworm.com/index.php?rid=5375650&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2866 ConclusionUltrasonographic evidence of NVFGB is an additional risk factor for CF in cases with FEB. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5375650 Wed, 02 Nov 2011 04:00:00 +0100 5375650 http://www.medworm.com/index.php?rid=5375649&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2881 ConclusionIn the nitrofen rat model of congenital diaphragmatic hernia, a longer period of TO leads to enhanced lung growth and less muscularized pulmonary arteries. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5375649 Tue, 01 Nov 2011 04:00:00 +0100 5375649 http://www.medworm.com/index.php?rid=5375653&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2848 ConclusionThis combination of maternal biochemical variables in the first trimester can detect a consistent number of late PE. Further studies on a new and independent series of data could confirm the presented results. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5375653 Fri, 28 Oct 2011 04:00:00 +0100 5375653 http://www.medworm.com/index.php?rid=5375652&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2884 ConclusionsThis study demonstrates that aCGH represents an improved diagnostic tool for prenatal detection of chromosomal abnormalities. Although larger studies are needed, our results provide further evidence on the feasibility of introducing aCGH as a first‐line diagnostic test in routine prenatal diagnosis practice. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5375652 Fri, 28 Oct 2011 04:00:00 +0100 5375652 http://www.medworm.com/index.php?rid=5375651&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2885 ConclusionsA reference range of the fetal penile length was constructed, measured from the proximal edge of the corpus cavernosum to the tip of the glans penis at 14 to 35 gestational weeks. This reference range can assist in early identification of true penile maldevelopment, which obligate further diagnostic workup, as opposed to the benign disorder of buried or concealed fetal penis. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5375651 Fri, 28 Oct 2011 04:00:00 +0100 5375651 http://www.medworm.com/index.php?rid=5355441&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2882 ConclusionWe found that the prevalence of HBP carriers is high enough in our population to warrant HBP testing for the entire multiethnic population in early pregnancy at the time of anemia screening. This is feasible as most women had their booking early in their first trimester. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5355441 Fri, 28 Oct 2011 03:38:11 +0100 5355441 http://www.medworm.com/index.php?rid=5355456&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2894 ConclusionRoutine screening of sample handling requires careful monitoring. However, no extra precautions need to be taken when PlGF is used for pre‐eclampsia screening run alongside existing first trimester aneuploidy screening programs that include hCGβ. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5355456 Wed, 26 Oct 2011 04:00:00 +0100 5355456 http://www.medworm.com/index.php?rid=5355455&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2889 ConclusionBecause only a few laboratories offer an NIPD RhD service, we suggest a maximal transport time of 5 days from phlebotomy until freezing at the testing laboratory. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5355455 Wed, 26 Oct 2011 04:00:00 +0100 5355455 http://www.medworm.com/index.php?rid=5355454&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2887 ConclusionBoth the lay persons as well as the medical fraternity in India feel the need to look into revision of legalisation of LTOP particularly for fetal conditions with poor outcome. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5355454 Wed, 26 Oct 2011 04:00:00 +0100 5355454 http://www.medworm.com/index.php?rid=5355453&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2888 ConclusionThe majority of pregnant women report hypothetical interest in NIPD, primarily because of increased safety for the fetus, although a significant minority are uninterested or ambivalent. Discussions with healthcare providers regarding NIPD, and their recommendations, are likely to be an important factor in women's decisions about this testing. As such, adequate discussion of the implications of prenatal diagnostic testing will be critical. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5355453 Wed, 26 Oct 2011 04:00:00 +0100 5355453 http://www.medworm.com/index.php?rid=5355452&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2883 ConclusionPrevalence of CHD was about fourfold higher for fetuses with NT ≥ 3.5 mm (3.2%) than in the general population. This higher risk is comparable to that of other risk factors commonly used for early referral to specialized echocardiography. Nevertheless, our results, suggest that NT is not a very effective or efficient tool for the prenatal screening of CHD. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5355452 Wed, 26 Oct 2011 04:00:00 +0100 5355452 http://www.medworm.com/index.php?rid=5355451&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2890 (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5355451 Wed, 26 Oct 2011 04:00:00 +0100 5355451 http://www.medworm.com/index.php?rid=5355450&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2897 ConclusionAnalysis of published data demonstrated a pooled amniocentesis‐related loss rate of 3.5% in twin gestations < 24 weeks. Pooled loss rates within other post‐amniocentesis intervals or other gestational age windows and the impact of chorionicity on procedure‐related loss rates cannot be determined from published data. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5355450 Wed, 26 Oct 2011 04:00:00 +0100 5355450 http://www.medworm.com/index.php?rid=5355449&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2880 ConclusionAlthough many parents of children with intellectual disabilities believe they would desire information regarding their fetus in a future pregnancy, most feel they would not opt to terminate their pregnancy. As new tests for intellectual disabilities become available, determining what would be most useful to prospective parents should become a high priority. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5355449 Wed, 26 Oct 2011 04:00:00 +0100 5355449 http://www.medworm.com/index.php?rid=5355448&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2896 (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5355448 Wed, 26 Oct 2011 04:00:00 +0100 5355448 http://www.medworm.com/index.php?rid=5355447&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2892 ConclusionThere is a positive trend to use cff‐DNA in maternal plasma for prenatal diagnosis of homozygous alpha‐thalassemia‐1. With this technique, invasive prenatal testing and complications can be avoided in 79.2% of unaffected fetuses. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5355447 Wed, 26 Oct 2011 04:00:00 +0100 5355447 http://www.medworm.com/index.php?rid=5355446&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2891 ConclusionAlthough performance of post hoc analysis of 3D volumes is best when carried out from a profile starting section and quicker than two‐dimensional analysis, it appears to be not ready for clinical use because nuchal translucency could not be examined in 10% of the fetuses. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5355446 Wed, 26 Oct 2011 04:00:00 +0100 5355446 http://www.medworm.com/index.php?rid=5355445&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2870 ConclusionsThe reference range of fetal thigh volume was determined by 3D‐ultrasound using the XI VOCAL method. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5355445 Wed, 26 Oct 2011 04:00:00 +0100 5355445 http://www.medworm.com/index.php?rid=5355444&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2877 (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5355444 Wed, 26 Oct 2011 04:00:00 +0100 5355444 http://www.medworm.com/index.php?rid=5355443&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2886 (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5355443 Wed, 26 Oct 2011 04:00:00 +0100 5355443 http://www.medworm.com/index.php?rid=5355442&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2898 ConclusionOur patients suggest that connective tissue diseases or heterotaxy may be important risk factors for the development of severe cervical scoliosis. There were no significant long‐term complications directly related to cervical scoliosis. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5355442 Wed, 26 Oct 2011 04:00:00 +0100 5355442 http://www.medworm.com/index.php?rid=5343602&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2878 (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5343602 Mon, 24 Oct 2011 05:04:14 +0100 5343602 http://www.medworm.com/index.php?rid=5343601&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2776 (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5343601 Mon, 24 Oct 2011 05:04:12 +0100 5343601 http://www.medworm.com/index.php?rid=5343600&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2853 Abstract: Author's response to letter by Bogers et al. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5343600 Mon, 24 Oct 2011 05:04:11 +0100 5343600 http://www.medworm.com/index.php?rid=5343599&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2773 (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5343599 Mon, 24 Oct 2011 05:04:10 +0100 5343599 http://www.medworm.com/index.php?rid=5343598&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2874 ConclusionMaternal serum homocysteine level is increased in 11 to 14 weeks of gestation that is complicated with pre‐eclampsia, gestational hypertension, intrauterine growth restriction and preterm birth. Addition of homocysteine determination to uterine artery Doppler in the first trimester does not add any advantage in predicting adverse perinatal outcome. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5343598 Mon, 24 Oct 2011 05:03:37 +0100 5343598 http://www.medworm.com/index.php?rid=5355471&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2858 ConclusionLow PAPP‐A and free β‐hCG were significantly associated with admission to NICU and neonatal disease, independently from what could be expected because of preterm delivery or low birth weight. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5355471 Mon, 24 Oct 2011 04:00:00 +0100 5355471 http://www.medworm.com/index.php?rid=5355470&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2864 (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5355470 Mon, 24 Oct 2011 04:00:00 +0100 5355470 http://www.medworm.com/index.php?rid=5355469&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2861 ConclusionThese findings indicate the possibility of using cff DNA from amniotic fluid supernatant for array CGH with excellent results, even in late pregnancy when culture is no longer available. In this small series, pathogenic copy number variations are detected more often in the presence of IUGR than with polymalformation. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5355469 Mon, 24 Oct 2011 04:00:00 +0100 5355469 http://www.medworm.com/index.php?rid=5355468&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2856 ConclusionNot all single‐gene disorders are associated with enlarged NT, therefore NT cannot be regarded as a generic marker for single‐gene disorder but only for a limited number of these conditions. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5355468 Mon, 24 Oct 2011 04:00:00 +0100 5355468 http://www.medworm.com/index.php?rid=5355467&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2862 ConclusionIn our study, the application of microarray analysis in prenatal testing proved to be a valuable tool for the identification of submicroscopic chromosomal aberrations where conventional cytogenetic methods failed. Selection of appropriate resolution was found to be critical to obtain reliable, diagnostically conclusive data. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5355467 Mon, 24 Oct 2011 04:00:00 +0100 5355467 http://www.medworm.com/index.php?rid=5355466&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2863 ConclusionA high DR (94%) for isolated NTD was observed in the city of Barcelona. The single significant change across the study period was an increase in the first trimester DR for anencephaly (from 16% to 71%). Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5355466 Mon, 24 Oct 2011 04:00:00 +0100 5355466 http://www.medworm.com/index.php?rid=5355465&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2865 ConclusionFetuses with SCT undergoing in utero intervention have worse prognostic features, yet their neonatal outcome is similar to those of fetuses not requiring intervention. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5355465 Mon, 24 Oct 2011 04:00:00 +0100 5355465 http://www.medworm.com/index.php?rid=5355464&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2859 ConclusionsThe IFI in fetuses of diabetic mothers is lower than in fetuses of nondiabetic mothers, possibly as a result of a decreased left ventricular compliance. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5355464 Mon, 24 Oct 2011 04:00:00 +0100 5355464 http://www.medworm.com/index.php?rid=5355463&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2860 ConclusionLeft atrial shortening fraction is higher during respiratory movements as a result of increased left ventricular compliance and consequent optimization of left atrial functional status. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5355463 Mon, 24 Oct 2011 04:00:00 +0100 5355463 http://www.medworm.com/index.php?rid=5355462&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2857 (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5355462 Mon, 24 Oct 2011 04:00:00 +0100 5355462 http://www.medworm.com/index.php?rid=5355461&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2868 ConclusionThe automated NT measurement leads to a further standardization of the NT assessment process. Especially inexperienced operators may benefit from this tool. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5355461 Mon, 24 Oct 2011 04:00:00 +0100 5355461 http://www.medworm.com/index.php?rid=5355460&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2867 ConclusionFirst trimester aneuploidy screening generates education and decision‐making benchmarks for patients and providers. It is important to address these barriers as this new screen becomes a growing part of current prenatal genetic testing offerings. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5355460 Mon, 24 Oct 2011 04:00:00 +0100 5355460 http://www.medworm.com/index.php?rid=5355459&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2869 ConclusionIntracranial translucency and CM can be measured reliably at the 11 to 14 weeks examination and the measurements are highly reproducible. IT appears to be increased in fetuses with chromosomal abnormalities. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5355459 Mon, 24 Oct 2011 04:00:00 +0100 5355459 http://www.medworm.com/index.php?rid=5355458&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2872 (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5355458 Mon, 24 Oct 2011 04:00:00 +0100 5355458 http://www.medworm.com/index.php?rid=5355457&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2873 ConclusionFCT is effective in women <36 and ≥36 years. The balance between FPR and DR is more favourable in women <36 years with comparable OAPR. Although FPR increases with increasing maternal age, performance of FCT in AMA women is more effective than screening based on maternal age alone. Lowering the cut‐off to 1:100 in AMA women is suggested to improve screening performance. Routinely offering diagnostic testing to AMA women as a screening policy for the detection of DS seems not reasonable. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5355457 Mon, 24 Oct 2011 04:00:00 +0100 5355457 http://www.medworm.com/index.php?rid=5330870&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2849 ConclusionSome of the multivariable models drawn from the literature accurately predicted the late PE occurrence. The failure of some models may be because of the population in question not bearing several of the risk factors used to generate the models proposed. An effective combined screening at first trimester for late PE seems possible. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5330870 Sat, 01 Oct 2011 04:00:00 +0100 5330870 http://www.medworm.com/index.php?rid=5217742&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2839 ConclusionsMRI measurements of fetal lung volumes, liver position and side of the defect correlate well with neonatal survival in fetuses with isolated CDH. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5217742 Wed, 14 Sep 2011 04:00:00 +0100 5217742 http://www.medworm.com/index.php?rid=5217741&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2838 ConclusionsffDNA does not increase the accuracy of short cervix at between 22 and 24 weeks for the prediction of preterm labour. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5217741 Wed, 14 Sep 2011 04:00:00 +0100 5217741 http://www.medworm.com/index.php?rid=5204328&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2843 ConclusionConjoined twin pregnancies should be referred to tertiary centers for detailed fetal anomaly and echocardiographic assessment to evaluate prognosis and determine the possibility of postnatal surgical separation. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5204328 Thu, 08 Sep 2011 04:00:00 +0100 5204328 http://www.medworm.com/index.php?rid=5204327&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2840 ConclusionsWe provide nomograms for the ultrasonographic dimensions of the fetal CC that allows for prenatal diagnosis of abnormal dimensions of CC. The significance of abnormal CC growth in growth‐restricted fetuses should be further evaluated. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5204327 Thu, 08 Sep 2011 04:00:00 +0100 5204327 http://www.medworm.com/index.php?rid=5204326&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2845 ConclusionUltrasound risk factors one week after surgery included severe intrauterine growth restrictions and effusions in the donor twins. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5204326 Thu, 08 Sep 2011 04:00:00 +0100 5204326 http://www.medworm.com/index.php?rid=5204329&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2844 ConclusionThe postnatal outcome of fetuses with ToF may be established using PVPSV from the mid‐second trimester. This may be useful in providing the most appropriate perinatal management and accurate parental counselling. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5204329 Tue, 06 Sep 2011 04:00:00 +0100 5204329 http://www.medworm.com/index.php?rid=5194791&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2846 (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5194791 Sun, 04 Sep 2011 23:00:00 +0100 5194791 http://www.medworm.com/index.php?rid=5257332&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2854 ConclusionWe established measurements of the length of fetal corpus spongiosum and a correlation between the former and the penile length. These references can be useful when fetal genital anomalies are suspected. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5257332 Thu, 01 Sep 2011 04:00:00 +0100 5257332 http://www.medworm.com/index.php?rid=5246434&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2850 ConclusionsWe anticipate this list can serve in prioritization of future experimental studies on serum biomarkers for early onset PE. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5246434 Thu, 01 Sep 2011 04:00:00 +0100 5246434 http://www.medworm.com/index.php?rid=5217740&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2847 ConclusionsReferral indications for fetal echocardiography were appropriate (almost 50% had cardiac pathology). The mortality was high. Fetal outcome and TOP decisions correlated with CHD severity and presence of noncardiac defects. An increased NT is a strong marker for CHDs. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5217740 Thu, 01 Sep 2011 04:00:00 +0100 5217740 http://www.medworm.com/index.php?rid=5204325&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2837 (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5204325 Thu, 01 Sep 2011 04:00:00 +0100 5204325 http://www.medworm.com/index.php?rid=5194790&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2841 (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5194790 Wed, 31 Aug 2011 23:00:00 +0100 5194790 http://www.medworm.com/index.php?rid=5155793&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2789 (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5155793 Thu, 25 Aug 2011 08:20:51 +0100 5155793 http://www.medworm.com/index.php?rid=5155792&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2774 (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5155792 Thu, 25 Aug 2011 08:20:50 +0100 5155792 http://www.medworm.com/index.php?rid=5155791&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2753 (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5155791 Thu, 25 Aug 2011 08:20:48 +0100 5155791 http://www.medworm.com/index.php?rid=5094355&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2820 ConclusionsFurther research on the new direct access method of referral is required, as it may have a role in the uptake of prenatal screening for Down syndrome. More time is needed to show a definitive effect. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5094355 Mon, 01 Aug 2011 23:00:00 +0100 5094355 http://www.medworm.com/index.php?rid=5094354&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2762 ConclusionsUltrasound findings suspicious for toxoplasma and CMV infection are not pathognomonic for either pathologic entity. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5094354 Sun, 31 Jul 2011 23:00:00 +0100 5094354 http://www.medworm.com/index.php?rid=5076428&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2836 ConclusionsIntegrated, sequential, and contingent screenings are all more efficacious than the combined test. Overall, the contingent approach was the most efficient with a high‐detection rate, the lowest FPR, and the least amount of testing. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5076428 Sat, 30 Jul 2011 01:43:46 +0100 5076428 http://www.medworm.com/index.php?rid=5076433&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2829 ConclusionTTD is a multisystem disease that predisposes mothers of affected patients to substantial risks for pregnancy complications and TTD neonates have a high incidence of multiple abnormalities. Published 2011. This article is a U.S. Government work and is in the public domain in the USA (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5076433 Thu, 28 Jul 2011 23:00:00 +0100 5076433 http://www.medworm.com/index.php?rid=5076432&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2830 (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5076432 Thu, 28 Jul 2011 23:00:00 +0100 5076432 http://www.medworm.com/index.php?rid=5076431&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2831 ConclusionsFirst‐trimester assessment of the fetal heart is feasible in a low‐risk population when performed by experienced obstetricians. However, although most types of CHD can be diagnosed early in pregnancy, some may become apparent later in gestation. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5076431 Thu, 28 Jul 2011 23:00:00 +0100 5076431 http://www.medworm.com/index.php?rid=5076430&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2832 (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5076430 Thu, 28 Jul 2011 23:00:00 +0100 5076430 http://www.medworm.com/index.php?rid=5076429&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2833 ConclusionsPlacenta lacunae and lack of a clear zone are frequently observed in placenta previa even when there is no adherence of the placenta. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5076429 Thu, 28 Jul 2011 23:00:00 +0100 5076429 http://www.medworm.com/index.php?rid=5068590&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2835 ConclusionPreliminary assessment indicates uncertainty among obstetric providers about the details of implementing cell‐free fetal DNA testing and suggests expanded research on perspectives of this stakeholder group. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5068590 Wed, 27 Jul 2011 15:42:37 +0100 5068590 http://www.medworm.com/index.php?rid=5061535&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2834 ConclusionImmediate complications following cordocentesis are significantly higher in twin pregnancies, but fetal loss rate within 2 weeks of the procedure is comparable. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5061535 Mon, 25 Jul 2011 19:38:18 +0100 5061535 http://www.medworm.com/index.php?rid=5061536&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2783 ConclusionsOur findings suggest that the majority of DS fetuses have smaller thymuses than control. Prenatal measurements of the thymus may be clinically useful in the management of DS pregnancies. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5061536 Sat, 23 Jul 2011 23:00:00 +0100 5061536 http://www.medworm.com/index.php?rid=5048370&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2828 (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5048370 Fri, 22 Jul 2011 00:01:45 +0100 5048370 http://www.medworm.com/index.php?rid=5048369&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2814 ConclusionsThere is higher ffDNA concentration in multiple pregnancies, and this must be taken into account for future quantitative ffDNA applications. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5048369 Fri, 22 Jul 2011 00:01:20 +0100 5048369 http://www.medworm.com/index.php?rid=5026909&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2826 ConclusionThis retrospective study of placental mosaicism in CVS is the largest single centre study to date and provides a figure for the occurrence of completely discrepant results between QF–PCR and karyotype due to placental mosaicism. This study also demonstrates that the presence of triallelic peaks at QF–PCR is not sufficient to exclude the presence of placental mosaicism. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5026909 Wed, 13 Jul 2011 23:00:00 +0100 5026909 http://www.medworm.com/index.php?rid=5018035&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2804 ConclusionsAbnormal prenatal findings are frequent in NS pregnancies, though they are not specific and most are not useful for the prediction of the postnatal phenotype. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5018035 Sun, 10 Jul 2011 23:00:00 +0100 5018035 http://www.medworm.com/index.php?rid=5018034&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2818 ConclusionFollowing successful laser surgery for TTTS, an increased and comparable postnatal prevalence of CHD occurs among both former recipients and donors. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5018034 Sun, 10 Jul 2011 23:00:00 +0100 5018034 http://www.medworm.com/index.php?rid=5018033&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2821 (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5018033 Sun, 10 Jul 2011 23:00:00 +0100 5018033 http://www.medworm.com/index.php?rid=5018031&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2822 ConclusionOur findings suggest a potential role for first‐trimester metabolomics in screening for PE. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5018031 Sun, 10 Jul 2011 23:00:00 +0100 5018031 http://www.medworm.com/index.php?rid=5018030&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2823 ConclusionBPD in the first half of pregnancy is related to fetal size at term and risk of PTL. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5018030 Sun, 10 Jul 2011 23:00:00 +0100 5018030 http://www.medworm.com/index.php?rid=5018029&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2824 ConclusionIn cases of urinary tract malformation, this work confirms the need for regular and frequent ultrasound scans, checking for the echographic factors indicative of gravity and for adapted karyotyping. It also demonstrates that pluridisciplinary management is necessary for the prenatal evaluation of renal and overall fetal prognosis. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5018029 Sun, 10 Jul 2011 23:00:00 +0100 5018029 http://www.medworm.com/index.php?rid=5018028&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2825 ConclusionOur study suggests that women differentiate between various decision‐making actors depending on the type of pregnancy termination. The differences observed between 1999 and 2005 suggest a strong interaction between women's experiences, legislation and practices. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5018028 Sun, 10 Jul 2011 23:00:00 +0100 5018028 http://www.medworm.com/index.php?rid=5006406&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2816 (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5006406 Mon, 04 Jul 2011 23:00:00 +0100 5006406 http://www.medworm.com/index.php?rid=5026908&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2827 ConclusionThe prognosis of early onset renal oligohydramnios is poor. Predictive determinants of survival are: GA at diagnosis, nature of renal anomaly (hydronephrosis vs other), and presence of associated anomalies. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5026908 Thu, 30 Jun 2011 23:00:00 +0100 5026908 http://www.medworm.com/index.php?rid=5018027&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2819 ConclusionsThe spectrum of lesions in individuals assumed to be genetically identical and the disproportionate incidence of laterality and ventricular hypoplasia in this population leads us to propose potential mechanisms for the development of CHD in this population including local environmental or epigenetic factors influencing gene expression differentially, abnormal reciprocal laterality signaling between twinned embryos, or placental vascular factors affecting hemodynamics, either early in gestation or later in the setting of TTTS, leading to valvar lesions and ventricular hypoplasia. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5018027 Thu, 30 Jun 2011 23:00:00 +0100 5018027 http://www.medworm.com/index.php?rid=5006405&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2817 ConclusionWe describe the potential of whole‐genome placental profiling to identify small genomic imbalances, which might contribute to a small proportion of well‐characterized, unexplained stillbirths. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5006405 Thu, 30 Jun 2011 23:00:00 +0100 5006405 http://www.medworm.com/index.php?rid=4991832&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2815 ConclusionsThe maternal transmissions of alleles with 55 to 59 CGG repeats summarized here indicate that the risk for expansion to full mutation is substantially less than previous estimates for this size category. Most premutation alleles with no family history of fragile X exhibited less instability than those with a history of fragile X. Thus, lower risk estimates for full mutation expansion may be appropriate for women newly identified as premutation carriers through routine screening. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=4991832 Thu, 30 Jun 2011 23:00:00 +0100 4991832 http://www.medworm.com/index.php?rid=4991834&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2772 ConclusionWomen's appraisal of program efficacy and convenience, their disease‐related knowledge and perceived Q fever risk seem to be crucial for their intended program uptake. A successful implementation of a Q fever screening and treatment program may thus depend on the benefits and downsides of the program, and on securing that women are aware of the risks of the disease. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=4991834 Wed, 29 Jun 2011 23:00:00 +0100 4991834 http://www.medworm.com/index.php?rid=4991833&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2807 ConclusionSerum PlGF is an acceptable marker in first trimester screening for early‐onset PE, but a poor marker in screening for IUGR. Screening performance of serum PAPP‐A is poor for both early‐onset PE and IUGR. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=4991833 Wed, 29 Jun 2011 23:00:00 +0100 4991833 http://www.medworm.com/index.php?rid=4974702&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2813 (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=4974702 Tue, 28 Jun 2011 19:04:11 +0100 4974702 http://www.medworm.com/index.php?rid=4974704&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2811 ConclusionThe study provides normal ranges of NBL between 16 and 23 weeks of pregnancy in a low‐risk Turkish population. Future studies with larger sample sizes including pregnancies carrying high risk for aneuploidy are needed to define cut‐off values for NBL. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=4974704 Mon, 27 Jun 2011 23:00:00 +0100 4974704 http://www.medworm.com/index.php?rid=4974703&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2812 (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=4974703 Mon, 27 Jun 2011 23:00:00 +0100 4974703 http://www.medworm.com/index.php?rid=5094356&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2794 ConclusionsReconstructed mid‐sagittal views obtained by 3D multiplanar manipulations or by VCI‐C are valid approaches for measuring CC length. In these views the CC should be measured as the region underneath the comma‐shaped echogenic structure. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=5094356 Sun, 26 Jun 2011 23:00:00 +0100 5094356 http://www.medworm.com/index.php?rid=4974719&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2782 ConclusionPrenatal ultrasound findings in Noonan syndrome can be subtle and aspecific, but when specific characteristics are present additional targeted DNA analysis is indicated. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=4974719 Sun, 26 Jun 2011 23:00:00 +0100 4974719 http://www.medworm.com/index.php?rid=4974718&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2784 (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=4974718 Sun, 26 Jun 2011 23:00:00 +0100 4974718 http://www.medworm.com/index.php?rid=4974717&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2785 ConclusionA majority of study participants (n = 147, 60%) chose genetic screening; uptake and motivation were similar across language groups. Familiarity with genetic conditions was deficient and screening terminology confusing regardless of primary language. The perceived positive utility of printed information (S > E) highlights the importance of clear and early counseling. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=4974717 Sun, 26 Jun 2011 23:00:00 +0100 4974717 http://www.medworm.com/index.php?rid=4974716&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2786 ConclusionsPGD is a reliable method to prevent pregnancy of children affected with Hunter syndrome. In addition, derived HESC can be further utilized for drug testing and better understanding of the pathogenesis of this syndrome. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=4974716 Sun, 26 Jun 2011 23:00:00 +0100 4974716 http://www.medworm.com/index.php?rid=4974715&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2788 (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=4974715 Sun, 26 Jun 2011 23:00:00 +0100 4974715 http://www.medworm.com/index.php?rid=4974714&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2790 ConclusionOf cordocenteses performed based on accessibility and quality of visualization, cord insertion puncture may cause more maternal blood contamination but free loop puncture may be associated with more difficult procedures, while the safety was comparable. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=4974714 Sun, 26 Jun 2011 23:00:00 +0100 4974714 http://www.medworm.com/index.php?rid=4974713&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2791 ConclusionSensitivity and positive predictive value of first trimester scan to identify an isolated SUA in a prospective unselected population was poor. Diagnosis of isolated SUA as well as a definitive judgment about the presence of associated anomalies would still require a scan in the second trimester. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=4974713 Sun, 26 Jun 2011 23:00:00 +0100 4974713 http://www.medworm.com/index.php?rid=4974712&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2793 (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=4974712 Sun, 26 Jun 2011 23:00:00 +0100 4974712 http://www.medworm.com/index.php?rid=4974711&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2794 ConclusionsReconstructed mid‐sagittal views obtained by 3D multiplanar manipulations or by VCI‐C are valid approaches for measuring CC length. In these views the CC should be measured as the region underneath the comma‐shaped echogenic structure. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=4974711 Sun, 26 Jun 2011 23:00:00 +0100 4974711 http://www.medworm.com/index.php?rid=4974710&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2795 ConclusionsVentriculomegaly associated with multiple echo‐dense nodules is characteristic of severe fetal toxoplasmosis and carries a poor prognosis. When the ventricles have normal size or are only mildly dilated, the nodules restricted to the parenchyma development may be normal. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=4974710 Sun, 26 Jun 2011 23:00:00 +0100 4974710 http://www.medworm.com/index.php?rid=4974709&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2796 ConclusionsOur results showed that a definitive etiology can be established in most cases of prenatal holoprosencephaly. Chromosomal anomalies were the most frequent finding. However, in euploid fetuses, molecular diagnosis is worthwhile, as different genes with different inheritance patterns may be responsible for this malformation. Thorough evaluation proved beneficial for assessing more accurate prognosis and recurrence risks. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=4974709 Sun, 26 Jun 2011 23:00:00 +0100 4974709 http://www.medworm.com/index.php?rid=4974708&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2799 (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=4974708 Sun, 26 Jun 2011 23:00:00 +0100 4974708 http://www.medworm.com/index.php?rid=4974707&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2801 ConclusionsUterine manipulation with the transvaginal probe may be a useful solution in cases where TA‐CVS is limited by difficult access to the trophoblast. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=4974707 Sun, 26 Jun 2011 23:00:00 +0100 4974707 http://www.medworm.com/index.php?rid=4974706&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2802 ConclusionsThe DR for trisomy 21 in California's statewide quadruple‐marker screening is very similar to the Program's previously reported DR using triple‐marker screening. However, this was achieved at a lower SPR, demonstrating improved screening performance. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=4974706 Sun, 26 Jun 2011 23:00:00 +0100 4974706 http://www.medworm.com/index.php?rid=4951391&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2800 ConclusionsIn addition to FTS results, we found that genetic counseling may be an influential factor in the patient's decision regarding PDT. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=4951391 Tue, 21 Jun 2011 17:32:41 +0100 4951391 http://www.medworm.com/index.php?rid=4951401&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2763 (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=4951401 Mon, 20 Jun 2011 23:00:00 +0100 4951401 http://www.medworm.com/index.php?rid=4951400&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2764 ConclusionsChanges in prenatal screening policy significantly increased referral after screening and improved the efficacy of invasive prenatal diagnosis. We show the continuing effect of the different policies applied in the past to women below and above the age of 36. To further improve efficacy of invasive prenatal diagnosis, first trimester combination screening should be actively offered to women of all ages. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=4951400 Mon, 20 Jun 2011 23:00:00 +0100 4951400 http://www.medworm.com/index.php?rid=4951399&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2765 ConclusionTrisomy 18 is associated with adrenal gland hypoplasia which is apparent at 11–13 weeks' gestation. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=4951399 Mon, 20 Jun 2011 23:00:00 +0100 4951399 http://www.medworm.com/index.php?rid=4951398&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2766 ConclusionWe have developed an alternative to fluorescence in situ hybridization (FISH) aneuploidy screening and microarray analysis in otherwise normal pregnancies undergoing invasive testing. We demonstrated that the assay will detect all microdeletions and aneuploidies of regions covered on the assay. We developed analytical software that displays results for well‐characterized syndromes but not abnormalities of unclear clinical significance. This assay is likely to be preferred by women seeking testing beyond routine karyotyping but who desire more information than provided by aneuploidy FISH. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=4951398 Mon, 20 Jun 2011 23:00:00 +0100 4951398 http://www.medworm.com/index.php?rid=4951397&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2767 ConclusionRegarding the limited types of frequent mutations among Balouch population, it is hopefully believed that the incidence of β‐thalassemia could be controlled by a correct diagnosis in the due time. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=4951397 Mon, 20 Jun 2011 23:00:00 +0100 4951397 http://www.medworm.com/index.php?rid=4951396&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2768 ConclusionThis study demonstrates that heavy metals pass into and accumulate in AF from a very early stage of gestation. Other studies are needed to evaluate the long‐term health effects of this early exposure. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=4951396 Mon, 20 Jun 2011 23:00:00 +0100 4951396 http://www.medworm.com/index.php?rid=4951395&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2769 ConclusionsPAR recognizes that not all providers are equal, and perfection is unrealistic. Using this approach all ‘can play’ while patients are protected from poor performance. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=4951395 Mon, 20 Jun 2011 23:00:00 +0100 4951395 http://www.medworm.com/index.php?rid=4951394&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2771 ConclusionPractitioners must be aware that when forming a subjective probability assessment, pregnant women might be inappropriately sensitive to the severity of Y, and inappropriately numb to the number X, and that a simple communicative intervention can help in overcoming this selective number numbness. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=4951394 Mon, 20 Jun 2011 23:00:00 +0100 4951394 http://www.medworm.com/index.php?rid=4951393&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2775 ConclusionErroneous PAPP‐A kits resulted in an increase in the FPR by 1.2%. There were no reports of iatrogenic miscarriage. The occurrence of this problem reaffirms the importance of continuous monitoring of quality in FTS. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=4951393 Mon, 20 Jun 2011 23:00:00 +0100 4951393 http://www.medworm.com/index.php?rid=4951392&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2792 ConclusionAnalysis of free beta hCG and PAPP‐A using a dual analyte dried blood spot assay is an effective tool in Down syndrome screening, adding an important option for those considering implementation or modification of existing prenatal screening programs. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=4951392 Mon, 20 Jun 2011 23:00:00 +0100 4951392 http://www.medworm.com/index.php?rid=4932412&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2810 This article reviews the world experience in fetal cardiac interventions. In carefully selected cases, fetal cardiac surgery can reverse end‐stage heart failure and can provide biventricular outcome postnatally in about two thirds of the cases with successful interventions. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=4932412 Mon, 13 Jun 2011 23:00:00 +0100 4932412 http://www.medworm.com/index.php?rid=4932411&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2806 ConclusionA large number of infants with severe CDH surviving after FETO have a degree of tracheomegaly that is associated with the severity of CDH as assessed by pre‐FETO LHR. This tracheomegaly does not constitute an obvious clinical problem. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=4932411 Mon, 13 Jun 2011 23:00:00 +0100 4932411 http://www.medworm.com/index.php?rid=4920092&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2803 AbstractMonochorionic twins are subjected to specific complications which originate in either imbalance or abnormality of the single placenta serving two twins including twin‐to‐twin transfusion syndrome. The diagnosis is well established in overt clinical forms with the association of polyuric polyhydramnios and oliguric oligohydramnios. The best treatment of cases presenting before 26 weeks of gestion is fetoscopic laser ablation of the intertwin anastomoses on the chorionic plate. Although subjected to subtle variations, the core technique follows robust guidelines which could help understanding and acquiring the required skills and experience to perform this procedure. However appropriate and tailored hands‐on training and appropriate perinatal set‐up are critical not only for ... Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=4920092 Wed, 08 Jun 2011 23:00:00 +0100 4920092 http://www.medworm.com/index.php?rid=4920091&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2797 AbstractTwin–twin transfusion syndrome (TTTS) is a severe complication occurring in about 10% of monochorionic twin pregnancies. The chronic unbalanced transfusion of blood across placental vascular communications from the donor to the recipient twin may lead to impairment of various organ systems in the affected twins. In Hamburg, Germany, since 1995 patients with TTTS were treated with fetoscopic laser coagulation as the first causal therapeutic strategy. All survivors after laser surgery were followed up in the University Children's Hospital in Bonn, Germany. In this article, we summarize long‐term follow‐up studies from our German study population and compare our results with data from the literature. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=4920091 Wed, 08 Jun 2011 23:00:00 +0100 4920091 http://www.medworm.com/index.php?rid=4920090&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2809 (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=4920090 Wed, 08 Jun 2011 23:00:00 +0100 4920090 http://www.medworm.com/index.php?rid=4910430&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2780 AbstractWith the increased use of invasive fetal procedures, the number of women facing post‐procedure membrane rupture is increasing. Here we review the use of platelets and fresh frozen plasma for sealing iatrogenic fetal membrane defects by describing the mechanisms of action of the amniopatch procedure as well as published experience. In cases of iatrogenic preterm pre‐labour rupture of the membranes, amniopatch effectively seals the fetal membranes in over two‐thirds of cases. There is a risk of 16% of in utero fetal death, which may occur at varying intervals from the procedure and often for unknown reasons. Amniopatch has also been used as a treatment of chorionic membrane separation. In summary, current experience suggests that in cases of early onset but persistent amniotic ... Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=4910430 Tue, 07 Jun 2011 23:00:00 +0100 4910430 http://www.medworm.com/index.php?rid=4910429&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2781 AbstractSacrococcygeal teratoma (SCT) is one of the most common tumors in newborns with a birth prevalence of up to 1 in 21 700 births. Routine fetal anomaly screening programs allow for prenatal diagnosis in many cases. Fetal ultrasound with Doppler evaluation and more recently magnetic resonance imaging may be used to document the extent of the tumor as well as identifying the population at risk for serious fetal complications. Rapidly growing SCT and highly vascularized tumors are more likely to have hemodynamic repercussions. Fetal hydrops is usually considered as a poor prognostic marker and a potential indicator for fetal intervention. Newborns with SCT require stabilization prior to early surgical resection. In case of malignancy additional chemotherapy may be required. SCT may resu... Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=4910429 Tue, 07 Jun 2011 23:00:00 +0100 4910429 http://www.medworm.com/index.php?rid=4932410&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2798 (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=4932410 Tue, 31 May 2011 23:00:00 +0100 4932410 http://www.medworm.com/index.php?rid=4920089&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2808 AbstractProgress in prenatal diagnosis can lead to the diagnosis of severe fetal abnormalities for which natural history anticipates a fatal outcome or the development of severe disability despite optimal postnatal care. Intrauterine therapy can be offered in these selected cases. Prenatal diagnosis is the only field of medicine in which termination is an option in the management of severe diseases. Fetal therapy has therefore developed as an alternative to fatalist expectant prenatal management as well as to termination of pregnancy (TOP). There are few standards of fetal care that have gone beyond the stage of equipoise and even fewer have been established based on appropriate studies comparing pre‐ and postnatal care. Several ethical questions are being raised as fetal surgery develop... Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=4920089 Tue, 31 May 2011 23:00:00 +0100 4920089 http://www.medworm.com/index.php?rid=4910428&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2805 AbstractDespite efforts at prevention through the use of preconception folic acid, spina bifida remains one of the most common congenital anomalies of the central nervous system that is compatible with life. It is, however, associated with a significant degree of lifelong morbidity. The development of open fetal surgery for myelomeningocele (MMC) has been a long process but one that serves as a model for how new procedures and technologies need to be properly evaluated before being brought into mainstream medical practice. Even so, risks and benefits need to be evaluated for each patient. The currently available studies have been carried out on a highly selected patient population where the fetal findings provided the maximum opportunity for benefit from prenatal closure of the MMC defect.... Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=4910428 Tue, 31 May 2011 23:00:00 +0100 4910428 http://www.medworm.com/index.php?rid=4891629&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2777 AbstractFetal therapy can be defined as any prenatal treatment administered to the mother with the primary indication to improve perinatal or long‐term outcomes for the fetus or newborn. This review provides an update of the pharmacological therapies that are solely directed at the fetus with anomalies and outlines a future transcriptomic approach. Fetal anomalies targeted with prenatal pharmacotherapy are a heterogeneous group of structural, endocrine, and metabolic conditions, including congenital cystic adenomatoid malformation (CCAM), congenital adrenal hyperplasia, congenital heart block, fetal tachyarrhythmias, inborn errors of metabolism, fetal thyroid disorders, and polyhydramnios. To date, the majority of pharmacotherapies for fetal anomalies have been evaluated only in retrospe... Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=4891629 Tue, 31 May 2011 23:00:00 +0100 4891629 http://www.medworm.com/index.php?rid=4882748&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2770 ConclusionFetal RHD genotyping can accurately be determined using ccff DNA in the first and second trimesters of pregnancy. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=4882748 Tue, 31 May 2011 23:00:00 +0100 4882748 http://www.medworm.com/index.php?rid=4870742&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2779 AbstractFetal and neonatal alloimmune thrombocytopenia (FNAIT) is a potentially devastating condition, which may lead to intracranial haemorrhage (ICH) in the fetus or neonate, often with death or major neurological damage as consequence. In the absence of screening, preventive measures are only possible in the next pregnancy of women with an affected child. Controversy exists on the best intervention to minimise the risk of ICH. Most centres have abandoned treatment with serial fetal blood sampling (FBS) and platelet transfusions, because of a high rate of complications and the availability of quite effective non‐invasive alternatives. In pregnancies with FNAIT and a previous affected child without ICH, weekly intravenous administration of immunoglobulins to the mother appears close to ... Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=4870742 Fri, 27 May 2011 22:51:49 +0100 4870742 http://www.medworm.com/index.php?rid=4870744&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2778 AbstractThe widespread availability of high resolution ultrasound equipment and almost universal routine anatomy scanning in all pregnant women in the developed world has lead to increased detection of abnormalities in the fetal thorax. Already in the 1980s, large pleural effusions and significant macrocystic lesions in the fetus were easily detected on ultrasound. However, smaller lung tumours were often missed. Nowadays, fetal medicine centres receive many referrals for evaluation of fetal lung lesions, of which the most common are congenital cystic adenomatoid malformation and bronchopulmonary sequestration. Almost invariably, both the parents and the referring physicians experience anxiety after detection of large lung masses in the fetus. However, the vast majority of the currently de... Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=4870744 Tue, 24 May 2011 23:00:00 +0100 4870744 http://www.medworm.com/index.php?rid=4870743&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2787 AbstractPrenatal gene therapy aims to deliver genes to cells and tissues early in prenatal life, allowing correction of a genetic defect, before long‐term tissue damage has occurred. In contrast to postnatal gene therapy, prenatal application can target genes to a large population of dividing stem cells, and the smaller fetal size allows a higher vector‐to‐target cell ratio to be achieved. Early‐gestation delivery may allow the development of immune tolerance to the transgenic protein which would facilitate postnatal repeat vector administration if needed.Targeting particular organs will depend on manipulating the vector to achieve selective tropism and on choosing the most appropriate gestational age and injection method for fetal delivery. Intra‐amniotic injection reaches the s... Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=4870743 Tue, 24 May 2011 23:00:00 +0100 4870743 http://www.medworm.com/index.php?rid=4852326&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2730 (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=4852326 Mon, 23 May 2011 16:20:23 +0100 4852326 http://www.medworm.com/index.php?rid=4703645&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2732 (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=4703645 Sun, 10 Apr 2011 23:00:00 +0100 4703645 http://www.medworm.com/index.php?rid=4703644&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2755 ConclusionSmoking leads to increased screen positive rates, especially for trisomy 18 using combined or integrated tests. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=4703644 Sun, 10 Apr 2011 23:00:00 +0100 4703644 http://www.medworm.com/index.php?rid=4703643&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2756 ConclusionThe solution adopted for fetoscopic endoluminal tracheal occlusion (FETO) is justified by the extended period of time it has been available to patients before the start of the RCT. Strong patient and referring physician preferences do not entail a right to have FETO, since it is a procedure of yet unproven efficacy and safety. In the future, to avoid the dilemmas posed by the TM and in name of the right of future generations of patients to have access to treatment of proven safety and efficacy, researchers must be able to plan RCT in due time. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=4703643 Sun, 10 Apr 2011 23:00:00 +0100 4703643 http://www.medworm.com/index.php?rid=4703642&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2757 ConclusionFindings should provide reassurance to practitioners and parents that isolated CPCs in fetuses with normal karyotypes do not affect child development after birth. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=4703642 Sun, 10 Apr 2011 23:00:00 +0100 4703642 http://www.medworm.com/index.php?rid=4703641&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2758 ConclusionSpontaneous responding to prenatal follow‐up questionnaires is significantly biased towards older and nonsmoking mothers with normal pregnancy outcome. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=4703641 Sun, 10 Apr 2011 23:00:00 +0100 4703641 http://www.medworm.com/index.php?rid=4703640&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2759 ConclusionResults demonstrate the utility of a simple FISH panel in increasing the detection rate of abnormal karyotypes. They also reveal the high frequency of overgrowth of maternal cells in cultured specimens from villi after embryonic loss. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=4703640 Sun, 10 Apr 2011 23:00:00 +0100 4703640 http://www.medworm.com/index.php?rid=4703639&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2760 ConclusionsThe SFRV values in fetuses with trisomy 21 appear to be significantly greater than in the euploid fetuses. The RVDD also appears to be greater in fetuses with trisomy 21 than in the euploid fetuses. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=4703639 Sun, 10 Apr 2011 23:00:00 +0100 4703639 http://www.medworm.com/index.php?rid=4703638&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2761 (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=4703638 Thu, 31 Mar 2011 23:00:00 +0100 4703638 http://www.medworm.com/index.php?rid=4682984&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2754 (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=4682984 Thu, 31 Mar 2011 23:00:00 +0100 4682984 http://www.medworm.com/index.php?rid=4652038&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2750 ConclusionsOur data represent the largest published series involving this type of genomic analysis in routine prenatal diagnosis, without indication bias. The panel increases significantly the diagnostic yield of conventional PCD and does not pose interpretation problems. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=4652038 Wed, 30 Mar 2011 03:42:51 +0100 4652038 http://www.medworm.com/index.php?rid=4641759&cid=s_33682_69_f&fid=33682&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpd.2752 (Source: Prenatal Diagnosis) Prenatal Diagnosis journals http://www.medworm.com/rss/comments.php?id=4641759 Mon, 28 Mar 2011 17:09:53 +0100 4641759