MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Psychopharmacology' source. Tue, 07 Feb 2012 09:36:01 +0100 http://www.medworm.com/index.php?rid=5665217&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fkgp2t07h6145u754%2F Conclusions  Overall, the results suggest that long-term ecstasy exposure may induce a deficit in associative learning and this may be in part a consequence of users adopting a more liberal decision criterion value. Content Type Journal ArticleCategory Original InvestigationPages 1-13DOI 10.1007/s00213-012-2652-xAuthors Denis T. Gallagher, School of Psychology, University of Central Lancashire, Darwin Building, Preston, Lancashire PR1 2HE, UKJohn E. Fisk, School of Psychology, University of Central Lancashire, Darwin Building, Preston, Lancashire PR1 2HE, UKCatharine Montgomery, Liverpool John Moores University, Liverpool, L3 3AF UKJeannie Judge, School of Psychology, University of Central Lancashire, Darwin Building, Preston, Lancashire PR1 2HE, UKSarita J. Robinson,... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5665217 Fri, 03 Feb 2012 07:19:30 +0100 5665217 http://www.medworm.com/index.php?rid=5658052&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd3277q7141p62t28%2F Conclusions  The continuing effectiveness of sazetidine-A in reducing nicotine self-administration in both male and female rats supports its promise as a new treatment to help people successfully quit smoking. Content Type Journal ArticleCategory Original InvestigationPages 1-8DOI 10.1007/s00213-012-2642-zAuthors Joshua E. Johnson, Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 104790, Durham, NC 27710, USASusan Slade, Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 104790, Durham, NC 27710, USACorinne Wells, Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 104790, Durham, NC 27710, USAAnn Petro, Department of Psychiatry and Behavioral Sciences, Duke Unive... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5658052 Wed, 01 Feb 2012 17:14:21 +0100 5658052 http://www.medworm.com/index.php?rid=5658053&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F76r4r87141k05733%2F Conclusions  Prenatal immune activation enhances drug-induced reinstatement of conditioned place preference. These data demonstrate longstanding impact on behaviors with potential influence on risk for drug relapse as a consequence of prenatal immune activation. Further study is needed to determine clinical and epidemiological consequences of similar exposures in human populations. Content Type Journal ArticleCategory Original InvestigationPages 1-12DOI 10.1007/s00213-012-2646-8Authors Neil M. Richtand, Psychiatry Service (V116A), Cincinnati Veterans Affairs Medical Center, 3200 Vine Street, Cincinnati, OH 45220, USARebecca Ahlbrand, Psychiatry Service (V116A), Cincinnati Veterans Affairs Medical Center, 3200 Vine Street, Cincinnati, OH 45220, USAPaul S. Horn, Psychi... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5658053 Tue, 31 Jan 2012 07:11:29 +0100 5658053 http://www.medworm.com/index.php?rid=5645227&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe26w2lr077084218%2F Conclusions  Similar to findings following recovery from depression, LD-ATD can reduce specificity of AMT in the absence of lowered mood in healthy individuals with a strong family history of depression. These findings may reflect a 5-HT-dependent cognitive vulnerability to depression in different populations and warrant further research. Content Type Journal ArticleCategory Original InvestigationPages 1-8DOI 10.1007/s00213-012-2644-xAuthors Hamid A. Alhaj, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UKMatthew Selman, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UKVictoria Jervis, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UKJacqui Rodgers, Institute of Neuroscience, Newcastle University, N... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5645227 Fri, 27 Jan 2012 17:54:23 +0100 5645227 http://www.medworm.com/index.php?rid=5645228&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Flv402417658lk175%2F Conclusions  Implicit and explicit drinking motivations are differentially associated with problem drinking behaviors. Future research should examine the underlying neurobiological mechanisms associated with these factors. Content Type Journal ArticleCategory Original InvestigationPages 1-8DOI 10.1007/s00213-011-2613-9Authors Laura C. Herschl, Department of Psychology, 238 Burnett Hall, University of Nebraska-Lincoln, Lincoln, NE 68588-0308, USADennis E. McChargue, Department of Psychology, 238 Burnett Hall, University of Nebraska-Lincoln, Lincoln, NE 68588-0308, USAJames MacKillop, Department of Psychology, Psychology Building, University of Georgia, Athens, GA 30602-3013, USAScott F. Stoltenberg, Department of Psychology, 238 Burnett Hall, University of Nebraska-Lin... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5645228 Thu, 26 Jan 2012 16:43:11 +0100 5645228 http://www.medworm.com/index.php?rid=5645230&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fcv01lh7115742633%2F Conclusions  The shift in the ability to correctly read socioemotional information toward stimuli associated with positive emotional valence, together with the prosocial feelings elicited by MDMA, may enhance social approach behavior and sociability when MDMA is used recreationally and facilitate therapeutic relationships in MDMA-assisted psychotherapeutic settings. Content Type Journal ArticleCategory Original InvestigationPages 1-10DOI 10.1007/s00213-012-2645-9Authors Cédric M. Hysek, Division of Clinical Pharmacology and Toxicology, Department of Biomedicine and Department of Internal Medicine, University Hospital and University of Basel, Basel, SwitzerlandGregor Domes, Laboratory for Biological and Personality Psychology, Department of Psychology, University of ... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5645230 Thu, 26 Jan 2012 06:55:52 +0100 5645230 http://www.medworm.com/index.php?rid=5645229&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F53279x1m6qp17708%2F Abstract Rationale  A between-session progressive ratio (BtwPR) procedure was tested in rats responding for cocaine and water reinforcers. Objectives  Experiment 1 evaluated the sensitivity of the BtwPR procedure to the magnitude of cocaine and water reinforcers. Experiment 2 compared BtwPR performance to within-session progressive ratio (WinPR) performance. Methods  In experiment 1, rats were tested on a BtwPR procedure with three doses of cocaine (0.1, 0.3, and 1.0 mg/kg/inf) or volumes of water (0.01, 0.03, and 0.1 mL/reinforcer). BtwPR test sessions began with a seeking phase, during which the animal is required to complete a fixed ratio in order to initiate a 2-h consumption phase, where the reinforcer was available according... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5645229 Thu, 26 Jan 2012 06:55:52 +0100 5645229 http://www.medworm.com/index.php?rid=5636908&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F5563t2jk06758810%2F Conclusion  Our findings suggest that BDNF may be involved in the pathophysiology of schizophrenia, and its associated cognitive impairment, especially immediate memory. Content Type Journal ArticleCategory Original InvestigationPages 1-8DOI 10.1007/s00213-012-2643-yAuthors Xiang Yang Zhang, Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USAJun Liang, Institute of Mental Health, Peking University, Beijing, 100083 People’s Republic of ChinaDa Chun Chen, Beijing HuiLongGuan Hospital, Beijing, 100096 People’s Republic of ChinaMei Hong Xiu, Beijing HuiLongGuan Hospital, Beijing, 100096 People’s Republic of ChinaFu De Yang, Beijing HuiLongGuan Hospital, Beijing, 100096 People’s Republic of ChinaTherese A. Kosten... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5636908 Wed, 25 Jan 2012 06:52:38 +0100 5636908 http://www.medworm.com/index.php?rid=5636909&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn52075238808q5x6%2F Conclusions  We conclude that sustained attention displays an inverse U-shaped dependence on NT, mediated—at least in part—by α2- and β-adrenoceptors. We speculate that low doses of NT improve performance by maximizing the phasic release of NE, while higher doses of NT would elevate tonic levels of NE, thus producing suboptimal levels of phasically released NE. Content Type Journal ArticleCategory Original InvestigationPages 1-9DOI 10.1007/s00213-012-2635-yAuthors Swagata Roychowdhury, Laboratory of Synaptic and Cellular Physiology, School of Behavioral and Brain Sciences, University of Texas at Dallas/GR41, 800 West Campbell Road, Richardson, TX 75080, USAZulma Peña-Contreras, Laboratory of Synaptic and Cellular Physiology, School of Behavioral and Brain Scien... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5636909 Tue, 24 Jan 2012 06:49:38 +0100 5636909 http://www.medworm.com/index.php?rid=5626410&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb3709432x6035551%2F Conclusion  Only acute methadone impaired accuracy and/or performance on three tests of memory retrieval. These findings in rats suggest that memory deficits reported in methadone-maintained individuals may not be directly attributable to methadone. Content Type Journal ArticleCategory Original InvestigationPages 1-11DOI 10.1007/s00213-012-2638-8Authors Erin Cummins, Department of Psychology, University of Guelph, Guelph, N1G 2W1 Ontario, CanadaCraig P. Allen, Department of Psychology, University of Guelph, Guelph, N1G 2W1 Ontario, CanadaAlexander Ricchetti, Department of Psychology, University of Guelph, Guelph, N1G 2W1 Ontario, CanadaEmily Boughner, Department of Psychology, University of Guelph, Guelph, N1G 2W1 Ontario, CanadaKayla Christenson, Department of Psycho... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5626410 Thu, 19 Jan 2012 08:04:39 +0100 5626410 http://www.medworm.com/index.php?rid=5626411&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft2327vk72845535r%2F Content Type Journal ArticleCategory ErratumPages 1-1DOI 10.1007/s00213-011-2631-7Authors Margarita Moreno, Departamento de Neurociencia y Ciencias de la Salud, Universidad de Almería, Carretera de Sacramento s/n, La Cañada de San Urbano, 04120 Almería, SpainValeria Edith Gutiérrez-Ferre, Departamento de Neurociencia y Ciencias de la Salud, Universidad de Almería, Carretera de Sacramento s/n, La Cañada de San Urbano, 04120 Almería, SpainLuis Ruedas, Departamento de Neurociencia y Ciencias de la Salud, Universidad de Almería, Carretera de Sacramento s/n, La Cañada de San Urbano, 04120 Almería, SpainLeticia Campa, Instituto de Investigaciones Biomédicas de Barcelona, IIBB-CSIC-IDIBAPS, CIBERESP (CS), CIBERSAM (LC), Barcelona, SpainCristina Suñol, Instituto de Investigaciones ... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5626411 Thu, 19 Jan 2012 08:04:38 +0100 5626411 http://www.medworm.com/index.php?rid=5618363&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fgx46n58459608272%2F Conclusion  The observation that yohimbine can enhance reacquisition of oxycodone seeking supports the hypothesis that stress can facilitate learning processes involved in the unfolding of relapse. Content Type Journal ArticleCategory Original InvestigationPages 1-9DOI 10.1007/s00213-012-2640-1Authors Amanda T. Campbell, Department of Psychology, University of Guelph, 50 Stone Rd. E, Guelph, ON N1W 2G1, CanadaDaniela Kwiatkowski, Department of Psychology, University of Guelph, 50 Stone Rd. E, Guelph, ON N1W 2G1, CanadaEmily Boughner, Department of Psychology, University of Guelph, 50 Stone Rd. E, Guelph, ON N1W 2G1, CanadaFrancesco Leri, Department of Psychology, University of Guelph, 50 Stone Rd. E, Guelph, ON N1W 2G1, Canada Journal PsychopharmacologyOnline I... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5618363 Tue, 17 Jan 2012 07:14:20 +0100 5618363 http://www.medworm.com/index.php?rid=5618364&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F05052p5105604l24%2F Conclusions  Ro 64-6198 produced marked anxiolytic-like effects in response to a variety of mild to strong anxiogenic stimuli, whereas it did not facilitate depression-related behaviors. This data extend previous literature suggesting that NOP receptors are a viable target for the treatment of anxiety disorders. Content Type Journal ArticleCategory Original InvestigationPages 1-12DOI 10.1007/s00213-012-2636-xAuthors Celia Goeldner, CNS Research, CNS Discovery, pRED, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, CH-4070 Basel, SwitzerlandWill Spooren, CNS Research, CNS Discovery, pRED, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, CH-4070 Basel, SwitzerlandJürgen Wichmann, CNS Research, CNS Discovery, pRED, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, CH... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5618364 Tue, 17 Jan 2012 07:14:19 +0100 5618364 http://www.medworm.com/index.php?rid=5618365&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff25606668x2w5095%2F Conclusions  nAChRs are crucial for decision-making, during integration of emotional and motivational features, both mediated by different NT pathways in the PFC. We review the knowledge recently gained on cognitive functions in mice and our current understanding of PFC NT modulation. The combination of these data is expected to provide new hypotheses concerning the role of AChRs in cognitive processes. Content Type Journal ArticleCategory ReviewPages 1-18DOI 10.1007/s00213-011-2596-6Authors Renata dos Santos Coura, Centre de Neuroscience Paris Sud, Université Paris Sud XI, CNRS 8195, Orsay, FranceSylvie Granon, Centre de Neuroscience Paris Sud, Université Paris Sud XI, CNRS 8195, Orsay, France Journal PsychopharmacologyOnline ISSN 1432-2072Print ISSN 0033-... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5618365 Tue, 17 Jan 2012 07:14:17 +0100 5618365 http://www.medworm.com/index.php?rid=5618366&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx37261r158l57386%2F Conclusions  The results demonstrate that dysregulated and regulated intakes can be expressed within the same animal, indicating that escalation is context-dependent. Furthermore, escalated cocaine intake can be expressed under 1-h access conditions. Overall, these results suggest that escalated cocaine intake may be representative of discrimination-dependent regulated intake rather than addiction-like, compulsive intake. Content Type Journal ArticleCategory Original InvestigationPages 1-11DOI 10.1007/s00213-012-2641-0Authors Joshua S. Beckmann, Department of Psychology, University of Kentucky, 741 S. Limestone, 448C BBSRB, Lexington, KY 40536-0509, USACassandra D. Gipson, Department of Neurosciences, Medical University of South Carolina, Charleston, SC, USAJulie A.... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5618366 Tue, 17 Jan 2012 07:14:16 +0100 5618366 http://www.medworm.com/index.php?rid=5595207&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj245w430333t0205%2F Conclusions  The present data suggest that high anxiety predisposes rats to lose control over cocaine—but not heroin—intake. High anxiety may therefore be a vulnerability trait for the escalation of stimulant but not opiate self-administration. Content Type Journal ArticleCategory Original InvestigationPages 1-9DOI 10.1007/s00213-011-2626-4Authors Ruth Dilleen, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge, CB2 3EB UKYann Pelloux, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge, CB2 3EB UKAdam C. Mar, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge, CB2 3EB UKAnna Molander, CNS Pharmacology–Psychiatry, Neur... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5595207 Fri, 13 Jan 2012 16:48:47 +0100 5595207 http://www.medworm.com/index.php?rid=5595209&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg66x006q734r4516%2F Conclusions  In the present study, preferential extrastriatal dopamine D2 receptor occupancy by aripiprazole was not observed. Our data suggest partial agonism at dopamine D2 receptors is the most likely explanation for the minimal risk of extrapyramidal side effects in the treatment by aripiprazole. Content Type Journal ArticleCategory Original InvestigationPages 1-8DOI 10.1007/s00213-011-2633-5Authors Keisuke Takahata, Clinical Neuroimaging Team, Molecular Neuroimaging Program, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, JapanHiroshi Ito, Clinical Neuroimaging Team, Molecular Neuroimaging Program, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, JapanHarumasa Takano, Clinical Neuroimaging Team, Molecular ... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5595209 Wed, 11 Jan 2012 17:55:37 +0100 5595209 http://www.medworm.com/index.php?rid=5595208&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq7j026q116730878%2F Conclusions  Results generally supported the hypothesis that patients treated with risperidone perform more like those treated with typical antipsychotics than those treated with other atypical antipsychotics. Content Type Journal ArticleCategory Original InvestigationPages 1-11DOI 10.1007/s00213-011-2634-4Authors James I. Wasserman, Department of Psychology, Queen’s University, 62 Arch St., Kingston, ON K7L 3N6, CanadaRebecca J. Barry, Department of Psychology, Queen’s University, 62 Arch St., Kingston, ON K7L 3N6, CanadaLisa Bradford, Department of Psychology, Queen’s University, 62 Arch St., Kingston, ON K7L 3N6, CanadaNicholas J. Delva, Department of Psychiatry, Queen’s University, Kingston, ON, CanadaRichard J. Beninger, Department of Psychology, Queen’... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5595208 Wed, 11 Jan 2012 17:55:37 +0100 5595208 http://www.medworm.com/index.php?rid=5595213&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F887vxxh3p73638h3%2F Conclusions  Risperidone administered at low doses did not elicit clinically detectable EPS but had significant effects on balance control. A dose–response effect on impairment of balance was observed that followed the expected time course of the drug pharmacokinetics. These results are likely to apply to older or demented individuals who have pre-existing balance control deficit. Content Type Journal ArticleCategory Original InvestigationPages 1-11DOI 10.1007/s00213-011-2623-7Authors Philippe Corbeil, Groupe de recherche en analyse du mouvement et ergonomie, Faculté de médecine, kinésiologie Université Laval, 2300, rue de la Terrasse, Québec, QC G1V 0A6 CanadaJulien Rodrigue, Groupe de recherche en analyse du mouvement et ergonomie, Faculté de médecine, kin... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5595213 Tue, 10 Jan 2012 17:00:06 +0100 5595213 http://www.medworm.com/index.php?rid=5595212&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq734827653q61v57%2F Conclusion  The study shows differing activation towards smoking images following exercise compared to a control treatment and may point to a neuro-cognitive process following exercise that mediates effects on cigarette cravings. Content Type Journal ArticleCategory Original InvestigationPages 1-8DOI 10.1007/s00213-011-2610-zAuthors Kate Janse Van Rensburg, Tobacco Research and Intervention Program, Moffitt Cancer Center, 4115 E. Fowler Avenue, Tampa, FL 33617 USAAdrian Taylor, School of Sport and Health Sciences, University of Exeter, St Luke’s Campus, Exeter, EX1 2LU UKAbdelmalek Benattayallah, MR Research Center, University of Exeter, St. Luke’s Campus, Exeter, EX1 2LU UKTim Hodgson, School of Psychology, University of Lincoln, LN6 7TS Lincoln, UK Journa... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5595212 Tue, 10 Jan 2012 17:00:06 +0100 5595212 http://www.medworm.com/index.php?rid=5595211&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F15303gq127613537%2F Conclusions  The reduction of cocaine cue reactivity in the PBO group suggests that the study procedures were sufficient to produce extinction. Under these conditions, DCS did not facilitate extinction and may have enhanced craving. Further studies of glutamatergic agents and extinction in cocaine dependence should include consideration of procedural variables that could have a major impact on study outcomes. Content Type Journal ArticleCategory Original InvestigationPages 1-8DOI 10.1007/s00213-011-2592-xAuthors Kimber L. Price, Department of Psychiatry and Behavioral Sciences, Division of Clinical Neuroscience, Medical University of South Carolina, 67 President Street MSC 861, Charleston, SC 29425, USANathaniel L. Baker, Department of Medicine, Division of Biostati... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5595211 Tue, 10 Jan 2012 17:00:06 +0100 5595211 http://www.medworm.com/index.php?rid=5595210&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F93766812j517168q%2F Conclusions  This study furthers the theory that gender may impact on the nature of, and susceptibility to, certain side effects of antipsychotics. In addition, we demonstrate, what is to our knowledge the first time, an altered microbiota associated with chronic olanzapine treatment. Content Type Journal ArticleCategory Original InvestigationPages 1-15DOI 10.1007/s00213-011-2555-2Authors Kieran J. Davey, Alimentary Pharmabiotic Centre, Laboratory of Neurogastroenterology, University College Cork, Cork, IrelandSiobhain M. O’Mahony, Alimentary Pharmabiotic Centre, Laboratory of Neurogastroenterology, University College Cork, Cork, IrelandHarriet Schellekens, School of Pharmacy, University College Cork, Cork, IrelandOrla O’Sullivan, Alimentary Pharmabiotic Centre, ... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5595210 Tue, 10 Jan 2012 17:00:06 +0100 5595210 http://www.medworm.com/index.php?rid=5579268&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F83071xjm32981175%2F Content Type Journal ArticleCategory Letter to the EditorsPages 1-2DOI 10.1007/s00213-011-2614-8Authors Sarah Leibowitz, Behavioral Neurobiology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA Journal PsychopharmacologyOnline ISSN 1432-2072Print ISSN 0033-3158 (Source: Psychopharmacology) Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5579268 Fri, 06 Jan 2012 16:49:32 +0100 5579268 http://www.medworm.com/index.php?rid=5579269&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy5p426206j33v858%2F Conclusions  These results indicate that 5-HT1A agonism is adequate to ameliorate the PCP-induced impairment in NOR and suggest further study of utilizing the combination of a 5-HT1A agonist and an atypical APD to ameliorate some types of cognitive impairment in schizophrenia. Content Type Journal ArticleCategory Original InvestigationPages 1-11DOI 10.1007/s00213-011-2561-4Authors M. Horiguchi, Division of Psychopharmacology, Vanderbilt University Medical Center, Nashville, TN 37212, USAH. Y. Meltzer, Division of Psychopharmacology, Vanderbilt University Medical Center, Nashville, TN 37212, USA Journal PsychopharmacologyOnline ISSN 1432-2072Print ISSN 0033-3158 (Source: Psychopharmacology) Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5579269 Fri, 06 Jan 2012 16:49:30 +0100 5579269 http://www.medworm.com/index.php?rid=5579271&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F681187435n84u57l%2F Conclusion  These data suggest that the binding of [11C]yohimbine to α2 adrenoceptors may be displaceable by increases in synaptic concentrations of the endogenous ligand, NA, and possibly dopamine, suggesting the possibility that [11C]yohimbine may be used as a surrogate marker of NA release in vivo. Content Type Journal ArticleCategory Original InvestigationPages 1-9DOI 10.1007/s00213-011-2632-6Authors Anne M. Landau, Department of Nuclear Medicine and PET Center, Aarhus University Hospital, Norrebrogade 44, Building 10G, Aarhus C, 8000 DenmarkDoris J. Doudet, Department of Nuclear Medicine and PET Center, Aarhus University Hospital, Norrebrogade 44, Building 10G, Aarhus C, 8000 DenmarkSteen Jakobsen, Department of Nuclear Medicine and PET Center, Aarhus Universit... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5579271 Fri, 06 Jan 2012 16:49:27 +0100 5579271 http://www.medworm.com/index.php?rid=5579270&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn475p16qh3387273%2F Conclusions  Women may be more likely to choose to smoke after drinking moderate amounts of alcohol because of their expectations rather than the pharmacological effects of the alcohol. Content Type Journal ArticleCategory Original InvestigationPages 1-10DOI 10.1007/s00213-011-2624-6Authors Christopher W. Kahler, Center for Alcohol and Addiction Studies, Brown University, Box G-S121-5, Providence, RI 02912, USAJane Metrik, Center for Alcohol and Addiction Studies, Brown University, Box G-S121-5, Providence, RI 02912, USANichea S. Spillane, Center for Alcohol and Addiction Studies, Brown University, Box G-S121-5, Providence, RI 02912, USAAdam M. Leventhal, Departments of Preventive Medicine and Psychology, University of Southern California Keck School of Medicine, Los ... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5579270 Fri, 06 Jan 2012 16:49:27 +0100 5579270 http://www.medworm.com/index.php?rid=5579272&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fmu44112wtt67n804%2F Conclusions  These findings highlight the importance of the serotonergic system in the modulation of aggression and suggest that the behaviorally specific effects of 5-HT1B receptor agonists are regionally selective. 5-HT1B receptors in a medial subregion of the prefrontal cortex, the ILC, appear to be critically involved in the attenuation of species-typical levels of aggression. Content Type Journal ArticleCategory Original InvestigationPages 1-12DOI 10.1007/s00213-011-2629-1Authors S. Faccidomo, Department of Psychology, Tufts University, Medford, MA 02155, USAI. M. H. Quadros, Department of Psychology, Tufts University, Medford, MA 02155, USAA. Takahashi, Department of Psychology, Tufts University, Medford, MA 02155, USAE. W. Fish, Department of Psychology, Tufts... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5579272 Fri, 06 Jan 2012 06:43:34 +0100 5579272 http://www.medworm.com/index.php?rid=5579273&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa78864lx44430382%2F Conclusions  We conclude that decreased D1R expression into the NAc led to reduced ethanol rewarding properties, thereby leading to lower voluntary ethanol consumption. Together, these findings demonstrate that the D1 receptor pathway within the NAc controls ethanol reward and intake. Content Type Journal ArticleCategory Original InvestigationPages 1-13DOI 10.1007/s00213-011-2630-8Authors Amine Bahi, Department of Anatomy, Faculty of Medicine & Health Sciences, United Arab Emirates University, Tawam Medical Campus, PO Box 17666, Al Ain, United Arab EmiratesJean-Luc Dreyer, Division of Biochemistry, Department of Medicine, University of Fribourg, Fribourg, Switzerland Journal PsychopharmacologyOnline ISSN 1432-2072Print ISSN 0033-3158 (Source: Psychopharmacolog... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5579273 Thu, 05 Jan 2012 17:01:03 +0100 5579273 http://www.medworm.com/index.php?rid=5579275&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg846711607584741%2F Conclusion  These results demonstrate that although DHX and DOX have similar activity after intraperitoneal administration, DOX demonstrated greater activity after oral administration compared to DHX. Despite its catechol functionality, DOX may possess sufficient oral availability for development as a human therapeutic agent. Content Type Journal ArticleCategory Original InvestigationPages 1-7DOI 10.1007/s00213-011-2625-5Authors John D. McCorvy, Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy and Integrative Neuroscience Program, Purdue University, West Lafayette, IN 47907, USAVal J. Watts, Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy and Integrative Neuroscience Program, Purdue University, West L... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5579275 Thu, 05 Jan 2012 17:01:01 +0100 5579275 http://www.medworm.com/index.php?rid=5579274&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9302188085w27017%2F Conclusions  The finding with α,α,β,β-tetradeutero-5-MeO-DMT indicates that the hyperactivity induced by 5-MeO-DMT after MAO inhibition is a consequence of reduced metabolism of 5-MeO-DMT, leading to prolonged occupation of central serotonin receptors. These results demonstrate that deuterated tryptamines may be useful in behavioral and pharmacological studies to mimic the effects of tryptamine/MAOI combinations. Content Type Journal ArticleCategory Original InvestigationPages 1-10DOI 10.1007/s00213-011-2616-6Authors Adam L. Halberstadt, Department of Psychiatry, University of California San Diego, La Jolla, CA, USADavid E. Nichols, Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy—RHPH, Purdue University, West Lafayette, IN, US... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5579274 Thu, 05 Jan 2012 17:01:01 +0100 5579274 http://www.medworm.com/index.php?rid=5570624&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj22500urm685l413%2F Conclusion  The results indicate that chemical analogs of nicotine can play a role in nicotine self-administration harm reduction but a non-nAChR and a non-hDAT mechanism are likely involved. Content Type Journal ArticleCategory Original InvestigationPages 1-12DOI 10.1007/s00213-011-2608-6Authors John R. Cashman, Human BioMolecular Research Institute, 5310 Eastgate Mall, San Diego, CA 92121, USAKarl Okolotowicz, Human BioMolecular Research Institute, 5310 Eastgate Mall, San Diego, CA 92121, USAMatt Cerny, Human BioMolecular Research Institute, 5310 Eastgate Mall, San Diego, CA 92121, USARobert Johnson, Veterans Administrative Hospital, Portland, OR 97201, USAAaron Janowsky, Veterans Administrative Hospital, Portland, OR 97201, USAMarc R. Azar, Behavioral Pharma Inc., ... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5570624 Wed, 04 Jan 2012 16:51:37 +0100 5570624 http://www.medworm.com/index.php?rid=5570625&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F4561v21177542h46%2F Conclusions  Combined with earlier findings, these results suggest a model of changing trajectories whereby FA is higher with tobacco exposure during adolescence and declines with continued smoking in adulthood. This notion is supported by the observation that, at multiple sampling sites, participants who had started smoking earlier in life had higher FA than those who had started later. Content Type Journal ArticleCategory Original InvestigationPages 1-11DOI 10.1007/s00213-011-2621-9Authors Matthew Hudkins, Division of Child and Adolescent Psychiatry, UCLA Semel Institute for Neurosciences and Biobehavioral Studies, 760 Westwood Plaza #58-227A, Los Angeles, CA 90024-1759, USAJoseph O’Neill, Division of Child and Adolescent Psychiatry, UCLA Semel Institute for Neur... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5570625 Wed, 04 Jan 2012 06:58:17 +0100 5570625 http://www.medworm.com/index.php?rid=5557500&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw8lt274048230n58%2F Conclusions  Eating high-fat chow or restricting access to food alters sensitivity to direct-acting dopamine receptor agonists (apomorphine, quinpirole), although the relative contribution of drug history and dietary conditions to sensitivity changes appears to vary among agonists. Content Type Journal ArticleCategory Original InvestigationPages 1-10DOI 10.1007/s00213-011-2620-xAuthors Michelle G. Baladi, Department of Pharmacology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USAYvonne M. Thomas, Department of Pharmacology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USACharles P. France, Department of Pharmacology, University of Texas Hea... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5557500 Fri, 30 Dec 2011 06:50:26 +0100 5557500 http://www.medworm.com/index.php?rid=5557502&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F5un200856977p613%2F Conclusions  Drug-related cues aggravated decision making and increased craving in former heroin addicts who had been drug-free for 1–24 months, which might have significant clinical implications for the prevention of relapse. Content Type Journal ArticleCategory Original InvestigationPages 1-8DOI 10.1007/s00213-011-2617-5Authors Gui-Bin Wang, National Institute on Drug Dependence, Peking University, Beijing, 100191 ChinaXiao-Li Zhang, National Institute on Drug Dependence, Peking University, Beijing, 100191 ChinaLi-Yan Zhao, National Institute on Drug Dependence, Peking University, Beijing, 100191 ChinaLi-Li Sun, National Institute on Drug Dependence, Peking University, Beijing, 100191 ChinaPing Wu, National Institute on Drug Dependence, Peking University, Bei... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5557502 Fri, 30 Dec 2011 06:50:25 +0100 5557502 http://www.medworm.com/index.php?rid=5557501&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm4378q528525774t%2F Conclusions  These results clearly demonstrate that excessive opiate intake and withdrawal produces dramatic and long-lasting motivational disorders relevant to drug dependence. Content Type Journal ArticleCategory Original InvestigationPages 1-10DOI 10.1007/s00213-011-2612-xAuthors Khalil Rouibi, Addicteam, Université de Bordeaux, CNRS UMR 5287, 146 rue Léo Saignat, 33076 Bordeaux, FranceAngelo Contarino, Addicteam, Université de Bordeaux, CNRS UMR 5287, 146 rue Léo Saignat, 33076 Bordeaux, France Journal PsychopharmacologyOnline ISSN 1432-2072Print ISSN 0033-3158 (Source: Psychopharmacology) Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5557501 Fri, 30 Dec 2011 06:50:25 +0100 5557501 http://www.medworm.com/index.php?rid=5557503&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F557u041m4103628n%2F Conclusion  Collectively, our data indicate that the short-term effects of fluoxetine on the 5-HT system may be age-dependent. These findings could reflect structural and functional rearrangements in the developing brain that do not occur in the matured rat brain. phMRI possibly will be well suited to study this important issue in the pediatric population. Content Type Journal ArticleCategory Original InvestigationPages 1-11DOI 10.1007/s00213-011-2580-1Authors Valentine Bouet, Groupe Mémoire et Plasticité comportementale (GMPc), Université de Caen Basse-Normandie, EA 4259, Caen, 14032 FranceAnne Klomp, Radiology Department, Academic Medical Center, Brain Imaging Center, Amsterdam, The NetherlandsThomas Freret, Groupe Mémoire et Plasticité comportementale (GMPc),... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5557503 Wed, 28 Dec 2011 16:45:31 +0100 5557503 http://www.medworm.com/index.php?rid=5557504&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F2128q67747g421kn%2F Conclusions  Cue-elicited HFHRV and alcohol AB can presage relapse and may therefore hold promise as prognostic indicators in clinical settings. Content Type Journal ArticleCategory Original InvestigationPages 1-10DOI 10.1007/s00213-011-2618-4Authors Eric L. Garland, College of Social Work, Trinity Institute for the Addictions, Florida State University, University Center, Building C, Tallahassee, FL 32306-2570, USAIngmar H. A. Franken, Erasmus University Rotterdam, 3000 DR, Rotterdam, The NetherlandsMatthew O. Howard, University of North Carolina, Chapel Hill, NC 27599-3550, USA Journal PsychopharmacologyOnline ISSN 1432-2072Print ISSN 0033-3158 (Source: Psychopharmacology) Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5557504 Wed, 28 Dec 2011 06:53:42 +0100 5557504 http://www.medworm.com/index.php?rid=5557505&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F904px64322507q58%2F Conclusion  Suppression of activity in this area during task performance may reflect a compensatory mechanism by which MPH ameliorates attention impairments in TBI. Content Type Journal ArticleCategory Original InvestigationPages 1-11DOI 10.1007/s00213-011-2622-8Authors Junghoon Kim, Moss Rehabilitation Research Institute, Albert Einstein Healthcare Network, 50 Township Line Rd., Elkins Park, PA 19027, USAJohn Whyte, Moss Rehabilitation Research Institute, Albert Einstein Healthcare Network, 50 Township Line Rd., Elkins Park, PA 19027, USASunil Patel, Moss Rehabilitation Research Institute, Albert Einstein Healthcare Network, 50 Township Line Rd., Elkins Park, PA 19027, USAEduardo Europa, Moss Rehabilitation Research Institute, Albert Einstein Healthcare Network, 50 T... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5557505 Wed, 28 Dec 2011 06:53:41 +0100 5557505 http://www.medworm.com/index.php?rid=5557506&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fqn81615l061031hk%2F Conclusion  In this proof-of-concept study, RX-10100 treatment (5 mg twice daily) improved MADRS scores in subjects with severe depression. RX-10100 does not appear to have many of the typical side effects of other antidepressants. These results indicate a need for larger studies further evaluating RX-10100 at 5 mg and lower doses. Content Type Journal ArticleCategory Original InvestigationPages 1-10DOI 10.1007/s00213-011-2604-xAuthors Robert Riesenberg, Atlanta Center for Medical Research, Atlanta, GA, USAJoshua Rosenthal, Capital Clinical Research Associates, Rockville, MD, USALeslie Moldauer, Segal Institute for Clinical Research, Miami, FL, USAChristine Peterson, Rexahn Pharmaceuticals, Inc., Rockville, MD, USA Journal PsychopharmacologyOnline IS... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5557506 Wed, 28 Dec 2011 06:53:40 +0100 5557506 http://www.medworm.com/index.php?rid=5557507&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb75820645r728071%2F Conclusion  It is therefore likely that SFN can be a useful drug for the treatment of signs associated with METH abuse in humans. Content Type Journal ArticleCategory Original InvestigationPages 1-9DOI 10.1007/s00213-011-2619-3Authors Hongxian Chen, Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1-8-1 Inohana, Chiba, 260-8670 JapanJin Wu, Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1-8-1 Inohana, Chiba, 260-8670 JapanJichun Zhang, Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1-8-1 Inohana, Chiba, 260-8670 JapanYuko Fujita, Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1-8-1 Inohana, Chiba, 260-8670 JapanTama... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5557507 Tue, 27 Dec 2011 06:34:09 +0100 5557507 http://www.medworm.com/index.php?rid=5542935&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh387q323p2113461%2F Conclusions  Our results demonstrate a modulatory influence of sibutramine on amygdala activity in obese women which may underlie the appetite suppressant effects of the drug. Content Type Journal ArticleCategory Original InvestigationPages 1-8DOI 10.1007/s00213-011-2615-7Authors Kerstin M. Oltmanns, Department of Psychiatry and Psychotherapy, University of Luebeck, Ratzeburger Allee 160, 23538 Luebeck, GermanyMarcus Heldmann, Department of Neurology, University of Luebeck, Ratzeburger Allee 160, 23538 Luebeck, GermanySusanne Daul, Division of Endocrinology and Metabolism, Magdeburg University Medical School, Otto von Guericke University Magdeburg, Magdeburg, GermanySilke Klose, Division of Endocrinology and Metabolism, Magdeburg University Medical School, Otto von Gu... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5542935 Fri, 23 Dec 2011 06:49:12 +0100 5542935 http://www.medworm.com/index.php?rid=5542937&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg36515772655x202%2F Conclusions  The present data demonstrate that RGS4 in the dSTR attenuates amphetamine-induced ERK signaling and decreases the behavioral efficacy of acute amphetamine likely by limiting mGluR5 function. Content Type Journal ArticleCategory Original InvestigationPages 1-15DOI 10.1007/s00213-011-2606-8Authors Marek Schwendt, Department of Neurosciences, Medical University of South Carolina, 173 Ashley Avenue, BSB 403, MSC 510, Charleston, SC 29425-5100, USAStacey A. Sigmon, Department of Neurosciences, Medical University of South Carolina, 173 Ashley Avenue, BSB 403, MSC 510, Charleston, SC 29425-5100, USAJacqueline F. McGinty, Department of Neurosciences, Medical University of South Carolina, 173 Ashley Avenue, BSB 403, MSC 510, Charleston, SC 29425-5100, USA J... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5542937 Fri, 23 Dec 2011 06:49:10 +0100 5542937 http://www.medworm.com/index.php?rid=5542936&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fqwg36863892368k6%2F Conclusion  Isotretinoin does not reduce learning and memory and our study suggests that it may instead lead to a dose-related improvement in specific aspects of hippocampal learning and memory. Retinoic acid functions in the hippocampus as the active metabolite of vitamin A, suggesting that this may be a limiting factor in the human hippocampus and addition of exogenous retinoic acid brings levels closer to an optimal state. Content Type Journal ArticleCategory Original InvestigationPages 1-8DOI 10.1007/s00213-011-2611-yAuthors Anthony D. Ormerod, Division of Applied Medicine, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen, AB25 2ZN UKChamandeep K. Thind, Department of Dermatology, Aberdeen Royal Infirmary, Aberdeen, UKShantini A. Rice, Departmen... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5542936 Fri, 23 Dec 2011 06:49:10 +0100 5542936 http://www.medworm.com/index.php?rid=5542938&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx566658443317770%2F Conclusions  Two-point tracking is effective for studying vigilant scanning in mice. Using this approach, we show that scanning is a key risk assessment activity in both unconditioned and conditioned mice; scanning is resistant to threat-induced behavioral inhibition and is highly sensitive to anxiolytic treatment. Content Type Journal ArticleCategory Original InvestigationPages 1-9DOI 10.1007/s00213-011-2609-5Authors Kwok Ho C. Choy, Department of Pharmacology, University of Melbourne, Melbourne, Victoria 3010, AustraliaJing Yu, Department of Pharmacology, University of Melbourne, Melbourne, Victoria 3010, AustraliaDavid Hawkes, Department of Pharmacology, University of Melbourne, Melbourne, Victoria 3010, AustraliaDmitry N. Mayorov, Department of Pharmacology, Univ... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5542938 Fri, 23 Dec 2011 06:49:08 +0100 5542938 http://www.medworm.com/index.php?rid=5522072&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu58044025m738618%2F Conclusions  Caffeine appears to have mixed effects on alcohol intoxication that are task-dependent. We found increased stimulation in the alcohol/caffeine condition, supporting the contention that caffeinated alcoholic beverages enable an individual to drink for longer. Future research should model real world drinking behaviour by examining how these effects change across multiple drink administrations. Content Type Journal ArticleCategory Original InvestigationPages 1-10DOI 10.1007/s00213-011-2601-0Authors Angela S. Attwood, School of Experimental Psychology, University of Bristol, 12a Priory Road, Bristol, BS8 1TU UKPeter J. Rogers, School of Experimental Psychology, University of Bristol, 12a Priory Road, Bristol, BS8 1TU UKAlia F. Ataya, School of Experimental ... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5522072 Fri, 16 Dec 2011 06:53:07 +0100 5522072 http://www.medworm.com/index.php?rid=5522073&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F95288130t5146h62%2F Content Type Journal ArticleCategory Letter to the EditorsPages 1-3DOI 10.1007/s00213-011-2607-7Authors Josip Podobnik, Department of Psychiatry, Psychiatric Hospital for Children and Youth Zagreb, Kukuljeviceva 11, 10000 Zagreb, CroatiaIris Foller Podobnik, Department of Psychiatry, Psychiatric Hospital for Children and Youth Zagreb, Kukuljeviceva 11, 10000 Zagreb, CroatiaNeda Grgic, Department of Psychiatry, Psychiatric Hospital for Children and Youth Zagreb, Kukuljeviceva 11, 10000 Zagreb, CroatiaDarko Marcinko, Department of Psychiatry, University Hospital Centre Zagreb, School of Medicine, University of Zagreb, Kispaticeva 12, 10000 Zagreb, CroatiaNela Pivac, Division of Molecular Medicine, Rudjer Boskovic Institute, Bijenicka 54, 10000 Zagreb, Croatia Journal Psychopharmac... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5522073 Thu, 15 Dec 2011 16:50:03 +0100 5522073 http://www.medworm.com/index.php?rid=5522074&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp2656l6076815068%2F Conclusions  There was considerable overlap between some elements of impulsivity and mindfulness while the overlap was negligible for other facets. The associations between mindfulness and alcohol misuse were entirely a function of impulsivity. In particular, acting on impulses while experiencing a negative affect was significantly associated with level of alcohol consumption and level of alcohol-related risk. Steep discounting of future rewards was associated with alcohol consumption while poor premeditation was associated with adverse drinking consequences. These findings illustrate the importance of jointly studying impulsivity when examining mindfulness traits. Content Type Journal ArticleCategory Original InvestigationPages 1-10DOI 10.1007/s00213-011-2573-0Auth... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5522074 Thu, 15 Dec 2011 06:44:38 +0100 5522074 http://www.medworm.com/index.php?rid=5513726&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa923871k5t310203%2F Conclusions  To the best of our knowledge, this is the first study reporting enhanced declarative memory consolidation after methylphenidate in a dose-related fashion over a dose range that is presumed to reflect a wide range of dopamine reuptake inhibition. Content Type Journal ArticleCategory Original InvestigationPages 1-9DOI 10.1007/s00213-011-2605-9Authors A. M. W. Linssen, Department of Neuropsychology & Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, PO Box 616, 6200 MD, Maastricht, The NetherlandsE. F. P. M. Vuurman, Department of Neuropsychology & Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, PO Box 616, 6200 MD, Maastricht, The NetherlandsA. Sambeth, Department of Neuropsychology & Psych... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5513726 Wed, 14 Dec 2011 16:40:26 +0100 5513726 http://www.medworm.com/index.php?rid=5513727&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F763651v38k0h6275%2F Conclusions  CeA μ-opioid stimulation specifically enhances incentive salience, which is dynamically guided to food or sex by available cues. Content Type Journal ArticleCategory Original InvestigationPages 1-20DOI 10.1007/s00213-011-2588-6Authors Stephen V. Mahler, Department of Psychology, University of Michigan, Ann Arbor, MI, USAKent C. Berridge, Department of Psychology, University of Michigan, Ann Arbor, MI, USA Journal PsychopharmacologyOnline ISSN 1432-2072Print ISSN 0033-3158 (Source: Psychopharmacology) Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5513727 Tue, 13 Dec 2011 17:04:38 +0100 5513727 http://www.medworm.com/index.php?rid=5513728&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb6x3w960l295g0w5%2F Conclusion  TNF-α affects METH self-administration and motivation to self-administer METH but contributes to neither METH-associated cue-induced relapsing behavior nor food reward and food-seeking behavior. TNF-α may be explored for use as a diagnostic biomarker for the early stage of drug addiction. Content Type Journal ArticleCategory Original InvestigationPages 1-10DOI 10.1007/s00213-011-2589-5Authors Yijin Yan, Department of Neuropsychopharmacology and Hospital Pharmacy, Graduate School of Medicine, Nagoya University, Nagoya, 466-8560 JapanAtsumi Nitta, Department of Neuropsychopharmacology and Hospital Pharmacy, Graduate School of Medicine, Nagoya University, Nagoya, 466-8560 JapanTakenao Koseki, Department of Chemical Pharmacology, Graduate School of Pharmace... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5513728 Tue, 13 Dec 2011 06:58:04 +0100 5513728 http://www.medworm.com/index.php?rid=5502721&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft001557034182482%2F Conclusion  The synergistic blocking effects of I Na and I Na(NI) contributes to the main mechanism through which EUG affects the firing of neuronal APs and modulate neuronal hyperexcitability such as pilocarpine-induced temporal lobe seizures. Content Type Journal ArticleCategory Original InvestigationPages 1-13DOI 10.1007/s00213-011-2603-yAuthors Chin-Wei Huang, Department of Neurology, National Cheng Kung University Hospital, Tainan, TaiwanJulie Chi Chow, Department of Pediatric Neurology, Chi-Mei Foundation Medical Center, Tainan, TaiwanJing-Jane Tsai, Department of Neurology, National Cheng Kung University Hospital, Tainan, TaiwanSheng-Nan Wu, Department of Physiology, National Cheng Kung University Medical College, 1 University Road, Tainan, 70101 Taiwan ... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5502721 Mon, 12 Dec 2011 17:12:05 +0100 5502721 http://www.medworm.com/index.php?rid=5502722&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr61l3471t622126t%2F Conclusion  A deficiency in PPARγ increases vulnerability to high doses of methamphetamine. Endogenous PPARγ may play an important role in reducing methamphetamine toxicity in vivo. Content Type Journal ArticleCategory Original InvestigationPages 1-14DOI 10.1007/s00213-011-2595-7Authors Seong-Jin Yu, National Institute on Drug Abuse, IRP, Neural Protection and Regeneration Section, 251 Bayview Boulevard, 06-721A, Baltimore, MD 21224, USAMikko Airavaara, National Institute on Drug Abuse, IRP, Neural Protection and Regeneration Section, 251 Bayview Boulevard, 06-721A, Baltimore, MD 21224, USAHui Shen, National Institute on Drug Abuse, IRP, Neural Protection and Regeneration Section, 251 Bayview Boulevard, 06-721A, Baltimore, MD 21224, USAJenny Chou, National Institute... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5502722 Mon, 12 Dec 2011 17:12:04 +0100 5502722 http://www.medworm.com/index.php?rid=5493305&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu3l6247143511643%2F Conclusions  Agomelatine modulates cytoskeletal microtubule dynamics and synaptic markers. This may play a role in its pharmacological behavioural effects and may result from the melatonergic agonist and 5-HT2C antagonist properties of the compound. Content Type Journal ArticleCategory Original InvestigationPages 1-17DOI 10.1007/s00213-011-2597-5Authors Nataly Ladurelle, Institut National de la Santé et de la Recherche Médicale-UMR788, Le Kremlin-Bicêtre, FranceCecilia Gabriel, Institut de Recherches International Servier, Courbevoie, FranceAdela Viggiano, Psychopharmacology Team, MAPREG, Bldg. Gregory PINCUS 80, rue du General Leclerc, 94276 Le Kremlin-Bicetre Cedex, FranceElisabeth Mocaër, Institut de Recherches International Servier, Courbevoie, FranceEtienne E... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5493305 Wed, 07 Dec 2011 10:47:50 +0100 5493305 http://www.medworm.com/index.php?rid=5493306&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F35q1531g077r5m73%2F Content Type Journal ArticleCategory ErratumPages 1-1DOI 10.1007/s00213-011-2591-yAuthors Serge H. Ahmed, Université de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, CNRS, Institut des Maladies Neurodégénératives, UMR 5293, 33000 Bordeaux, FranceGeorge F. Koob, Committee on the Neurobiology of Addictive Disorder, The Scripps Research Institute, La Jolla, CA 92103, USA Journal PsychopharmacologyOnline ISSN 1432-2072Print ISSN 0033-3158 (Source: Psychopharmacology) Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5493306 Wed, 07 Dec 2011 10:47:47 +0100 5493306 http://www.medworm.com/index.php?rid=5493307&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft4428574n7m40n47%2F Conclusions  Our results provide in vivo evidence for agonist-induced D2R trafficking that is inversely related to CB1R distribution in postsynaptic neurons of Acb shell and in presynaptic axons in this region and in the CPu. Content Type Journal ArticleCategory Original InvestigationPages 1-13DOI 10.1007/s00213-011-2553-4Authors Diane A. Lane, Department of Neurology and Neuroscience, Weill-Cornell Medical College, New York, NY 10065, USAJune Chan, Department of Neurology and Neuroscience, Weill-Cornell Medical College, New York, NY 10065, USAMegan L. Fitzgerald, Department of Neurology and Neuroscience, Weill-Cornell Medical College, New York, NY 10065, USAChris S. Kearn, Department of Anesthesiology, University of Washington, Seattle, WA 98195, USAKen Mackie, Depart... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5493307 Wed, 07 Dec 2011 10:47:46 +0100 5493307 http://www.medworm.com/index.php?rid=5493308&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa232mw65460543m5%2F Conclusion  Our results point to a lateralized modulatory effect of VIP injected in the hippocampal CA1 area on the avoidance deficits in OBX rats. The right CA1 area was predominantly involved in the positive effect of VIP on learning and memory. A possible role of the PAC1 receptors is suggested. Content Type Journal ArticleCategory Original InvestigationPages 1-14DOI 10.1007/s00213-011-2600-1Authors Margarita Ivanova, Department of Physiology and Pathophysiology, Medical University Varna, 55 Marin Drinov St., 9000 Varna, BulgariaStiliana Belcheva, Department of Behavioral Neurobiology, Institute of Neurobiology, Bulgarian Academy of Sciences, Acad. G. Bonchev St., bl. 23, 1113 Sofia, BulgariaIren Belcheva, Department of Behavioral Neurobiology, Institute of Neurob... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5493308 Wed, 07 Dec 2011 10:47:44 +0100 5493308 http://www.medworm.com/index.php?rid=5493310&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl0h4v64h2738n854%2F Conclusions  These results indicate that, upon systemic administration, F13640 activates both 5-HT1A autoreceptors and postsynaptic 5-HT1A receptors in prefrontal cortex with a similar potency. Both activities are likely involved in the analgesic properties of the compound. Content Type Journal ArticleCategory Original InvestigationPages 1-12DOI 10.1007/s00213-011-2569-9Authors Laia Lladó-Pelfort, Department of Neurochemistry and Neuropharmacology, Institut d’Investigacions Biomèdiques de Barcelona, CSIC-IDIBAPS, Rosselló 161, 6th floor, 08036 Barcelona, SpainMarie-Bernadette Assié, Neurobiology Division 2, Centre de Recherches Pierre Fabre, Castres, FranceAdrian Newman-Tancredi, Neurobiology Division 2, Centre de Recherches Pierre Fabre, Castres, FranceFrancesc... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5493310 Tue, 06 Dec 2011 17:03:17 +0100 5493310 http://www.medworm.com/index.php?rid=5493309&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F535g422161u4v844%2F Conclusions  mGlu5 receptor null mutation attenuates the anhedonic and somatic effects of psychostimulant withdrawal. This attenuated withdrawal in mGluR5−/− mice may result from the lack of drug-induced adaptations in mGlu5 receptor function that may occur in mGluR5+/+ mice with chronic drug administration. Thus, these results suggest the involvement of mGlu5 receptors in psychostimulant dependence and the mediation of the anhedonic and somatic signs of psychostimulant withdrawal. Content Type Journal ArticleCategory Original InvestigationPages 1-11DOI 10.1007/s00213-011-2578-8Authors Astrid K. Stoker, Department of Psychiatry, M/C 0603, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0603, USABerend Olivier, Divisio... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5493309 Tue, 06 Dec 2011 17:03:17 +0100 5493309 http://www.medworm.com/index.php?rid=5493311&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc4522644xj0l8pu1%2F Conclusions  These data suggest that stimulation of mGluR5s in the mPFC is sufficient to induce cocaine sensitization and is necessary for the expression of this sensitized response. Content Type Journal ArticleCategory Original InvestigationPages 1-10DOI 10.1007/s00213-011-2548-1Authors Kristin M. Timmer, Department of Pharmacology, University of Tennessee Health Science Center, 874 Union Ave., Rm. 115 Crowe, Memphis, TN 38163, USAJeffery D. Steketee, Department of Pharmacology, University of Tennessee Health Science Center, 874 Union Ave., Rm. 115 Crowe, Memphis, TN 38163, USA Journal PsychopharmacologyOnline ISSN 1432-2072Print ISSN 0033-3158 (Source: Psychopharmacology) Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5493311 Tue, 06 Dec 2011 17:03:16 +0100 5493311 http://www.medworm.com/index.php?rid=5493312&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fknu8h608n331041w%2F Conclusion  The possibility to substitute PCP by MK-801 in this model indicates that the effect is mediated by their common mechanism of NMDA antagonism. PDE10A inhibitors similar to clozapine significantly antagonize the increase of immobility, suggesting a therapeutic potential for the treatment of negative symptoms. However, further validation of the model is necessary. Content Type Journal ArticleCategory Original InvestigationPages 1-11DOI 10.1007/s00213-011-2567-yAuthors Barbara Langen, biocrea GmbH, Radebeul, GermanyRita Dost, biocrea GmbH, Radebeul, GermanyUte Egerland, biocrea GmbH, Radebeul, GermanyHans Stange, biocrea GmbH, Radebeul, GermanyNorbert Hoefgen, biocrea GmbH, Radebeul, Germany Journal PsychopharmacologyOnline ISSN 1432-2072Print ISSN 003... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5493312 Tue, 06 Dec 2011 17:03:15 +0100 5493312 http://www.medworm.com/index.php?rid=5493313&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F012427020q733420%2F Conclusions  Results indicate that inhibition of PKA enhances the unconditioned rewarding effect of D-1 receptor stimulation and that decreased PKA may be involved in the effect of FR on drug reward. Evidence for involvement of D-2 receptor-expressing neurons in the enhancing effect of PKA inhibition is discussed. Content Type Journal ArticleCategory Original InvestigationPages 1-11DOI 10.1007/s00213-011-2602-zAuthors Soledad Cabeza de Vaca, Department of Psychiatry, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USAXing-Xiang Peng, Department of Psychiatry, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USASeth Concors, Department of Psychiatry, New York University School of Medicine, 550 First Avenue, Ne... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5493313 Tue, 06 Dec 2011 06:59:28 +0100 5493313 http://www.medworm.com/index.php?rid=5493314&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx7646t2250518583%2F Conclusions  Our data suggest that GPR30 induces acute anxiogenic effects of oestrogen in rodents. It is tempting to speculate that a potential imbalance in the expression of the anxiolytic beta oestrogen receptor and the anxiogenic GPR30 may also be involved in the negative symptoms of oestrogen replacement therapy in humans. Content Type Journal ArticleCategory Original InvestigationPages 1-9DOI 10.1007/s00213-011-2599-3Authors Iris Kastenberger, Department of Pharmacology, Innsbruck Medical University, Peter-Mayr-Str. 1a, 6020 Innsbruck, AustriaChristian Lutsch, Department of Pharmacology, Innsbruck Medical University, Peter-Mayr-Str. 1a, 6020 Innsbruck, AustriaChristoph Schwarzer, Department of Pharmacology, Innsbruck Medical University, Peter-Mayr-Str. 1a, 6020 ... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5493314 Tue, 06 Dec 2011 06:59:24 +0100 5493314 http://www.medworm.com/index.php?rid=5484890&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp6516h1881672v31%2F Conclusions  Ethanol and MDMA co-administration increases the neurobehavioural changes induced by the consumption of each one of these drugs. However, as ethanol consumption did not increase neuroinflammatory responses induced by MDMA, other mechanisms, mediated by ethanol, are likely to account for this effect and need to be evaluated. Content Type Journal ArticleCategory Original InvestigationPages 1-15DOI 10.1007/s00213-011-2598-4Authors Clara Ros-Simó, Grup de Recerca en Neurobiologia del Comportament (GRNC). Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Parc de Recerca Biomèdica de Barcelona, Dr Aiguader 88, 08003 Barcelona, SpainJessica Ruiz-Medina, Grup de Recerca en Neurobiologia del Comportament (GRNC). Departament de Ciè... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5484890 Mon, 05 Dec 2011 06:33:14 +0100 5484890 http://www.medworm.com/index.php?rid=5484891&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx384528148410p77%2F Conclusions  Glutamatergic pathways are altered during differential rearing, which differentially alters the role of mGluR5 in EC, IC, and SC rats when administered psychostimulant acutely versus repeatedly. These findings suggest that differential rearing alters glutamatergic function, which reduces sensitivity to psychostimulants. Content Type Journal ArticleCategory Original InvestigationPages 1-11DOI 10.1007/s00213-011-2565-0Authors Margaret J. Gill, Department of Psychology, Kansas State University, 492 Bluemont Hall, Manhattan, KS 66506, USAJennifer C. Arnold, Department of Psychology, Kansas State University, 492 Bluemont Hall, Manhattan, KS 66506, USAMary E. Cain, Department of Psychology, Kansas State University, 492 Bluemont Hall, Manhattan, KS 66506, USA ... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5484891 Mon, 05 Dec 2011 06:33:13 +0100 5484891 http://www.medworm.com/index.php?rid=5474619&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj1458484647k258v%2F Conclusions  The present data support the predictive validity of the food reinstatement model and suggest that this model could be used to identify medications for prevention of relapse induced by stress or acute exposure to palatable food during dietary treatments. Content Type Journal ArticleCategory Original InvestigationPages 1-13DOI 10.1007/s00213-011-2585-9Authors Charles L. Pickens, Intramural Research Program, NIDA/NIH, Baltimore, MD, USACarlo Cifani, Intramural Research Program, NIDA/NIH, Baltimore, MD, USABrittany M. Navarre, Intramural Research Program, NIDA/NIH, Baltimore, MD, USAHila Eichenbaum, Intramural Research Program, NIDA/NIH, Baltimore, MD, USAFlorence R. Theberge, Intramural Research Program, NIDA/NIH, Baltimore, MD, USAMichael H. Baumann, Intram... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5474619 Fri, 02 Dec 2011 06:45:36 +0100 5474619 http://www.medworm.com/index.php?rid=5474621&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh324206127913266%2F Conclusions  Elevation of DA neurotransmission increases impulsive action and reduces impulsive choice. Increasing NA or 5-HT neurotransmission reduces impulsive action. Content Type Journal ArticleCategory Original InvestigationPages 1-14DOI 10.1007/s00213-011-2576-xAuthors Petra J. J. Baarendse, Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, UMC Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The NetherlandsLouk J. M. J. Vanderschuren, Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, UMC Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands Journal PsychopharmacologyOnline ISSN 1432-2072Print ISSN 0033-3158 (Source: Psychopharmacology) Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5474621 Fri, 02 Dec 2011 06:45:35 +0100 5474621 http://www.medworm.com/index.php?rid=5474620&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr1301745618067n1%2F Conclusions  We provide direct evidence that the balance between goal-directed and habitual control in humans is dopamine dependent. The results are discussed in light of gender differences in dopamine function and psychopathologies. Content Type Journal ArticleCategory Original InvestigationPages 1-11DOI 10.1007/s00213-011-2563-2Authors Sanne de Wit, Behavioral and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UKHolly R. Standing, Behavioral and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UKElise E. DeVito, Behavioral and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UKOliver J. Robinson, Behavioral and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UKK. Richard Ridderinkhof,... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5474620 Fri, 02 Dec 2011 06:45:35 +0100 5474620 http://www.medworm.com/index.php?rid=5474622&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy634756322651780%2F Conclusions  These data suggest that a recovery of function has occurred for the learning of the CS–US association, while the accurate timing of the CR shows lasting impairments. Taken together, these results suggest that heavy cannabis use can disrupt timing-related synaptic plasticity within the cerebellum, even after the cessation of cannabis use. Content Type Journal ArticleCategory Original InvestigationPages 1-9DOI 10.1007/s00213-011-2556-1Authors Adam B. Steinmetz, Department of Psychology, University of Iowa, Iowa City, IA 52242, USAChad R. Edwards, Department of Psychological and Brain Sciences, Indiana University, 1101 E. 10th St., Bloomington, IN 47405, USAJennifer M. Vollmer, Department of Psychiatry, Yale University School of Medicine, 300 George St., ... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5474622 Thu, 01 Dec 2011 19:30:06 +0100 5474622 http://www.medworm.com/index.php?rid=5474623&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp372167088688701%2F Conclusion  The research reviewed here suggests that discrimination reversal learning may be used as a diagnostic tool for investigating the neural mechanisms that mediate impulsive and compulsive aspects of pathological reward-seeking and -taking behaviors. Two interrelated mechanisms are posited for the neuroadaptations in addiction that often translate to poor reversal learning: frontocorticostriatal circuitry dysregulation and poor dopamine (D2 receptor) modulation of this circuitry. These data suggest new approaches to targeting inhibitory control mechanisms in addictions. Content Type Journal ArticleCategory ReviewPages 1-14DOI 10.1007/s00213-011-2579-7Authors Alicia Izquierdo, Department of Psychology, California State University, Los Angeles, 5151 State Uni... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5474623 Thu, 01 Dec 2011 19:30:05 +0100 5474623 http://www.medworm.com/index.php?rid=5467050&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F5160p4v268u1v264%2F Conclusions  Results showed that alprazolam induced changes in terms of uncoupling between regions of the scalp, with opposite trends depending on the variables: decrease in linear ones and increase in nonlinear features. Maps provided consistent information about the way brain changed in terms of connectivity being definitely necessary to evaluate separately linear and nonlinear interactions. Content Type Journal ArticleCategory Original InvestigationPages 1-10DOI 10.1007/s00213-011-2587-7Authors J. F. Alonso, Department of Automatic Control (ESAII), Biomedical Engineering Research Centre (CREB), Universitat Politècnica de Catalunya (UPC), Carrer Pau Gargallo 5, 08028 Barcelona, SpainM. A. Mañanas, Department of Automatic Control (ESAII), Biomedical Engineering Re... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5467050 Wed, 30 Nov 2011 04:39:28 +0100 5467050 http://www.medworm.com/index.php?rid=5467049&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd3564q04115n6q08%2F Conclusions  The results suggest: 1) TC-2153 as a new drug with potential psychotropic and anticataleptic activities and 2) the involvement of BDNF and gp130 in the molecular mechanism of TC-2153 action. Content Type Journal ArticleCategory Original InvestigationPages 1-10DOI 10.1007/s00213-011-2594-8Authors Alexander V. Kulikov, Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, 630090 RussiaMaria A. Tikhonova, Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, 630090 RussiaElizabeth A. Kulikova, Novosibirsk State University, Novosibirsk, 630090 RussiaKonstantin P. Volcho, Novosibirsk Institute of Organic Chemistry, Siberian Branch of Russian Academy of Sciences, Novosibirsk, ... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5467049 Wed, 30 Nov 2011 04:39:28 +0100 5467049 http://www.medworm.com/index.php?rid=5467052&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq437666ut78rq802%2F Conclusions  Taken together, these novel findings suggest that negative modulation of GABAA α5 receptors may represent an attractive treatment option for the cognitive impairments, and potentially positive symptoms, associated with schizophrenia. Content Type Journal ArticleCategory Original InvestigationPages 1-18DOI 10.1007/s00213-011-2593-9Authors John P. Redrobe, Synaptic Transmission I, Neuroscience Research DK, H. Lundbeck A/S, Ottiliavej 9, 2500 Valby, DenmarkLisbeth Elster, Neuroscience Research DK, H. Lundbeck A/S, Ottiliavej 9, 2500 Valby, DenmarkKristen Frederiksen, Neuroscience Research DK, H. Lundbeck A/S, Ottiliavej 9, 2500 Valby, DenmarkChristoffer Bundgaard, Neuroscience Research DK, H. Lundbeck A/S, Ottiliavej 9, 2500 Valby, DenmarkInge E. M. de Jong... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5467052 Tue, 29 Nov 2011 22:22:03 +0100 5467052 http://www.medworm.com/index.php?rid=5467051&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F1414541t28348477%2F Content Type Journal ArticleCategory EditorialPages 1-2DOI 10.1007/s00213-011-2584-xAuthors TW Robbins, Behavioural and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Cambridge, UKHV Curran, Clinical Psychopharmacology Unit, Research Department of Clinical, Health and Educational Psychology, University College London, Gower St., London, WC1E 6BT UKH de Wit, Human Behavioral Pharmacology Laboratory, University of Chicago, 5841 S. Maryland Avenue, 60637 Chicago, IL, USA Journal PsychopharmacologyOnline ISSN 1432-2072Print ISSN 0033-3158 (Source: Psychopharmacology) Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5467051 Tue, 29 Nov 2011 22:22:03 +0100 5467051 http://www.medworm.com/index.php?rid=5467053&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F04220868lq2ln680%2F Conclusions  Drug-induced loss of inhibitory control may be critically involved both in the initial and later stages of addiction. Neuroadaptations occurring during chronic exposure to and/or withdrawal from nicotine render animals more sensitive to the disinhibitory effects of the drug. Longer-term changes in behaviour may play an important role in the increased susceptibility to relapse in those with a history of nicotine abuse. Content Type Journal ArticleCategory Original InvestigationPages 1-16DOI 10.1007/s00213-011-2558-zAuthors K. Z. Kolokotroni, Behavioural Neuroscience Laboratory, Institute of Psychological Sciences, University of Leeds, Leeds, LS2 9JT UKR. J. Rodgers, Behavioural Neuroscience Laboratory, Institute of Psychological Sciences, University of L... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5467053 Tue, 29 Nov 2011 22:22:01 +0100 5467053 http://www.medworm.com/index.php?rid=5455309&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9154342r394nj617%2F Conclusions  The administration of levodopa showed no effect on the LDAEP. These findings are in line with other trials using dopamine receptor agonists. Content Type Journal ArticleCategory Original InvestigationPages 1-8DOI 10.1007/s00213-011-2586-8Authors K. Hitz, Department of General Social Psychiatry, University of Zurich, Zurich, SwitzerlandK. Heekeren, Department of General Social Psychiatry, University of Zurich, Zurich, SwitzerlandC. Obermann, Department of General Social Psychiatry, University of Zurich, Zurich, SwitzerlandT. Huber, Internal Medicine, Psychiatric University Hospital Zurich, Zurich, SwitzerlandG. Juckel, Department of Psychiatry, Ruhr-University Bochum, Bochum, GermanyW. Kawohl, Department of General Social Psychiatry, University of Zurich, ... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5455309 Fri, 25 Nov 2011 17:56:32 +0100 5455309 http://www.medworm.com/index.php?rid=5455310&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F7416j845u14110j8%2F Conclusion  These data improve our understanding of the basic neuropharmacology of a visual discrimination in cognitive tests employing touchscreens and will aid in the interpretation of pharmacological studies with more cognitively demanding methodologies. Content Type Journal ArticleCategory Original InvestigationPages 1-13DOI 10.1007/s00213-011-2590-zAuthors J. C. Talpos, Janssen Pharmaceutical Companies of Johnson & Johnson, Turnhoutseweg 30, Beerse, B2340 BelgiumA. C. Fletcher, Lilly Research Laboratories, Eli Lilly & Co. Ltd, Erl Wood Manor, Sunninghill Road, Windlesham, Surrey GU20 6PH, UKC. Circelli, Lilly Research Laboratories, Eli Lilly & Co. Ltd, Erl Wood Manor, Sunninghill Road, Windlesham, Surrey GU20 6PH, UKM. D. Tricklebank, Lilly Research Laboratories,... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5455310 Fri, 25 Nov 2011 06:43:53 +0100 5455310 http://www.medworm.com/index.php?rid=5455311&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr82301j7p3h37070%2F Abstract Rationale  Drug-related cues can elicit approach responses in drug users. However, no relevant research has ever concerned heroin abusers. In the present study, we investigated whether the abstinent heroin abusers demonstrated special behavioural tendencies to approach or avoid the drug-related stimuli compared with neutral stimuli. Method  Twenty-two male abstinent heroin abusers (AH) and 20 healthy males (NC) were tested by a Pull/Push Task. Participants pulled (approach response) or pushed (avoidance response) a lever in response to the content of stimulus pictures (i.e. heroin-related versus neutral). The approach and avoidance scores were therefore calculated based on response times and directions to reflect their behavioural tendencies. ... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5455311 Thu, 24 Nov 2011 06:50:17 +0100 5455311 http://www.medworm.com/index.php?rid=5455312&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F01120346hj636x88%2F Conclusions  SIP represents an animal model of non-regulatory and excessive drinking that may be valid for studying the psychopharmacology of the compulsive phenotype and modeling different psychopathologies from compulsivity spectrum disorders. Content Type Journal ArticleCategory ReviewPages 1-13DOI 10.1007/s00213-011-2570-3Authors Margarita Moreno, Departmento de Neurociencia y Ciencias de la Salud, Universidad de Almería, Carretera de Sacramento s/n, La Cañada de San Urbano, 04120 Almeria, SpainPilar Flores, Departmento de Neurociencia y Ciencias de la Salud, Universidad de Almería, Carretera de Sacramento s/n, La Cañada de San Urbano, 04120 Almeria, Spain Journal PsychopharmacologyOnline ISSN 1432-2072Print ISSN 0033-3158 (Source: Psychopharmacology) Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5455312 Wed, 23 Nov 2011 17:36:22 +0100 5455312 http://www.medworm.com/index.php?rid=5455313&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx63517347j876718%2F Conclusions  These findings show that HD rats selected by SIP exhibit compulsive and impulsive behaviour based on measures of performance on the five-choice serial reaction time task and associated with changes in monoaminergic systems in limbic–striatal circuitry. Content Type Journal ArticleCategory Original InvestigationPages 1-12DOI 10.1007/s00213-011-2575-yAuthors Margarita Moreno, Departamento de Neurociencia y Ciencias de la Salud, Universidad de Almería, Carretera de Sacramento s/n, La Cañada de San Urbano, 04120 Almería, SpainValeria Edith Gutiérrez-Ferre, Departamento de Neurociencia y Ciencias de la Salud, Universidad de Almería, Carretera de Sacramento s/n, La Cañada de San Urbano, 04120 Almería, SpainLuis Ruedas, Departamento de Neurociencia y Ci... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5455313 Wed, 23 Nov 2011 17:36:21 +0100 5455313 http://www.medworm.com/index.php?rid=5455315&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6t1358r048573487%2F Conclusion  We provided a comprehensive analysis of behavioral, neurobiochemical, and transcriptome data across 30 mouse inbred strains that has not been accomplished before. We identified biomarkers that influence fluoxetine response, which, altogether, implicate the importance of cellular genesis in fluoxetine treatment. More broadly, this approach can be used to assess a wide range of drug response phenotypes that are challenging to address in human samples. Content Type Journal ArticleCategory Original InvestigationPages 1-19DOI 10.1007/s00213-011-2574-zAuthors Cristina S. Benton, Division of Pharmacotherapy and Experimental Therapeutics, University of North Carolina at Chapel Hill, Genetic Medicine Building, 120 Mason Farm Road, Chapel Hill, NC 27599, USABrooke... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5455315 Wed, 23 Nov 2011 17:36:20 +0100 5455315 http://www.medworm.com/index.php?rid=5455314&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn14140308542vhl7%2F Conclusions  It is suggested that in the dorsal striatum, 5-HT by an action on 5-HT2A and 5-HT2C receptors may integrate the glutamate corticostriatal inputs critical for different aspects of the 5-CSRT task performance. Content Type Journal ArticleCategory Original InvestigationPages 1-13DOI 10.1007/s00213-011-2581-0Authors Laura Agnoli, Department of Neuroscience, Istituto di Ricerche Farmacologiche “Mario Negri”, via G. La Masa 19, Milan, 20156 ItalyMirjana Carli, Department of Neuroscience, Istituto di Ricerche Farmacologiche “Mario Negri”, via G. La Masa 19, Milan, 20156 Italy Journal PsychopharmacologyOnline ISSN 1432-2072Print ISSN 0033-3158 (Source: Psychopharmacology) Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5455314 Wed, 23 Nov 2011 17:36:20 +0100 5455314 http://www.medworm.com/index.php?rid=5455316&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr7402u5041286344%2F Conclusions  Our findings suggest that the NMDA receptor glycine modulatory site in the VTA plays a major role in cocaine reward memory, and NMDA receptor glycine site antagonists may be potential pharmacotherapies for the management of relapse. Content Type Journal ArticleCategory Original InvestigationPages 1-11DOI 10.1007/s00213-011-2551-6Authors Shuang-jiang Zhou, Insititute of Mental Health, Hebei Medical University, Shijiazhuang, 050031 ChinaLi-fen Xue, National Institute on Drug Dependence, Peking University, 38 Xueyuan Road, Beijing, 100191 ChinaXue-yi Wang, Insititute of Mental Health, Hebei Medical University, Shijiazhuang, 050031 ChinaWen-gao Jiang, National Institute on Drug Dependence, Peking University, 38 Xueyuan Road, Beijing, 100191 ChinaYan-xue Xue, ... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5455316 Tue, 22 Nov 2011 06:57:45 +0100 5455316 http://www.medworm.com/index.php?rid=5438990&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk200721xq5816h67%2F Content Type Journal ArticleCategory CommentaryPages 1-2DOI 10.1007/s00213-011-2583-yAuthors Paolo Bellavite, Department of Pathology and Diagnostics, University of Verona, Verona, ItalyPaolo Magnani, Department of Pathology and Diagnostics, University of Verona, Verona, ItalyAnita Conforti, Department of Medicine and Public Health, University of Verona, Verona, ItalyMarta Marzotto, Department of Pathology and Diagnostics, University of Verona, Verona, ItalyMariaelisabetta Zanolin, Department of Medicine and Public Health, University of Verona, Verona, Italy Journal PsychopharmacologyOnline ISSN 1432-2072Print ISSN 0033-3158 (Source: Psychopharmacology) Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5438990 Mon, 21 Nov 2011 06:32:41 +0100 5438990 http://www.medworm.com/index.php?rid=5438989&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F4941672028m753j1%2F Conclusion  Our findings suggest that two sessions of Exp/RP combined with DCS does not enhance the reduction in episodic cue reactivity in non-treatment seeking smokers. A trend towards a greater sustained reduction in the emotionality scale of the TCQ in the DCS group suggests that further detailed study of the effects of combined Exp/RP-DCS on different aspects of craving is warranted, especially in smokers with a current intention to quit. Content Type Journal ArticleCategory Original InvestigationPages 1-12DOI 10.1007/s00213-011-2571-2Authors Sunjeev K. Kamboj, Clinical Psychopharmacology Unit, Research Department of Clinical, Educational and Health Psychology, University College London, Gower Street, London, WC1E 6BT UKAlyssa Joye, Clinical Psychopharmacology ... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5438989 Mon, 21 Nov 2011 06:32:41 +0100 5438989 http://www.medworm.com/index.php?rid=5429638&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj533g06780849620%2F Conclusions  These findings implicate glutamatergic and GABAergic mechanisms in the IL in the expression of impulsivity and suggest that excessive glutamate release may not underlie increased impulsivity induced by local NMDA receptor antagonism. Content Type Journal ArticleCategory Original InvestigationPages 1-10DOI 10.1007/s00213-011-2572-1Authors Emily R. Murphy, Behavioural and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB UKAnushka B. P. Fernando, Behavioural and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB UKGonzalo P. Urcelay, Behavioural and Clinical Neuroscience Institute and Depart... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5429638 Fri, 18 Nov 2011 17:28:19 +0100 5429638 http://www.medworm.com/index.php?rid=5429639&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fru43n4u1156802qh%2F Conclusions  The current findings are consistent with recent theoretical work that characterises 5-HT as pruning a tree of potential decisions, eliminating options expected to lead to aversive outcomes. Our results extend this account by proposing that 5-HT promotes reflexive avoidance of relatively immediate aversive outcomes, potentially at the expense of more globally construed future losses. Content Type Journal ArticleCategory Original InvestigationPages 1-11DOI 10.1007/s00213-011-2577-9Authors M. J. Crockett, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, England, UKL. Clark, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, England, UKL. D. Smillie, Psychological Sciences, The University... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5429639 Fri, 18 Nov 2011 06:56:55 +0100 5429639 http://www.medworm.com/index.php?rid=5429640&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9p8581q449744015%2F Content Type Journal ArticleCategory Letter to the EditorsPages 1-2DOI 10.1007/s00213-011-2582-zAuthors Luigi Cervo, Laboratory of Experimental Psychopharmacology, Department of Neuroscience, “Mario Negri” Institute for Pharmacological Research, Via La Masa 19, 20156 Milan, ItalyValter Torri, Laboratory of New Drug Development Strategies, Department of Oncology, “Mario Negri” Institute for Pharmacological Research, Via La Masa 19, 20156 Milan, Italy Journal PsychopharmacologyOnline ISSN 1432-2072Print ISSN 0033-3158 (Source: Psychopharmacology) Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5429640 Fri, 18 Nov 2011 06:56:53 +0100 5429640 http://www.medworm.com/index.php?rid=5429641&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6v0835t262784613%2F Conclusions  The 5CSRTT has proven to be a useful tool to investigate impulsivity in mice. Content Type Journal ArticleCategory ReviewPages 1-18DOI 10.1007/s00213-011-2560-5Authors Sandra Sanchez-Roige, School of Psychology, University of Sussex, Falmer, Brighton, BN1 9QG UKYolanda Peña-Oliver, School of Psychology, University of Sussex, Falmer, Brighton, BN1 9QG UKDavid N. Stephens, School of Psychology, University of Sussex, Falmer, Brighton, BN1 9QG UK Journal PsychopharmacologyOnline ISSN 1432-2072Print ISSN 0033-3158 (Source: Psychopharmacology) Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5429641 Thu, 17 Nov 2011 07:01:00 +0100 5429641 http://www.medworm.com/index.php?rid=5429643&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl2h08m0065138702%2F Conclusions  Our findings suggest that nicotine regulates PD expression in striatum at the transcriptional level and CREB is involved. Dopamine D1 receptor stimulation by nAChR-released dopamine appears to be an underlying mechanism. Altered Dyn synthesis might be relevant for the behavioral actions of nicotine and especially its aversive properties. Content Type Journal ArticleCategory Original InvestigationPages 1-11DOI 10.1007/s00213-011-2559-yAuthors Michael J. McCarthy, Department of Psychiatry, The Ohio State University College of Medicine, Columbus, OH 43210, USAAnne-Marie Duchemin, Department of Psychiatry, The Ohio State University College of Medicine, Columbus, OH 43210, USANorton H. Neff, Department of Psychiatry, The Ohio State University College of Medic... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5429643 Wed, 16 Nov 2011 06:50:35 +0100 5429643 http://www.medworm.com/index.php?rid=5429642&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fvj2014893858675n%2F Conclusion  The contrasting effects of repeated methylphenidate treatment in methylphenidate self-administration and reinstatement in Wistar and SHR, and the increased susceptibility of the Wistar rat strain to the reinforcing effects of methylphenidate indicate that “normal” individuals are more likely to develop psychological dependence to the drug and experience relapse. Meanwhile, the clinical use of methylphenidate may not produce drug dependence or relapse in ADHD patients. Content Type Journal ArticleCategory Original InvestigationPages 1-10DOI 10.1007/s00213-011-2564-1Authors Ike dela Peña, Uimyung Research Institute for Neuroscience, Sahmyook University, 26-21 Kongreung-dong, Nowon-gu, Seoul 139-742, KoreaSeo Young Yoon, Uimyung Research Institute for ... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5429642 Wed, 16 Nov 2011 06:50:35 +0100 5429642 http://www.medworm.com/index.php?rid=5419933&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm5714285886736p5%2F Conclusion  Chronic administration of CBD produced an anxiogenic-like effect in clear opposition to the acute anxiolytic profile previously reported. In addition, CBD decreased the expression of proteins that have been shown to be enhanced by chronic treatment with antidepressant/anxiolytic drugs. Content Type Journal ArticleCategory Original InvestigationPages 1-9DOI 10.1007/s00213-011-2566-zAuthors Maha M. ElBatsh, School of Biomedical Sciences, University of Nottingham Medical School, Queen’s Medical Centre, Nottingham, NG7 2UH UKN. Assareh, School of Biomedical Sciences, University of Nottingham Medical School, Queen’s Medical Centre, Nottingham, NG7 2UH UKC. A. Marsden, School of Biomedical Sciences, University of Nottingham Medical School, Queen’s Medical... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5419933 Mon, 14 Nov 2011 16:52:53 +0100 5419933 http://www.medworm.com/index.php?rid=5419934&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl4g6w44136w5n482%2F Conclusions  Brief exposure to environmental events hypothesized to be stressors or enrichment altered cocaine choice, although not all individuals were affected and the effects were transient. Importantly, the data suggest that implementing positive changes in the environment produced effects that are clinically desirable. Understanding the behavioral and neurobiological mechanisms mediating sensitivity to environmental events in socially housed animals will lead to better treatment strategies for drug addiction. Content Type Journal ArticleCategory Original InvestigationPages 1-11DOI 10.1007/s00213-011-2562-3Authors Paul W. Czoty, Department of Physiology and Pharmacology, School of Medicine, Wake Forest University, Medical Center Blvd., 546 NRC, Winston-Salem, N... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5419934 Mon, 14 Nov 2011 16:52:52 +0100 5419934 http://www.medworm.com/index.php?rid=5405241&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F3401m7406889123k%2F Conclusions  The dissociation between subjective perceptions and objective performance decrements are important notions for traffic safety since this may affect a driver’s judgement of whether or not it is safe to drive. For example, an intoxicated individual might decide to drive because the feelings of alertness caused by MDMA cloud the impairing effects of other drugs such as alcohol, thereby creating a potentially serious risk for traffic safety. Content Type Journal ArticleCategory Original InvestigationPages 1-14DOI 10.1007/s00213-011-2537-4Authors Janet L. Veldstra, Department of Neuropsychology, University of Groningen, Grote Kruisstraat 2/1, 9712 TS Groningen, the NetherlandsKarel A. Brookhuis, Department of Neuropsychology, University of Groningen, Grote... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5405241 Thu, 10 Nov 2011 16:56:11 +0100 5405241 http://www.medworm.com/index.php?rid=5405240&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb078003418326107%2F Conclusion  Single doses of 0.8 g/kg alcohol increased risk-taking behaviours and impaired tracking, attention and reaction time during a 3-h period after drinking when BACs declined from 0.9 to 0.2 mg/ml. The stimulatory effects of co-administration of dexamphetamine 10 mg were not sufficient to overcome the impairing effects of alcohol on skills related to driving. Content Type Journal ArticleCategory Original InvestigationPages 1-9DOI 10.1007/s00213-011-2549-0Authors Ries Simons, Department of Behavioral and Social Sciences, TNO Netherlands Organization for Applied Scientific Research, P.O. Box 23, 3769 ZG Soesterberg, NetherlandsMarieke Martens, Department of Behavioral and Social Sciences, TNO Netherlands Organization for Applied Scientific Resear... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5405240 Thu, 10 Nov 2011 16:56:11 +0100 5405240 http://www.medworm.com/index.php?rid=5405243&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F1353gt1l558g0v63%2F Content Type Journal ArticleCategory Letter to the EditorsPages 1-1DOI 10.1007/s00213-011-2546-3Authors Francesco Angelucci, Department of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, 00179 Rome, ItalyCarlo Caltagirone, Department of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, 00179 Rome, ItalyValerio Ricci, Department of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, 00179 Rome, Italy Journal PsychopharmacologyOnline ISSN 1432-2072Print ISSN 0033-3158 (Source: Psychopharmacology) Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5405243 Wed, 09 Nov 2011 07:06:13 +0100 5405243 http://www.medworm.com/index.php?rid=5405242&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh0060736k3775vg6%2F Conclusions  While SOR is not without its limitations, the task represents a useful method for studying manipulations with relevance to cognitive impairment in schizophrenia, as well as the interactions between them. Content Type Journal ArticleCategory ReviewPages 1-26DOI 10.1007/s00213-011-2536-5Authors L. Lyon, Department of Experimental Psychology, University of Cambridge, Downing St, Cambridge, CB2 3EB UKL. M. Saksida, Department of Experimental Psychology, University of Cambridge, Downing St, Cambridge, CB2 3EB UKT. J. Bussey, Department of Experimental Psychology, University of Cambridge, Downing St, Cambridge, CB2 3EB UK Journal PsychopharmacologyOnline ISSN 1432-2072Print ISSN 0033-3158 (Source: Psychopharmacology) Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5405242 Wed, 09 Nov 2011 07:06:13 +0100 5405242 http://www.medworm.com/index.php?rid=5405244&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr7l6r431jj185475%2F Conclusions  Our results suggest that the AMPA-PAMs, when compared to the GlyT-1 inhibitor, show differential effects in terms of augmentation of antipsychotic efficacy, particularly when combined with risperidone or olanzapine. Both AMPA-PAMs and the GlyT-1 inhibitor may also improve negative symptoms and cognitive impairments in schizophrenia, in particular when combined with risperidone. Content Type Journal ArticleCategory Original InvestigationPages 1-17DOI 10.1007/s00213-011-2554-3Authors Kent Jardemark, Department of Physiology and Pharmacology, The Karolinska Institutet, Stockholm, SwedenMonica M. Marcus, Department of Physiology and Pharmacology, The Karolinska Institutet, Stockholm, SwedenAnna Malmerfelt, Department of Physiology and Pharmacology, The Karol... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5405244 Tue, 08 Nov 2011 16:49:36 +0100 5405244 http://www.medworm.com/index.php?rid=5398414&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj5l4842203737426%2F Conclusions  Both similarities and differences exist between PG and SUDs. Understanding these similarities more precisely may facilitate treatment development across addictions, whereas understanding differences may provide insight into treatment development for specific disorders. Individual differences in features of impulsivity and compulsivity may represent important endophenotypic targets for prevention and treatment strategies. Content Type Journal ArticleCategory ReviewPages 1-22DOI 10.1007/s00213-011-2550-7Authors Robert F. Leeman, Department of Psychiatry, Yale University School of Medicine, CMHC, 34 Park Street, New Haven, CT 06405, USAMarc N. Potenza, Department of Psychiatry, Yale University School of Medicine, CMHC, 34 Park Street, New Haven, CT 06405, ... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5398414 Sat, 05 Nov 2011 15:44:40 +0100 5398414 http://www.medworm.com/index.php?rid=5398413&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F37201302353v0100%2F Conclusions  Inhibitory capacity was more precisely estimated from FMI than from DRL performance. Based on FMI data, MPH, but not a socially enriched environment, appears to improve inhibitory capacity. The highest dose of MPH tested, 8 mg/kg, did not reduce inhibitory capacity but reduced the responsiveness to waiting contingencies. These results support the use of the FMI schedule, complemented with appropriate analytic techniques, for the assessment of behavioral inhibition in animal models. Content Type Journal ArticleCategory Original InvestigationPages 1-10DOI 10.1007/s00213-011-2552-5Authors Jade C. Hill, Arizona State University, Tempe, AZ, USAPablo Covarrubias, University of Guadalajara-CUCI, Ocotlan, MexicoJoel Terry, University of Nevada, Las Vegas, ... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5398413 Sat, 05 Nov 2011 15:44:40 +0100 5398413 http://www.medworm.com/index.php?rid=5398415&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F2u0q758163u11386%2F Content Type Journal ArticleCategory ErratumPages 1-1DOI 10.1007/s00213-011-2547-2Authors Lior Greenbaum, Biological Psychiatry Laboratory, Department of Psychiatry, Hadassah–Hebrew University Medical Center, Ein Karem, Jerusalem, 91120 IsraelRobert C. Smith, Department of Psychiatry, New York University Medical School, New York, NY, USAMordechai Lorberboym, Department of Nuclear Medicine, Edith Wolfson Medical Center, Holon, IsraelAnna Alkelai, Biological Psychiatry Laboratory, Department of Psychiatry, Hadassah–Hebrew University Medical Center, Ein Karem, Jerusalem, 91120 IsraelPolina Zozulinsky, Biological Psychiatry Laboratory, Department of Psychiatry, Hadassah–Hebrew University Medical Center, Ein Karem, Jerusalem, 91120 IsraelTzuri Lifschytz, Biological Psychiatry Laborato... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5398415 Sat, 05 Nov 2011 15:44:39 +0100 5398415 http://www.medworm.com/index.php?rid=5398416&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq305783w7t194n72%2F This study examined the relationship between fMRI activation and magnitude of dopamine release measured with Positron emission tomography study (PET) in the same subjects using MIDT in both modalities to test if fMRI activation is related to dopamine release. Eighteen healthy subjects were scanned with [11 C]raclopride PET at baseline and after MIDT. Binding potential (BPND) was derived by equilibrium analysis in striatal subregions and percent change across conditions (∆BPND) was measured. Blood oxygen level dependence (BOLD) signal changes with MIDT were measured during fMRI using voxelwise analysis and ROI analysis and correlated with ∆BPND. ∆BPND was not significant in the ventral striatum (VST) but reached significance in the posterior caudate. The fMRI BOLD act... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5398416 Fri, 04 Nov 2011 05:44:12 +0100 5398416 http://www.medworm.com/index.php?rid=5378629&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6w431x3x879t9518%2F Conclusions  Familial vulnerability to schizophrenia reduces P50 amplitude. Nicotinic modulation of this deficit mirrors the effect of nicotine during smoking abstinence and suggests an “inverted-U” relationship between P50 amplitude and endogenous nicotinic activity. P50 amplitude may, therefore, be a sensitive marker of nicotinic dysfunction in individuals with familial risk for schizophrenia, which is mediated through mechanisms (e.g., α4β2 receptors) that are distinct from those (e.g., α7 receptors) that mediate P50 gating. Content Type Journal ArticleCategory Original InvestigationPages 1-14DOI 10.1007/s00213-011-2544-5Authors Bruce I. Turetsky, Department of Psychiatry, University of Pennsylvania, 10th Floor, Gates Building, 3400 Spruce Street, Philadel... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5378629 Wed, 02 Nov 2011 16:59:04 +0100 5378629 http://www.medworm.com/index.php?rid=5378628&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fehvlt62780719038%2F Conclusion  These results demonstrate that post-retrieval extinction training can either improve or impair CPP extinction depending on the retrieval-extinction interval. Content Type Journal ArticleCategory Original InvestigationPages 1-8DOI 10.1007/s00213-011-2545-4Authors Xiang Ma, Laboratory of Neurobiology and State Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, Peking University, Beijing, 100871 People’s Republic of ChinaJian-Jun Zhang, Laboratory of Neurobiology and State Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, Peking University, Beijing, 100871 People’s Republic of ChinaLong-Chuan Yu, Laboratory of Neurobiology and State Key Laboratory of Biomembrane and Membrane Biotechnology,... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5378628 Wed, 02 Nov 2011 16:59:04 +0100 5378628 http://www.medworm.com/index.php?rid=5378631&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc34j7r742n441246%2F Conclusions  These data provide evidence that MDMA has time of day dependent actions on SCN functioning, as evident from its induction of core clock genes that are important for generating and maintaining circadian rhythmicity. Content Type Journal ArticleCategory Original InvestigationPages 1-9DOI 10.1007/s00213-011-2541-8Authors Rowan P. Ogeil, School of Psychology and Psychiatry, Monash University, Clayton, Victoria 3800, AustraliaDavid J. Kennaway, Robinson Institute, Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, University of Adelaide, Adelaide, South Australia 5005, AustraliaMark D. Salkeld, Robinson Institute, Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, University of Adelaide, Adelaide,... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5378631 Fri, 28 Oct 2011 16:56:52 +0100 5378631 http://www.medworm.com/index.php?rid=5378630&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv3015j47754331r0%2F Conclusions  These results validate the use of animals with elevated brain kynurenic acid levels in SZ research and support studies of drugs that normalize brain kynurenic acid levels and/or positively modulate α7nAChRs as pro-cognitive treatments for SZ. Content Type Journal ArticleCategory Original InvestigationPages 1-11DOI 10.1007/s00213-011-2539-2Authors Kathleen S. Alexander, Department of Psychology and Neuroscience, The Ohio State University, 1835 Neil Ave., Columbus, OH 43210, USAHui-Qiu Wu, Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21228, USARobert Schwarcz, Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5378630 Fri, 28 Oct 2011 16:56:52 +0100 5378630 http://www.medworm.com/index.php?rid=5378632&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F48174x51216p6w48%2F Conclusions  The present results demonstrate the importance of baseline performance differences for the effectiveness of pharmacological enhancement of cognitive control. More generally, the results suggest that stimulation of the nicotinic acetylcholine receptor system might be an effective way of improving cognition in people with poor cognitive performance, such as patients with ADHD or schizophrenia. Content Type Journal ArticleCategory Original InvestigationPages 1-12DOI 10.1007/s00213-011-2540-9Authors Nadine Petrovsky, Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, GermanyUlrich Ettinger, Department of Psychiatry, Ludwig-Maximilians-University Munich, Munich, GermanyBoris B. Quednow, Division of Experimental... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5378632 Fri, 28 Oct 2011 16:56:51 +0100 5378632 http://www.medworm.com/index.php?rid=5378634&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb0260h0167057837%2F Conclusions  When given in combination with either a typical or atypical antipsychotic, α7 nAChR agonists did not impair efficacy in the DBA/2 J mouse PPI model. The efficacy but not the motoric side effects of antipsychotics was enhanced, suggesting that adjunctive therapy of α7 nAChR agonists not only could be useful for the treatment of cognitive deficits associated with schizophrenia but also could enhance the efficacy against positive symptoms. Content Type Journal ArticleCategory Original InvestigationPages 1-11DOI 10.1007/s00213-011-2535-6Authors Kathy L. Kohlhaas, Neuroscience Research, Global Pharmaceutical Research & Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064-6115, USARobert S. Bitner, Neuroscience Research, Global... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5378634 Fri, 28 Oct 2011 16:56:49 +0100 5378634 http://www.medworm.com/index.php?rid=5378633&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft61m0554437076l8%2F Conclusions  Neuropathic pain is not accompanied by modifications in tonic LC activity after the onset of pain. This may indicate that the signals from the PGi and DRN, the excitatory and inhibitory afferents of the LC, cancel one another out. Content Type Journal ArticleCategory Original InvestigationPages 1-13DOI 10.1007/s00213-011-2542-7Authors Cristina Alba-Delgado, Neuropsychopharmacology Research Group, Department of Neuroscience, University of Cadiz, 11003 Cadiz, SpainGisela Borges, Neuropsychopharmacology Research Group, Department of Neuroscience, University of Cadiz, 11003 Cadiz, SpainPilar Sánchez-Blázquez, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, SpainJorge E. Ortega, Centro de Investig... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5378633 Fri, 28 Oct 2011 16:56:49 +0100 5378633 http://www.medworm.com/index.php?rid=5345107&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu27672x5005rj2m3%2F Conclusions  Further research into the acute effects of amphetamine preparations is necessary to further quantify the acute disruption of aspects of human functioning crucial to complex activities such as attention, selective memory, and psychomotor performance. Content Type Journal ArticleCategory Original InvestigationPages 1-9DOI 10.1007/s00213-011-2532-9Authors Con Stough, Centre for Human Psychopharmacology, Swinburne University of Technology, Hawthorn, VIC 3122, AustraliaRebecca King, Centre for Human Psychopharmacology, Swinburne University of Technology, Hawthorn, VIC 3122, AustraliaKatherine Papafotiou, Centre for Human Psychopharmacology, Swinburne University of Technology, Hawthorn, VIC 3122, AustraliaPhillip Swann, Centre for Human Psychopharmacology, Swin... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5345107 Fri, 21 Oct 2011 16:00:09 +0100 5345107 http://www.medworm.com/index.php?rid=5345108&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq2144l6661p1p087%2F Conclusion  Both in vivo and in vitro data indicate that i.v. heroin SA induces the synthesis of M6G. These data are discussed in the light of previous studies conducted in heroin addicts indicating that in humans heroin enhances the synthesis of the active metabolite of heroin and morphine. Content Type Journal ArticleCategory Original InvestigationPages 1-9DOI 10.1007/s00213-011-2534-7Authors Maria Meringolo, Department of Physiology and Pharmacology Vittorio Erspamer, Sapienza University of Rome, Rome, ItalyValentina Brusadin, Drug Addiction and Clinical Pharmacology Unit, University Hospital Policlinico Umberto I, Sapienza University of Rome, Rome, ItalyMaria T. De Luca, Department of Physiology and Pharmacology Vittorio Erspamer, Sapienza University of Rome, Rom... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5345108 Thu, 20 Oct 2011 15:52:33 +0100 5345108 http://www.medworm.com/index.php?rid=5345109&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F8174701x884650j2%2F Conclusions  These findings present a possible behavioral mechanism for escalated alcohol drinking during episodes of heightened elevations in glucocorticoids (e.g., stress). That is, during these episodes, individuals may consume more alcohol to achieve the desired interoceptive effects. Understanding these behavioral mechanisms may lead to a better understanding of factors that promote alcoholism and alcohol abuse in at risk populations. Content Type Journal ArticleCategory Original InvestigationPages 1-14DOI 10.1007/s00213-011-2533-8Authors Joyce Besheer, Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Thurston-Bowles Building, CB#7178, Chapel Hill, NC 27599, USAKristen R. Fisher, Bowles Center for Alcohol Studies, University of No... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5345109 Thu, 20 Oct 2011 15:52:32 +0100 5345109 http://www.medworm.com/index.php?rid=5345110&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd48r3h445q2731t1%2F Conclusion  The administration of oxytocin improved participants’ self-perceptions of their personality, at least for certain traits important for social affiliation. Increased positive self-referential processing may be one mechanism by which oxytocin promotes positive social behaviors. Content Type Journal ArticleCategory Original InvestigationPages 1-9DOI 10.1007/s00213-011-2527-6Authors Christopher Cardoso, Centre for Research in Human Development, Concordia University, 7141 Sherbrooke Street West, Montreal, QC H4B 1R6, CanadaMark A. Ellenbogen, Centre for Research in Human Development, Concordia University, 7141 Sherbrooke Street West, Montreal, QC H4B 1R6, CanadaAnne-Marie Linnen, Centre for Research in Human Development, Concordia University, 7141 Sherbrooke... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5345110 Wed, 19 Oct 2011 15:52:45 +0100 5345110 http://www.medworm.com/index.php?rid=5345111&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl48vm34357168872%2F Content Type Journal ArticleCategory Letter to the EditorsPages 1-1DOI 10.1007/s00213-011-2538-3Authors Jianjun Yang, Department of Anesthesiology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, ChinaZhiqiang Zhou, Department of Anesthesiology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, ChinaChun Yang, Department of Anesthesiology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China Journal PsychopharmacologyOnline ISSN 1432-2072Print ISSN 0033-3158 (Source: Psychopharmacology) Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5345111 Tue, 18 Oct 2011 15:56:08 +0100 5345111 http://www.medworm.com/index.php?rid=5332978&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj68266783r3r7485%2F Conclusion  Sixteen weeks ssupplementation with a combined multivitamin, mineral and herbal formula may benefit working memory in elderly women at risk of cognitive decline. Content Type Journal ArticleCategory Original InvestigationPages 1-15DOI 10.1007/s00213-011-2481-3Authors Helen Macpherson, Centre for Human Psychopharmacology, NICM Collaborative Centre for Neurocognition, Swinburne University of Technology, 427-451 Burwood Road, Hawthorn, Melbourne, VIC 3122, AustraliaKathryn A. Ellis, Department of Psychiatry, Academic Unit for Psychiatry of Old Age, St Vincent’s Aged Psychiatry Service, St George’s Hospital, University of Melbourne, Melbourne, VIC 3101, AustraliaAvni Sali, National Institute of Integrative Medicine, 759 Burwood Road, Hawthorn East, Melbour... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5332978 Mon, 17 Oct 2011 16:01:45 +0100 5332978 http://www.medworm.com/index.php?rid=5332979&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh54388p711807084%2F Content Type Journal ArticleCategory ErratumPages 1-2DOI 10.1007/s00213-011-2531-xAuthors Merideth A. Addicott, Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 2701, Durham, NC 27708, USADavid A. A. Baranger, Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 2701, Durham, NC 27708, USARachel V. Kozink, Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 2701, Durham, NC 27708, USAMoria J. Smoski, Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 2701, Durham, NC 27708, USAGabriel S. Dichter, Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 2701, Durham, NC 27708, USAF. Joseph McClernon, Department of Psychia... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5332979 Mon, 17 Oct 2011 16:01:44 +0100 5332979 http://www.medworm.com/index.php?rid=5322390&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fmg7t7230g1947p34%2F Conclusion  Linking the pharmacological content of ecstasy sold on the street to subjective experiences contributes to a better understanding of the wide range of subjective effects ascribed to ecstasy and provides a strong rationale for the prolonged endurance of MDMA as the key ingredient of the ecstasy market. Content Type Journal ArticleCategory Original InvestigationPages 1-12DOI 10.1007/s00213-011-2529-4Authors Tibor M. Brunt, Drug Information and Monitoring System, Netherlands Institute of Mental Health and Addiction, Utrecht, The NetherlandsMaarten W. Koeter, Amsterdam Institute for Addiction Research, Academic Medical Center of the University of Amsterdam, Amsterdam, The NetherlandsRaymond J. M. Niesink, Drug Information and Monitoring System, Netherlands In... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5322390 Wed, 12 Oct 2011 16:06:39 +0100 5322390 http://www.medworm.com/index.php?rid=5322391&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv513014495920144%2F Conclusions  Novel stimuli relatively free of demand characteristics can be classically conditioned to intermittent brain exposure of even low alcohol concentrations, permitting imaging studies of conditioned alcohol expectancies. Content Type Journal ArticleCategory Original InvestigationPages 1-11DOI 10.1007/s00213-011-2526-7Authors David A. Kareken, Department of Neurology, Indiana University School of Medicine, 541 Clinical Drive (CL 285), Indianapolis, IN 46202, USANicholas Grahame, Department of Psychology, Indiana University-Purdue University Indianapolis (IUPUI), Indianapolis, IN 46202, USAMario Dzemidzic, Department of Neurology, Indiana University School of Medicine, 541 Clinical Drive (CL 285), Indianapolis, IN 46202, USAMelissa J. Walker, Department of Neu... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5322391 Wed, 12 Oct 2011 16:06:37 +0100 5322391 http://www.medworm.com/index.php?rid=5322392&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fbqx61x2334w23260%2F Conclusions  These studies demonstrate that certain amphetamines impair PA performance in mice and that these impairments may be attributable to specific neurochemical depletions. Content Type Journal ArticleCategory Original InvestigationPages 1-14DOI 10.1007/s00213-011-2504-0Authors Kevin Sean Murnane, Division of Neuropharmacology and Neurologic Diseases, Yerkes National Primate Research Center, Yerkes Imaging Center, 954 Gatewood Road, Atlanta, GA 30322-4250, USAShane Alan Perrine, Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USABrendan James Finton, Division of Neuropharmacology and Neurologic Diseases, Yerkes National Primate Research Center, Yerkes Imaging Center, 954 Gatewood Road, Atlanta, GA 3... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5322392 Wed, 12 Oct 2011 16:06:35 +0100 5322392 http://www.medworm.com/index.php?rid=5322393&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fcv72h076p526vp28%2F Conclusion  Hyperactivation in the frontal executive control network during smoking abstinence may represent a need to recruit additional executive resources to meet task demands. Moreover, abstinence-induced negative affect may disrupt cognitive control neural circuitry during EIP and place additional demands on frontal executive neural resources during cognitive demands when presented with emotionally distracting stimuli. Content Type Journal ArticleCategory Original InvestigationPages 1-12DOI 10.1007/s00213-011-2522-yAuthors Brett Froeliger, Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, 2608 Erwin Road, Lake View Pavilion East Suite 300, Durham, NC 27705-4596, USALeslie Modlin, Department of Psychiatry and Behavioral Sciences, ... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5322393 Tue, 11 Oct 2011 15:50:47 +0100 5322393 http://www.medworm.com/index.php?rid=5322394&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F4674581rp1132277%2F Conclusions  These findings demonstrate that PRX-07034 is a selective 5-HT6 receptor antagonist that may represent a novel treatment for enhancing working memory and cognitive flexibility. Content Type Journal ArticleCategory Original InvestigationPages 1-10DOI 10.1007/s00213-011-2518-7Authors Eric G. Mohler, Department of Psychology, University of Illinois at Chicago, 1007 West Harrison Street, Chicago, IL 60607, USAPhillip M. Baker, Department of Psychology, University of Illinois at Chicago, 1007 West Harrison Street, Chicago, IL 60607, USAKimberly S. Gannon, Epix Pharmaceuticals, Lexington, MA, USASimon S. Jones, Epix Pharmaceuticals, Lexington, MA, USASharon Shacham, Epix Pharmaceuticals, Lexington, MA, USAJohn A. Sweeney, Center for Cognitive Medicine, University... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5322394 Tue, 11 Oct 2011 15:50:46 +0100 5322394 http://www.medworm.com/index.php?rid=5322396&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb2r3586qt53016r3%2F Conclusions  We validated a rodent task of impulsive choice, which eliminates typical energy-homeostasis limitations and, therefore, opens new avenues in the study of impulsivity in preclinical feeding and obesity research. Content Type Journal ArticleCategory Original InvestigationPages 1-10DOI 10.1007/s00213-011-2517-8Authors Angelo Blasio, Laboratory of Addictive Disorders, Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, 72 E Concord St, R-618, Boston, MA 02118, USAAditi R. Narayan, Laboratory of Addictive Disorders, Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, 72 E Concord St, R-618, Boston, MA 02118, USABarbara J. Kaminski, Division of Behavioral Biology, Department... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5322396 Tue, 11 Oct 2011 15:50:44 +0100 5322396 http://www.medworm.com/index.php?rid=5322395&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb450374420837183%2F Conclusions  This is the first study investigating the contribution of 5-HT2A and 5-HT2C receptors on development, expression, and recall of cocaine-induced CPP in the HR–LR model of individual vulnerability to drug abuse. Our results show that SB242084 differentially modulates development and expression of CPP in HR vs. LR rats and suggest that 5-HT2C receptors play a key role in individual differences on cocaine reward-related learning/memory processes. Content Type Journal ArticleCategory Original InvestigationPages 1-10DOI 10.1007/s00213-011-2524-9Authors Nancy Capriles, Molecular and Behavioral Neuroscience Institute, The University of Michigan School of Medicine, 205 Zina Pitcher Place, Ann Arbor, MI 48109-0720, USAStanley Watson, Molecular and Behavioral Neu... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5322395 Tue, 11 Oct 2011 15:50:44 +0100 5322395 http://www.medworm.com/index.php?rid=5322397&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft18722618p0xj507%2F Content Type Journal ArticleCategory Letter to the EditorsPages 1-3DOI 10.1007/s00213-011-2528-5Authors Marina Sagud, Department of Psychiatry, University Hospital Centre Zagreb, School of Medicine, University of Zagreb, Kispaticeva 12, HR-10000 Zagreb, CroatiaMatea Nikolac, Division of Molecular Medicine, Rudjer Boskovic Institute, Bijenicka 54, HR-10000 Zagreb, CroatiaAlma Mihaljevic-Peles, Department of Psychiatry, University Hospital Centre Zagreb, School of Medicine, University of Zagreb, Kispaticeva 12, HR-10000 Zagreb, CroatiaGordana Nedic, Division of Molecular Medicine, Rudjer Boskovic Institute, Bijenicka 54, HR-10000 Zagreb, CroatiaBjanka Vuksan Cusa, Department of Psychiatry, University Hospital Centre Zagreb, School of Medicine, University of Zagreb, Kispaticeva 12, HR-100... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5322397 Tue, 11 Oct 2011 15:50:42 +0100 5322397 http://www.medworm.com/index.php?rid=5322399&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F20433w562562633g%2F Conclusions  This potent cannabinergic HHC exhibited a slow onset of action with a protracted time-course. The AM2389 chemotype appears well suited for further drug development, and AM2389 currently is used to probe behavioral consequences of sustained ECS activation. Content Type Journal ArticleCategory Original InvestigationPages 1-10DOI 10.1007/s00213-011-2491-1Authors Torbjörn U. C. Järbe, Center for Drug Discovery, Department of Pharmaceutical Sciences, Northeastern University, 116 Mugar Hall, 360 Huntington Ave, Boston, MA 02115, USASherrica Tai, Center for Drug Discovery, Department of Pharmaceutical Sciences, Northeastern University, 116 Mugar Hall, 360 Huntington Ave, Boston, MA 02115, USABrian J. LeMay, Center for Drug Discovery, Department of Pharmaceutic... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5322399 Tue, 11 Oct 2011 15:50:40 +0100 5322399 http://www.medworm.com/index.php?rid=5322398&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa2n03j5216386708%2F Conclusions  Both ST(PR) and ST(RI) schedules can be used to assess seeking and taking of sucrose and cocaine. Dopaminergic neurotransmission mediates the positive subjective properties of cocaine but not sucrose and the motivational properties of both sucrose and cocaine. Content Type Journal ArticleCategory Original InvestigationPages 1-15DOI 10.1007/s00213-011-2525-8Authors M. M. J. Veeneman, Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The NetherlandsM. van Ast, Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The NetherlandsM. H. Broekhoven... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5322398 Tue, 11 Oct 2011 15:50:40 +0100 5322398 http://www.medworm.com/index.php?rid=5322400&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh547885616118wwq%2F Conclusions  We provide a brief heuristic overview of our preclinical and clinical studies with the SSRI–antipsychotic combination and argue that the finding that it causes similar dynamic changes in laboratory and clinical domains, specifically in GABA-A β2/3 receptor and PKC, strongly supports the hypothesis that the GABA-A receptors and their regulatory systems are involved in the molecular mechanisms underlying the clinical effectiveness of SSRI augmentation. Content Type Journal ArticleCategory Original InvestigationPages 1-8DOI 10.1007/s00213-011-2530-yAuthors Lena Danovich, Molecular Neuropsychiatry Unit, Shaar Menashe Brain Behavior Laboratory, Shaar Menashe MHC and Technion-Faculty of Medicine, Mobile Post, 38814 Haifa, IsraelOrly Weinreb, Molecular Neur... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5322400 Tue, 11 Oct 2011 15:50:37 +0100 5322400 http://www.medworm.com/index.php?rid=5312350&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm311pk2130n6kt52%2F Conclusions  Selective breeding for alcohol locomotor stimulation also renders the mice more sensitive to the effects of alcohol, but not cocaine, on ICSS. Content Type Journal ArticleCategory Original InvestigationPages 1-12DOI 10.1007/s00213-011-2523-xAuthors Eric W. Fish, Department of Neurology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USAJ. Elliott Robinson, Department of Neurology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USAMichael C. Krouse, Department of Neurology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USAClyde W. Hodge, Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC, USACheryl Reed, Department of Behavioral Neuroscience, Portland Alcohol Researc... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5312350 Sat, 08 Oct 2011 05:52:47 +0100 5312350 http://www.medworm.com/index.php?rid=5302655&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm3038703918n32px%2F Conclusions  The smoker–nonsmoker difference in discounting is not confined to situations involving immediate rewards. Differences associated with potentially real versus hypothetical rewards and gender underscore the complexity of the smoking–delay discounting relationship. Content Type Journal ArticleCategory Original InvestigationPages 1-14DOI 10.1007/s00213-011-2521-zAuthors Suzanne H. Mitchell, Department of Behavioral Neuroscience, L470, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USAVanessa B. Wilson, Department of Behavioral Neuroscience, L470, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA Journal PsychopharmacologyOnline ISSN 1432-2072Print ISSN 0033-3158 (Sourc... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5302655 Fri, 07 Oct 2011 15:58:57 +0100 5302655 http://www.medworm.com/index.php?rid=5302656&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw320152616488064%2F Conclusions  In combination with previous findings that guanfacine improves the efficiency of working memory and other prefrontal functions, these results suggest that impulsive choice behaviors may also be ameliorated by strengthening prefrontal functions. Content Type Journal ArticleCategory Original InvestigationPages 1-13DOI 10.1007/s00213-011-2520-0Authors Soyoun Kim, Department of Neurobiology, Yale University School of Medicine, 333 Cedar Street, SHM B404, New Haven, CT 06510, USAIrina Bobeica, Department of Neurobiology, Yale University School of Medicine, 333 Cedar Street, SHM B404, New Haven, CT 06510, USANao J. Gamo, Department of Neurobiology, Yale University School of Medicine, 333 Cedar Street, SHM B404, New Haven, CT 06510, USAAmy F. T. Arnsten, Departm... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5302656 Fri, 07 Oct 2011 05:48:42 +0100 5302656 http://www.medworm.com/index.php?rid=5302657&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fugj735012542tm28%2F Conclusions  The data suggest that optimal glucose dosage may differ under different conditions of depleted blood glucose resources. In addition, glucoregulation was observed to be a moderating factor. However, further research is needed to develop a model of the moderating and mediating factors under which glucose facilitation is best achieved. Content Type Journal ArticleCategory Original InvestigationPages 1-13DOI 10.1007/s00213-011-2510-2Authors Lauren Owen, Centre for Human Psychopharmacology, Swinburne University of Technology, Hawthorne, 3122 VIC, AustraliaAndrew B. Scholey, Centre for Human Psychopharmacology, Swinburne University of Technology, Hawthorne, 3122 VIC, AustraliaYvonne Finnegan, Nutrition Sciences, GSK Nutritional Healthcare R&D, GlaxoSmithKline,... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5302657 Thu, 06 Oct 2011 15:42:33 +0100 5302657 http://www.medworm.com/index.php?rid=5302658&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw362m1745l6657x6%2F Conclusions  The present study confirms that heavy cannabis users develop tolerance to some of the impairing behavioral effects of cannabis. This tolerance was also evident in the underlying ERPs, suggesting that tolerance demonstrated on performance level is not (completely) due to behavioral compensation. Content Type Journal ArticleCategory Original InvestigationPages 1-10DOI 10.1007/s00213-011-2479-xAuthors Eef L. Theunissen, Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, P.O. Box 616, 6200MD Maastricht, The NetherlandsGerold F. Kauert, Department of Forensic Toxicology, Institute of Legal Medicine, Goethe University of Frankfurt, Frankfurt, GermanyStefan W. Toennes, Department of Forensic Toxi... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5302658 Thu, 06 Oct 2011 05:48:26 +0100 5302658 http://www.medworm.com/index.php?rid=5294981&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh5p8h0864742k463%2F Conclusions  These findings demonstrate nicotinic modulation of BI in subjects with both normal and disordered baseline performance. The effects on BI are consistent with cholinergic enhancement of signal detection processes and/or modulation of noradrenaline by nicotine. Content Type Journal ArticleCategory Original InvestigationPages 1-10DOI 10.1007/s00213-011-2476-0Authors Alexandra S. Potter, Clinical Neuroscience Research Unit, Department of Psychiatry, University of Vermont, 1 South Prospect Street, Burlington, VT 05401 USADavid J. Bucci, Department of Psychological and Brain Sciences, Dartmouth College, Hanover, NH, USAPaul A. Newhouse, Clinical Neuroscience Research Unit, Department of Psychiatry, University of Vermont, 1 South Prospect Street, Burlington, VT... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5294981 Tue, 04 Oct 2011 05:49:40 +0100 5294981 http://www.medworm.com/index.php?rid=5294980&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa160252253362157%2F Conclusions  Opiate administration and withdrawal increase galanin expression in the LC. Galanin opposes the actions of morphine which leads to opiate dependence and withdrawal, an effect that is mediated via GalR1. Content Type Journal ArticleCategory Original InvestigationPages 1-7DOI 10.1007/s00213-011-2515-xAuthors Fiona E. Holmes, Schools of Physiology and Pharmacology and Clinical Sciences, University of Bristol, Bristol, UKAthena Armenaki, Department of Pharmacology, Faculty of Medicine, University of Crete, Heraklion, Crete, GreeceTiina P. Iismaa, Neuroscience Program, Garvan Institute of Medical Research, Sydney, AustraliaEmily B. Einstein, Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USAJohn Shine, Neuroscience Program, Garvan... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5294980 Tue, 04 Oct 2011 05:49:40 +0100 5294980 http://www.medworm.com/index.php?rid=5283077&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa48568670p320180%2F Conclusions  Attenuation of the cocaine stimulus by VU0357017 depended upon M1 receptors, and full effects of xanomeline depended upon both M1 and M4 receptors. Therefore M1-selective agonists and mixed M1/M4 agonists may be promising leads for developing medications that block cocaine’s effects. Content Type Journal ArticleCategory Original InvestigationPages 1-13DOI 10.1007/s00213-011-2516-9Authors Morgane Thomsen, Alcohol and Drug Abuse Research Center, McLean Hospital/Harvard Medical School, Belmont, MA, USACraig W. Lindsley, Vanderbilt Program in Drug Discovery, Vanderbilt Specialized Chemistry Center (Molecular Libraries Probe Production Centers Network; MLPCN), Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USAP. Jeffrey Conn,... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5283077 Sat, 01 Oct 2011 06:44:20 +0100 5283077 http://www.medworm.com/index.php?rid=5283078&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F42r0q273j0500514%2F Conclusions  Opioid antagonism in opioid-dependent subjects leads to a smaller sweet taste reward, which, in turn, may be proportional to decreased opioid craving. These pilot results support the heuristic value of the STT as a potential marker of the XRNT treatment response and call for further inquiry into potential clinical applications of the test. Content Type Journal ArticleCategory Original InvestigationPages 1-6DOI 10.1007/s00213-011-2503-1Authors Daniel D. Langleben, Department of Psychiatry, University of Pennsylvania Perlman School of Medicine, Philadelphia, PA, USAElliot L. Busch, Department of Psychiatry, University of Pennsylvania Perlman School of Medicine, Philadelphia, PA, USACharles P. O’Brien, Department of Psychiatry, University of Pennsylvania ... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5283078 Fri, 30 Sep 2011 05:49:47 +0100 5283078 http://www.medworm.com/index.php?rid=5283079&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk374t7260h2l004h%2F Conclusions  Findings suggest that acute tolerance to impairment of motor coordination is insufficient to promote recovery of driving performance and that the persistence of alcohol-induced disinhibition might contribute to risky decisions to drive on the descending limb. Content Type Journal ArticleCategory Original InvestigationPages 1-10DOI 10.1007/s00213-011-2519-6Authors Jessica Weafer, Department of Psychology, University of Kentucky, Kastle Hall, Lexington, KY 40506-0044, USAMark T. Fillmore, Department of Psychology, University of Kentucky, Kastle Hall, Lexington, KY 40506-0044, USA Journal PsychopharmacologyOnline ISSN 1432-2072Print ISSN 0033-3158 (Source: Psychopharmacology) Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5283079 Fri, 30 Sep 2011 05:49:46 +0100 5283079 http://www.medworm.com/index.php?rid=5283080&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F243675q273k46n16%2F Conclusions  The reinforcement-attenuating and discriminative stimulus effects of nicotine delivered in an extract of a commercial smokeless tobacco product differed from those of nicotine alone. Extracts of tobacco products may be useful for evaluating the abuse liability of those products and understanding the role of non-nicotine constituents in tobacco addiction. Content Type Journal ArticleCategory Original InvestigationPages 1-12DOI 10.1007/s00213-011-2514-yAuthors Andrew C. Harris, Minneapolis Medical Research Foundation, 914 South 8th St,. S-3 Labs, 860, Minneapolis, MN 55404, USAIrina Stepanov, Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USAPaul R. Pentel, Minneapolis Medical Research Foundation, 914 South 8th St,. S-3 Labs, 860, Minneap... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5283080 Fri, 30 Sep 2011 05:49:44 +0100 5283080 http://www.medworm.com/index.php?rid=5283081&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu18718v07135w835%2F Conclusions  These results suggest that minocycline led to more rational decision-making strategies, possibly by increasing emotion regulation. Since minocycline is a well-known inhibitor of microglial activation, our findings may open a new optional pathway for treating mental states in which a component of rational decision making is impaired. Content Type Journal ArticleCategory Original InvestigationPages 1-7DOI 10.1007/s00213-011-2509-8Authors Motoki Watabe, Waseda Institute for Advanced Study, Waseda University, Building No.9. 1-6-1 Nishi-Waseda, Shinjuku, Tokyo 169-8050, JapanTakahiro A. Kato, Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi Higashi-ku, Fukuoka, 812-8582 JapanAkira Monji, Department of Neuro... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5283081 Thu, 29 Sep 2011 06:18:04 +0100 5283081 http://www.medworm.com/index.php?rid=5283082&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb4rgg05771h16917%2F Conclusions  For the first time, IT/AVT and OT/AVP were found to modulate in zebrafish, social behavior, unrelated to sex, and fear to predator response through at least two different receptors. Zebrafish is confirmed as a valid, reliable model to study deficit in social behavior characteristic of some psychiatric disorders. Content Type Journal ArticleCategory Original InvestigationPages 1-12DOI 10.1007/s00213-011-2482-2Authors Daniela Braida, Department of Pharmacology, Chemotherapy and Medical Toxicology, Università degli Studi di Milano, Milan, ItalyAndrea Donzelli, Department of Pharmacology, Chemotherapy and Medical Toxicology, Università degli Studi di Milano, Milan, ItalyRoberta Martucci, Department of Pharmacology, Chemotherapy and Medical Toxicology, Univ... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5283082 Thu, 29 Sep 2011 06:18:02 +0100 5283082 http://www.medworm.com/index.php?rid=5283083&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj5240v5811272v77%2F Conclusions  Histamine can function as a punisher in the choice between injections of cocaine and delay can decrease its effectiveness as a punisher. The effects of delaying punishment of drug self-administration can be conceptualized within the delay discounting framework. Content Type Journal ArticleCategory Original InvestigationPages 1-9DOI 10.1007/s00213-011-2501-3Authors William L. Woolverton, Division of Neurobiology and Behavior Research, Department of Psychiatry and Human Behavior, The University of Mississippi Medical Center, Jackson, MS 39216, USAKevin B. Freeman, Division of Neurobiology and Behavior Research, Department of Psychiatry and Human Behavior, The University of Mississippi Medical Center, Jackson, MS 39216, USAJoel Myerson, Department of Psycho... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5283083 Thu, 29 Sep 2011 06:18:00 +0100 5283083 http://www.medworm.com/index.php?rid=5271306&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe68234256140q353%2F Conclusions  Adolescent females with recent binge drinking showed ~8% thicker cortices in left frontal regions than demographically similar female non-drinkers, which was linked to worse visuospatial, inhibition, and attention performances. In contrast, adolescent binge-drinking males showed ~7% thinner cortices in these areas than non-drinking males. These cross-sectional data suggest either different gray matter risk factors for males as for females toward developing heavy drinking, or differential adverse sequelae. Content Type Journal ArticleCategory Original InvestigationPages 1-11DOI 10.1007/s00213-011-2500-4Authors Lindsay M. Squeglia, San Diego State University/University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, ... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5271306 Wed, 28 Sep 2011 05:51:05 +0100 5271306 http://www.medworm.com/index.php?rid=5271307&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm715772224302nj1%2F Conclusions  These data suggest that delay and probability discounting tap different dimensions, and delay discounting is more closely linked with substance use problem histories in pathological gamblers. Content Type Journal ArticleCategory Original InvestigationPages 1-9DOI 10.1007/s00213-011-2508-9Authors Leonardo F. Andrade, Calhoun Cardiology Center, MC-3944, University of Connecticut School of Medicine, 263 Farmington Avenue, Farmington, CT 06030-3944, USANancy M. Petry, Calhoun Cardiology Center, MC-3944, University of Connecticut School of Medicine, 263 Farmington Avenue, Farmington, CT 06030-3944, USA Journal PsychopharmacologyOnline ISSN 1432-2072Print ISSN 0033-3158 (Source: Psychopharmacology) Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5271307 Wed, 28 Sep 2011 05:51:04 +0100 5271307 http://www.medworm.com/index.php?rid=5271308&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F5255073r36465r8x%2F Conclusions  In general, MDMA did not affect driving performance nor did it change the impairing effects of sleep loss. It is concluded that MDMA cannot compensate for the impairing effects of sleep loss and that drivers who are under the influence of MDMA and sleep deprived are unfit to drive. Content Type Journal ArticleCategory Original InvestigationPages 1-10DOI 10.1007/s00213-011-2497-8Authors Wendy M. Bosker, Department Neuropsychology & Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The NetherlandsKim P. C. Kuypers, Department Neuropsychology & Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The NetherlandsSilke Conen, Department Neuropsychology & Psychopharmacology,... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5271308 Wed, 28 Sep 2011 05:51:02 +0100 5271308 http://www.medworm.com/index.php?rid=5271310&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F472pw1g2kr313343%2F Conclusions  Altogether, we propose that among group III mGlu receptors, mGlu4 receptor may be a promising target for the development of novel antipsychotic drugs. Content Type Journal ArticleCategory Original InvestigationPages 1-14DOI 10.1007/s00213-011-2502-2Authors Joanna M. Wierońska, Institute of Pharmacology, Polish Academy of Sciences, 31-343 Kraków, PolandKatarzyna Stachowicz, Institute of Pharmacology, Polish Academy of Sciences, 31-343 Kraków, PolandFrancine Acher, Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, UMR 8601 CNRS, Universite Paris Descartes, Paris, FranceTomasz Lech, Institute of Pharmacology, Polish Academy of Sciences, 31-343 Kraków, PolandAndrzej Pilc, Institute of Pharmacology, Polish Academy of Sciences, 31-343 K... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5271310 Wed, 28 Sep 2011 05:51:01 +0100 5271310 http://www.medworm.com/index.php?rid=5271309&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc24044t8453k3kr3%2F Conclusions  These findings challenge the notion of cue-induced craving as a primary trigger of disrupted cognition and drug-seeking behavior in addicted individuals, and raise the need to explore individual differences in compulsivity when addressing the links between craving and loss of control within research and clinical settings. Content Type Journal ArticleCategory Original InvestigationPages 1-8DOI 10.1007/s00213-011-2512-0Authors Antonio Verdejo-García, Melbourne Neuropsychiatry Center, University of Melbourne, Melbourne, VIC, AustraliaDan I. Lubman, Turning Point Alcohol and Drug Centre, Eastern Health and Monash University, 54-62 Gertrude Street, Fitzroy, VIC 3065, AustraliaAnne Schwerk, Melbourne Neuropsychiatry Center, University of Melbourne, Melbourne,... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5271309 Wed, 28 Sep 2011 05:51:01 +0100 5271309 http://www.medworm.com/index.php?rid=5271312&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F666239j5h562x4h3%2F Conclusion  These data demonstrate that caffeine administration sustained and reinstated nicotine-seeking behavior, possibly via its acquired discriminative-stimulus properties predictive of nicotine availability. These findings suggest that smokers who attempt to quit may benefit from stopping caffeine consumption. Content Type Journal ArticleCategory Original InvestigationPages 1-10DOI 10.1007/s00213-011-2505-zAuthors Xiu Liu, Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USACourtney Jernigan, Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA Journal PsychopharmacologyOnline ISSN 1432-2072Pr... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5271312 Tue, 27 Sep 2011 05:51:25 +0100 5271312 http://www.medworm.com/index.php?rid=5271311&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn08403410mmu8382%2F Conclusions  The most parsimonious interpretation of these effects is that CP55940 has some effects through corticosteroid-dependent actions and opposite effects by corticosteroid-independent actions. These two putative sites of actions affect stimulus gating opposite to their effects on response gating. Content Type Journal ArticleCategory Original InvestigationPages 1-11DOI 10.1007/s00213-011-2493-zAuthors Avdesh Avdesh, Centre for Clinical Research in Neuropsychiatry, Graylands Hospital, The University of Western Australia, Perth, Western Australia, AustraliaVincent Cornelisse, School of Pharmacology and Medicine, The University of Western Australia, Perth, Western Australia, AustraliaMathew Thomas Martin-Iverson, School of Pharmacology and Medicine, The Universit... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5271311 Tue, 27 Sep 2011 05:51:25 +0100 5271311 http://www.medworm.com/index.php?rid=5271313&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm00625m385j87r35%2F This study demonstrated that inhibition of CRF2-receptor-mediated serotonergic transmission is a mechanism shared by LTG and CBZ, two clinically related compounds, whereas LTG but not CBZ inhibits CRF1-receptor-mediated serotonergic transmission. Therefore, these mechanisms may contribute to the clinical actions of these agents. Content Type Journal ArticleCategory Original InvestigationPages 1-12DOI 10.1007/s00213-011-2506-yAuthors Shunske Tanahashi, Department of Psychiatry, Division of Neuroscience, Graduate School of Medicine, Brain Science and Animal Model Research Center (BSAM), Mie University, 2-174 Edobashi, Tsu, Mie 514-8507, JapanSatoshi Yamamura, Department of Psychiatry, Division of Neuroscience, Graduate School of Medicine, Brain Science and Animal Model Research Cent... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5271313 Tue, 27 Sep 2011 05:51:22 +0100 5271313 http://www.medworm.com/index.php?rid=5258400&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F2t2509628834h782%2F Conclusions  5-HT2 receptors and α1 and β NE receptors may act through independent mechanisms to modulate sensorimotor gating and locomotor activity. Content Type Journal ArticleCategory Original InvestigationPages 1-15DOI 10.1007/s00213-011-2490-2Authors Sarah K. Baisley, Department of Psychiatry, UW-Madison, Madison, WI, USAKatherine L. Fallace, Department of Psychiatry, UW-Madison, Madison, WI, USAAbha K. Rajbhandari, Department of Psychiatry, UW-Madison, Madison, WI, USAVaishali P. Bakshi, Department of Psychiatry, UW-Madison, Madison, WI, USA Journal PsychopharmacologyOnline ISSN 1432-2072Print ISSN 0033-3158 (Source: Psychopharmacology) Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5258400 Sat, 24 Sep 2011 15:45:36 +0100 5258400 http://www.medworm.com/index.php?rid=5258401&cid=s_33312_172_f&fid=33312&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F63592643413g0g65%2F Conclusion  It is likely that lithium has a suppressive effect on impulsive action independent of the anorexic effect. Lithium may suppress impulsive behavior and thereby decrease the risk of suicide. The present results could provide an explanation for the antisuicidal effects of lithium and suggest that lithium could be a beneficial treatment for impulsivity-related disorders. Content Type Journal ArticleCategory Original InvestigationPages 1-12DOI 10.1007/s00213-011-2496-9Authors Yu Ohmura, Department of Neuropharmacology, Graduate School of Medicine, Hokkaido University, N15 W7 Kita-ku, Sapporo, 060-8638 JapanIku Tsutsui-Kimura, Department of Neuropharmacology, Graduate School of Medicine, Hokkaido University, N15 W7 Kita-ku, Sapporo, 060-8638 JapanHaruko Kumamot... Psychopharmacology journals http://www.medworm.com/rss/comments.php?id=5258401 Fri, 23 Sep 2011 15:46:08 +0100 5258401