MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Radiotherapy and Oncology' source. Thu, 09 Feb 2012 03:37:52 +0100 http://www.medworm.com/index.php?rid=5670026&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814012000382%2Fabstract%3Frss%3Dyes (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5670026 Wed, 01 Feb 2012 05:00:00 +0100 5670026 http://www.medworm.com/index.php?rid=5669995&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814012000369%2Fabstract%3Frss%3Dyes (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5669995 Wed, 01 Feb 2012 05:00:00 +0100 5669995 http://www.medworm.com/index.php?rid=5669994&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814012000357%2Fabstract%3Frss%3Dyes (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5669994 Wed, 01 Feb 2012 05:00:00 +0100 5669994 http://www.medworm.com/index.php?rid=5670013&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011007444%2Fabstract%3Frss%3Dyes Conclusions: The predominant pattern of LR failure was marginal or out-of-field. LR failures may be preventable with improved radiotherapy target definition. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5670013 Mon, 30 Jan 2012 05:00:00 +0100 5670013 http://www.medworm.com/index.php?rid=5669996&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814012000047%2Fabstract%3Frss%3Dyes Improving the outcome of treatment of lung cancer remains a formidable and multidisciplinary task . Although distant metastases occur early and frequently in lung cancer it is important to realize that failure to achieve loco-regional control is an equally important reason for todays’ overall poor outcome in this disease . Therefore considerable recent research in the field of radiotherapy has been directed towards technological improvements in target identification by advanced imaging, conformal and motion corrected treatment planning methodologies, more precise as well as better monitored radiotherapy application, and bioimaging for individualized and adaptive treatment approaches . In parallel a large number of retrospective and prospective studies have addressed optimization of total... Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5669996 Mon, 30 Jan 2012 05:00:00 +0100 5669996 http://www.medworm.com/index.php?rid=5669999&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011007390%2Fabstract%3Frss%3Dyes Conclusion: A daily fixed dose of TMZ during WBI without adjuvant TMZ was well tolerated and significantly improved local control of BM compared with WBI alone. These findings require confirmation in a phase III trial (ClinicalTrials.gov number, NCT01015534). (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5669999 Wed, 18 Jan 2012 05:00:00 +0100 5669999 http://www.medworm.com/index.php?rid=5540012&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS016781401100733X%2Fabstract%3Frss%3Dyes (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5540012 Sun, 25 Dec 2011 20:44:56 +0100 5540012 http://www.medworm.com/index.php?rid=5539983&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011007316%2Fabstract%3Frss%3Dyes (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5539983 Sun, 25 Dec 2011 20:44:56 +0100 5539983 http://www.medworm.com/index.php?rid=5539982&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011007304%2Fabstract%3Frss%3Dyes (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5539982 Sun, 25 Dec 2011 20:44:56 +0100 5539982 http://www.medworm.com/index.php?rid=5670019&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011007067%2Fabstract%3Frss%3Dyes Conclusions: This new technique based on the Memocore™ lung stent used in connection with respiratory gated radiotherapy was demonstrated to be feasible in a porcine model. The study demonstrated lack of reproducibility in lung trajectories of inserted stents. The technique gave the best accuracy when applied to the exhale phase of respiration. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5670019 Fri, 23 Dec 2011 05:00:00 +0100 5670019 http://www.medworm.com/index.php?rid=5670017&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011007080%2Fabstract%3Frss%3Dyes Abstract: We studied the use of internal anatomical surrogates (carina and diaphragm) for the purpose of predicting the 3D position of lung tumours in 41 patients, in whom repeat 4DCT scans were available. Despite using two surrogates, significant prediction errors were observed, which varied depending on tumour position, baseline tumour motion and respiratory phase. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5670017 Fri, 23 Dec 2011 05:00:00 +0100 5670017 http://www.medworm.com/index.php?rid=5670016&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011007110%2Fabstract%3Frss%3Dyes Conclusions: The setup uncertainties at the two institutions are the same despite different fixation equipments. Hence margins cannot be reduced by changing fixating equipment. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5670016 Fri, 23 Dec 2011 05:00:00 +0100 5670016 http://www.medworm.com/index.php?rid=5670006&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011006050%2Fabstract%3Frss%3Dyes Abstract: A practical technique is presented to deliver hippocampus avoiding prophylactic cranial irradiation for lung cancer patients, using two lateral fields. For a prescribed dose of 12×2.5Gy, sparing of the hippocampi to 6.1Gy was achieved with a V95% of the brain of 81.7%. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5670006 Thu, 22 Dec 2011 05:00:00 +0100 5670006 http://www.medworm.com/index.php?rid=5539992&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011006104%2Fabstract%3Frss%3Dyes Conclusions: Higher radiation dose may contribute to the improvement of local control, especially in the field encompassed by IOERT. The addition of IOERT to surgery and adjuvant chemoradiation deserves further investigation in a randomized trial. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5539992 Mon, 19 Dec 2011 05:00:00 +0100 5539992 http://www.medworm.com/index.php?rid=5539984&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011007109%2Fabstract%3Frss%3Dyes In the past two decades a series of multi-institution clinical trials have done much to define the role of multi-modality treatment in the management of rectal adenocarcinoma. These trials have addressed a number of questions about sequencing of modalities, integration of radiation and chemotherapy, and radiation dose fractionation in the adjunctive management of patients undergoing extirpative surgery. Findings from single randomized trials include: (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5539984 Mon, 19 Dec 2011 05:00:00 +0100 5539984 http://www.medworm.com/index.php?rid=5444175&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011006748%2Fabstract%3Frss%3Dyes (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5444175 Fri, 25 Nov 2011 20:44:56 +0100 5444175 http://www.medworm.com/index.php?rid=5444143&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011006724%2Fabstract%3Frss%3Dyes (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5444143 Fri, 25 Nov 2011 20:44:56 +0100 5444143 http://www.medworm.com/index.php?rid=5444142&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011006712%2Fabstract%3Frss%3Dyes (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5444142 Fri, 25 Nov 2011 20:44:56 +0100 5444142 http://www.medworm.com/index.php?rid=5539998&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS016781401100627X%2Fabstract%3Frss%3Dyes Abstract: Background: Breast cancer sensitivity to large fraction size may be enhanced using hypofractionated concomitant boost radiotherapy (CBRT), thereby shortening overall treatment time. This ethics approved, prospective single cohort feasibility study was designed to evaluate the dosimetry and toxicity of CBRT using an intensity-modulated radiotherapy (IMRT) technique, compared with a standard sequential boost technique (SBT).Methods: Fifteen women (11 right-sided; 4 left-sided) received 42.4Gy to the whole breast and an additional 10.08Gy to the tumor bed in 16 daily fractions, using IMRT and standard dose constraints. Each patient was replanned with the SBT, using mixed photon–electrons. Clinical target volume (CTV), dose evaluation volume (DEV), and organs at risk (OAR) dose dis... Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5539998 Wed, 23 Nov 2011 05:00:00 +0100 5539998 http://www.medworm.com/index.php?rid=5539989&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS016781401100630X%2Fabstract%3Frss%3Dyes Conclusions: Planning results suggest that treatment with protons can improve the therapeutic tolerance for the irradiation of rectal cancer, particularly for patients scheduled for an irradiation with an intensified chemotherapy regimen and identified to be at high risk for acute therapy-related toxicity. However, clinical experiences and long-term observation are needed to assess tumor response and related toxicity rates. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5539989 Wed, 23 Nov 2011 05:00:00 +0100 5539989 http://www.medworm.com/index.php?rid=5670014&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011006086%2Fabstract%3Frss%3Dyes Abstract: Purpose/objective(s): IMRT allows dose escalation for large lung tumors, but respiratory motion may compromise delivery. A treatment plan that modulates fluence predominantly in the transversal direction and leaves the fluence identical in the direction of the breathing motion may reduce this problem.Materials/methods: Planning-CT-datasets of 20 patients with Stage I–IV non small cell lung cancer (NSCLC) formed the basis of this study. A total of two IMRT plans and one 3D plan were created for each patient. Prescription dose was 60Gy to the CTV and 70Gy to the GTV. For the 3D plans an energy of 18MV photons was used. IMRT plans were calculated for 6MV photons with 13 coplanar and with 17 noncoplanar beams. Robustness of the used method of anisotropic modulation toward breathing... Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5670014 Mon, 21 Nov 2011 05:00:00 +0100 5670014 http://www.medworm.com/index.php?rid=5670010&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011006281%2Fabstract%3Frss%3Dyes Conclusion: 18F-FDG PET/CT was specific in N0 staging for T1–2 NSCLC. The NPV was about 91% in clinical N0 patients, suggested that 18F-FDG PET/CT may help to accurately stage N0 patients and thus identify patients for SBRT. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5670010 Mon, 21 Nov 2011 05:00:00 +0100 5670010 http://www.medworm.com/index.php?rid=5670007&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011006220%2Fabstract%3Frss%3Dyes Abstract: Background: Individualised, isotoxic, accelerated radiotherapy (INDAR) allows the delivery of high biological radiation doses, but the long-term survival associated with this approach is unknown.Methods: Patients with stage III NSCLC in the Netherlands Cancer Registry/Limburg from January 1, 2002 to December 31, 2008 were included.Results: Patients (1002) with stage III NSCLC were diagnosed, of which 938 had T4 and/or N2–N3 disease. Patients treated with curative intent were staged with FDG-PET scans and a contrast-enhanced CT or an MRI of the brain. There were no shifts over time in the patient or tumour characteristics at diagnosis. The number of stage III NSCLC patients remained stable over time, but the proportion treated with palliative intent decreased from 47% in 2002 to... Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5670007 Mon, 21 Nov 2011 05:00:00 +0100 5670007 http://www.medworm.com/index.php?rid=5670001&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011006244%2Fabstract%3Frss%3Dyes Abstract: Purpose: To compare the positioning accuracy and stability of two distinct noninvasive immobilization devices, a dedicated (D-) and conventional (C-) mask, and to evaluate the applicability of a 6-degrees-of-freedom (6D) correction, especially to the C-mask, based on our initial experience with cranial stereotactic radiotherapy (SRT) using ExacTrac (ET)/Robotics integrated into the Novalis Tx platform.Materials and methods: The D- and C-masks were the BrainLAB frameless mask system and a general thermoplastic mask used for conventional radiotherapy such as whole brain irradiation, respectively. A total of 148 fractions in 71 patients and 125 fractions in 20 patients were analyzed for the D- and C-masks, respectively. For the C-mask, 3D correction was applied to the initial 10 pat... Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5670001 Mon, 21 Nov 2011 05:00:00 +0100 5670001 http://www.medworm.com/index.php?rid=5540002&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011006293%2Fabstract%3Frss%3Dyes Conclusion: Our study suggests there might be an association between the TGFβ1 29C>T polymorphism and CVD risk in long-term breast cancer survivors. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5540002 Mon, 21 Nov 2011 05:00:00 +0100 5540002 http://www.medworm.com/index.php?rid=5670009&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011006268%2Fabstract%3Frss%3Dyes Conclusions: We proposed a feature-based approach to evaluate radiation tumor response. Our study demonstrates that multimodality image-feature modeling provides better performance compared to existing metrics and holds promise for individualizing radiotherapy planning. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5670009 Fri, 18 Nov 2011 05:00:00 +0100 5670009 http://www.medworm.com/index.php?rid=5540001&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011006098%2Fabstract%3Frss%3Dyes Conclusions: The described method is superior to using tangential EPIs only and is recommended for position verification of breast cancer patients that are treated with a SIB technique if no Cone beam CT (CBCT) or fiducial markers can be used. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5540001 Fri, 18 Nov 2011 05:00:00 +0100 5540001 http://www.medworm.com/index.php?rid=5434184&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011006360%2Fabstract%3Frss%3Dyes Conclusions: Soy isoflavones augment destruction of A549 lung tumor nodules by radiation, and also mitigate vascular damage, inflammation and fibrosis caused by radiation injury to normal lung tissue. Soy could be used as a non-toxic complementary approach to improve RT in NSCLC. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5434184 Mon, 14 Nov 2011 05:00:00 +0100 5434184 http://www.medworm.com/index.php?rid=5434181&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011006372%2Fabstract%3Frss%3Dyes Conclusion: Postoperative RT with modern techniques is an effective method to obtain excellent local control and cure rates in mesothelioma patients submitted to EPP. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5434181 Mon, 14 Nov 2011 05:00:00 +0100 5434181 http://www.medworm.com/index.php?rid=5434167&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011006323%2Fabstract%3Frss%3Dyes Until quite recently, radiotherapy for lung cancer was mostly regarded as a palliative treatment, with only a small role in the curative setting. However, in the last decade, we have witnessed a wealth of clinical trials showing that radiotherapy is an important component in the treatment with curative intent, both for non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). In stage I NSCLC, many authors have shown that local tumour control rates of approximately 90% can be achieved by either stereotactic ablative radiation therapy (SABR) or high-dose radiotherapy delivered with modern techniques, with only few side effects . These results challenge the view that surgical resection should always be considered to be the first choice therapy for these patients and supports the ... Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5434167 Mon, 14 Nov 2011 05:00:00 +0100 5434167 http://www.medworm.com/index.php?rid=5670012&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011006037%2Fabstract%3Frss%3Dyes Conclusions: IFRT based on CT scan in our patients resulted in a low rate of INF (4.6%), all in the ipsilateral supraclavicular area; but another four supraclavicular nodal failures with simultaneously distant metastases were also observed. The modern imaging with higher diagnostic capabilities of lymph node especially for supraclavicular area should be incorporated in the assessment of LS-SCLC when IFRT is being contemplated. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5670012 Mon, 07 Nov 2011 05:00:00 +0100 5670012 http://www.medworm.com/index.php?rid=5434172&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS016781401100538X%2Fabstract%3Frss%3Dyes Conclusions: Reirradiation with SBRT is feasible although increased risk of toxicity was reported in centrally located tumours. Further research is warranted for more accurate selection of patients suitable for reirradiation with SBRT. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5434172 Mon, 07 Nov 2011 05:00:00 +0100 5434172 http://www.medworm.com/index.php?rid=5434170&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011005433%2Fabstract%3Frss%3Dyes Abstract: Introduction: As a finding of benign disease is uncommon in Dutch patients undergoing surgery after a clinical diagnosis of stage I NSCLC, patients are also accepted for stereotactic ablative radiotherapy (SABR) without pathology. We studied outcomes in patients who underwent SABR after either a pathological (n=209) or clinical diagnosis (N=382).Materials and methods: Five hundred and ninety-one patients with a single pulmonary lesion underwent SABR after either a pathological- or a clinical diagnosis of stage I NSCLC based on a 18FDG-PET positive lesion with CT features of malignancy. SABR was delivered to a total dose of 60Gy in 3, 5 or 8 fractions, and outcomes were compared between groups with and without pathological diagnosis.Results: Patients with pathology had significant... Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5434170 Mon, 07 Nov 2011 05:00:00 +0100 5434170 http://www.medworm.com/index.php?rid=5434186&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS016781401100658X%2Fabstract%3Frss%3Dyes (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5434186 Tue, 01 Nov 2011 04:00:00 +0100 5434186 http://www.medworm.com/index.php?rid=5434166&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011006566%2Fabstract%3Frss%3Dyes (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5434166 Tue, 01 Nov 2011 04:00:00 +0100 5434166 http://www.medworm.com/index.php?rid=5434165&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011006554%2Fabstract%3Frss%3Dyes (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5434165 Tue, 01 Nov 2011 04:00:00 +0100 5434165 http://www.medworm.com/index.php?rid=5391950&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011005640%2Fabstract%3Frss%3Dyes Conclusions: The standardized G2-assay can minimize inter-laboratory and intra-experimental variations and may have straightforward application in clinical practice for individualization of radiotherapy protocols. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5391950 Thu, 20 Oct 2011 04:00:00 +0100 5391950 http://www.medworm.com/index.php?rid=5391945&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011005639%2Fabstract%3Frss%3Dyes The understanding of biological contributions to radiation response and their underlying molecular basis has progressed remarkably in recent years. Importantly, the pursuit of a molecular understanding of radiation biology has led not only to an enormous gain in basic knowledge, but also stimulated the implementation of molecular aspects into treatment strategies in radiation oncology. Research areas with the strongest impact on developing new biology-driven treatment strategies in radiotherapy include: (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5391945 Thu, 20 Oct 2011 04:00:00 +0100 5391945 http://www.medworm.com/index.php?rid=5444154&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011005421%2Fabstract%3Frss%3Dyes Conclusions: Use of a systematic pain control program may improve compliance with CRT. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5444154 Mon, 17 Oct 2011 04:00:00 +0100 5444154 http://www.medworm.com/index.php?rid=5444153&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011005445%2Fabstract%3Frss%3Dyes Conclusions: A worse periodontal condition at dental screening and initial periodontal therapy to safeguard these patients to develop severe oral sequelae after radiotherapy were shown to be major risk factors of developing osteoradionecrosis. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5444153 Mon, 17 Oct 2011 04:00:00 +0100 5444153 http://www.medworm.com/index.php?rid=5391961&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011005627%2Fabstract%3Frss%3Dyes Conclusions: The effects of radiation-induced atherosclerosis could not be circumvented by these specific anti-inflammatory and anti-coagulant therapies. This suggests that more effective drug combinations may be required to overcome the radiation stimulus, or that other underlying mechanistic pathways are involved compared to age-related atherosclerosis. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5391961 Mon, 17 Oct 2011 04:00:00 +0100 5391961 http://www.medworm.com/index.php?rid=5669997&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011005184%2Fabstract%3Frss%3Dyes Abstract: The optimal management of brain metastases remains controversial. Both whole brain radiotherapy (WBRT) and local treatment [surgery (S) or radiosurgery (RS)] are the cornerstones of treatment. The role of systemic therapy is also being explored. Randomized controlled trials (RCT) have tried to assess the individual and combined effects of different therapeutic strategies.(1) RCT in oligometastatic patients: WBRT alone vs. local treatment+WBRT. Combined treatment may improve both overall survival and local control in patients with a single metastasis, but it also leads to a local control benefit in patients with two to four lesions.Exclusive local treatment vs. WBRT plus local treatment. The addition of WBRT to local treatment may result in improved local control, improved freedom... Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5669997 Thu, 13 Oct 2011 04:00:00 +0100 5669997 http://www.medworm.com/index.php?rid=5540003&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011005366%2Fabstract%3Frss%3Dyes Conclusions: A predictive 15-gene hypoxia classifier could identify patients associated with improved outcome after combining radiotherapy with hypoxic modification and underlines the relevance of such therapy. The impact of the classifier was limited to HPV-negative tumours. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5540003 Thu, 13 Oct 2011 04:00:00 +0100 5540003 http://www.medworm.com/index.php?rid=5539994&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS016781401100541X%2Fabstract%3Frss%3Dyes Conclusions: In the management of node negative T1–T2 anal cancer, LRC and CSS tend to be superior in patients treated by combined CRT, even though the difference was not significant. Randomized studies are warranted to assess definitively the role of combined treatment in early-stage anal carcinoma. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5539994 Thu, 13 Oct 2011 04:00:00 +0100 5539994 http://www.medworm.com/index.php?rid=5539996&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011005342%2Fabstract%3Frss%3Dyes Conclusions: Traditional 3DCRT plans provide inadequate nodal coverage. Prone IMRT technique resulted in optimal target coverage and reduced ipsilateral lung V20. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5539996 Wed, 12 Oct 2011 04:00:00 +0100 5539996 http://www.medworm.com/index.php?rid=5670024&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS016781401100510X%2Fabstract%3Frss%3Dyes We credit Fogliata et al. for reporting the treatment of CSI with VMAT technique. It is worth commenting that VMAT delivers highly conformal radiation in less overall time. The issue of junction matching can be well taken care of at the time of planning. However the volume of lung receiving 5Gy (V5) has not been reported by the above authors. Knowledge of the same is necessary before accepting a newer modality of radiation delivery. V5 of lung is an important criterion which predicts grade 3 or more treatment related pulmonary toxicity. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5670024 Mon, 10 Oct 2011 04:00:00 +0100 5670024 http://www.medworm.com/index.php?rid=5670023&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011005202%2Fabstract%3Frss%3Dyes In their recent paper, Corvo et al. propose a new concept for intensifying bone marrow dose prior to stem cell transplantation: helical tomotherapy in addition to total body irradiation (TBI) . In a previous study Einsele et al. applied the total marrow irradiation (9Gy) in patients with multiple myeloma . In their study toxicity was relatively high, but the recurrence rate was very low and the event free survival was long. Corvo et al. report no increase in acute side effects, but the incidence of long-term side effects could not be reliably assessed yet due to the relatively short follow-up. Conditioning prior to stem cell transplantation of leukaemia patients is a balancing act between dose escalation to achieve a better cure rate and dose de-escalation to get fewer side effects (so tha... Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5670023 Mon, 10 Oct 2011 04:00:00 +0100 5670023 http://www.medworm.com/index.php?rid=5444173&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS016781401100394X%2Fabstract%3Frss%3Dyes Abstract: Randomised controlled trials (RCTs) can be hampered by poor patient accrual and retention. Decision aids (DAs) containing simple, evidence-based information, may assist patients with decision-making regarding trial participation. The current DA was of use for 95% of participants. Further evaluation of the DA in a RCT is currently underway. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5444173 Mon, 10 Oct 2011 04:00:00 +0100 5444173 http://www.medworm.com/index.php?rid=5444160&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011005123%2Fabstract%3Frss%3Dyes Abstract: Background and purpose: Radiation pneumonitis is a significant toxicity following thoracic radiotherapy with no method to predict individual risk.Materials and methods: Sixty-five patients receiving thoracic radiation for lung or esophageal cancer were enrolled in a phase II study. Each patient received respiratory surveys and exhaled nitric oxide measurements before, on the last day of, and 30–60days after completing radiotherapy (RT). Pneumonitis toxicity was scored using the common terminology criteria for adverse events, version 4.0. The demographics, dosimetric factors, and nitric oxide ratio (NOR) of end RT/pre-RT were evaluated for correlation with symptomatic patients (Grade ⩾2).Results: Fifty patients completed the trial. The pneumonitis toxicity score was: Grade 3 f... Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5444160 Mon, 10 Oct 2011 04:00:00 +0100 5444160 http://www.medworm.com/index.php?rid=5444157&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011005305%2Fabstract%3Frss%3Dyes Conclusion: The prognosis of patients with ATC remains grim and our current results appear inferior to those reported previously by our institution. More accurate histologic diagnoses and patient selection in the present series compared to the prior one may be responsible in part. Better therapy is desperately needed for this aggressive disease. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5444157 Mon, 10 Oct 2011 04:00:00 +0100 5444157 http://www.medworm.com/index.php?rid=5434183&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011005135%2Fabstract%3Frss%3Dyes Conclusions: Automated 4D-CT propagation tools can significantly decrease the IGTV delineation time without significantly decreasing the inter- and intra-physician variability. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5434183 Mon, 10 Oct 2011 04:00:00 +0100 5434183 http://www.medworm.com/index.php?rid=5434180&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011005159%2Fabstract%3Frss%3Dyes Conclusions: This study suggests that PIT in mesothelioma reduces the incidence of procedure tract metastasis. Finally, chemotherapy does not seem to have an influence on the incidence of tract metastasis. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5434180 Mon, 10 Oct 2011 04:00:00 +0100 5434180 http://www.medworm.com/index.php?rid=5317945&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011005329%2Fabstract%3Frss%3Dyes Conclusions: Gated radiotherapy could potentially allow a reduction in PTV volumes from those delineated on all respiratory phases, maintaining acceptable target coverage. Smaller target volumes improve doses distribution in normal tissue especially in the liver and kidney, but also spinal cord and intestine. A significant correlation has been found between dose and volume reduction in the OARs and both GTV motion and PTV volume reduction. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5317945 Wed, 05 Oct 2011 04:00:00 +0100 5317945 http://www.medworm.com/index.php?rid=5317940&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011005408%2Fabstract%3Frss%3Dyes ‘Those who cannot remember the past are condemned to repeat it’: George Santayana, The Life of Reason, volume 1, 1905‘History is more or less bunk. It’s tradition. We dont want tradition. We want to live in the present’: Henry Ford, interview in the Chicago Tribune, May 25th 1916‘Prediction is difficult, especially about the future’: attributed to Neils Bohr (citing Storm P, Danish comedian and cartoonist) (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5317940 Tue, 04 Oct 2011 04:00:00 +0100 5317940 http://www.medworm.com/index.php?rid=5670018&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011004981%2Fabstract%3Frss%3Dyes Conclusions: Changes in breathing motion have been found that emphasize a need for continued position monitoring. RADPOS measurements can be used to monitor such variations as well as to measure surface dose without any disruption to the treatment schedule or discomfort to patients. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5670018 Mon, 03 Oct 2011 04:00:00 +0100 5670018 http://www.medworm.com/index.php?rid=5539995&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011005214%2Fabstract%3Frss%3Dyes Conclusions: ABAS produced satisfactory results for these clinical target volumes that are defined by more complex tissue interface geometry, thus streamlining and facilitating the radiotherapy workflow which is essential to face increasing demand and limited resources. STAPLE improved contouring outcome. Small target volumes not clearly defined are still to be delineated manually. Based on these results, ABAS has been clinically introduced for precontouring of CTVs/OARs. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5539995 Mon, 03 Oct 2011 04:00:00 +0100 5539995 http://www.medworm.com/index.php?rid=5444174&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011005093%2Fabstract%3Frss%3Dyes We write to draw readers’ attention to a little recognised form of bias that can influence conclusions which are drawn from the study of patient treatment response subgroups derived after the treatment results become known . We use some of our own data to illustrate the issue. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5444174 Mon, 03 Oct 2011 04:00:00 +0100 5444174 http://www.medworm.com/index.php?rid=5444158&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS016781401100507X%2Fabstract%3Frss%3Dyes Abstract: Purpose: To compare radiotherapy treatment plans for mid- and distal-esophageal cancer with primary involvement of the gastroesophageal (GE) junction using a novel IMRT & Arc technique (IMRT & Arc), helical tomotherapy (HT), and RapidArc (RA1 and RA2).Methods and materials: Eight patients treated on HT for locally advanced esophageal cancer with radical intent were re-planned for RA and IMRT&Arc. RA plans employed single and double arcs (RA1 and RA2, respectively), while IMRT&Arc plans had four fixed-gantry IMRT fields and a conformal arc. Dose-volume histogram statistics, dose uniformity, and dose homogeneity were analyzed to compare treatment plans.Results: RA2 plans showed significant improvement over RA1 plans in terms of OAR dose and PTV dose uniformity and homogeneity. HT p... Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5444158 Mon, 03 Oct 2011 04:00:00 +0100 5444158 http://www.medworm.com/index.php?rid=5444151&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011005007%2Fabstract%3Frss%3Dyes Conclusion: All treatment paradigms produced plans of excellent quality and dosimetric accuracy with IMRT providing best OAR sparing and VMAT being the most efficient treatment option in our comparison of treatment plans with high complexity. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5444151 Mon, 03 Oct 2011 04:00:00 +0100 5444151 http://www.medworm.com/index.php?rid=5317963&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011005354%2Fabstract%3Frss%3Dyes Conclusion: This phantom study demonstrates that Al2O3:C real-time dosimetry can identify applicator displacements ⩾5mm and interchanged guide tube errors during PDR and HDR brachytherapy. The study demonstrates the shortcoming of a constant error criterion and the advantage of a statistical error criterion. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5317963 Mon, 03 Oct 2011 04:00:00 +0100 5317963 http://www.medworm.com/index.php?rid=5317961&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011005330%2Fabstract%3Frss%3Dyes Conclusions: Agreement of COMPASS QA results with film based QA supports its clinical introduction for a phantom geometry. A standard MLC calibration check is sensitive to (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5317961 Mon, 03 Oct 2011 04:00:00 +0100 5317961 http://www.medworm.com/index.php?rid=5317959&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011005317%2Fabstract%3Frss%3Dyes Abstract: Background and purpose: The aim was to evaluate the impact of a spacer gel on the dose distribution, applying three-dimensional conformal (3D CRT) and intensity modulated radiotherapy (IMRT) planning techniques.Material and methods: The injection of a spacer gel (10ml SpaceOAR™) was performed between the prostate and rectum under transrectal ultrasound guidance in 18 patients with prostate cancer. 3D CRT and IMRT treatment plans were compared based on CT before and after injection (78Gy prescription dose).Results: In contrast to the PTV and bladder, significant advantages (p50% for both IMRT and 3D CRT. Significantly (p (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5317959 Mon, 03 Oct 2011 04:00:00 +0100 5317959 http://www.medworm.com/index.php?rid=5317957&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011005226%2Fabstract%3Frss%3Dyes Conclusions: Direct calibration of ICs versus radiochromic films provided correction factors equivalent to those obtained following the TG-148 formalism. This study showed that ICs calibrated for conventional linear accelerators can be used for the calibration of the static beam delivered by a HT unit taking into account the particular reference conditions. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5317957 Mon, 03 Oct 2011 04:00:00 +0100 5317957 http://www.medworm.com/index.php?rid=5317951&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011005287%2Fabstract%3Frss%3Dyes Conclusions: Angle optimization and SPECT-based modulation of importance factors allowed for functional avoidance of the lung while preserving target coverage. The technique could be also applied to implement PET-based modulation inside the target volume, leading to a safer dose escalation. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5317951 Mon, 03 Oct 2011 04:00:00 +0100 5317951 http://www.medworm.com/index.php?rid=5317949&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011005263%2Fabstract%3Frss%3Dyes Conclusion: The visibility of the anatomy in 4D VMAT-CBCT reconstruction for lung cancer patients has the potential of using 4D VMAT-CBCT as a tool for verifying relative positions of tumour for each respiratory phase. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5317949 Mon, 03 Oct 2011 04:00:00 +0100 5317949 http://www.medworm.com/index.php?rid=5317941&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011005378%2Fabstract%3Frss%3Dyes Abstract: Brachytherapy has consistently provided a very conformal radiation therapy modality. Over the last two decades this has been associated with significant improvements in imaging for brachytherapy applications (prostate, gynecology), resulting in many positive advances in treatment planning, application techniques and clinical outcome. This is emphasized by the increased use of brachytherapy in Europe with gynecology as continuous basis and prostate and breast as more recently growing fields. Image guidance enables exact knowledge of the applicator together with improved visualization of tumor and target volumes as well as of organs at risk providing the basis for very individualized 3D and 4D treatment planning.In this commentary the most important recent developments in prostate,... Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5317941 Mon, 03 Oct 2011 04:00:00 +0100 5317941 http://www.medworm.com/index.php?rid=5391983&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011005950%2Fabstract%3Frss%3Dyes (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5391983 Sat, 01 Oct 2011 04:00:00 +0100 5391983 http://www.medworm.com/index.php?rid=5391944&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011005937%2Fabstract%3Frss%3Dyes (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5391944 Sat, 01 Oct 2011 04:00:00 +0100 5391944 http://www.medworm.com/index.php?rid=5391943&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011006311%2Fabstract%3Frss%3Dyes (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5391943 Sat, 01 Oct 2011 04:00:00 +0100 5391943 http://www.medworm.com/index.php?rid=5317962&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011005238%2Fabstract%3Frss%3Dyes Abstract: Detectability and impact of potential treatment machine errors on IMRT treatments were evaluated. The ability of the gamma index to detect deliberately introduced errors was assessed and their clinical impact was assessed using Tumour Control Probability (TCP) and Normal Tissue Complication Probability. TCP was only marginally affected by 2mm errors in MLC position. Dose delivery errors had greater impact but were not detected as effectively using the gamma index. Acceptance criteria should include mean dose as well as gamma to help identify errors in the delivered dose. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5317962 Wed, 28 Sep 2011 04:00:00 +0100 5317962 http://www.medworm.com/index.php?rid=5317952&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011005299%2Fabstract%3Frss%3Dyes Conclusions: Both large brush DPBC and sharp brush DPBN techniques can be used to considerably boost the dose to the FDG avid regions. However, significantly higher boost levels can be obtained using sharp brush DPBN although sometimes at the cost of a less increased dose to the low SUV regions. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5317952 Wed, 28 Sep 2011 04:00:00 +0100 5317952 http://www.medworm.com/index.php?rid=5317942&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011005251%2Fabstract%3Frss%3Dyes Conclusions: MDE may not always be eradicated by the beam penumbra or existing PTV margins using either 3D conformal or stereotactic radiotherapy. Nonetheless, TCP modeling indicates an overall local control rate above 90% for the stereotactic technique, while a non-zero CTV margin is recommended for better local control of MDE when using the 3D conformal technique. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5317942 Wed, 28 Sep 2011 04:00:00 +0100 5317942 http://www.medworm.com/index.php?rid=5317958&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011005275%2Fabstract%3Frss%3Dyes Conclusion: Experimental small field ORdet measured with the diode detectors used in this study are reproducible to within ±1.25% (standard uncertainty), with the precision of any one set of measurements can be characterized with a CV between 0.10% and 0.15%. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5317958 Mon, 26 Sep 2011 04:00:00 +0100 5317958 http://www.medworm.com/index.php?rid=5317956&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS016781401100524X%2Fabstract%3Frss%3Dyes Abstract: Purpose: To compare the dosimetric accuracy of advanced dose calculation algorithms for flattened (FF) and unflattened (FFF) photon beams.Material and methods: We compared the enhanced collapsed cone (eCC) algorithm implemented in OncentraMasterplan and the XVMC (MC) code in Monaco. Test plans were created for 10MV FF and FFF beams. Single beam tests were delivered to radiochromic films positioned within a solid water phantom and evaluated with 1D γ-index analysis. Conformal plans were verified with ion chambers in an anthropomorphic thorax phantom. IMRT plans were applied to the Delta4 system and evaluated with γ-criteria of 3% and 3mm.Results: 1D γ-index evaluation revealed significantly lower (p (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5317956 Mon, 26 Sep 2011 04:00:00 +0100 5317956 http://www.medworm.com/index.php?rid=5670025&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011005111%2Fabstract%3Frss%3Dyes The authors thank Dr. Gagan Saini and coworkers for their astute comments on cranio-spinal irradiation (CSI) treatment using Volumetric Modulated Arc Therapy (VMAT). Indeed no data related to V5Gy for lungs were reported in our paper on CSI , this metric being a reported predictor for radiation induction pneumonitis. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5670025 Wed, 21 Sep 2011 04:00:00 +0100 5670025 http://www.medworm.com/index.php?rid=5434174&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011005160%2Fabstract%3Frss%3Dyes Conclusions: The CG/GG genotypes of HSPB1 rs2868371 were associated with lower risk of RIET, compared with the CC genotype in patients with NSCLC treated with radio(chemo)therapy. This finding should be validated in large multi-institutional prospective trials. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5434174 Wed, 21 Sep 2011 04:00:00 +0100 5434174 http://www.medworm.com/index.php?rid=5317953&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011005056%2Fabstract%3Frss%3Dyes Conclusions: Clinical treatment planning tools were extended to allow non-uniform prescription. For planning we introduced confidence level based probabilistic optimization with non-uniform target dose, while confidence levels of ΔVH points summarize the probability of proper target coverage. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5317953 Wed, 21 Sep 2011 04:00:00 +0100 5317953 http://www.medworm.com/index.php?rid=5670008&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011005196%2Fabstract%3Frss%3Dyes Conclusions: Post-chemotherapy consolidation chest RT for ES-SCLC patients on this trial was well tolerated and associated with symptomatic chest recurrences in only 5/32 treated patients. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5670008 Mon, 19 Sep 2011 04:00:00 +0100 5670008 http://www.medworm.com/index.php?rid=5434182&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011005172%2Fabstract%3Frss%3Dyes Conclusion: LA-V25, LV- and RV-V30 prove to be predictors of asymptomatic alteration of valve functionality. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5434182 Mon, 19 Sep 2011 04:00:00 +0100 5434182 http://www.medworm.com/index.php?rid=5317967&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011005019%2Fabstract%3Frss%3Dyes Abstract: Purpose: To evaluate the feasibility of supine breast magnetic resonance imaging (MR) for definition and localization of the surgical bed (SB) after breast conservative surgery. To assess the inter-observer variability of surgical bed delineation on computed tomography (CT) and supine MR.Materials and methods: Patients candidate for breast brachytherapy and no contra-indications for MR were eligible for this study. Patients were placed in supine position, with the ipsilateral arm above the head in an immobilization device. All patients underwent CT and MR in the same implant/treatment position. Four points were predefined for CT-MRI image fusion. The surgical cavity was drawn on CT then MRI, by three independent observers. Fusion and analysis of CT and MR images were performed us... Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5317967 Mon, 19 Sep 2011 04:00:00 +0100 5317967 http://www.medworm.com/index.php?rid=5317966&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011004932%2Fabstract%3Frss%3Dyes Conclusion: Image and laparoscopic guided interstitial PDR-BT using the GEC ESTRO target concept is applicable for locally advanced primary vaginal or recurrent endometrial and cervical cancer resulting in an excellent local control rate and limited morbidity. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5317966 Mon, 19 Sep 2011 04:00:00 +0100 5317966 http://www.medworm.com/index.php?rid=5317965&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011004828%2Fabstract%3Frss%3Dyes This study examines the dose distribution within the HR CTV and intermediate (IR) CTV in patients with cervical cancer treated with definitive EBRT +/− concomitant chemotherapy and MRI-based IGABT between patients with local recurrence (LR) and patients in continuous complete local remission (CCLR).Material and methods: From 1998 to 2010, 265 patients were treated with definitive EBRT +/− concomitant chemotherapy and IGABT. Twenty-four LRs were documented. For the statistical analysis all patients with LR were matched to patients in CCLR from our database according to the following criteria: FIGO stage, histology, lymph node status, tumour size and chemotherapy.DVH parameters (D50, D90, D98, D100) were reported for HR CTV and IR CTV. In order to report the minimum dose in the region wh... Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5317965 Mon, 19 Sep 2011 04:00:00 +0100 5317965 http://www.medworm.com/index.php?rid=5317964&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011004993%2Fabstract%3Frss%3Dyes Conclusions: The Single Fraction HDR protocol results in high disease control rate and low toxicity similar to our previous protocol using two HDR insertions, with significant savings in resources. While mature results with longer follow-up are awaited, a single 15Gy may be considered as a standard fractionation regimen in combination with EBRT for men with intermediate risk disease. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5317964 Mon, 19 Sep 2011 04:00:00 +0100 5317964 http://www.medworm.com/index.php?rid=5317960&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011005020%2Fabstract%3Frss%3Dyes Abstract: A large air-filled parallel-plate extrapolation chamber in a phantom of water-equivalent material is used as a primary standard measuring device for low-energy interstitial brachytherapy sources from which the unit of absorbed dose to water can be derived. The chamber is suitable for low-energy photons with energies up to 50keV. The method to determine the absorbed dose to water was newly developed based on radiation transport theory. It offers a clear analytical expression to determine Dw. A conversion factor C(xi,xi+1) has to be applied to the difference of ionization charges measured at two plate separations xi and xi+1.The details of the method are presented. The determination of Dw of an I-125 seed is demonstrated by the measurement of a ‘BEBIG Symmetra I25.S16’ – seed... Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5317960 Mon, 19 Sep 2011 04:00:00 +0100 5317960 http://www.medworm.com/index.php?rid=5317955&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011005032%2Fabstract%3Frss%3Dyes Conclusions: This work suggests that GNP radiosensitisation is driven by inhomogeneities in dose on the nanoscale, rather than changes in dose over the entire cell, which may contribute to the similar radiosensitisation observed in megavoltage and kilovoltage experiments. The short range of these inhomogeneities and the variation in enhancement in different cells suggests sub-cellular localisation is important in determining GNP radiosensitisation. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5317955 Mon, 19 Sep 2011 04:00:00 +0100 5317955 http://www.medworm.com/index.php?rid=5317954&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011005147%2Fabstract%3Frss%3Dyes Conclusions: Based on a few CTs, our method generates patient-specific SB PRVs which are both sensitive and specific. Compared to conventional approaches, the patient-specific PRVs are either similar or better in predicting for SB voxels, and at the same time they occupy a smaller or similar volume in the patient. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5317954 Mon, 19 Sep 2011 04:00:00 +0100 5317954 http://www.medworm.com/index.php?rid=5317950&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS016781401100497X%2Fabstract%3Frss%3Dyes Conclusions: Overall radiation-induced changes and volume loss were observed in the parotid and submandibular gland using MR. The observed differences indicated an increased water content such as found in oedema. The overall changes could be related to the mean dose, with a slightly greater impact in the high dose area. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5317950 Mon, 19 Sep 2011 04:00:00 +0100 5317950 http://www.medworm.com/index.php?rid=5317948&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011005068%2Fabstract%3Frss%3Dyes Conclusions: A clinical DECT scanner was able to extract Z and ρe of tissue substitutes. Our simulation tool replicates the experiments within a reasonable accuracy. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5317948 Mon, 19 Sep 2011 04:00:00 +0100 5317948 http://www.medworm.com/index.php?rid=5317947&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011005044%2Fabstract%3Frss%3Dyes Conclusion: The online adaptive replanning technique based on daily respiration-gated diagnostic-quality CT combined with gated delivery can effectively correct for inter- and intra-fraction variations during radiation therapy. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5317947 Mon, 19 Sep 2011 04:00:00 +0100 5317947 http://www.medworm.com/index.php?rid=5317946&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011004968%2Fabstract%3Frss%3Dyes Conclusions: A novel, efficient and effective method was developed to correct for MV scatter in CBCT scans acquired concurrent with rotational radiotherapy. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5317946 Mon, 19 Sep 2011 04:00:00 +0100 5317946 http://www.medworm.com/index.php?rid=5317944&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011004956%2Fabstract%3Frss%3Dyes Abstract: Background and purpose: To validate the clinical usefulness of motion-compensated (MC) cone-beam (CB) computed tomography (CT) for image-guided radiotherapy (IGRT) in comparison to four-dimensional (4D) CBCT and three-dimensional (3D) CBCT.Material and methods: Forty-eight stereotactic body radiation therapy (SBRT) patients were selected. Each patient had 5–12 long CB acquisitions (4min) and 1–7 short CB acquisitions (1min), with a total of 349 and 150 acquisitions, respectively. 3D, 4D and MC CBCT images of every acquisition were reconstructed. Image quality, tumor positioning accuracy and tumor motion amplitude were quantified.Results: The mean image quality of long short acquisitions, measured using the correlation ratio with the planning CT, was 74%/70%, 67%/47% and 79%/7... Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5317944 Mon, 19 Sep 2011 04:00:00 +0100 5317944 http://www.medworm.com/index.php?rid=5540008&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011004464%2Fabstract%3Frss%3Dyes Conclusions: The quality aspects found through focus group discussions provided useful insight into how patients experience radiation care. Furthermore, concept mapping made these results more solid. To evaluate the quality of radiation care from the patient’s perspective, these quality aspects will be guiding in the development of a CQI Radiation Care. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5540008 Mon, 12 Sep 2011 04:00:00 +0100 5540008 http://www.medworm.com/index.php?rid=5539999&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011003987%2Fabstract%3Frss%3Dyes Conclusions: Accelerated PDR-brachytherapy following breast conserving surgery (BCS) for local IBTR results in local tumour control comparable to mastectomy. Morbidity is moderate; the cosmetic outcome is good and hardly any impairment on QoL is observed. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5539999 Mon, 12 Sep 2011 04:00:00 +0100 5539999 http://www.medworm.com/index.php?rid=5539997&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011004944%2Fabstract%3Frss%3Dyes Conclusion: Preoperative concurrent administration of RT and CT is an effective regimen. Long-term toxicity is moderate. This association deserves further evaluations in prospective trials. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5539997 Mon, 12 Sep 2011 04:00:00 +0100 5539997 http://www.medworm.com/index.php?rid=5444159&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011003938%2Fabstract%3Frss%3Dyes Abstract: Purpose: To compare the effectiveness of tomotherapy and three-dimensional (3D) conformal radiotherapy to spare normal critical structures (spinal cord, lungs, and ventricles) from excessive radiation in patients with distal esophageal cancers.Materials and methods: A retrospective dosimetric study of nine patients who had advanced gastro-esophageal (GE) junction cancer (7) or thoracic esophageal cancer (2) extending into the distal esophagus. Two plans were created for each of the patients. A three-dimensional plan was constructed with either three (anteroposterior, right posterior oblique, and left posterior oblique) or four (right anterior oblique, left anterior oblique, right posterior oblique, and left posterior oblique) fields. The second plan was for tomotherapy. Doses wer... Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5444159 Mon, 12 Sep 2011 04:00:00 +0100 5444159 http://www.medworm.com/index.php?rid=5434178&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS016781401100483X%2Fabstract%3Frss%3Dyes Abstract: Purpose: To compare the dosimetric performance of three different treatment techniques – conformal radiotherapy (CRT), double arcs volumetric modulated arc therapy (RapidArc, RA) and Hybrid-RapidArc (H-RA) for locally-advanced non-small cell lung cancer (NSCLC).Material and methods: CRT, RA and H-RA plans were optimized for 24 stage III NSCLC patients. The target prescription dose was 60Gy. CRT consisted of 5–7 coplanar fields, while RA comprised of two 204o arcs. H-RA referred to two 204o arcs plus 2 static fields, which accounted for approximately half of the total dose. The plans were optimized to fulfill the departmental plan acceptance criteria.Results: RA and H-RA yielded a 20% better conformity compared with CRT. Lung volume receiving >20Gy (V20) and mean lung dose (ML... Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5434178 Mon, 12 Sep 2011 04:00:00 +0100 5434178 http://www.medworm.com/index.php?rid=5539987&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011004786%2Fabstract%3Frss%3Dyes Abstract: Purpose: The aim of this study was to measure and improve the quality of target volume delineation by means of national consensus on target volume definition in early-stage rectal cancer.Methods and materials: The CTV’s for eight patients were delineated by 11 radiation oncologists in 10 institutes according to local guidelines (phase 1). After observer variation analysis a workshop was organized to establish delineation guidelines and a digital atlas, with which the same observers re-delineated the dataset (phase 2). Variation in volume, most caudal and cranial slice and local surface distance variation were analyzed.Results: The average delineated CTV volume decreased from 620 to 460cc (p (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5539987 Wed, 07 Sep 2011 04:00:00 +0100 5539987 http://www.medworm.com/index.php?rid=5539985&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011004087%2Fabstract%3Frss%3Dyes Conclusions: The design of preoperative concurrent boost IMRT with oral capecitabine could achieve high rate of ypCR with an acceptable toxicity profile. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5539985 Wed, 07 Sep 2011 04:00:00 +0100 5539985 http://www.medworm.com/index.php?rid=5444165&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011004440%2Fabstract%3Frss%3Dyes Conclusion: Patient self reporting of bowel motion, fibre, fluid intake was achievable but consistency of rectal filling was not improved. Improved understanding of the aetiology and management of rectal gas is indicated. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5444165 Wed, 07 Sep 2011 04:00:00 +0100 5444165 http://www.medworm.com/index.php?rid=5391955&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011004804%2Fabstract%3Frss%3Dyes Conclusions: Amuvatinib is a promising agent that may be used to decrease tumor cell resistance. Our work suggests that this is associated with decreased RAD51 expression and function and supports the further study of amuvatinib in combination with chemotherapy and radiotherapy. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5391955 Wed, 07 Sep 2011 04:00:00 +0100 5391955 http://www.medworm.com/index.php?rid=5317943&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011004798%2Fabstract%3Frss%3Dyes Conclusions: CBCT density changes in healthy lung tissue during radiotherapy correlate with the locally delivered dose and can be detected relatively early during the treatment. If these density changes are correlated to subsequent clinical toxicity this assay could form the basis for biological adaptive radiotherapy. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5317943 Wed, 07 Sep 2011 04:00:00 +0100 5317943 http://www.medworm.com/index.php?rid=5670003&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011004063%2Fabstract%3Frss%3Dyes Conclusions: The majority of oncologists who treat children believe discussing late effects with parents is important. However, there is mixed opinion on which late effects should be discussed and whether parents should be involved in deciding which treatments should be pursued. Research into perceived barriers to shared decision making and effective methods of improving the informed consent process in paediatric malignancies is needed. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5670003 Fri, 02 Sep 2011 04:00:00 +0100 5670003 http://www.medworm.com/index.php?rid=5444171&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011004002%2Fabstract%3Frss%3Dyes Abstract: Background: It is widely believed that younger prostate cancer patients are at greater risk of recurrence following radiotherapy (RT).Methods: From 1992 to 2007, 2168 (395 age ⩽60) men received conformal RT alone for prostate cancer at our institution (median dose=76Gy, range: 72–80). Multivariable analysis (MVA) was used to identify significant predictors for BF and PCSM. Cumulative incidence was estimated using the competing risk method (Fine and Gray) for BF (Phoenix definition) and PCSM to account for the competing risk of death.Results: With a median follow-up of 72.2months (range: 24.0–205.1), 8-year BF was 27.1% for age ⩽60 vs. 23.7% for age >60 (p=0.29). Eight-year PCSM was 3.0% for age ⩽60 vs. 2.0% for age >60 (p=0.52). MVA for BF identified initial PSA [adjust... Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5444171 Fri, 02 Sep 2011 04:00:00 +0100 5444171 http://www.medworm.com/index.php?rid=5444168&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011004452%2Fabstract%3Frss%3Dyes Conclusions: Catheter displacement can occur in the 1–3h between the planning CT scan and treatment. It is recommended that departments performing HDR prostate brachytherapy verify catheter positions immediately prior to treatment delivery. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5444168 Fri, 02 Sep 2011 04:00:00 +0100 5444168 http://www.medworm.com/index.php?rid=5434177&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011004580%2Fabstract%3Frss%3Dyes Abstract: Background: The maximum standardized uptake value (SUVmax) of FDG-PET may predict local recurrence for localized non-small-cell lung cancer (NSCLC) after stereotactic body radiotherapy (SBRT).Methods: Among 195 localized NSCLCs that were treated with total doses of either 40Gy or 50Gy in 5 SBRT fractions, we reviewed those patients who underwent pre-treatment FDG-PET using a single scanner for staging. Local control rates (LCRs) were obtained by the Kaplan–Meier method and a log-rank test. Prognostic significance was assessed by univariate and multivariate analyses.Results: A total of 95 patients with 97 lesions were eligible. Median follow-up was 16.0months (range: 6.0–46.3months). Local recurrences occurred in 9 lesions. By multivariate analysis, only the SUVmax of a primar... Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5434177 Fri, 02 Sep 2011 04:00:00 +0100 5434177 http://www.medworm.com/index.php?rid=5670020&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011003999%2Fabstract%3Frss%3Dyes Conclusion: Curatively intended radiotherapy alone can be offered to esophageal cancer patients, even when surgery and/or chemotherapy are not feasible. However, we observed severe toxicity in a substantial part of the patients. Given the relatively high rate of severe complications and the uncertainties regarding dose escalation, the addition of brachytherapy, with consequently high surface doses, should be limited to well-selected patients. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5670020 Thu, 01 Sep 2011 04:00:00 +0100 5670020 http://www.medworm.com/index.php?rid=5670015&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011004099%2Fabstract%3Frss%3Dyes Conclusions: We have demonstrated that real-time organ motion monitoring using image based markerless registration is feasible. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5670015 Thu, 01 Sep 2011 04:00:00 +0100 5670015 http://www.medworm.com/index.php?rid=5670011&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011004014%2Fabstract%3Frss%3Dyes Conclusions: FDG-PET images can be analysed during thoracic RT, given either alone or with chemotherapy, without disturbing radiation-induced artefacts. An average 50% decrease in SUVmax was observed around 40–45Gy (i.e., during week 5 of RT). The three delineation methods yielded consistent volume measurements before RT and during the first week of RT, while manual delineation appeared to be more reliable later on during RT. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5670011 Thu, 01 Sep 2011 04:00:00 +0100 5670011 http://www.medworm.com/index.php?rid=5540004&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011004427%2Fabstract%3Frss%3Dyes Abstract: Purpose: Trans-abdominal ultrasonography (US) is capable of determining size, shape, thickness, and diameter of uterus, cervix and disease at cervix or parametria. To assess the potential value of US for image-guided cervical cancer brachytherapy, we compared US-findings relevant for brachytherapy to the corresponding findings obtained from MR imaging.Materials and methods: Twenty patients with biopsy proven cervical cancer undergoing definitive radiotherapy with/without concomitant Cisplatin chemotherapy and suitable for brachytherapy were invited to participate in this study. US and MR were performed in a similar reproducible patient positioning after intracavitary application. US mid-sagittal and axial image at the level of external cervical os was acquired. Reference points D... Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5540004 Thu, 01 Sep 2011 04:00:00 +0100 5540004 http://www.medworm.com/index.php?rid=5539991&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011004476%2Fabstract%3Frss%3Dyes Conclusions: The repeated cycles of PRRT did not cause a clinically significant increase of the toxicity of PRRT. The changes in kidney and blood morphology parameters were transient. The repeated cycles of PRRT enabled stabilization of the disease. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5539991 Thu, 01 Sep 2011 04:00:00 +0100 5539991 http://www.medworm.com/index.php?rid=5444147&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011004038%2Fabstract%3Frss%3Dyes Conclusions: GTVp-CT was significantly larger when compared to GTVp-PET. No such change was observed for the lymph nodes. 18F-FDG-PET modified treatment management in three patients, including two for which no curative radiotherapy was attempted. Larger multicenter studies are needed to ascertain whether combined 18F-FDG-PET/CT in target delineation can influence the main clinical outcomes. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5444147 Thu, 01 Sep 2011 04:00:00 +0100 5444147 http://www.medworm.com/index.php?rid=5391960&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS016781401100418X%2Fabstract%3Frss%3Dyes Conclusion: Increased transdifferentiation and remodeling of acinar structures was associated with decrease of viable acinar structures. The role of Wnt and TGF signaling may provide a potential therapeutic approach to prevent radiation-induced damage to salivary glands during radiotherapy for head and neck cancer. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5391960 Thu, 01 Sep 2011 04:00:00 +0100 5391960 http://www.medworm.com/index.php?rid=5317968&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011005585%2Fabstract%3Frss%3Dyes (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5317968 Thu, 01 Sep 2011 04:00:00 +0100 5317968 http://www.medworm.com/index.php?rid=5317939&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011005561%2Fabstract%3Frss%3Dyes (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5317939 Thu, 01 Sep 2011 04:00:00 +0100 5317939 http://www.medworm.com/index.php?rid=5317938&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS016781401100555X%2Fabstract%3Frss%3Dyes (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5317938 Thu, 01 Sep 2011 04:00:00 +0100 5317938 http://www.medworm.com/index.php?rid=5670000&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011003963%2Fabstract%3Frss%3Dyes Conclusions: Reirradiation of BM with SRS resulted feasible and effective. A correct patient selection and an accurate evaluation of the cumulative irradiation dose were suggested. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5670000 Wed, 31 Aug 2011 04:00:00 +0100 5670000 http://www.medworm.com/index.php?rid=5670021&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011004051%2Fabstract%3Frss%3Dyes Conclusion: Substantial residual setup errors would occur for treatment fractions without IG even if the most frequent less-than-daily IG strategy was to be used, which could lead to significant daily dose variations for the target volume and adjacent normal tissues. Daily image guidance is recommended throughout the course of treatment in conformal radiotherapy for esophageal cancer. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5670021 Mon, 29 Aug 2011 04:00:00 +0100 5670021 http://www.medworm.com/index.php?rid=5540007&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011004191%2Fabstract%3Frss%3Dyes Conclusions: The ABC model provides insight into the financial consequences of evolving technology and practice. Such data are a mandatory first step in our strive to prove RT cost-effectiveness and thus support optimal reimbursement and provision of radiotherapy departments. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5540007 Mon, 29 Aug 2011 04:00:00 +0100 5540007 http://www.medworm.com/index.php?rid=5444164&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011003975%2Fabstract%3Frss%3Dyes Conclusion: ERB application significantly reduces Awall and to a lesser degree Rwall doses in high-dose post-prostatectomy IMRT. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5444164 Mon, 29 Aug 2011 04:00:00 +0100 5444164 http://www.medworm.com/index.php?rid=5444162&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011003951%2Fabstract%3Frss%3Dyes Abstract: Background and purpose: To report the long-term biochemical control of a non-randomized trial comparing standard (STD) and hyper-fractionated (HFX) radiation schedules for prostate cancer treatment.Materials and methods: Between 1993 and 2003, 370 patients entered the study; 330/370 (STD: 179; HFX: 151) were evaluable for current analysis. Median doses were 79.2Gy and 74Gy for HFX (1.2Gy/fr, two daily fractions) and STD (2Gy/fr), respectively; median follow-up was 7.5yr. The two regimens were compared in terms of biochemical relapse-free survival (according to ASTRO definition, bRFS) by univariate (log-rank test) and multivariate analyses (Cox regression hazard model). Based on published relationships between EQD2 and 5-yr biochemical control, α/β values for each subgroup could... Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5444162 Mon, 29 Aug 2011 04:00:00 +0100 5444162 http://www.medworm.com/index.php?rid=5444148&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011004075%2Fabstract%3Frss%3Dyes Conclusion: Combined FMISO-PET imaging and IMRT planning permit delivery of higher doses to hypoxic regions, increasing the predicted TCP (mean 17%) without increasing expected complications. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5444148 Mon, 29 Aug 2011 04:00:00 +0100 5444148 http://www.medworm.com/index.php?rid=5670005&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011003793%2Fabstract%3Frss%3Dyes Conclusions: fSRT is an effective treatment modality for uveal melanoma with a good local control. With that, fSRT is a serious eye sparing treatment modality. However, our FU is relatively short. Also, the number of secondary enucleations is substantial, mainly caused by NVG. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5670005 Wed, 24 Aug 2011 04:00:00 +0100 5670005 http://www.medworm.com/index.php?rid=5444167&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011003811%2Fabstract%3Frss%3Dyes Conclusion: HyRT to a dose of 66Gy in 22 fractions as a single treatment modality is convenient for patients and for the health care system and appears to provide similar results to other treatment choices. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5444167 Wed, 24 Aug 2011 04:00:00 +0100 5444167 http://www.medworm.com/index.php?rid=5444166&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011003914%2Fabstract%3Frss%3Dyes Conclusions: Automatic contractions from the outer surface provide quicker, more reproducible and reasonably accurate substitutes for BW_m. The widespread use of automatic contractions to create a bladder wall volume would assist in the consistent application of IMRT dose constraints and the interpretation of reported dose. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5444166 Wed, 24 Aug 2011 04:00:00 +0100 5444166 http://www.medworm.com/index.php?rid=5444163&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011003902%2Fabstract%3Frss%3Dyes Abstract: Purpose: Assessing predictors of acute bowel toxicity after whole-pelvis irradiation (WPRT) Image-guided Tomotherapy with simultaneous integrated boost on prostate/prostate bed.Methods and materials: In the period March 2005–April 2009, 178 patients were treated with radical or adjuvant/salvage intent with WPRT Tomotherapy. Median dose to the pelvic nodes was 51.8Gy/28 fractions while concomitantly delivering 65.5–74.2Gy to prostate/prostatic bed. The impact of many anatomical and clinical parameters on ⩾Grade 2 acute bowel toxicity was investigated by logistic analyses.Results: Only 15/178 patients (8.4%) experienced Grade 2 toxicity (none Grade 3). Main predictors at univariate analysis were nodal CTV (CTVN⩾380cc; OR: 3.7, p=0.017), treatment duration ( (Source: Radioth... Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5444163 Wed, 24 Aug 2011 04:00:00 +0100 5444163 http://www.medworm.com/index.php?rid=5434179&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011003926%2Fabstract%3Frss%3Dyes This study evaluated adjuvant helical tomotherapy after extrapleural pneumonectomy±neo-adjuvant chemotherapy in 24 patients with malignant pleural mesothelioma. Toxicity was judged acceptable despite 2 cases (8%) of suspected grade 5 pneumonitis. With a mean follow-up of 7months, 5 patients had distant and 2 local and distant failure. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5434179 Wed, 24 Aug 2011 04:00:00 +0100 5434179 http://www.medworm.com/index.php?rid=5391966&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS016781401100377X%2Fabstract%3Frss%3Dyes Conclusion: TIGAR abrogation provides a novel adjunctive therapeutic strategy against glial tumors by increasing radiation-induced cell impairment, thus allowing the use of lower radiotherapeutic doses. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5391966 Wed, 24 Aug 2011 04:00:00 +0100 5391966 http://www.medworm.com/index.php?rid=5670004&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011003781%2Fabstract%3Frss%3Dyes Conclusions: The more comfortable supine position is recommended for craniospinal irradiation in adult patients. Whole-body thermoplastic mask immobilization provides excellent repositioning accuracy. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5670004 Mon, 22 Aug 2011 04:00:00 +0100 5670004 http://www.medworm.com/index.php?rid=5391954&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011003768%2Fabstract%3Frss%3Dyes Conclusion: Nuclear accumulation of Survivin and interaction with components of the DNA-double-strand break (DSB) repair machinery indicates Survivin to regulate DSB damage repair that leads to a significant improvement of survival of LN229 glioblastoma cells. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5391954 Fri, 19 Aug 2011 04:00:00 +0100 5391954 http://www.medworm.com/index.php?rid=5187196&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011003835%2Fabstract%3Frss%3Dyes Conclusions: Patients received standard adjuvant chemotherapy plus radiation therapy was more effective than chemotherapy alone in women with triple-negative early-stage breast cancer after mastectomy. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5187196 Wed, 17 Aug 2011 23:00:00 +0100 5187196 http://www.medworm.com/index.php?rid=5391979&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011003756%2Fabstract%3Frss%3Dyes Conclusion: Information on both the extent of hypoxia and the level of interstitial hypertension in A-07 tumors can be derived from a single DCE-MRI series by using gadomelitol as contrast agent. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5391979 Tue, 16 Aug 2011 04:00:00 +0100 5391979 http://www.medworm.com/index.php?rid=5391952&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011003859%2Fabstract%3Frss%3Dyes Conclusions: Constitutive γ-H2AX and 53BP1 staining reveals a subset of patients with triple negative breast tumors that have a significantly poorer prognosis. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5391952 Tue, 16 Aug 2011 04:00:00 +0100 5391952 http://www.medworm.com/index.php?rid=5134725&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011003823%2Fabstract%3Frss%3Dyes Conclusion: The very intense RT-CT schedule was more efficient on disease control, but was also more toxic than accelerated RT alone, pointing out that there was no clear improvement of the therapeutic index. This study shows the limits of dose-intensification, with regard to concomitant RT-CT. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5134725 Tue, 09 Aug 2011 23:00:00 +0100 5134725 http://www.medworm.com/index.php?rid=5134738&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011003860%2Fabstract%3Frss%3Dyes Conclusion: We have developed a method to acquire MV-scatter-free kV CBCT images concomitant with the delivery of RapidArc treatment. Engineering development is necessary to improve the process, e.g. by synchronization of the MV and kV beams. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5134738 Sun, 07 Aug 2011 23:00:00 +0100 5134738 http://www.medworm.com/index.php?rid=5134737&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011003744%2Fabstract%3Frss%3Dyes Abstract: Purpose: Micromilieu-dependent quantification of γH2AX after irradiation in vivo and correlation with local tumour control.Materials and methods: Local tumour control was evaluated after irradiation of FaDu and SKX xenografts with ambient single doses. γH2AX foci were quantified in perfused and unperfused regions after different irradiation doses and at different time points.Results: The TCD50 of FaDu was 2-times higher compared to SKX (28.0Gy [95% C.I. 24.6; 31.3Gy] for FaDu; 14.9Gy [10.9; 18.9] for SKX, p (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5134737 Sun, 07 Aug 2011 23:00:00 +0100 5134737 http://www.medworm.com/index.php?rid=5134733&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011003884%2Fabstract%3Frss%3Dyes Abstract: Background: To analyse the overall clinical outcome and benefits by applying protocol based image guided adaptive brachytherapy combined with 3D conformal external beam radiotherapy (EBRT)±chemotherapy (ChT).Methods: Treatment schedule was EBRT with 45–50.4Gy±concomitant cisplatin chemotherapy plus 4×7Gy High Dose Rate (HDR) brachytherapy. Patients were treated in the “protocol period” (2001–2008) with the prospective application of the High Risk CTV concept (D90) and dose volume constraints for organs at risk including biological modelling. Dose volume adaptation was performed with the aim of dose escalation in large tumours (prescribed D90>85Gy), often with inserting additional interstitial needles. Dose volume constraints (D2cc) were 70–75Gy for rectum and sigmoid... Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5134733 Sun, 07 Aug 2011 23:00:00 +0100 5134733 http://www.medworm.com/index.php?rid=5134731&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS016781401100380X%2Fabstract%3Frss%3Dyes Abstract: Background and purpose: The EORTC 22881-10882 trial showed that for patients treated with breast conserving therapy (BCT), a 16Gy boost dose significantly improved local control, but increased the risk of breast fibrosis. A model to estimate the risk of ipsilateral breast relapse (IBR) already exists, but now a model has been developed which takes boost treatment into account and is based on centrally reviewed pathology.Materials and methods: A Cox model was developed based on central pathology review data and clinical data of 1603 patients from the EORTC 22881-10882 trial with a median follow-up of 11.5years. From a predefined set of variables, predictors with a maximal effect on 10-year IBR rate >4% were retained in the model. Bootstrap re-sampling was used to assess model cali... Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5134731 Sun, 07 Aug 2011 23:00:00 +0100 5134731 http://www.medworm.com/index.php?rid=5134726&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011003847%2Fabstract%3Frss%3Dyes Conclusion: Gefitinib was well-tolerated, but did not improve efficacy compared with placebo when given concomitantly with chemoradiotherapy, or as maintenance therapy alone. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5134726 Sun, 07 Aug 2011 23:00:00 +0100 5134726 http://www.medworm.com/index.php?rid=5134716&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011003872%2Fabstract%3Frss%3Dyes ESTRO, the European Society for Therapeutic Radiation Oncology, or with its new name European Society for Radiation Oncology, is a scientific society. It means that the prime aim of ESTRO is to bring to bring people together on an individual basis who have a common interest in improving the scientific conduct of radiotherapy and cancer treatment in Europe by ensuring that proper radiotherapy is available in the multidisciplinary treatment of cancer and applied with the right indication and with the most optimal technique. One of the main aims of this endeavour was to create a platform for scientific exchange through meetings and through the establishment of a scientific journal . Thus Radiotherapy and Oncology was launched shortly after the foundation of ESTRO and has become the society’... Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5134716 Sun, 07 Aug 2011 23:00:00 +0100 5134716 http://www.medworm.com/index.php?rid=5187221&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011004725%2Fabstract%3Frss%3Dyes (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5187221 Sun, 31 Jul 2011 23:00:00 +0100 5187221 http://www.medworm.com/index.php?rid=5187189&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS016781401100449X%2Fabstract%3Frss%3Dyes This study was the first large-scale epidemiological study on irradiated breast cancer patients, and it prompted valuable research into the causes of this unexpected finding. The study was based on almost 8000 breast cancer patients included in eight clinical trials commenced before 1975 where patients after mastectomy were randomised to ± adjuvant radiotherapy. A later report from Cuzick et al. on the cause-specific mortality in these trials identified heart mortality as the primary reason for the excess mortality . Since these important reports from Cuzick et al. the heart has been considered an organ at risk (OAR) when planning adjuvant radiotherapy for breast cancer. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5187189 Sun, 31 Jul 2011 23:00:00 +0100 5187189 http://www.medworm.com/index.php?rid=5187188&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011004701%2Fabstract%3Frss%3Dyes (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5187188 Sun, 31 Jul 2011 23:00:00 +0100 5187188 http://www.medworm.com/index.php?rid=5187187&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011004695%2Fabstract%3Frss%3Dyes (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5187187 Sun, 31 Jul 2011 23:00:00 +0100 5187187 http://www.medworm.com/index.php?rid=5134732&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011003343%2Fabstract%3Frss%3Dyes Conclusions: For patients with a laryngeal carcinoma treated with RT alone, we have developed visual, easy-to-use nomograms for the prediction of overall survival and primary local control. These models have been successfully validated in four external centers. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5134732 Sun, 24 Jul 2011 23:00:00 +0100 5134732 http://www.medworm.com/index.php?rid=5434176&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011003410%2Fabstract%3Frss%3Dyes Abstract: Background and purpose: To evaluate whether FDG-PET performed for radiotherapy (RT) planning can detect disease progression, compared with staging PET.Materials and methods: Twenty-six patients with newly-diagnosed non-small-cell lung cancer underwent planning PET-CT for curative RT within 8weeks (mean: 33±14days) of staging PET-CT. Progressive disease (PD) was defined as >25% increase in tumour size (transaxial) or volume, as delineated by SUV threshold of 2.5, or new sites (SUV>2.5).Results: The planning PET detected PD in 16 patients (61%), compared to four patients (15%) by CT component of PET-CT. The mean scan interval was longer in patients with progression: 40±12days, compared to 22±11days without progression. Planning PET detected PD in 13/17 (76%), 12/14 (86%) and 7/7... Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5434176 Fri, 22 Jul 2011 04:00:00 +0100 5434176 http://www.medworm.com/index.php?rid=5134736&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011003392%2Fabstract%3Frss%3Dyes Abstract: Background and purpose: To characterise the incidence, pattern and severity of post cranial radiotherapy somnolence and to identify factors predictive of frequency and severity.Materials and methods: Seventy consecutive patients receiving radical cranial irradiation were prospectively assessed for somnolence at baseline, during and up to 10weeks following radiotherapy using five variables scored on a visual analogue scale (VAS) and the Littman scale. Fatigue was measured using the FACT-G score and quality of life using the EORTC QLQC30+3 with the brain tumour module questionnaire.Results: Ninety percent of patients experienced ⩾grade 1 somnolence (Littman score) and this correlated with VAS scores (r=0.456, p (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5134736 Thu, 21 Jul 2011 23:00:00 +0100 5134736 http://www.medworm.com/index.php?rid=5434168&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011003409%2Fabstract%3Frss%3Dyes Conclusion: Similar OS outcomes are achieved with surgery or SBRT for stage I NSCLC in elderly patients. Comorbidity data and outcomes from centralized surgical programs are needed for more robust conclusions. (Source: Radiotherapy and Oncology) Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5434168 Wed, 20 Jul 2011 04:00:00 +0100 5434168 http://www.medworm.com/index.php?rid=5391971&cid=s_38642_37_f&fid=38642&url=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FPIIS0167814011003331%2Fabstract%3Frss%3Dyes Abstract: Background: Overexpression of EGFR correlates with decreased survival after radiotherapy in head and neck squamous cell carcinoma (HNSCC). However, the contribution of the activated form, pEGFR, and its downstream signaling (PI3-K/AKT) pathway is not clear yet.Methods: Fifty-eight patients with HNSCC were included in the study. pEGFR, pAKT, hypoxia, and vessels were visualized using immunohistochemistry. Fractions (defined as the tumor area positive for the respective markers relative to the total tumor area) were calculated by automated image analysis and related to clinical outcome.Results: Both pEGFR (median 0.6%, range 0–34%) and pAKT (median 1.8%, range 0–16%) expression differed between tumors. Also, a large variation in hypoxia was found (median pimonidazole fraction 3... Radiotherapy and Oncology journals http://www.medworm.com/rss/comments.php?id=5391971 Wed, 20 Jul 2011 04:00:00 +0100 5391971