Revista Brasileira de Hematologia e Hemoterapia via MedWorm.com

---

Revista Brasileira de Hematologia e Hemoterapia — Fri, 20 Jan 2012 22:10:14 +0100

(Source: Revista Brasileira de Hematologia e Hemoterapia)

Bone marrow cytomorphological changes in patients co-infected with visceral leishmaniasis and human immunodeficiency virus

Revista Brasileira de Hematologia e Hemoterapia — Fri, 20 Jan 2012 22:10:14 +0100

Visceral leishmaniasis (VL) is a severe systemic infectious disease.(1) It has been recognized as an opportunistic disease in patients infected with human immunodeficiency virus (HIV).(2,3) The analysis of the bone marrow of patients co-infected with VL and HIV showed dysplasia of erythroid, granulocytic and megakaryocytic lineages (Figure 1), besides the presence of plasmacytosis, cytoplasmic bodies, hemophagocytosis, granuloma and intracellular and extracellular leishmania amastigotes (Figure 2). These findings are found in the analysis of bone marrow of patients co-infected with HIV and VL; knowledge of these findings may be useful for the diagnosis and prognosis of patients (Source: Revista Brasileira de Hematologia e Hemoterapia)

XmnI polymorphism frequency in heterozygote beta thalassemia subjects and its relation to Fetal hemoglobin levels

Revista Brasileira de Hematologia e Hemoterapia — Fri, 20 Jan 2012 22:10:14 +0100

We describe a case of an unusual presentation of acute promyelocytic leukemia. A 53 year-old male was admitted complaining of pain and weakness in his legs. He presented at examination a spastic paraparesis with a sensitive level at the eighth thoracic medullar (T8) segment. Magnetic resonance imaging showed a posterolateral extradural mass from T6 through T8 segments with medullar compression. A complete blood count showed anemia, thrombocytopenia and the presence of promyelocytes and blasts. Marrow examination was compatible with the diagnosis of acute promyelocytic leukemia by cytogenetics and polymerase chain reaction for the PML-RARα gene. He was treated with all-trans-retinoic acid therapy plus daunorubicin and presented an all-trans-retinoic acid syndrome. Despite hematological rem...

Exodontia in patient with Gaucher's disease

Revista Brasileira de Hematologia e Hemoterapia — Fri, 20 Jan 2012 22:10:14 +0100

Acute promyelocytic leukemia presenting as an extradural mass

Revista Brasileira de Hematologia e Hemoterapia — Fri, 20 Jan 2012 22:10:14 +0100

Thymoma followed by aplastic anemia: two different responses to immunosuppressive therapy

Revista Brasileira de Hematologia e Hemoterapia — Fri, 20 Jan 2012 22:10:14 +0100

Aplastic anemia is an uncommon complication of thymoma and is extremely infrequent after the surgical removal of a thymic tumor. Aplastic anemia is a result of marrow failure and is characterized by peripheral pancytopenia and severely depressed marrow cellularity; it may be an autoimmune manifestation of thymoma. As thymoma-associated hematological dyscrasias, which include pure red cell aplasia, aplastic anemia and myasthenia gravis, are supposed to be of immunologic origin, two cases of very severe aplastic anemia following the resection of lymphocytic thymomas treated with immunosuppression are herein presented (Source: Revista Brasileira de Hematologia e Hemoterapia)

Imatinib resistance: a review of alternative inhibitors in chronic myeloid leukemia

Revista Brasileira de Hematologia e Hemoterapia — Fri, 20 Jan 2012 22:10:14 +0100

This article, a review of possible therapies used to overcome imatinib resistance, investigates the current position by searching the PubMed electronic database using the following keywords: imatinib, dasatinib, nilotinib, aurora kinase, SRC kinase, mutation, treatment, drugs and resistance. New tyrosine kinase inhibitors include BCR-ABL kinase selective inhibitors, dual ABL/SRC kinase inhibitors and aurora kinase inhibitors. Awareness of the spectrum of new drugs against mutations, in particular the T315I mutation, makes it possible to properly select the best therapy for each patient (Source: Revista Brasileira de Hematologia e Hemoterapia)

Intravenous iron therapy: how far have we come?

Revista Brasileira de Hematologia e Hemoterapia — Fri, 20 Jan 2012 22:10:14 +0100

Oral iron supplementation is usually the first choice for the treatment of iron deficiency anemia (IDA) because of its effectiveness and low cost. But unfortunately in many iron deficient conditions, oral iron is a less than the ideal treatment mainly because of adverse events related to the gastrointestinal tract as well as the long course required to treat anemia and replenish body iron stores. The first iron product for intravenous use was high-molecular-weight iron dextran. However, dextran-containing intravenous iron preparations are associated with an elevated risk of anaphylactic reactions, which made physicians reluctant to prescribe intravenous iron in the treatment of iron deficiency anemia for many years. In 1999 and 2001, two new intravenous iron preparations (ferric gluconate ...

The significance of major and stable molecular responses in chronic myeloid leukemia in the tyrosine kinase inhibitor era

Revista Brasileira de Hematologia e Hemoterapia — Fri, 20 Jan 2012 22:10:14 +0100

Tyrosine kinase inhibitors have changed the management and outcomes of chronic myeloid leukemia patients. Quantitative polymerase chain reaction is used to monitor molecular responses to tyrosine kinase inhibitors. Molecular monitoring represents the most sensitive tool to judge chronic myeloid leukemia disease course and allows early detection of relapse. Evidence of achieving molecular response is important for several reasons: 1. early molecular response is associated with major molecular response rates at 18-24 months; 2. patients achieving major molecular response are less likely to lose their complete cytogenetic response; 3. a durable, stable major molecular response is associated with increased progression-free survival. However, standardization of molecular techniques is still cha...

Hematology in Latin America: where are we? analysis of the reports of Societies of Hematology associated organization of the Highlights of ASH in Latin America

Revista Brasileira de Hematologia e Hemoterapia — Fri, 20 Jan 2012 22:10:14 +0100

CONCLUSION: The O blood group phenotype is associated with allergic rhinitis in male but not in female patients (Source: Revista Brasileira de Hematologia e Hemoterapia)

Evidence of an association between the O blood group and allergic rhinitis

Revista Brasileira de Hematologia e Hemoterapia — Fri, 20 Jan 2012 22:10:14 +0100

CONCLUSION: The O blood group phenotype is associated with allergic rhinitis in male but not in female patients (Source: Revista Brasileira de Hematologia e Hemoterapia)

Efficacy and safety of intravenous iron sucrose in treating adults with iron deficiency anemia

Revista Brasileira de Hematologia e Hemoterapia — Fri, 20 Jan 2012 22:10:14 +0100

CONCLUSIONS: Our data confirm that the use of intravenous iron sucrose is a safe and effective option in the treatment of adult patients with iron deficiency anemia who lack satisfactory response to oral iron therapy. Intravenous iron sucrose is well tolerated and with a clinically manageable safety profile when using appropriate dosing and monitoring. The availability of intravenous iron sucrose would potentially improve compliance and thereby reduce morbidities from iron deficiency (Source: Revista Brasileira de Hematologia e Hemoterapia)

Brazilian experience using high dose sequential chemotherapy followed by autologous hematopoietic stem cell transplantation for malignant lymphomas

Revista Brasileira de Hematologia e Hemoterapia — Fri, 20 Jan 2012 22:10:14 +0100

CONCLUSIONS: Despite a greater prevalence of poor prognostic factors, our results are comparable to the literature. The incidence of secondary neoplasias is noteworthy. Our study suggests that this approach is efficient and feasible, regardless of toxicity-related mortality (Source: Revista Brasileira de Hematologia e Hemoterapia)

Karyotypic and fluorescent in-situ hybridization study of the centromere of chromosome 7 in secondary myeloid neoplasms

Revista Brasileira de Hematologia e Hemoterapia — Fri, 20 Jan 2012 22:10:14 +0100

CONCLUSION: This study enhances the importance of cytogenetic analysis of patients at the time of diagnosis of secondary myeloid neoplasms (Source: Revista Brasileira de Hematologia e Hemoterapia)

Cytogenetics, JAK2 and MPL mutations in polycythemia vera, primary myelofibrosis and essential thrombocythemia

Revista Brasileira de Hematologia e Hemoterapia — Fri, 20 Jan 2012 22:10:14 +0100

CONCLUSIONS: This study demonstrates that karyotyping for JAK2 and MPL mutations is useful in the diagnosis of myeloproliferative neoplasms. The precise pathogenetic contribution of these alterations is still unclear. However, this study adds more information about the pathophysiology of polycythemia vera, essential thrombocythemia and primary myelofibrosis (Source: Revista Brasileira de Hematologia e Hemoterapia)

Mobilization of hematopoietic progenitor cells with granulocyte colony stimulating factors for autologous transplant in hematologic malignancies: a single center experience

Revista Brasileira de Hematologia e Hemoterapia — Fri, 20 Jan 2012 22:10:14 +0100

CONCLUSIONS: Among other factors, the origin of the cytokine used as mobilizing agent is an element to be considered when evaluating CD34+ cell mobilization results (Source: Revista Brasileira de Hematologia e Hemoterapia)

Clinical guidelines in Hematology

Revista Brasileira de Hematologia e Hemoterapia — Fri, 20 Jan 2012 22:10:14 +0100

(Source: Revista Brasileira de Hematologia e Hemoterapia)

Allergic rhinitis and association with the O blood group

Revista Brasileira de Hematologia e Hemoterapia — Fri, 20 Jan 2012 22:10:14 +0100

(Source: Revista Brasileira de Hematologia e Hemoterapia)

On the relevance of outpatient intravenous iron therapy for anemia management

Revista Brasileira de Hematologia e Hemoterapia — Fri, 20 Jan 2012 22:10:14 +0100

(Source: Revista Brasileira de Hematologia e Hemoterapia)

Secondary myeloid neoplasias: an emerging group of diseases

Revista Brasileira de Hematologia e Hemoterapia — Fri, 20 Jan 2012 22:10:14 +0100

(Source: Revista Brasileira de Hematologia e Hemoterapia)

The importance of cytogenetics in polycythemia vera, primary myelofibrosis and essential thrombocythemia

Revista Brasileira de Hematologia e Hemoterapia — Fri, 20 Jan 2012 22:10:14 +0100

(Source: Revista Brasileira de Hematologia e Hemoterapia)

Peripheral hematopoietic progenitor cell mobilization for autologous transplantation in hematologic malignancies

Revista Brasileira de Hematologia e Hemoterapia — Fri, 20 Jan 2012 22:10:14 +0100

(Source: Revista Brasileira de Hematologia e Hemoterapia)

The journal's performance in 2011

Revista Brasileira de Hematologia e Hemoterapia — Fri, 20 Jan 2012 22:10:14 +0100

(Source: Revista Brasileira de Hematologia e Hemoterapia)

Reticulocytes indices in β thalassemia trait individuals

Revista Brasileira de Hematologia e Hemoterapia — Fri, 25 Nov 2011 10:35:13 +0100

Aceruloplasminemia is a rare autosomal recessive disease in which a mutation leads to the absence or dysfunction of ceruloplasmin. Deficiency of this enzyme leads to the accumulation of iron in various organs; aceruloplasminemia is usually characterized by diabetes, retinal degeneration and neurological disorders. Diagnosis is suspected by the presence of elevated levels of ferritin, anemia, decreased serum copper and absence of ceruloplasmin in serum. Treatment of aceruloplasminemia is mainly based on the control of iron overload. (Source: Revista Brasileira de Hematologia e Hemoterapia)

Hematological reference ranges among healthy adults of Curitiba, PR, Brazil

Revista Brasileira de Hematologia e Hemoterapia — Fri, 25 Nov 2011 10:35:13 +0100

A report of WHIM syndrome (myelokathexis): clinical features and bone marrow morphology

Revista Brasileira de Hematologia e Hemoterapia — Fri, 25 Nov 2011 10:35:13 +0100

Aceruloplasminemia: a rare disease - diagnosis and treatment of two cases

Revista Brasileira de Hematologia e Hemoterapia — Fri, 25 Nov 2011 10:35:13 +0100

Epstein-Barr virus: general factors, virus-related diseases and measurement of viral load after transplant

Revista Brasileira de Hematologia e Hemoterapia — Fri, 25 Nov 2011 10:35:13 +0100

The Epstein-Barr virus is responsible for infectious mononucleosis syndrome and is also closely associated to several types of cancer. The main complication involving Epstein-Barr virus infection, both in recipients of hematopoietic stem cells and solid organs, is post-transplant lymphoproliferative disease. The importance of this disease has increased interest in the development of laboratory tools to improve post-transplant monitoring and to detect the disease before clinical evolution. Viral load analysis for Epstein-Barr virus through real-time polymerase chain reaction is, at present, the best tool to measure viral load. However, there is not a consensus on which sample type is the best for the test and what is its predictive value for therapeutic interventions. (Source: Revista Brasi...

Immunoglobulin: production, mechanisms of action and formulations

Revista Brasileira de Hematologia e Hemoterapia — Fri, 25 Nov 2011 10:35:13 +0100

Human immunoglobulin (Ig) began to be applied in the clinical practice with the treatment of primary immunodeficiencies. Quickly, applications of Ig increased, as its anti-inflammatory and immunomodulatory functions were elucidated. Currently, Ig is the most commonly used blood product. Ig is obtained by processing plasma; methods, in particular, techniques to reduce plasma viral loads have been evolving over the years and include: pasteurization, solvent/ detergent treatment, caprylic acid treatment and nanofiltration. These methods contribute to increased safety and quality of blood products. The mechanisms of action of Ig not only involve the blockade of Fc receptors of phagocytes, but also control complement pathways, idiotype-anti-idiotype dimer formation, blockage of superantigen bin...

Cytogenetic effect of 5-azacytidine in patients with hematological malignancies

Revista Brasileira de Hematologia e Hemoterapia — Fri, 25 Nov 2011 10:35:13 +0100

CONCLUSIONS: The results of this study suggest that satellite sequences, located in the heterochromatin of chromosome-9, are hypomethylated in hematological malignancies. This hypomethylation may contribute to the disease, activating transposable elements and/or promoting genomic instability, enabling the loss of heterozygosity of important tumor suppressor genes. An investigation of the 19q13 region may help to understand whether or not the predominant occurrence of the fragile site at 19q13 in controls is due to hypermethylation of this region. (Source: Revista Brasileira de Hematologia e Hemoterapia)

Evaluation of lymphocyte levels in a random sample of 218 elderly individuals from São Paulo city

Revista Brasileira de Hematologia e Hemoterapia — Fri, 25 Nov 2011 10:35:13 +0100

CONCLUSION: Elderly men present with more changes in lymphocyte subsets compared to elderly women. These findings could demonstrate impairment in the immune response since the lower CD4+ in men would provide less help to B cells (also lower in men) in terms of antibody production. In addition, the increase in CD8+ cells in this group could represent chronic inflammation observed during the aging process. (Source: Revista Brasileira de Hematologia e Hemoterapia)

Brazilian workshop model to train investigators in chronic graft-versus-host disease clinical trials according to the 2005-2006 National Institutes of Health recommendations

Revista Brasileira de Hematologia e Hemoterapia — Fri, 25 Nov 2011 10:35:13 +0100

CONCLUSIONS: Results of this workshop support the need to train investigators participating in clinical trials on chronic graft-versus-host disease. (Source: Revista Brasileira de Hematologia e Hemoterapia)

Langerhans cell histiocytosis: 37 cases in a single Brazilian institution

Revista Brasileira de Hematologia e Hemoterapia — Fri, 25 Nov 2011 10:35:13 +0100

CONCLUSION: The level of diagnostic accuracy was increased through immunohistochemistry. The overall survival rate was similar to international multicentric studies. Multisystem disease and absence of response at six weeks of treatment were the most important unfavorable prognostic factors. The frequency of reactivation for patients with multisystem disease was higher than described in the literature, probably because maintenance chemotherapy was used only in two cases. (Source: Revista Brasileira de Hematologia e Hemoterapia)

Effectiveness of confidential unit exclusion in screening blood donors of the regional blood bank in Londrina, Paraná State

Revista Brasileira de Hematologia e Hemoterapia — Fri, 25 Nov 2011 10:35:13 +0100

CONCLUSIONS: These results show that confidential unit exclusion used in this blood bank is effective and is inexpensive. However, the diagnostic power to detect blood-borne infections was low and resulted in the discard of a high number of blood bags without any direct or indirect serologic markers of pathogens. The use of confidential unit exclusion could be replaced with molecular tests to screen blood donors. (Source: Revista Brasileira de Hematologia e Hemoterapia)

HIV Seroconversion in blood donors from the coordinating blood bank in the State of Pará

Revista Brasileira de Hematologia e Hemoterapia — Fri, 25 Nov 2011 10:35:13 +0100

CONCLUSIONS: In order to improve the quality of blood and reduce the residual risk of HIV transmission in blood banks, it is necessary to know the profiles of donors who most frequently seroconvert and use nucleic acid amplification tests as routine screening. (Source: Revista Brasileira de Hematologia e Hemoterapia)

Analysis of immediate transfusion incidents reported in a regional blood bank

Revista Brasileira de Hematologia e Hemoterapia — Fri, 25 Nov 2011 10:35:13 +0100

CONCLUSIONS: Data from the present study corroborate the implementation of new professional training programs aimed at blood transfusion surveillance. These measures should emphasize prevention, identification and reporting of immediate transfusion incidents aiming to increase blood transfusion quality and safety. (Source: Revista Brasileira de Hematologia e Hemoterapia)

The Langerhans cell histiocytosis: a disease in search of an identity

Revista Brasileira de Hematologia e Hemoterapia — Fri, 25 Nov 2011 10:35:13 +0100

(Source: Revista Brasileira de Hematologia e Hemoterapia)

Comments on the evaluation of lymphocyte levels in a random sample of 218 elderly individuals from São Paulo city

Revista Brasileira de Hematologia e Hemoterapia — Fri, 25 Nov 2011 10:35:13 +0100

(Source: Revista Brasileira de Hematologia e Hemoterapia)

Comments on the Brazilian workshop model for training investigators in chronic graft-versus-host disease according to the 2005-2006 National Institutes of Health recommendations

Revista Brasileira de Hematologia e Hemoterapia — Fri, 25 Nov 2011 10:35:13 +0100

(Source: Revista Brasileira de Hematologia e Hemoterapia)

Effectiveness of confidential unit exclusion for screening blood donors

Revista Brasileira de Hematologia e Hemoterapia — Fri, 25 Nov 2011 10:35:13 +0100

(Source: Revista Brasileira de Hematologia e Hemoterapia)

The role of hemovigilance as a mechanism to increase transfusion safety

Revista Brasileira de Hematologia e Hemoterapia — Fri, 25 Nov 2011 10:35:13 +0100

(Source: Revista Brasileira de Hematologia e Hemoterapia)

Brazilian Society of Pediatric Oncology - SOBOPE: 30 years of history, a lot in the present, full of the future

Revista Brasileira de Hematologia e Hemoterapia — Fri, 25 Nov 2011 10:35:13 +0100

(Source: Revista Brasileira de Hematologia e Hemoterapia)

The Revista Brasileira de Hematologia e Hemoterapia now and discussion on the new classification of brazilian journals

Revista Brasileira de Hematologia e Hemoterapia — Fri, 25 Nov 2011 10:35:13 +0100

(Source: Revista Brasileira de Hematologia e Hemoterapia)

Noma-like lesion in a patient with acute promyelocytic leukemia

Revista Brasileira de Hematologia e Hemoterapia — Mon, 03 Oct 2011 09:40:58 +0100

Rosai-Dorfman disease is a self-limiting condition caused by histiocyte proliferation within the sinusoids of lymph nodes and in extranodal tissue. It is a rare disease, particularly in children, that progresses with extensive lymphadenopathy. This paper reports on the case of a 2-year-old child with progressive cervical lymphadenopathy associated with persistent fever and radiological findings suggestive of lymphoma. Histopathological and immunohistochemistry studies of a lymph node biopsy established the diagnosis of Rosai-Dorfman disease. Both lymphadenopathy and fever resolved spontaneously. (Source: Revista Brasileira de Hematologia e Hemoterapia)

Critical analysis of the neonatal screening program for hemoglobinopathies

Revista Brasileira de Hematologia e Hemoterapia — Mon, 03 Oct 2011 09:40:58 +0100

Prevalence of non-Hodgkin lymphomas in São Paulo, Brazil

Revista Brasileira de Hematologia e Hemoterapia — Mon, 03 Oct 2011 09:40:58 +0100

Four cases of Chédiak-Higashi syndrome

Revista Brasileira de Hematologia e Hemoterapia — Mon, 03 Oct 2011 09:40:58 +0100

Rosai-Dorfman disease with spontaneous resolution: case report of a child

Revista Brasileira de Hematologia e Hemoterapia — Mon, 03 Oct 2011 09:40:58 +0100

Neuroglobin and cytoglobin: two new members of globin family

Revista Brasileira de Hematologia e Hemoterapia — Mon, 03 Oct 2011 09:40:58 +0100

The globin family has long been defined by myoglobin and hemoglobin, proteins with the functions of oxygen storage and transportation, respectively. Recently, two new members of this family were discovered: neuroglobin present in neurons and retinal cells and cytoglobin found in various types of tissue. The increased expression of these proteins in hypoxic conditions first suggested a role in oxygen supply. However structural and functional differences, such as the hexacoordinated heme, a high autoxidation rate and different concentrations between different cellular types, have dismissed this hypothesis. The protective role of these globins has already been established. In vitro and in vivo studies have demonstrated increased survival of neurons under stress in the presence of neuroglobin ...

Monitoring imatinib plasma concentrations in chronic myeloid leukemia

Revista Brasileira de Hematologia e Hemoterapia — Mon, 03 Oct 2011 09:40:58 +0100

Imatinib has proved to be effective in the treatment of chronic myeloid leukemia, but plasma levels above 1,000 ng/mL must be achieved to optimize activity. Therapeutic drug monitoring of imatinib is useful for patients that do not present clinical response. There are several analytical methods to measure imatinib in biosamples, which are mainly based on liquid chromatography with mass spectrometric or diode array spectrophotometric detection. The former is preferred due to its lower cost and wider availability. The present manuscript presents a review of the clinical and analytical aspects of the therapeutic drug monitoring of imatinib in the treatment of chronic myeloid leukemia. The review includes references published over the last 10 years. There is evidence that the monitoring of pla...

Electrical properties of the red blood cell membrane and immunohematological investigation

Revista Brasileira de Hematologia e Hemoterapia — Mon, 03 Oct 2011 09:40:58 +0100

Hemagglutination is widely used in transfusion medicine and depends on several factors including antigens, antibodies, electrical properties of red blood cells and the environment of the reaction. Intermolecular forces are involved in agglutination with cell clumping occurring when the aggregation force is greater than the force of repulsion. Repulsive force is generated by negative charges on the red blood cell surface that occur due to the presence of the carboxyl group of sialic acids in the cell membrane; these charges create a repulsive electric zeta potential between cells. In transfusion services, specific solutions are used to improve hemagglutination, including enzymes that reduce the negative charge of red blood cells, LISS which improves the binding of antibodies to antigens and...

Molecular approach to diagnose BCR/ABL negative chronic myeloproliferative neoplasms

Revista Brasileira de Hematologia e Hemoterapia — Mon, 03 Oct 2011 09:40:58 +0100

Chronic myeloproliferative neoplasms arise from clonal proliferation of hematopoietic stem cells. According to the World Health Organization myeloproliferative neoplasms are classified as: chronic myelogenous leukemia, polycythemia vera, essential thrombocythemia, primary myelofibrosis, chronic neutrophilic leukemia, chronic eosinophilic leukemia, hypereosinophilic syndrome, mast cell disease, and unclassifiable myeloproliferative neoplasms. In the revised 2008 WHO diagnostic criteria for myeloproliferative neoplasms, mutation screening for JAK2V617F is considered a major criterion for polycythemia vera diagnosis and also for essential thrombocythemia and primary myelofibrosis, the presence of this mutation represents a clonal marker. There are currently two hypotheses explaining the role ...

A multicenter feasibility study of chronic graft-versus-host disease according to the National Institute of Health criteria: efforts to establish a Brazil-Seattle consortium as a platform for future collaboration in clinical trials

Revista Brasileira de Hematologia e Hemoterapia — Mon, 03 Oct 2011 09:40:58 +0100

CONCLUSIONS: It was feasible to use the National Institute of Health consensus criteria for the diagnosis and scoring of chronic graft-versus-host disease in a Brazilian prospective multicenter study. More importantly, a collaborative hematopoietic cell transplantation network was established in Brazil offering new opportunities for future clinical trials in chronic graft-versus-host disease and in other areas of research involving hematopoietic stem cell transplantation. (Source: Revista Brasileira de Hematologia e Hemoterapia)

Quality of assistance provided to children with sickle cell disease by primary healthcare services

Revista Brasileira de Hematologia e Hemoterapia — Mon, 03 Oct 2011 09:40:58 +0100

CONCLUSION: The quality of healthcare is unsatisfactory. The care provided to children with sickle cell disease in primary healthcare services needs improvements. (Source: Revista Brasileira de Hematologia e Hemoterapia)

Analysis of the -398C/T polymorphism in the perforin gene in oncohematological patients

Revista Brasileira de Hematologia e Hemoterapia — Mon, 03 Oct 2011 09:40:58 +0100

CONCLUSION:One patient was homozygous for the -398T allele. Based on these findings, further studies should be conducted to assess whether the presence of this polymorphism may be a risk factor for the development of hematologic malignancies. (Source: Revista Brasileira de Hematologia e Hemoterapia)

Quantification of CD8+CD38+ T lymphocytes by flow cytometry does not represent a good biomarker to monitor the reactivation of cytomegalovirus infection after allogeneic hematopoietic stem cell transplantation

Revista Brasileira de Hematologia e Hemoterapia — Mon, 03 Oct 2011 09:40:58 +0100

CONCLUSIONS: This study suggests that the investigation of these lymphocyte sub-populations in patients submitted to hematopoietic stem cell transplantation does not seem to contribute to the early identification of cytomegalovirus disease. (Source: Revista Brasileira de Hematologia e Hemoterapia)

Confidential donation confirmation as an alternative to confidential unit exclusion: 15 months experience of the HEMOMINAS foundation

Revista Brasileira de Hematologia e Hemoterapia — Mon, 03 Oct 2011 09:40:58 +0100

CONCLUSION: Our findings suggest that there are not enough benefits to justify continued use of confidential donation confirmation in the analyzed institution. (Source: Revista Brasileira de Hematologia e Hemoterapia)

Titers of ABO antibodies in group O blood donors

Revista Brasileira de Hematologia e Hemoterapia — Mon, 03 Oct 2011 09:40:58 +0100

CONCLUSION: This study confirms that over 50-year-old O group men should be selected as blood donors in non-identical ABO transfusion situations. Also, titration of ABO antibodies in blood banks will increase safety in non-identical ABO transfusions. (Source: Revista Brasileira de Hematologia e Hemoterapia)

Therapeutic drug monitoring of imatinib

Revista Brasileira de Hematologia e Hemoterapia — Mon, 03 Oct 2011 09:40:58 +0100

(Source: Revista Brasileira de Hematologia e Hemoterapia)

Progress in chronic graft-versus-host disease

Revista Brasileira de Hematologia e Hemoterapia — Mon, 03 Oct 2011 09:40:58 +0100

(Source: Revista Brasileira de Hematologia e Hemoterapia)

Perforin and hematological cancer

Revista Brasileira de Hematologia e Hemoterapia — Mon, 03 Oct 2011 09:40:58 +0100

(Source: Revista Brasileira de Hematologia e Hemoterapia)

Special features of quantification of CD8+CD38+ T-cells by flow cytometry does not represent a good biomarker to monitor the reactivation of cytomegalovirus infection after allogeneic hematopoietic stem cell transplantation

Revista Brasileira de Hematologia e Hemoterapia — Mon, 03 Oct 2011 09:40:58 +0100

(Source: Revista Brasileira de Hematologia e Hemoterapia)

Confidential donation confirmation as a alternative exclusion

Revista Brasileira de Hematologia e Hemoterapia — Mon, 03 Oct 2011 09:40:58 +0100

(Source: Revista Brasileira de Hematologia e Hemoterapia)

Titers of ABO antibodies in group O blood donors: patient safety and blood product supply remain a challenge

Revista Brasileira de Hematologia e Hemoterapia — Mon, 03 Oct 2011 09:40:58 +0100

(Source: Revista Brasileira de Hematologia e Hemoterapia)

The evolution of drug therapy and the challenges to physicians, patients and healthcare systems

Revista Brasileira de Hematologia e Hemoterapia — Mon, 03 Oct 2011 09:40:58 +0100

(Source: Revista Brasileira de Hematologia e Hemoterapia)

Iron health: where are we and where are we going?

Revista Brasileira de Hematologia e Hemoterapia — Wed, 10 Aug 2011 18:41:51 +0100

Hematopoietic stem cell transplantation from haploidentical donors is an attractive method of transplantation due to the immediate donor availability, ease of stem cell procurement and the possibility to collect additional donor cells for cellular therapy, if needed. Historically, maintaining T-cells in the graft has been associated with very high rates of graft-versus-host disease, while T-cell depleted haploidentical transplantation has been limited by a higher incidence of graft rejection and delayed immune reconstitution post-transplant. Recent approaches attempt to maintain the T-cells in the graft while effectively preventing the development of graft-versus-host disease post-transplant. Selective depletion of alloreactive T-cells post-transplant using high-dose post-transplant cyclop...

Iron deficiency anemia and its treatment: reply

Revista Brasileira de Hematologia e Hemoterapia — Wed, 10 Aug 2011 18:41:51 +0100

Interaction between Hb SS and alpha thalassemia (3.7 kb deletion): a familial study

Revista Brasileira de Hematologia e Hemoterapia — Wed, 10 Aug 2011 18:41:51 +0100

Iron deficiency anemia and its treatment

Revista Brasileira de Hematologia e Hemoterapia — Wed, 10 Aug 2011 18:41:51 +0100

Monitoring strategy as a tool for blood transfusion safety

Revista Brasileira de Hematologia e Hemoterapia — Wed, 10 Aug 2011 18:41:51 +0100

Advances in haploidentical stem cell transplantation

Revista Brasileira de Hematologia e Hemoterapia — Wed, 10 Aug 2011 18:41:51 +0100

What influences Hb fetal production in adulthood?

Revista Brasileira de Hematologia e Hemoterapia — Wed, 10 Aug 2011 18:41:51 +0100

Human hemoglobin genes are located in α and β globin gene clusters in chromosomes 16 and 11, respectively. Different types of hemoglobin are synthesized according to the stage of development with fetal hemoglobin (α2γ2) (Hb F) being the main hemoglobin in the fetal period. After birth, there is a reduction (to about 1%) in Hb F levels and adult hemoglobin, Hb A (2α2β2), increases to more than 96% of total hemoglobin. However, some genetic conditions whether linked to the β-globin gene cluster or not are associated with high Hb F levels in adults. Among those linked to β-globin are hereditary persistence of fetal hemoglobin, delta-beta thalassemia (δβ-Thalassemia) and the XmnI polymorphism (-158 C > T). Other polymorphisms not related to β-globin gene cluster are known to influen...

Clinical applications of immunoglobulin: update

Revista Brasileira de Hematologia e Hemoterapia — Wed, 10 Aug 2011 18:41:51 +0100

Human immunoglobulin is the most used blood product in the clinical practice. Immunoglobulin applications have increased quickly since the elucidation of its immunomodulatory and antiinflammatory properties which turned this blood product into a precious tool in the treatment of numerous diseases that present with humoral immune deficiency or that cause immune system dysfunction. Currently, the approved indications for Ig are: primary immunodeficiencies, secondary immunodeficiencies (multiple myeloma or chronic lymphoid leukemia), Kawasaki syndrome, immune thrombocytopenic purpura, Guillain Barré syndrome, graft-versus-host disease following bone marrow transplantation and repeat infections in HIV children. On the other hand, there are numerous "off-label" indications of immunoglobulin, w...

The role of natural killer cells in chronic myeloid leukemia

Revista Brasileira de Hematologia e Hemoterapia — Wed, 10 Aug 2011 18:41:51 +0100

Chronic myeloid leukemia is a neoplasia resulting from a translocation between chromosomes 9 and 22 producing the BCR-ABL hybrid known as the Philadelphia chromosome (Ph). In chronic myeloid leukemia a proliferation of malignant myeloid cells occurs in the bone marrow due to excessive tyrosine kinase activity. In order to maintain homeostasis, natural killer cells, by means of receptors, identify the major histocompatibility complex on the surface of tumor cells and subsequently induce apoptosis. The NKG2D receptor in the natural killer cells recognizes the transmembrane proteins related to major histocompatibility complex class I chain-related genes A and B (MICA and MICB), and it is by the interaction between NKG2D and MICA that natural killer cells exert cytotoxic activity against chron...

Monitoring of BCR-ABL levels in chronic myeloid leukemia patients treated with imatinib in the chronic phase: the importance of a major molecular response

Revista Brasileira de Hematologia e Hemoterapia — Wed, 10 Aug 2011 18:41:51 +0100

CONCLUSION: In conclusion, the prognostic impact of achieving complete cytogenetic response and a major molecular response and also the importance of molecular monitoring in the follow-up of chronic myeloid leukemia patients were demonstrated. (Source: Revista Brasileira de Hematologia e Hemoterapia)

Analysis of oxidative status and biochemical parameters in adult patients with sickle cell anemia treated with hydroxyurea, Ceará, Brazil

Revista Brasileira de Hematologia e Hemoterapia — Wed, 10 Aug 2011 18:41:51 +0100

CONCLUSION: These results indicate that hydroxyurea possibly acts as an antioxidant by increasing glutathione levels. (Source: Revista Brasileira de Hematologia e Hemoterapia)

The expression of CD56 antigen is associated with poor prognosis in patients with acute myeloid leukemia

Revista Brasileira de Hematologia e Hemoterapia — Wed, 10 Aug 2011 18:41:51 +0100

CONCLUSIONS: The data suggest that expression of CD56 in acute myeloid leukemia may be indicative of poor prognosis because it is associated with a shorter overall survival. The death rate during induction was not significantly different despite an apparent difference in proportions between groups. (Source: Revista Brasileira de Hematologia e Hemoterapia)

Hematological and immunological effects of stress of air traffic controllers in northeastern Brazil

Revista Brasileira de Hematologia e Hemoterapia — Wed, 10 Aug 2011 18:41:51 +0100

BACKGROUND: Several studies have shown that stress and emotional reactions can affect immune responses in animals and humans. OBJECTIVE: The aim of this study was to evaluate hematological and immunological effects of stress on air traffic controllers. METHODS: Thirty air traffic controllers and 15 aeronautical information service operators were evaluated. The groups were divided as information service operators with 10 years or more of experience (AIS>10) and with less than 10 years in the profession (AIS

Evaluation of the return rate of volunteer blood donors

Revista Brasileira de Hematologia e Hemoterapia — Wed, 10 Aug 2011 18:41:51 +0100

CONCLUSIONS: The low percentage of first-time donors who return for further blood donation reinforces the need for marketing actions and strategies aimed at increasing the return rates. (Source: Revista Brasileira de Hematologia e Hemoterapia)

Compliance with a protocol for acute lymphoblastic leukemia in childhood

Revista Brasileira de Hematologia e Hemoterapia — Wed, 10 Aug 2011 18:41:51 +0100

CONCLUSIONS: Compliance to the therapeutic protocol by both doctors and patients should always be considered in the evaluation of therapeutic failure in acute lymphoblastic leukemia; strict adherence to treatment protocols contributes to better treatment results in acute lymphoblastic leukemia children. (Source: Revista Brasileira de Hematologia e Hemoterapia)

Busulfan and melphalan as conditioning regimen for allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia in first complete remission

Revista Brasileira de Hematologia e Hemoterapia — Wed, 10 Aug 2011 18:41:51 +0100

CONCLUSION: The busulfan and melphalan conditioning regimen is as good as other conditioning regimens providing an excellent survival rate. (Source: Revista Brasileira de Hematologia e Hemoterapia)

Oxidative status in sickle cell anemia

Revista Brasileira de Hematologia e Hemoterapia — Wed, 10 Aug 2011 18:41:51 +0100

(Source: Revista Brasileira de Hematologia e Hemoterapia)

The expression of the CD56 antigen is associated with poor prognosis in patients with acute myeloid leukemia

Revista Brasileira de Hematologia e Hemoterapia — Wed, 10 Aug 2011 18:41:51 +0100

(Source: Revista Brasileira de Hematologia e Hemoterapia)

A brief explanation of the air traffic controller professional activity

Revista Brasileira de Hematologia e Hemoterapia — Wed, 10 Aug 2011 18:41:51 +0100

(Source: Revista Brasileira de Hematologia e Hemoterapia)

Retention of blood donors: strategies to fulfill the requirements of blood centers

Revista Brasileira de Hematologia e Hemoterapia — Wed, 10 Aug 2011 18:41:51 +0100

(Source: Revista Brasileira de Hematologia e Hemoterapia)

Compliance and adherence of patients in the treatment of acute lymphoblastic leukemia

Revista Brasileira de Hematologia e Hemoterapia — Wed, 10 Aug 2011 18:41:51 +0100

(Source: Revista Brasileira de Hematologia e Hemoterapia)

Conditioning regimen using busulfan plus melphalan in hematopoietic stem cell transplantation: can this conditioning regimen be used in autologous or allogeneic transplantation for acute leukemia?

Revista Brasileira de Hematologia e Hemoterapia — Wed, 10 Aug 2011 18:41:51 +0100

(Source: Revista Brasileira de Hematologia e Hemoterapia)

Countries emerging as major scientific powers

Revista Brasileira de Hematologia e Hemoterapia — Wed, 10 Aug 2011 18:41:51 +0100

(Source: Revista Brasileira de Hematologia e Hemoterapia)

Rev Bras Hematol Hemoter. 2011;33(1)

Revista Brasileira de Hematologia e Hemoterapia — Sat, 18 Jun 2011 17:47:17 +0100

Government health authorities approved, in December 2002, the ANVISA (National Sanitary Vigilance Agency) resolution number 344, making the addition of iron and folic acid to all wheat and maize flours industrialized in Brazil obligatory. After a brief review of iron deficiency, iron overload and folic acid deficiency several questions and remarks need to be made about this universal food fortification program. Iron salts and folic acid are drugs widely used in medicine and they may present undesirable side effects. There are potential risks with offering iron to the normal population for a long period of time and to patients with iron overload. Other important remarks are: there is no medical follow up of this treatment in the Brazilian population; patients can decide the quantity of food...

Acid phosphatase in blood smears of Phrynops geoffroanus (Testudines: Chelidae)

Revista Brasileira de Hematologia e Hemoterapia — Sat, 18 Jun 2011 17:47:17 +0100

Platelet indices: laboratory and clinical applications

Revista Brasileira de Hematologia e Hemoterapia — Sat, 18 Jun 2011 17:47:17 +0100

Considerations on the food fortification policy in Brazil

Revista Brasileira de Hematologia e Hemoterapia — Sat, 18 Jun 2011 17:47:17 +0100

Histiocytic sarcoma

Revista Brasileira de Hematologia e Hemoterapia — Sat, 18 Jun 2011 17:47:17 +0100

A 59-year-old white woman, SC, after being treated for pneumonia, presented with an increase in the size of lymph nodes. The immunohistochemical examination diagnosed histiocytic sarcoma. Relapse occurred 12 months after starting chemotherapy. The patient evolved with febrile neutropenia, septic shock and death. (Source: Revista Brasileira de Hematologia e Hemoterapia)

Hematological abnormalities and 22q11.2 deletion syndrome

Revista Brasileira de Hematologia e Hemoterapia — Sat, 18 Jun 2011 17:47:17 +0100

The 22q11.2 deletion syndrome (22q11DS) is a common genetic disease characterized by broad phenotypic variability. Despite the small number of studies describing hematological alterations in individuals with 22q11DS, it appears that these abnormalities are more frequent than previously imagined. Thus, the objective of our study was to report on a patient with 22q11DS presenting thrombocytopenia and large platelets and to review the literature. The patient, a 13-year-old boy, was originally evaluated due to craniofacial dysmorphia and speech delay. He also had a history of behavioral changes, neuropsychomotor delay and recurrent otitis/sinusitis. The identification of a 22q11.2 microdeletion by fluorescent in situ hybridization diagnosed the syndrome. Despite his hematological alterations, ...

Disease progression after R-CHOP treatment associated with the loss of CD20 antigen expression

Revista Brasileira de Hematologia e Hemoterapia — Sat, 18 Jun 2011 17:47:17 +0100

A case of a follicular lymphoma transformed into a CD20+ is described which progressed with the loss of CD20 expression after 8 cycles of R-CHOP. This phenomenon is not a rare event and has shown poor prognosis. Our purposes are to describe this event and suggest biopsy in relapsed or progressive disease. (Source: Revista Brasileira de Hematologia e Hemoterapia)

Current status of PET/CT in the diagnosis and follow up of lymphomas

Revista Brasileira de Hematologia e Hemoterapia — Sat, 18 Jun 2011 17:47:17 +0100

Lymphomas are a heterogeneous group of malignancies that have a distinct biological behavior according to the subtype and degree of differentiation. Adequate staging, which has a direct impact on prognosis, is essential to properly plan therapy. Structural cross-sectional imaging, such as computed tomography, has been the standard imaging tool to stage and monitor patients with lymphoma. However, molecular imaging such as positron emission tomography has shown complementary diagnostic and prognostic values. This review discusses the current value of positron emission tomography imaging using 2-[fluorine-18]fluoro-2-deoxy-d-glucose in staging, restaging, monitoring and detecting relapse in Hodgkin's and non-Hodgkin lymphoma. (Source: Revista Brasileira de Hematologia e Hemoterapia)

Dasatinib: clinical trials and management of adverse events in imatinib resistant/intolerant chronic myeloid leukemia

Revista Brasileira de Hematologia e Hemoterapia — Sat, 18 Jun 2011 17:47:17 +0100

This article reviews the results of phase I, II and III studies and looks at the efficacy and safety of dasatinib. This review also provides practical recommendations for the management of side effects. (Source: Revista Brasileira de Hematologia e Hemoterapia)

Importance of killer immunoglobulin-like receptors in allogeneic hematopoietic stem cell transplantation

Revista Brasileira de Hematologia e Hemoterapia — Sat, 18 Jun 2011 17:47:17 +0100

Hematopoietic stem cell transplantation is the treatment of choice for many hematologic diseases, such as multiple myeloma, bone marrow aplasia and leukemia. Human leukocyte antigen (HLA) compatibility is an important tool to prevent post-transplant complications such as graft rejection and graft-versus-host disease, but the high rates of relapse limit the survival of transplant patients. Natural Killer cells, a type of lymphocyte that is a key element in the defense against tumor cells, cells infected with viruses and intracellular microbes, have different receptors on their surfaces that regulate their cytotoxicity. Killer immunoglobulin-like receptors are the most important, interacting consistently with human leukocyte antigen class I molecules present in other cells and thus controlli...

Oncohematological diseases in the Vale do Paraíba, State of São Paulo: demographic aspects, prevalences and incidences

Revista Brasileira de Hematologia e Hemoterapia — Sat, 18 Jun 2011 17:47:17 +0100

CONCLUSION: Giving the paucity of data in this field of investigation, our data may be useful for comparisons with those of other regions of Brazil and will assist in the implementation of treatment programs of oncohematological diseases in this region. (Source: Revista Brasileira de Hematologia e Hemoterapia)

Emergency care necessity for sickle cell disease patients at Rio de Janeiro State Coordinating Blood Bank

Revista Brasileira de Hematologia e Hemoterapia — Sat, 18 Jun 2011 17:47:17 +0100

This study was developed with the aim of characterizing the emergency assistance required by sickle cell disease patients registered in the blood bank from January 2007 to December 2008. A retrospective study of medical records was made of 78, mostly children, patients from the date of their registration until December 2009. Most attendances (63.7%) were not considered emergency care. The use of specialized services for cases that do not require this level of complexity may saturate the capacity of these centers. However, delay of intervention for complications due to the transportation of patients to specialist centers may lead to deterioration in the clinical condition. (Source: Revista Brasileira de Hematologia e Hemoterapia)

Platelet aggregation and quality control of platelet concentrates produced in the Amazon Blood Bank

Revista Brasileira de Hematologia e Hemoterapia — Sat, 18 Jun 2011 17:47:17 +0100

CONCLUSION: Although the results were within the norms required by law, platelet concentrates had low aggregation rates. We suggest the inclusion of a functional assessment test for the quality control of platelet concentrates for a more effective response to platelet replacement therapy. (Source: Revista Brasileira de Hematologia e Hemoterapia)

Patients with sickle cell disease taking hydroxyurea in the Hemocentro Regional de Montes Claros

Revista Brasileira de Hematologia e Hemoterapia — Sat, 18 Jun 2011 17:47:17 +0100

CONCLUSION: Most patients showed improvements with treatment as demonstrated by increases in hemoglobin, fetal hemoglobin and mean corpuscular volume, as well as by reductions in the reticulocyte and white blood cell counts. Clinically, more than 50% of patients had a significant reduction of events. (Source: Revista Brasileira de Hematologia e Hemoterapia)

Prevalence of anemia in under five-year-old children in a children's hospital in Recife, Brazil

Revista Brasileira de Hematologia e Hemoterapia — Sat, 18 Jun 2011 17:47:17 +0100

CONCLUSION: The high prevalence of anemia suggests that it may contribute as a causal factor for hospitalization, especially because the period of hospitalization was short and the patient was likely to be anemic at the time of admission. This study stresses the importance of evaluating the overall nutritional status of patients, including their ingestion of microelements. This is especially important in children, because of their greater susceptibility to anemia. Measures directed at the prevention and control of anemia, including increased coverage of supplementation and fortification programs are strongly recommended. (Source: Revista Brasileira de Hematologia e Hemoterapia)

Association between anemia and subclinical infection in children in Paraíba State, Brazil

Revista Brasileira de Hematologia e Hemoterapia — Sat, 18 Jun 2011 17:47:17 +0100

CONCLUSION: Anemia is associated with subclinical infection in this population, indicating that this is an important variable to be considered in studies of the prevalence of anemia in children. (Source: Revista Brasileira de Hematologia e Hemoterapia)

Enrichment of iron and folic acid: the real need and the dangers of this initiative

Revista Brasileira de Hematologia e Hemoterapia — Sat, 18 Jun 2011 17:47:17 +0100

(Source: Revista Brasileira de Hematologia e Hemoterapia)

Comprehensive healthcare for individuals with sickle cell disease: a constant challenge

Revista Brasileira de Hematologia e Hemoterapia — Sat, 18 Jun 2011 17:47:17 +0100

(Source: Revista Brasileira de Hematologia e Hemoterapia)

Anemia and infection: a complex relationship

Revista Brasileira de Hematologia e Hemoterapia — Sat, 18 Jun 2011 17:47:17 +0100

(Source: Revista Brasileira de Hematologia e Hemoterapia)

Results and goals

Revista Brasileira de Hematologia e Hemoterapia — Sat, 18 Jun 2011 17:47:17 +0100

(Source: Revista Brasileira de Hematologia e Hemoterapia)

Santiago Pavlovsky

Revista Brasileira de Hematologia e Hemoterapia — Tue, 19 Apr 2011 17:41:19 +0100

We report on a rare case of multiple myeloma with atypically large cells containing a great amount of azurophilic inclusions usually seen in storage diseases (Source: Revista Brasileira de Hematologia e Hemoterapia)

Professor Pedro Clóvis Junqueira

Revista Brasileira de Hematologia e Hemoterapia — Tue, 19 Apr 2011 17:41:19 +0100

Multiple myeloma with cells typically seen in storage diseases

Revista Brasileira de Hematologia e Hemoterapia — Tue, 19 Apr 2011 17:41:19 +0100

The transfusion medicine we want

Revista Brasileira de Hematologia e Hemoterapia — Tue, 19 Apr 2011 17:41:19 +0100

Both multicentric Castleman disease and Kaposi sarcoma are more frequently observed in HIV infected patients. The coexistence of these Human herpesvirus 8 related lesions, in the same tissue, has been observed, but literature reports are scant. On the other hand, the expression of HHV-8-LANA-1 is easily demonstrable by immunohistochemistry. This has been shown to be a powerful tool for the diagnosis of these entities. The aim of this report is to communicate our experience with a case of multicentric Castleman disease occurring in the setting of HIV infection, which demonstrated microscopic Kaposi sarcoma in the same lymph node during the pathological work-up (Source: Revista Brasileira de Hematologia e Hemoterapia)

Simultaneous lymph node involvement by Castleman disease and Kaposi sarcoma

Revista Brasileira de Hematologia e Hemoterapia — Tue, 19 Apr 2011 17:41:19 +0100

Importance of monitoring and early switch to second generation tyrosine kinase inhibitors for the prognosis of patients with chronic myeloid leukemia with imatinib resistance or intolerance

Revista Brasileira de Hematologia e Hemoterapia — Tue, 19 Apr 2011 17:41:19 +0100

Imatinib mesylate was the first BCR-ABL-target agent approved for the treatment of chronic myeloid leukemia. Although most patients respond well to imatinib therapy, the literature shows that one third develops resistance or intolerance. The timing of second-line treatment after failure of initial treatment may have a significant impact on long-term outcome. Thus, appropriate monitoring to identify resistance and/or intolerance is crucial to early intervention with second generation tyrosine kinase inhibitors and attainment of better results (Source: Revista Brasileira de Hematologia e Hemoterapia)

Duffy blood group system and the malaria adaptation process in humans

Revista Brasileira de Hematologia e Hemoterapia — Tue, 19 Apr 2011 17:41:19 +0100

Malaria is an acute infectious disease caused by the protozoa of the genus Plasmodium. The antigens of the Duffy Blood Group System, in addition to incompatibilities in transfusions and hemolytic disease of the newborn, are of great interest in medicine due to their association with the invasion of red blood cells by the parasite Plasmodium vivax. For invasions to occur an interaction between the parasites and antigens of the Duffy Blood Group System is necessary. In Caucasians six antigens are produced by the Duffy locus (Fya, Fyb, F3, F4, F5 and F6). It has been observed that Fy(a-b-) individuals are resistant to Plasmodium knowlesi and P. vivax infection, because the invasion requires at least one of these antigens. The P. vivax Duffy Binding Protein (PvDBP) is functionally important in...

Prevalence of sickle cell disease and sickle cell trait in national neonatal screening studies

Revista Brasileira de Hematologia e Hemoterapia — Tue, 19 Apr 2011 17:41:19 +0100

Conclusion: Neonatal screening for Hb S is a very useful method to assess the prevalence of sickle cell trait (Hb AS) and sickle cell anemia (Hb SS) in Brazil. There is a heterogeneous distribution of this disease with the highest prevalence in the northeastern region and the lowest prevalence in the south. (Source: Revista Brasileira de Hematologia e Hemoterapia)

Brazilian Guidelines for transcranial doppler in children and adolescents with sickle cell disease

Revista Brasileira de Hematologia e Hemoterapia — Tue, 19 Apr 2011 17:41:19 +0100

CONCLUSION: The Brazilian guidelines on the use of transcranial doppler in sickle cell disease patients may reduce the risk of strokes, and thus reduce the morbidity and mortality and improve the quality of life of sickle cell disease patients. (Source: Revista Brasileira de Hematologia e Hemoterapia)

Epidemiology of hepatitis B virus infection in first-time blood donors in the southwestern region of Goiás, central Brazil

Revista Brasileira de Hematologia e Hemoterapia — Tue, 19 Apr 2011 17:41:19 +0100

CONCLUSION: The findings of low hepatitis B immunization coverage and the association of hepatitis B with risky behavior highlight that there is a need to intensify hepatitis B prevention programs in the southwest region of Goiás. (Source: Revista Brasileira de Hematologia e Hemoterapia)

Frequency of paroxysmal nocturnal hemoglobinuria in patients attended in Belém, Pará, Brazil

Revista Brasileira de Hematologia e Hemoterapia — Tue, 19 Apr 2011 17:41:19 +0100

CONCLUSION: These results show the importance of flow cytometry to identify cases in which patients are deficient in only one antigen (CD59). (Source: Revista Brasileira de Hematologia e Hemoterapia)

Cost of the treatment of myelodisplastic syndrome in Brazil

Revista Brasileira de Hematologia e Hemoterapia — Tue, 19 Apr 2011 17:41:19 +0100

CONCLUSION: In Brazil, treatment of low and intermediate I risk myelodysplastic syndrome is associated with a mean cost of the order of US$ 42,700/patient/year. New types of therapy have the potential to change this scenario if they can diminish the requirements for supportive care. (Source: Revista Brasileira de Hematologia e Hemoterapia)

Resting blood lactate in individuals with sickle cell disease

Revista Brasileira de Hematologia e Hemoterapia — Tue, 19 Apr 2011 17:41:19 +0100

BACKGROUND: The most common hereditary hemoglobin disorder, affecting 20 million individuals worldwide, is sickle cell disease. The vascular obstruction resulting from the sickling of cells in this disease can produce local hypoxemia, pain crises and infarction in several tissues, including the bones, spleen, kidneys and lungs. METHODS: The present study is characterized as a case control study, with the aim of identifying the baseline blood lactate concentration in individuals with hemoglobin SS and SC diseases. One-way ANOVA with the Tukey post-test was used to analyze the results and a p-value < 0.05 was considered significant. Calculations were made using the INSTAT statistical program. The graphs were generated using the ORING program. The study sample was composed of 31 men and women...

Genetic polymorphisms of Rh, Kell, Duffy and Kidd systems in a population from the State of Paraná, southern Brazil

Revista Brasileira de Hematologia e Hemoterapia — Tue, 19 Apr 2011 17:41:19 +0100

CONCLUSION: The RHCE*c/c, FY*A/FY*B, GATA-33 T/T, JK*B/JK*B genotypes were more prevalent in the population from Paraná, while RHCE*C/c, FY*B/FY*B, GATA-33 C/C, JK*A/JK*B genotypes were more common in the populations from São Paulo. (Source: Revista Brasileira de Hematologia e Hemoterapia)

Oral care in Brazilian bone marrow transplant centers

Revista Brasileira de Hematologia e Hemoterapia — Tue, 19 Apr 2011 17:41:19 +0100

CONCLUSION: Basic oral care constitutes regular assessment in the routine treatment of hematopoietic stem cell transplantation patients in Brazilian centers. (Source: Revista Brasileira de Hematologia e Hemoterapia)

Autologous hematopoietic stem cell transplantation in classical Hodgkin's lymphoma

Revista Brasileira de Hematologia e Hemoterapia — Tue, 19 Apr 2011 17:41:19 +0100

CONCLUSION: Autologous hematopoietic stem cell transplantation is an effective treatment strategy for early and late relapse in classical Hodgkin's lymphoma for cases that were responsive to pre-transplant chemotherapy. Refractory to treatment is a sign of worse prognosis. Additionally, a hemoglobin concentration below 10 g/dL at diagnosis of Hodgkin's lymphoma has a negative impact on the survival of patients after transplant. As far as we know this relationship has not been previously reported. (Source: Revista Brasileira de Hematologia e Hemoterapia)

Sickle cell disease: from the beginning until it was recognized as a public health disease

Revista Brasileira de Hematologia e Hemoterapia — Tue, 19 Apr 2011 17:41:19 +0100

(Source: Revista Brasileira de Hematologia e Hemoterapia)

Molecular polymorphisms of human blood groups: a universe to unravel

Revista Brasileira de Hematologia e Hemoterapia — Tue, 19 Apr 2011 17:41:19 +0100

(Source: Revista Brasileira de Hematologia e Hemoterapia)

Hematopoietic stem cell transplantation for Hodgkin's disease

Revista Brasileira de Hematologia e Hemoterapia — Tue, 19 Apr 2011 17:41:19 +0100

(Source: Revista Brasileira de Hematologia e Hemoterapia)

The AIBE and the new phase of the RBHH

Revista Brasileira de Hematologia e Hemoterapia — Tue, 19 Apr 2011 17:41:19 +0100

(Source: Revista Brasileira de Hematologia e Hemoterapia)

A new era, a new journal

Revista Brasileira de Hematologia e Hemoterapia — Tue, 19 Apr 2011 17:41:19 +0100

(Source: Revista Brasileira de Hematologia e Hemoterapia)

The evolution of the "Revista Brasileira de Hematologia e Hemoterapia" to meet the challenges of a new era

Revista Brasileira de Hematologia e Hemoterapia — Tue, 19 Apr 2011 17:41:19 +0100

(Source: Revista Brasileira de Hematologia e Hemoterapia)

The contribution of fortified foods in the prevention of iron deficiency anemia

Revista Brasileira de Hematologia e Hemoterapia — Fri, 08 Oct 2010 15:29:14 +0100

This article focuses on the contribution of fortified foods, developed from growing scientific knowledge, whose functions go beyond nutrition. Its main goal is to report on the physiological effects that improve health and wellness by correcting deficiencies inherent from the economic and social status of patients, pursuing practical conditions and respecting regional habits, in order to meet the needs of adequate micronutrient intake, in particular for locations where prevalence is high. Fortification should encompass all population segments, mainly in the pediatric phase, when needs are relatively high due to growth. The World Bank refers to the importance of food fortification as a strategy to fight against micronutrient deficiency throughout the world. It also claims that "no other tec...

The impact of food fortification on the prevention of iron deficiency

Revista Brasileira de Hematologia e Hemoterapia — Fri, 08 Oct 2010 15:29:14 +0100

Dentre as estratégias utilizadas para a prevenção da carência de micronutrientes, principalmente a anemia carencial ferropriva, considerada distúrbio nutricional de maior prevalência mundial, aponta-se a fortificação de alimentos como prioritária em termos de custo benefício. Vem sendo adotada nas últimas décadas em muitos países desenvolvidos e em desenvolvimento. Ressalta-se que a efetivação das medidas nesses países foram obtidas somente a partir de decisões políticas que culminaram no caráter compulsório da fortificação. Dessa forma, diversos alimentos têm sido utilizados para a fortificação, mostrando-se eficientes, bem aceitos e tolerados, não exigindo necessariamente a cooperação do beneficiário. A adição de nutrientes deve ocorrer em alimentos que efe...

The role of nurses in parenteral iron administration

Revista Brasileira de Hematologia e Hemoterapia — Fri, 08 Oct 2010 15:29:14 +0100

This article aims at describing nursing care with the intramuscular and intravenous administration of parenteral iron. The choice of the type of iron to be used depends on the tolerability of the patient. The intramuscular or intravenous administration of a medicine involves more than just the injection of a solution inside the muscle mass or vein, an evaluation of the best site for the injection must also be considered. This procedure must be carried out by a professional with knowledge on the basic aspects of administration, that is, the nursing team. It requires knowledge of the pharmacology of the drug type, mechanisms of action, excretion and performance in organic systems, as well as knowledge of the clinical evaluation of the patient's state of health. (Source: Revista Brasileira de...

Iron deficiency anemia treatment with parenteral iron

Revista Brasileira de Hematologia e Hemoterapia — Fri, 08 Oct 2010 15:29:14 +0100

Embora o ferro por via oral seja considerado a primeira opção de tratamento da deficiência de ferro, em algumas situações específicas, a administração de ferro por via parenteral é uma opção terapêutica que deve ser considerada. Diferentemente do ferro dextran de alto peso molecular utilizado na década de 80 e lembrado como um composto associado ao alto risco de reação anafilática e morte, o desenvolvimento e comercialização de novos compostos com ferro para uso parenteral, sobretudo por via endovenosa - como o ferro sacarato, ferro gluconato e, mais recentemente, a carboximaltose férrica - , tem se tornado cada vez mais uma alternativa terapêutica segura e efetiva, e tem possibilitado ampliar o leque de indicações desta modalidade de tratamento além da nefrologia, c...

Treatment of iron deficiency anemia with oral iron

Revista Brasileira de Hematologia e Hemoterapia — Fri, 08 Oct 2010 15:29:14 +0100

A anemia ferropriva permanece como uma das deficiências nutricionais mais frequentes e importantes no mundo. O tratamento com ferro deve ser iniciado preferencialmente por via oral e a investigação apropriada de sua causa é obrigatória. Os autores discutem os compostos com ferro atualmente disponíveis, o perfil de eficácia, segurança e tolerabilidade desses medicamentos, e o plano terapêutico mais adequado possível para o sucesso no tratamento dessa doença tão comum e importante.Iron deficiency anemia remains one of the commonest and most important nutritional deficiencies in the world today. The treatment of iron deficiency should preferably be initiated with oral iron; an appropriate investigation of the cause of iron deficiency anemia is mandatory. The authors discuss the cu...

Nutritional guidelines for patients with iron deficiency

Revista Brasileira de Hematologia e Hemoterapia — Fri, 08 Oct 2010 15:29:14 +0100

A deficiência de ferro ocorre quando as reservas nutricionais de ferro são esgotadas, principalmente devido ao balanço negativo entre ingestão e requerimentos de ferro. Quando a deficiência de ferro é severa desenvolve-se então a anemia por deficiência de ferro. A reposição dos estoques deve ser feita por meio de suplementação medicamentosa. A estratégia de educação nutricional, que visa o consumo quantitativo e qualitativo adequado de alimentos, fontes dos diversos nutrientes, é uma alternativa que possui baixo custo e não produz efeitos indesejáveis. O presente trabalho apresenta as recomendações nutricionais para a prevenção da deficiência de ferro e para o paciente com deficiência de ferro. A avaliação da ingestão alimentar e posterior orientação alimentar ...

Genetic causes for iron deficiency

Revista Brasileira de Hematologia e Hemoterapia — Fri, 08 Oct 2010 15:29:14 +0100

As causas genéticas de deficiência de ferro, real ou funcional, ocorrem por defeitos em muitas proteínas envolvidas na absorção e metabolismo de ferro. Neste capítulo descreveremos sucintamente causas genéticas de carência de ferro para a síntese de hemoglobina, que cursa então com anemia microcítica e hipocrômica. Ressalto que estas são alterações raras, com poucas descrições na literatura. Em alguns casos, o ferro funcional não está disponível para os eritroblastos sintetizarem hemoglobina, ou o eritroblasto é incapaz de captar ferro da circulação, mas o ferro está acumulado em tecidos ou nas mitocôndrias. Nos últimos anos, várias descobertas, principalmente oriundas de descrições em humanos ou de modelos animais, ajudaram a elucidar a implicação dos compon...

Iron deficiency in cancer patients

Revista Brasileira de Hematologia e Hemoterapia — Fri, 08 Oct 2010 15:29:14 +0100

O desenvolvimento de anemia é bastante frequente nos pacientes com câncer. Geralmente é decorrente de diversos fatores, sendo a deficiência de ferro um importante mecanismo. Ela pode ser absoluta, decorrente de perdas do estoque de ferro, ou funcional, devido à redução na absorção e disponibilização do ferro. Além de sintomas ligados à diminuição dos níveis de hemoglobina, como dispneia, palpitação e tonturas, a anemia impacta negativamente na sobrevida e acentua a fadiga relacionada ao câncer. Todos os pacientes com câncer e anemia devem ter seus parâmetros de ferro medidos e a investigação diagnóstica é guiada pelo tipo de tumor e sinais e sintomas do paciente. A deficiência funcional do ferro também está relacionada a menor resposta durante o tratamento com a...

Iron deficiency in heart failure patients

Revista Brasileira de Hematologia e Hemoterapia — Fri, 08 Oct 2010 15:29:14 +0100

A anemia é uma comorbidade frequente nos pacientes com insuficiência cardíaca (IC) e sua presença parece estar associada à pior evolução, sendo descrita em alguns estudos como fator de prognóstico independente tanto na IC sistólica quanto na diastólica. Entretanto, ainda não sabemos se a anemia causa pior evolução ou se é apenas um marcador do maior comprometimento cardíaco nos portadores de IC. A etiologia da anemia na IC é multifatorial e parece variar conforme a população estudada. Os fatores como a deficiência nutricional de ferro, presença de insuficiência renal, intensa atividade inflamatória sistêmica, uso de medicações que inibem a produção de eritropoetina ou que causam perda sanguínea são os mais frequentes causadores de anemia na IC. A prevalência d...

Iron deficiency in chronic kidney disease

Revista Brasileira de Hematologia e Hemoterapia — Fri, 08 Oct 2010 15:29:14 +0100

Anemia é uma complicação quase universal nos pacientes em estágios avançados de doença renal crônica (DRC). Ela está associada com maior número de internações hospitalares, maior mortalidade e pior qualidade de vida dos pacientes. Ela tem várias causas, sendo deficiência de eritropoetina e ferro as duas principais causas. A condição inflamatória presente na DRC interfere com a ação da eritropoetina e com a absorção intestinal de ferro e mobilização de ferro dos estoques, devido ao aumento de hepcidina. A correção parcial (não completa) da anemia promove melhores resultados nos pacientes com DRC.Anemia is an almost universal complication of patients in advanced stages of chronic kidney disease (CKD). It is associated with more hospitalizations, increased mortality a...

Iron deficiency anemia in patients submitted to gastric or small intestine resection: prevalence, cause, clinical outcome, diagnostic workup and prevention

Revista Brasileira de Hematologia e Hemoterapia — Fri, 08 Oct 2010 15:29:14 +0100

Anemia ferropriva é frequente em pacientes submetidos à ressecção gástrica, para o tratamento de úlcera péptica ou câncer gástrico, e à cirurgia bariátrica, para o tratamento de obesidade. As cirurgias bariátricas podem ter como consequência a restrição do estômago, sem necessariamente ressecção gástrica, ou ressecção gástrica associada ou não a ressecção intestinal. As causas da deficiência de ferro nestes pacientes são multifatoriais e incluem: (1) baixa ingestão de ferro oral por intolerância a alimentos ricos em ferro; (2) redução da acidez gástrica pela perda de células parietais, dificultando a conversão do ferro férrico para a forma ferrosa; (3) exclusão do duodeno com consequente exclusão do principal sítio de absorção do ferro e restrição ...

Iron deficiency related to gastrointestinal diseases in adults

Revista Brasileira de Hematologia e Hemoterapia — Fri, 08 Oct 2010 15:29:14 +0100

A anemia por deficiência de ferro (ADF) ou a deficiência de ferro (DF) isolada são comuns em crianças e mulheres pré-menopausa. Entretanto, em adultos do sexo masculino e mulheres pós-menopausa, essa condição se associa frequentemente a perdas sanguíneas gastrointestinais ou mal absorção. A prevalência das lesões gastrointestinais torna essencial o exame do aparelho digestório superior e inferior através da endoscopia. Investigações complementares devem ser realizadas se os procedimentos endoscópicos não evidenciarem sangramento em situações clínicas, tais como a necessidade de múltiplas hemotransfusões, a ausência de sangramento visível à endoscopia digestiva alta e colonoscopia e a falta de resposta à reposição de ferro.Esses casos devem ser direcionados par...

Iron deficiency and the intestinal tract in children

Revista Brasileira de Hematologia e Hemoterapia — Fri, 08 Oct 2010 15:29:14 +0100

A relação entre a deficiência de ferro, metabolismo do ferro e a função do intestino pode ser analisada sob várias perspectivas: intestino como sede da absorção do ferro regulada pela quantidade de ferro corporal através da hepcidina produzida no fígado, interação do ferro com outros nutrientes, repercussões da deficiência de ferro no intestino e o intestino como sede de perdas patológicas que podem causar ou agravar a deficiência de ferro. O objetivo deste artigo é abordar estes aspectos da interação entre o ferro e o intestino. Na deficiência de ferro observa-se aumento da absorção de ferro que, em animais, se acompanha de aumento da altura das vilosidades intestinais. Por outro lado, em humanos com anemia ferropriva pode ocorrer anormalidades da fisiologia intestin...

Iron deficiency in the elderly

Revista Brasileira de Hematologia e Hemoterapia — Fri, 08 Oct 2010 15:29:14 +0100

Anemia é comum em idosos e é associada a significante morbidade e mortalidade. Mais de 10% dos indivíduos acima de 65 anos tem anemia. Com uma proporção crescente da população mundial atingindo idade igual ou superior a 65 anos, a prevalência de anemia certamente aumentará no futuro. O diagnóstico precoce é importante para prevenir piora do quadro, diminuir progressão da doença e melhorar a evolução dos pacientes. Os critérios mais utilizados em estudos epidemiológicos para definir anemia em idosos são os da OMS (hemoglobina

The iron deficiency in pregnancy, labor and puerperium

Revista Brasileira de Hematologia e Hemoterapia — Fri, 08 Oct 2010 15:29:14 +0100

A anemia por deficiência de ferro representa desordem nutricional de maior prevalência em todo o mundo. As duas causas mais comuns de anemia na gestação e pós-parto são a deficiência de ferro e as perdas sanguíneas agudas. Na gestação, as mudanças fisiológicas podem dificultar o diagnóstico das doenças hematológicas. O propósito deste estudo é revisar a deficiência de ferro na gestação, as consequências adversas materno-fetais, o diagnóstico e manejo da anemia na gestação.Iron-deficiency anemia is a highly prevalent nutritional disorder in the whole world. The two most common causes of anemia in pregnancy and in the puerperium are iron deficiency and acute blood loss. Pregnancy is associated with physiological changes that may complicate the diagnosis of hematologic...

The iron deficiency in adult woman

Revista Brasileira de Hematologia e Hemoterapia — Fri, 08 Oct 2010 15:29:14 +0100

A anemia ferropriva é a doença nutricional de maior prevalência no mundo, atingindo 20% a 30% da população. As mulheres, gestantes ou não, fazem parte dos grupos considerados vulneráveis. Entre as possíveis causas da anemia por deficiência de ferro, as perdas sanguíneas menstruais constituem o principal fator de anemia ferropriva da mulher adulta. A proposta deste estudo é rever as causas da anemia na mulher adulta, principalmente decorrente de sangramentos uterinos, assim como o diagnóstico e adoção de medidas preventivas.Iron-deficiency anemia is the most common nutritional disease in the world, affecting from 20 to 30% of the population. Women, both pregnant and otherwise, are included as groups considered vulnerable. Among the possible causes of iron-deficiency anemia, me...

Iron deficiency in adolescence

Revista Brasileira de Hematologia e Hemoterapia — Fri, 08 Oct 2010 15:29:14 +0100

A deficiência de ferro é o distúrbio nutricional mais comum no mundo e constitui a maior causa de anemia associada às condições onde há erro alimentar, perda crônica de sangue ou quando ocorre o crescimento rápido, como na infância, na gravidez e na adolescência. Esta deficiência acarreta prejuízos no desenvolvimento neuropsicomotor, na capacidade de aprendizagem, no apetite, no crescimento e na resposta do sistema imunológico. Na adolescência, além de com frequência observarmos hábitos alimentares inadequados, estão presentes intensas mudanças fisiológicas e psicossociais que, em associação, podem comprometer o crescimento e aumentar o risco do desenvolvimento de deficiência de ferro e outras carências nutricionais, sobretudo na fase púbere. Desta forma, o diagn�...

Iron deficiency in infants and children

Revista Brasileira de Hematologia e Hemoterapia — Fri, 08 Oct 2010 15:29:14 +0100

Estima-se que dois bilhões de indivíduos sejam anêmicos e que a deficiência de ferro ocorra em cerca de quatro bilhões de indivíduos, afetando a população de países desenvolvidos e, com mais intensidade, a dos países em desenvolvimento. No Brasil, estudos apontam elevada prevalência de anemia ferropriva em crianças dependendo da região e da faixa etária. A velocidade de crescimento aumentada, determinando maior necessidade de ferro, aliada a dieta inadequada em ferro e ao desmame precoce, contribuem para a elevada prevalência de anemia, principalmente nos dois primeiros anos de vida. Outros fatores de risco são apontados, como a prematuridade, o baixo peso ao nascer, a ligadura precoce do cordão umbilical e o abandono do aleitamento materno exclusivo. O impacto da deficiê...

Iron deficiency in the fetus and newborn

Revista Brasileira de Hematologia e Hemoterapia — Fri, 08 Oct 2010 15:29:14 +0100

A principal causa de anemia no feto é a doença hemolítica do recém-nascido (RN). As gestantes anêmicas na sua forma moderada não acarretam baixos estoques de ferro no concepto, porém podem evoluir para o trabalho de parto prematuro e RN com baixo peso ao nascer. O ferro é transportado para o feto por via transplacentária, principalmente durante o terceiro trimestre de gestação. A deficiência de ferro não ocorre no período neonatal, porém os prematuros e ou RN com baixo peso constituem o principal grupo de risco para desenvolver a deficiência de ferro. Nos RN nascidos a termo podemos observar uma deficiência de ferro naqueles que sofreram ressecção cirúrgica do duodeno devido à malformação congênita. A fim de evitarmos a deficiência de ferro neste grupo de risco, in...

Differential diagnosis of iron deficiency

Revista Brasileira de Hematologia e Hemoterapia — Fri, 08 Oct 2010 15:29:14 +0100

This article briefly describes other conditions that may present with microcytic anemia such as thalassemia, anemia of chronic diseases, sideroblastic anemia and lead intoxication. These diseases should be considered during the investigation of iron deficiency anemia. (Source: Revista Brasileira de Hematologia e Hemoterapia)