MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Seminars in Diagnostic Pathology' source. Fri, 19 Mar 2010 16:10:05 +0100 http://www.medworm.com/index.php?rid=3249585&cid=s_38655_32_f&fid=38655&url=http%3A%2F%2Fwww.semdiagpath.com%2Farticle%2FPIIS0740257009000914%2Fabstract%3Frss%3Dyes Breast cancer is a heterogeneous disease and pathologists have evolved a system of classification that reflects this heterogeneity as well as provide prognostic and predictive information to manage patients. Professor Azzopardi's contribution to understanding and classifying breast disease is significant and reflected by the many articles in this issue. Nonetheless, there are limitations to the morphologic classification and new molecular methods promise to refine the biological understanding as well as provide better biomarkers for prognostication and targets for the development of novel therapeutics. The degree to which the new methods add value to the morphology remains to be seen, but there is hope that a symbiosis between morphology and molecular techniques will advance traditional hi... Seminars in Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=3249585 Mon, 01 Feb 2010 00:00:00 +0100 3249585 http://www.medworm.com/index.php?rid=3249584&cid=s_38655_32_f&fid=38655&url=http%3A%2F%2Fwww.semdiagpath.com%2Farticle%2FPIIS0740257009000975%2Fabstract%3Frss%3Dyes Salivary gland-type neoplasms of the breast are uncommon and comprise numerous entities analogous to that more commonly seen in salivary glands. The clinicopathologic spectrum ranges from benign to malignant but there are important differences as compared with those of their salivary counterpart. In the breast, benign adenomyoepithelioma is recognized in addition to malignant one, whereas in the salivary gland a histologically similar tumor is designated as epithelial-myoepithelial carcinoma without a separate benign subgroup. Mammary adenoid cystic carcinoma is a low-grade neoplasm compared with its salivary equivalent. It is also important to appreciate that in contrast to “triple negative” conventional breast carcinomas with aggressive course, most salivary-type malignant breast neo... Seminars in Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=3249584 Mon, 01 Feb 2010 00:00:00 +0100 3249584 http://www.medworm.com/index.php?rid=3249583&cid=s_38655_32_f&fid=38655&url=http%3A%2F%2Fwww.semdiagpath.com%2Farticle%2FPIIS0740257009000938%2Fabstract%3Frss%3Dyes Neuroendocrine breast carcinoma (NEBC) diagnosis relies on (i) presence of morphologic neuroendocrine features, and (ii) neuroendocrine markers expressed in more than 50% of tumor cells. The World Health Organization classification describes 3 main histologic types: the solid, the small/oat cell, and the large cell variant. In addition, we have recently proposed a further categorization into 5 subgroups: the first 3 categories encompass solid lesions and include (i) solid cohesive carcinomas, (ii) alveolar carcinomas, and (iii) small cell carcinoma; the last subgroups include mucin-producing tumors which are (iv) solid papillary carcinomas and (v) cellular mucinous carcinomas. Chromogranin A and synaptophysin have been considered as the most sensitive and specific neuroendocrine markers in... Seminars in Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=3249583 Mon, 01 Feb 2010 00:00:00 +0100 3249583 http://www.medworm.com/index.php?rid=3249582&cid=s_38655_32_f&fid=38655&url=http%3A%2F%2Fwww.semdiagpath.com%2Farticle%2FPIIS0740257009000926%2Fabstract%3Frss%3Dyes Assessing the distribution of the in situ and invasive components of breast carcinomas and the extent of the disease represent an integrated part of our diagnostic routine. In this article, we summarize findings from 792 consecutive breast carcinoma cases, each documented in large-format histology slides. Selected cases were also analyzed in thick, large sections. Of these, 35.0% (42/120) of the purely in situ carcinomas were diffuse and occupied mostly larger ducts, whereas 37.5% (45/120) were multifocal and involved several distant terminal ductal-lobular units (TDLUs). The proportion of unifocal in situ cases involving a single TDLU or several neighboring TDLUs was 27.5% (33/120). Forty-one percent (136/332) of early ( (Source: Seminars in Diagnostic Pathology) Seminars in Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=3249582 Mon, 01 Feb 2010 00:00:00 +0100 3249582 http://www.medworm.com/index.php?rid=3249581&cid=s_38655_32_f&fid=38655&url=http%3A%2F%2Fwww.semdiagpath.com%2Farticle%2FPIIS0740257009000999%2Fabstract%3Frss%3Dyes Lobular carcinoma is a special type of breast cancer that shows distinct clinical presentation, morphologic and molecular features, and clinical behavior, and its incidence is rising in recent years. Infiltrating lobular carcinoma (ILC) and its precursor lesions may result in diagnostic difficulties, particularly in the screening settings and their management may be problematic. Variants of lobular carcinoma, such as the pleomorphic variant, although not common, exist and some show differences in behavior warranting their recognition in view of requirements for different management strategies. Here we present a review of lobular carcinomas with particular attention to lobular in situ lesions, epidemiology, subtypes, diagnosis, molecular pathology, and grading of ILC in addition to the clin... Seminars in Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=3249581 Mon, 01 Feb 2010 00:00:00 +0100 3249581 http://www.medworm.com/index.php?rid=3249580&cid=s_38655_32_f&fid=38655&url=http%3A%2F%2Fwww.semdiagpath.com%2Farticle%2FPIIS0740257009000951%2Fabstract%3Frss%3Dyes Thirty years ago, John G. Azzopardi described a mainly cytologically defined atypical intraepithelial lesion of the breast, which he called “clinging carcinoma in situ,” a variant of “ductal carcinoma in situ.” The lesion was characterized by replacement of native epithelial cells by very few cell layers of mildly to severely atypical epithelial cells. Based on the degree of cytologic atypia, Azzopardi distinguished type 1 with highly atypical nuclei and type 2 with merely subtle cytologic (nuclear) atypia. Although this distinctive lesion remained widely unrecognized and/or ignored by many pathologists for a long period, several recent studies strongly suggest its neoplastic nature. The aim of this review is to focus on the “clinging” concept and its evolution after the first ... Seminars in Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=3249580 Mon, 01 Feb 2010 00:00:00 +0100 3249580 http://www.medworm.com/index.php?rid=3249579&cid=s_38655_32_f&fid=38655&url=http%3A%2F%2Fwww.semdiagpath.com%2Farticle%2FPIIS0740257009000963%2Fabstract%3Frss%3Dyes In 1979, Professor John Azzopardi introduced the term “clinging carcinoma” to describe what he considered to represent examples of ductal carcinoma in-situ (DCIS) characterized by “neoplastic cells…limited to the periphery of the containing structures.” He emphasized that these lesions can be easily missed “since the alteration is cytological rather than anatomical.” Two types of clinging carcinoma were described by Azzopardi. He considered the first to represent a variant of high-grade DCIS, and most pathologists concur with that view. In contrast, pathologists have been much more reluctant to accept Azzopardi's second type of clinging carcinoma as a type of DCIS, particularly in the United States. This second type is characterized by cells with low grade, monomorphic-type c... Seminars in Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=3249579 Mon, 01 Feb 2010 00:00:00 +0100 3249579 http://www.medworm.com/index.php?rid=3249578&cid=s_38655_32_f&fid=38655&url=http%3A%2F%2Fwww.semdiagpath.com%2Farticle%2FPIIS074025700900094X%2Fabstract%3Frss%3Dyes Papillomas and papillary carcinomas differ in their 3 fundamental characteristics: the geometric properties of their fronds, the amount of their stroma, and the characteristics of their epithelium. Fibrosis at the edge of papillomas often entraps glands and creates the spurious impression of invasion. The proliferation of surface epithelial cells of papillomas does not give rise to unexpected diagnostic difficulties, but glandular proliferation within the stalks of papillomas often simulates the appearance of cribriform ductal carcinoma in situ. Needle biopsies of papillomas can deposit clusters of benign cells in a distribution that resembles an invasive carcinoma. Although papillomas overrun by ductal carcinoma in situ exhibit a papillary architecture, other features differentiate them f... Seminars in Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=3249578 Mon, 01 Feb 2010 00:00:00 +0100 3249578 http://www.medworm.com/index.php?rid=3249577&cid=s_38655_32_f&fid=38655&url=http%3A%2F%2Fwww.semdiagpath.com%2Farticle%2FPIIS0740257009000987%2Fabstract%3Frss%3Dyes The lesion termed “infiltrating epitheliosis” (IE) by Azzopardi is described using his original criteria. The differential diagnosis from radial scar (RS) is discussed. It appears that IE and RS are histologically and histogenetically different and are also associated with a different risk of carcinoma. IE can be associated with either in situ or invasive carcinoma, whereas RS being more like a process of involution is very seldom involved by a carcinoma. Therefore, whatever name is used among the several found in the literature, it should be made clear they are not interchangeable when reporting on lesions like IE and RS. (Source: Seminars in Diagnostic Pathology) Seminars in Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=3249577 Mon, 01 Feb 2010 00:00:00 +0100 3249577 http://www.medworm.com/index.php?rid=3249576&cid=s_38655_32_f&fid=38655&url=http%3A%2F%2Fwww.semdiagpath.com%2Farticle%2FPIIS0740257009000902%2Fabstract%3Frss%3Dyes There are probably as many ways to perform surgical pathology as there are surgical pathologists in this world. However, if one looks carefully at the modus operandi and scientific production of the pre-eminent representatives of the specialty over the years, one begins to realize that they can be divided into 2 main models: the surgical pathologist–clinician (a primarily American phenomenon) and the surgical pathologist–morphologist–pathobiologist (a largely European species). The first type, represented by legendary people like Arthur Purdy Stout, Lauren Ackerman, Fred Stewart, Frank Foote, Malcolm Dockerty, and David Dahlin, involved professionals who were basically clinicians with a microscope. To be sure, they were also superb morphologists, with a legendary ability in the evalu... Seminars in Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=3249576 Mon, 01 Feb 2010 00:00:00 +0100 3249576 http://www.medworm.com/index.php?rid=3249575&cid=s_38655_32_f&fid=38655&url=http%3A%2F%2Fwww.semdiagpath.com%2Farticle%2FPIIS0740257009001002%2Fabstract%3Frss%3Dyes The year 2009 marks the 30th anniversary of the publication of Professor John G. Azzopardi's classical monograph, Problems in Breast Pathology. The community of breast pathologists felt that publishing a series of papers on selected topics in breast pathology to which Professor Azzopardi made significant contributions and about which he was passionate would be a fitting way to commemorate this occasion. The authors selected to write these papers have either worked directly with Professor Azzopardi or have for many years admired and have been influenced by his unique insights into various breast diseases. This issue of Seminars follows a meeting that was held in May 2006 in Malta, the native land of Professor Azzopardi, to honor him and to celebrate his accomplishments. (Source: Seminars in... Seminars in Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=3249575 Mon, 01 Feb 2010 00:00:00 +0100 3249575 http://www.medworm.com/index.php?rid=3249574&cid=s_38655_32_f&fid=38655&url=http%3A%2F%2Fwww.semdiagpath.com%2Farticle%2FPIIS0740257010000055%2Fabstract%3Frss%3Dyes (Source: Seminars in Diagnostic Pathology) Seminars in Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=3249574 Mon, 01 Feb 2010 00:00:00 +0100 3249574 http://www.medworm.com/index.php?rid=3249573&cid=s_38655_32_f&fid=38655&url=http%3A%2F%2Fwww.semdiagpath.com%2Farticle%2FPIIS0740257010000067%2Fabstract%3Frss%3Dyes (Source: Seminars in Diagnostic Pathology) Seminars in Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=3249573 Mon, 01 Feb 2010 00:00:00 +0100 3249573 http://www.medworm.com/index.php?rid=3249572&cid=s_38655_32_f&fid=38655&url=http%3A%2F%2Fwww.semdiagpath.com%2Farticle%2FPIIS0740257010000043%2Fabstract%3Frss%3Dyes (Source: Seminars in Diagnostic Pathology) Seminars in Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=3249572 Mon, 01 Feb 2010 00:00:00 +0100 3249572 http://www.medworm.com/index.php?rid=3249571&cid=s_38655_32_f&fid=38655&url=http%3A%2F%2Fwww.semdiagpath.com%2Farticle%2FPIIS0740257010000031%2Fabstract%3Frss%3Dyes (Source: Seminars in Diagnostic Pathology) Seminars in Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=3249571 Mon, 01 Feb 2010 00:00:00 +0100 3249571 http://www.medworm.com/index.php?rid=3249570&cid=s_38655_32_f&fid=38655&url=http%3A%2F%2Fwww.semdiagpath.com%2Farticle%2FPIIS074025701000002X%2Fabstract%3Frss%3Dyes (Source: Seminars in Diagnostic Pathology) Seminars in Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=3249570 Mon, 01 Feb 2010 00:00:00 +0100 3249570 http://www.medworm.com/index.php?rid=3037991&cid=s_38655_32_f&fid=38655&url=http%3A%2F%2Fwww.semdiagpath.com%2Farticle%2FPIIS0740257009000446%2Fabstract%3Frss%3Dyes The clinical reading environment for the twenty-first century pathologist looks very different than it did even a few short years ago. Glass slides are quickly being replaced by digital “virtual slides” and the traditional light microscope is being replaced by the computer display. There are numerous questions that arise however when deciding exactly what this new digital display viewing environment be like. Choosing a workstation for daily use in the interpretation of digital pathology images can be a very daunting task. Radiology went digital nearly 20 years ago and faced many of the same challenges so there are lessons to be learned from these experiences. One major lesson is that there is no “one size fits all” workstation so users must consider a variety of factors when choosi... Seminars in Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=3037991 Sun, 01 Nov 2009 00:00:00 +0100 3037991 http://www.medworm.com/index.php?rid=3037990&cid=s_38655_32_f&fid=38655&url=http%3A%2F%2Fwww.semdiagpath.com%2Farticle%2FPIIS074025700900046X%2Fabstract%3Frss%3Dyes Since mid-1996 we have operated a diagnostic robotic telepathology (TP) system at the Iron Mountain, Michigan, Department of Veterans Affairs Medical Center (VAMC) from the Milwaukee, Wisconsin VAMC, located some 220 miles away. No on-site pathologist is present in Iron Mountain. Instead, an experienced, well-trained pathologist assistant, under direction of pathologists located in Milwaukee, is responsible for tissue grossing and sectioning. The pathologist assistant places slides onto the stage of the robotic microscope, which is then controlled by pathologists in Milwaukee. Each case read by TP is subsequently read by light microscopy (LM) by the same pathologist. Three distinct phases of TP have been recognized. Our experience during Phase I (mid-1996 through early 1999) has been publi... Seminars in Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=3037990 Sun, 01 Nov 2009 00:00:00 +0100 3037990 http://www.medworm.com/index.php?rid=3037989&cid=s_38655_32_f&fid=38655&url=http%3A%2F%2Fwww.semdiagpath.com%2Farticle%2FPIIS0740257009000434%2Fabstract%3Frss%3Dyes An innovative telemedicine-enabled rapid breast care service is described that bundles telemammography, telepathology, and teleoncology services into a single day process. The service is called the UltraClinics® Process. Since the core services are at four different physical locations a challenge has been to obtain STAT second opinion readouts on newly diagnosed breast cancer cases. In order to provide same day QA re-review of breast surgical pathology cases, a DMetrix DX-40 ultrarapid virtual slide scanner (DMetrix, Inc., Tucson, AZ) was installed at the participating laboratory. Glass slides of breast cancer and breast hyperplasia cases were scanned the same day the slides were produced by the University Physicians Healthcare Hospital histology laboratory. Virtual slide telepathology wa... Seminars in Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=3037989 Sun, 01 Nov 2009 00:00:00 +0100 3037989 http://www.medworm.com/index.php?rid=3037988&cid=s_38655_32_f&fid=38655&url=http%3A%2F%2Fwww.semdiagpath.com%2Farticle%2FPIIS0740257009000458%2Fabstract%3Frss%3Dyes Although telepathology (TP) has not been widely implemented for primary frozen section diagnoses, interest in its use is growing as we move into an age of increasing sub-specialization and centralization of pathology services. University Health Network (UHN) is a 3-site academic institution in downtown Toronto. The pathology department is consolidated at its Toronto General Hospital (TGH) site. The Toronto Western Hospital (TWH), located 1 mile to west of TGH, has no on-site pathologist and generates 5-10 frozen section cases per week. Over 95% of these frozen sections are submitted by neurosurgeons, in most cases to confirm the presence of lesional tissue and establish a tissue diagnosis. In 2004, we implemented a robotic microscopy (RM) TP system to cover these frozen sections. In 2006, ... Seminars in Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=3037988 Sun, 01 Nov 2009 00:00:00 +0100 3037988 http://www.medworm.com/index.php?rid=3037987&cid=s_38655_32_f&fid=38655&url=http%3A%2F%2Fwww.semdiagpath.com%2Farticle%2FPIIS0740257009000707%2Fabstract%3Frss%3Dyes (Source: Seminars in Diagnostic Pathology) Seminars in Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=3037987 Sun, 01 Nov 2009 00:00:00 +0100 3037987 http://www.medworm.com/index.php?rid=3037986&cid=s_38655_32_f&fid=38655&url=http%3A%2F%2Fwww.semdiagpath.com%2Farticle%2FPIIS0740257009000719%2Fabstract%3Frss%3Dyes (Source: Seminars in Diagnostic Pathology) Seminars in Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=3037986 Sun, 01 Nov 2009 00:00:00 +0100 3037986 http://www.medworm.com/index.php?rid=3037985&cid=s_38655_32_f&fid=38655&url=http%3A%2F%2Fwww.semdiagpath.com%2Farticle%2FPIIS0740257009000690%2Fabstract%3Frss%3Dyes (Source: Seminars in Diagnostic Pathology) Seminars in Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=3037985 Sun, 01 Nov 2009 00:00:00 +0100 3037985 http://www.medworm.com/index.php?rid=3037984&cid=s_38655_32_f&fid=38655&url=http%3A%2F%2Fwww.semdiagpath.com%2Farticle%2FPIIS0740257009000689%2Fabstract%3Frss%3Dyes (Source: Seminars in Diagnostic Pathology) Seminars in Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=3037984 Sun, 01 Nov 2009 00:00:00 +0100 3037984 http://www.medworm.com/index.php?rid=3037983&cid=s_38655_32_f&fid=38655&url=http%3A%2F%2Fwww.semdiagpath.com%2Farticle%2FPIIS0740257009000677%2Fabstract%3Frss%3Dyes (Source: Seminars in Diagnostic Pathology) Seminars in Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=3037983 Sun, 01 Nov 2009 00:00:00 +0100 3037983 http://www.medworm.com/index.php?rid=2997898&cid=s_38655_32_f&fid=38655&url=http%3A%2F%2Fwww.semdiagpath.com%2Farticle%2FPIIS0740257009000422%2Fabstract%3Frss%3Dyes Keratoacanthomas are common self limited squamous proliferations. They have been considered a benign neoplasm with involution and complete resolution within few months. Although considered the prototypical example of cutaneous pseudomalignancy, some believe that these tumors are squamous cell carcinomas and through the years there have been sporadic reports of “metastasizing keratoacanthomas.” The question has been raised as to whether keratoacanthoma is an unreliable histological diagnosis or these tumors have a latent, albeit rare, malignant potential. To date, just a handful of “metastasizing keratoacanthomas” have been reported. Since a benign lesion is incapable of metastasis, some other explanation must be considered; the most likely one being a misdiagnosis. While it is clea... Seminars in Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2997898 Sat, 01 Aug 2009 00:00:00 +0100 2997898 http://www.medworm.com/index.php?rid=2997897&cid=s_38655_32_f&fid=38655&url=http%3A%2F%2Fwww.semdiagpath.com%2Farticle%2FPIIS0740257009000471%2Fabstract%3Frss%3Dyes Postradiation vascular tumors fall into two categories: (1) postradiation cutaneous angiosarcoma, malignant vascular neoplasms with significant morbidity and mortality; and (2) atypical vascular lesions (AVL), vascular tumors that reportedly behave in a benign manner. Postradiation vascular tumors not only present a therapeutic problem for clinicians, but they present an increasingly common diagnostic dilemma for pathologists. Although first described separately 15 years ago, the relationship between postradiation cutaneous angiosarcoma and AVL remains controversial. It appears that, in at least some cases, angiosarcoma can arise in the context of AVL, suggesting that these lesions are part of a spectrum of the same disease process. This latter view point is supported by the significant cl... Seminars in Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2997897 Sat, 01 Aug 2009 00:00:00 +0100 2997897 http://www.medworm.com/index.php?rid=2997896&cid=s_38655_32_f&fid=38655&url=http%3A%2F%2Fwww.semdiagpath.com%2Farticle%2FPIIS0740257009000203%2Fabstract%3Frss%3Dyes We elaborate on the diagnosis of CD30 positive cutaneous lymphoproliferative conditions including the various clinical and pathological presentations, our understanding of its pathomechanisms and prognostic implications. The most common reactive conditions that can simulate CD30 lymphoproliferative conditions, including arthropod bite reactions, various viral infections, pityriasis lichenoides and lymphocytic papules in myelodysplastic syndrome, are discussed in detail. (Source: Seminars in Diagnostic Pathology) Seminars in Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2997896 Sat, 01 Aug 2009 00:00:00 +0100 2997896 http://www.medworm.com/index.php?rid=2997895&cid=s_38655_32_f&fid=38655&url=http%3A%2F%2Fwww.semdiagpath.com%2Farticle%2FPIIS074025700900032X%2Fabstract%3Frss%3Dyes The connection between angiomyolipoma (AML) of the kidney, clear cell sugar tumor (CCST) of the lung, and pulmonary lymphangioleiomyoma (LAM), was progressively discovered because of the histologic and immunophenotypic similarities between the three tumors and their frequent association with tuberous sclerosis complex (TSC). Morphologically, analogous lesions found in other locations are composed of the unifying cell, the perivascular epithelioid cell (PEC). PEC tumors (or PEComas), other than AML, CCST, and LAM, are not associated with TSC and typically occur in middle-aged adult females. These neoplasms are composed of nests and fascicles of clear to granular epithelioid and/or spindled cells with a consistent arrangement around blood vessels. Characteristically, the cells express both m... Seminars in Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2997895 Sat, 01 Aug 2009 00:00:00 +0100 2997895 http://www.medworm.com/index.php?rid=2997894&cid=s_38655_32_f&fid=38655&url=http%3A%2F%2Fwww.semdiagpath.com%2Farticle%2FPIIS0740257009000513%2Fabstract%3Frss%3Dyes (Source: Seminars in Diagnostic Pathology) Seminars in Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2997894 Sat, 01 Aug 2009 00:00:00 +0100 2997894 http://www.medworm.com/index.php?rid=2997893&cid=s_38655_32_f&fid=38655&url=http%3A%2F%2Fwww.semdiagpath.com%2Farticle%2FPIIS0740257009000525%2Fabstract%3Frss%3Dyes (Source: Seminars in Diagnostic Pathology) Seminars in Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2997893 Sat, 01 Aug 2009 00:00:00 +0100 2997893 http://www.medworm.com/index.php?rid=2997892&cid=s_38655_32_f&fid=38655&url=http%3A%2F%2Fwww.semdiagpath.com%2Farticle%2FPIIS0740257009000501%2Fabstract%3Frss%3Dyes (Source: Seminars in Diagnostic Pathology) Seminars in Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2997892 Sat, 01 Aug 2009 00:00:00 +0100 2997892 http://www.medworm.com/index.php?rid=2997891&cid=s_38655_32_f&fid=38655&url=http%3A%2F%2Fwww.semdiagpath.com%2Farticle%2FPIIS0740257009000495%2Fabstract%3Frss%3Dyes (Source: Seminars in Diagnostic Pathology) Seminars in Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2997891 Sat, 01 Aug 2009 00:00:00 +0100 2997891 http://www.medworm.com/index.php?rid=2997890&cid=s_38655_32_f&fid=38655&url=http%3A%2F%2Fwww.semdiagpath.com%2Farticle%2FPIIS0740257009000483%2Fabstract%3Frss%3Dyes (Source: Seminars in Diagnostic Pathology) Seminars in Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2997890 Sat, 01 Aug 2009 00:00:00 +0100 2997890 http://www.medworm.com/index.php?rid=2860734&cid=s_38655_32_f&fid=38655&url=http%3A%2F%2Fwww.semdiagpath.com%2Farticle%2FPIIS0740257009000197%2Fabstract%3Frss%3Dyes Secondary vasculopathies have varied etiologies that include paraneoplastic processes (eg, migratory thrombophlebitis, urticarial vasculitis); direct invasion by tumors (eg, superior and inferior vena cava syndrome); metabolic diseases (eg, diabetes mellitus); and infections, among others. The infective causes of vasculitides could result from direct involvement of vessels by a vasculo-tropic agent (eg, mucor infection); adjacent inflammation nonspecifically affecting nearby vessels; or from infection-induced immune-mediated vasculitis. Viruses represent a major group in the development of the latter, and many human viruses have been reported to cause vasculitis. The vasculitic lesions secondary to hepatitis B and hepatitis C viruses largely fall within the spectrum of immune-mediated seco... Seminars in Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2860734 Thu, 30 Apr 2009 23:00:00 +0100 2860734 http://www.medworm.com/index.php?rid=2860733&cid=s_38655_32_f&fid=38655&url=http%3A%2F%2Fwww.semdiagpath.com%2Farticle%2FPIIS0740257009000185%2Fabstract%3Frss%3Dyes Cerebrovascular disease (CVD) is one of the commonest causes of disability and mortality worldwide. It includes all disorders in which an area of the brain is transiently or permanently affected by ischemia or bleeding. In this review, we describe the neuropathological changes associated with the most common entities leading to brain ischemia and hemorrhage. (Source: Seminars in Diagnostic Pathology) Seminars in Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2860733 Thu, 30 Apr 2009 23:00:00 +0100 2860733 http://www.medworm.com/index.php?rid=2860732&cid=s_38655_32_f&fid=38655&url=http%3A%2F%2Fwww.semdiagpath.com%2Farticle%2FPIIS0740257009000173%2Fabstract%3Frss%3Dyes Vasculitis refers to vessel wall leukocyte infiltration, often with necrosis, and can involve any of one or more vessels in the body. The kidney is commonly affected by vasculitis. Vasculitis is best classified based on the size of the involved vessels into large, medium, and small vessel disease. Small vessel vasculitis (SVV) that includes glomerulonephritis is by far the most frequent vasculitic lesion in the kidney, and the defining renal lesion is a necrotizing crescentic glomerulonephritis. Medium vessel vasculitis occasionally involves the kidney as necrotizing arteritis, and large vessel vasculitis only rarely affects the kidney, and most often secondarily by ischemia from proximal arterial narrowing. In this review, we describe the clinical and pathologic features of the various va... Seminars in Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2860732 Thu, 30 Apr 2009 23:00:00 +0100 2860732 http://www.medworm.com/index.php?rid=2860731&cid=s_38655_32_f&fid=38655&url=http%3A%2F%2Fwww.semdiagpath.com%2Farticle%2FPIIS0740257009000161%2Fabstract%3Frss%3Dyes Systemic vasculitis is often not considered as a possible diagnosis by clinicians because of its low prevalence compared with other more common diseases. Vasculitis can affect any end organ, and it is therefore often missed early on in disease progression. Gastrointestinal (GI) manifestations of vasculitis are considered rare and the presentation is often nonspecific. However, if there is significant involvement of the major vessels of the gastrointestinal system, life-threatening sequelae, including perforation and bowel ischemia, may occur. This makes early and immediate management crucial to improve long-term morbidity and mortality. Diagnosis of various GI vasculitides often relies on correlation of clinical manifestations with pathology and additional investigations. This paper review... Seminars in Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2860731 Thu, 30 Apr 2009 23:00:00 +0100 2860731 http://www.medworm.com/index.php?rid=2860730&cid=s_38655_32_f&fid=38655&url=http%3A%2F%2Fwww.semdiagpath.com%2Farticle%2FPIIS0740257009000240%2Fabstract%3Frss%3Dyes (Source: Seminars in Diagnostic Pathology) Seminars in Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2860730 Thu, 30 Apr 2009 23:00:00 +0100 2860730 http://www.medworm.com/index.php?rid=2860729&cid=s_38655_32_f&fid=38655&url=http%3A%2F%2Fwww.semdiagpath.com%2Farticle%2FPIIS0740257009000252%2Fabstract%3Frss%3Dyes (Source: Seminars in Diagnostic Pathology) Seminars in Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2860729 Thu, 30 Apr 2009 23:00:00 +0100 2860729 http://www.medworm.com/index.php?rid=2860728&cid=s_38655_32_f&fid=38655&url=http%3A%2F%2Fwww.semdiagpath.com%2Farticle%2FPIIS0740257009000239%2Fabstract%3Frss%3Dyes (Source: Seminars in Diagnostic Pathology) Seminars in Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2860728 Thu, 30 Apr 2009 23:00:00 +0100 2860728 http://www.medworm.com/index.php?rid=2860727&cid=s_38655_32_f&fid=38655&url=http%3A%2F%2Fwww.semdiagpath.com%2Farticle%2FPIIS0740257009000227%2Fabstract%3Frss%3Dyes (Source: Seminars in Diagnostic Pathology) Seminars in Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2860727 Thu, 30 Apr 2009 23:00:00 +0100 2860727 http://www.medworm.com/index.php?rid=2860726&cid=s_38655_32_f&fid=38655&url=http%3A%2F%2Fwww.semdiagpath.com%2Farticle%2FPIIS0740257009000215%2Fabstract%3Frss%3Dyes (Source: Seminars in Diagnostic Pathology) Seminars in Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2860726 Thu, 30 Apr 2009 23:00:00 +0100 2860726 http://www.medworm.com/index.php?rid=2481619&cid=s_38655_32_f&fid=38655&url=http%3A%2F%2Fwww.semdiagpath.com%2Farticle%2FPIIS0740257008001184%2Fabstract%3Frss%3Dyes The following is a list of 68 questions formulated as a member benefit for the American Academy of Clinical Toxicology (AACT). One question/answer is e-mailed daily to members under the title “AACT Tox Question of the Day.” Each answer is appropriately referenced. As the reader can see from the scope of these questions, the field of Clinical Toxicology is extremely diverse and encompasses virtually every medical specialty. (Source: Seminars in Diagnostic Pathology) Seminars in Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2481619 Sun, 01 Feb 2009 05:00:00 +0100 2481619 http://www.medworm.com/index.php?rid=2481618&cid=s_38655_32_f&fid=38655&url=http%3A%2F%2Fwww.semdiagpath.com%2Farticle%2FPIIS0740257008001147%2Fabstract%3Frss%3Dyes The medical response to radiation—whether the result of radiological warfare, terrorist deployment of improvised radiation dispersal weapons, political assassination, occupational or industrial accidents or the medically radiated patient remains one of the least taught among all disciplines within medical education. In the aftermath of 9/11 among medical vulnerabilities to toxicant threats, of all the categories of weapons of mass destruction (WMD)—whether using the CBRNE (chemical, biological, radiological, nuclear, explosive) or NBC (nuclear, biological, chemical) acronym—radiation is the least taught in professional schools, responder cultures or civil preparedness organizations. To date, few health care professionals (HCP) possess the fundamental knowledge or skills to identify a... Seminars in Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2481618 Sun, 01 Feb 2009 05:00:00 +0100 2481618 http://www.medworm.com/index.php?rid=2481617&cid=s_38655_32_f&fid=38655&url=http%3A%2F%2Fwww.semdiagpath.com%2Farticle%2FPIIS0740257008001202%2Fabstract%3Frss%3Dyes Conclusion: If geographical values are obtained in a certain area, the normal reference value of red blood cell count of young men in this area can be reckoned by using the regression equation. Furthermore, according to the geographical factors, China can be divided into eight districts: Northeast China District, North China District, Shanxi-Shaanxi-Inner Mongolia District, Middle and Lower reaches of the Changjiang River District, Southeast China District, Northwest China District, Southwest China District, and Qinghai-Tibet Plateau District. (Source: Seminars in Diagnostic Pathology) Seminars in Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2481617 Sun, 01 Feb 2009 05:00:00 +0100 2481617 http://www.medworm.com/index.php?rid=2481616&cid=s_38655_32_f&fid=38655&url=http%3A%2F%2Fwww.semdiagpath.com%2Farticle%2FPIIS0740257008001196%2Fabstract%3Frss%3Dyes This article briefly discusses acute cyanide poisoning and treatment, and summarizes laboratory interferences that have been reported with the use of hydroxocobalamin. (Source: Seminars in Diagnostic Pathology) Seminars in Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2481616 Sun, 01 Feb 2009 05:00:00 +0100 2481616 http://www.medworm.com/index.php?rid=2481615&cid=s_38655_32_f&fid=38655&url=http%3A%2F%2Fwww.semdiagpath.com%2Farticle%2FPIIS0740257008001135%2Fabstract%3Frss%3Dyes A multi-billion dollar industry has evolved over the last decade based on herbal product sales with an underlying belief that herbals are natural and therefore safe. The herbal product industry is essentially unregulated and producers are not required to follow good manufacturing practices (GMP). Batch to batch product variation, heavy metal and pesticide contamination, and even therapeutic drug contamination are problematic. Compounding these manufacturing issues are drug to drug and drug to herbal interactions that can cause cytochrome induction or inhibition. It is important for physicians to query their patients on herbal use and educate them on the potential adverse reactions. Herbals have been used for thousands of years and undoubtedly have demonstrated health benefits. However, mor... Seminars in Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2481615 Sun, 01 Feb 2009 05:00:00 +0100 2481615 http://www.medworm.com/index.php?rid=2481614&cid=s_38655_32_f&fid=38655&url=http%3A%2F%2Fwww.semdiagpath.com%2Farticle%2FPIIS0740257008001159%2Fabstract%3Frss%3Dyes This article is a review of the history and current status of herbs in the United States. The clinical effects of herbs and herbal medicine will be reviewed with respect to side effects and clinical toxicity. Treatment of herbal toxicity will be described where indicated. (Source: Seminars in Diagnostic Pathology) Seminars in Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2481614 Sun, 01 Feb 2009 05:00:00 +0100 2481614 http://www.medworm.com/index.php?rid=2481613&cid=s_38655_32_f&fid=38655&url=http%3A%2F%2Fwww.semdiagpath.com%2Farticle%2FPIIS0740257008001160%2Fabstract%3Frss%3Dyes Ethyl glucuronide (EtG) is a direct phase-II metabolite of ethanol formed through the UDP-glucuronosyl transferase catalyzed conjugation of ethanol with glucuronic acid. It has been detected in many antemortem and postmortem biological matrices using a variety of analytical methods. Due to its long urinary elimination time, detectability in hair, specificity for ethanol exposure, and low detection limits of assays, the use of EtG has been proposed as a marker of recent ethanol intake in a variety of clinical and legal settings, including medical monitoring for relapse, emergency department patient evaluation, postmortem assessments, and transportation accident investigation. However, challenges associated with factors such as establishing appropriate cut-off levels capable of distinguishin... Seminars in Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2481613 Sun, 01 Feb 2009 05:00:00 +0100 2481613 http://www.medworm.com/index.php?rid=2481612&cid=s_38655_32_f&fid=38655&url=http%3A%2F%2Fwww.semdiagpath.com%2Farticle%2FPIIS0740257008001123%2Fabstract%3Frss%3Dyes This article describes the history and pharmacology of illicit cocaine use. (Source: Seminars in Diagnostic Pathology) Seminars in Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2481612 Sun, 01 Feb 2009 05:00:00 +0100 2481612 http://www.medworm.com/index.php?rid=2481611&cid=s_38655_32_f&fid=38655&url=http%3A%2F%2Fwww.semdiagpath.com%2Farticle%2FPIIS0740257008001214%2Fabstract%3Frss%3Dyes Severe hepatotoxicity in acute acetaminophen overdose in children is uncommon. This apparent protection does not extend to chronic or repeated high dose acetaminophen administration. The Illinois Poison Center (IPC) was consulted on a case involving a 7 month old 17 lb infant, who had presented the day prior to an emergency department with complaint of febrile illness. Patient had been prescribed acetaminophen for symptoms, and the mother called IPC when she realized that she had been incorrectly giving the patient concentrated infant acetaminophen (80 mg per 0.8 mL) totalling 42.3 mg/kg/dose or 234 mg/kg/24 hours instead of children's acetaminophen (160 mg/5 ml). Per recently published national triage guidelines, the patient was referred to an acute care facility for evaluation. The patie... Seminars in Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2481611 Sun, 01 Feb 2009 05:00:00 +0100 2481611 http://www.medworm.com/index.php?rid=2481610&cid=s_38655_32_f&fid=38655&url=http%3A%2F%2Fwww.semdiagpath.com%2Farticle%2FPIIS0740257008001172%2Fabstract%3Frss%3Dyes Poor communication between the clinical toxicologist and the toxicology laboratory can result in a variety of problems. Clinicians must familiarize themselves with the toxicology assays that are available in their hospital and how to interpret assay results. Toxicology tests ordered in the emergency department should provide useful information for patient management and disposition. Toxicology laboratory personnel should have a good working relationship with emergency department clinicians and clinical toxicologists to maximize the usefulness of the laboratory in patient management. (Source: Seminars in Diagnostic Pathology) Seminars in Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2481610 Sun, 01 Feb 2009 05:00:00 +0100 2481610 http://www.medworm.com/index.php?rid=2481609&cid=s_38655_32_f&fid=38655&url=http%3A%2F%2Fwww.semdiagpath.com%2Farticle%2FPIIS0740257009000021%2Fabstract%3Frss%3Dyes The field of medical toxicology is a widely diverse field in which the clinical laboratory plays an integral role. The term “toxicology” can be thought of as the assault, absorption and adverse effects of foreign substances to the human body. In this way, the areas of drug overdose, drug interactions, allergic reactions, illicit drug abuse, hazardous chemical exposures, radiation, psychiatry, wilderness/environmental medicine, infectious agents, food safety, botany, virology, zoology, parasitology, mycology, teratology and of course, pharmacology. The articles in this special toxicology/environmental medicine issue of Seminars in Diagnostic Pathology reflect this diverse field. Dr. Kantor's article focuses on the interaction of the hospital-based laboratory and the clinical toxicologis... Seminars in Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2481609 Sun, 01 Feb 2009 05:00:00 +0100 2481609 http://www.medworm.com/index.php?rid=2481608&cid=s_38655_32_f&fid=38655&url=http%3A%2F%2Fwww.semdiagpath.com%2Farticle%2FPIIS0740257009000069%2Fabstract%3Frss%3Dyes (Source: Seminars in Diagnostic Pathology) Seminars in Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2481608 Sun, 01 Feb 2009 05:00:00 +0100 2481608 http://www.medworm.com/index.php?rid=2481607&cid=s_38655_32_f&fid=38655&url=http%3A%2F%2Fwww.semdiagpath.com%2Farticle%2FPIIS0740257009000070%2Fabstract%3Frss%3Dyes (Source: Seminars in Diagnostic Pathology) Seminars in Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2481607 Sun, 01 Feb 2009 05:00:00 +0100 2481607 http://www.medworm.com/index.php?rid=2481606&cid=s_38655_32_f&fid=38655&url=http%3A%2F%2Fwww.semdiagpath.com%2Farticle%2FPIIS0740257009000057%2Fabstract%3Frss%3Dyes (Source: Seminars in Diagnostic Pathology) Seminars in Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2481606 Sun, 01 Feb 2009 05:00:00 +0100 2481606 http://www.medworm.com/index.php?rid=2481605&cid=s_38655_32_f&fid=38655&url=http%3A%2F%2Fwww.semdiagpath.com%2Farticle%2FPIIS0740257009000045%2Fabstract%3Frss%3Dyes (Source: Seminars in Diagnostic Pathology) Seminars in Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2481605 Sun, 01 Feb 2009 05:00:00 +0100 2481605 http://www.medworm.com/index.php?rid=2481604&cid=s_38655_32_f&fid=38655&url=http%3A%2F%2Fwww.semdiagpath.com%2Farticle%2FPIIS0740257009000033%2Fabstract%3Frss%3Dyes (Source: Seminars in Diagnostic Pathology) Seminars in Diagnostic Pathology journals http://www.medworm.com/rss/comments.php?id=2481604 Sun, 01 Feb 2009 05:00:00 +0100 2481604