MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Skin Therapy Letter' source. Tue, 02 Mar 2010 14:15:10 +0100 http://www.medworm.com/index.php?rid=3166182&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20066388%26dopt%3DAbstract Authors: Moody MN, Morrison LK, Tyring SK In atopic dermatitis (AD), the stratum corneum of patients appears to have alterations that predispose them to colonization and invasion by various bacteria, most notably Staphylococcus aureus (S. aureus). This bacterial co-existence is accepted to be an important factor in AD disease activity. Exactly when to initiate antimicrobial treatment is controversial, but such intervention, when warranted, has repeatedly been demonstrated to improve the course of AD. However, the increase in antibiotic resistance presents a therapeutic challenge in the management of AD patients, which highlights the need for novel mechanism topical antibacterial agents. Retapamulin is a relatively new pleuromutilin antibiotic designed for topical use. In vitro studies ... Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=3166182 Fri, 01 Jan 2010 00:00:00 +0100 3166182 http://www.medworm.com/index.php?rid=3166181&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20066389%26dopt%3DAbstract Authors: Lynde CW, Sapra S Genetic predisposition to melanoma and nonmelanoma skin cancer extends far beyond the Fitzpatrick phenotype classification scheme. Specific alleles of the gene that codes for the malnocortin 1 receptor are predictive of skin cancer risk independent of skin type and hair color. The ability to identify high risk patients independent of the red hair phenotype may help to modify routine sun and skin monitoring behaviors. In addition, as this increased skin cancer risk is likely due to impaired UVA and UVB defence mechanisms, consideration of genetic predisposition may also be appropriate for patients undergoing psoralen + UVA (PUVA) or UVB treatments for various cutaneous disorders, such as psoriasis, eczema, and vitiligo. Testing aimed at improving prognosticati... Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=3166181 Fri, 01 Jan 2010 00:00:00 +0100 3166181 http://www.medworm.com/index.php?rid=3156814&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20054504%26dopt%3DAbstract Authors: Pierre SA, Bartlett BL, Schlosser BJ Recurrent herpes labialis (RHL) is a common condition associated with the formation of vesicles around the mouth, often preceded by prodromal symptoms including tingling and burning. Treatment is targeted toward individual episodes, but in severe cases, suppressive therapy may be indicated. At present, no cure exists for this troublesome condition. The purpose of this article is to serve as a practical guide in the management of RHL by summarizing current treatments and discussing potential new therapies. PMID: 20054504 [PubMed - in process] (Source: Skin Therapy Letter) Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=3156814 Sun, 01 Nov 2009 00:00:00 +0100 3156814 http://www.medworm.com/index.php?rid=3156813&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20054505%26dopt%3DAbstract Authors: Langan SM Eczema is a major public health problem affecting children worldwide. Few studies have directly assessed triggers for disease flares. This paper presents evidence from a published systematic review and a prospective cohort study looking at flare factors in eczema. This systematic review suggested that foodstuffs in selected groups, dust exposure, unfamiliar pets, seasonal variation, stress, and irritants may be important in eczema flares. We performed a prospective cohort study that focused on environmental factors and identified associations between exposure to nylon clothing, dust, unfamiliar pets, sweating, shampoo, and eczema flares. Results from this study also demonstrated some new key findings. First, the effect of shampoo was found to increase in cold weather... Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=3156813 Sun, 01 Nov 2009 00:00:00 +0100 3156813 http://www.medworm.com/index.php?rid=3133149&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20039595%26dopt%3DAbstract Authors: Alsantali A, Shapiro J Hirsutism is a relatively common condition affecting about 5%-O10% of women of childbearing age. Herein, we present an overview of hirsutism with emphasis on its etiology and therapeutic options. PMID: 20039595 [PubMed - in process] (Source: Skin Therapy Letter) Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=3133149 Tue, 01 Sep 2009 00:00:00 +0100 3133149 http://www.medworm.com/index.php?rid=3133148&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20039596%26dopt%3DAbstract Authors: Hogan L, Armstrong ML Young adult populations (18-25 years of age) throughout the world have latched onto the mainstream trend of body piercing. Best health care practices for these individuals involves the knowledge of proper procedural techniques, postsite care, common complications, and treatment modalities. PMID: 20039596 [PubMed - in process] (Source: Skin Therapy Letter) Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=3133148 Tue, 01 Sep 2009 00:00:00 +0100 3133148 http://www.medworm.com/index.php?rid=2615790&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19609473%26dopt%3DAbstract Authors: Ortiz-Policarpio B, Lui H Methyl aminolevulinate-hydrochloride cream (Metvix(R) [in Canada] and Metvixia(R) [in the US], Galderma) in combination with photodynamic therapy (PDT) provides an effective treatment option for actinic keratoses (AKs), superficial basal cell carcinoma (sBCC), and Bowen's disease (BD). Good clinical outcomes have been reported in the literature. Complete responses (CRs) in AK range from 69% to 93% at 3 months. In sBCC, reported CR rates were from 85% to 93% at 3 months and almost on par with cryosurgery at 60 months (75% vs. 74%). In BD, CR rates were 93% at 3 months and 68% at 2 years. Current evidence has shown that this noninvasive treatment is superior in terms of cosmetic outcome to other management strategies such as surgery. It also offers the ... Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=2615790 Tue, 30 Jun 2009 23:00:00 +0100 2615790 http://www.medworm.com/index.php?rid=2615789&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19609474%26dopt%3DAbstract Authors: Tan JK Topical products commonly used to treat acne include retinoids and antimicrobials, due to their effects on different components of pathogenesis. Accordingly, a fixed combination of adapalene 0.1% and benzoyl peroxide (BPO) 2.5% was developed (EpiduoTM, Galderma) and was approved by the US FDA in December 2008 for the treatment of acne. The superior efficacy of this combination was demonstrated in 2 large randomized controlled trials. This paper reviews the evidence for efficacy and tolerability of the combination of the retinoid adapalene 0.1% and BPO 2.5%, a once-daily gel formulation for the treatment of acne. PMID: 19609474 [PubMed - in process] (Source: Skin Therapy Letter) Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=2615789 Tue, 30 Jun 2009 23:00:00 +0100 2615789 http://www.medworm.com/index.php?rid=2615792&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19609471%26dopt%3DAbstract Safety, Efficacy & Recurrence Rates of Imiquimod Cream 5% for Treatment of Anogenital Warts. Skin Therapy Lett. 2009 Jun;14(5):1-3 Authors: Diamantis ML, Bartlett BL, Tyring SK Imiquimod 5% cream (AldaraTM, Graceway Pharmaceuticals) is an immune response modifier used for the topical treatment of anogenital warts in non-HIV-infected patients. Several randomized controlled trials have demonstrated that imiquimod 5% cream is a safe and efficacious treatment. Current data regarding efficacy shows that complete clearance of warts occurred in up to 50% of patients treated with imiquimod 5% cream applied once-daily, 3 times per week for up to 16 weeks. Recurrence rates ranged from up to 19% at 3 months to 23% at 6 months. Imiquimod 5% cream showed an acceptable safety profile; lo... Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=2615792 Sun, 31 May 2009 23:00:00 +0100 2615792 http://www.medworm.com/index.php?rid=2615791&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19609472%26dopt%3DAbstract Authors: Schroeder P, Calles C, Krutmann J Photoaging and skin damage that is caused by solar radiation is well known. We have recently learned that within the solar spectrum this damage not only results from ultraviolet (UV) radiation, but also from longer wavelengths, in particular near infrared radiation. Accordingly, infrared radiation (IR) has been shown to alter the collagen equilibrium of the dermal extracellular matrix in at least 2 ways: (1) by leading to an increased expression of the collagen degrading enzyme matrixmetalloproteinase-1 while (2) decreasing the de novo synthesis of the collagen itself. Infrared-A (IRA) radiation exposure, therefore, induces similar biological effects to UV, but the underlying mechanisms are substantially different. IRA acts via the mitochondri... Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=2615791 Sun, 31 May 2009 23:00:00 +0100 2615791 http://www.medworm.com/index.php?rid=2588992&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19585059%26dopt%3DAbstract Authors: Guenther LC Scalp psoriasis occurs in 50%-75% of patients with plaque psoriasis. It may be the only area of the body affected, or it may be associated with disease elsewhere, including psoriatic arthritis. Most cases are treated topically, usually with steroids and/or calcipotriol. In 2008, Health Canada and the US FDA approved a stable, once-daily 2-compound gel containing calcipotriol and betamethasone dipropionate (Xamiol(R), LEO Pharma; Taclonex Scalp(R), Warner Chilcott). This once-daily therapy improves patient quality of life with a quick onset of action and greater efficacy than monotherapy with either ingredient or twice daily treatment with calcipotriol 0.005% (Dovonex(R), LEO Pharma) scalp solution. The gel vehicle was developed for ease of use, improved cosmetic ac... Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=2588992 Thu, 30 Apr 2009 23:00:00 +0100 2588992 http://www.medworm.com/index.php?rid=2588991&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19585060%26dopt%3DAbstract Authors: Berti S, Buggiani G, Lotti T Current treatments for vitiligo are largely unsatisfactory. Topical corticosteroids and phototherapy (narrow-band UVB and psoralen+UVA) are the most prescribed, however, these therapies are often not effective and have important side-effect, especially when used for a long time. Many studies have reported the efficacy and safety of tacrolimus ointment in adults and children with vitiligo, particularly when located on the head and neck. Successful treatment is possible when it is combined with other therapies, such as narrow-band UVB, microphototherapy, helium-neon laser, or narrow-band excimer laser. PMID: 19585060 [PubMed - in process] (Source: Skin Therapy Letter) Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=2588991 Thu, 30 Apr 2009 23:00:00 +0100 2588991 http://www.medworm.com/index.php?rid=2588994&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19585057%26dopt%3DAbstract This article will review the new and existing treatments that are available for this common dermatologic problem. PMID: 19585057 [PubMed - in process] (Source: Skin Therapy Letter) Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=2588994 Sun, 01 Mar 2009 00:00:00 +0100 2588994 http://www.medworm.com/index.php?rid=2588993&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19585058%26dopt%3DAbstract Authors: Drago F, Rebora A Pityriasis rosea is a common skin disorder in children and young adults. It is a self-limiting disease with symptoms that are typically mild and tolerable. Consequently, the best treatment remains the one followed so far by generations of dermatologists: reassuring the patient and letting the condition go away on its own. However, there are times when treatment is recommended. In this paper, we review the available treatments for this skin disease. PMID: 19585058 [PubMed - in process] (Source: Skin Therapy Letter) Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=2588993 Sun, 01 Mar 2009 00:00:00 +0100 2588993 http://www.medworm.com/index.php?rid=2306923&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19330270%26dopt%3DAbstract Authors: Gooderham M Many options exist for the treatment of rosacea, including topical and systemic therapies, laser and light-based therapies, and surgical procedures. A classification system for rosacea identifies 4 subtypes (i.e., erythematotelangiectatic, papulopustular, phymatous, and ocular), which may help guide therapeutic decision-making. The goals of therapy include reduction of papules, pustules, erythema, physical discomfort, and an improvement in quality of life. Standard topical treatment agents include metronidazole, azelaic acid, and sodium sulfacetamide-sulfur. Second line therapies include benzoyl peroxide, clindamycin, calcineurin inhibitors, and permethrin. PMID: 19330270 [PubMed - in process] (Source: Skin Therapy Letter) Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=2306923 Sun, 01 Feb 2009 05:00:00 +0100 2306923 http://www.medworm.com/index.php?rid=2186531&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19214354%26dopt%3DAbstract Authors: Barber K, Barber J Onychomycosis is one of the most common nail disorders. Despite recent therapeutic advances with the introduction of effective systemic agents and transungual drug delivery systems, the incidence of onychomycosis is increasing. This is of concern, as the morbidity related to this infection also increases as our population ages with associated conditions, such as diabetes and immunosuppression from illness and medical therapy. Rational and effective treatment plans are needed. PMID: 19214354 [PubMed - in process] (Source: Skin Therapy Letter) Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=2186531 Thu, 01 Jan 2009 05:00:00 +0100 2186531 http://www.medworm.com/index.php?rid=2186530&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19214355%26dopt%3DAbstract Authors: Langner MD, Maibach HI Photosensitivity is defined as responsiveness to light exposure. For many common dermatologic drugs, proper storage conditions are essential for maintaining drug activity. Degradation and loss of activity can occur with exposure to light, temperature, and/ or moisture. For example, ketoconazole degrades after 24 hours of light exposure. In this article storage guidelines for common dermatology drugs are provided. We suspect that drug degradation is common due to improper storage and that improved patient instruction regarding storage will reduce degradation and alleviate some of the danger associated with improper storage and usage patterns. PMID: 19214355 [PubMed - in process] (Source: Skin Therapy Letter) Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=2186530 Thu, 01 Jan 2009 05:00:00 +0100 2186530 http://www.medworm.com/index.php?rid=2109898&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19145382%26dopt%3DAbstract Authors: Bartlett BL, Moody MN, Tyring SK Psoriasis is a common chronic inflammatory skin disease that is mediated, in part by the body's T-cell inflammatory response mechanisms. Further insight into the pathogenesis of the disease and the role of various cytokines, particularly interleukin(IL)-12 and IL-23, has led to advances in the treatment of this disease. A relatively new class of drugs that inhibit these interleukins is being developed and studied. Current data regarding the efficacy of these agents show they may have the potential to become the new clinical gold standard for biologic therapy to treat psoriasis. PMID: 19145382 [PubMed - in process] (Source: Skin Therapy Letter) Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=2109898 Mon, 01 Dec 2008 05:00:00 +0100 2109898 http://www.medworm.com/index.php?rid=2109897&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19145383%26dopt%3DAbstract Authors: Rivers JK As baby boomers get older, they have shown an increasing interest in maintaining a youthful appearance. As a result, there has been a corresponding increase in topical antiaging formulations, which are commonly referred to as cosmeceuticals. These products come with a seemingly limitless number of key active ingredients and claims of reducing the signs of aging and/or maintaining a youthful appearance. This paper reviews the more common cosmeceutical ingredients. PMID: 19145383 [PubMed - in process] (Source: Skin Therapy Letter) Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=2109897 Mon, 01 Dec 2008 05:00:00 +0100 2109897 http://www.medworm.com/index.php?rid=1862037&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18839042%26dopt%3DAbstract Authors: Altenburg A, Zouboulis CC The treatment of recurrent aphthous stomatitis (RAS) still remains nonspecific and is based primarily on empirical data. The goals of therapy include the management of pain and functional impairment by suppressing inflammatory responses, as well as reducing the frequency of recurrences or avoiding the onset of new aphthae. For common forms of RAS, standard topical treatment options that provide symptomatic relief include analgesics, anesthetics, antiseptics, anti-inflammatory agents, steroids, sucralfate, tetracycline suspension, and silver nitrate. Dietary modifications may also support therapeutic measures. In resistant cases of benign aphthosis or aphthosis with systemic involvement, appropriate systemic treatment can be selected from a wide spectr... Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=1862037 Mon, 01 Sep 2008 04:00:00 +0100 1862037 http://www.medworm.com/index.php?rid=1862036&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18839043%26dopt%3DAbstract Authors: Bogdan Allemann I, Baumann L The formation of free radicals is a widely accepted pivotal mechanism leading to skin aging. Free radicals are highly reactive molecules with unpaired electrons that can directly damage various cellular structural membranes, lipids, proteins, and DNA. The damaging effects of these reactive oxygen species are induced internally during normal metabolism and externally through various oxidative stresses. The production of free radicals increases with age, while the endogenous defense mechanisms that counter them decrease. This imbalance leads to the progressive damage of cellular structures, and thus, results in accelerated aging. Antioxidants are substances that can provide protection from endogenous and exogenous oxidative stresses by scavenging fre... Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=1862036 Mon, 01 Sep 2008 04:00:00 +0100 1862036 http://www.medworm.com/index.php?rid=1823587&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18806905%26dopt%3DAbstract Authors: Carruthers A, Carruthers J The tremendous success of botulinum toxin type A (BOTOX(R), Allergan Inc.) in the cosmetic arena has acted as a stimulus for the development of other neurotoxins. After more than 2 decades of use, BOTOX(R) has become synonymous with wrinkle reduction and is considered to be the one of the most common non-surgical cosmetic procedures performed worldwide. Because of its vast popularity among patients seeking non-invasive methods to achieve facial rejuvenation, physicians from diverse specialties have integrated botulinum toxin injections into their existing practices. Herein, we present an overview of botulinum toxin products for cosmetic applications that have received regulatory approval or are under development. PMID: 18806905 [PubMed - as suppl... Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=1823587 Tue, 01 Jul 2008 04:00:00 +0100 1823587 http://www.medworm.com/index.php?rid=1823586&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18806906%26dopt%3DAbstract This article will review some of the recent advances in photoprotection, including the development of sunscreen formulations offering higher and broader protection against solar radiation. PMID: 18806906 [PubMed - in process] (Source: Skin Therapy Letter) Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=1823586 Tue, 01 Jul 2008 04:00:00 +0100 1823586 http://www.medworm.com/index.php?rid=1651724&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18648712%26dopt%3DAbstract This article briefly reviews the pseudo-controversy , as well as the data supporting a revision of the recommendations for vitamin D supplementation. It concludes with a suggested message for patients, many of whom are understandably confused by recent media coverage of the topic. PMID: 18648712 [PubMed - in process] (Source: Skin Therapy Letter) Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=1651724 Sun, 01 Jun 2008 04:00:00 +0100 1651724 http://www.medworm.com/index.php?rid=1651723&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18648713%26dopt%3DAbstract Authors: Taglietti M, Hawkins CN, Rao J A vast spectrum of topical anti-acne agents has emerged in response to new insights that have been gained through the understanding of disease pathophysiology and the need for clinicians to adopt an individualized therapeutic approach. Because topical agents are most commonly used for acne management, this article reviews some novel vehicle delivery advances that are poised to further enhance the efficacy of topical acne formulations, and/or offer the possibility of simplified dosing regimens that may improve treatment outcomes. PMID: 18648713 [PubMed - in process] (Source: Skin Therapy Letter) Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=1651723 Sun, 01 Jun 2008 04:00:00 +0100 1651723 http://www.medworm.com/index.php?rid=1651722&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18648714%26dopt%3DAbstract Authors: Cordoro KM The choice of treatment for psoriasis in children, as in adults, is determined by disease acuity, morphology, distribution, severity, and the presence of comorbidities, such as psoriatic arthropathy. Fortunately, most patients present with mild disease that responds adequately to topical medications. A minor subset of children will present with severe, rapidly evolving disease that requires more aggressive interventions. Advanced medical treatment with systemic and phototherapy is challenging and primarily anecdotal, as these modalities are neither well-studied nor approved for use in children. Part II of this 2-part series features an overview of systemic and light therapies including their varying degrees of effectiveness, potential side-effects and applications i... Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=1651722 Thu, 01 May 2008 04:00:00 +0100 1651722 http://www.medworm.com/index.php?rid=1651721&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18648715%26dopt%3DAbstract Authors: Landells I, Maccallum C, Khraishi M Early diagnosis of psoriatic arthritis (PsA) is essential for preventing disease progression and joint destruction. The majority of patients develop PsA years after the onset of their skin disease. Therefore, dermatologists are in a strategic position to make the diagnosis of PsA, and either manage it or refer the patient to a rheumatologist in order to prevent the potentially irreversible destruction of the affected joints. We will review the presentation and temporal relationship of psoriasis and PsA, the diagnosis, classification, and management, in addition to the role of the dermatologist in the early detection of PsA. PMID: 18648715 [PubMed - in process] (Source: Skin Therapy Letter) Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=1651721 Thu, 01 May 2008 04:00:00 +0100 1651721 http://www.medworm.com/index.php?rid=1474280&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18506356%26dopt%3DAbstract Authors: Cordoro KM Psoriasis represents a potentially life-altering disease that can profoundly impact physical, emotional and social functioning, and overall quality of life. The majority of cases are mild and managed adequately with topical medications. A minor subset of children present with severe, rapidly evolving disease that requires systemic therapy. The choice of treatment in children, as in adults, is determined by disease acuity, morphology, distribution, severity and the presence of comorbidities such as psoriatic arthropathy. Practical considerations such as ease of use, patient acceptability, accessibility, risk to benefit ratio, cost and individual perceptions of disease and quality of life are factored into treatment decisions. Part I of this 2-part series will focus o... Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=1474280 Tue, 01 Apr 2008 04:00:00 +0100 1474280 http://www.medworm.com/index.php?rid=1474279&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18506357%26dopt%3DAbstract Authors: Prajapati V, Mydlarski PR The pemphigus variants represent a group of potentially life-threatening autoimmune mucocutaneous blistering diseases. Though systemic corticosteroids have dramatically reduced the rate of disease mortality, current therapeutic options are limited by their toxicity profiles. Advancements in our understanding of the molecular mechanisms involved in the pathogenesis of pemphigus have translated into the development of novel therapies. However, few treatments have been subject to randomized controlled trials to firmly establish therapeutic efficacy. Herein, we focus on the new and emerging therapies in the management of pemphigus. PMID: 18506357 [PubMed - as supplied by publisher] (Source: Skin Therapy Letter) Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=1474279 Tue, 01 Apr 2008 04:00:00 +0100 1474279 http://www.medworm.com/index.php?rid=1343304&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18373041%26dopt%3DAbstract Authors: Mahmoud BH, Hexsel CL, Hamzavi IH Vitiligo is an acquired leukoderma that results from the loss of epidermal melanocytes, and is characterized by macules and patches of depigmented skin. With a relatively high rate of prevalence, vitiligo occurs in localized, generalized, or segmental patterns; it can run a rapidly progressive course or remain stationary. The pathogenesis of vitiligo is not yet fully understood, but the autoimmune hypothesis is the most commonly accepted one, based on which, many treatment modalities have been described. Although many therapeutic options exist and new modalities are still emerging, treatment challenges persist, as not all patients respond to available therapies. Variables that affect the choice of treatment include the extent, distribution, an... Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=1343304 Sat, 01 Mar 2008 05:00:00 +0100 1343304 http://www.medworm.com/index.php?rid=1343303&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18373042%26dopt%3DAbstract Authors: A comprehensive list of drug treatments for skin disease including: Adapalene Gel 0.3% (Differin(R)), Drospirenone/ Ethinyl Estradiol (Yaz(R)), Tretinoin 0.05% Gel (Anthralin(R)), Daptomycin for Injection (CUBICIN(R)), Retapamulin Ointment 1% (Altabax(R)), Tinidazole Tablets (Tindamax(R)), Ciclopirox Topical Solution 8%, Ketoconazole 2% Foam (Extina(R)), Terbinafine Hydrochloride (Lamisil(R)), Desloratadine (Aerius(R)/ Azomyr(R)/ Neoclarityn(R)), Levocetirizine Dihydrochloride (Xyzal(R)), Loratadine Dry Syrup 1% (Claritin(R)) and many other treatments introduced in 2007. PMID: 18373042 [PubMed - in process] (Source: Skin Therapy Letter) Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=1343303 Sat, 01 Mar 2008 05:00:00 +0100 1343303 http://www.medworm.com/index.php?rid=1320703&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18357363%26dopt%3DAbstract Authors: Kourosh AS, Miner A, Menter A Psoriasis is associated with comorbidities that include metabolic syndrome and increased cardiovascular risk. These conditions share etiologic features and health consequences that directly correlate with the severity of psoriatic disease. This disease, in both its skin and joint manifestations, may represent a relevant healthcare issue as an indicator of a broader, underlying disorder of systemic inflammation, and warrants more comprehensive study and multidisciplinary collaboration on its pathophysiology, epidemiology, and treatment in relation to its comorbid conditions. PMID: 18357363 [PubMed - as supplied by publisher] (Source: Skin Therapy Letter) Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=1320703 Fri, 01 Feb 2008 05:00:00 +0100 1320703 http://www.medworm.com/index.php?rid=1320702&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18357364%26dopt%3DAbstract Authors: Lynde CB, Kraft JN, Lynde CW There exists a multitude of medical conditions that cause intractable itch, or pruritus. The successful management of this symptom depends explicitly on establishing the underlying cause. Studies have shown that drugs not traditionally used in the treatment of cutaneous disorders, such as opiate receptor antagonists, antidepressants, and antiepileptics, can provide symptomatic relief of intractable itch. These novel antipruritic agents will be explored in this review. PMID: 18357364 [PubMed - as supplied by publisher] (Source: Skin Therapy Letter) Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=1320702 Fri, 01 Feb 2008 05:00:00 +0100 1320702 http://www.medworm.com/index.php?rid=1188237&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18227953%26dopt%3DAbstract Authors: Gold MH Acne vulgaris can represent a therapeutic challenge in terms of managing ongoing symptoms and preventing scar formation. While the copious variations of available treatments address milder forms of the disease, until recently, therapies for resistant or moderate-to-severe forms were limited to systemic agents that were accompanied by potentially severe side-effects. With the addition of lasers, light sources, and aminolevulinic acid-photodynamic therapy (ALA-PDT) therapies, dermatologists may now have viable new alternatives for treating all grades of acne severity that circumvent the negative side-effects associated with many conventional options. PMID: 18227953 [PubMed - as supplied by publisher] (Source: Skin Therapy Letter) Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=1188237 Sat, 01 Dec 2007 05:00:00 +0100 1188237 http://www.medworm.com/index.php?rid=1188236&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18227954%26dopt%3DAbstract Authors: Zip C Optimal acne therapy must take into account not only acne type and severity, but also the impact of this skin disorder on the patients quality of life. Several validated instruments have been used to measure quality of life in acne patients. By using these instruments, acne patients have been shown to experience levels of social, psychological and emotional distress similar to those reported in patients with asthma, epilepsy and diabetes. Several studies have demonstrated that the disability caused by acne can be mitigated by effective therapy. PMID: 18227954 [PubMed - as supplied by publisher] (Source: Skin Therapy Letter) Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=1188236 Sat, 01 Dec 2007 05:00:00 +0100 1188236 http://www.medworm.com/index.php?rid=1105561&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18087657%26dopt%3DAbstract Authors: Draelos ZD The in-office dispensing of topical skin care products by dermatologists is a source of frequent debate. Guidelines for proper dispensing have been penned by various medical organizations, yet the controversy continues. With the increasing number of physician-dispensed lines available for sale, combined with mounting medical financial issues, the ongoing debate surrounding inoffice dispensing will continue. PMID: 18087657 [PubMed - as supplied by publisher] (Source: Skin Therapy Letter) Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=1105561 Thu, 01 Nov 2007 04:00:00 +0100 1105561 http://www.medworm.com/index.php?rid=1105560&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18087658%26dopt%3DAbstract Authors: Kircik L Hand and foot psoriasis is a chronic and debilitating disease that manifests as plaque-type or pustular-type lesions. Although the palms and soles represent only 2% of the total body surface area, psoriasis of these regions may lead to physical dysfunctions that can greatly impair dexterity, mobility, and the quality of life of affected individuals. Deregulation of T-lymphocyte-mediated immune response is important in the pathophysiology of psoriasis. Efalizumab (Raptiva(R), Genentech) is an anti-CD11a monoclonal antibody that disrupts the interaction between T cells and antigen-presenting cells, thereby inhibiting various T-cell-mediated immune processes that include activation and trafficking. Recent evidence indicates that efalizumab may be beneficial for patients ... Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=1105560 Thu, 01 Nov 2007 04:00:00 +0100 1105560 http://www.medworm.com/index.php?rid=1043310&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18026675%26dopt%3DAbstract This article will focus on three specific topics: eosinophilic folliculitis, psoriasis, and cutaneous mycoses. Their unique presentations in HIV and treatments are discussed. PMID: 18026675 [PubMed - as supplied by publisher] (Source: Skin Therapy Letter) Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=1043310 Mon, 01 Oct 2007 04:00:00 +0100 1043310 http://www.medworm.com/index.php?rid=1043309&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18026676%26dopt%3DAbstract This article will focus on the most popular, time-tested, and innovative fillers available today. PMID: 18026676 [PubMed - as supplied by publisher] (Source: Skin Therapy Letter) Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=1043309 Mon, 01 Oct 2007 04:00:00 +0100 1043309 http://www.medworm.com/index.php?rid=961220&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17940710%26dopt%3DAbstract Authors: Tan JK Oral contraceptives (OCs) are a valuable option for the treatment of women with acne. The use of OCs can be considered across the spectrum of acne disease severity in women. In Canada, three preparations are approved for mild-to-moderate acne, and a fourth is indicated for severe acne. These formulations contain estrogen in the form of ethinyl estradiol and a progestin. In Canada, the most recently approved OC is ethinyl estradiol 0.03mg and drospirenone 3mg (Yasmin(R), Bayer). With the accumulating evidence on the efficacy and safety of drospirenone-containing hormonal preparations, this formulation provides dermatologists with a new treatment option for acne and other hyperandrogenic disorders. PMID: 17940710 [PubMed - as supplied by publisher] (Source: Skin Thera... Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=961220 Sat, 01 Sep 2007 04:00:00 +0100 961220 http://www.medworm.com/index.php?rid=836330&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17762902%26dopt%3DAbstract Authors: Lacouture ME, Melosky BL The epidermal growth factor receptor (EGFR) is often overexpressed or dysregulated in solid tumors. Targeting the EGFR-mediated signaling pathway has become routine practice in the treatment of lung, pancreatic, head and neck, and colon carcinomas. Available agents with selected activity towards the EGFR include low molecular weight tyrosine kinase inhibitors, e.g., erlotinib (Tarceva(R), Genentech BioOncology/ OSI Pharmaceuticals/ F. Hoffmann-La Roche) and monoclonal antibodies, such as cetuximab (Erbitux(R), Bristol-Myers Squibb/ ImClone Systems/ Merck) and panitumumab (Vectibix(R), Amgen). Their use is anticipated to increase for treating other solid tumors that are dependent on this pathway for growth and proliferation. Health Canada and the US FDA... Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=836330 Wed, 01 Aug 2007 04:00:00 +0100 836330 http://www.medworm.com/index.php?rid=836329&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17762903%26dopt%3DAbstract Authors: Prajapati V, Mydlarski PR Rituximab (Rituxan(R), Genentech/ Biogen Idec) is a genetically engineered chimeric murine/human monoclonal antibody directed against CD20, a B lymphocyte-specific antigen. Initially approved for the treatment of relapsed or refractory low-grade or follicular non-Hodgkin's lymphoma (NHL), rituximab has been increasingly used to treat a variety of immune-mediated and autoimmune diseases. While anecdotal case reports recommend its "off-label" use in dermatology, randomized clinical trials are required to firmly establish the safety and efficacy of this emerging biologic therapy. PMID: 17762903 [PubMed - as supplied by publisher] (Source: Skin Therapy Letter) Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=836329 Wed, 01 Aug 2007 04:00:00 +0100 836329 http://www.medworm.com/index.php?rid=668714&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17551662%26dopt%3DAbstract Authors: Toole JW Psoriasis is a common skin disease affecting 1%-3% of the world's population with significant impacts on quality of life. There is a great need for therapies that are efficacious and safe, not only for the short-term, but also for long-term management. Dovobet(R)/ Daivobet(R)/ Taclonex(R) is a product combining two molecules, calcipotriol and betamethasone dipropionate, that may offer psoriatic patients with an option for maintenance therapy. The efficacy and safety of this combined formulation when used over a 4-week period is well documented. A recent publication in the British Journal of Dermatology discusses the safety of this product when used for 52 weeks. PMID: 17551662 [PubMed - as supplied by publisher] (Source: Skin Therapy Letter) Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=668714 Sun, 17 Jun 2007 01:26:51 +0100 668714 http://www.medworm.com/index.php?rid=668713&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17551663%26dopt%3DAbstract Authors: Drug Treatments for Skin Disease Introduced in 2006. PMID: 17551663 [PubMed - in process] (Source: Skin Therapy Letter) Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=668713 Sun, 17 Jun 2007 01:26:51 +0100 668713 http://www.medworm.com/index.php?rid=607933&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17487347%26dopt%3DAbstract Authors: Pirzada S, Tomi Z, Gulliver W Moderate-to-severe psoriasis is known to affect millions of people around the globe. This chronic disease substantially impacts patients by impairing their quality of life, causing psychosocial distress, and creating an ongoing financial burden. The biologics are the newest and most effective therapeutic weapon in the treatment of moderate-to-severe psoriasis and psoriatic arthritis that can significantly alter the course of the disease in a relatively short period of time. There is a need to review the recommended treatment guidelines for moderate- to-severe psoriasis and psoriatic arthritis as the perception and demands of patients are constantly changing. Real world experience with this class of drugs is expanding and more new biologics are bec... Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=607933 Sun, 01 Apr 2007 04:00:00 +0100 607933 http://www.medworm.com/index.php?rid=607932&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17487348%26dopt%3DAbstract Authors: Beer KR As the range of soft tissue augmentation products proliferates, most will be used (with varying degrees of success) to shape and augment the lip. The range of outcomes for this indication depends on the skill of the injector, the anatomy of the patient and the intrinsic properties of the product. Permutations of these interacting factors are infinite and it is the range of combinations that is responsible for the complexity (and fascination) of lip rejuvenation with injectable products. Based on personal experience, the perfect lip is the one that "wows" the patient and makes them happy with the procedure. Individualizing the injection is of paramount importance and should take priority over a formulaic approach that defines each lip injection as identical. This review... Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=607932 Sun, 01 Apr 2007 04:00:00 +0100 607932 http://www.medworm.com/index.php?rid=512474&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17393050%26dopt%3DAbstract Authors: Baldwin HE Rosacea is a common condition that affects people of all races. In addition to the visible aspects of this disease, it can have a psychosocial impact that must be evaluated when considering the treatment options. More aggressive and innovative uses of existing oral agents have resulted in novel therapeutic approaches, which can provide long-term therapy and sustained remission. PMID: 17393050 [PubMed - as supplied by publisher] (Source: Skin Therapy Letter) Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=512474 Thu, 01 Mar 2007 05:00:00 +0100 512474 http://www.medworm.com/index.php?rid=512472&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17393051%26dopt%3DAbstract Authors: Gladstone HB, Stewart D Dermatologic surgeons are often faced with the repair of complex facial defects following Mohs micrographic surgery. While the size or absence of critical tissue layers may be daunting, the reconstruction of these complex defects follow similar principles to those for the closure of smaller, simpler defects. There are several issues specific to these closures including whether to delay closure in order to allow wound contraction, thus decreasing the size of the wound. Yet, if the defect is adjacent to a fixed anatomic structure, this may not be an option. The tumescent technique allows for effective anesthesia over large surface areas. Although choosing a method of closure may be specific to the anatomic area, if possible, it is best to choose a 'workho... Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=512472 Thu, 01 Mar 2007 05:00:00 +0100 512472 http://www.medworm.com/index.php?rid=480910&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17361313%26dopt%3DAbstract Authors: Lovell P, Vender RB Pruritus, or itch, is a common sensation that causes a person to want to scratch. It is a complex process that may negatively impact quality of life and commonly occurs with skin disorders such as atopic dermatitis and urticaria. It could also be a symptom related to an underlying disease process such as cholestasis or hyperthyroidism, or simply be caused by dry skin, especially in the cold, winter months. Therapy is often aimed at eliminating the underlying cause first, followed by the management of the itchy sensation. Treatment may include prescription and over-the-counter (OTC) medications, herbal remedies, hydrotherapy, phototherapy, and ultraviolet therapy. This overview provides information regarding the various management and treatment options for p... Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=480910 Thu, 01 Feb 2007 05:00:00 +0100 480910 http://www.medworm.com/index.php?rid=480909&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17361314%26dopt%3DAbstract Authors: Mittmann N, Chan BC, Knowles S, Shear NH Intravenous immunoglobulin (IVIG) has been proposed as a treatment for toxic epidermal necrolysis (TEN) and Stevens-Johnson Syndrome (SJS). A number of retrospective and prospective studies have been conducted, with varying levels of evidence for the efficacy of IVIG. Recent publications provide opposing conclusions. A multi-center, comparative, long-term analysis needs to be conducted to determine the role of IVIG in the management of patients with SJS/TEN. PMID: 17361314 [PubMed - as supplied by publisher] (Source: Skin Therapy Letter) Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=480909 Thu, 01 Feb 2007 05:00:00 +0100 480909 http://www.medworm.com/index.php?rid=330419&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17180245%26dopt%3DAbstract Authors: Malcolm CE, Bergman JN Pediculosis capitis, or head lice, is a world-wide public health concern affecting persons of all ages and socioeconomic backgrounds. It is caused by Pediculus humanus capitis, an obligate ectoparasite that lives on human hair and feeds on the blood from the skin. Upon diagnosis, treatment should be initiated, since established infestations with head lice generally do not spontaneously resolve. Chemical pediculicides are currently the standard treatment, however, issues of resistance have made it necessary to explore new alternatives. If an infestation is resistant to these drugs, then the physician should consider treating with an agent from a different class of pediculicides or, potentially, with newer nonpediculicides. PMID: 17180245 [PubMed - in ... Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=330419 Sat, 23 Dec 2006 02:42:02 +0100 330419 http://www.medworm.com/index.php?rid=330418&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17180246%26dopt%3DAbstract Authors: Alam M, Dover JS Acne scarring is common but surprisingly difficult to treat. Scars can involve textural change in the superficial and deep dermis, and can also be associated with erythema, and less often, pigmentary change. In general, treatment of acne scarring is a multistep procedure. First, examination of the patient is necessary to classify the subtypes of scarring that are present. Then, the patient's primary concerns are elicited, and the patient is offered a menu of procedures that may address the various components of the scarring process. It is important to emphasize to the patient that acne scarring can be improved but never entirely reversed. PMID: 17180246 [PubMed - as supplied by publisher] (Source: Skin Therapy Letter) Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=330418 Sat, 23 Dec 2006 02:42:02 +0100 330418 http://www.medworm.com/index.php?rid=257632&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17075653%26dopt%3DAbstract Authors: Lynde CB, Kraft JN, Lynde CW Hyperpigmentation disorders of the skin are common and can be the source of significant psychosocial distress for patients. The most common of these disorders are melasma and postinflammatory hyperpigmentation. Sunscreen use and minimizing sun exposure are crucial in all cases. Topical applications are the mainstay of treatment and include phenols, retinoids, corticosteroids, and their combinations. PMID: 17075653 [PubMed - as supplied by publisher] (Source: Skin Therapy Letter) Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=257632 Wed, 01 Nov 2006 22:12:02 +0100 257632 http://www.medworm.com/index.php?rid=257631&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17075654%26dopt%3DAbstract Authors: Rahman Z, Alam M, Dover JS Fractional laser treatment with the 1,550nm erbium fiber laser (Fraxel Laser, Reliant Technologies) has bridged the gap between the ablative and nonablative laser modalities used to treat the epidermal and dermal signs of skin aging. By targeting water as its chromophore, the laser induces a dense array of microscopic, columnar thermal zones of tissue injury that do not perforate or impair the function of the epidermis. The significant skin remodeling that ensues can be used to treat, with limited downtime, epidermal pigmentation, melasma, and rhytides, as well as textural abnormalities that include acne-related and surgical scars. PMID: 17075654 [PubMed - as supplied by publisher] (Source: Skin Therapy Letter) Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=257631 Wed, 01 Nov 2006 22:12:02 +0100 257631 http://www.medworm.com/index.php?rid=226728&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17024293%26dopt%3DAbstract Authors: Flammiger A, Maibach H The elderly population is increasing and drug dosing requires special considerations for efficacy and decreasing toxicity. This overview provides algorithms for adjusting drug and dosage based on current evidence-based knowledge with emphasis on drugs prescribed in dermatological practice. PMID: 17024293 [PubMed - as supplied by publisher] (Source: Skin Therapy Letter) Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=226728 Sun, 08 Oct 2006 20:54:02 +0100 226728 http://www.medworm.com/index.php?rid=226727&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17024294%26dopt%3DAbstract Authors: Lin JY, Chan HH The development of selective photothermolysis has enabled removal of targets such as melanin. Both lasers and intense pulsed light (IPL) sources have been used in the treatment of pigmented lesions, however careful selection is important to ensure success. This is especially true in darker skinned individuals where the risk of postinflammatory hyperpigmentation (PIH) is high. The advent of the Q-switched laser, IPL, and now fractional photothermolysis (Fraxel, Reliant Technologies) offers a variety of ways to treat epidermal and dermal pigmentary disorders. PMID: 17024294 [PubMed - as supplied by publisher] (Source: Skin Therapy Letter) Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=226727 Sun, 08 Oct 2006 20:54:02 +0100 226727 http://www.medworm.com/index.php?rid=224996&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17021645%26dopt%3DAbstract This article will focus on practical management strategies for IDD. PMID: 17021645 [PubMed - as supplied by publisher] (Source: Skin Therapy Letter) Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=224996 Sat, 07 Oct 2006 04:38:02 +0100 224996 http://www.medworm.com/index.php?rid=224995&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17021646%26dopt%3DAbstract Authors: Bogle MA Plasma skin regeneration (PSR) technology uses energy delivered from plasma rather than light or radiofrequency. Plasma is the fourth state of matter in which electrons are stripped from atoms to form an ionized gas. The plasma is emitted in a millisecond pulse to deliver energy to target tissue upon contact without reliance on skin chromophores. The technology can be used at varying energies for different depths of effect, from superficial epidermal sloughing to deeper dermal heating. With the Portrait PSR device (Rhytec, Inc.) there are three treatment guidelines termed PSR1, PSR2, and PSR3. The PSR1 protocol uses a series of low-energy treatments (1.0,1.2 Joules) spaced 3 weeks apart. The PSR2 protocol uses one high-energy pass (3.0, 4.0 Joules) performed in a sing... Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=224995 Sat, 07 Oct 2006 04:38:02 +0100 224995 http://www.medworm.com/index.php?rid=149425&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16912836%26dopt%3DAbstract Authors: Speck LM, Tyring SK Human papillomavirus (HPV) infection is the known cause of almost all cases of cervical cancer. An understanding of the HPV genome has allowed the development of two prophylactic vaccines capable of protecting against both persistent HPV infection and cervical intraepithelial neoplasia (CIN) with 100% efficacy in fully vaccinated women. The vaccines, manufactured by Merck (Gardasil(R), which was approved by the US FDA in June, 2006) and GlaxoSmithKline (Cervarix(R), which will be submitted for US FDA approval by the end of 2006), both target HPV types 16 and 18, which together account for 70% of cervical cancer. Merck vaccine also targets HPV 6 and 11, covering =90% of genital warts. These vaccines are highly immunogenic and have an excellent safety profile... Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=149425 Mon, 14 Aug 2006 06:00:00 +0100 149425 http://www.medworm.com/index.php?rid=149424&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16912837%26dopt%3DAbstract We describe our approach to lip repair and present novel methods to maintain symmetry and function, and optimize cosmetic results. PMID: 16912837 [PubMed - as supplied by publisher] (Source: Skin Therapy Letter) Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=149424 Mon, 14 Aug 2006 06:00:00 +0100 149424 http://www.medworm.com/index.php?rid=106676&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16820869%26dopt%3DAbstract Authors: Berman B, Perez OA, Zell D Skin cancer is the most common human cancer, and is currently considered a global epidemic. Recently, there has been a growing interest in immunomodulators, or up-regulators of the immune response, for the treatment and cure of various forms of skin cancer, including melanoma and nonmelanoma skin cancers, cutaneous T-cell lymphoma, Kaposi's sarcoma, cutaneous extramammary Paget's disease, and vulvar intraepithelial carcinoma neoplasia. Strategies to augment the host's immune response against cancer cells and/or cancer cell antigenicity have been investigated, including recombinant cytokines, immunomodulators, dendritic cell immunization, tumor antigen vaccination, T-cell-based immunotherapy, and gene therapy. Although the current standard of care for... Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=106676 Wed, 14 Jun 2006 06:00:00 +0100 106676 http://www.medworm.com/index.php?rid=106675&cid=s_31722_12_f&fid=31722&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16820870%26dopt%3DAbstract We present our clinical experience along with literature findings on decorative tattoo removal and the important issues practitioners should consider in the management of tattoos. PMID: 16820870 [PubMed - as supplied by publisher] (Source: Skin Therapy Letter) Skin Therapy Letter journals http://www.medworm.com/rss/comments.php?id=106675 Wed, 14 Jun 2006 06:00:00 +0100 106675