MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Surgical Pathology Clinics' source. Sat, 30 Jan 2010 15:09:51 +0100 http://www.medworm.com/index.php?rid=3038006&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109001007%2Fabstract%3Frss%3Dyes (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3038006 Mon, 30 Nov 2009 15:12:19 +0100 3038006 http://www.medworm.com/index.php?rid=3038005&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109000658%2Fabstract%3Frss%3Dyes Abstract: Mesenchymal tumors of the female genital tract include various benign and malignant neoplasms. Mesenchymal tumors may arise from the stroma or associated elements of the organ of origin, such as connective tissue, vascular or neural structures, or others. Malignant mesenchymal tumors of the female genital tract represent a rare group of gynecologic cancers. They are generally aggressive tumors, with a propensity for local and distant recurrence. The mainstay of treatment usually involves surgical excision of the primary tumor. Malignant mesenchymal tumors of the female genital tract are generally refractory to systemic chemotherapy and radiation therapy. This review highlights the treatment options for the most common types of mesenchymal tumors of the female genital tract. (Sour... Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3038005 Mon, 30 Nov 2009 15:12:19 +0100 3038005 http://www.medworm.com/index.php?rid=3038004&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109000646%2Fabstract%3Frss%3Dyes This article focuses on current understanding of the molecular genetics of mesenchymal tumors of the female genital tract, with emphasis on diagnostic and prognostic molecular features. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3038004 Mon, 30 Nov 2009 15:12:19 +0100 3038004 http://www.medworm.com/index.php?rid=3038003&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109000634%2Fabstract%3Frss%3Dyes This article reviews the information currently available on genetic changes in mesenchymal tumors of the female genital tract and, more specifically, those reported in the uterus, where they have been more frequently studied. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3038003 Mon, 30 Nov 2009 15:12:19 +0100 3038003 http://www.medworm.com/index.php?rid=3038002&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109000610%2Fabstract%3Frss%3Dyes Abstract: Pure mesenchymal tumors may occur anywhere in the female genital tract, but they are most common in the uterine corpus, leiomyoma being by far the most prevalent. These tumors, and other uncommon mesenchymal lesions within the uterine corpus and elsewhere in the female genital tract, may result in several diagnostic problems. Morphology remains paramount and, in most cases, an unequivocal diagnosis can be made based on examination of the hematoxylin and eosin stained sections, combined with an appreciation of the clinical and gross pathologic features. In difficult cases, immunohistochemistry can significantly contribute to the final diagnosis. In this article, the immunohistochemistry of neoplastic and nonneoplastic mesenchymal lesions of the female genital tract is discussed si... Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3038002 Mon, 30 Nov 2009 15:12:19 +0100 3038002 http://www.medworm.com/index.php?rid=3038001&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109000609%2Fabstract%3Frss%3Dyes This article outlines several mesenchymal lesions reported in the female genital tract, encompassing recent histologic, immunohistochemical, and molecular findings, with special emphasis on problems in the differential diagnosis. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3038001 Mon, 30 Nov 2009 15:12:18 +0100 3038001 http://www.medworm.com/index.php?rid=3038000&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109000580%2Fabstract%3Frss%3Dyes This article reviews fibromatous ovarian tumors, emphasizing cellular fibromas and their differential diagnosis. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3038000 Mon, 30 Nov 2009 15:12:18 +0100 3038000 http://www.medworm.com/index.php?rid=3037999&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109000592%2Fabstract%3Frss%3Dyes Abstract: Malignant mixed müllerian tumor (MMMT) and müllerian/mesodermal adenosarcoma are 2 of the most common mixed müllerian tumors of the female genital tract. MMMT is a biphasic neoplasm, composed of morphologically malignant epithelial and stromal components. MMMT should be distinguished from endometrioid adenocarcinoma with spindle cell elements, “dedifferentiated” endometrioid carcinoma, and combined adenocarcinoma and neuroendocrine carcinoma. Adenosarcoma is also biphasic; it is composed of morphologically benign or low-grade appearing epithelial components and malignant stromal components. The differential diagnosis of adenosarcoma includes MMMT, endometrial stromal tumor containing endometrioid glands, benign endometrial or endocervical polyp, adenofibroma, adenomyoma, ... Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3037999 Mon, 30 Nov 2009 15:12:18 +0100 3037999 http://www.medworm.com/index.php?rid=3037998&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS187591810900066X%2Fabstract%3Frss%3Dyes Abstract: Endometrial/ioid stromal tumors comprise a spectrum of mesenchymal neoplasms, ranging from benign to low-grade malignancy to undifferentiated sarcomas, which occur predominantly in the uterus but may rarely originate at extrauterine sites, most commonly in the ovary. These tumors and their morphologic variants are important to recognize as they often cause diagnostic difficulties. This review focuses on the diagnostic criteria and differential diagnosis, including the role of immunohistochemistry. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3037998 Mon, 30 Nov 2009 15:12:18 +0100 3037998 http://www.medworm.com/index.php?rid=3037997&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109000622%2Fabstract%3Frss%3Dyes This article discusses conventional smooth muscle tumors as well as unusual subtypes, with emphasis on the diagnostic criteria and problems in differential diagnosis that arise at each site within the female genital tract. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3037997 Mon, 30 Nov 2009 15:12:18 +0100 3037997 http://www.medworm.com/index.php?rid=3037996&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109000579%2Fabstract%3Frss%3Dyes Abstract: A variety of site-specific mesenchymal lesions of the lower genital tract may occur, which are often diagnostically challenging because of their morphologic overlap. Some of this morphologic homogeneity presumably stems from a potentially shared origin from the specialized superficial stroma of the distal female genital tract. Despite shared appearances, morphologic distinction remains the gold standard for diagnosis of most of these lesions, as immunoperoxidase staining is often not helpful in their distinction. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3037996 Mon, 30 Nov 2009 15:12:18 +0100 3037996 http://www.medworm.com/index.php?rid=3037995&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109000567%2Fabstract%3Frss%3Dyes This article highlights the imaging features of the most commonly encountered mesenchymal tumors in the female genital tract. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3037995 Mon, 30 Nov 2009 15:12:18 +0100 3037995 http://www.medworm.com/index.php?rid=3037994&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109000804%2Fabstract%3Frss%3Dyes Among the spectrum of neoplasms that involve the female genital tract, mesenchymal tumors, albeit uncommon, represent one of the most challenging areas in our practice. The main goal of this issue of The Surgical Pathology Clinics series on mesenchymal tumors of the female genital tract is to approach these relatively unusual tumors in a systematic, practical, and integrated fashion, while providing at the same time a comprehensive and updated review. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3037994 Mon, 30 Nov 2009 15:12:18 +0100 3037994 http://www.medworm.com/index.php?rid=3037993&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109000993%2Fabstract%3Frss%3Dyes (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3037993 Mon, 30 Nov 2009 15:12:18 +0100 3037993 http://www.medworm.com/index.php?rid=3037992&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109000981%2Fabstract%3Frss%3Dyes (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3037992 Mon, 30 Nov 2009 15:12:18 +0100 3037992 http://www.medworm.com/index.php?rid=2945776&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109000749%2Fabstract%3Frss%3Dyes (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=2945776 Tue, 01 Sep 2009 00:00:00 +0100 2945776 http://www.medworm.com/index.php?rid=2945775&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109000531%2Fabstract%3Frss%3Dyes This article describes the handful of “signature” changes that are known to occur, describes how some recent studies have shed light on changes beyond this signature, and finally discusses the impact of molecular pathology for practicing histopathologists. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=2945775 Tue, 01 Sep 2009 00:00:00 +0100 2945775 http://www.medworm.com/index.php?rid=2945774&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109000488%2Fabstract%3Frss%3Dyes Abstract: Examination of sentinel lymph nodes (SLN) has probably become the most popular method of early staging of patients who have cutaneous melanoma because SLN are considered to be the lymph nodes most likely to contain metastatic deposits; they can be examined in a more intense manner than in standard lymphadenectomy. There are several protocols to examine SLN but most of them use formalin-fixed, paraffin-embedded sections stained with hematoxylin and eosin with the addition of immunohistochemistry. By using these protocols, approximately 20% of patients who have cutaneous melanoma have melanoma cells in the SLN. Current studies are evaluating the possible therapeutic value of removal of positive SLN, but it is accepted by most authors that detection of positive SLN conveys an impair... Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=2945774 Tue, 01 Sep 2009 00:00:00 +0100 2945774 http://www.medworm.com/index.php?rid=2945773&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109000476%2Fabstract%3Frss%3Dyes Abstract: Primary cutaneous melanoma is treated by excisional surgery and careful histologic assessment of the specimen margins is a crucial component of pathology reporting. Surgical margins may be assessed by conventional transverse (bread-loaf) vertical sections, by en face vertical sections, or by en face oblique sections. Transverse techniques only sample a small percentage of the surgical margin. En face techniques are technically challenging but allow assessment of close to 100% of the margin. Margin assessment for melanoma removed from chronically sun-damage skin is difficult. Melanoma in situ shows contiguous melanocyte growth, nesting, or intraepidermal pagetoid spread. Pitfalls include solar melanocytic hyperplasia, solar lentigines, melanocytic hyperplasia secondary to previous... Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=2945773 Tue, 01 Sep 2009 00:00:00 +0100 2945773 http://www.medworm.com/index.php?rid=2945772&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109000464%2Fabstract%3Frss%3Dyes Abstract: Acral lentiginous melanoma is an uncommon skin malignancy that occurs with equal frequency in all races and has a worse prognosis than other types of melanoma; it presents as dark, irregular macules, papules, or nodules on the feet and, less commonly, the hands. The histologic findings of acral lentiginous melanoma are characterized by an asymmetric, poorly circumscribed proliferation of continuous single melanocytes at the dermoepidermal junction. Single melanocytes predominate over nests. The tumor must be distinguished from benign acral lentiginous nevi, which can display site-related atypia. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=2945772 Tue, 01 Sep 2009 00:00:00 +0100 2945772 http://www.medworm.com/index.php?rid=2945771&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS187591810900052X%2Fabstract%3Frss%3Dyes This article discusses the key features of nevoid melanoma. Gross features, microscopic features, immunohistochemistry, differential diagnosis, diagnosis, prognosis, and treatment are also discussed. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=2945771 Tue, 01 Sep 2009 00:00:00 +0100 2945771 http://www.medworm.com/index.php?rid=2945770&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109000518%2Fabstract%3Frss%3Dyes Abstract: Desmoplastic melanoma (DM) is a variant of spindle cell melanoma characterized by the presence of abundant fibrous matrix. It is typically found in the head and neck region on chronically sun-damaged skin of older individuals. Early detection is uncommon, because its clinical features are not distinctive. DM is prone to misdiagnosis not only clinically but also histologically. It may simulate a sclerosing melanocytic nevus and various benign and malignant nonmelanocytic lesions. Among melanomas said to be desmoplastic by various pathologists there is significant variation with regard to the extent of intratumoral fibrosis. It may be prominent throughout the entire tumor (pure DM) or represent a portion of an otherwise nondesmoplastic melanoma (combined DM). Immunophenotypically, ... Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=2945770 Tue, 01 Sep 2009 00:00:00 +0100 2945770 http://www.medworm.com/index.php?rid=2945769&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109000506%2Fabstract%3Frss%3Dyes Abstract: Spitz nevi and melanoma represent benign and malignant counterparts commonly coupled in the same differential diagnosis. The precise distinction between the two entities remains an ongoing challenge in dermatopathology and surgical pathology. In past years, considerable work has been devoted to the assembly of criteria to permit exact diagnosis. Although diagnostic accuracy has improved, many lesions remain challenging to classify based solely upon conventional microscopic criteria. In this article, the clinical and histopathological attributes of Spitz nevi and spitzoid melanoma are reviewed. Lesions that cannot be definitively classified based solely upon conventional microscopic criteria are referred to as atypical spitzoid neoplasms, which the authors view as a provisional di... Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=2945769 Tue, 01 Sep 2009 00:00:00 +0100 2945769 http://www.medworm.com/index.php?rid=2945768&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109000555%2Fabstract%3Frss%3Dyes This article succinctly describes the common dermal dendritic proliferations and updates readers on newly classified entities and variants. The differential diagnosis of the main entities and strategies to distinguish them from their melanocytic and nonmelanocytic mimics is also presented. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=2945768 Tue, 01 Sep 2009 00:00:00 +0100 2945768 http://www.medworm.com/index.php?rid=2945767&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS187591810900049X%2Fabstract%3Frss%3Dyes Abstract: Melanocytic nevi can have a wide range of histologic appearances. Within the spectrum of nevi, there exists a group that presents in certain anatomic locations with histologically worrisome features but nonetheless benign behavior. This group of nevi has been broadly categorized as nevi of special sites. The anatomic locations affected by this group include the embryonic milkline (breast, axillae, umbilicus, genitalia), flexural areas, acral surfaces, ear, and scalp. Nevi in these locations may be mistaken for melanomas because of their histologic appearance, resulting in inappropriate overtreatment of patients. In this article, the authors review the histologic features of these special site nevi and discuss the criteria that help distinguish them from melanoma. (Source: Surgica... Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=2945767 Tue, 01 Sep 2009 00:00:00 +0100 2945767 http://www.medworm.com/index.php?rid=2945766&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109000452%2Fabstract%3Frss%3Dyes This article reviews congenital melanocytic nevi (CMN), which are present at birth or appear shortly thereafter, and their main histologic features. Several histologic variants and histopathologic criteria that differentiate CMN from other nevi, such as atypical or dysplastic nevi, and from nevoid malignant melanoma, are discussed. Histologic pitfalls in the correct identification of lentiginous melanocytic hyperplasia, pagetoid scatter, and proliferative nodules in the context of CMN are discussed. The risk for development of malignant melanoma in association with a congenital melanocytic nevus and variable causes for changing mole are discussed. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=2945766 Tue, 01 Sep 2009 00:00:00 +0100 2945766 http://www.medworm.com/index.php?rid=2945765&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109000440%2Fabstract%3Frss%3Dyes This article discusses the gross, clinical and microscopic features; diagnosis; and prognosis of dysplastic nevi. The key features and pitfalls of diagnosing malignant melanoma, congenital nevus, and recurrent nevus are given. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=2945765 Tue, 01 Sep 2009 00:00:00 +0100 2945765 http://www.medworm.com/index.php?rid=2945764&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109000543%2Fabstract%3Frss%3Dyes Dermatopathology is an ever-changing field in the area of surgical pathology. Despite many advances, interpretation of melanocytic neoplasms remains a significant source of diagnostic difficulty encountered by surgical pathologists every day. “Is this lesion an unusual nevus?” and “Is this a subtle variant of melanoma?” are common dilemmas and questions faced on a daily basis. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=2945764 Tue, 01 Sep 2009 00:00:00 +0100 2945764 http://www.medworm.com/index.php?rid=2945763&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109000737%2Fabstract%3Frss%3Dyes (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=2945763 Tue, 01 Sep 2009 00:00:00 +0100 2945763 http://www.medworm.com/index.php?rid=2945762&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109000725%2Fabstract%3Frss%3Dyes (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=2945762 Tue, 01 Sep 2009 00:00:00 +0100 2945762 http://www.medworm.com/index.php?rid=2481603&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109000270%2Fabstract%3Frss%3Dyes (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=2481603 Mon, 01 Jun 2009 04:00:00 +0100 2481603 http://www.medworm.com/index.php?rid=2481602&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109000191%2Fabstract%3Frss%3Dyes Abstract: Breast lesions associated with extracellular mucin production are uncommon and constitute a wide spectrum of lesions ranging from benign cyst to mucinous carcinoma. Intracytoplasmic mucin can be seen rarely in benign metaplasias but is a common finding in invasive and in situ carcinomas. In this article, we discuss the differential diagnosis of breast lesions associated with mucin production and other entities that show histologic changes that mimic mucin production. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=2481602 Mon, 01 Jun 2009 04:00:00 +0100 2481602 http://www.medworm.com/index.php?rid=2481601&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS187591810900018X%2Fabstract%3Frss%3Dyes Abstract: Because of the singular anatomic structure of the nipple, some breast lesions only occur at this site. The overlying skin includes normal Toker cells near the duct orifices. These cells are occasionally so numerous as to be called Toker cell hyperplasia. Ductal carcinoma in situ (DCIS) may involve nipple skin by direct extension from the underlying ducts (Paget disease of the nipple). The numerous skin appendages (eg, sebaceous, apocrine, and eccrine glands) in the nipple and areola are the likely origin of syringomatous adenomas. At the duct orifices, the normal squamous epithelium dips into the breast for a short distance and abruptly transitions to glandular luminal and myoepithelial cells. When keratin-producing cells extend deeper into the ducts, the condition of squamous me... Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=2481601 Mon, 01 Jun 2009 04:00:00 +0100 2481601 http://www.medworm.com/index.php?rid=2481600&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109000178%2Fabstract%3Frss%3Dyes Abstract: Spindle cell lesions of the breast represent a heterogeneous group of reactive and neoplastic disorders that commonly present diagnostic challenges. Arguably, the most important of these lesions to recognize is spindle cell carcinoma, a type of metaplastic carcinoma. This review focuses on those spindle cell lesions of the breast that are most likely to be encountered in clinical practice or that produce particular diagnostic difficulties. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=2481600 Mon, 01 Jun 2009 04:00:00 +0100 2481600 http://www.medworm.com/index.php?rid=2481599&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109000117%2Fabstract%3Frss%3Dyes Abstract: Immunohistochemical markers for myoepithelial cells are commonly used to distinguish invasive from noninvasive lesions in the breast. The approach takes advantage of the fact that conventional invasive carcinomas lack surrounding myoepithelial cells, whereas nearly all benign lesions and in situ carcinomas retain their myoepithelial cell layer. Although conceptually straightforward, the interpretation of myoepithelial cell markers can be complicated by misleading patterns of reactivity (such as stromal or tumor cell staining) or lack of reactivity (due to reduced numbers of myoepithelial cells or variable antigenicity). In this article, we discuss the advantages and disadvantages of commonly used myoepithelial cell markers, their general utility in distinguishing invasive from ... Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=2481599 Mon, 01 Jun 2009 04:00:00 +0100 2481599 http://www.medworm.com/index.php?rid=2481598&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109000166%2Fabstract%3Frss%3Dyes This article focuses on encapsulated papillary carcinoma, a recently proposed term used to describe papillary carcinoma occurring within a cystically dilated duct. Previously considered a variant of papillary ductal carcinoma in situ, the finding that these lesions typically lack myoepithelial cells at their periphery has raised questions about their true nature. This article presents a practical approach to the diagnosis of encapsulated papillary carcinoma with a review of its histologic mimics and clinical significance. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=2481598 Mon, 01 Jun 2009 04:00:00 +0100 2481598 http://www.medworm.com/index.php?rid=2481597&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109000142%2Fabstract%3Frss%3Dyes This article focuses on current issues relating to fibroepithelial lesions, predominantly those with cellular stroma, and covers key pathologic features, differential diagnosis, and pitfalls. Phyllodes tumors are emphasized, including the histologic categorization and prognostic features of these lesions. The management of fibroepithelial lesions on needle core biopsy is reviewed. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=2481597 Mon, 01 Jun 2009 04:00:00 +0100 2481597 http://www.medworm.com/index.php?rid=2481596&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109000105%2Fabstract%3Frss%3Dyes Abstract: The morphologic spectrum of lobular carcinoma in situ (LCIS) includes the classical type and unusual variants recently described. In this article we review the morphology of LCIS and highlight ways to distinguish it from its morphologic mimickers. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=2481596 Mon, 01 Jun 2009 04:00:00 +0100 2481596 http://www.medworm.com/index.php?rid=2481595&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109000130%2Fabstract%3Frss%3Dyes Abstract: Lesions of the breast characterized by enlarged terminal duct lobular units lined by columnar epithelial cells are being encountered increasingly in breast biopsy specimens. Some of these lesions feature cuboidal to columnar epithelial cells in which the lining cells exhibit cytologic atypia. The role of these lesions (recently designated “flat epithelial atypia” [FEA]) in breast tumor progression is still emerging. FEA commonly coexists with well-developed examples of atypical ductal hyperplasia, low-grade ductal carcinoma in situ, lobular neoplasia, and tubular carcinoma. These findings and those of recent genetic studies suggest that FEA is a neoplastic lesion that may represent a precursor to or the earliest morphologic manifestation of ductal carcinoma in situ. Additiona... Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=2481595 Mon, 01 Jun 2009 04:00:00 +0100 2481595 http://www.medworm.com/index.php?rid=2481594&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109000129%2Fabstract%3Frss%3Dyes This article focuses on histopathology, molecular characterization, carcinogenesis, clinical behavior, and treatment of these tumors. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=2481594 Mon, 01 Jun 2009 04:00:00 +0100 2481594 http://www.medworm.com/index.php?rid=2481593&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109000099%2Fabstract%3Frss%3Dyes This article presents s conceptual and practical understanding of these processes and their impact on subsequent cancer risk, with the intention of assisting the practicing pathologist render accurate and clinically relevant diagnoses for this frequently encountered set of mammary epithelial lesions. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=2481593 Mon, 01 Jun 2009 04:00:00 +0100 2481593 http://www.medworm.com/index.php?rid=2481592&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109000154%2Fabstract%3Frss%3Dyes Breast pathology can be challenging for all of us involved in diagnostic surgical pathology. Several areas of breast pathology are particularly difficult or problematic. Breast pathology is the focus of this issue of the Surgical Pathology Clinics series, and experts in the field have provided comprehensive reviews of commonly encountered problematic lesions in breast pathology, including proliferative epithelial lesions, fibroepithelial lesions, mucinous lesions, and spindle cell lesions. Additionally, this issue includes a state-of-the-art review of the use of myoepithelial markers in the differential diagnosis of benign, in situ, and invasive lesions, a differential diagnostic situation that many of us encounter daily. Finally, there is an article covering the topic of triple-negative b... Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=2481592 Mon, 01 Jun 2009 04:00:00 +0100 2481592 http://www.medworm.com/index.php?rid=2481591&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109000269%2Fabstract%3Frss%3Dyes (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=2481591 Mon, 01 Jun 2009 04:00:00 +0100 2481591 http://www.medworm.com/index.php?rid=2481590&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109000257%2Fabstract%3Frss%3Dyes (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=2481590 Mon, 01 Jun 2009 04:00:00 +0100 2481590