MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Surgical Pathology Clinics' source. Mon, 30 Jan 2012 02:02:16 +0100 http://www.medworm.com/index.php?rid=5402067&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS187591811100256X%2Fabstract%3Frss%3Dyes (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=5402067 Sun, 13 Nov 2011 17:11:53 +0100 5402067 http://www.medworm.com/index.php?rid=5402066&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918111001474%2Fabstract%3Frss%3Dyes This article describes the clinical, radiographic, and pathologic features of tumors and tumorlike lesions affecting the bones of the head and neck region. Emphasis is placed on common bone lesions affecting the craniofacial skeleton, particularly those that occur with more frequency or those that are unique to this part of the skeleton. Several of these lesions pose a diagnostic challenge to the pathologist. To ensure that a correct diagnosis is rendered, it is of utmost importance that accurate and detailed clinical and radiographic information is available. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=5402066 Sun, 13 Nov 2011 17:11:53 +0100 5402066 http://www.medworm.com/index.php?rid=5402065&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918111001498%2Fabstract%3Frss%3Dyes Abstract: Although at least 24 distinct histologic salivary gland carcinomas exist, many of them are rare, comprising only 1% to 2% of all salivary gland tumors. These include epithelial-myoepithelial carcinoma, (hyalinizing) clear cell carcinoma, basal cell adenocarcinoma, cystadenocarcinoma, low-grade salivary duct carcinoma (low-grade cribriform cystadenocarcinoma), oncocytic carcinoma, and adenocarcinoma not otherwise specified. Few tumors (clear cell carcinoma and basal cell adenocarcinoma) have unique molecular correlates. Benign tumors, although histologically less diverse, are far more common, with pleomorphic adenoma and Warthin tumor the most common salivary gland tumors. Many benign tumors have malignant counterparts for which histologic distinction can pose diagnostic challenge... Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=5402065 Sun, 13 Nov 2011 17:11:53 +0100 5402065 http://www.medworm.com/index.php?rid=5402064&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918111001486%2Fabstract%3Frss%3Dyes Abstract: Malignant salivary gland epithelial tumors are histologically diverse with at least 24 recognized distinct entities. In general, malignant tumors account for 15% to 30% of parotid tumors, 40% to 45% of submandibular tumors, 70% to 90% of sublingual tumors, and 50% of minor salivary tumors. Common malignancies include mucoepidermoid carcinoma, adenoid cystic carcinoma, acinic cell carcinoma, salivary duct carcinoma, carcinoma ex pleomorphic adenoma, polymorphous lowgrade adenocarcinoma, and myoepithelial carcinoma. Each tumor type has its own unique histologic variants and prognostic pathologic features, and only mucoepidermoid carcinomas have a formalized grading system. The molecular pathogenesis of certain tumors, such as mucoepidermoid carcinoma and adenoid cystic carcinoma, h... Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=5402064 Sun, 13 Nov 2011 17:11:53 +0100 5402064 http://www.medworm.com/index.php?rid=5402063&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918111001723%2Fabstract%3Frss%3Dyes This article places emphasis on illustrating the classical pathologic characteristics, differential diagnosis, clinical significance, and presentation of common lesions unique to these sites. The initial diagnosis of these lesions is via small endoscopic biopsy. Many of the entities have overlapping histologic features which necessitate optimizing the information available in a small sample. The focus of this article is to provide useful criteria to enable separating the more common types of lesions encountered in these sites. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=5402063 Sun, 13 Nov 2011 17:11:53 +0100 5402063 http://www.medworm.com/index.php?rid=5402062&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918111001450%2Fabstract%3Frss%3Dyes This article discusses variants of oral and oropharyngeal SCC and highlights those features that help distinguish human papillomavirus–related from human papillomavirus–unrelated SCC. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=5402062 Sun, 13 Nov 2011 17:11:53 +0100 5402062 http://www.medworm.com/index.php?rid=5402061&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918111001735%2Fabstract%3Frss%3Dyes This article concentrates on some of the more common types of benign and malignant neoplasms. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=5402061 Sun, 13 Nov 2011 17:11:53 +0100 5402061 http://www.medworm.com/index.php?rid=5402060&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918111001462%2Fabstract%3Frss%3Dyes This article presents various odontogenic cysts and tumors, including periapical cysts, dentigerous cysts, odontogenic keratocysts, orthokeratinized odontogenic cysts, lateral periodontal cysts, glandular odontogenic cysts, ameloblastomas, clear cell odontogenic carcinomas, adenomatoid odontogenic tumors, calcifying epithelial odontogenic tumors, squamous odontogenic tumors, ameloblastic fibromas, ameloblastic fibro-odontomas, odontomas, calcifying cystic odontogenic tumors, and odontogenic myxomas. The authors provide an overview of these cysts and tumors, with microsopic features, gross features, differential diagnosis, prognosis, and potential diagnostic pitfalls. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=5402060 Sun, 13 Nov 2011 17:11:53 +0100 5402060 http://www.medworm.com/index.php?rid=5402059&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918111001449%2Fabstract%3Frss%3Dyes Abstract: Lichenoid changes in the oral mucosa can be encountered in a wide range of lesions and can have varied etiologies. Immune-mediated disorders, including lichen planus, mucous membrane pemphigoid, discoid lupus erythematosus, and graft-versus-host disease, can have clinical and histologic overlaps. Lichenoid reactions to dental materials, such as amalgam, or to many systemic drugs are also well documented. Dysplasia of the oral cavity at times can also express a lichenoid histology, which may mask the potentially cancerous component. Proliferative verrucous leukoplakia, an unusual clinical disease, mimics oral lichen planus clinically and requires careful correlation of the clinical and pathologic features. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=5402059 Sun, 13 Nov 2011 17:11:53 +0100 5402059 http://www.medworm.com/index.php?rid=5402058&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918111001851%2Fabstract%3Frss%3Dyes The spectrum of possible diagnoses posed by the mingling of diverse tissue types present in the region of the head and neck can be challenging for all involved in the daily practice of surgical pathology. The purpose of this issue is not to cover every aspect of head and neck pathology but rather to have well recognized experts provide a foundation for diagnosis of critical entities in this region. Articles in this issue focus on aspects of interpretation that can be especially vexing in the head and neck, including salivary gland lesions, craniofacial bone lesions, odontogenic lesions, lichenoid lesions of oral mucosa, sinonasal tract, oral cavity and oropharynx, and larynx and hypopharynx. The articles are designed to offer a practical reference for the everyday interpretation of biopsie... Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=5402058 Sun, 13 Nov 2011 17:11:53 +0100 5402058 http://www.medworm.com/index.php?rid=5402057&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918111002558%2Fabstract%3Frss%3Dyes (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=5402057 Sun, 13 Nov 2011 17:11:53 +0100 5402057 http://www.medworm.com/index.php?rid=5402056&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918111002546%2Fabstract%3Frss%3Dyes (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=5402056 Sun, 13 Nov 2011 17:11:53 +0100 5402056 http://www.medworm.com/index.php?rid=5402055&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918111002534%2Fabstract%3Frss%3Dyes (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=5402055 Sun, 13 Nov 2011 17:11:53 +0100 5402055 http://www.medworm.com/index.php?rid=5317349&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918111001814%2Fabstract%3Frss%3Dyes (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=5317349 Thu, 01 Sep 2011 04:00:00 +0100 5317349 http://www.medworm.com/index.php?rid=5317348&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918111001693%2Fabstract%3Frss%3Dyes This article summarizes the clinical, pathologic, and molecular findings of the main liposarcoma subtypes. Special attention to the differential diagnosis and difficulties the pathologist may face when interpreting these lesions is discussed. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=5317348 Thu, 01 Sep 2011 04:00:00 +0100 5317348 http://www.medworm.com/index.php?rid=5317347&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918111001681%2Fabstract%3Frss%3Dyes This article reviews the most common and characteristic mesenchymal lesions found in the gastrointestinal tract and intraabdominal location in a pattern-based approach: spindle and epithelioid tumors (gastrointestinal stromal tumor, schwannoma, glomus tumor, leiomyoma and leiomyosarcoma, inflammatory fibroid polyp, perineurioma, melanoma, calcifying fibrous tumor, sclerosing mesenteritis, mesenteric fibromatosis, and inflammatory myofibroblastic tumor), and clear and granular tumors (clear cell sarcoma, granular cell tumor, gangliocytic paraganglioma, and ganglioneuroma). Information includes gross and histologic features, diagnosis and differential diagnosis, and histologic and other diagnostic techniques, including immunohistochemistry related to projected patient outcome, along with pro... Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=5317347 Thu, 01 Sep 2011 04:00:00 +0100 5317347 http://www.medworm.com/index.php?rid=5317346&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918111001668%2Fabstract%3Frss%3Dyes Abstract: Many neoplasms of the soft tissues feature giant cells, but this article covers entities in which giant cells are a striking feature. Specifically, we consider tenosynovial giant cell tumor (localized and diffuse types; giant cell tumor of tendon sheath, and pigmented villonodular tenosynovitis), reticulohistiocytoma, juvenile xanthogranuloma, giant cell fibroblastoma (a variant form of dermatofibrosarcoma protuberans), giant cell angiofibroma (which is essentially a giant cell—rich form of solitary fibrous tumor), and phosphaturic mesenchymal tumor. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=5317346 Thu, 01 Sep 2011 04:00:00 +0100 5317346 http://www.medworm.com/index.php?rid=5317345&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918111001656%2Fabstract%3Frss%3Dyes Abstract: Epithelioid variants have been described for most mesenchymal tumors, including leiomyosarcoma, pleomorphic liposarcoma, epithelioid fibrous histiocytoma, and myxofibrosarcoma. Soft tissue tumors that commonly show epithelioid morphology include epithelioid vascular lesions, epithelioid sarcoma, sclerosing epithelioid fibrosarcoma, and epithelioid malignant peripheral nerve sheath tumor. Many of the entities described in this review were originally described as “simulating carcinoma” or “often mistaken for carcinoma” and this pitfall should be considered when evaluating epithelioid lesions in soft tissue. Many epithelioid soft tissue tumors express epithelial antigens to a varying degree and an immunohistochemical panel is essential for correct classification. (Source: Su... Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=5317345 Thu, 01 Sep 2011 04:00:00 +0100 5317345 http://www.medworm.com/index.php?rid=5317344&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS187591811100170X%2Fabstract%3Frss%3Dyes Abstract: Myxoid tumors of soft tissue constitute a heterogeneous group of neoplasms characterized by the presence of a myxoid stromal matrix, which appears on H&E as an amorphous material and may be confused with edema. Superficial myxoid lesions in general are benign and deep ones are malignant. Grossly, they have a variable gelatinous quality and overlapping histologic features that may present diagnostic difficulties for pathologists. Most are sporadic neoplasms, with only a small percentage arising in patients with hereditary disorders. Discussed are key features of classic myxoid lesions, histologic features, characteristic clinical presentations, immunohistochemical patterns, cytogenetic analysis, and differential diagnosis. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=5317344 Thu, 01 Sep 2011 04:00:00 +0100 5317344 http://www.medworm.com/index.php?rid=5317343&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918111001644%2Fabstract%3Frss%3Dyes This article presents an overview of soft tissue tumors that have a plexiform histomorphology. The more commonly encountered entities, including plexiform fibrohistiocytic tumor, cellular neurothekeoma, dermal nerve sheath myxoma, plexiform schwannoma, and plexiform neurofibroma, are discussed in detail, and other tumors are noted. Information on clinical features, microscopic findings, ancillary studies, differential diagnosis, and prognosis is provided for each entity. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=5317343 Thu, 01 Sep 2011 04:00:00 +0100 5317343 http://www.medworm.com/index.php?rid=5317342&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS187591811100167X%2Fabstract%3Frss%3Dyes Abstract: Primitive round cell neoplasms (small round cell tumors) of soft tissue are a diverse group of malignant tumors composed of monotonous undifferentiated cells with high nuclear-cytoplasmic ratio. Many occur more frequently, although not exclusively, in childhood. As tumors with primitive round cell morphology are seen in virtually every basic tumor category, the diagnosis of small round cell neoplasms requires the use of ancillary diagnostic techniques: immunohistochemistry and often molecular genetics. The principal tumors in this group include Ewing sarcoma/primitive neuroectodermal tumor, desmoplastic small round cell tumor, alveolar rhabdomyosarcoma, poorly differentiated synovial sarcoma, neuroblastoma, and ganglioneuroblastoma. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=5317342 Thu, 01 Sep 2011 04:00:00 +0100 5317342 http://www.medworm.com/index.php?rid=5317341&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918111001632%2Fabstract%3Frss%3Dyes Abstract: Clear cell lesions of soft tissue include varying morphologic patterns and a range of clinical behaviors and prognoses. Benign lesions include perivascular epithelioid cell tumors, clear cell fibrous papule, and distinctive dermal clear cell mesenchymal tumor; malignant tumors include clear cell sarcoma, liposarcoma, and rare malignant perivascular epithelioid cell tumors. Clear cell variants of other benign and malignant soft tissue tumors include fibrous histiocytoma, atypical fibroxanthoma, myoepithelioma, leiomyoma and leiomyosarcoma, and rhabdomyosarcoma. Metastatic clear cell tumors, including renal cell carcinoma and adrenal cortical carcinoma, should be considered in the differential diagnosis and excluded through clinical history, imaging studies, and immunohistochemical... Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=5317341 Thu, 01 Sep 2011 04:00:00 +0100 5317341 http://www.medworm.com/index.php?rid=5317340&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918111001620%2Fabstract%3Frss%3Dyes This article presents an overview of the diagnostic categories of benign and malignant nerve sheath tumors, including neuroma, neurofibroma, nerve sheath myxoma, perineurioma, schwannoma, and malignant peripheral nerve sheath tumor. The discussion emphasizes histologic patterns; ancillary studies, such as immunohistochemistry; and differential diagnoses. The information is of value to practicing pathologists in both community and academic settings. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=5317340 Thu, 01 Sep 2011 04:00:00 +0100 5317340 http://www.medworm.com/index.php?rid=5317339&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918111001619%2Fabstract%3Frss%3Dyes Abstract: The authors address a group of loosely associated, characteristically benign soft tissue neoplasms that exhibit partial myoid differentiation. The entities share similarities in morphology and in nomenclature that have historically created confusion. The authors attempt to clarify the distinct architectural patterns and the corresponding immunophenotypic and ultrastructural features that distinguish myofibroma, myopericytoma, myoepithelioma, and myofibroblastoma. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=5317339 Thu, 01 Sep 2011 04:00:00 +0100 5317339 http://www.medworm.com/index.php?rid=5317338&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918111001607%2Fabstract%3Frss%3Dyes Abstract: Information is presented on the pathology of spindle cell sarcomas. Synovial sarcoma, malignant peripheral nerve sheath tumor, fibrosarcoma, inflammatory myofibroblastic tumor, low-grade myofibrosarcoma, leiomyosarcoma, spindle cell rhabdomyosarcoma, and endothelial neoplasms are discussed in terms of an overview of the tumor, microscopic and gross features, diagnostic techniques, genetic markers, differential diagnosis, clinical details, and prognosis. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=5317338 Thu, 01 Sep 2011 04:00:00 +0100 5317338 http://www.medworm.com/index.php?rid=5317337&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918111001590%2Fabstract%3Frss%3Dyes Abstract: Soft tissue pathology is one of the most challenging areas of diagnostic pathology, not only because of the morphologic diversity of such lesions, but also because of their rarity and pathologists' subsequent lack of exposure to these tumors. Many lesions mimic malignant mesenchymal neoplasms, collectively referred to as “pseudosarcomas.” The list of proliferations that can simulate a sarcoma is extensive and heterogeneous. This review addresses malignant, nonmesenchymal neoplasms; mesenchymal neoplasms that histologically mimic sarcomas but are benign; and benign reactive soft tissue lesions that are neither neoplastic nor malignant, but have worrisome clinical and/or morphologic features. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=5317337 Thu, 01 Sep 2011 04:00:00 +0100 5317337 http://www.medworm.com/index.php?rid=5317336&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918111001711%2Fabstract%3Frss%3Dyes Over 150 types of soft tissue tumors are well-described in the medical literature. They are classified according to lines of differentiation by the World Health Organization and can be confusing to separate. Most authors offer material categorized by line of differentiation, whereas pathologists tend to diagnose based on histologic pattern. As such, in daily practice, we tend to note whether a tumor is, for example, myxoid or spindled as its key morphologic characteristic, and then form our differential diagnosis accordingly. Thus, we would consider intramuscular myxoma and myxoid liposarcoma for a deep myxoid lesion even though one is formally classified as an adipose tissue tumor, whereas the other is not known to have a certain line of differentiation. Although Drs Fisher, Thway, and I ... Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=5317336 Thu, 01 Sep 2011 04:00:00 +0100 5317336 http://www.medworm.com/index.php?rid=5317335&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918111001802%2Fabstract%3Frss%3Dyes (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=5317335 Thu, 01 Sep 2011 04:00:00 +0100 5317335 http://www.medworm.com/index.php?rid=5317334&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918111001796%2Fabstract%3Frss%3Dyes (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=5317334 Thu, 01 Sep 2011 04:00:00 +0100 5317334 http://www.medworm.com/index.php?rid=5317333&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918111001784%2Fabstract%3Frss%3Dyes (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=5317333 Thu, 01 Sep 2011 04:00:00 +0100 5317333 http://www.medworm.com/index.php?rid=4879664&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918111001097%2Fabstract%3Frss%3Dyes (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4879664 Tue, 31 May 2011 16:28:57 +0100 4879664 http://www.medworm.com/index.php?rid=4879663&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918111000985%2Fabstract%3Frss%3Dyes This article focuses on the most commonly encountered pancreatic lesions and the importance of correlation of cytologic features with clinical, radiologic, and ancillary studies for accurate diagnosis. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4879663 Tue, 31 May 2011 16:28:57 +0100 4879663 http://www.medworm.com/index.php?rid=4879662&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918111000961%2Fabstract%3Frss%3Dyes Abstract: The pancreas is versatile in the diversity of disorders that it can exhibit. In this article, characteristics of disorders such as chronic, autoimmune, eosinophilic, hereditary, and infectious pancreatitis are described. With regard to autoimmune pancreatitis, the role of clinical evaluation, histologic examination, and IgG4 immunohistochemistry is discussed. The role of pancreatitis in the pathogenesis of diabetes is also mentioned. Some implications of pancreatitis are highlighted, including the neoplastic predisposition caused by inflammatory lesions of the pancreas. The goal of this article is to convey an appreciation of these disorders because their recognition can benefit patients tremendously, as inflammatory lesions of the pancreas can be mass-forming, giving rise to pse... Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4879662 Tue, 31 May 2011 16:28:57 +0100 4879662 http://www.medworm.com/index.php?rid=4879661&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS187591811100095X%2Fabstract%3Frss%3Dyes Abstract: Pancreatic neuroendocrine tumors (Pan-NETs) are the second most common epithelial neoplasm of the pancreas after ductal adenocarcinoma. They can be clinically defined as functional, nonfunctional, and hereditary. This review addresses typical and atypical pathologic features of Pan-NETs, with a focus on practical issues involved in differential diagnosis, immunohistochemical work-up, intraoperative frozen section interpretation, sources of diagnostic errors, and classification. The diagnosis of a Pan-NET requires analysis of all available clinical and radiographic information and pathologic characteristics of the tumor, and it is crucial to understand the clinical impact of the pathologic interpretation. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4879661 Tue, 31 May 2011 16:28:57 +0100 4879661 http://www.medworm.com/index.php?rid=4879660&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918111000936%2Fabstract%3Frss%3Dyes Abstract: This review describes the clinicopathologic characteristics, differential diagnosis, and biologic behavior of exocrine pancreatic tumors of predominantly nonductal differentiation: acinar cell carcinoma, pancreatoblastoma, and solid-pseudopapillary neoplasm. Patients usually present with a well-demarcated, large, soft, solitary mass with expansile, rather than infiltrative, growth pattern. Cystic change is common. Histologically, the tumors usually reveal at least a focal solid, cellular appearance composed of uniform, monomorphic epithelial cells. However, each type has characteristic clinicopathological features. The immunohistochemical labeling profile of pancreatoblastoma parallels the multiple lines of differentiation. These tumors are capable of producing metastases; howeve... Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4879660 Tue, 31 May 2011 16:28:57 +0100 4879660 http://www.medworm.com/index.php?rid=4879659&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918111000948%2Fabstract%3Frss%3Dyes This article reviews the surgical pathology of nonmucinous cysts. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4879659 Tue, 31 May 2011 16:28:57 +0100 4879659 http://www.medworm.com/index.php?rid=4879658&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918111001000%2Fabstract%3Frss%3Dyes This article presents the clinicopathologic characteristics and differential features of pancreatic mucinous tumors. These tumors, which correspond to the most frequent cystic neoplasms, are encountered with increasing frequency. They comprise the mucinous cystic neoplasms and the intraductal papillary mucinous neoplasms. These tumors are known to progress from dysplasia to invasive carcinoma. Thus, it appears important to distinguish them from other cystic neoplasms and non-neoplastic cysts. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4879658 Tue, 31 May 2011 16:28:57 +0100 4879658 http://www.medworm.com/index.php?rid=4879657&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918111000973%2Fabstract%3Frss%3Dyes Abstract: Pancreatic intraepithelial neoplasias (PanINs) are microscopic lesions of the pancreas. Traditionally viewed as a benign metaplasia of small ducts, evidence suggests that PanINs are neoplastic and that some PanINs progress to invasive ductal adenocarcinoma. The primary diagnostic challenge is distinguishing PanINs from other lesions, including invasive ductal adenocarcinoma, intraductal papillary mucinous neoplasm, and cancerization of benign ducts. PanINs are the most common of the pancreatic cancer precursor lesions, yet they remain poorly understood and are so small that they are almost clinically undetectable. Further study is required to define the role of PanINs in the carcinogenesis and early detection of pancreatic cancer. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4879657 Tue, 31 May 2011 16:28:57 +0100 4879657 http://www.medworm.com/index.php?rid=4879656&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918111000997%2Fabstract%3Frss%3Dyes This article provides a guide for pathologic evaluation of PDAC specimens with the macroscopic and microscopic features of common PDAC and its variants and discusses the differential diagnosis and morphologic and immunophenotypical prognostic parameters. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4879656 Tue, 31 May 2011 16:28:57 +0100 4879656 http://www.medworm.com/index.php?rid=4879655&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918111001012%2Fabstract%3Frss%3Dyes The saga of pancreas began with the ancient Greeks at the coastal bays of the Aegean Sea, now a part of modern Turkey, where the term pancreas was coined (the Greek root of the word is based on the cow pancreas being a gourmet food, “sweetbread”). Its first anatomic dissection was performed (without any understanding of its associations), and the first speculations on its nature and significance (it was believed to be a mere cushion for the vessels lying behind it) had been made. It may be an interesting coincidence for the readers to note that both guest editors of this issue were originally from the Aegean region, too. Much has been learned about this enigmatic organ since the days of Galen, but at the same time, undoubtedly much remains to be unraveled. We hope that we were true to ... Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4879655 Tue, 31 May 2011 16:28:56 +0100 4879655 http://www.medworm.com/index.php?rid=4879654&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918111001085%2Fabstract%3Frss%3Dyes (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4879654 Tue, 31 May 2011 16:28:56 +0100 4879654 http://www.medworm.com/index.php?rid=4879653&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918111001073%2Fabstract%3Frss%3Dyes (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4879653 Tue, 31 May 2011 16:28:56 +0100 4879653 http://www.medworm.com/index.php?rid=4879652&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918111001061%2Fabstract%3Frss%3Dyes (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4879652 Tue, 31 May 2011 16:28:56 +0100 4879652 http://www.medworm.com/index.php?rid=4585150&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918111000092%2Fabstract%3Frss%3Dyes (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4585150 Tue, 01 Mar 2011 00:00:00 +0100 4585150 http://www.medworm.com/index.php?rid=4585149&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110000048%2Fabstract%3Frss%3Dyes Abstract: Approximately 10% of ovarian cancers are associated with inherited germline mutations, most commonly of the BRCA1 or BRCA2 genes. The majority of BRCA1 and BRCA2 cancers are high-grade serous carcinomas diagnosed at an advanced stage, and there are as yet no histologic features that distinguish these tumors from sporadic serous cancers. Many women identified as being at high genetic risk undergo prophylactic salpingo-oophorectomy, and careful histopathological examination of these specimens may identify occult carcinoma, frequently in the distal fallopian tube. In addition, serous cancer precursors, including tubal intraepithelial carcinoma, have been increasingly recognized in distal and fimbrial epithelium. Little has been documented to date of the histopathological features of... Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4585149 Tue, 01 Mar 2011 00:00:00 +0100 4585149 http://www.medworm.com/index.php?rid=4585148&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS187591811000262X%2Fabstract%3Frss%3Dyes Abstract: This review covers the group of relatively uncommon nonserous ovarian epithelial tumors. The authors focus on the group's distinctiveness from the much more common serous tumors and show the similarities across entities. Diagnostic criteria that separate the different entities are currently being debated. Particular problems include the reproducible diagnosis of high-grade endometrioid, transitional cell, mixed epithelial and undifferentiated carcinomas. Furthermore, despite recognition that most malignant mucinous tumors involving ovary represent metastases from extraovarian primary sites, many misdiagnoses still occur. The authors discuss their rationale behind their opinions about these problematic topics. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4585148 Tue, 01 Mar 2011 00:00:00 +0100 4585148 http://www.medworm.com/index.php?rid=4585147&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110002540%2Fabstract%3Frss%3Dyes Abstract: The focus of this review is high-grade serous carcinoma (HGSC); for the purposes of this review, the term “pelvic SC” is used for HGSC that could be considered, based on historical definitions, to have arisen from ovary, fallopian tube, or peritoneum. These assignments of primary site are arbitrary and there is evidence that the distal fallopian tube is the site of origin of many pelvic HGSCs. The diagnosis of HGSC can be made readily based on routine histomorphologic examination in most cases; however, a variety of neoplasms can resemble HGSC. Thus, we review the key features of pelvic SC, current concepts of its pathogenesis, histopathological diagnostic criteria, discuss differential diagnosis, and review diagnostic ancillary studies that can be used in practice. (Source: ... Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4585147 Tue, 01 Mar 2011 00:00:00 +0100 4585147 http://www.medworm.com/index.php?rid=4585146&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110002618%2Fabstract%3Frss%3Dyes Abstract: This review focuses on recent advances in the area of low-grade ovarian serous neoplasia with emphasis on key diagnostic criteria, differential diagnosis, and disease classification based on current understanding of low-grade serous carcinogenesis. Despite considerable controversy surrounding serous tumors of low malignant potential (S-LMP) or borderline tumors, there have been great strides in our understanding of the serous group of borderline and malignant pelvic epithelial neoplasms in the past decade. Most S-LMP have a favorable prognosis, but recurrences and progression to carcinoma occur, sometimes following a protracted clinical course. Pathologic risk factors vary, but the extraovarian implant status is the most important predictor for progressive disease. Progression of... Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4585146 Tue, 01 Mar 2011 00:00:00 +0100 4585146 http://www.medworm.com/index.php?rid=4585145&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110002606%2Fabstract%3Frss%3Dyes Abstract: In this review, ovarian metastatic carcinomas from various sites, as well as other neoplasms secondarily involving the ovary, are discussed. As well as describing the morphology, the value of immunohistochemistry in distinguishing between primary and metastatic neoplasms in the ovary is discussed. While immunohistochemistry has a valuable role to play and is paramount in some cases, the results should be interpreted with caution and with regard to the clinical picture and gross and microscopic pathologic findings. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4585145 Tue, 01 Mar 2011 00:00:00 +0100 4585145 http://www.medworm.com/index.php?rid=4585144&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS187591811000259X%2Fabstract%3Frss%3Dyes Abstract: This content presents a review of molecular pathology of ovarian cancer. The authors present key molecular features for high-grade and low-grade serous carcinomas, endometrioid carcinomas, clear cell carcinomas, and mucinous carcinomas. Cell lineage, mutation and gene expression, pathway alterations, risk factors, prognostic markers, and treatment targets are discussed. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4585144 Tue, 01 Mar 2011 00:00:00 +0100 4585144 http://www.medworm.com/index.php?rid=4585143&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110002539%2Fabstract%3Frss%3Dyes Abstract: Ovarian, fallopian tube and peritoneal carcinomas make up the deadliest group of malignancies of the female genital tract. Ovarian carcinoma is the second most common malignancy of the female reproductive tract in developed countries and the sixth most common cancer diagnosed in women in the United States. While signs and symptoms of ovarian carcinoma related to the mass-effect of advanced disease are relatively common, no reliable signs or symptoms are seen in patients with early ovarian carcinoma. The diagnosis can only be made by surgical removal and pathologic evaluation of a suspicious mass. The authors present an overview of the disease and discussions of genetic predisposition, prevention, screening, and diagnosis of ovarian, fallopian tube and primary peritoneal carcinoma... Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4585143 Tue, 01 Mar 2011 00:00:00 +0100 4585143 http://www.medworm.com/index.php?rid=4585142&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110002527%2Fabstract%3Frss%3Dyes Abstract: Women with Lynch syndrome are at considerable risk for developing endometrial carcinoma, but current screening guidelines for detection of Lynch syndrome focus almost exclusively on colorectal carcinoma. Lynch syndrome associated colorectal and endometrial carcinomas have some important differences with implications for screening strategies. These differences are discussed in this review, along with the most effective screening criteria and testing methods for detection of Lynch syndrome in endometrial carcinoma patients. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4585142 Tue, 01 Mar 2011 00:00:00 +0100 4585142 http://www.medworm.com/index.php?rid=4585141&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110002588%2Fabstract%3Frss%3Dyes Abstract: High-grade endometrial carcinomas are a heterogeneous group of clinically aggressive tumors. They include FIGO grade 3 endometrioid carcinoma, serous carcinoma, clear cell carcinoma, undifferentiated carcinoma, and malignant mixed Müllerian tumor (MMMT). Epidemiologic, genetic, biologic prognostic and morphologic differences between these entities are striking in prototypic cases, yet substantial overlap exists and diagnostic criteria and therapeutic approaches that account for the group's diversity are currently insufficient. FIGO grade 3 endometrioid carcinoma demonstrates solid, trabecular or nested growth and may resemble poorly differentiated squamous cell carcinoma. Endometrioid glandular differentiation is usually focally present. Serous carcinoma usually displays papilla... Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4585141 Tue, 01 Mar 2011 00:00:00 +0100 4585141 http://www.medworm.com/index.php?rid=4585140&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110002576%2Fabstract%3Frss%3Dyes This article presents evidence-based histologic criteria for atypical endometrial hyperplasia and low grade endometrial carcinoma (both FIGO grade 1 and 2) with emphasis on common and not so common histologic mimics. Grade 3 endometrioid carcinoma is discussed in the Oliva and Soslow article in this publication. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4585140 Tue, 01 Mar 2011 00:00:00 +0100 4585140 http://www.medworm.com/index.php?rid=4585139&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110002515%2Fabstract%3Frss%3Dyes Abstract: In the developed world, endometrial carcinoma is the most common malignant tumor of the female gynecologic tract. Numerous epidemiologic studies indicate that exposure to unopposed estrogen is a significant risk factor for developing endometrial cancer, particularly endometrioid-type endometrial carcinoma; however, a number of other molecular pathways and mechanisms are also important in endometrial cancer. In this review, the authors highlight some of the more interesting molecular pathways in endometrial cancer, such as the PTEN/PI3K/AKT pathway, microsatellite instability, and molecular mediators of epithelial-to-mesenchymal transition. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4585139 Tue, 01 Mar 2011 00:00:00 +0100 4585139 http://www.medworm.com/index.php?rid=4585138&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110000036%2Fabstract%3Frss%3Dyes This article focuses on the most important neoplastic epithelial lesions of the uterus, endometrial hyperplasia and carcinoma. The primary management of hyperplastic lesions and carcinoma is often surgical but nonsurgical options are possible for both, depending on specific patients and tumor characteristics. Many controversies still exist regarding the optimal medical and surgical treatments of hyperplasias and carcinomas of the endometrium. There is a need to more accurately select patients for lymph node sampling or dissection. The role of adjuvant therapies for endometrial carcinomas is still under investigation. This review covers current understanding in the diagnosis and clinical management of endometrial hyperplasias and carcinomas. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4585138 Tue, 01 Mar 2011 00:00:00 +0100 4585138 http://www.medworm.com/index.php?rid=4585137&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110000024%2Fabstract%3Frss%3Dyes Abstract: Carcinoma of the vulva is an uncommon malignant neoplasm (approximately one-fifth as frequent as cervical cancer) and represents 4% of all genital cancers in women. Approximately two-thirds of cases occur in women older than 60 years, and squamous cell carcinoma is the most common histologic type. Several different subtypes of squamous cell carcinoma have been described in the vulva; however, in terms of etiology, pathogenesis, and histologic features, most carcinomas belong to one of two categories: keratinizing squamous cell carcinomas associated with chronic inflammatory skin disorders, and basaloid or warty carcinomas related to infection with high oncogenic risk human papillomaviruses. Glandular neoplasms of the vulva arise from the vulvar apocrine sweat glands (papillary hi... Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4585137 Tue, 01 Mar 2011 00:00:00 +0100 4585137 http://www.medworm.com/index.php?rid=4585136&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110002564%2Fabstract%3Frss%3Dyes Abstract: This review presents a discussion of the gross and microscopic features, diagnosis, differential diagnosis, and prognosis of neoplastic lesions of the cervix. Biomarkers are discussed for each entity presented – cervical intraepithelial neoplasia, squamous carcinoma, glandular neoplasms, adenocarcinoma in situ, adenosquamous carcinoma, and others. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4585136 Tue, 01 Mar 2011 00:00:00 +0100 4585136 http://www.medworm.com/index.php?rid=4585135&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110002552%2Fabstract%3Frss%3Dyes Abstract: This content presents pathology of the cervix and vulva – its diagnosis, staging, treatment, and prognosis. The authors distinguish between the clinical staging of cervical cancer and the surgical staging of vulvar cancer and note advances in surgical, medical, and radiation oncology in the treatment of both cervical and vulvar carcinoma that allow for individualization of patient treatment resulting in improved oncologic outcomes and improved quality of life. Treatment algorithms are presented based on the varying stages at which the cancer is diagnosed. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4585135 Tue, 01 Mar 2011 00:00:00 +0100 4585135 http://www.medworm.com/index.php?rid=4585134&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110002631%2Fabstract%3Frss%3Dyes Editing this publication was a great joy despite the challenges. It presented many wonderful opportunities: working with compelling subject matter; collaborating with some of the finest pathologists in the world; mentoring younger pathologists (who are also among the finest pathologists around); learning a great deal about gynecologic oncology and pathology; honing editorial skills; and creating work whose scope is broad enough to spark interest in investigative pursuits and sufficiently specific to be of practical value. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4585134 Tue, 01 Mar 2011 00:00:00 +0100 4585134 http://www.medworm.com/index.php?rid=4585133&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918111000080%2Fabstract%3Frss%3Dyes (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4585133 Tue, 01 Mar 2011 00:00:00 +0100 4585133 http://www.medworm.com/index.php?rid=4585132&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918111000079%2Fabstract%3Frss%3Dyes (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4585132 Tue, 01 Mar 2011 00:00:00 +0100 4585132 http://www.medworm.com/index.php?rid=4585131&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918111000067%2Fabstract%3Frss%3Dyes (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4585131 Tue, 01 Mar 2011 00:00:00 +0100 4585131 http://www.medworm.com/index.php?rid=4222656&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110002059%2Fabstract%3Frss%3Dyes (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4222656 Wed, 01 Dec 2010 00:00:00 +0100 4222656 http://www.medworm.com/index.php?rid=4222655&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110001273%2Fabstract%3Frss%3Dyes Abstract: An unusual disease, mastocytosis challenges the pathologist with a variety of morphologic appearances and heterogeneous clinical presentations ranging from skin manifestations (pruritus, urticaria, dermatographism) to systemic signs and symptoms indicative of mast cell mediator release, including flushing, hypotension, headache, and anaphylaxis among others. In this article, we focus on recognizing the cytology, histopathology, clinical features, and prognostic implications of systemic mastocytosis, a clonal and neoplastic mast cell proliferation infiltrating extracutaneous organ(s) with or without skin involvement. Diagnostic pitfalls are reviewed with ancillary studies to help unmask the mast cell and exclude morphologic mimics. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4222655 Wed, 01 Dec 2010 00:00:00 +0100 4222655 http://www.medworm.com/index.php?rid=4222654&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110001327%2Fabstract%3Frss%3Dyes This article reviews the features of dendritic cells (DCs) of myeloid-derived, plasmacytoid, and follicle-associated types and tumors of these cells, as well as myeloid sarcoma. The morphologic and immunophenotypic features in this group of neoplasms is featured, including mature neoplasms such as Langerhans cell histiocytosis, its malignant counterpart Langerhans cell sarcoma, and S100-negative histiocytic proliferations. More immature or precursor malignancies in this group include myeloid and monocytic leukemias presenting in extramedullary tissues as well as the newly codified blastic plasmacytoid dendritic cell neoplasm. Although likely not related histogenetically to myeloid-derived DCs, mesenchymal-type lymph node tumors including follicular dendritic cell and fibroblastic reticulu... Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4222654 Wed, 01 Dec 2010 00:00:00 +0100 4222654 http://www.medworm.com/index.php?rid=4222653&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110001364%2Fabstract%3Frss%3Dyes Abstract: Acute myeloid leukemia (AML) with multilineage dysplasia was introduced in the 2001 World Health Organization (WHO) classification to encompass cases of AML characterized by myelodysplastic syndrome–like features. The 2008 WHO classification revised this group into a new category, AML with myelodysplasia-related changes (AML-MRC). The category now includes patients with at least 20% blasts in peripheral blood or bone marrow and any of the following: (1) AML arising from a previous MDS or mixed MDS/myeloproliferative neoplasm, (2) AML with a specific MDS-associated cytogenetic abnormality and/or (3) AML with multilineage dysplasia. Up to 48% of all patients with AML are encompassed within the AML-MRC subgroup. AML-MRC patients have worse prognosis compared with patients with AML... Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4222653 Wed, 01 Dec 2010 00:00:00 +0100 4222653 http://www.medworm.com/index.php?rid=4222652&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110001303%2Fabstract%3Frss%3Dyes Abstract: Sustained clinical cytopenia is a frequent laboratory finding in ambulatory and hospitalized patients. For pathologists and hematopathologists who examine the bone marrow (BM), a diagnosis of cytopenia secondary to an infiltrative BM process or acute leukemia can be readily established based on morphologic evaluation and flow cytometry immunophenotyping. However, it can be more challenging to establish a diagnosis of myelodysplastic syndrome (MDS). In this article, the practical approaches for establishing or excluding a diagnosis of MDS (especially low-grade MDS) in patients with clinical cytopenia are discussed along with the current diagnostic recommendations provided by the World Health Organization and the International Working Group for MDS. (Source: Surgical Pathology Clin... Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4222652 Wed, 01 Dec 2010 00:00:00 +0100 4222652 http://www.medworm.com/index.php?rid=4222651&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110001315%2Fabstract%3Frss%3Dyes Abstract: The evaluation of pediatric bone marrow poses specific challenges when compared with the general adult population. These challenges stem in part from the higher likelihood of congenital disorders with hematopoietic manifestations, some of which may give rise to hematologic malignancies. Familiarity with the spectrum of disorders seen in the pediatric age group allows for an appropriate and focused differential diagnosis. This review addresses the diagnostic workup of pediatric bone marrow samples, as directed by the peripheral blood and bone marrow findings in the context of the patient’s clinical history. Recommendations for the appropriate use of ancillary studies in various scenarios are provided. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4222651 Wed, 01 Dec 2010 00:00:00 +0100 4222651 http://www.medworm.com/index.php?rid=4222650&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110001297%2Fabstract%3Frss%3Dyes Abstract: The plasma cell neoplasms are malignancies of the most terminally differentiated cells in B-cell ontogeny and are usually associated with the production of a monoclonal immunoglobulin molecule or M protein. These malignancies include tumors whose clinical manifestations are directly attributable to the end-organ damage induced by the dysregulated proliferation of neoplastic plasma cells. In contrast, disorders, such as primary amyloidosis, have a paradoxically low burden of neoplastic plasma cells, rendered highly pathogenic by the end-organ damage induced by deposition of the secreted paraprotein. In this article, discussion focuses on plasma cell myeloma. The molecular pathogenesis of plasma cell myeloma is reviewed and the diagnosis of the plasma cell neoplasms discussed. (Sou... Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4222650 Wed, 01 Dec 2010 00:00:00 +0100 4222650 http://www.medworm.com/index.php?rid=4222649&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110001340%2Fabstract%3Frss%3Dyes Abstract: Burkitt lymphoma (BL) is an aggressive B-cell neoplasm with an extremely short doubling time that mainly affects children and young adults. Despite having several characteristic features, none is entirely specific for BL and the differential diagnosis may include diffuse large B-cell lymphoma (DLBCL), B lymphoblastic leukemia/lymphoma, and B-cell lymphoma unclassifiable with features intermediate between DLBCL and BL. We outline a practical approach to establish a diagnosis of BL and distinguish it from other high-grade B-cell malignancies. We pay particular attention to B-cell lymphomas with features intermediate between DLBCL and BL, a new diagnostic category in the 2008 World Health Organization classification system that provides a framework for categorizing challenging cases... Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4222649 Wed, 01 Dec 2010 00:00:00 +0100 4222649 http://www.medworm.com/index.php?rid=4222648&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110001261%2Fabstract%3Frss%3Dyes This article reviews the spectrum of Epstein-Barr virus and Kaposi sarcoma herpesvirus (KSHV/HHV-8)-associated B-cell lymphoid proliferations, their pathologic features and clinical presentation, diagnostic criteria, and pathogenetic aspects. Emphasis is on the differential diagnosis issues and difficulties that the pathologist may face for the correct identification and interpretation of these lesions. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4222648 Wed, 01 Dec 2010 00:00:00 +0100 4222648 http://www.medworm.com/index.php?rid=4222647&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS187591811000125X%2Fabstract%3Frss%3Dyes Abstract: Lymph node-based peripheral T-cell lymphomas are rare and exhibit a morphologic spectrum that overlaps with reactive lymphoid hyperplasia, B-cell lymphomas, and Hodgkin lymphoma, presenting a diagnostic challenge. This review focuses on the major categories of lymph node-based peripheral T-cell lymphomas recognized by the 2008 World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues. Diagnostic strategies for approaching T-cell neoplasms using a combined clinical, morphologic, immunophenotypic, and genetic approach are presented. Practical information to aid in distinguishing peripheral T-cell lymphomas from other hematologic malignancies and benign conditions is provided. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4222647 Wed, 01 Dec 2010 00:00:00 +0100 4222647 http://www.medworm.com/index.php?rid=4222646&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110001285%2Fabstract%3Frss%3Dyes This article discusses the diagnostic approach to splenic-based lymphoproliferative disorders in routine practice and describes the clinicopathologic features of lymphoid neoplasms that characteristically present in the spleen. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4222646 Wed, 01 Dec 2010 00:00:00 +0100 4222646 http://www.medworm.com/index.php?rid=4222645&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110001339%2Fabstract%3Frss%3Dyes Abstract: Chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL), and monoclonal B-cell lymphocytosis (MBL) are clonal proliferations of small, mature B cells. CLL and SLL are considered neoplastic, although they are indolent and many patients with these lymphomas never require treatment. Most MBL cases share immunophenotypic and genetic features with CLL and SLL but have a small burden of clonal cells. This review focuses on the pathologic features of CLL, SLL, and MBL and their differential diagnoses. Guidelines are provided to separate the entities from one another and to avoid pitfalls in distinguishing these entities from other lymphomas and from reactive lymphoid proliferations. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4222645 Wed, 01 Dec 2010 00:00:00 +0100 4222645 http://www.medworm.com/index.php?rid=4222644&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110001133%2Fabstract%3Frss%3Dyes Abstract: Follicular lymphoma is a relatively common B-cell lymphoma composed of follicle center B lymphocytes. Follicular lymphomas occurring in the pediatric population and in some extranodal sites exhibit particular clinicopathologic features and clinical behavior that are often distinct from adult nodal follicular lymphoma. A type of “in-situ” follicular lymphoma presents as intrafollicular neoplastic cells in a background of architecturally normal lymphoid tissue and may be difficult to recognize in routine sections. Accurate recognition of the morphologic variants and clinicopathologic subtypes of follicular lymphoma is important to avoid confusing them with other lymphomas and reactive processes; in addition, some of these subtypes of follicular lymphoma display unusually indole... Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4222644 Wed, 01 Dec 2010 00:00:00 +0100 4222644 http://www.medworm.com/index.php?rid=4222643&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110001352%2Fabstract%3Frss%3Dyes The field of hematopathology is an ever-changing discipline: as our clinical colleagues develop and implement increasingly sophisticated therapies, we pathologists are constantly refining our ability to effectively diagnose the diseases they are treating. Many current therapies aim to target oncogenic pathways deregulated in particular neoplasms, requiring us to interrogate diseases with tools that tease out these specific pathways. While these ancillary tools often inform us about the tumor biologies, they add to the large amounts of (sometimes contradictory) data that we must digest and synthesize in each case. The goal of this issue is to present the current state-of-the-art diagnostic approaches in several particular areas of hematopathology. I have chosen areas that my colleagues and ... Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4222643 Wed, 01 Dec 2010 00:00:00 +0100 4222643 http://www.medworm.com/index.php?rid=4222642&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110002047%2Fabstract%3Frss%3Dyes (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4222642 Wed, 01 Dec 2010 00:00:00 +0100 4222642 http://www.medworm.com/index.php?rid=4222641&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110002035%2Fabstract%3Frss%3Dyes (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4222641 Wed, 01 Dec 2010 00:00:00 +0100 4222641 http://www.medworm.com/index.php?rid=4222640&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110002023%2Fabstract%3Frss%3Dyes (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4222640 Wed, 01 Dec 2010 00:00:00 +0100 4222640 http://www.medworm.com/index.php?rid=4092346&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110001212%2Fabstract%3Frss%3Dyes (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4092346 Tue, 31 Aug 2010 23:00:00 +0100 4092346 http://www.medworm.com/index.php?rid=4092345&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110000462%2Fabstract%3Frss%3Dyes This article focuses on the findings seen on biopsy, usually of the transplanted organ, and also of other sites affected by post-transplant complications. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4092345 Tue, 31 Aug 2010 23:00:00 +0100 4092345 http://www.medworm.com/index.php?rid=4092344&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110000632%2Fabstract%3Frss%3Dyes Abstract: Brain tumors represent a significant group of tumors seen in the pediatric population. Intraoperative consultation represents a critical and integral component of the management of these tumors. Since the prevalence, frequency, and location of the different histologic types of brain tumors vary significantly between children and adults, it is reasonable to expect that diagnoses entertained during intraoperative consultation will also differ, influencing the aggressiveness of surgical resection and course of management. It is, therefore, imperative for surgical pathologists responsible for pediatric patients to become familiar with these entities and the diagnostic challenges they pose during the course of surgery. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4092344 Tue, 31 Aug 2010 23:00:00 +0100 4092344 http://www.medworm.com/index.php?rid=4092343&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110000310%2Fabstract%3Frss%3Dyes This article discusses algorithms that may aid pathologists in differential diagnosis of common inherited disorders of the liver, with emphasis on ancillary diagnostic tools and reference assays that are critical in establishing the diagnosis. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4092343 Tue, 31 Aug 2010 23:00:00 +0100 4092343 http://www.medworm.com/index.php?rid=4092342&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110000309%2Fabstract%3Frss%3Dyes Abstract: Varied intestinal neuromuscular pathologies are responsible for Hirschsprung disease and other forms of chronic pseudo-obstruction that are encountered in pediatrics. Pathologically distinct subtypes discussed in this review include aganglionosis, hypoganglionosis, neuronal intranuclear inclusion disease, ganglionitis, degenerative neuropathy, diffuse ganglioneuromatosis, neuronal dysplasia, malformations of the muscularis propria, degenerative leiomyopathy, leiomyositis, and mitochondriopathies. Emphasis is given to the histopathologic features that distinguish these conditions and their differential diagnoses. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4092342 Tue, 31 Aug 2010 23:00:00 +0100 4092342 http://www.medworm.com/index.php?rid=4092341&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110000449%2Fabstract%3Frss%3Dyes This article provides an overview of pediatric carcinoma as well as a detailed review of selected types of carcinoma that in particular can present diagnostic difficulty to the practicing pathologist and illustrate new and emerging concepts in pediatric carcinoma. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4092341 Tue, 31 Aug 2010 23:00:00 +0100 4092341 http://www.medworm.com/index.php?rid=4092340&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110000292%2Fabstract%3Frss%3Dyes This article discusses the clinical and pathologic features of myofibroblastic tumors in children, with special emphasis on differential diagnosis. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4092340 Tue, 31 Aug 2010 23:00:00 +0100 4092340 http://www.medworm.com/index.php?rid=4092339&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110000474%2Fabstract%3Frss%3Dyes Abstract: Renal cell carcinomas are rare in children, and they show significant differences in their histology and pathogenesis when compared with those common in adults. The most common subtypes seen preferentially in children are the translocation-associated tumors, papillary renal cell carcinoma, renal medullary carcinoma, and oncocytic renal cell carcinoma following neuroblastoma. The histologic diagnosis of renal cell carcinoma is made difficult by the considerable heterogeneity within and overlap between each of the above subtypes and by similarities to other pediatric renal neoplasms. While no effective therapies have yet been identified, there is considerable promise that the new Children’s Oncology Group protocol will provide knowledge that will guide the future therapy of these... Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4092339 Tue, 31 Aug 2010 23:00:00 +0100 4092339 http://www.medworm.com/index.php?rid=4092338&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110000267%2Fabstract%3Frss%3Dyes Abstract: Intestinal biopsies constitute an ever-increasing portion of the pathologist’s workload, accounting for nearly two-thirds of specimens accessioned yearly by the pathology department at The Children’s Hospital of Philadelphia. The widespread use of endoscopy and gastrointestinal biopsies in current clinical practice presents the pathologist with a diversity of intestinal mucosal appearances corresponding to disease states of variable clinical severity, requiring close collaboration between clinician and pathologist for optimal interpretation. Many of the entities resulting in severe diarrhea of infancy have been recognized only in the last several decades, and although rare, the study of these disorders, especially when combined with the powerful methods of present-day genetic... Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4092338 Tue, 31 Aug 2010 23:00:00 +0100 4092338 http://www.medworm.com/index.php?rid=4092337&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110000280%2Fabstract%3Frss%3Dyes Abstract: The term, disorders of sexual differentiation, broadly represents a disjunction between genotype and phenotype. Phenotype in turn can refer to external or internal genital development. Disorders of sexual differentiation are determined at conception insofar as (1) the abnormal genotype is the aberrant genetic product of fertilization at the chromosomal level or (2) the abnormal phenotype results from postfertilization errors in function at the gene level, somewhere along the pathway of transcription and translation. In either event, the error is genetic, whether or not sporadic or inherited, even if the pathways have yet to be fully elucidated for a given disorder. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4092337 Tue, 31 Aug 2010 23:00:00 +0100 4092337 http://www.medworm.com/index.php?rid=4092336&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110000279%2Fabstract%3Frss%3Dyes This article outlines key histologic features of pediatric small cell neoplasms and the algorithms that allow diagnostic confirmation and the initiation of appropriate therapy. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4092336 Tue, 31 Aug 2010 23:00:00 +0100 4092336 http://www.medworm.com/index.php?rid=4092335&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110000450%2Fabstract%3Frss%3Dyes This article describes the clinical characteristics, pathologic features, and differential diagnosis of challenging and recently described entities in pediatric lung disease. The specific entities discussed include alveolar capillary dysplasia, genetic disorders of surfactant metabolism, pulmonary interstitial glycogenosis, and neuroendocrine cell hyperplasia of infancy. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4092335 Tue, 31 Aug 2010 23:00:00 +0100 4092335 http://www.medworm.com/index.php?rid=4092334&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110000759%2Fabstract%3Frss%3Dyes Abstract: Pediatric vascular tumors and malformations, comprising a broad category of lesions often referred to as vascular anomalies, are a heterogenous group of clinicopathologically distinct entities. Pathologists, clinicians, and radiologists have traditionally lumped these lesions under the generic term, hemangioma, sometimes qualified by modifiers, such as capillary or cavernous. Advances in understanding underlying pathogenetic mechanisms support more specific classification and more specifically targeted therapies. Multidisciplinary consensus has moved toward a biologically based classification system and therapeutic approach for dealing with these lesions. This content focuses on the histologic, immunophenotypical, and clinical features that distinguish the major types of vascular... Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4092334 Tue, 31 Aug 2010 23:00:00 +0100 4092334 http://www.medworm.com/index.php?rid=4092333&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110000954%2Fabstract%3Frss%3Dyes Largely thanks to the genetic revolution, pediatric surgical pathology has been a rapidly evolving field in recent years. As a discipline, pediatric pathology can probably boast requiring the most arcane knowledge about the widest variety of lesions, necessitating a detailed knowledge of genetics and embryology as well as human anatomy and histology. These sciences intersect at the bench of the individual performing surgical pathology on childhood tissues. We have witnessed a gratifying growth in our knowledge of diverse lesions that create pediatric disease, many of which have been previously considered “idiopathic,” “syndromic,” or simply unexplained. However, with this growth has come a need for increasing knowledge of pediatric diseases for diagnosticians who interact with an i... Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4092333 Tue, 31 Aug 2010 23:00:00 +0100 4092333 http://www.medworm.com/index.php?rid=4092332&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110001200%2Fabstract%3Frss%3Dyes (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4092332 Tue, 31 Aug 2010 23:00:00 +0100 4092332 http://www.medworm.com/index.php?rid=4092331&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110001194%2Fabstract%3Frss%3Dyes (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4092331 Tue, 31 Aug 2010 23:00:00 +0100 4092331 http://www.medworm.com/index.php?rid=4092330&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110001182%2Fabstract%3Frss%3Dyes (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=4092330 Tue, 31 Aug 2010 23:00:00 +0100 4092330 http://www.medworm.com/index.php?rid=3874604&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110000711%2Fabstract%3Frss%3Dyes (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3874604 Mon, 31 May 2010 23:00:00 +0100 3874604 http://www.medworm.com/index.php?rid=3874603&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS187591811000019X%2Fabstract%3Frss%3Dyes Abstract: An estimated 150,000 individuals are diagnosed with colorectal carcinoma (CRC) each year, and approximately 50,000 will die from this disease, making CRC the third leading cause of cancer deaths in the United States. For this reason, an enormous amount of effort has been spent to understand the molecular pathogenesis of this disease and to develop screening tests and prognostic markers. In the last 10 years, there has been a revolution in the understanding of CRC due to the identification of multiple distinct molecular pathways. With the introduction of biologic agents that target particular subtypes of CRC, molecular analysis of CRC is becoming standard of care in surgical pathology. In this context, the authors first describe the multiple molecular pathways leading to CRC and t... Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3874603 Mon, 31 May 2010 23:00:00 +0100 3874603 http://www.medworm.com/index.php?rid=3874602&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110000164%2Fabstract%3Frss%3Dyes This article provides a general introduction to these novel therapeutic and diagnostic methods, and discusses their indications, contraindications, and potential limitations. The article aims to enable surgical pathologists to interact more efficiently with basic scientists and clinical colleagues to help implement and improve the existing clinical methods and to advance the new technologies. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3874602 Mon, 31 May 2010 23:00:00 +0100 3874602 http://www.medworm.com/index.php?rid=3874601&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110000243%2Fabstract%3Frss%3Dyes Abstract: Most epithelial neoplasms of the vermiform appendix are of mucinous type and can be stratified into 3 main diagnostic categories: (1) adenoma, (2) mucinous neoplasms of uncertain malignant potential or low-grade mucinous neoplasm, and (3) adenocarcinoma. Clinically, appendiceal mucinous adenomas and adenocarcinomas may present as right lower abdominal pain mimicking acute appendicitis, a mass, or pseudomyxoma peritonei. Nomenclature currently in use to describe and diagnose mucinous tumors of the appendix, particularly those of low morphologic grade, varies among surgical pathologists and centers, resulting in different histologic and clinical features being attributed to these entities in the literature. It may be of help, as already attempted by some investigators, to simply ap... Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3874601 Mon, 31 May 2010 23:00:00 +0100 3874601 http://www.medworm.com/index.php?rid=3874600&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110000218%2Fabstract%3Frss%3Dyes This article discusses the differential diagnosis of the various patterns of injury, including ischemic damage, and the histologic findings specific for certain drugs. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3874600 Mon, 31 May 2010 23:00:00 +0100 3874600 http://www.medworm.com/index.php?rid=3874599&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110000188%2Fabstract%3Frss%3Dyes Abstract: Involvement of the upper gastrointestinal tract by inflammatory bowel disease was long held to be a feature of Crohn's disease, whereas ulcerative colitis was considered to be limited to the colon. It is now recognized that ulcerative colitis associated inflammation can involve the upper gastrointestinal tract, primarily the stomach. In addition to aphthoid esophageal ulcers in Crohn's disease, eosinophilic esophagitis and so-called lymphocytic esophagitis occur in association with ulcerative colitis and Crohn's disease. Possible immune mechanisms behind these conditions are presented. The differential diagnosis of inflammation in each site is discussed. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3874599 Mon, 31 May 2010 23:00:00 +0100 3874599 http://www.medworm.com/index.php?rid=3874598&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110000176%2Fabstract%3Frss%3Dyes This article describes general and site-specific features of these tumors and outlines potential pitfalls in diagnosis. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3874598 Mon, 31 May 2010 23:00:00 +0100 3874598 http://www.medworm.com/index.php?rid=3874597&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110000231%2Fabstract%3Frss%3Dyes Abstract: Gastrointestinal (GI) infections are a major cause of morbidity and mortality worldwide. Although infectious organisms are often recovered by microbiological methods, surgical pathologists play an invaluable role in diagnosis. The lower GI tract, including the appendix, large bowel, and anus, harbors a wide variety of pathogens. Some infections are part of disseminated disease, whereas others produce clinicopathologic scenarios that are specific to the lower GI tract. This review focuses on selected infectious disorders of the lower GI tract that may be encountered by the general surgical pathologist, including viral, bacterial, fungal, and parasitic organisms, and including infections caused by food- and water-borne pathogens. Diagnostic gross and histologic features are discuss... Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3874597 Mon, 31 May 2010 23:00:00 +0100 3874597 http://www.medworm.com/index.php?rid=3874596&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110000206%2Fabstract%3Frss%3Dyes Abstract: The presence of esophageal eosinophilia encompasses a broad differential diagnosis, and at times a specific histologic diagnosis is not possible. This content provides a systematic approach to esophageal squamous eosinophilia with emphasis on specific, distinguishing features within this expansive differential. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3874596 Mon, 31 May 2010 23:00:00 +0100 3874596 http://www.medworm.com/index.php?rid=3874595&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS187591811000022X%2Fabstract%3Frss%3Dyes This article summarizes the gross, microscopic, and molecular findings of GISTs, and discusses the differential diagnosis and key attributes of this interesting group of neoplasms. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3874595 Mon, 31 May 2010 23:00:00 +0100 3874595 http://www.medworm.com/index.php?rid=3874594&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110000152%2Fabstract%3Frss%3Dyes This article discusses hyperplastic polyps, sessile serrated adenoma, traditional serrated adenoma, mixed polyps, and serrated lesions in such conditions as idiopathic inflammatory bowel disease and mechanical trauma. The major focus of the content is on diagnostic features of these lesions. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3874594 Mon, 31 May 2010 23:00:00 +0100 3874594 http://www.medworm.com/index.php?rid=3874593&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110000620%2Fabstract%3Frss%3Dyes As a practicing gastrointestinal pathologist, I am faced with difficult-to-interpret biopsies and complex resection specimens every day. In speaking to many other gastrointestinal pathologists from around the country and around the world, I have come to the conclusion that the same difficult problems that plague me on a daily basis also plague my colleagues, which I suppose offers some measure of comfort. Nevertheless, when given the opportunity to serve as consulting editor for the Surgical Pathology Clinics series, I relished the chance to find guest editors and authors who could address at least some of these challenging topics. I was incredibly fortunate when Dr. John Hart from the University of Chicago and his former colleague, Dr. Amy Noffsinger, now at the University of Cincinnati,... Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3874593 Mon, 31 May 2010 23:00:00 +0100 3874593 http://www.medworm.com/index.php?rid=3874592&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS187591811000070X%2Fabstract%3Frss%3Dyes (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3874592 Mon, 31 May 2010 23:00:00 +0100 3874592 http://www.medworm.com/index.php?rid=3874591&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110000693%2Fabstract%3Frss%3Dyes (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3874591 Mon, 31 May 2010 23:00:00 +0100 3874591 http://www.medworm.com/index.php?rid=3874590&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110000681%2Fabstract%3Frss%3Dyes (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3874590 Mon, 31 May 2010 23:00:00 +0100 3874590 http://www.medworm.com/index.php?rid=3735535&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110000401%2Fabstract%3Frss%3Dyes (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3735535 Mon, 01 Mar 2010 00:00:00 +0100 3735535 http://www.medworm.com/index.php?rid=3735534&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109001202%2Fabstract%3Frss%3Dyes In the article, Sentinel Lymph Nodes in Cutaneous Melanoma by Victor Prieto in the September 2009 Dermatopathology issue, Figure 4A on page 558 was printed incorrectly and shows, instead of a nodal nevus, a metastatic melanoma to intraparenchymal location. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3735534 Mon, 01 Mar 2010 00:00:00 +0100 3735534 http://www.medworm.com/index.php?rid=3735533&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110000061%2Fabstract%3Frss%3Dyes This article reviews the essential radiologic and pathologic findings in hypersensitivity pneumonitis, discusses the primary considerations in the differential diagnosis, and offers an approach to biopsy evaluation. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3735533 Mon, 01 Mar 2010 00:00:00 +0100 3735533 http://www.medworm.com/index.php?rid=3735532&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110000139%2Fabstract%3Frss%3Dyes This article focuses on the histologic changes diagnostic of a variety of primary and secondary small airways diseases. Because the histologic features involve bronchioles, gross findings are often minimal and/or nonspecific. The article provides a nonexhaustive examination of conditions and diseases involving the small airways, focusing on the microscopic features, with emphasis on the limitations of histologic diagnosis and differential diagnosis. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3735532 Mon, 01 Mar 2010 00:00:00 +0100 3735532 http://www.medworm.com/index.php?rid=3735531&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS187591811000005X%2Fabstract%3Frss%3Dyes This article reviews the more common vasculitic syndromes involving the lung, concentrating primarily on Wegener granulomatosis, Churg-Strauss syndrome, necrotizing sarcoid, microscopic polyangiitis, and diffuse alveolar hemorrhage syndromes. The article focuses on a review of the recent literature, diagnostic approach, and differential diagnosis. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3735531 Mon, 01 Mar 2010 00:00:00 +0100 3735531 http://www.medworm.com/index.php?rid=3735530&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110000103%2Fabstract%3Frss%3Dyes This article describes a practical approach for the evaluation of lymphoid and plasma cell infiltrates in the lung through the identification of several key histologic features. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3735530 Mon, 01 Mar 2010 00:00:00 +0100 3735530 http://www.medworm.com/index.php?rid=3735529&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110000140%2Fabstract%3Frss%3Dyes This article examines the assessment asbestos-related malignant mesothelioma and lung cancer. The risk of developing these diseases increases in proportion to the cumulative dose. As persons with heavy occupational asbestos exposures are diminishing, the observed latent period for asbestos-related disease extends making the assessment of an individual's cumulative dose is now more problematic. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3735529 Mon, 01 Mar 2010 00:00:00 +0100 3735529 http://www.medworm.com/index.php?rid=3735528&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110000115%2Fabstract%3Frss%3Dyes Abstract: Malignant mesothelioma (MM) is a rare primary malignant tumor of the surface serosal cells. The diagnosis of MM is challenging with a broad differential diagnosis. For many decades, studies have focused on distinguishing MM from other types of cancer; however, benign mesothelial cell hyperplasia, especially in small biopsies, has emerged as a major problem. The features of pleural lesions are somewhat different from peritoneal diseases, and this article primarily focuses on pleural diseases. Thorough interpretation and correlation of clinical, radiologic, and pathologic findings are essential for a correct diagnosis. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3735528 Mon, 01 Mar 2010 00:00:00 +0100 3735528 http://www.medworm.com/index.php?rid=3735527&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110000127%2Fabstract%3Frss%3Dyes Abstract: This review focuses on targeted therapies in lung cancer, the molecular biomarkers that help identify patients who will benefit from these targeted therapies, and describes the basic molecular biology principles and selected molecular diagnostic techniques and the pathologic features correlated with molecular abnormalities in lung cancer. New molecular abnormalities described in lung cancer that are predictive to novel promising targeted agents in various phases of clinical trials are discussed. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3735527 Mon, 01 Mar 2010 00:00:00 +0100 3735527 http://www.medworm.com/index.php?rid=3735526&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110000097%2Fabstract%3Frss%3Dyes Abstract: The tumor-node-metastasis (TNM) system is the most commonly used staging system for cancers, including lung cancer. The TNM descriptors and the stage groupings reflect differences in patient prognosis and choices for specific therapies. Generally, the higher the T, N, or M, and the higher the stage grouping, the worse the prognosis is for patients in that category. TNM stage is traditionally the most important factor predicting survival of lung cancer patients. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3735526 Mon, 01 Mar 2010 00:00:00 +0100 3735526 http://www.medworm.com/index.php?rid=3735525&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110000085%2Fabstract%3Frss%3Dyes Abstract: Pulmonary neuroendocrine tumors are frequently encountered as small biopsy and resection specimens. Although the World Health Organization (WHO) classification is used as a diagnostic framework globally and in daily practice, it is not without controversy and practical difficulties. The WHO criteria for pulmonary neuroendocrine tumors are reviewed with the recognition that the definitions are based on resected specimens, which are often not the usual clinical circumstances. A practical approach is emphasized, and the differential diagnosis is discussed with particular attention to the context in which diagnostic difficulties are most frequently encountered, such as small biopsies and frozen sections. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3735525 Mon, 01 Mar 2010 00:00:00 +0100 3735525 http://www.medworm.com/index.php?rid=3735524&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110000073%2Fabstract%3Frss%3Dyes Abstract: The most recent WHO classification of lung cancer defines bronchioloalveolar carcinoma (BAC) as a noninvasive carcinoma or adenocarcinoma in situ. However, the use of this terminology is not uniform and does not reflect standardized criteria. As a result, the diagnosis of BAC has been used in association with small, solitary, and well-differentiated adenocarcinoma as well as tumors with advanced clinical stage. At present, there is a growing consensus among specialists in thoracic oncology that BAC or adenocarcinoma in situ is a rare tumor, and the term should be restricted to adenocarcinomas that show a pure lepidic pattern of growth. The amount of invasive component present in a tumor with a predominant lepidic growth pattern has also been under intense scrutiny. The concept of... Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3735524 Mon, 01 Mar 2010 00:00:00 +0100 3735524 http://www.medworm.com/index.php?rid=3735523&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110000255%2Fabstract%3Frss%3Dyes Diseases of the lung and pleura may be challenging for practicing general surgical pathologists. This has became more obvious in recent years as we all witness the transformation of medicine into many highly specialized areas targeting different organ systems and even a single disease. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3735523 Mon, 01 Mar 2010 00:00:00 +0100 3735523 http://www.medworm.com/index.php?rid=3735522&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110000395%2Fabstract%3Frss%3Dyes (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3735522 Mon, 01 Mar 2010 00:00:00 +0100 3735522 http://www.medworm.com/index.php?rid=3735521&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110000383%2Fabstract%3Frss%3Dyes (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3735521 Mon, 01 Mar 2010 00:00:00 +0100 3735521 http://www.medworm.com/index.php?rid=3735520&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918110000371%2Fabstract%3Frss%3Dyes (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3735520 Mon, 01 Mar 2010 00:00:00 +0100 3735520 http://www.medworm.com/index.php?rid=3038006&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109001007%2Fabstract%3Frss%3Dyes (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3038006 Mon, 30 Nov 2009 15:12:19 +0100 3038006 http://www.medworm.com/index.php?rid=3038005&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109000658%2Fabstract%3Frss%3Dyes Abstract: Mesenchymal tumors of the female genital tract include various benign and malignant neoplasms. Mesenchymal tumors may arise from the stroma or associated elements of the organ of origin, such as connective tissue, vascular or neural structures, or others. Malignant mesenchymal tumors of the female genital tract represent a rare group of gynecologic cancers. They are generally aggressive tumors, with a propensity for local and distant recurrence. The mainstay of treatment usually involves surgical excision of the primary tumor. Malignant mesenchymal tumors of the female genital tract are generally refractory to systemic chemotherapy and radiation therapy. This review highlights the treatment options for the most common types of mesenchymal tumors of the female genital tract. (Sour... Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3038005 Mon, 30 Nov 2009 15:12:19 +0100 3038005 http://www.medworm.com/index.php?rid=3038004&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109000646%2Fabstract%3Frss%3Dyes This article focuses on current understanding of the molecular genetics of mesenchymal tumors of the female genital tract, with emphasis on diagnostic and prognostic molecular features. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3038004 Mon, 30 Nov 2009 15:12:19 +0100 3038004 http://www.medworm.com/index.php?rid=3038003&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109000634%2Fabstract%3Frss%3Dyes This article reviews the information currently available on genetic changes in mesenchymal tumors of the female genital tract and, more specifically, those reported in the uterus, where they have been more frequently studied. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3038003 Mon, 30 Nov 2009 15:12:19 +0100 3038003 http://www.medworm.com/index.php?rid=3038002&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109000610%2Fabstract%3Frss%3Dyes Abstract: Pure mesenchymal tumors may occur anywhere in the female genital tract, but they are most common in the uterine corpus, leiomyoma being by far the most prevalent. These tumors, and other uncommon mesenchymal lesions within the uterine corpus and elsewhere in the female genital tract, may result in several diagnostic problems. Morphology remains paramount and, in most cases, an unequivocal diagnosis can be made based on examination of the hematoxylin and eosin stained sections, combined with an appreciation of the clinical and gross pathologic features. In difficult cases, immunohistochemistry can significantly contribute to the final diagnosis. In this article, the immunohistochemistry of neoplastic and nonneoplastic mesenchymal lesions of the female genital tract is discussed si... Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3038002 Mon, 30 Nov 2009 15:12:19 +0100 3038002 http://www.medworm.com/index.php?rid=3038001&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109000609%2Fabstract%3Frss%3Dyes This article outlines several mesenchymal lesions reported in the female genital tract, encompassing recent histologic, immunohistochemical, and molecular findings, with special emphasis on problems in the differential diagnosis. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3038001 Mon, 30 Nov 2009 15:12:18 +0100 3038001 http://www.medworm.com/index.php?rid=3038000&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109000580%2Fabstract%3Frss%3Dyes This article reviews fibromatous ovarian tumors, emphasizing cellular fibromas and their differential diagnosis. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3038000 Mon, 30 Nov 2009 15:12:18 +0100 3038000 http://www.medworm.com/index.php?rid=3037999&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109000592%2Fabstract%3Frss%3Dyes Abstract: Malignant mixed müllerian tumor (MMMT) and müllerian/mesodermal adenosarcoma are 2 of the most common mixed müllerian tumors of the female genital tract. MMMT is a biphasic neoplasm, composed of morphologically malignant epithelial and stromal components. MMMT should be distinguished from endometrioid adenocarcinoma with spindle cell elements, “dedifferentiated” endometrioid carcinoma, and combined adenocarcinoma and neuroendocrine carcinoma. Adenosarcoma is also biphasic; it is composed of morphologically benign or low-grade appearing epithelial components and malignant stromal components. The differential diagnosis of adenosarcoma includes MMMT, endometrial stromal tumor containing endometrioid glands, benign endometrial or endocervical polyp, adenofibroma, adenomyoma, ... Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3037999 Mon, 30 Nov 2009 15:12:18 +0100 3037999 http://www.medworm.com/index.php?rid=3037998&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS187591810900066X%2Fabstract%3Frss%3Dyes Abstract: Endometrial/ioid stromal tumors comprise a spectrum of mesenchymal neoplasms, ranging from benign to low-grade malignancy to undifferentiated sarcomas, which occur predominantly in the uterus but may rarely originate at extrauterine sites, most commonly in the ovary. These tumors and their morphologic variants are important to recognize as they often cause diagnostic difficulties. This review focuses on the diagnostic criteria and differential diagnosis, including the role of immunohistochemistry. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3037998 Mon, 30 Nov 2009 15:12:18 +0100 3037998 http://www.medworm.com/index.php?rid=3037997&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109000622%2Fabstract%3Frss%3Dyes This article discusses conventional smooth muscle tumors as well as unusual subtypes, with emphasis on the diagnostic criteria and problems in differential diagnosis that arise at each site within the female genital tract. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3037997 Mon, 30 Nov 2009 15:12:18 +0100 3037997 http://www.medworm.com/index.php?rid=3037996&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109000579%2Fabstract%3Frss%3Dyes Abstract: A variety of site-specific mesenchymal lesions of the lower genital tract may occur, which are often diagnostically challenging because of their morphologic overlap. Some of this morphologic homogeneity presumably stems from a potentially shared origin from the specialized superficial stroma of the distal female genital tract. Despite shared appearances, morphologic distinction remains the gold standard for diagnosis of most of these lesions, as immunoperoxidase staining is often not helpful in their distinction. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3037996 Mon, 30 Nov 2009 15:12:18 +0100 3037996 http://www.medworm.com/index.php?rid=3037995&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109000567%2Fabstract%3Frss%3Dyes This article highlights the imaging features of the most commonly encountered mesenchymal tumors in the female genital tract. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3037995 Mon, 30 Nov 2009 15:12:18 +0100 3037995 http://www.medworm.com/index.php?rid=3037994&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109000804%2Fabstract%3Frss%3Dyes Among the spectrum of neoplasms that involve the female genital tract, mesenchymal tumors, albeit uncommon, represent one of the most challenging areas in our practice. The main goal of this issue of The Surgical Pathology Clinics series on mesenchymal tumors of the female genital tract is to approach these relatively unusual tumors in a systematic, practical, and integrated fashion, while providing at the same time a comprehensive and updated review. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3037994 Mon, 30 Nov 2009 15:12:18 +0100 3037994 http://www.medworm.com/index.php?rid=3037993&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109000993%2Fabstract%3Frss%3Dyes (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3037993 Mon, 30 Nov 2009 15:12:18 +0100 3037993 http://www.medworm.com/index.php?rid=3037992&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109000981%2Fabstract%3Frss%3Dyes (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=3037992 Mon, 30 Nov 2009 15:12:18 +0100 3037992 http://www.medworm.com/index.php?rid=2945776&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109000749%2Fabstract%3Frss%3Dyes (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=2945776 Tue, 01 Sep 2009 00:00:00 +0100 2945776 http://www.medworm.com/index.php?rid=2945775&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109000531%2Fabstract%3Frss%3Dyes This article describes the handful of “signature” changes that are known to occur, describes how some recent studies have shed light on changes beyond this signature, and finally discusses the impact of molecular pathology for practicing histopathologists. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=2945775 Tue, 01 Sep 2009 00:00:00 +0100 2945775 http://www.medworm.com/index.php?rid=2945774&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109000488%2Fabstract%3Frss%3Dyes Abstract: Examination of sentinel lymph nodes (SLN) has probably become the most popular method of early staging of patients who have cutaneous melanoma because SLN are considered to be the lymph nodes most likely to contain metastatic deposits; they can be examined in a more intense manner than in standard lymphadenectomy. There are several protocols to examine SLN but most of them use formalin-fixed, paraffin-embedded sections stained with hematoxylin and eosin with the addition of immunohistochemistry. By using these protocols, approximately 20% of patients who have cutaneous melanoma have melanoma cells in the SLN. Current studies are evaluating the possible therapeutic value of removal of positive SLN, but it is accepted by most authors that detection of positive SLN conveys an impair... Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=2945774 Tue, 01 Sep 2009 00:00:00 +0100 2945774 http://www.medworm.com/index.php?rid=2945773&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109000476%2Fabstract%3Frss%3Dyes Abstract: Primary cutaneous melanoma is treated by excisional surgery and careful histologic assessment of the specimen margins is a crucial component of pathology reporting. Surgical margins may be assessed by conventional transverse (bread-loaf) vertical sections, by en face vertical sections, or by en face oblique sections. Transverse techniques only sample a small percentage of the surgical margin. En face techniques are technically challenging but allow assessment of close to 100% of the margin. Margin assessment for melanoma removed from chronically sun-damage skin is difficult. Melanoma in situ shows contiguous melanocyte growth, nesting, or intraepidermal pagetoid spread. Pitfalls include solar melanocytic hyperplasia, solar lentigines, melanocytic hyperplasia secondary to previous... Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=2945773 Tue, 01 Sep 2009 00:00:00 +0100 2945773 http://www.medworm.com/index.php?rid=2945772&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109000464%2Fabstract%3Frss%3Dyes Abstract: Acral lentiginous melanoma is an uncommon skin malignancy that occurs with equal frequency in all races and has a worse prognosis than other types of melanoma; it presents as dark, irregular macules, papules, or nodules on the feet and, less commonly, the hands. The histologic findings of acral lentiginous melanoma are characterized by an asymmetric, poorly circumscribed proliferation of continuous single melanocytes at the dermoepidermal junction. Single melanocytes predominate over nests. The tumor must be distinguished from benign acral lentiginous nevi, which can display site-related atypia. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=2945772 Tue, 01 Sep 2009 00:00:00 +0100 2945772 http://www.medworm.com/index.php?rid=2945771&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS187591810900052X%2Fabstract%3Frss%3Dyes This article discusses the key features of nevoid melanoma. Gross features, microscopic features, immunohistochemistry, differential diagnosis, diagnosis, prognosis, and treatment are also discussed. (Source: Surgical Pathology Clinics) Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=2945771 Tue, 01 Sep 2009 00:00:00 +0100 2945771 http://www.medworm.com/index.php?rid=2945770&cid=s_38673_32_f&fid=38673&url=http%3A%2F%2Fwww.surgpath.theclinics.com%2Farticle%2FPIIS1875918109000518%2Fabstract%3Frss%3Dyes Abstract: Desmoplastic melanoma (DM) is a variant of spindle cell melanoma characterized by the presence of abundant fibrous matrix. It is typically found in the head and neck region on chronically sun-damaged skin of older individuals. Early detection is uncommon, because its clinical features are not distinctive. DM is prone to misdiagnosis not only clinically but also histologically. It may simulate a sclerosing melanocytic nevus and various benign and malignant nonmelanocytic lesions. Among melanomas said to be desmoplastic by various pathologists there is significant variation with regard to the extent of intratumoral fibrosis. It may be prominent throughout the entire tumor (pure DM) or represent a portion of an otherwise nondesmoplastic melanoma (combined DM). Immunophenotypically, ... Surgical Pathology Clinics journals http://www.medworm.com/rss/comments.php?id=2945770 Tue, 01 Sep 2009 00:00:00 +0100 2945770