MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Swiss Medical Weekly' source. Wed, 08 Feb 2012 18:50:43 +0100 http://www.medworm.com/index.php?rid=5664841&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22287296%26dopt%3DAbstract CONCLUSION: The majority of 164 patients who presented with acutely and severely elevated blood pressure (BP >180 +/or >110 mm Hg) to their GPs was asymptomatic, had pre-existing hypertension and was managed in GP's office unless a hypertensive emergency was present. At three month follow-up mean systolic BP was still above target values. PMID: 22287296 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5664841 Tue, 07 Feb 2012 05:36:02 +0100 5664841 http://www.medworm.com/index.php?rid=5664840&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22287317%26dopt%3DAbstract This article provides an overview of current methods and trends in the field of non-invasive blood pressure measurement, an update on current clinical guidelines and an overview of blood pressure measurement in special populations. PMID: 22287317 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5664840 Tue, 07 Feb 2012 05:36:02 +0100 5664840 http://www.medworm.com/index.php?rid=5664839&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22290607%26dopt%3DAbstract CONCLUSIONS: Colonisation with P. aeruginosa was present in all COPD severity stages and colonisation with mucoid strains was more frequent in advanced COPD. Resistance to the only oral anti-pseudomonas antibiotic ciprofloxacin was more frequently encountered in severe COPD stages. PMID: 22290607 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5664839 Tue, 07 Feb 2012 05:36:02 +0100 5664839 http://www.medworm.com/index.php?rid=5664838&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22290632%26dopt%3DAbstract Authors: Mey U, Hitz F, Lohri A, Pederiva S, Taverna C, Tzankov A, Meier O, Yeow K, Renner C Abstract Diffuse large B-cell lymphoma (DLBCL) is the most frequently-occurring type of malignant lymphoma in the Western world. It has an aggressive natural history, with a median survival of less than one year if left untreated. Immunochemotherapy regimens, consisting of the anti-CD20 antibody rituximab typically in combination with cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP), are currently the treatment backbone. Despite remarkable progress in improving patient survival, clinical outcomes are still unsatisfactory for certain subsets of patients, including the elderly and very elderly and those with highly aggressive disease. This review outlines some of the current ... Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5664838 Tue, 07 Feb 2012 05:36:02 +0100 5664838 http://www.medworm.com/index.php?rid=5627724&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22270552%26dopt%3DAbstract Authors: Hofmann J, Wolf H, Grassmann A, Arndt V, Graham J, Vorberg I Abstract Transmissible spongiform encephalopathies are fatal neurodegenerative diseases that affect mammals including humans. The proteinaceous nature of the infectious agent, the prion, and its propagation, challenge established dogmas in biology. It is now widely accepted that prion diseases are caused by unconventional agents principally composed of a misfolded host-encoded protein, PrP. Surprisingly, major break-throughs in prion research came from studies on functionally unrelated proteins in yeast and filamentous fungi. Aggregates composed of these proteins act as epigenetic elements of inheritance that can propagate their alternative states by a conformational switch into an ordered ß-sheet rich polymer j... Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5627724 Thu, 26 Jan 2012 09:24:02 +0100 5627724 http://www.medworm.com/index.php?rid=5627723&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22270648%26dopt%3DAbstract CONCLUSIONS: The work-hour limitation implemented in Switzerland was not associated with surgical patient safety measure improvement for common surgeries (i.e., morbidity and mortality rate). Further research on a nationwide basis is needed to assess the value of the higher surgical complication and mortality rate. PMID: 22270648 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5627723 Thu, 26 Jan 2012 09:24:02 +0100 5627723 http://www.medworm.com/index.php?rid=5627722&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22271430%26dopt%3DAbstract CONCLUSIONS: The findings of this study suggest a need to improve the patient safety climate on many units in Swiss hospitals. Leaders in hospitals should strengthen the patient safety climate at unit level by implementing methods, such as root cause analysis or patient safety leadership walk rounds, to improve individual and team skills and redesign work processes. The impact of these efforts should be measured by periodically assessing the patient safety climate with the SOS. PMID: 22271430 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5627722 Thu, 26 Jan 2012 09:24:02 +0100 5627722 http://www.medworm.com/index.php?rid=5627721&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22271452%26dopt%3DAbstract Authors: von K Abstract Cardiovascular disease (CVD) is a major cause of morbidity and mortality worldwide. Epidemiologic research of the last half-century has clearly shown that psychosocial factors related to the social environment, personality characteristics, and negative affect increase the risk of incident CVD and also impact prognosis of cardiac patients. Several mechanisms may explain this link, including a genetic predisposition, poor lifestyle choices, low adherence to health recommendations, and direct pathophysiologic perturbations. The latter include alteration of the hypothalamic-pituitary adrenal axis and autonomic dysfunction resulting in endothelial dysfunction, inflammation, and a prothrombotic state further downstream. Screening for psychosocial factors seems app... Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5627721 Thu, 26 Jan 2012 09:24:02 +0100 5627721 http://www.medworm.com/index.php?rid=5627720&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22271487%26dopt%3DAbstract Authors: Fernández , Ameneiros-Lago E, Sesma P Abstract No abstract available. PMID: 22271487 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5627720 Thu, 26 Jan 2012 09:24:02 +0100 5627720 http://www.medworm.com/index.php?rid=5627719&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22271505%26dopt%3DAbstract Authors: Seitz M Abstract No abstract available. PMID: 22271505 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5627719 Thu, 26 Jan 2012 09:24:02 +0100 5627719 http://www.medworm.com/index.php?rid=5607726&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22252139%26dopt%3DAbstract CONCLUSION: When used in a large patient cohort, EST is a safe and simple diagnostic test. In this exploratory study EST is of value in evaluating patients with cytopenia and a positive EST argues strongly for hypersplenism. Future studies should prospectively evaluate EST for the management of patients with splenomegaly. PMID: 22252139 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5607726 Fri, 20 Jan 2012 11:24:09 +0100 5607726 http://www.medworm.com/index.php?rid=5607725&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22252171%26dopt%3DAbstract CONCLUSIONS: The epidemiologic data suggest that congenital syphilis could become a medical problem in Switzerland due to the rise of infectious syphilis cases in women of childbearing age that have been shown to be followed by changes in the congenital syphilis incidence. The persistence of congenital syphilis in Switzerland along with this rise of infectious syphilis in women of childbearing age suggests a potential for improvement of prenatal care and syphilis control programmes. PMID: 22252171 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5607725 Fri, 20 Jan 2012 11:24:09 +0100 5607725 http://www.medworm.com/index.php?rid=5607724&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22252245%26dopt%3DAbstract Authors: Cimmino MA, Barbieri F, Zampogna G, Camellino D, Paparo F, Parodi M Abstract Modern imaging techniques are becoming increasingly important in assessing the course of arthritis and in permitting measurement of response to treatment as part of the follow-up of patients. They include ultrasonography (US), MRI, PET/CT, and biofluorescence. In patients with rheumatoid arthritis, clinical evaluation is significantly less sensitive than either US or MRI in detecting synovitis. As a result, imaging is a useful alternative to achieving proper assessment of disease activity. The different areas in which the new imaging techniques could help practicing rheumatologists and internal physicians include the following: early and differential diagnosis of arthritis, evaluation of disease a... Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5607724 Fri, 20 Jan 2012 11:24:09 +0100 5607724 http://www.medworm.com/index.php?rid=5607723&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22252274%26dopt%3DAbstract CONCLUSIONS: Both ISAR and TRST tools predicted modestly unplanned readmission after an ED-visit among patients over 75 years. Nevertheless, due to their low specificity and high NPV these screening tools are useful to select elderly ED-patients who can safely return home without any further CGA. PMID: 22252274 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5607723 Fri, 20 Jan 2012 11:24:09 +0100 5607723 http://www.medworm.com/index.php?rid=5607722&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22252905%26dopt%3DAbstract Authors: Guxens M, Sunyer J Abstract The aim of the present review is to provide an update of the epidemiological evidence of the effects of air pollution on neuropsychological development and impairment, as well as of the evidence on individual susceptibility to these effects. Animal studies have shown deposition of ultrafine particles containing metals in olfactory bulb and frontal cortical and subcortical areas, and overexpression of inflammatory responses, white matter lesions and vascular pathology in these areas that could be the basis for functional and structural brain effects. Several observational studies in the general population have observed cognitive deficits and behavioural impairment in children and the elderly. These effects, however, are not conclusive given the l... Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5607722 Fri, 20 Jan 2012 11:24:09 +0100 5607722 http://www.medworm.com/index.php?rid=5607721&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22252925%26dopt%3DAbstract CONCLUSION: In the HIV population, increased homocysteine serum level is associated with sexual risk behaviour and hepatitis C virus coinfection. PMID: 22252925 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5607721 Fri, 20 Jan 2012 11:24:09 +0100 5607721 http://www.medworm.com/index.php?rid=5541338&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22180157%26dopt%3DAbstract CONCLUSIONS: From an epidemiologic point of view, patient history is the best way to predict the origin of PJI. Blind additional radiographic or endoscopic exams are costly, inconclusive and do not contribute to the management of these cases. PMID: 22180157 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5541338 Mon, 26 Dec 2011 00:12:03 +0100 5541338 http://www.medworm.com/index.php?rid=5541337&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22180171%26dopt%3DAbstract In conclusion, in the near future, smart devices will integrate with the human body to fill functional gaps due to organ failure, and so create a human chimera. PMID: 22180171 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5541337 Mon, 26 Dec 2011 00:12:03 +0100 5541337 http://www.medworm.com/index.php?rid=5541336&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22180191%26dopt%3DAbstract CONCLUSIONS: Giving way, locking and McMurray's test are independent clinical diagnostic factors for the diagnosis of meniscal tears. MRI has higher accuracy, sensitivity and NPV for the diagnosis of meniscal tears than giving way, locking and McMurray's test. The combination of giving way, locking, McMurray's test and MRI for confirmation is typical for a meniscal lesion diagnosis. Based on these findings, MRI should be used in a standard manner to detect meniscal tears found during arthroscopy. PMID: 22180191 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5541336 Mon, 26 Dec 2011 00:12:03 +0100 5541336 http://www.medworm.com/index.php?rid=5541335&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22180219%26dopt%3DAbstract Authors: Berger P, Ballmer-Hofer K Abstract Vascular endothelial growth factors (VEGFs) regulate blood and lymph vessel formation through activation of the type V receptor tyrosine kinases VEGFR-1, -2 and -3. In addition, VEGFs interact with co-receptors such as neuropilins, integrins, semaphorins or heparansulfate glycosaminoglycans. Ligand binding dimerises the receptors and activates their intracellular tyrosine kinase domains, resulting in phosphorylation of tyrosine residues acting as docking sites for intracellular signalling molecules. Ligand-induced receptor is internalised and then transported through early, late, and recycling endosomes, and finally degraded by proteasomal or lysosomal pathways. Biological output by VEGF is mediated through distinct receptor/co-receptor c... Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5541335 Mon, 26 Dec 2011 00:12:03 +0100 5541335 http://www.medworm.com/index.php?rid=5541334&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22180245%26dopt%3DAbstract Authors: Dummer R, Guggenheim M, Arnold AW, Braun R, von Moos R Abstract Melanoma is the most common lethal cutaneous neoplasm. In order to harmonise treatment and follow-up of melanoma patients, guidelines for the management of melanoma in Switzerland were inaugurated in 2001 and revised in 2006. A new classification and recent results in randomised trials necessitated changes concerning staging and modifications of the recommendations of therapy and follow-up. PMID: 22180245 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5541334 Mon, 26 Dec 2011 00:12:03 +0100 5541334 http://www.medworm.com/index.php?rid=5541333&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22183715%26dopt%3DAbstract Authors: Schaub MC Abstract Mechanical devices are sought to support insufficient or paralysed striated muscles including the failing heart. Nickel-titanium alloys (nitinol) present the following two properties: (i) super-elasticity, and (ii) the potential to assume different crystal structures depending on temperature and/or stress. Starting from the martensite state nitinol is able to resume the austenite form (state of low potential energy and high entropy) even against an external resistance. This one-way shape change is deployed in self-expanding vascular stents. Heating induces the force generating transformation from martensite to the austenite state while cooling induces relaxation back to the martensite state. This two-way shape change oscillating between the two states ma... Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5541333 Mon, 26 Dec 2011 00:12:03 +0100 5541333 http://www.medworm.com/index.php?rid=5519534&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21623474%26dopt%3DAbstract Authors: Künzli N PMID: 21623474 [PubMed - indexed for MEDLINE] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5519534 Tue, 20 Dec 2011 02:12:03 +0100 5519534 http://www.medworm.com/index.php?rid=5519533&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21720970%26dopt%3DAbstract CONCLUSIONS: Chest compression training showed weakness for four out of five variables. Only the end results for compression depth were satisfactory. The deficits observed in the training on chest compression were relevant and must be remedied. One possibility would be initial step-by-step training and assessment of each component of chest compression, concentrating in particular on hand positioning and compression/decompression ratio. PMID: 21720970 [PubMed - indexed for MEDLINE] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5519533 Tue, 20 Dec 2011 02:12:03 +0100 5519533 http://www.medworm.com/index.php?rid=5519532&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22161787%26dopt%3DAbstract CONCLUSION: Less than one fifth of our stroke patients presented to hospital within 2 hours. Although our results are preliminary given their limited generalisability and the retrospective nature of data collection, medical rather than social factors were found to be associated with time of presenting to hospital. Patients with severe symptoms presented to the hospital at an earlier stage after stroke onset. It is important to promote the earliest possible presentation to hospital after a stroke. PMID: 22161787 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5519532 Tue, 20 Dec 2011 02:12:03 +0100 5519532 http://www.medworm.com/index.php?rid=5519531&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22161820%26dopt%3DAbstract CONCLUSIONS: These results showed that altruism and gratuity were key-values in the organ donation and transplantation social perceptions of the respondents. Thus, we assume that introducing financial incentives could tarnish the image of transplant medicine. Nevertheless, further studies are needed to evaluate if their introduction would improve the organ donation rates or decrease voluntarism. PMID: 22161820 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5519531 Tue, 20 Dec 2011 02:12:03 +0100 5519531 http://www.medworm.com/index.php?rid=5519530&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22161870%26dopt%3DAbstract Authors: Cuculi F, De Caterina AR, Kharbanda RK, Banning AP Abstract Coronary microcirculation plays a crucial role for the outcomes of patients with STEMI. Although PPCI improves outcomes compared to thrombolysis, a substantial amount of STEMI patients do not achieve optimal myocardial reperfusion. Angiographic methods for assessment of reperfusion like TIMI Flow and MBG are easy to use but new, catheter laboratory based techniques to assess reperfusion have a lot of potential to assess and potentially guide management of patients with STEMI. PMID: 22161870 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5519530 Tue, 20 Dec 2011 02:12:03 +0100 5519530 http://www.medworm.com/index.php?rid=5483057&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22143894%26dopt%3DAbstract CONCLUSION: Higher-order multiple births have a high morbidity that has not improved over the last two decades. The incidence of higher-order multiple births is still increasing, which demonstrates that reproductive medicine in Switzerland is not yet sufficiently controlled and monitored. PMID: 22143894 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5483057 Thu, 08 Dec 2011 10:18:04 +0100 5483057 http://www.medworm.com/index.php?rid=5483056&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22143914%26dopt%3DAbstract CONCLUSIONS: The inflammatory response, manifested by serum levels of inflammatory factors and nuclear accumulation of activated NF-κB P65, was more serious in the IH group than in the SH and control group, and was dependent on hypoxia levels. This reaction increased initially and then decreased, which indicates the presence of compensatory mechanisms and an adaptive response to such stressors in the body. Notably, the correlation of NFκB activation to production of inflammatory factors under intermittent hypoxia implies an important role of this transcription factor in inflammation-induced cardiovascular damage occurring during obstructive sleep apnoea (OSA), which has a typical breathing pattern of intermittent hypoxia. PMID: 22143914 [PubMed - in process] (Source: Swiss Medical We... Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5483056 Thu, 08 Dec 2011 10:18:04 +0100 5483056 http://www.medworm.com/index.php?rid=5483055&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22144395%26dopt%3DAbstract CONCLUSION: A(H1N1)pdm09 has become a ubiquitous seasonal virus in the region. Complications were uncommon and non life threatening. In the event of new influenza outbreaks, hygienic and containment measures must be quickly and correctly implemented, in order to avoid an epidemic. This should also be considered in non-military settings like school camps or in retirement homes. PMID: 22144395 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5483055 Thu, 08 Dec 2011 10:18:04 +0100 5483055 http://www.medworm.com/index.php?rid=5448174&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22101745%26dopt%3DAbstract CONCLUSION: This study showed comparable effects of PPX versus dual-release L/B for short-term treatment of de novo patients with mild to moderate RLS. PMID: 22101745 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5448174 Sat, 26 Nov 2011 19:06:05 +0100 5448174 http://www.medworm.com/index.php?rid=5448173&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22101804%26dopt%3DAbstract CONCLUSIONS: The incidence of catheter related blood stream infection in critically ill patients on intensive care units treated with continuous veno-venous haemo(dia)filtration was 3.8 per 1000 catheter days. All catheter related blood stream infections were caused by coagulase negative staphylococci. PMID: 22101804 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5448173 Sat, 26 Nov 2011 19:06:05 +0100 5448173 http://www.medworm.com/index.php?rid=5448172&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22101855%26dopt%3DAbstract Authors: Fernández-Fernández FJ, Sesma P, Ameneiros-Lago E Abstract No abstract available. PMID: 22101855 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5448172 Sat, 26 Nov 2011 19:06:05 +0100 5448172 http://www.medworm.com/index.php?rid=5448171&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22101891%26dopt%3DAbstract This article summarises the results of current studies on fall prevention, with a particular focus on methodological quality and successful reduction of fall incidence in vulnerable older people. Characteristics of effective fall prevention programmes in the fields of exercise, home modifications, appropriate footwear and walking aids are assessed. We then briefly discuss how these study results can be adapted to the Swiss context. This knowledge emphasises an interdisciplinary approach in the prevention of falls, the objective being to reinforce autonomy, promote health and enhance quality of life in vulnerable older people. PMID: 22101891 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5448171 Sat, 26 Nov 2011 19:06:05 +0100 5448171 http://www.medworm.com/index.php?rid=5448170&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22101921%26dopt%3DAbstract Authors: Rutishauser J Abstract Statins inhibit cholesterol biosynthesis. Their main effect is a decrease in circulating levels of LDL cholesterol, which translates into a ~ 20% relative reduction of major vascular events and coronary mortality per mmol/L LDL reduction achieved. Statins are efficient in preventing first cardiovascular events, but the cost-efficiency of primary prevention remains controversial. In primary prevention particularly, the pros and cons of statin therapy should be weighted by considering patient-specific life circumstances and assessing the individual cardiovascular risk, as provided by risk calculators. Since diabetes mellitus poses a high risk even in the absence of known coronary artery disease, statin treatment is generally indicated in these patients... Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5448170 Sat, 26 Nov 2011 19:06:05 +0100 5448170 http://www.medworm.com/index.php?rid=5448169&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22105207%26dopt%3DAbstract Reply to the letter to the editor "Comment on 'Pre- and intra-operative mediastinal staging in non-small-cell lung cancer'" Swiss Med Wkly. 2011;141:w13288 Authors: Lardinois D Abstract No abstract available. PMID: 22105207 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5448169 Sat, 26 Nov 2011 19:06:05 +0100 5448169 http://www.medworm.com/index.php?rid=5448168&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22105245%26dopt%3DAbstract Comment on "Pre- and intra-operative mediastinal staging in non-small-cell lung cancer" Swiss Med Wkly. 2011;141:w13289 Authors: von Garnier C, Geiser T Abstract No abstract available. PMID: 22105245 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5448168 Sat, 26 Nov 2011 19:06:05 +0100 5448168 http://www.medworm.com/index.php?rid=5448167&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22105328%26dopt%3DAbstract Authors: Fernández-Fernández FJ Abstract No abstract available. PMID: 22105328 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5448167 Sat, 26 Nov 2011 19:06:05 +0100 5448167 http://www.medworm.com/index.php?rid=5448166&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22105375%26dopt%3DAbstract Reply to the letter to the editor " Calcium supplementation, vitamin K status and cardiovascular disease: an additional point" Swiss Med Wkly. 2011;141:w13301 Authors: Suter PM, Erne P Abstract No abstract available. PMID: 22105375 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5448166 Sat, 26 Nov 2011 19:06:05 +0100 5448166 http://www.medworm.com/index.php?rid=5429239&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22065243%26dopt%3DAbstract CONCLUSIONS: DLG5 P1371Q was associated with IBD and this association was female-specific. A significant epistatic interaction between P1371Q and R30Q was observed, suggesting that P1371Q is complementary to R30Q, with R30Q exhibiting a dominant effect in IBD susceptibility. PMID: 22065243 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5429239 Sun, 20 Nov 2011 23:12:02 +0100 5429239 http://www.medworm.com/index.php?rid=5429238&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22065249%26dopt%3DAbstract Authors: Krueger T, Berutto C, Aubert JD Abstract Lung transplantation is an established therapy for end-stage pulmonary disorders in selected patients without significant comorbidities. The particular constraints associated with organ transplantation from deceased donors involve specific allocation rules in order to optimise the medical efficacy of the procedure. Comparison of different policies adopted by national transplant agencies reveals that an optimal and unique allocation system is an elusive goal, and that practical, geographical and logistic parameters must be taken into account. A solution to attenuate the imbalance between the number of lung transplant candidates and the limited availability of organs is to consider marginal donors. In particular, assessment and restor... Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5429238 Sun, 20 Nov 2011 23:12:02 +0100 5429238 http://www.medworm.com/index.php?rid=5429237&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22065258%26dopt%3DAbstract CONCLUSIONS: Due to the significant interest of participants, the establishment of a national research network should be considered. An established clinic for coordinating research alongside an additional web-based platform to target young surgeons could function as an umbrella organisation. PMID: 22065258 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5429237 Sun, 20 Nov 2011 23:12:02 +0100 5429237 http://www.medworm.com/index.php?rid=5429236&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22065276%26dopt%3DAbstract CONCLUSION: Intraoperative PTH assay may allow intraoperative monitoring of parathyroid function, predicting postoperative outcomes, may identify patients at risk of developing postoperative hypoparathyroidism, guiding surgeons to re-examine removed specimens for inadvertently removed parathyroid tissue with possible auto transplantation, or more practically a guide to early replacement therapy to prevent hypocalcaemia, leading to safe and early hospital discharge. Limitations in our study to be reconsidered in further studies, are relative small sample size, inability for randomisation, and the variable values reported for the cut off value of PTH causing hypocalcaemic symptoms needing intervention. PMID: 22065276 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5429236 Sun, 20 Nov 2011 23:12:02 +0100 5429236 http://www.medworm.com/index.php?rid=5429235&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22065282%26dopt%3DAbstract CONCLUSIONS: High symptom prevalence at start of chemotherapy as well as over time and great variability in symptom experience call for an individual, systematic symptom assessment and management that does not focus solely on side-effects of therapy but includes disease-related symptoms to achieve satisfactory control of symptoms in outpatients receiving chemotherapy. PMID: 22065282 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5429235 Sun, 20 Nov 2011 23:12:02 +0100 5429235 http://www.medworm.com/index.php?rid=5429234&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22072300%26dopt%3DAbstract CONCLUSIONS: Our study confirms that BNP can help physicians in identifying heart failure in patients suffering from an acute exacerbation of COPD. PMID: 22072300 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5429234 Sun, 20 Nov 2011 23:12:02 +0100 5429234 http://www.medworm.com/index.php?rid=5384363&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22030562%26dopt%3DAbstract CONCLUSIONS: Sustained injury might provide skiers and snowboards with a potent trigger to change their attitude towards the use of protective equipment. The psychological processes influencing the use of protective equipment require further investigation. PMID: 22030562 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5384363 Wed, 09 Nov 2011 00:15:02 +0100 5384363 http://www.medworm.com/index.php?rid=5384307&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22030691%26dopt%3DAbstract CONCLUSION: The participants had an appreciation of the value of records, but they did not have the relevant knowledge regarding the legal requirements for keeping records. The participants blamed a lack of time and remuneration for their failure to keep records according to known requirements. RECOMMENDATION: All practising allied health professionals should keep up-to-date and accurate records that conform to active legal requirements and existing international guidelines. In addition to the existing legal requirements, the emergence of e-health and the electronic era will trigger major changes in patient record management by physiotherapists. PMID: 22030691 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5384307 Wed, 09 Nov 2011 00:15:02 +0100 5384307 http://www.medworm.com/index.php?rid=5384306&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22052571%26dopt%3DAbstract Authors: Bohlhalter S, Kaegi G Abstract Parkinsonism refers to a neurological syndrome embracing bradykinesia, muscle rigidity, tremor at rest and impaired postural reflexes, and involving a broad differential diagnosis. Having ruled out secondary causes (most importantly drugs), distinguishing levodopa-responsive idiopathic parkinson's disease (PD) from chiefly treatment-resistant and hence atypical parkinsonism is essential. Recent clinico-pathological studies using data-driven approaches have refined the traditional classifications of parkinsonism by identifying a spectrum of subtypes with different prognoses. For example, progressive supranuclear palsy (PSP), characterised by early vertical gaze limitation and falls, probably has a milder variant with predominant parkinsonism (... Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5384306 Wed, 09 Nov 2011 00:15:02 +0100 5384306 http://www.medworm.com/index.php?rid=5384305&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22057648%26dopt%3DAbstract This article describes the example of a Swiss canton in which the legal framework enables health-care personnel to put into practice health care that is equivalent to the care available to non imprisoned persons including harm reduction measures for prisoners. The article describes the medical institutions in charge of health care for prisoners and the legal and ethical framework, its repercussions on the clinical and public health context, as well as persisting difficulties. The Geneva experience shows that in spite of the legal context, preventive measures, free informed consent and confidentiality have to be constantly defended by physicians and public health authorities. Both need to be regularly educated on their obligations towards prisoner patients. A complaint mechanism granted to ... Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5384305 Wed, 09 Nov 2011 00:15:02 +0100 5384305 http://www.medworm.com/index.php?rid=5384304&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22057669%26dopt%3DAbstract Authors: Rizzoli R, Kraenzlin M, Krieg MA, Mellinghoff HU, Lamy O, Lippuner K Abstract To prevent osteoporotic fracture occurrence, a variety of treatment regimens with different mechanisms of action is available. The antiresorptive bisphosphonate drugs are currently the most commonly prescribed agents in the management of patients with osteoporosis. The recombinant amino-terminal fragment of human parathyroid hormone (Teriparatide) is a bone anabolic agent which reduces fracture risk by increasing bone mass and improving bone microarchitecture. Teriparatide treatment reduces vertebral and non-vertebral fracture risk markedly in women and men with idiopathic osteoporosis, or with glucocorticoid-induced osteoporosis. Teriparatide should thus be considered as first line treatment for... Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5384304 Wed, 09 Nov 2011 00:15:02 +0100 5384304 http://www.medworm.com/index.php?rid=5350266&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22020555%26dopt%3DAbstract Authors: Haybäck J, Zeller N, Heikenwälder M Abstract In recent years, enormous progress has been made in identifying microRNAs (miRNAs) as important regulators of gene expression and their association with or control of various liver diseases such as fibrosis, hepatitis and hepatocellular carcinoma (HCC). Indeed, many genes encoding miRNAs as well as their targets have been described and their direct or indirect link to the respective liver diseases has been investigated in various experimental systems as well as in human tissue. Here we discuss current knowledge of miRNAs and their involvement in liver diseases, elaborating in particular on the contribution of miRNAs to hepatitis, fibrosis and HCC formation. We also debate possible prognostic, predictive and therapeutic values ... Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5350266 Thu, 27 Oct 2011 04:25:02 +0100 5350266 http://www.medworm.com/index.php?rid=5350265&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22025263%26dopt%3DAbstract Authors: Hurst S Abstract No summary available. PMID: 22025263 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5350265 Thu, 27 Oct 2011 04:25:02 +0100 5350265 http://www.medworm.com/index.php?rid=5334399&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21971666%26dopt%3DAbstract CONCLUSIONS: Implicit rationing policies introduced in Switzerland to limit healthcare costs and the number of physicians has had no impact on anaesthetists' workforce density, working conditions and overall satisfaction in Latin Switzerland. This opens the question of the real usefulness of these policies, at least for anaesthetists. PMID: 21971666 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5334399 Fri, 21 Oct 2011 15:05:03 +0100 5334399 http://www.medworm.com/index.php?rid=5334398&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21971698%26dopt%3DAbstract CONCLUSIONS: The long term use of antipsychotics in nursing homes may need to be reconsidered in view of novel treatment recommendations, suggesting that the prescription of antipsychotics for patients with dementia should be a second line treatment, restricted to symptoms of psychosis or severe aggression, and prescribed for the shortest duration possible. PMID: 21971698 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5334398 Fri, 21 Oct 2011 15:05:03 +0100 5334398 http://www.medworm.com/index.php?rid=5334397&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21971739%26dopt%3DAbstract CONCLUSION: CTA is a useful additional tool for the confirmation of the diagnosis of brain death. Pooling of contrast in the relevant cerebral vessels, however, can be detected in up to 25% of CTAs in clinically brain dead patients. PMID: 21971739 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5334397 Fri, 21 Oct 2011 15:05:03 +0100 5334397 http://www.medworm.com/index.php?rid=5334396&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21971822%26dopt%3DAbstract CONCLUSIONS: Patient safety remains a major challenge for the Swiss health care system. Despite the health related and economic burden associated with it, the widespread experience of medical error in some subpopulations also has the potential to erode trust in the health care system as a whole. PMID: 21971822 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5334396 Fri, 21 Oct 2011 15:05:03 +0100 5334396 http://www.medworm.com/index.php?rid=5334395&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21984071%26dopt%3DAbstract CONCLUSION: The extent of the consequences of high Ambrosia pollen concentrations is not ascertainable over the short term. Sensitisation rates have constantly increased over a period of more than 15 years, and moreover the incidence of allergy is delayed during the first years. PMID: 21984071 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5334395 Fri, 21 Oct 2011 15:05:03 +0100 5334395 http://www.medworm.com/index.php?rid=5334394&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21984121%26dopt%3DAbstract CONCLUSION: These results suggest that AHF patients at low, intermediate and high risk for death within 360 days can be easily identified using patient's demographics and laboratory data obtained at presentation. Application of this simple risk stratification algorithm may help to improve the management of these patients. PMID: 21984121 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5334394 Fri, 21 Oct 2011 15:05:03 +0100 5334394 http://www.medworm.com/index.php?rid=5334393&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21984183%26dopt%3DAbstract CONCLUSIONS: A shift in the causes of death significantly increased the average age of donors, and transplantation medicine is confronted with a growing number of extended criteria donors. Nevertheless, 10-year survival of transplant recipients is better than ever before. PMID: 21984183 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5334393 Fri, 21 Oct 2011 15:05:03 +0100 5334393 http://www.medworm.com/index.php?rid=5334392&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21984207%26dopt%3DAbstract CONCLUSION: Methylphenidate misuse is not a significant burden for emergency departments in Switzerland. Oral and nasal administration of methylphenidate did not result in severe toxicity. However, injection of crushed methylphenidate pills lead to serious local toxicity. Most patients with methylphenidate abuse had a prescription for the drug indicating deviation from medical use. A history of multiple substance use may be a risk factor for non-medical use of methylphenidate. PMID: 21984207 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5334392 Fri, 21 Oct 2011 15:05:03 +0100 5334392 http://www.medworm.com/index.php?rid=5334391&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21984259%26dopt%3DAbstract CONCLUSION: Despite high workload, time and economic pressure, the majority of radiologists were professionally satisfied at a high level, which had even increased within the last five years. However, to keep this level of job satisfaction, career possibilities, especially in private practices, have to be improved. Furthermore, the radiologists' important contribution to the diagnostic and therapeutic process has to be recognised professionally as well as economically. PMID: 21984259 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5334391 Fri, 21 Oct 2011 15:05:03 +0100 5334391 http://www.medworm.com/index.php?rid=5334390&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21989905%26dopt%3DAbstract CONCLUSIONS: Despite a higher prevalence of illness in patients from countries with violent conflict, the length of time spent in administrative "asylum seeker" status seemed to be the main driver of health care costs. Language barriers may be skewing results, with respect to the importance of specific diagnoses (especially mental health disorders), in driving costs upward. These results indicate a need for more comprehensive screening strategies for asylum seekers in receiving countries, particularly for those from countries in conflict. PMID: 21989905 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5334390 Fri, 21 Oct 2011 15:05:03 +0100 5334390 http://www.medworm.com/index.php?rid=5334389&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21989944%26dopt%3DAbstract CONCLUSION: The data suggest that LMW-HA produced by lung fibroblasts in response to cyclic stretch increases the secretion of IL-8 in transformed bronchial epithelial cells via AP-1 and NF-κB signalling pathways. These findings support the hypothesis that LMW-HA plays an active role in acute lung inflammation triggered by mechanical strain. PMID: 21989944 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5334389 Fri, 21 Oct 2011 15:05:03 +0100 5334389 http://www.medworm.com/index.php?rid=5334388&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21989970%26dopt%3DAbstract CONCLUSION: This study demonstrated that the intensity of 8-OHdG expression in NTc was associated with the severity of renal fibrosis. PMID: 21989970 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5334388 Fri, 21 Oct 2011 15:05:03 +0100 5334388 http://www.medworm.com/index.php?rid=5334387&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21990006%26dopt%3DAbstract CONCLUSIONS: A total of eight allergens account for 83% of IgE-mediated food allergies in Swiss infants and children, with differences in the distribution and order of the most frequently involved food allergens between paediatric age groups. PMID: 21990006 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5334387 Fri, 21 Oct 2011 15:05:03 +0100 5334387 http://www.medworm.com/index.php?rid=5334386&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21990032%26dopt%3DAbstract CONCLUSION: Although limited by small sample size, this study found that plasma copeptin level appears to add very little information to the work up of sodium imbalance in this cohort of medical inpatients. It is likely that the non-osmotic "stress"-stimulus in acute hospitalised patients is a major confounder and overrules the osmotic stimulus. PMID: 21990032 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5334386 Fri, 21 Oct 2011 15:05:03 +0100 5334386 http://www.medworm.com/index.php?rid=5334385&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22006036%26dopt%3DAbstract Authors: Tanriverdi O, Cetin D Abstract No abstract available. PMID: 22006036 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5334385 Fri, 21 Oct 2011 15:05:03 +0100 5334385 http://www.medworm.com/index.php?rid=5334384&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22006068%26dopt%3DAbstract Authors: Yavas O Abstract No abstract available. PMID: 22006068 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5334384 Fri, 21 Oct 2011 15:05:03 +0100 5334384 http://www.medworm.com/index.php?rid=5334383&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22006114%26dopt%3DAbstract Authors: Amirkhosravi A, Meyer T, Francis JL Abstract No abstract available. PMID: 22006114 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5334383 Fri, 21 Oct 2011 15:05:03 +0100 5334383 http://www.medworm.com/index.php?rid=5334382&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22006164%26dopt%3DAbstract Reply to the letter to the editor "Assessing the role of platelet activation in bevacizumab associated thrombosis" Swiss Med Wkly. 2011;141:w13279 Authors: Reinhart WH, Fehr M, von Moos R Abstract No abstract available. PMID: 22006164 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5334382 Fri, 21 Oct 2011 15:05:03 +0100 5334382 http://www.medworm.com/index.php?rid=5334381&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22009704%26dopt%3DAbstract CONCLUSION: Genetic polymorphisms of GSTP1 and XRCC1 may be important predictive factors in platinum-treated patients with advanced NSCLC. Assessment of genetic variations of GSTP1 and XRCC1 could facilitate therapeutic decisions for individualised therapy in advanced NSCLC. PMID: 22009704 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5334381 Fri, 21 Oct 2011 15:05:03 +0100 5334381 http://www.medworm.com/index.php?rid=5334380&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22009720%26dopt%3DAbstract Authors: Berger TM, Bernet V, El Alama S, Fauchère JC, Hösli I, Irion O, Kind C, Latal B, Nelle M, Pfister RE, Surbek D, Truttmann AC, Wisser J, Zimmermann R Abstract Perinatal care of pregnant women at high risk for preterm delivery and of preterm infants born at the limit of viability (22-26 completed weeks of gestation) requires a multidisciplinary approach by an experienced perinatal team. Limited precision in the determination of both gestational age and foetal weight, as well as biological variability may significantly affect the course of action chosen in individual cases. The decisions that must be taken with the pregnant women and on behalf of the preterm infant in this context are complex and have far-reaching consequences. When counselling pregnant women and their part... Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5334380 Fri, 21 Oct 2011 15:05:03 +0100 5334380 http://www.medworm.com/index.php?rid=5334379&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22009758%26dopt%3DAbstract CONCLUSIONS: The cantonal rules of implementation and the size of the health care institutions play an important role in these courses for women in French-speaking Switzerland. PMID: 22009758 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5334379 Fri, 21 Oct 2011 15:05:03 +0100 5334379 http://www.medworm.com/index.php?rid=5334378&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22012428%26dopt%3DAbstract Authors: Lalive AL, Rudolph U, Lüscher C, Tan KR Abstract Benzodiazepines are widely prescribed drugs used to treat anxiety and insomnia, induce muscle relaxation, control epileptic seizures, promote anaesthesia or produce amnesia. Benzodiazepines are also abused for recreational purposes and the number of benzodiazepine abusers is unfortunately increasing. Within weeks of chronic use, tolerance to the pharmacological effects can develop and withdrawal becomes apparent once the drug is no longer available, which are both conditions indicative of benzodiazepine dependence. Diagnosis of addiction (i.e. compulsive use despite negative consequences) may follow in vulnerable individuals. Here, we review the historical and current use of benzodiazepines from their original synthesis, di... Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5334378 Fri, 21 Oct 2011 15:05:03 +0100 5334378 http://www.medworm.com/index.php?rid=5334377&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22012483%26dopt%3DAbstract CONCLUSIONS: One-third of children with AIS were diagnosed within six hours. Diagnostic delay was predominately caused by insufficient recognition of stroke symptoms. Increased public and expert awareness and immediate access to diagnostic imaging are essential. The ability of parents/caregivers and health professionals to recognise stroke symptoms in a child needs to be improved. PMID: 22012483 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5334377 Fri, 21 Oct 2011 15:05:03 +0100 5334377 http://www.medworm.com/index.php?rid=5334376&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22012547%26dopt%3DAbstract Authors: Wagner B, Boucsein V, Maercker A Abstract In Switzerland, all deaths through assisted suicide are reported as unnatural deaths and investigated by a forensic team (police, medical examiner, and state attorney). However, there is limited knowledge concerning the impact these forensic investigations have on the development of post-traumatic stress disorder, complicated grief, or depression in those who have lost a loved one. A cross-sectional survey of 85 family members or close friends who were present at an assisted suicide was conducted in December 2007. The Impact of Event Scale, Inventory of Complicated Grief, and Brief Symptom Inventory were used to assess mental health. The newly developed Forensic Investigation Experience Scale measured the emotional experience of th... Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5334376 Fri, 21 Oct 2011 15:05:03 +0100 5334376 http://www.medworm.com/index.php?rid=5285301&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21956650%26dopt%3DAbstract Authors: Kesten F, Aschwanden M, Gubser P, Glatz K, Daikeler T, Hess C Abstract Giant cell arteriitis (GCA) is the most common of the vasculitis syndromes and, being a disease of the elderly, its incidence is increasing with the general ageing of the population. GCA is most feared for its early complications, namely blindness and stroke, resulting from inflammation and subsequent occlusion of ocular and extra cranial arteries, respectively. More recently, however, GCA has been recognised to also affect limb arteries and the aorta with a high prevalence. These newly recognised features of GCA pose diagnostic, therapeutic and prognostic challenges to treating physicians. Here, recent developments in the field of GCA are summarised and discussed. PMID: 21956650 [PubMed - in proces... Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5285301 Thu, 06 Oct 2011 01:20:01 +0100 5285301 http://www.medworm.com/index.php?rid=5285300&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21956677%26dopt%3DAbstract Authors: Sutherland K, Cistulli P Abstract Oral devices, in particular Mandibular Advancement Splints (MAS), which hold the mandible in a protruded position during sleep, are increasingly used for the treatment of Obstructive Sleep Apnoea (OSA). These devices can be effective in treating OSA across a range of severity. Complete resolution of OSA (Apnoea-Hypopnoea Index [AHI] reduced <5/hr) with use of an MAS occurs in around 40% of patients. Overall two thirds of patients experience some clinical benefit (≥50% AHI reduction AHI) however others will not objectively respond to this form of treatment, despite improvement in symptoms. Although MAS are less efficacious in reducing polysomnographic indices of OSA than the standard treatment, Continuous Positive Airway Pressure (CPAP... Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5285300 Thu, 06 Oct 2011 01:20:01 +0100 5285300 http://www.medworm.com/index.php?rid=5223174&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21901650%26dopt%3DAbstract Authors: Probst-Hensch N, Tanner M, Kessler C, Burri C, Künzli N Abstract The United Nations General Assembly has convened a Summit on non-communicable diseases (NCDs), an historic moment in the global combat of these disorders. Lifestyles in increasingly urban and globalised environments have led to a steep surge in NCD incidence in low and middle income countries, where two thirds of all NCD deaths occur (most importantly from cancer, cardiovascular and respiratory disease as well as diabetes). Treatment of NCDs is usually long term and expensive, thus threatening patients' and nations' budgets and putting them at high risk for poverty. The NCD Summit offers an opportunity for strengthening and shaping primary prevention, the most cost-effective instrument to fight major risk fa... Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5223174 Fri, 16 Sep 2011 10:20:02 +0100 5223174 http://www.medworm.com/index.php?rid=5223173&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21904992%26dopt%3DAbstract Authors: Wicki A, Hagmann J Abstract Large claims have been made for the effectiveness of particular diets in preventing cancer or inhibiting its progression. However, more recent clinical studies have not confirmed this. Instead it seems that rather than specific dietary constituents, total calories influence cancer incidence and progression. In this review article, we summarise and interpret the available evidence for links between diet and cancer. PMID: 21904992 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5223173 Fri, 16 Sep 2011 10:20:02 +0100 5223173 http://www.medworm.com/index.php?rid=5223172&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21913139%26dopt%3DAbstract Authors: Negro F Abstract Since the publication in 2009 of clinical practice guidelines for the management of hepatitis B virus (HBV) infection by the European Association for the Study of the Liver (EASL), a wealth of new data has emerged regarding the antivirals most commonly used to treat chronic hepatitis B. This review will summarise the most recent knowledge on these drugs, and how this may affect current and future management of HBV infection. Despite the progress in drug development, HBV infection remains a complex entity, characterised by a peculiar interplay between host and viral factors. With the potent drugs currently available, however, its management and control are possible in the majority of cases. PMID: 21913139 [PubMed - in process] (Source: Swiss Medical Wee... Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5223172 Fri, 16 Sep 2011 10:20:02 +0100 5223172 http://www.medworm.com/index.php?rid=5197534&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21882122%26dopt%3DAbstract Authors: Meier C, Kränzlin M Abstract Adequate intakes of calcium and vitamin D are essential preventive strategies and essential parts of any therapeutic regimen for osteoporosis. However, calcium supplementation is not without controversy and benefits on skeletal health need to be balanced against potential risks on cardiovascular disease. The published data so far suggest a potential detrimental effect of calcium supplement on cardiovascular health (i.e. myocardial infarction) although further prospective studies are needed to clarify the gradient of risk. Since food sources of calcium produce similar benefits on bone density as supplements and dietary calcium intake does not seem to be related with adverse cardiovascular effects, calcium intake from nutritional sources needs t... Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5197534 Wed, 07 Sep 2011 13:40:03 +0100 5197534 http://www.medworm.com/index.php?rid=5197533&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21882123%26dopt%3DAbstract Authors: Pfisterer M, Nietlispach F, Jeger R, Kaiser C Abstract In this review of the BAsel Stent Kosten-Effektivitäts Trial (BASKET) the trials and their impact on coronary stenting practice were examined, basing the clinical questions of each study on the findings of the previous study. Are the new drug-eluting stents (DES) cost-effective compared to standard bare-metal stents (BMS) if used in all patients? No. Are there specific subgroups of patients with a particular benefit? Yes. A "targeted stent use" was proposed for daily practice. What is the long-term safety of DES? Unexpected safety problems were observed. Was this a chance finding? No. However, with improved stenting techniques, newer stents and intensified antiplatelet regimens late problems were minimised as shown in... Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5197533 Wed, 07 Sep 2011 13:40:03 +0100 5197533 http://www.medworm.com/index.php?rid=5180628&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21877298%26dopt%3DAbstract Authors: Pisetsky D Abstract Cell death is a ubiquitous process whose immunological consequences can influence the course of infectious, autoimmune and inflammatory diseases. While cell death has long been dichotomised in terms of apoptosis and necrosis, other forms of death can occur and they vary in their capacity to stimulate as well as inhibit inflammation. The pro-inflammatory activity of dead cells results from a wide variety of intracellular molecules that are released as cell permeability increases during death. These molecules have been termed as DAMPs (damage associated molecular patterns) or alarmins. Among these DAMPs, HMGB1, a non-histone nuclear protein, serves as the prototype. Although HMGB1 was originally thought to act alone as a cytokine, recent studies suggest t... Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5180628 Fri, 02 Sep 2011 09:36:02 +0100 5180628 http://www.medworm.com/index.php?rid=5163904&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21557111%26dopt%3DAbstract Authors: Dudler J, Möller B, Michel BA, Villiger PM Abstract The new paradigm of therapy in rheumatoid arthritis is to aim toward early and complete remission, using a larger use of conventional DMARDs and biologic agents. The present recommendations were established through a consensus to help practitioners in their daily use of those agents, to reflect the current "best practice" in Switzerland. PMID: 21557111 [PubMed - indexed for MEDLINE] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5163904 Sat, 27 Aug 2011 17:08:03 +0100 5163904 http://www.medworm.com/index.php?rid=5163903&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21574067%26dopt%3DAbstract CONCLUSION: Persistent dyslipidemia is a reality in statin-treated patients and may contribute to their residual cardiovascular risk. Therefore, comprehensive lipid management should be preferred to aggressive LDL-C lowering alone. Moreover, strategies to assess and modify the global cardiovascular risk of patients should be taken into account as an important component of primary and secondary prevention. PMID: 21574067 [PubMed - indexed for MEDLINE] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5163903 Sat, 27 Aug 2011 17:08:03 +0100 5163903 http://www.medworm.com/index.php?rid=5163902&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21870299%26dopt%3DAbstract CONCLUSIONS: In line with published data, sensitivity to previous chemotherapy identifies Caucasian patients who will survive the longest following second-line chemotherapy. A low tumour burden and previous curative gastrectomy also seem to have a positive prognostic value. PMID: 21870299 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5163902 Sat, 27 Aug 2011 17:08:03 +0100 5163902 http://www.medworm.com/index.php?rid=5163901&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21870300%26dopt%3DAbstract CONCLUSION: Complete surgical resection, septum included, was the treatment of choice and mandatory to prevent relapse. Peri-operative morbidity and mortality over 40 years remained low, and no association between HSV infection and occurrence of cardiac myxoma was found. PMID: 21870300 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5163901 Sat, 27 Aug 2011 17:08:03 +0100 5163901 http://www.medworm.com/index.php?rid=5163900&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21870301%26dopt%3DAbstract CONCLUSION: Propofol sedation for flexible bronchoscopy is feasible and safe. PMID: 21870301 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5163900 Sat, 27 Aug 2011 17:08:03 +0100 5163900 http://www.medworm.com/index.php?rid=5145263&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21842451%26dopt%3DAbstract CONCLUSIONS: A surgical clerkship might have a positive impact on the choice of a surgical career. As there might be a shortage of surgeons in the future, lifestyle as the main impediment for choosing a surgical career should be kept in mind. PMID: 21842451 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5145263 Sat, 20 Aug 2011 17:24:02 +0100 5145263 http://www.medworm.com/index.php?rid=5145262&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21842452%26dopt%3DAbstract CONCLUSION: A 4-month RIF treatment was associated with significantly less interruption of treatment because of hepatotoxicity and higher completion rates compared to a 6-month INH regimen. These results support the RIF regimen as an alternative to the presently recommended 9 months of INH in clinical practice. PMID: 21842452 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5145262 Sat, 20 Aug 2011 17:24:02 +0100 5145262 http://www.medworm.com/index.php?rid=5119583&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21528463%26dopt%3DAbstract Authors: Bürge E, Berchtold A, von Gunten A The aim of this paper was to establish gender-specific associations between the characteristics of residents recently admitted to Swiss nursing homes (NH) and their activities of daily living (ADL) performance. PMID: 21528463 [PubMed - indexed for MEDLINE] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5119583 Fri, 12 Aug 2011 14:45:03 +0100 5119583 http://www.medworm.com/index.php?rid=5119582&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21528465%26dopt%3DAbstract Authors: Tritschler T, Sennhauser FH, Frey B Racial and ethnic disparities in health care are significant predictors of the quality of health care received. Studies documenting these disparities are largely based on an adult chronic care model. There are only few reports in paediatric populations. Our objective was to evaluate the severity of illness of immigrants at admission to PICU, the proportion of immigrants in PICU compared to the general population and the quality of care they receive, in order to examine whether there are disparities in health care. PMID: 21528465 [PubMed - indexed for MEDLINE] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5119582 Fri, 12 Aug 2011 14:45:03 +0100 5119582 http://www.medworm.com/index.php?rid=5119581&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21800264%26dopt%3DAbstract Authors: Hoke M, Schillinger T, Mlekusch W, Wagner O, Minar E, Schillinger M Dental status and oral hygiene are associated with progression of atherosclerosis in patients with carotid stenosis. It remains unclear whether dental disease is a risk factor for mortality in these patients. We evaluated the bearing of dental disease on mortality among patients with asymptomatic carotid atherosclerosis. PMID: 21800264 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5119581 Fri, 12 Aug 2011 14:45:03 +0100 5119581 http://www.medworm.com/index.php?rid=5119580&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21805405%26dopt%3DAbstract Authors: Fehr M, Catschegn S, Reinhart WH, Madon J, Asmis L, Cathomas R, von Moos R Systemic treatment with bevacizumab is associated with increased rates of arterial and venous thromboembolism and haemorrhage. In order to investigate the pathophysiological mechanism involved, platelet adhesive and aggregatory functions were tested with a platelet function analyser (PFA-100®) in an in vitro study and in a longitudinal clinical observation study. For the in vitro study, blood from ten healthy volunteers was incubated with different concentrations of bevacizumab (0-1000 μg/ml plasma) and vascular endothelial growth factor (0-500 μg/ml). In the clinical observation study, PFA-100® closure times (CTs) and soluble P-selectin (sP-selectin) serum levels as a serological marker of platelet... Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5119580 Fri, 12 Aug 2011 14:45:03 +0100 5119580 http://www.medworm.com/index.php?rid=5119579&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21805406%26dopt%3DAbstract Authors: Otth M, Rödder S, Immer FF, Marti HP The widening gap between the numbers of patients on the waiting list for organ transplantation and the insufficient numbers of organ donors results in the use of "critical" donors, so-called marginal donors or extended criteria donors. Data concerning the evaluation of extended criteria donors (ECD) in Switzerland are sparse. PMID: 21805406 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5119579 Fri, 12 Aug 2011 14:45:03 +0100 5119579 http://www.medworm.com/index.php?rid=5119578&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21805407%26dopt%3DAbstract Authors: Koçer O, Wachter M, Zellweger M, Piazzalonga S, Hoffmann A Depression is an important independent prognostic variable in cardiac patients. The prevalence and predictors of depressive symptoms up to nine years after cardiac rehabilitation were studied. PMID: 21805407 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5119578 Fri, 12 Aug 2011 14:45:03 +0100 5119578 http://www.medworm.com/index.php?rid=5119577&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21805408%26dopt%3DAbstract We describe our current triage practice and assess the potential of a combination of CURB65 with proadrenomedullin (ProADM) levels for triage decisions. PMID: 21805408 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5119577 Fri, 12 Aug 2011 14:45:03 +0100 5119577 http://www.medworm.com/index.php?rid=5119576&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21805409%26dopt%3DAbstract Authors: Staub K, Rühli F, Woitek U, Pfister C We determine the causes of secular changes in the average height of the male Swiss population for the first time by analysing an unbiased, individually measured, highly representative height-data sample of 18- and 19-year-old Swiss conscripts (N = 458,322) at the national level spanning the years 1992 to 2009. Furthermore, we add historical context based on earlier data from the same source. PMID: 21805409 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5119576 Fri, 12 Aug 2011 14:45:03 +0100 5119576 http://www.medworm.com/index.php?rid=5119575&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21805410%26dopt%3DAbstract Authors: Fateh R, Iravani S, Frootan M, Rasouli MR, Saadat S Evaluating the effects of a commercially available synbiotic preparation (contains both prebiotic and probiotic elements) on functional constipation in males. PMID: 21805410 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5119575 Fri, 12 Aug 2011 14:45:03 +0100 5119575 http://www.medworm.com/index.php?rid=5119574&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21815111%26dopt%3DAbstract This article presents an overview of the current therapeutic strategies for the management of follicular lymphoma, focusing on the issues encountered in clinical practice. PMID: 21815111 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5119574 Fri, 12 Aug 2011 14:45:03 +0100 5119574 http://www.medworm.com/index.php?rid=5071532&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21769753%26dopt%3DAbstract Authors: Schaub N, Frei R, Müller C The incidence of sepsis and the number of sepsis-related deaths are increasing, making sepsis the leading cause of death in critically ill patients in Europe and the U.S.A. Delayed recognition of sepsis and inappropriate initial antibiotic therapy are associated with an increase in mortality and morbidity. Rapid and accurate identification of sepsis and its causative organisms are a prerequisite for successful therapy. The current gold standard for the diagnosis of sepsis is culture of blood and other body fluids or tissues. However, even in severe sepsis, blood cultures (BC) yield the causative microorganism in only 20-40% of patients. Moreover, at least 24 hours are needed to get preliminary information about the potential organism. Therefore, nov... Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5071532 Fri, 29 Jul 2011 06:15:02 +0100 5071532 http://www.medworm.com/index.php?rid=5071531&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21769754%26dopt%3DAbstract Authors: Kaderli R, Muff B, Stefenelli U, Businger A An increasing proportion of women are working in medicine, although only very few choose surgical specialties and the interest in an academic pursuit is generally smaller among women compared to their male colleagues. The aim of the present study was to analyse factors critical for a successful academic career for female surgeons in Switzerland and to assess the value of mentor-mentee relationships in this context. PMID: 21769754 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5071531 Fri, 29 Jul 2011 06:15:02 +0100 5071531 http://www.medworm.com/index.php?rid=5071530&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21769755%26dopt%3DAbstract Authors: Bao YS, Xie RJ, Wang M, Feng SZ, Han MZ Patients undergoing myeloablative allogeneic haematopoietic stem cell transplantation (HSCT) have a higher incidence of acute kidney injury (AKI). RIFLE is a newly developed classification for AKI that includes three grades of severity - AKI-R, AKI-I, AKI-F. PMID: 21769755 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5071530 Fri, 29 Jul 2011 06:15:02 +0100 5071530 http://www.medworm.com/index.php?rid=5071529&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21769756%26dopt%3DAbstract Authors: Haller DM, Steiner AS, Sebo P, Gaspoz JM, Wolff H Young offenders represent a group for which Chlamydia trachomatis infection screening is recommended in the US. In the absence of local epidemiological data it is difficult to assess whether such recommendations apply to the Swiss context. Our aim was to obtain local prevalence data for Chlamydia trachomatis infection among young male offenders as a basis for screening strategies in Swiss juvenile detention centres. PMID: 21769756 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5071529 Fri, 29 Jul 2011 06:15:02 +0100 5071529 http://www.medworm.com/index.php?rid=5071528&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21769757%26dopt%3DAbstract Authors: Schuetz P, Albrich WC, Suter I, Hug BL, Christ-Crain M, Holler T, Henzen C, Krause M, Schoenenberger R, Zimmerli W, Mueller B Reimbursement for inpatient treatment in Switzerland is in transition. While hospitals in some cantons already use Diagnosis Related Groups (DRG) based systems for hospital financing, others use fee-for-service (FFS) based systems, a situation that provides the opportunity to perform a head-to-head comparison between the two reimbursement systems. The aim of this analysis was to compare reimbursement systems with regard to length of hospital stay (LOS) and patient outcomes in a cohort of community-acquired pneumonia patients from a previous prospective multicentre study in Switzerland. PMID: 21769757 [PubMed - in process] (Source: Swiss Medical Week... Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5071528 Fri, 29 Jul 2011 06:15:02 +0100 5071528 http://www.medworm.com/index.php?rid=5071527&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21780008%26dopt%3DAbstract Authors: Stover J Therapeutic interventions following severe traumatic brain injury (TBI) are substantially influenced by complex and interwoven pathophysiological cascades involving both, local and systemic alterations. Our main duty is to prevent secondary progression of the primary damage. This, in turn, obliges us to actively search and identify secondary insults related, for example, to hypoxia, hypotension, uncontrolled hyperventilation, anaemia, and hypoglycaemia. During pharmacological coma we must rely on specific cerebral monitoring which is indispensable in unmasking otherwise occult changes. In addition, extended neuromonitoring (SjvO2, ptiO2, microdialysis, transcranial Doppler sonography, electrophysiological studies, direct brain perfusion measurement) can be used to def... Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5071527 Fri, 29 Jul 2011 06:15:02 +0100 5071527 http://www.medworm.com/index.php?rid=5025400&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21720967%26dopt%3DAbstract Authors: Aeberli I, Gut-Knabenhans M, Kusche-Ammann RS, Molinari L, Zimmermann MB Central obesity, measured as waist circumference (WC), is an important risk factor for cardiovascular disease and diabetes already in children. The ratio of waist circumference to height (WHtR) is a further indicator for body shape. International reference values, however, do not exist for any of the two measures and neither do references specific to Switzerland. The aim of this study therefore was to develop WC and WHtR percentiles from a nationally representative sample of Swiss children. PMID: 21720967 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5025400 Thu, 14 Jul 2011 15:30:20 +0100 5025400 http://www.medworm.com/index.php?rid=5025399&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21720968%26dopt%3DAbstract Authors: Adam A, Faouzi M, Gaume J, Gmel G, Daeppen JB, Bertholet N To determine whether first alcohol intoxication before the age of 15 is associated with risky drinking patterns [Weekly Risky Drinking (WRD) and Binge Drinking (BD)], tobacco use, cannabis use at age 20 and other illicit substance use at somepoint within their lifetime. PMID: 21720968 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5025399 Thu, 14 Jul 2011 15:30:20 +0100 5025399 http://www.medworm.com/index.php?rid=5025398&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21720969%26dopt%3DAbstract Authors: Ezzat WF, Fawaz SA, Farid SM To determine the prevalence of primary nocturnal enuresis in children, to define the possible role of sleep-disordered breathing (SDB) related to adenotonsillar hypertrophy in enuresis, to explore the role of brain natriuretic peptide (BNP) levels in measuring the severity of SDB in enuretic children, and to evaluate the response to surgical interventions (adenotonsillectomy) in indicated enuretic patients. PMID: 21720969 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5025398 Thu, 14 Jul 2011 15:30:20 +0100 5025398 http://www.medworm.com/index.php?rid=5025397&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21720970%26dopt%3DAbstract Authors: Osterwalder JJ, Braun D High quality chest compression is one of the key factors in successful resuscitation. A high standard of training is therefore decisive. We aimed to investigate the strengths and weaknesses of teaching chest compression in a study designed to highlight where targeted improvements in the quality of our chest compression training can and must be made. PMID: 21720970 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5025397 Thu, 14 Jul 2011 15:30:20 +0100 5025397 http://www.medworm.com/index.php?rid=5025396&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21720971%26dopt%3DAbstract In conclusion, this programme highlights insufficient awareness of venous thromboembolic disease in Switzerland, underestimation of its burden and inconsistent application of international consensus statement guidelines regarding prophylaxis and treatment adopted by the Swiss Expert Group. PMID: 21720971 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5025396 Thu, 14 Jul 2011 15:30:20 +0100 5025396 http://www.medworm.com/index.php?rid=5025395&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21735362%26dopt%3DAbstract Authors: Hegar K, Heiber S, Braendle M, Christ E, Keller U Carbohydrate counting is a principal strategy in nutritional management of type 1 diabetes. The Nutri-Learn buffet (NLB) is a new computer-based tool for patient instruction in carbohydrate counting. It is based on food dummies made of plastic equipped with a microchip containing relevant food content data. The tool enables the dietician to assess the patient's food counting abilities and the patient to learn in a hands-on interactive manner to estimate food contents such as carbohydrate content. PMID: 21735362 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5025395 Thu, 14 Jul 2011 15:30:20 +0100 5025395 http://www.medworm.com/index.php?rid=5025394&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21735363%26dopt%3DAbstract Authors: Gojanovic B, Feihl F, Liaudet L, Gremion G, Waeber B Whole body vibration (WBV) is an increasingly popular modality of muscle training, especially in sedentary subjects. We hypothesised that the vigorous muscle contractions elicited by WBV can cause muscle damage expressed as an elevation in muscle enzymes. PMID: 21735363 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5025394 Thu, 14 Jul 2011 15:30:20 +0100 5025394 http://www.medworm.com/index.php?rid=5025393&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21735364%26dopt%3DAbstract Authors: Gerber PA, Spirk D, Brändle M, Thoenes M, Lehmann R, Keller U We investigated contemporary diabetes care, quality of glycaemic control, and progression of obesity in patients with diabetes mellitus in different cultural regions within Switzerland. PMID: 21735364 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5025393 Thu, 14 Jul 2011 15:30:20 +0100 5025393 http://www.medworm.com/index.php?rid=5025392&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21735365%26dopt%3DAbstract Authors: Schmid P, Mordasini A, Luginbühl M, Regli B, Kohler HP, Zimmermann H, Inderbitzin D, Hirt A, Lämmle B, Alberio L recombinant activated factor VII (rFVIIa) is used off-label for massive bleeding. There is no convincing evidence of the benefits of this practice and the minimal effective dose is unknown. The aim of the study was to evaluate our in-house guideline recommending a low dose of 60 μg/kg for off-label use of rFVIIa. PMID: 21735365 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5025392 Thu, 14 Jul 2011 15:30:20 +0100 5025392 http://www.medworm.com/index.php?rid=5025391&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21735366%26dopt%3DAbstract Authors: Witteck A, Rettenmund G, Schlegel M To prospectively evaluate new guidelines for MRSA admission screening and pre-emptive isolation implemented in response to a doubling of newly diagnosed MRSA patients in 2007. PMID: 21735366 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=5025391 Thu, 14 Jul 2011 15:30:20 +0100 5025391 http://www.medworm.com/index.php?rid=4976663&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21243547%26dopt%3DAbstract Authors: Seitz M, Reichenbach S, Bonel HM, Adler S, Wermelinger F, Villiger PM To evaluate the effect of IL-6 blockade using tocilizumab in inducing remission of arterial large vessel vasculitides (LVV). PMID: 21243547 [PubMed - indexed for MEDLINE] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=4976663 Wed, 29 Jun 2011 08:00:04 +0100 4976663 http://www.medworm.com/index.php?rid=4976662&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21279859%26dopt%3DAbstract Authors: Leone MA, Ivashynka AV, Tonini MC, Bogliun G, Montano V, Ravetti C, Gambaro P, Paladin F, Beghi E, The risk of seizures increases in patients with brain tumours (BT) and brain vascular malformations (BVM), but not all risk factors are known. We aimed to identify factors that increase the risk of a first seizure in patients with BT or BVM. PMID: 21279859 [PubMed - indexed for MEDLINE] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=4976662 Wed, 29 Jun 2011 08:00:04 +0100 4976662 http://www.medworm.com/index.php?rid=4976661&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21337174%26dopt%3DAbstract Authors: Banz VM, Paul K, de Moya M, Zimmermann H, Candinas D, Exadaktylos AK Patients suffering from chronic pain have a high prevalence of depression, resulting in a significant impact on overall quality of life. Our aim was to investigate how long term acute non-specific abdominal pain (NSAP) affected overall physical and mental well-being in patients admitted to our emergency department (ED). PMID: 21337174 [PubMed - indexed for MEDLINE] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=4976661 Wed, 29 Jun 2011 08:00:04 +0100 4976661 http://www.medworm.com/index.php?rid=4976660&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21701988%26dopt%3DAbstract Authors: Karsen H, Koruk ST, Karahocagil MK, Calisir C, Baran FC The purpose is to determine the cut-off value of adenosine deaminase (ADA) activity in cerebrospinal fluid (CSF) of patients with tuberculous and non-tuberculous meningitis, and to assess its value in differential diagnosis. PMID: 21701988 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=4976660 Wed, 29 Jun 2011 08:00:04 +0100 4976660 http://www.medworm.com/index.php?rid=4976659&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21706449%26dopt%3DAbstract Authors: Gétaz L, Rieder JP, Siegrist CA, Kramer MC, Stoll B, Humair JP, Kossovsky MP, Gaspoz JM, Wolff H Measles persists worldwide despite the implementation of general vaccination campaigns. The environmental and demographic characteristics in many prisons increase the risk of measles epidemics. A large proportion of inmates come from countries where immunisation coverage is low. We aimed to estimate the susceptibility to measles among prisoners in order to implement preventative measures. PMID: 21706449 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=4976659 Wed, 29 Jun 2011 08:00:04 +0100 4976659 http://www.medworm.com/index.php?rid=4976658&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21706450%26dopt%3DAbstract Authors: Bajwa NM, Berner M, Worley S, Pfister RE To provide population-based, gestational age (GA) stratified incidence of mortality and morbidities. PMID: 21706450 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=4976658 Wed, 29 Jun 2011 08:00:04 +0100 4976658 http://www.medworm.com/index.php?rid=4976657&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21706451%26dopt%3DAbstract Authors: Chau I, Korb-Savoldelli V, Trinquart L, Caruba T, Prognon P, Durieux P, Piketty C, Sabatier B Several studies have shown that patients' inappropriate knowledge about their medication is associated with non-adherence. The aim of this study was to assess immunocompromised inpatient knowledge of their oral drug treatment on discharge. PMID: 21706451 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=4976657 Wed, 29 Jun 2011 08:00:04 +0100 4976657 http://www.medworm.com/index.php?rid=4976656&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21706452%26dopt%3DAbstract Authors: Fang L, Barekati Z, Zhang B, Liu Z, Zhong XY Breast cancer is the most commonly diagnosed malignancy and one of the major causes of death among women. Breast cancer is also one of the most investigated diseases but whose biological features are still not well understood, several effective treating strategies having been explored in dealing with different types of advanced breast cancer, such as endocrine therapy and molecular targeted therapy. Trastuzumab is the first approved targeted anti-cancer agent to show an attractive response rate and outcomes in treating HER-2 positive metastatic breast cancer patients. However, primary or acquired trastuzumab resistance usually occurs some time into the use of trastuzumab and leads to treatment resistance or tumour progression. The p... Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=4976656 Wed, 29 Jun 2011 08:00:04 +0100 4976656 http://www.medworm.com/index.php?rid=4976655&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21706453%26dopt%3DAbstract Authors: Manz M, Michetti P, Seibold F, Rogler G, Beglinger C The care for a patient with ulcerative colitis (UC) remains challenging despite the fact that morbidity and mortality rates have been considerably reduced during the last 30 years. The traditional management with intravenous corticosteroids was modified by the introduction of ciclosporin and infliximab. In this review, we focus on the treatment of patients with moderate to severe UC. Four typical clinical scenarios are defined and discussed in detail. The treatment recommendations are based on current literature, published guidelines and reviews, and were discussed at a consensus meeting of Swiss experts in the field. Comprehensive treatment algorithms were developed, aimed for daily clinical practice. PMID: 21706453 [Pu... Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=4976655 Wed, 29 Jun 2011 08:00:04 +0100 4976655 http://www.medworm.com/index.php?rid=4927800&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21630161%26dopt%3DAbstract Authors: Khanfir K, Elhfidh M, Anchisi S, Matzinger O, Bieri S, Mirimanoff RO, Ozsahin M, Zouhair A Chemotherapy (CT) combined with radiation therapy (RT) is the standard treatment for limited disease small-cell lung cancer (LDSCLC). Many questions including RT dose, fractionation, and sequence of RT/CT administration remain controversial. In this paper, we retrospectively assessed the outcome of patients with LDSCLC treated with radiation of at least 50 Gy. PMID: 21630161 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=4927800 Wed, 15 Jun 2011 01:00:03 +0100 4927800 http://www.medworm.com/index.php?rid=4927799&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21630162%26dopt%3DAbstract Authors: Reverdin S, Schnetzler B, Gagneux G, Gavignet C, Boehlen F, de Moerloose P INR self-testing devices allow patients on vitamin K antagonists (VKA) to determine their INR and then have their VKA dose adapted by a physician (INR self-testing, ST) or adapt it themselves according to pre-established guidelines (INR self-management, SM). The safety, efficacy and advantages of ST and SM have been demonstrated, but their use remains limited. In an effort to improve the availability of ST and SM, we tested the hypothesis that implementing a teaching programme for ST and SM in a small structure in common ambulatory private practice is feasible, safe and can lead to high patient satisfaction. PMID: 21630162 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=4927799 Wed, 15 Jun 2011 01:00:03 +0100 4927799 http://www.medworm.com/index.php?rid=4927798&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21630163%26dopt%3DAbstract Authors: Samaras P, Blickenstorfer M, Haile SR, Siciliano D, Petrausch U, Mischo A, Zweifel M, Honegger H, Schanz U, Stüssi G, Taverna C, Bauer S, Knuth A, Stenner-Liewen F, Renner C High-dose chemotherapy with subsequent autologous stem cell transplantation (ASCT) is an important treatment option in younger patients with multiple myeloma (MM). We analysed the outcome of patients treated at our institution outside the clinical trials framework and tried to identify risk factors prognostic for survival. PMID: 21630163 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=4927798 Wed, 15 Jun 2011 01:00:03 +0100 4927798 http://www.medworm.com/index.php?rid=4927797&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21630164%26dopt%3DAbstract Authors: Yao J, An Y, Wie JS, Ji ZL, Lu ZP, Wu JL, Jiang KR, Chen P, Xu ZK, Miao Y The hedgehog (Hh) pathway has been implicated in the pathogenesis of cancer including pancreatic ductal adenocarcinoma (PDAC). Recent studies have suggested that Hh plays an important role in maintaining the cancer stem cell (CSCs) pool. Gemcitabine-resistant pancreatic cancer cells highly express some of the CSCs markers. However, the expression level of Hh members in gemcitabine-resistant pancreatic cancer cells remains unknown. The aim of this study was to verify the expression of HH members, such as Shh, Ptc, SMO and Gli-1 in gemcitabine-resistant PDAC cell lines, and to explore a new strategy to overcome chemoresistance in PDAC. PMID: 21630164 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=4927797 Wed, 15 Jun 2011 01:00:03 +0100 4927797 http://www.medworm.com/index.php?rid=4881851&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21607881%26dopt%3DAbstract Authors: Vassalli G, Moccetti T Over the past decade, use of autologous bone marrow-derived mononuclear cells (BMCs) has proven to be safe in phase-I/II studies in patients with myocardial infarction (MI). Taken as a whole, results support a modest yet significant improvement in cardiac function in cell-treated patients. Skeletal myoblasts, adipose-derived stem cells, and bone marrow-derived mesenchymal stem cells (MSCs) have also been tested in clinical studies. MSCs expand rapidly in vitro and have a potential for multilineage differentiation. However, their regenerative capacity decreases with aging, limiting efficacy in old patients. Allogeneic MSCs offer several advantages over autologous BMCs; however, immune rejection of allogeneic cells remains a key issue. As human MSCs do not... Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=4881851 Tue, 31 May 2011 19:46:35 +0100 4881851 http://www.medworm.com/index.php?rid=4881850&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21607882%26dopt%3DAbstract Authors: Weller M Glioblastomas (World Health Organisation (WHO) grade IV) and anaplastic gliomas (astrocytomas, oligoastrocytomas, oligodendrogliomas) (WHO grade III) are collectively referred to as malignant gliomas. The diagnosis of malignant glioma may be suspected based on clinical history and neuroimaging findings, but histological confirmation remains the diagnostic "gold standard". Molecular markers such as 1p/19q codeletion and isocitrate dehydrogenase (IDH) mutation provide important diagnostic and prognostic information. O-methylguanylmethyltransferase (MGMT) promoter methylation is another favourable prognostic marker and predicts benefit from alkylating agent chemotherapy in glioblastoma. Additionally, the extent of neurosurgical resection is a prognostic factor. Radiother... Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=4881850 Tue, 31 May 2011 19:46:35 +0100 4881850 http://www.medworm.com/index.php?rid=4881849&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21618146%26dopt%3DAbstract Authors: Ferraccioli GF, Gremese E Adiposity is a predisposing condition to atherosclerosis, and rheumatoid arthritis (RA) also predisposes to accelerated atherosclerosis. Adiposity is one of the key features of the metabolic syndrome (MetS) and it is well recognised that a metabolic syndrome (and fat tissue) is a major player in this complex network. Endothelial dysfunction and carotid intima-media thickness, early pre-clinical markers of atherosclerosis which are the main determinants of cardiovascular (CV) morbidity and mortality, occur early on in RA. RA patients have an incidence of CV diseases at least two times higher than the general population. MetS and RA have a low and a severe-moderate degree of inflammation in common, respectively. Adipose tissue has emerged as a dynamic o... Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=4881849 Tue, 31 May 2011 19:46:35 +0100 4881849 http://www.medworm.com/index.php?rid=4881848&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21618147%26dopt%3DAbstract Authors: Zix JA, Schaller B, Lieger O, Saulacic N, Thoren HA, Iizuka T The two major causative factors for mandibular fractures, as stated in the literature, are either interpersonal violence or motor vehicle accidents. The purpose of this study was to describe epidemiological trends of mandibular fractures in Switzerland. A special emphasis was directed towards the potential impact of socio-economic standards on the mechanism and pattern of mandible fractures. PMID: 21618147 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=4881848 Tue, 31 May 2011 19:46:35 +0100 4881848 http://www.medworm.com/index.php?rid=4881847&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21623473%26dopt%3DAbstract CONCLUSIONS: Future efforts need to focus on earlier HCV diagnosis and improvement of treatment uptake among patients in drug substitution programs, particularly if patients are HIV-co-infected. New potent drugs might facilitate the decision to initiate treatment. PMID: 21623473 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=4881847 Tue, 31 May 2011 19:46:35 +0100 4881847 http://www.medworm.com/index.php?rid=4881845&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21623474%26dopt%3DAbstract Authors: Künzli N No summary available. PMID: 21623474 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=4881845 Tue, 31 May 2011 19:46:35 +0100 4881845 http://www.medworm.com/index.php?rid=4881843&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21623475%26dopt%3DAbstract Authors: Stoll D, Dudler J, Lamy O, Hans D, So A, Krieg MA, Aubry-Rozier B Vitamin D is important for bone metabolism and neuromuscular function. While a routine dosage is often proposed in osteoporotic patients, it is not so evident in rheumatology outpatients where it has been shown that the prevalence of hypovitaminosis D is high. The aim of the current study was to systematically evaluate the vitamin D status in our outpatient rheumatology population to define the severity of the problem according to rheumatologic diseases. During November 2009, all patients were offered a screening test for 25-OH vitamin D levels and categorised as deficient (<10 µg/l [ng/ml] [25 nmol/l]), insufficient (10 µg/l to 30 µg/l [25 to 75 nmol/l]) or normal (>30 µg/l [75 nmol/l]). A total of 27... Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=4881843 Tue, 31 May 2011 19:46:35 +0100 4881843 http://www.medworm.com/index.php?rid=4881826&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21623476%26dopt%3DAbstract This study explores adolescents' perceptions of adverse consequences linked to their illegal psychoactive substance (IPS) use, as they are often thought to minimise them. From a Swiss nationally representative sample of 8740 adolescents aged 16 to 20 pursuing post-mandatory education, 2515 participants reported IPS use in the past month on a self-administered anonymous questionnaire. The percentages of participants reporting problems in four areas (individual, school, relationships and sexual) were assessed, depending on the type of IPS consumption over the last 30 days: occasional cannabis users: ≤2 times; regular cannabis users: ≥3 times; and poly-consumers: cannabis plus at least one other substance used. The percentages varied significantly across these three groups with 26.9% of o... Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=4881826 Tue, 31 May 2011 19:46:35 +0100 4881826 http://www.medworm.com/index.php?rid=4881824&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21623477%26dopt%3DAbstract CONCLUSIONS: Compared with the two years preceding the implementation of a smoking ban, the incidence of AMI remained significantly reduced in the second year of the ban in Graubünden, whereas no similar reduction was seen in a comparable area without smoke-free legislation. Changes in outdoor air pollution or the use of lipid-lowering drugs did not substantially contribute to the decrease in the incidence of AMI that occurred after adoption of the ban in Graubünden. PMID: 21623477 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=4881824 Tue, 31 May 2011 19:46:35 +0100 4881824 http://www.medworm.com/index.php?rid=4828769&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21374530%26dopt%3DAbstract Authors: Stöhr S, Bollag Y, Auerbach H, Eichler K, Imhof D, Fabbro T, Gyr N Considerable criticism has lately been raised by the media regarding the quality of Swiss medical expertises. The present investigation was therefore undertaken to assess the professional quality of Swiss medical expertises. The study was part of a market analysis of medical expertises (MGS study). PMID: 21374530 [PubMed - indexed for MEDLINE] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=4828769 Tue, 17 May 2011 12:15:17 +0100 4828769 http://www.medworm.com/index.php?rid=4828768&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21541856%26dopt%3DAbstract Authors: Yildiz M, Tettenborn B, Putzki N Vitamin D levels have not been previously published for Swiss multiple sclerosis (MS) patients. An association between vitamin D status and disease activity in MS has been suggested. PMID: 21541856 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=4828768 Tue, 17 May 2011 12:15:17 +0100 4828768 http://www.medworm.com/index.php?rid=4828767&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21557111%26dopt%3DAbstract Authors: Dudler J, Möller B, Michel BA, Villiger P The new paradigm of therapy in rheumatoid arthritis is to aim toward early and complete remission, using a larger use of conventional DMARDs and biologic agents. The present recommendations were established through a consensus to help practitioners in their daily use of those agents, to reflect the current "best practice" in Switzerland. PMID: 21557111 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=4828767 Tue, 17 May 2011 12:15:17 +0100 4828767 http://www.medworm.com/index.php?rid=4828766&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21557112%26dopt%3DAbstract Authors: Weber A, Boege YT, Reisinger F, Heikenwälder M Inflammatory responses in the liver - a central constituent of hepatic wound healing - can be self-limited or persistent depending on the aetiology, liver health state, concentration of toxins or pathogens, and the time frame of exposure to toxins or infection. In case the immune system eradicates a pathogen or in case toxin-exposure is transient, acute hepatitis resolves and the affected liver tissue regenerates ad integrum. However, in many cases liver damage remains chronic. Irrespective of the aetiology, chronic liver damage drives chronic hepatitis and hepatocyte death as well as compensatory proliferation, reflecting liver regeneration. Over time this potentially promotes further hepatic damage, fibrosis, cirrhosis and live... Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=4828766 Tue, 17 May 2011 12:15:17 +0100 4828766 http://www.medworm.com/index.php?rid=4828765&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21557113%26dopt%3DAbstract Authors: Twerenbold R, Reichlin T, Reiter M, Müller C Cardiac troponin I and T (cTn) are structural proteins unique to the heart. Detection of cTn in peripheral blood indicates cardiomyocyte necrosis. As acute myocardial infarction (AMI) is the most important cause of cardiomyocyte necrosis, cTns have become an integral part in the diagnosis of AMI. In this indication, cTns are superior to all other biomarkers indicating cardiomyocyte necrosis such as CK-MB and myoglobin, and are therefore considered the preferred marker in the diagnosis of AMI. It is important to highlight that cTn indicates and quantifies cardiomyocyte necrosis irrespective of its cause? The major limitation of contemporary cTn assays is a sensitivity deficit in the first few hours of AMI due to a delayed increase o... Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=4828765 Tue, 17 May 2011 12:15:17 +0100 4828765 http://www.medworm.com/index.php?rid=4828756&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21557114%26dopt%3DAbstract Authors: Hang L, Shao D, Sun W Various research programmes have shown that intraoperative infusion of remifentanil has been associated with postoperative hyperalgesia. Previous studies have demonstrated that low-dose ketamine can inhibit central sensitisation and prevent opioid-induced hyperalgesia (OIH). However, the optimal ketamine dose to prevent OIH has not been determined. In the present study we aimed to determine the ED50 and ED95 of ketamine for prevention of postoperative hyperalgesia after remifentanil-based anaesthesia in patients undergoing laparoscopic cholecystectomy. PMID: 21557114 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=4828756 Tue, 17 May 2011 12:15:17 +0100 4828756 http://www.medworm.com/index.php?rid=4828748&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21557115%26dopt%3DAbstract Authors: Chao CT No abstract available. PMID: 21557115 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=4828748 Tue, 17 May 2011 12:15:17 +0100 4828748 http://www.medworm.com/index.php?rid=4828747&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21557116%26dopt%3DAbstract Access and outcome in chronic haemodialysis: which one takes the lead - the first, the last or the one with longest lifespan? - Reply to the letter to the Editor "Chronic haemodialysis: the access determines the outcome?" by Chia-Ter Chao. Swiss Med Wkly. 2011;141:w13188 Authors: Praehauser C, Breidthardt T, Mayr M No abstract available. PMID: 21557116 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=4828747 Tue, 17 May 2011 12:15:17 +0100 4828747 http://www.medworm.com/index.php?rid=4828746&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21574066%26dopt%3DAbstract Authors: Romao S, Münz C Macroautophagy is a main catabolic pathway of eukaryotic cells, delivering cytoplasmic constituents for lysosomal degradation. Originally described as a starvation response, it has now been realised that macroautophagy supports many aspects of innate and adaptive immunity by facilitating innate pathogen detection and antigen presentation, as well as pathogen clearance and lymphocyte expansion. In the first half of this review, we summarise new insights into substrate selection and macroautophagic support of vesicular transport pathways, which underlie macroautophagic regulation of afferent and efferent immunity to pathogens, as outlined in the second half of the review. Applying this increased mechanistic understanding to infectious disease settings should all... Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=4828746 Tue, 17 May 2011 12:15:17 +0100 4828746 http://www.medworm.com/index.php?rid=4828745&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21574067%26dopt%3DAbstract The objective of the study was to assess the prevalence of dyslipidemia in a cohort of patients living in Switzerland and receiving statin therapy. PMID: 21574067 [PubMed - in process] (Source: Swiss Medical Weekly) Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=4828745 Tue, 17 May 2011 12:15:17 +0100 4828745 http://www.medworm.com/index.php?rid=4828744&cid=s_30423_22_f&fid=30423&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21574068%26dopt%3DAbstract Authors: Meisser A, Schelling E, Zinsstag J One Health stands for the health of humans, animals and the environment. There is only one health in our entire ecosystem, and the equation for its promotion is in interdisciplinary cooperation. One Health benefits from synergies to generate added value and is a promising strategy to strengthen health systems. A growing number of One Health conferences worldwide bear witness to a spirit of optimism which should result in the implementation of a sustainable One Health policy globally, regionally, nationally and locally. The purpose of this study was to investigate the opportunities for implementation of the One Health concept in Switzerland. Between April and August 2010, semi-structured face-to-face interviews were conducted with 16 key exper... Swiss Medical Weekly journals http://www.medworm.com/rss/comments.php?id=4828744 Tue, 17 May 2011 12:15:17 +0100 4828744