MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'The American Journal of Chinese Medicine' source. Wed, 08 Feb 2012 10:18:36 +0100 http://www.medworm.com/index.php?rid=5661028&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22298444%26dopt%3DAbstract Authors: Ushiroyama T, Yokoyama N, Hakukawa M, Sakuma K, Ichikawa F, Yoshida S Abstract Despite the recent technological advances in in vitro fertilization and embryo transfer (IVF-ET), a significant proportion of women still do not become pregnant after long-term infertility, whether it is originally due to older age or other undetermined factors. In the present study, macrophage activating Chinese herbs (MACH) were evaluated for their effects on embryo qualities in women who were undergoing repeated IVF-ET because of long-term infertility. Thirty women, who had significantly low rates of developing good quality cleaved embryos and did not become pregnant after three or more cycles of Assisted Reproductive Technology (ART) procedure, were included in the study. Oral administration... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=5661028 Mon, 06 Feb 2012 03:06:02 +0100 5661028 http://www.medworm.com/index.php?rid=5661027&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22298445%26dopt%3DAbstract In conclusion, the TCM compound formula based on SZ + NUH could be a safe and effective option for SDB treatment. PMID: 22298445 [PubMed - in process] (Source: The American Journal of Chinese Medicine) The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=5661027 Mon, 06 Feb 2012 03:06:02 +0100 5661027 http://www.medworm.com/index.php?rid=5661026&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22298446%26dopt%3DAbstract Authors: Wang B, Ni Q, Wang X, Lin L Abstract Ligustrazine, a bioactive component contained in Chuanxiong (Ligusticum chuanxiong Hort), is widely applied in the treatment of vascular diseases in China, e.g. myocardial and cerebral infarction. The aim of this study was to perform a meta-analysis of randomized controlled trials (RCTs) to evaluate the clinical effect of Ligustrazine on diabetic nephropathy (DN). PUBMED, EMBASE, the Cochrane Central Register of Controlled Trials (CENTRAL), Chinese Biological Medicine Database (CBM), China National Knowledge Infrastructure (CNKI) Database, etc. were searched by computer and manual methods to identify RCTs that were used to evaluate the clinical effect of Ligustrazine on DN patients. Twenty five studies comprising 25 RCTs were involved i... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=5661026 Mon, 06 Feb 2012 03:06:02 +0100 5661026 http://www.medworm.com/index.php?rid=5661025&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22298447%26dopt%3DAbstract Authors: Lo SY Abstract A twelve-week pilot study was conducted on 11 male children, aged five to 19 years, who had ASD (autistic symptom disorder) of varying degrees of severity. These eleven subjects were each examined three times in the 12-week period: at the first week, 6th week, and 12th week. During each examination, two sets of full-body thermographs were taken of each child, before and fifteen minutes after drinking a solution of stable water clusters with a double helix configuration. This solution of stable water clusters is called double helix water (DHW). In the before thermographs, a consistent thermal pattern of six hot regions of body surface temperature were identified. They are: left and right upper forehead region of the face; left and right area in front of the c... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=5661025 Mon, 06 Feb 2012 03:06:02 +0100 5661025 http://www.medworm.com/index.php?rid=5661015&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22298448%26dopt%3DAbstract This study provides evidence of possible herb-drug interactions involved with certain single herbs. PMID: 22298448 [PubMed - in process] (Source: The American Journal of Chinese Medicine) The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=5661015 Mon, 06 Feb 2012 03:06:02 +0100 5661015 http://www.medworm.com/index.php?rid=5661014&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22298449%26dopt%3DAbstract Authors: Chou WC, Liu HJ, Lin YW, Cheng CY, Li TC, Tang NY, Hsieh CL Abstract According to the principles of traditional Chinese medicine, channels and collaterals within the body provide pathways through which qi and blood travel, and each channel or collateral is linked with a specific organ. The Yinlingquan (spleen 9, SP9) and Ququan (liver 8, LR8) acupoints represent the sea points of the spleen and liver meridians, respectively, from which qi and blood flow into their specific visceral organs. The purpose of this study was to investigate the changes in blood flow/perfusion in the liver and spleen resulting from the application of 2 Hz electro-acupuncture (EA) to the Yinlingquan (SP9) or Ququan (LR8) acupoints. A total of 18 Spragrue-Dawley rats were randomly divided into three... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=5661014 Mon, 06 Feb 2012 03:06:02 +0100 5661014 http://www.medworm.com/index.php?rid=5661013&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22298450%26dopt%3DAbstract Authors: Shin JW, Kang HC, Shim J, Sohn NW Abstract Disruption of the blood-brain barrier (BBB) contributes to the inflammatory response and edema formation in the brain, exacerbating brain damage. The present study evaluated the effects of Scutellaria baicalensis (SR) water extracts on BBB disruption after intracerebral hemorrhage (ICH) in rats. ICH was induced by stereotaxic intrastriatal injection of bacterial type VII collagenase, and SR was administrated orally three times (50 mg/ml/kg) during the 48 h after ICH onset. SR treatment significantly reduced the degree of (1) hemorrhage volume and edema percentage of the ipsilateral hemisphere, (2) brain water content, (3) MPO-positive neutrophil infiltration in the peri-hematoma, and (4) BBB permeability measured by Evans blue lea... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=5661013 Mon, 06 Feb 2012 03:06:02 +0100 5661013 http://www.medworm.com/index.php?rid=5661012&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22298451%26dopt%3DAbstract Authors: Roman-Ramos R, Almanza-Perez JC, Fortis-Barrera A, Angeles-Mejia S, Banderas-Dorantes TR, Zamilpa-Alvarez A, Diaz-Flores M, Jasso I, Blancas-Flores G, Gomez J, Alarcon-Aguilar FJ Abstract Type 2 diabetes is characterized by oxidative stress and a chronic low-grade inflammatory state, which also play roles in the pathogenesis of this disease and the accompanying vascular complications by increasing the production of free radicals and pro-inflammatory cytokines. Cucurbita ficifolia Bouché (C. ficifolia) is an edible Mexican plant whose hypoglycemic activity has been demonstrated in several experimental and clinical conditions. Recently, D-chiro-inositol has been proposed as the compound responsible for the hypoglycemic effects; however, the antioxidant and anti-inflammatory... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=5661012 Mon, 06 Feb 2012 03:06:02 +0100 5661012 http://www.medworm.com/index.php?rid=5661011&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22298452%26dopt%3DAbstract Authors: Kim NH, Moon PD, Pak SC, Kim HM, Jeong HJ Abstract The purpose of the present study was to investigate the anti-fatigue effect of Zizania caudiflora (Turczaninow) Nakai (ZC) and hydrolyzed ZC by malted barley (HZC) through a forced swimming test (FST) in mice. After the first measurement of immobility times, the mice were divided into control, fluoxetine, ZC, and HZC groups to match the swimming times in each group. The immobility times in the FST of the control as well as the fluoxetine, ZC, and HZC-administered groups after administration for three days were 135.3 ± 3.3,66.8 ± 3.9,120.2 ± 2.7, and 123.2 ± 2.9 sec, respectively. The immobility times in the FST of the ZC and HZC-administered groups for 14 days were significantly decreased in comparison with the control... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=5661011 Mon, 06 Feb 2012 03:06:02 +0100 5661011 http://www.medworm.com/index.php?rid=5661010&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22298453%26dopt%3DAbstract Authors: Yao L, Dong W, Lu F, Liu S Abstract Rhizoma Dioscoreae Nipponicae (RDN) is an herbal medicine. In the theories of Traditional Chinese Medicine (TCM), the function of RDN is to expel wind and remove dampness. Inflammatory mechanisms play an important role in the pathological process and prognosis of acute gouty arthritis (AGA). The aim of this study was to determine the specially expressed proteins through testing the proteins of the synovium in rats with AGA. The animal model of AGA was set up by Monosodium urate crystal (MSU) combined with hypoxanthine (HX), which was ameliorated in our previous experiment. Blood samples for measurement of serum uric acid were collected prior to sacrifice. Outcomes were assessed (two days after injection) by histological stain and protein... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=5661010 Mon, 06 Feb 2012 03:06:02 +0100 5661010 http://www.medworm.com/index.php?rid=5661009&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22298454%26dopt%3DAbstract This study attempts to determine the effects of EC on lipopolysaccharide (LPS)-induced inflammatory responses in mouse peritoneal macrophages. The findings of the study show that EC inhibits the LPS-induced production of tumor necrosis factor-alpha and interleukin-6. Exposure to EC also reduces an inflammation-induced increase in the levels of cyclooxigenase-2 and the production of prostaglandin E(2) and nitric oxide in mouse peritoneal macrophages. Furthermore, EC suppresses the activation of nuclear factor-kappa B and caspase-1. These results provide novel insights into the pharmacological action of EC and indicate that EC has a potential in the treatment of inflammatory diseases. PMID: 22298454 [PubMed - in process] (Source: The American Journal of Chinese Medicine) The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=5661009 Mon, 06 Feb 2012 03:06:02 +0100 5661009 http://www.medworm.com/index.php?rid=5661008&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22298455%26dopt%3DAbstract Authors: Wang KC, Chang JS, Chiang LC, Lin CC Abstract Human respiratory syncytial virus (HRSV) causes serious pediatric infection of the lower respiratory tract without effective therapeutic modality. Sheng-Ma-Ge-Gen-Tang (SMGGT; Shoma-kakkon-to) has been proven to be effective at inhibiting HRSV-induced plaque formation, and Cimicifuga foetida is the major constituent of SMGGT. We tested the hypothesis that C. foetida effectively inhibited the cytopathic effects of HRSV by a plaque reduction assay in both human upper (HEp2) and lower (A549) respiratory tract cell lines. Its ability to stimulate anti-viral cytokines was evaluated by an enzyme-linked immunosorbent assay (ELISA). C. foetida dose-dependently inhibited HRSV-induced plaque formation (p < 0.0001) before and after vir... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=5661008 Mon, 06 Feb 2012 03:06:02 +0100 5661008 http://www.medworm.com/index.php?rid=5661007&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22298456%26dopt%3DAbstract Authors: Naowaboot J, Pannangpetch P, Kukongviriyapan V, Prawan A, Kukongviriyapan U, Itharat A Abstract Mulberry (Morus alba L.) leaf tea is promoted for its health benefits and the control of diabetes in Asian nations. The blood glucose lowering activity of mulberry leaf extract (MA) has been proven; however, the molecular basis underlying this effect remains unclear. The aim of the present work is to elucidate its mechanism of the antihyperglycemic action, by examining the effect of MA on glucose uptake and the translocation of glucose transporter 4 protein (GLUT4) to the plasma membrane of adipocytes isolated from diabetic rats. The incubation of adipocytes with 5-45 μg/ml MA resulted in 31-54% increase of glucose uptake in a dose-dependent manner. This glucose uptake enhancin... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=5661007 Mon, 06 Feb 2012 03:06:02 +0100 5661007 http://www.medworm.com/index.php?rid=5661006&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22298457%26dopt%3DAbstract In this study, its anti-tumor potential was investigated with breast cancer line cells MCF-7 in vitro. The anti-proliferative effect of dehydrocorydaline was determined by MTT assay and the mitochondrial membrane potential (Δ Ψ m) was monitored by JC-1 staining. DNA fragments were visualized by Hoechst 33342 staining and DNA ladder assay. Apoptotic related protein expressions were measured by Western blotting. Dehydrocorydaline significantly inhibited MCF-7 cell proliferation in a dose- dependent manner, which could be reversed by a caspase-8 inhibitor, Z-IETD-FMK. Dehydrocorydaline increased DNA fragments without affecting ΔΨm. Western blotting assay showed that dehydrocorydaline dose-dependently increased Bax protein expression and decreased Bcl-2 protein expression. Furthermore, deh... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=5661006 Mon, 06 Feb 2012 03:06:02 +0100 5661006 http://www.medworm.com/index.php?rid=5661005&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22298458%26dopt%3DAbstract Authors: Hwang JW, Oh JH, Yoo HS, Lee YW, Cho CK, Kwon KR, Yoon JH, Park J, Her S, Lee ZW, Jang IS, Choi JS Abstract Administration of mountain ginseng (MG) extract can restore advanced cancer to a normal state. To elucidate the mechanism by which MG extract prevents the progression of lung cancer, the processes of proliferation and death of lung cancer cells (A549) were examined after treatment with MG extract. Butanol-extracted MG (BX-MG) showed a high inhibitory effect (IC(50) = 2 mg/ml) by attenuating proliferation and inducing apoptosis in lung cancer cells. By HPLC-UV analysis of BX-MG, ginsenosides, Rb1 was identified as the most abundant ginsenoside, followed by Rg1, Re, Rc and Rb2. BX-MG induced caspase-3 dependent apoptosis by inhibiting NF-κB. In addition, BX-MG activat... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=5661005 Mon, 06 Feb 2012 03:06:02 +0100 5661005 http://www.medworm.com/index.php?rid=5661004&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22298459%26dopt%3DAbstract Authors: Nagappan A, Karunanithi N, Sentrayaperumal S, Park KI, Park HS, Lee do H, Kang SR, Kim JA, Senthil K, Natesan S, Muthurajan R, Kim GS Abstract Ginsenosides and withanolides are the secondary metabolites from Panax ginseng and Withania somnifera, respectively. These compounds have similar biological properties. Two-dimensional electrophoresis (2-DE) analysis was utilized to reveal the protein profile in the roots of both plants, with the aim of clarifying similarly- and differentially-expressed proteins. Total proteins of Korea ginseng (P. ginseng) and Indian ginseng (W. somnifera) roots were separated by 2-DE using a pH 4-7 immobilized pH gradient strip in the first dimension and 12% sodium dodecyl sulfate polyacrylamide gel electrophoresis in the second dimension. The pro... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=5661004 Mon, 06 Feb 2012 03:06:02 +0100 5661004 http://www.medworm.com/index.php?rid=5424484&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22083994%26dopt%3DAbstract In this study, we have investigated the hypo-pigmentary mechanism of royal jelly in a mouse melanocyte cell line, B16F1. Treatment of B16F1 cells with royal jelly markedly inhibited melanin biosynthesis in a dose-dependent manner. Decreased melanin content occurred through the decrease of tyrosinase activity. The mRNA levels of tyrosinase were also reduced by royal jelly. These results suggest that royal jelly reduces melanin synthesis by down-regulation of tyrosinase mRNA transcription and serves as a new candidate in the design of new skin-whitening or therapeutic agents. PMID: 22083994 [PubMed - in process] (Source: The American Journal of Chinese Medicine) The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=5424484 Sat, 19 Nov 2011 19:54:02 +0100 5424484 http://www.medworm.com/index.php?rid=5282771&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21476208%26dopt%3DAbstract Authors: Koh PO Abstract EGb 761 is a standardized extract of Ginkgo biloba that appears to have a neuroprotective effect against neurodegenerative diseases. Adult male rats were treated with EGb 761 (100 mg/kg) or vehicle prior to middle cerebral artery occlusion (MCAO), and brains were collected 24 h after MCAO. Proteins that were differentially expressed after EGb 761 treatment during cerebral ischemia were detected using two-dimensional gel electrophoresis. Protein spots with more than a 2.5-fold change in intensity between vehicle- and EGb 761-treated groups were identified by mass spectrometry. The levels of peroxiredoxin-2 and protein phosphatase 2A subunit B were significantly decreased in the vehicle-treated group in comparison to the EGb 761-treated group. In contrast, le... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=5282771 Wed, 05 Oct 2011 00:35:02 +0100 5282771 http://www.medworm.com/index.php?rid=5282770&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21476214%26dopt%3DAbstract Authors: Liu X, Wang Y, Ma C, Zhang L, Wu W, Guan S, Yang M, Wang J, Jiang B, Guo DA Abstract Although doxorubicin (DXR) is an important antineoplastic agent, the serious toxicity mediated by the production of reactive oxygen species has remained a considerable clinical problem. Our hypothesis is that tanshinone II A sodium sulfonate (TSNIIA-SS), which holds significant effects against oxidative stress, protects against DXR-induced nephropathy. Firstly, the antioxidative effects of TSNIIA-SS were confirmed using oxygen radicals absorbance capacities (ORAC) assay in vitro. Then, DXR nephropathy was induced by repeated DXR treatment and verified by kidney index (20.76 ± 3.04 mg/mm versus 14.76 ± 3.04 mg/mm, p < 0.001) and histochemical stain. The mice were randomized into three ... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=5282770 Wed, 05 Oct 2011 00:35:02 +0100 5282770 http://www.medworm.com/index.php?rid=5220371&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21905276%26dopt%3DAbstract Authors: Lin CH, Lee LS, Su LH, Huang TC, Liu CF Abstract The aim of this study is to evaluate the effects of far-infrared (FIR) rays on the meridian in hemodialysis (HD) patients. End-stage renal disease or kidney failure is the last stage of chronic renal failure, and often implies that the renal function cannot be restored and HD or kidney transplantation is required as a life-saving measure. HD patients often feel sick, debilitated, demotivated, and sad. A quasi-experimental design was conducted using convenience sampling with 61 HD patients from a hemodialysis center. Meridian testing and Brief Fatigue Inventory-Taiwan Form (BFI-T) were used as screening test for HD. The experimental group (n = 36) received FIR irradiation on each acupoint for 30 min, thrice a week, for two mo... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=5220371 Thu, 15 Sep 2011 14:40:02 +0100 5220371 http://www.medworm.com/index.php?rid=5220370&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21905277%26dopt%3DAbstract This study aimed to explore whether the protective effect of anisodamine is mediated by inhibition of the endoplasmic reticulum stress (ERS) response, which has been demonstrated to implicate in various I/R injuries. After 5 min of CA induced by electric stimulation, Wistar rats were randomly selected to receive cardiopulmonary resuscitation (CPR, including chest compression and epinephrine infusion) with or without anisodamine injection (n = 50/group). Hearts were harvested 24 h after the return of spontaneous circulation (ROSC). Sham-operated animals served as non-ischemic controls (n = 10). The survival rate, cardiomyocyte apoptosis, and the protein expression of ERS markers were detected. Thirty-three of the 50 rats in the Ani + CA/R group were successfully resuscitated, whereas only 1... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=5220370 Thu, 15 Sep 2011 14:40:02 +0100 5220370 http://www.medworm.com/index.php?rid=5220369&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21905278%26dopt%3DAbstract This study investigated the vasodilatory effects and possible mechanisms of Cinnamomi ramulus ethanol extract (CRE), with the hypothesis that the CRE vasodilatory effect involves RhoA and the ROCK signaling pathway in rat aortic preparations. CRE (0.05-1 mg/ml) dose-dependently relaxed the vascular contraction induced by phenylephrine and calpeptin in an endothelium-independent manner. Measurement of the expression levels of ROCK-related signaling molecules in response to calpeptin revealed that CRE completely inhibited RhoA and ROCK2 protein expressions. Furthermore, CRE dephosphorylated the subsequent downstream targets myosin phosphatase targeting subunit 1 (MYPT-1), protein kinase C potentiated phosphatase inhibitor protein-17 kDa (CPI-17) and myosin light chain 20 kDa (MLC20). We conc... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=5220369 Thu, 15 Sep 2011 14:40:02 +0100 5220369 http://www.medworm.com/index.php?rid=5220368&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21905279%26dopt%3DAbstract Authors: Chen R, Shao H, Lin S, Zhang JJ, Xu KQ Abstract Astragalus membranaceus, also known as huang qi, a traditional Chinese medicine, is often used in formulas for deficiency of vital energy characterized by limb weakness, pale face, and dizziness. Previous studies have shown that Astragalus membranaceus could attenuate intestinal ischemia-reperfusion injury induced by hemorrhagic shock in rats; however, the underlying mechanism still remains unclear. Using a hemorrhagic shock rat model to examine the effect of Astragalus membranaceus on intestinal mucosa injury induced by ischemia-reperfusion, we found that treatment (20 g crude drugs/kg, i.v.) produced antioxidative effects in the intestinal mucosa of rats after ischemia-reperfusion (p < 0.05). We also found that Astragalu... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=5220368 Thu, 15 Sep 2011 14:40:02 +0100 5220368 http://www.medworm.com/index.php?rid=5220367&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21905280%26dopt%3DAbstract Authors: Shin S, Lee YJ, Kim EJ, Lee AS, Kang DG, Lee HS Abstract The kidneys play a central role in regulating water, ion composition and excretion of metabolic waste products in the urine. Cuscuta chinensis has been known as an important traditional Oriental medicine for the treatment of liver and kidney disorders. Thus, we studied whether an aqueous extract of Cuscuta chinensis (ACC) seeds has an effect on renal function parameters in ischemia/reperfusion-induced acute renal failure (ARF) rats. Administration of 250 mg/kg/day ACC showed that renal functional parameters including urinary excretion rate, osmolality, Na(+), K(+), Cl(-), creatinine clearance, solute-free water reabsorption were significantly recovered in ischemia/reperfusion-induced ARF. Periodic acid Schiff stainin... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=5220367 Thu, 15 Sep 2011 14:40:02 +0100 5220367 http://www.medworm.com/index.php?rid=5220366&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21905281%26dopt%3DAbstract Authors: Oluwole Busayo A, Laura Z, Olufunke Olubusola D, Oluwafunmike Sharon A, Luciana D, Ezekiel Ademola CM Abstract We studied the effect of ethanolic leaf extract of Azadirachta indica (AIE) on the microanatomy of the kidney of streptozotocin-induced diabetic rats. Thirty male Wistar rats (161-190 g) were randomly assigned to one of five treatment groups of six animals each: control, diabetic, diabetic + AIE, diabetic + metformin, AIE only. Diabetes was induced with a single intraperitoneal dose of streptozotocin (70 mg/kg body weight). AIE and metformin were administered orally for 50 days (50 d) at 500 mg/kg bw/d and 350 mg/kg bw/d, respectively. Blood glucose was estimated by glucose oxidase method; plasma urea and creatinine were assayed; and paraffin sections of the kidne... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=5220366 Thu, 15 Sep 2011 14:40:02 +0100 5220366 http://www.medworm.com/index.php?rid=5220365&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21905282%26dopt%3DAbstract Authors: Jeon S, Hur J, Jeong HJ, Koo BS, Pak SC Abstract SuHeXiang Wan (SHXW), a traditional Chinese medicine, has been used orally for the treatment of seizures, infantile convulsions and stroke. Previously, we reported the effects of a modified SHXW essential oil in terms of sedative effect, anticonvulsant activity and antioxidative activity. The purpose of this study was to evaluate the potential beneficial effects of SHXW essential oil in neurodegenerative diseases such as Alzheimer's disease (AD). SHXW essential oil was extracted from nine herbs. The mouse AD model was induced by a single injection of amyloid β protein (Aβ(1-42)) into the hippocampus. The animals were divided into four groups, the negative control group injected with Aβ(42-1), the Aβ group injected with A... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=5220365 Thu, 15 Sep 2011 14:40:02 +0100 5220365 http://www.medworm.com/index.php?rid=5220364&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21905283%26dopt%3DAbstract This study demonstrates that administration of MAT, as a natural compound, might be a novel therapy for autoimmune disorders such as MS. PMID: 21905283 [PubMed - in process] (Source: The American Journal of Chinese Medicine) The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=5220364 Thu, 15 Sep 2011 14:40:02 +0100 5220364 http://www.medworm.com/index.php?rid=5220363&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21905284%26dopt%3DAbstract Authors: Tsai JC, Peng WH, Chiu TH, Lai SC, Lee CY Abstract The aims of this study intended to investigate the anti-inflammatory activity of the 70% ethanol extract from Scoparia dulcis (SDE) and betulinic acid on λ-carrageenan-induced paw edema in mice. The anti-inflammatory mechanism of SDE and betulinic acid was examined by detecting the levels of cyclooxygenase-2 (COX-2), nitric oxide (NO), tumor necrosis factor (TNF-α), interleukin-1β (IL-1β) and malondialdehyde (MDA) in the edema paw tissue and the activities of superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione reductase (GRd) in the liver. The betulinic acid content in SDE was detected by high performance liquid chromatography (HPLC). In the anti-inflammatory model, the results showed that SDE (0.5... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=5220363 Thu, 15 Sep 2011 14:40:02 +0100 5220363 http://www.medworm.com/index.php?rid=5220362&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21905285%26dopt%3DAbstract This study investigated the protective effect of OD in dextran sulfate sodium (DSS)-induced colitis. Mice treated with DSS showed remarkable clinical signs, including weight loss, and reduced colon length. Administration of OD attenuated these signs and significantly suppressed levels of interleukin (IL)-6, IL-1β and expression of cyclooxygenase-2 in DSS-treated colon tissues. OD also reduced the activation of transcription nuclear factor-κB p65 in DSS-treated colon tissues. Hentriacontane, a constituent of OD, attenuated weight loss, colon shortening, and levels of IL-6 caused by DSS. Taken together, the results provide experimental evidence that OD might be a useful therapeutic medicine for patients with UC. PMID: 21905285 [PubMed - in process] (Source: The American Journal of Chin... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=5220362 Thu, 15 Sep 2011 14:40:02 +0100 5220362 http://www.medworm.com/index.php?rid=5220361&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21905286%26dopt%3DAbstract In this study, we investigated whether EGb 761 regulates the expression of PEA-15 and two phosphorylated forms of PEA-15 (Ser 104 and Ser 116) in middle cerebral artery occlusion (MCAO)-induced injury. Adult male rats were treated with vehicle or EGb 761 (100 mg/kg) prior to MCAO and cerebral cortices were collected 24 h after MCAO. A reduction in expression of PEA-15 and its phosphorylated forms induced by MCAO injury was detected using a proteomic approach. EGb 761 pretreatment prevented the ischemic injury-induced decrease in PEA-15 expression. Western blot analysis demonstrated that EGb 761 attenuates the injury-induced reduction in PEA-15, phospho-PEA-15 (Ser 104), phospho-PEA-15 (Ser 116). Phosphorylation of PEA-15 influences its anti-apoptotic function; a decrease in PEA-15 phosphor... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=5220361 Thu, 15 Sep 2011 14:40:02 +0100 5220361 http://www.medworm.com/index.php?rid=5220360&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21905287%26dopt%3DAbstract In conclusion, these findings provide scientific evidence that the processed RA indeed possesses not only enhanced neuropharmacological efficacy but also reduced neurotoxic effects as compared to the unprocessed crude RA. The signaling of NO(x)/oxidative stress/Na(+)-K(+)- ATPase activities played a role, at least in part, in the underlying mechanisms of neurotoxic effects induced by the crude RA. PMID: 21905287 [PubMed - in process] (Source: The American Journal of Chinese Medicine) The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=5220360 Thu, 15 Sep 2011 14:40:02 +0100 5220360 http://www.medworm.com/index.php?rid=5220359&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21905288%26dopt%3DAbstract Authors: Si YC, Zhang JP, Xie CE, Zhang LJ, Jiang XN Abstract We aimed to investigate the effects of Panax notoginseng saponins (PNS) on proliferation, differentiation and self-renewal of rat hippocampal neural stem cells (NSCs) in vitro. Rat hippocampal NSCs were isolated from post-natal day 1 (P1) rats and cultured in a serum-free medium. The neurospheres were identified by the expressions of nestin, class III β-tublin (Tuj-1) and glial fibrillary acid protein (GFAP). The cells were given PNS and subjected to oxygen glucose deprivation (OGD) as an in vitro model of brain ischemia reperfusion. The proliferation of NSCs was determined by MTT colorimetry, nestin/BrdU immunofluorescent double-labeling and RT-PCR. Differentiation of NSCs was assessed by immunofluorescent double-label... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=5220359 Thu, 15 Sep 2011 14:40:02 +0100 5220359 http://www.medworm.com/index.php?rid=5220358&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21905289%26dopt%3DAbstract Authors: Kim HK, Baek SS, Cho HY Abstract Intestinal glucose uptake is mainly performed by its specific transporters, SGLT1 and GLUTs expressed in the intestinal epithelial cells. By using Caco-2 cells and 2-NBDG, we observed that intestinal glucose uptake was markedly inhibited by pomegranate (Punica granatum L, PG) among 200 screened edible Korean plants. The effects of the PG extract on Na(+)-dependent glucose uptake were further evaluated using brush border membrane vesicles (BBMV) obtained from the mouse small intestine. PG inhibited Na(+)-dependent glucose uptake with the IC(50) value of 424 μg/ml. The SGLT1 protein expression was dose dependently down regulated with PG treatment in Caco-2 cells. We next assessed the antihyperglycemic effect of PG in streptozotocin (STZ)-ind... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=5220358 Thu, 15 Sep 2011 14:40:02 +0100 5220358 http://www.medworm.com/index.php?rid=5220357&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21905290%26dopt%3DAbstract Authors: Chen CY, Chen JX, Li W, Li H, Yang B Abstract Radix Scutellariae has been widely used to hasten the process of heat clearing and dampness drying in traditional Chinese medicine. The resource of wild Radix Scutellariae is scarce; an increasing amount of cultivated Radix Scutellariae has become available in the market. To determine the clinical effects of Radix Scutellariae, we conducted a comparative analysis of the chemical compositions of cultivated and wild Radix Scutellariae. An HPLC fingerprint method was developed to determine simultaneously the amounts of baicalin, baicalein, and wogonin, which have been identified as active compounds in Radix Scutellariae. Chinese pharmacopoeia methodology was also applied to measure the ethanolic extract content of the wild and cul... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=5220357 Thu, 15 Sep 2011 14:40:02 +0100 5220357 http://www.medworm.com/index.php?rid=5220356&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21905291%26dopt%3DAbstract This study developed a RP-HPLC-UV method for the simultaneous determination of eight amides and two lignans in twelve different species of Piper. HPLC separation was accomplished on a C18 analytical column (5 μm, 250 mm × 4.6 mm, i.d.) with a gradient mobile phase consisting of acetonitrile and water at a flow rate of 1.0 ml/min. All the calibration curves showed good linear correlation coefficients (r > 0.9997) over the test ranges. The relative standard deviation of the current method was less than 2.90% for intra- and inter-day assays and the average recoveries were between 98.25% and 103.08%. The HPLC method established is appropriate for quality control purposes and allows for the differentiation of Piper species. PMID: 21905291 [PubMed - in process] (Source: The American Jou... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=5220356 Thu, 15 Sep 2011 14:40:02 +0100 5220356 http://www.medworm.com/index.php?rid=5062894&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21721145%26dopt%3DAbstract In this study, we compared articles from these three regions published in international CAM journals from 2000 to 2009 using PubMed database and the Journal Citation Reports. The study results showed that the number of published articles from Mainland China increased significantly from 2000 to 2009, particularly since 2005. Meanwhile, the number of published articles from Taiwan also increased, whereas those from Hong Kong remained steady. Clinical trials and randomized controlled trials from Chinese authors both took a small percentage of the total. The impact factors of the journals in which these articles were published suggested similar academic levels whereas the average number of citation of articles from the Mainland was less than those from the other two regions. Journal of Ethnoph... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=5062894 Tue, 26 Jul 2011 11:00:02 +0100 5062894 http://www.medworm.com/index.php?rid=5062893&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21721146%26dopt%3DAbstract Authors: Wang J, Li Y, Ni C, Zhang H, Li L, Wang Q In the Western medicine system, scholars have explained individual differences in terms of behaviour and thinking, leading to the emergence of various classification theories on individual differences. Traditional Chinese medicine has long observed human constitutions. Modern Chinese medicine studies have also involved study of human constitutions; however, differences exist in the ways traditional and modern Chinese medicine explore individual constitutions. In the late 1970s, the constitutional theory of Chinese medicine was proposed. This theory takes a global and dynamic view of human differences (e.g., the shape of the human body, function, psychology, and other characteristics) based on arguments from traditional Chinese medicine... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=5062893 Tue, 26 Jul 2011 11:00:02 +0100 5062893 http://www.medworm.com/index.php?rid=5062892&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21721147%26dopt%3DAbstract Authors: Wang CZ, Mehendale SR, Calway T, Yuan CS Ischemic heart disease (IHD) is one of the leading causes of death in Western countries. Prevention rather than treatment of heart disease can significantly improve patients' quality of life and reduce health care costs. Flavonoids are widely distributed in vegetables, fruits and herbal medicines. Regularly consuming botanicals, especially those containing flavonoids, has been associated with a reduction in cardiovascualar disease; thus, it is important to investigate how flavonoids improve cardiac resistance to heart disease and their related mechanisms of action. It has been shown that cardiomyocyte injury and death can result from ischemia-reperfusion, which is pathognomonic of ischemic heart disease. Massive reactive oxygen species ... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=5062892 Tue, 26 Jul 2011 11:00:02 +0100 5062892 http://www.medworm.com/index.php?rid=5062891&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21721148%26dopt%3DAbstract In this study, 24 subjects without heart or neural diseases were randomly separated into two groups of 12, named test and control groups. Similar procedures are performed; the subjects lay on a bed with eyes closed for ten minutes as the baseline. The test group received acupuncture at their Waiguan points (TE5) on their left hands for 20 minutes, while the control group did not. EEGs are recorded during pre-acupuncture, acupuncture stimulation and post-acupuncture stimulation periods. The EEG electrodes are at the T3, T4, O1 and O2 locations. Continuous wavelet transformation analysis is adopted; therefore, EEGs are divided into the following bands: δ (0.5-4HZ), θ (4-8HZ), α (8-13HZ) and β (13-30HZ). During acupuncture stimulation, the θ energy is increased and had statistical differ... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=5062891 Tue, 26 Jul 2011 11:00:02 +0100 5062891 http://www.medworm.com/index.php?rid=5062890&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21721149%26dopt%3DAbstract Authors: Li CR, Cheng ZD, Zhang ZX, Kim A, Ha JM, Song YY, Zheng J, Chen YG This research explored and identified the protein composition of rat kidneys after acupuncture at the Taixi acupoint (KI3). Twelve adult male Wistar rats were randomly divided into a control group (n = 6) and an acupuncture group (n = 6). Rats in the acupuncture group received electroacupuncture on the bilateral KI3 for seven days. The kidneys were perfused with ice-cold saline and all kidney proteins were isolated. After protein sample preparation, two-dimensional gel electrophoresis (2-DE) was performed. The interesting spots were analyzed using matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS). There were nine protein spots with three-fold up-regulation in the kidney... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=5062890 Tue, 26 Jul 2011 11:00:02 +0100 5062890 http://www.medworm.com/index.php?rid=5062889&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21721150%26dopt%3DAbstract In this study, extract of the dry root of Scutellaria baicalensis Georgi (Sb) was confirmed to have a high content of flavonoids and phenolic compounds. The cardioprotective effects of the Sb extracts (3, 30 and 300 mg/kg) were evaluated in myocardial ischemia-reperfusion injuried rats. The results showed that animals that had received five-day pretreatment of the Sb extract (30 mg/kg) had a significant reduction in myocardial infarct size and a marked increase in the activity of catalase in the liver. The Sb extract could additionally enhance acetylcholine-induced vasorelaxation. It was proposed that the Sb extract exerted its cardioprotection by stimulating the catalase activity and improving vascular elasticity. PMID: 21721150 [PubMed - in process] (Source: The American Journal of C... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=5062889 Tue, 26 Jul 2011 11:00:02 +0100 5062889 http://www.medworm.com/index.php?rid=5062888&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21721151%26dopt%3DAbstract Authors: Hung HF, Hou CW, Chen YL, Lin CC, Fu HW, Wang JS, Jeng KC Elephantopus scaber (ES, Teng-Khia-U) has been traditionally used for the treatment of nephritis, pain, and fever; however, the direct evidence is lacking. We investigated the effect of ES on lipopolysaccharide (LPS) induced inflammation of BV-2 microglial cells and acute liver injury in Sprague-Dawley (SD) rats. Our results showed that ES reduced LPS-induced nitric oxide (NO), interleukin (IL)-1, IL-6, reactive oxygen species (ROS), and prostaglandin (PGE(2)) production in BV-2 cells. ES significantly decreased serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels in LPS-treated rats. Furthermore, the water extract, but not the ethanol extract, of ES dose-dependently inhibited LPS-induced JNK... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=5062888 Tue, 26 Jul 2011 11:00:02 +0100 5062888 http://www.medworm.com/index.php?rid=5062887&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21721152%26dopt%3DAbstract In this study, we compared the medicinal effects of A. cochinchinensis root and stem extracts on the activity of superoxide dismutase (SOD), the content of malonaldehyde (MDA) and total protein content in the brain, liver and plasma of mice. Polysaccharides and aqueous extracts of the roots significantly increased the spleen index and the SOD activity but reduced the MDA content and slowed down the aging process. In contrast, feeding with the stem extracts significantly reduced the SOD activity and increased the MDA accumulation in the brain and liver of mice, suggesting that the stem extracts may not be appropriate for treating aging-related diseases. PMID: 21721152 [PubMed - in process] (Source: The American Journal of Chinese Medicine) The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=5062887 Tue, 26 Jul 2011 11:00:02 +0100 5062887 http://www.medworm.com/index.php?rid=5062886&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21721153%26dopt%3DAbstract Authors: Johnson TE, Hermanson D, Wang L, Kassie F, Upadhyaya P, O'Sullivan MG, Hecht SS, Lu J, Xing C Lung cancer is the most deadly malignancy in the US. Chemoprevention is potentially a complementary approach to smoking cessation for lung cancer control. Recently, we reported that a commercially available form of kava extract significantly inhibits 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and benzo(a)pyrene (BaP)-induced lung tumorigenesis in A/J mice at a dose of 10 mg per gram diet. In the present study, we examined the dose-dependent lung tumor inhibitory activities of kava and investigated potential active constituent(s). Mice treated with carcinogen alone contained 12.1±5.8 lung adenomas per mouse 22 weeks after final carcinogen administration. Mice that were fed d... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=5062886 Tue, 26 Jul 2011 11:00:02 +0100 5062886 http://www.medworm.com/index.php?rid=5062885&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21721154%26dopt%3DAbstract We reported that TJ-48, a common Japanese herbal medicine, decreased Treg population in cancer patients, thus we investigated whether TJ-48 had an influence on T1DM onset using NOD mice. In the TJ-48 group, TJ-48 (2.0g/kg/day) was administered in the drinking water for NOD mice from three weeks of age to 20 weeks of age. Their body weight and fast blood glucose (FBG) were measured every week. Histology (Hematoxylin-Eosin staining) was investigated every month. Lymphocyte profiles were investigated every month with FACS. The results were compared to the age-matched NOD mice control group. FBG of the control group mice showed diabetic status of 66.7% at 18 weeks of age. On the other hand, the TJ-48 group mice showed diabetic status of 16.7% at 18 weeks of age (p = 1.905E-06). There were no s... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=5062885 Tue, 26 Jul 2011 11:00:02 +0100 5062885 http://www.medworm.com/index.php?rid=5062884&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21721155%26dopt%3DAbstract Authors: Katoh A, Fukuda S, Fukusaki E, Hashimoto T, Hayasaki T, Kanaya S, Komura H, Nomoto K, Shojo M, Takeno KJ The commercial quality of Japanese Angelica radices - Angelica acutiloba Kitagawa (Yamato-toki) and A. acutiloba Kitagawa var. sugiyama Hikino (Hokkai-toki) - used in Kampo traditional herbal medicines, was studied by use of omics technologies. Complementary and alternative medical providers have observed in their clinical experience that differences in radix commercial quality reflect the differences in pharmacological responses; however, there has been little scientific examination of this phenomenon. The approach of omics, including metabolomics, transcriptomics, genomics, and informatics revealed a distinction between the radix-quality grades based on their metabolites,... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=5062884 Tue, 26 Jul 2011 11:00:02 +0100 5062884 http://www.medworm.com/index.php?rid=5062883&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21721156%26dopt%3DAbstract Authors: Chan PC, Peckham JC, Malarkey DE, Kissling GE, Travlos GS, Fu PP Ginseng is one of the most popular herbal supplements on the US market. Numerous reports of adverse effects from products containing ginseng have been filed with the US Food and Drug Administration (FDA) and the literature documents a "ginseng abuse syndrome" among regular users. However, the chronic toxic effects of ginseng are not well characterized. Because of its significant human exposure and the fact that little information on its toxicity is available, Panax ginseng was nominated by the US National Institutes of Health (NIH) to the US National Toxicology Program (NTP) to assess its carcinogenic potential. In this paper, we reported the results of NTP chronic toxicity and tumorigenicity bioassay. It shows t... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=5062883 Tue, 26 Jul 2011 11:00:02 +0100 5062883 http://www.medworm.com/index.php?rid=5062882&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21721157%26dopt%3DAbstract In this study, we investigated how ACA induced these enzymes by using rat intestine epithelial cells (IEC6) in vitro. ACA induced glutathione S-transferase (GST) and NAD (P)H: quinone oxidoreductase 1 (NQO1) activities, increased intracellular glutathione (GSH) level, and upregulated intranuclear Nrf2 and cytosolic p21. It suggested that activation of phase II enzymes via Nrf2 associated with p21 is one of possible mechanisms of ACA to prevent advance of carcinogenesis. PMID: 21721157 [PubMed - in process] (Source: The American Journal of Chinese Medicine) The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=5062882 Tue, 26 Jul 2011 11:00:02 +0100 5062882 http://www.medworm.com/index.php?rid=5062881&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21721158%26dopt%3DAbstract Authors: Chou PY, Huang GJ, Pan CH, Chien YC, Chen YY, Wu CH, Sheu MJ, Cheng HC Trilinolein has been identified as one of the active constituents isolated from Panax notoginseng used widely in traditional Chinese medicine. Protective actions of Panax notoginseng against cerebral ischemia, beneficial effects on the cardiovascular system, and hemostatic, antioxidant, hypolipidemic, hepatoprotective, renoprotective and estrogen-like activities have been illustrated. In the present study, the effects of trilinolein on the growth of non-small cell lung carcinoma A549 were investigated. It was found that the exposure of A549 cells to trilinolein resulted in the growth inhibition and the induction of apoptosis in a dose- and time- dependent manner. Trilinolein treatment induced the upregulati... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=5062881 Tue, 26 Jul 2011 11:00:02 +0100 5062881 http://www.medworm.com/index.php?rid=5062880&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21721159%26dopt%3DAbstract In conclusion, RHL could be a novel chemotherapeutic drug candidate for the treatment of human cervix cancer in the future. PMID: 21721159 [PubMed - in process] (Source: The American Journal of Chinese Medicine) The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=5062880 Tue, 26 Jul 2011 11:00:02 +0100 5062880 http://www.medworm.com/index.php?rid=5062879&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21721160%26dopt%3DAbstract Authors: Szeto YT, Wong SC, Wong JW, Kalle W, Pak SC Some traditional Chinese medicinal seeds and fruits are well known for their antioxidant properties. This research aims to investigate whether Fructus Lycii, Fructus Schisandrae Chinensis, Fructus Ligustri Lucidi and Semen Cuscutae protect DNA from oxidant challenge by hydrogen peroxide (H(2)O(2)). The standard comet assay was used to assess the genoprotective effect of these medicinal herbs. Blood was taken from three healthy adults, aged from 36 to 42. Lymphocytes were isolated and treated with different concentrations of aqueous herbal extracts, while controls were treated with phosphate buffered saline. The lymphocytes were stressed with 50 μM H(2)O(2). Treated cells were embedded in agarose and layered on slides. These sandwich... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=5062879 Tue, 26 Jul 2011 11:00:02 +0100 5062879 http://www.medworm.com/index.php?rid=4875631&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21598411%26dopt%3DAbstract Authors: Ernst E, Lee MS, Choi TY Acupuncture is often recommended for obstetrical and gynecological conditions but the evidence is confusing. We aim to summarize all recent systematic reviews in this area. Western and Asian electronic databases were searched for systematic reviews of any type of acupuncture for any type of gynecological conditions. Our own files were hand-searched. Systematic reviews of any type of acupuncture for any type of gynecological conditions were included. Non-systematic reviews and systematic reviews published before 2004 were excluded. No language restrictions were applied. Data were extracted according to predefined criteria and analysed narratively. Twenty-four systematic reviews were included. They relate to a wide range of gynecological conditions: hot ... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4875631 Sun, 29 May 2011 01:30:05 +0100 4875631 http://www.medworm.com/index.php?rid=4875630&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21598412%26dopt%3DAbstract This study used a randomized design with one control group and one experimental group consisting of Asian young adults with a waist circumference ≥80 cm in the females and ≥90cm in the males. At completion of eight weeks of auricular therapy, the total sample size was 55 young adults who ranged in age from 18 to 20 years old. Each participant was treated weekly for ear acupressure in ten-minute sessions. Sessions continued for eight weeks wherein the control group received acupressure only while the experimental group received acupressure with the Japanese Magnetic Pearl on the ear acupoints. While both the control and treatment groups showed significant reduction (p ≤ 0.05) to body weight and waist circumference after eight weeks of treatment, only the group treated with Japanese Ma... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4875630 Sun, 29 May 2011 01:30:05 +0100 4875630 http://www.medworm.com/index.php?rid=4875629&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21598413%26dopt%3DAbstract Authors: Jung HL, Kwak HE, Kim SS, Kim YC, Lee CD, Byurn HK, Kang HY The purpose of this investigation was to determine whether Panax ginseng extract intake would influence exercise-induced muscle damage and inflammation responses. Eighteen male college students were randomly assigned to either an RG intake group (RG, n = 9) or a placebo group (P, n = 9). All subjects performed a high-intensity uphill treadmill running task (two rounds of 45 min at 10 km/h speed with a 15 degree uphill slope separated by 5 min of rest). The RG group ingested 20 g/day of Korean red ginseng extract (mixed with 200 ml of water) three times/day for seven days prior to performing the uphill treadmill exercise test and for four days after the treadmill test, while the P group ingested 200 ml of water contain... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4875629 Sun, 29 May 2011 01:30:05 +0100 4875629 http://www.medworm.com/index.php?rid=4875628&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21598414%26dopt%3DAbstract In this study, we investigated its safety and its influence on quality of life (QOL) and the immune response in patients undergoing cancer chemotherapy. Seven patients were studied in total. The patients were undergoing postoperative adjuvant chemotherapy for breast cancer (n = 3) or gastrointestinal cancer (n = 2), or were receiving chemotherapy to prevent recurrence of gastrointestinal cancer (n = 2). The first course of treatment was chemotherapy alone and the second was chemotherapy plus concomitant administration of L.E.M. Adverse events and changes in the QOL score, lymphocyte subpopulations, lymphocyte activity and serum immune indices were evaluated during the study period. No adverse events attributable to L.E.M. were observed. Compared to the pre-chemotherapy state, no changes in... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4875628 Sun, 29 May 2011 01:30:05 +0100 4875628 http://www.medworm.com/index.php?rid=4875627&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21598415%26dopt%3DAbstract Authors: Wright PA, Innes KE, Alton J, Bovbjerg VE, Owens JE Upper respiratory tract infections (URIs) are a common complaint in competitive swimmers and can adversely affect performance. No intervention has yet been shown to reduce URI incidence in intensively trained athletes. The University of Virginia varsity swim team received three weeks of training in qigong for the purpose of reducing stress and improving health. Our primary objective was to assess the relationship between qigong practice and symptoms of URI during a time when swimmers would be at high URI risk. Secondary objectives were to assess degree of compliance with a qigong practice regimen, to evaluate differences between qigong practitioners and non-practitioners, and to determine the response-rate and reliability of ... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4875627 Sun, 29 May 2011 01:30:05 +0100 4875627 http://www.medworm.com/index.php?rid=4875626&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21598416%26dopt%3DAbstract In conclusion, these results support of the hypothesis that a natural herbal additive containing IgY can affect the immune regulation system and reduce the stress of microbial infections. PMID: 21598416 [PubMed - in process] (Source: The American Journal of Chinese Medicine) The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4875626 Sun, 29 May 2011 01:30:05 +0100 4875626 http://www.medworm.com/index.php?rid=4875625&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21598417%26dopt%3DAbstract Authors: Cheng J, Zhang PJ, Bao CQ, Gu YL, Xu BH, Li CW, Li JP, Bo P, Liu XN Atractylodes macrocephala polysaccharide (AMP), a traditional Chinese medicine, is thought to have protective effects against liver injury. Therefore, this study was designed to explore the effects of AMP on hepatic ischemia-reperfusion injury (IRI) and elucidate the possible mechanisms. Ninety-six Sprague-Dawley rats were randomly divided into four groups with 24 rats per group: a normal control group, an IRI group, an AMP-treated group (0.4 g/kg/d) and a bifendate-treated group (100 mg/kg). Rats were treated with AMP or bifendate once daily for seven days by gastric gavage. The normal control group and the IRI model group received an equivalent volume of physiological saline. At 1, 6 and 24 h after surgery, ... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4875625 Sun, 29 May 2011 01:30:05 +0100 4875625 http://www.medworm.com/index.php?rid=4875624&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21598418%26dopt%3DAbstract Authors: Chang TN, Ho YL, Huang GJ, Huang SS, Chen CJ, Hsieh PC, Chiang YC, Chang YS The hepatoprotective potential of Crossostephium chinensis (L.) Makino water extract (CCW) on carbon tetrachloride (CCl(4)) induced liver damage was evaluated in preventive and curative rat models. Not only were indicators of hepatic damage including GPT, GOT, lipid peroxides and TBARS were examined, the activities of antioxidant enzymes (SOD, CAT, GPx) and GSH were examined as well. The results showed that CCW (0.1, 0.5 and 1.0 g/kg) significantly reduced the elevated levels of GPT and GOT by CCl(4) administration (p < 0.05). TBARS level was dramatically reduced, and SOD, CAT, GPx and GSH activities were significantly increased. In addition, CCW decreased NO production and TNF-α activation in CCl(... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4875624 Sun, 29 May 2011 01:30:05 +0100 4875624 http://www.medworm.com/index.php?rid=4875623&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21598419%26dopt%3DAbstract Authors: Wu MF, Li PC, Chen CC, Ye SS, Chien CT, Yu CC Cordyceps Sobolifera (CS), an economic traditional Chinese herb, may ameliorate nephrotoxicity-induced renal dysfunction in the rat via antioxidant, anti-apoptosis, and anti-autophagy mechanisms. We investigated the water extract of fermented whole broth of CS on lipopolysaccharide (LPS)-induced renal cell injury in vitro and in vivo. CS effect on LPS-induced epithelial Lilly pork kidney (PK1) and Madin-Darby canine kidney epithelial (MDCK) cell death was detected with MTT assay. Two-month treatment of CS effects on renal blood flow (RBF), glomerular filtration rate (GFR), plasma blood urea nitrogen, creatinine level and leukocytes (WBC) count were determined in the LPS-treated rats. We further examined the effects of CS supplement... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4875623 Sun, 29 May 2011 01:30:05 +0100 4875623 http://www.medworm.com/index.php?rid=4875622&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21598420%26dopt%3DAbstract Authors: Tian XP, Yin YY, Li X Acremoniumterricola milleretal mycelium (AMM) is one of the most precious traditional Chinese medicines. It has numerous protective effects on organs, and has been used in Chinese herb prescription to treat refractory diseases. Our preliminary studies demonstrated that AMM had hepatoprotective activity in acute liver injury. We further investigated the effects of AMM on liver fibrosis in rats induced by carbon tetrachloride (CCl(4)) and explore its possible mechanisms. The animal model was established by injection with 50% CCl(4) subcutaneously in male Sprague-Dawley rats twice a week for eight weeks. Meanwhile, AMM (175, 350 and 700 mg/kg) was administered intragastrically per day until sacrifice. We found that treatment with AMM (175, 350 and 700 mg/kg)... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4875622 Sun, 29 May 2011 01:30:05 +0100 4875622 http://www.medworm.com/index.php?rid=4875621&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21598421%26dopt%3DAbstract This study attempted to access the neuroprotective effect of diosgenin on the senescent mice induced by d-galactose (D-gal). The mice in the experiments were orally administered with diosgenin (1, 5, 25 and 125 mg/kg), for four weeks from the sixth week. The learning and memory abilities of the mice in Morris water maze test and the mechanism involved in the neuroprotective effect of diosgenin on the mice brain tissue were investigated. Diosgenin (5, 25 and 125 mg/kg, p.o.) showed significantly improved learning and memory abilities in Morris water maze test compared to D-gal treated mice (200 mg/kg, ten weeks). Diosgenin also increased the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), and decreased the malondialdehyde (MDA) level in the brain of D-gal treat... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4875621 Sun, 29 May 2011 01:30:05 +0100 4875621 http://www.medworm.com/index.php?rid=4875620&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21598422%26dopt%3DAbstract In this study, we investigate the protective effect of CO in dextran sulfate sodium (DSS)-induced colitis. CO reduced clinical signs of DSS-induced colitis, including body weight loss, shortened colon length, and increased disease activity index. The results show that CO significantly suppressed the levels of interleukin (IL)-6 and expression of cyclooxygenase-2 in DSS-treated colon tissues. Additionally, we observed that CO reduced the activation of transcription nuclear factor-κB p65 in DSS-treated colon tissues. Taken together, these findings suggest that CO has improving effects on DSS-induced ulcerative colitis, which may explain its beneficial effect in the regulation of chronic intestinal inflammation. PMID: 21598422 [PubMed - in process] (Source: The American Journal of Chines... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4875620 Sun, 29 May 2011 01:30:05 +0100 4875620 http://www.medworm.com/index.php?rid=4875619&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21598423%26dopt%3DAbstract Authors: Xu Z, Chen X, Zhang Q, Chen L, Wang Y Corydalis yanhusuo W.T. Wang (YHS) is a traditional Chinese herb widely prescribed for promoting blood circulation, reinforcing vital energy and alleviating pain. Our previous studies showed that an ethanol extract of YHS inhibits metastasis of breast cancer cells in vitro. In the present study, the anti-proliferative effect of the extract was determined by MTT assay and the LDH release was measured with a commercial kit. Intracellular reactive oxygen species (ROS) production and mitochondrial membrane potential (ΔΨm) were monitored by CM- H(2)DCF-DA and JC-1 staining, respectively. Cell cycle was analyzed with propidium iodide (PI) staining by flow cytometry and protein expressions were measured by Western blotting. The YHS extract sign... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4875619 Sun, 29 May 2011 01:30:05 +0100 4875619 http://www.medworm.com/index.php?rid=4875618&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21598424%26dopt%3DAbstract Authors: Kim SJ, Myung NY, Shin BG, Lee JH, So HS, Park RK, Um JY, Hong SH Chungshinchongyitang (CSCYT) is an herbal drug formula containing Chrysanthemum indicum and 13 other herbs used for treating auditory diseases. Irreversible hearing loss is a characteristic effect of a number of heavy metals. Cadmium (Cd(2+)) is an environmental contaminant that causes a variety of adverse effects. In the present study, we investigate the protective effects of CSCYT against Cd(2+) induced ototoxicity in vitro and ex vivo. The findings of this study show that CSCYT prevents the destruction of hair cell arrays induced by Cd(2+) in the rat organ of Corti primary explants. CSCYT inhibited cell death, release of cytochrome c and generation of reactive oxygen species induced by Cd(2+) in HEI-OC1 audit... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4875618 Sun, 29 May 2011 01:30:05 +0100 4875618 http://www.medworm.com/index.php?rid=4875617&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21598425%26dopt%3DAbstract Authors: Kim YI, Park SW, Choi IH, Lee JH, Woo HJ, Kim Y Orostachys japonicus (O. japonicus), used to treat diseases such as various cancers, gastric ulcers, fever, hepatitis, arthritis, eczema, for hemostasis, and intoxication in folk medicine, has been an important constituent in many herbal formulae. We demonstrated that the water extract of O. japonicus led to growth inhibition of LX2 cells by inducing apoptosis through the caspase activation, related to the MAPK pathway. O. japonicus inhibited proliferation of LX2 cells in a dose- and time-dependent manner, increased the apoptosis fraction at cell cycle progression with an accompanying DNA fragmentation, and resulted in a significant decrease in Bcl-2 and an increase in Bax mRNA levels. Exposure of LX2 cells to O. japonicus induce... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4875617 Sun, 29 May 2011 01:30:05 +0100 4875617 http://www.medworm.com/index.php?rid=4875616&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21598426%26dopt%3DAbstract This study was designed to examine antioxidant activities, antiglycating abilities and neuroprotective effects of methanolic extracts of Salvia choloroleuca, Salvia santolinifolia and Salvia mirzayanii from Iran. The extracts were screened for their possible antioxidant activities by several biochemical assays such as DPPH, FRAP, β-carotene bleaching and TEAC assays. HPLC analysis of these extracts led to the separation of a number of components such as catechine and rosmarinic acid. Based on our results, all these plants had antioxidant and antiglycating activities, among them S. choloroleuca seems to be the most effective one. Furthermore, these species not only showed no cytotoxic effects in neuron-like PC12 cells, but also protected them against oxidative stress-induced cell death, ex... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4875616 Sun, 29 May 2011 01:30:05 +0100 4875616 http://www.medworm.com/index.php?rid=4715554&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21476200%26dopt%3DAbstract This article reviews the physiological and therapeutic effects of ginger and turmeric on some endocrine gland functions, and signal pathways involved to mediate their actions. With some systems and adipose tissue, ginger and turmeric exert their actions through some/all of the following signals or molecular mechanisms: (1) through reduction of high levels of some hormones (as: T4, leptin) or interaction with hormone receptors; (2) by inhibition of cytokines/adipokine expression; (3) acting as a potent inhibitor of reactive oxygen species (ROS)-generating enzymes, which play an essential role between inflammation and progression of diseases; (4) mediation of their effects through the inhibition of signaling transcription factors; and/or (5) decrease the proliferative potent by down-regulati... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4715554 Fri, 15 Apr 2011 16:45:03 +0100 4715554 http://www.medworm.com/index.php?rid=4715553&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21476201%26dopt%3DAbstract Authors: Lin ZP, Chen YH, Chia F, Wu HJ, Lan LW, Lin JG Wrestling normally places extreme demands on the body and thus may cause various kinds of injuries. An in-depth understanding of the episodes of injured sites, types, timings, and treatment modalities would help participants be aware of wrestling-related injury occurrences so as to develop effective preventive measures. Therefore, this study aims to investigate the gender-specific injuries among elite wrestling athletes. Subjects were selected from the 2009 Taiwanese National Wrestling Sport Championship. Participants were adolescent wrestling athletes, ages 16-18, who must have received at least one bronze medal at national level tournaments in 2008. A total of 118 respondents, 96 males and 22 females, completed and returned the ... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4715553 Fri, 15 Apr 2011 16:45:03 +0100 4715553 http://www.medworm.com/index.php?rid=4715552&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21476202%26dopt%3DAbstract Authors: Kim E, Cho JH, Jung WS, Lee S, Pak SC Primary dysmenorrhea is a common gynecological complaint among young women that is related to an autonomic nervous system (ANS) disturbance. Acupuncture is one of several therapeutic approaches for primary dysmenorrhea, since it can modulate ANS function. The heart rate variability (HRV) parameters such as high frequency (HF), low frequency (LF) and LF/HF ratio are generally accepted tools to assess ANS activity. The purpose of this study was to investigate the effects of acupuncture applied at Hegu (LI4) and Sanyinjiao (SP6) points on HRV of women with primary dysmenorrhea during the late luteal phase. The experimental design was a crossover and patient-blinded procedure. All subjects participated in Sham (SA) and Real Acupuncture (RA) pr... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4715552 Fri, 15 Apr 2011 16:45:03 +0100 4715552 http://www.medworm.com/index.php?rid=4715551&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21476203%26dopt%3DAbstract Authors: Guan H, Koceja DM The purpose of the present study was to examine the effects of long-term Tai Chi practice on postural balance and H-reflex. Sixteen healthy volunteers, eight with three or more years of experience in Tai Chi training (Tai Chi Group-TCG), and eight with no experience in Tai Chi training (Control Group-CG) participated in the study. Postural sways were measured under four experimental conditions: (1) Standing still with eyes open (EO); (2) Standing still with eyes closed (EC); (3) Standing and turning head to left and right with eyes open (EOT); and (4) Standing and turning head to left and right with eyes closed (ECT). Paired reflex depression (PRD) of the soleus muscle was measured under two conditions: supine and standing. Less significant postural sway was ... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4715551 Fri, 15 Apr 2011 16:45:03 +0100 4715551 http://www.medworm.com/index.php?rid=4715550&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21476204%26dopt%3DAbstract In conclusion, BS particles could be used as the embolic material in PSE. Compared to gelfoam used in PSE, BS can achieve even better efficacy in alleviating hypersplenism. It provides a long-term effect on the hematological parameters, bleeding from esophageal varices and good palliation, and improved clinical status contributing to symptomatic control. PMID: 21476204 [PubMed - in process] (Source: The American Journal of Chinese Medicine) The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4715550 Fri, 15 Apr 2011 16:45:03 +0100 4715550 http://www.medworm.com/index.php?rid=4715549&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21476205%26dopt%3DAbstract In this study, 135 subjects including the controls, Dyspepsias and Rhinitis were enrolled in this study. The signals were taken from three diagnosis positions of both wrists. Seven parameters of pressure wave and two parameters of spectrum analysis were evaluated by ANOVA test and Tukey's test. The results showed that the effects of detection time and position on the parameters taken from pulse wave were inconsistent. No regular rules or relationship could be established. The power spectra of 10-50 Hz and 13-50 Hz from sphygmography revealed a significant effect of health status, position and their interaction. There was a significant difference in the power spectra of 13-50 Hz between the control and Rhinitis, as well as between the control and Dyspepsia at right Guan position. The result... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4715549 Fri, 15 Apr 2011 16:45:03 +0100 4715549 http://www.medworm.com/index.php?rid=4715548&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21476206%26dopt%3DAbstract Authors: Wen SL, Liu YJ, Yin HL, Zhang L, Xiao J, Zhu HY, Xue JT, Ye LM Acute gouty arthritis is a common inflammation model with multiple pathogenic mechanisms seen in clinical practice, for which acupuncture may potentially be an alternative therapy. To investigate the effect of acupuncture on acute gouty arthritis and search for its mechanism, a metabonomic method was developed in this investigation. Acute gouty arthritis model rats were induced by monosodium urate (MSU) crystals. The urine and plasma samples were collected at several time points and the endogenous metabolites were analyzed by an ultra-performance liquid chromatography coupled with a mass spectrometry (UPLC-MS). Data were analyzed using principal components analysis (PCA) and partial least squares (PLS) analysis to ... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4715548 Fri, 15 Apr 2011 16:45:03 +0100 4715548 http://www.medworm.com/index.php?rid=4715547&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21476207%26dopt%3DAbstract In this study, we investigated the effects of a Chinese herbal medicine formula Xiao-Gao-Jiang-Zhuo (XGJZ) in obese rats induced by a high-fat diet. Ten male rats in the normal group were fed with a standard diet. Another 50 male obese rats were induced by a 12-week high-fat diet feeding, and were randomly divided into five groups (n = 10 per group): the model group, the high-dose XGJZ group, the middle-dose XGJZ group, the low-dose XGJZ group, and the sibutramine group. After 14 weeks of treatment, body weight, abdominal fat, blood lipid and serum insulin level were measured, and the protein and gene expression of PTP1B in liver tissue was tested. Our data showed that the body weight of the high-dose and middle-dose groups and the sibutramine group had significant differences in compariso... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4715547 Fri, 15 Apr 2011 16:45:03 +0100 4715547 http://www.medworm.com/index.php?rid=4715546&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21476208%26dopt%3DAbstract Authors: Koh PO EGb 761 is a standardized extract of Ginkgo biloba that appears to have a neuroprotective effect against neurodegenerative diseases. Adult male rats were treated with EGb 761 (100 mg/kg) or vehicle prior to middle cerebral artery occlusion (MCAO), and brains were collected 24 h after MCAO. Proteins that were differentially expressed after EGb 761 treatment during cerebral ischemia were detected using two-dimensional gel electrophoresis. Protein spots with more than a 2.5-fold change in intensity between vehicle- and EGb 761-treated groups were identified by mass spectrometry. The levels of peroxiredoxin-2 and protein phosphatase 2A subunit B were significantly decreased in the vehicle-treated group in comparison to the EGb 761-treated group. In contrast, levels of the c... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4715546 Fri, 15 Apr 2011 16:45:03 +0100 4715546 http://www.medworm.com/index.php?rid=4715545&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21476209%26dopt%3DAbstract Authors: Yan LG, Lu Y, Zheng SZ, Wang AY, Li MQ, Ruan JS, Zhang L The present study aimed to investigate the protective effects of injectable caltrop fruit saponin preparation (ICFSP) on ischemia-reperfusion injury in rat brain. Rats were injected with ICFSP and then subjected to cerebral ischemia-reperfusion injury induced by middle cerebral artery occlusion. Then the neurological deficit score was evaluated by Bederson's method. The infarct size was assessed by TTC staining. The content of malondialdehyde (MDA) and nitric oxide (NO), and the activity of superoxide dismutase (SOD) in rat cerebrum were measured with kits, and the content of 6 K prostaglandin F1α (6-K-PGF 1α), thromboxane B2 (TXB2) and endothelin (ET) in blood plasma was measured by radioimmunoassay. The results demon... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4715545 Fri, 15 Apr 2011 16:45:03 +0100 4715545 http://www.medworm.com/index.php?rid=4715544&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21476210%26dopt%3DAbstract In conclusion, LM is a potential analgesic and anti-inflammatory Ligustrum plant, and its anti-inflammatory effects are partially related to decreasing microvascular permeability via inflammatory mediators and inhibiting cyclooxygenase-2 activity. PMID: 21476210 [PubMed - in process] (Source: The American Journal of Chinese Medicine) The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4715544 Fri, 15 Apr 2011 16:45:03 +0100 4715544 http://www.medworm.com/index.php?rid=4715543&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21476211%26dopt%3DAbstract This study investigated the protective effect of the aqueous extract of Flemingia macrophylla (AFM) against hepatic injury induced by CCl(4). Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were detected as biomarkers in the blood to indicate hepatic injury. Product of lipid peroxidation (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), and reduced glutathione (GSH) contents were evaluated for oxidative stress in hepatic injury. Moreover, histopathological observation was assayed for the degree of hepatic injury. After oral administration of AFM, 0.5 g/kg and 1.0 g/kg doses significantly decreased ALT and AST, attenuated the histopathology of hepatic injury, ameliorated oxidative stress in hepatic tissue, and increased the activities of... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4715543 Fri, 15 Apr 2011 16:45:03 +0100 4715543 http://www.medworm.com/index.php?rid=4715542&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21476212%26dopt%3DAbstract In this study, to further identify the physiological effects of Corni Fructus against diabetes and its complications, we investigated α-glucosidase inhibitory activities in vitro and employed the sucrose tolerance test as an indicator of the control of the postprandial blood glucose level. In vitro assays showed that Corni Fructus extract has a higher inhibitory activity than its major components. Then, Corni Fructus extract was fractionated again to screen the fractions showing a strong inhibitory activity against α-glucosidase. Of the tested fractions, five showed a rate of α-glucosidase inhibition of over 80%. Next, the four abundant fractions were evaluated their IC(50) values, as well as the inhibition mode in vitro and plasma glucose level after sucrose loading in normal Wistar ra... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4715542 Fri, 15 Apr 2011 16:45:03 +0100 4715542 http://www.medworm.com/index.php?rid=4715541&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21476213%26dopt%3DAbstract Authors: Chan P, Liu JC, Lin LJ, Chen PY, Cheng TH, Lin JG, Hong HJ Tanshinone IIA extracted from Danshen, a popular medicinal herb used in traditional Chinese medicine, exhibits cardio-protective effects. However, the mechanism of its cardioprotective effect is not well established. The aims of this study were to examine whether tanshinone IIA may alter angiotensin II (Ang II)-induced cell proliferation and to identify the putative underlying signaling pathways in rat cardiac fibroblasts. Cultured rat cardiac fibroblasts were pre-treated with tanshinone IIA and stimulated with Ang II, cell proliferation and endothelin-1 (ET-1) expression were examined. The effect of tanshinone IIA on Ang II-induced reactive oxygen species (ROS) formation, and extracellular signal-regulated kinase (ERK... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4715541 Fri, 15 Apr 2011 16:45:03 +0100 4715541 http://www.medworm.com/index.php?rid=4715540&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21476214%26dopt%3DAbstract Authors: Liu X, Wang Y, Ma C, Zhang L, Wu W, Guan S, Yang M, Wang J, Jiang B, Guo DA Although doxorubicin (DXR) is an important antineoplastic agent, the serious toxicity mediated by the production of reactive oxygen species has remained a considerable clinical problem. Our hypothesis is that tanshinone II A sodium sulfonate (TSNIIA-SS), which holds significant effects against oxidative stress, protects against DXR-induced nephropathy. Firstly, the antioxidative effects of TSNIIA-SS were confirmed using oxygen radicals absorbance capacities (ORAC) assay in vitro. Then, DXR nephropathy was induced by repeated DXR treatment and verified by kidney index (20.76 ± 3.04 mg/mm versus 14.76 ± 3.04 mg/mm, p < 0.001) and histochemical stain. The mice were randomized into three groups: Contr... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4715540 Fri, 15 Apr 2011 16:45:03 +0100 4715540 http://www.medworm.com/index.php?rid=4715539&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21476215%26dopt%3DAbstract Authors: Yang ZY, Pan SL, Huo KK, Wu BY, Chao Z The genus Leonurus has long been recognized as a natural group, but its interspecific relationship has not yet been studied in the light of sequence data. The ITS regions and matK sequences of all subgenera of Leonurus in China were amplified, sequenced and investigated. Phylogenies generated by maximum parsimony and neighbor-joining methods and division of the genus into two major clades. The phylogenetic results indicated that L. chaituroides has the very close phylogenetic relationship with Subg. Cardiochilium and supported the notion that L. macranthus acts as the bridge between Subg. cardiochilium and Subg. Leonurus. According to the analysis of information given by ITS and matK sequences, we suggest that ITS sequences would be more ... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4715539 Fri, 15 Apr 2011 16:45:03 +0100 4715539 http://www.medworm.com/index.php?rid=4353144&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21213394%26dopt%3DAbstract Authors: Liu Q, Lawrence AJ, Liang JH Alcohol has long been used as a daily beverage in China and around the world. It is a medicinal substance with various biological activities. In fact, alcohol has played an important role in the development of traditional Chinese medicine (TCM), within which it is considered as the earliest exhilarant and anaesthetic. Yet, as a substance with great potency of misuse and addiction, the consumption of alcohol can lead to serious damage to individual health and the society. Over the past 20 years, alcohol abuse or alcoholism has become an increasing social problem in China along with the rapid economic development. China, the country of origin for TCM, has accumulated abundant clinical experience in the treatment of alcoholism with its ancient medicin... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4353144 Sun, 16 Jan 2011 13:00:08 +0100 4353144 http://www.medworm.com/index.php?rid=4353143&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21213395%26dopt%3DAbstract Authors: Xu Z, Chen X, Zhong Z, Chen L, Wang Y Ganoderma lucidum (G. lucidum), a basidiomycete white rot fungus, has long been prescribed to prevent and treat various human diseases, particularly in China, Japan, and Korea. Several classes of bioactive substances have been isolated and identified from G. lucidum, such as triterpenoids, polysaccharides, nucleosides, sterols, and alkaloids, among others. This paper examines the potential role of G. lucidum polysaccharide (GLPS) in tumor therapy and the possible mechanisms involved. Both in vitro and in vivo studies suggested that the anti-tumor activities of GLPS are mediated by its immunomodulatory, anti-angiogenic, and cytotoxic effects. GLPS affects immune cells and immune-related cells including B lymphocytes, T lymphocytes, dendriti... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4353143 Sun, 16 Jan 2011 13:00:08 +0100 4353143 http://www.medworm.com/index.php?rid=4353142&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21213396%26dopt%3DAbstract Authors: Raith W, Kutschera J, Müller W, Urlesberger B The aim of the study was to determine the presence of acupuncture ear points in neonates with Neonatal Abstinence Syndrome (NAS). NAS occurs in the first days of life in neonates whose mothers have a history of drug abuse, and may also occur in neonates whose mothers are currently following substitution therapy. The patients are neonates with NAS admitted over one year to the Division of Neonatology at the University Hospital Graz. The examination took place on the third day after delivery (mean value 70.3 hours) and was performed by a neuronal pen (PS 3 © Silberbauer, Vienna, Austria). An integrated sound and optical signal detected the active ear points that were then placed on an ear map. We investigated six neonates (four mal... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4353142 Sun, 16 Jan 2011 13:00:08 +0100 4353142 http://www.medworm.com/index.php?rid=4353141&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21213397%26dopt%3DAbstract Authors: Lee YJ, Choi DH, Kim EJ, Kim HY, Kwon TO, Kang DG, Lee HS Morus alba L. has been used in traditional Chinese medicine and almost all parts of this plant are useful in cardiovascular, liver and spleen disorders. The present study was designed to investigate the inhibitory effect of a water extract from Morus alba L. (WMA) on vascular dysfunction in rat models fed a high fat and high cholesterol diet. Male rats were fed an atherogenic diet consisting of food with 7.5% cocoa butter and 1.25% cholesterol, with or without 100 or 200 mg/day/kg WMA, for 14 weeks. Chronic treatment with low (100 mg/kg/day) or high (200 mg/day/kg) doses of WMA markedly attenuated hypertension and the impairments of acetylcholine-induced relaxation of aortic rings in rats fed an atherogenic diet. WMA re... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4353141 Sun, 16 Jan 2011 13:00:08 +0100 4353141 http://www.medworm.com/index.php?rid=4353140&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21213398%26dopt%3DAbstract Authors: Zhen Z, Chang B, Li M, Lian FM, Chen L, Dong L, Wang J, Yu B, Liu WK, Li XY, Qin PJ, Zhang JH, Tong XL The Chinese formula Tang-Min-Ling (TML), an improved product of the decoction of Dachaihu which has a history of more than 2000 years, has main constituents of Coptis chinensis Franch, Scutellaria baicalensis Georgi, Rheum officinale Baill and Bupleurum chinense DC. A multi-central randomized controlled investigation performed previously by us has showed that TML has positive effects on regulating glycometabolism in type 2 diabetes (T2DM) patients, but the mechanisms remain unclear. Using Otsuka Long-Evans Tokushima Fatty (OLETF) rats as an animal model with rosiglitazone as a positive control, we were able to detect TML's effect on the serum glucose, serum lipid, serum lepti... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4353140 Sun, 16 Jan 2011 13:00:08 +0100 4353140 http://www.medworm.com/index.php?rid=4353139&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21213399%26dopt%3DAbstract Authors: Xu JX, Yang M, Deng KJ, Zhou H The aim of this study was to investigate the effect of a BuOH-soluble fraction from Dracocephalum tanguticum Maxim (DME), which contained 52% of total flavonoid, on the cerebral ischemia injury induced by permanent middle cerebral artery occlusion (pMCAO) in rats. RT-PCR and Western blot analysis showed that DME (30 mg/kg/day for seven days) by intragastric administration modulated the mRNA expression and protein synthesis of two neurotrophic factors: brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT-3). DME was effective in stimulating BDNF mRNA expression and protein synthesis in the ipsilateral frontal cortex (IFC) of both the sham-operated and pMCAO rats and this effect was also observed in the hippocampus of the pMCAO rats. DME... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4353139 Sun, 16 Jan 2011 13:00:08 +0100 4353139 http://www.medworm.com/index.php?rid=4353138&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21213400%26dopt%3DAbstract This study aims to identify the therapeutic effect of Korean red ginseng (KRG) on the expression of inflammatory cytokines in rats with focal cerebral ischemia/reperfusion injury. Adult male Sprague-Dawley rats were subjected to transient middle cerebral artery occlusion (tMCAO) for two hours. They were fed KRG extract (100 mg/kg/day per orally) or saline after reperfusion. Tests for neurological deficits, using the modified neurologic severity score and the corner turn test, were performed before the ischemic event, and one, three, and seven days after tMCAO. Serum levels of cytokines were measured three and seven days after the operation, using enzyme-linked immunosorbent assays. The infarct volume was assessed after seven days by staining brain tissue with 2% 2, 3, 5-triphenyltetrazoliu... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4353138 Sun, 16 Jan 2011 13:00:08 +0100 4353138 http://www.medworm.com/index.php?rid=4353137&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21213401%26dopt%3DAbstract This study describes the metabonomics of fevers in animal models and the therapeutic effects of Rhizoma coptidis extract (RCE) on them. The rat urinary samples were analyzed by UPLC/ ESI-Q-TOF/MS, combined with principal component analysis (PCA). Nine ions were chosen to characterize the similarities and differences in the responses to fever. The ion at m/z 206.0278 was unambiguously identified to be xanthurenic acid. This study demonstrated that the metabonomic approach can readily distinguish between febrile and healthy individuals. This data support the contention that the metabonomic approach represents a promising new technology for the development of rapid-throughput in vivo fever screening. Furthermore, this approach can detect the interfering effects of RCE. This investigation has ... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4353137 Sun, 16 Jan 2011 13:00:08 +0100 4353137 http://www.medworm.com/index.php?rid=4353136&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21213402%26dopt%3DAbstract In conclusion, the study demonstrated that the inhibition of granulocyte adherence is one of the targets of Sal A in the treatment of ischemic stroke. Meanwhile, Sal A inhibits of granulocyte adherence by decreasing the expression of ICAM-1 in BMEC. PMID: 21213402 [PubMed - in process] (Source: The American Journal of Chinese Medicine) The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4353136 Sun, 16 Jan 2011 13:00:08 +0100 4353136 http://www.medworm.com/index.php?rid=4353135&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21213403%26dopt%3DAbstract In this study, we analyzed the combined cytotoxic effect of triptolide and hydroxycamptothecin (HCPT) on pancreatic cancer cell line PANC-1 by using 3-(4.5-dimethylthiazol-2-yl)-5-(3-carboxy-methoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, inner salt (MTS) and fluorescence- activated cell sorting (FACS) assays. Our results showed that the sensitivity of a combined therapy using triptolide and HCPT was higher than that of triptolide or HCPT alone and that activation of caspase-9/caspase-3 and inhibition of nuclear factor-kappaB (NF-κB) signaling pathway may contribute to the synergistic cytotoxic effect of this combination therapy. Therefore, our observations provided evidence supporting the clinical applications of the combination chemotherapy using triptolide and HCPT for treating pancre... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4353135 Sun, 16 Jan 2011 13:00:08 +0100 4353135 http://www.medworm.com/index.php?rid=4353134&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21213404%26dopt%3DAbstract Authors: Zhang G, Zeng X, Li C, Li J, Huang Y, Han L, Wei JA, Huang H The study aimed to evaluate inhibition effect of sclerotia of Polyporus umbellatus Fries aqueous extract (SPUE) and polyporus polysaccharide (PPS) on bladder cancer, then to measure their effect on mRNA expression of glutathione S-transferase π (GSTPi) and NAD(P)H:quinone oxidoreductase 1 (NQO1) in female Fischer-344 rats model. The model rats were induced by N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) for a period of 8 weeks and saccharin for 12 weeks. SPUE (50 mg/kg, 250 mg/kg, 500 mg/kg) and PPS (28 mg/kg) were orally administrated to the model rats during the whole study. Compared to the control group, a more preventive effect of SPUE and PPS treatment on bladder cancer was discovered, higher mRNA upregulation ... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4353134 Sun, 16 Jan 2011 13:00:08 +0100 4353134 http://www.medworm.com/index.php?rid=4353133&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21213405%26dopt%3DAbstract In this study, we investigated the effect of RSVL and a PKC inhibitor (DL-erythro-1,3-Dihydroxy-2-aminooctadecane, PKCI) on platelet aggregation induced by a thromboxane A(2) receptor agonist (U46619, 9,11-Dideoxy-11α, 9α-epoxymethanoprostaglandin F(2α)) using a platelet aggregometer. We also studied the platelet membranebound fibrinogen (PFig) content and the activity of protein kinase C (PKC) in platelets from healthy volunteers using flow cytometry, and a phosphorimaging system, respectively. Our results showed that RSVL blocked platelet aggregation and PFig content induced by U46619 in a concentration-dependent manner. PKCI and RSVL had an additive effect in inhibiting platelet aggregation and PFig content. Furthermore, RSVL (final concentration 50 μM) remarkably depressed the acti... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4353133 Sun, 16 Jan 2011 13:00:08 +0100 4353133 http://www.medworm.com/index.php?rid=4353132&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21213406%26dopt%3DAbstract Authors: Kim KC, Lee IK, Kang KA, Kim BJ, Kim D, Moon JY, Yoo BS, Hyun JW The ethylacetate fraction of Empetrum nigrum var. japonicum (ENE) was shown to reduce intracellular reactive oxygen species (ROS) generated by γ-radiation and activate antioxidant enzymes, such as superoxide dismutase (SOD), catalase (CAT), and gluthathion peroxidase (GPx). ENE protected cells against radiation-induced cellular DNA damage, membrane lipid peroxidation, and protein modification, which are the main points of radiation-induced damage. In addition, ENE recovered cell viability by inhibiting apoptosis after cells were treated with radiation. ENE treatment also reduced γ-radiation induced Bax, and caspase 9 and 3 expression in irradiated cells. However, irradiated cells with ENE recovered Bcl-2 expres... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4353132 Sun, 16 Jan 2011 13:00:08 +0100 4353132 http://www.medworm.com/index.php?rid=4353131&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21213407%26dopt%3DAbstract In this study, hyperoside was shown to exert an anti-inflammatory action through suppressed production of tumor necrosis factor, interleukin-6, and nitric oxide in lipopolysaccharide-stimulated mouse peritoneal macrophages. The maximal inhibition rate of tumor necrosis factor-α, interleukin-6, and nitric oxide production by 5 μM hyperoside was 32.31 ± 2.8%, 41.31 ± 3.1%, and 30.31 ± 4.1%, respectively. In addition, hyperoside inhibited nuclear factor-κB activation and IκB-α degradation. The present study suggests that an important molecular mechanism by hyperoside reduces inflammation, which might explain its beneficial effect in the regulation of inflammatory reactions. PMID: 21213407 [PubMed - in process] (Source: The American Journal of Chinese Medicine) The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4353131 Sun, 16 Jan 2011 13:00:08 +0100 4353131 http://www.medworm.com/index.php?rid=4353130&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21213408%26dopt%3DAbstract In conclusion, the M. calabura leaves possess potential antiproliferative and antioxidant activities that could be attributed to its high content of phenolic compounds, and thus, needs to be further explored. PMID: 21213408 [PubMed - in process] (Source: The American Journal of Chinese Medicine) The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4353130 Sun, 16 Jan 2011 13:00:08 +0100 4353130 http://www.medworm.com/index.php?rid=4353129&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21213409%26dopt%3DAbstract This study also used high-performance liquid chromatography (HPLC) to determine the quality control of H. diffusa. The HPLC data showed that ursolic and oleanolic acid are the components of the H. diffusa, consisting of approximately 4.66-4.80% and 1.86-1.96%, respectively. Our study also demonstrated that ursolic acid has significant anti-tumor activity in COLO 205, Hep 3B and H460 cancer cells. PMID: 21213409 [PubMed - in process] (Source: The American Journal of Chinese Medicine) The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4353129 Sun, 16 Jan 2011 13:00:08 +0100 4353129 http://www.medworm.com/index.php?rid=4156755&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21061457%26dopt%3DAbstract Authors: Han HJ, Yoon HY, Kim JY, Jang HY, Lee B, Choi SH, Jeong SW The clinical efficacy of electroacupuncture and acupuncture in combination with medication for the treatment of thoracolumbar intervertebral disc herniation was investigated in paraplegic dogs with intact deep pain perception. To evaluate the additional effect of electroacupuncture, dogs treated with conventional medicines alone were compared to dogs treated with electroacupuncture and acupuncture and conventional medicine. Medical records of 80 dogs were reviewed for this investigation and classified into two groups undergoing different treatment methods: (1) treatment with conventional medicine alone (Group C, n = 37) and (2) treatment with conventional medicine combined with electroacupuncture and acupuncture (Group... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4156755 Fri, 12 Nov 2010 07:00:03 +0100 4156755 http://www.medworm.com/index.php?rid=4156754&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21061458%26dopt%3DAbstract Authors: Sang Z, Zhou L, Fan X, McCrimmon RJ Radix astragali is a herbal remedy used in China to treat patients with diabetes exposed to repeated episodes of hypoglycemia. The physiological basis or validity of this approach is not clear. In the present study, we examine the effect of pre-treatment with Radix astragali on hormonal counterregulatory responses to hypoglycemia in normal male Sprague-Dawley rats. Four groups of rodents were studied. In two of these groups, rodents were pre-treated for 3 days with either intravenous Radix astragali or control solution and, subsequently, while awake and unrestrained, underwent an in vivo hyperinsulinemic hypoglycemic (50 mg/dl) clamp study. The rodents in other two groups were pre-treated for 7 days with either intravenous Radix astragali or... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4156754 Fri, 12 Nov 2010 07:00:03 +0100 4156754 http://www.medworm.com/index.php?rid=4156753&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21061459%26dopt%3DAbstract In this study, we examined the anti-arthritis effects of melittin, which composes nearly 50% of the dry weight of whole BV, on the complete Freund's adjuvant-induced (CFA-induced) RA model in rats. The RA animal models were treated with solutions of BV, melittin, and saline by injection into a specific acupoint (Zusanli). The BV and melittin treatments statistically diminished the thickness of the arthroses in the injected side of the paw, compared to the saline treatment. Melittin therapy also significantly reduced arthritis-induced nociceptive behaviors, as assessed by the thermal hyperalgesia test. In addition, CFA-induced Fos expression in the superficial layer of the lumbar spinal cord was significantly suppressed by the BV and melittin treatments, compared to the saline treatment. Th... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4156753 Fri, 12 Nov 2010 07:00:03 +0100 4156753 http://www.medworm.com/index.php?rid=4156752&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21061460%26dopt%3DAbstract Authors: Al-Dosari MS The ethanolic extract of Amaranthus tricolor L. (ATE) leaves was tested for its efficacy against CCl(4)-induced liver toxicity in rats. The hepatoprotective activity of ATE was evaluated via measuring various liver toxicity parameters, the lipid profile, and a histopathological evaluation. A sleeping time determination study and an acute toxicity test were performed in mice. The results clearly showed that oral administration of ATE for three weeks significantly reduced the elevated levels of serum GOT, GPT, GGT, ALP, bilirubin, cholesterol, LDL, VLDL, TG, and MDA induced by CCl(4). Moreover, ATE treatment was also found to significantly increase the activities of NP-SH and TP in liver tissue. These biochemical findings have been supported by the evaluation of the... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4156752 Fri, 12 Nov 2010 07:00:03 +0100 4156752 http://www.medworm.com/index.php?rid=4156751&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21061461%26dopt%3DAbstract This study explores the effects of 3'-deoxyadenosine, a compound from Cordyceps militaris, on lipid metabolic disorder induced by a high-fat-diet in C57BL/6 mice. These mice had an obese body, lipid metabolic disorder and insulin resistance and were treated orally with 100 mg/kg/day 3'-deoxyadenosine (DA), 15 mg/kg/day rosiglitazone and 150 mg/kg/day fenofibrate, respectively. Compared to the model mice, the body weight gain in DA-treated mice were decreased by 66.5%, serum triglyceride and total cholesterol levels were decreased by 20.7% and 16.7%, respectively, and the triglyceride content in the skeletal muscle was reduced by 41.2%. This treatment also had a significant effect on insulin resistance. In DA-treated mice, the serum insulin levels and homeostasis model assessment of the ins... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4156751 Fri, 12 Nov 2010 07:00:03 +0100 4156751 http://www.medworm.com/index.php?rid=4156750&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21061462%26dopt%3DAbstract In conclusion, BV has anti-atherogenic properties via its lipid-lowering and anti-inflammatory mechanisms. PMID: 21061462 [PubMed - in process] (Source: The American Journal of Chinese Medicine) The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4156750 Fri, 12 Nov 2010 07:00:03 +0100 4156750 http://www.medworm.com/index.php?rid=4156749&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21061463%26dopt%3DAbstract This study was performed to investigate the effects of polysaccharides from cultivated fruiting bodies of C. militaris (CMP) on mitochondrial injury, antioxidation and anti-aging activity. Fruiting bodies of C. militaris were cultivated artificially under optimized conditions. The spectrophotometric method was used to measure thiobarbituric acid reactive substances (TBARS), mitochondrial swelling, and activities of scavenging superoxide anions in vitro. D-galactose (100 mg/kg/day) was injected subcutaneously into back of the neck of mice for 7 weeks to induce an aging model. The effects of CMP on the activities of catalase (CAT), surperoxide dismutase (SOD), glutathione peroxidase (GPx) and anti-hydroxyl radicals were assayed in vivo using commercial monitoring kits. The results showed tha... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4156749 Fri, 12 Nov 2010 07:00:03 +0100 4156749 http://www.medworm.com/index.php?rid=4156747&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21061464%26dopt%3DAbstract Authors: Jiang S, Zhang Y, Zu Y, Wang Z, Fu Y Water decoctions from the leaves of Taxus cuspidata are used in traditional Chinese medicine to treat cancer, suggesting that water soluble constituents from these leaves may possess anticancer properties. Interestingly, hydrophilic paclitaxel derivatives, as opposed to paclitaxel itself, can be detected by high pressure liquid chromatography in water decoctions from these leaves. The remainder extracts, which are free of paclitaxel and hydrophilic paclitaxel derivatives, from the T. cuspidata leaves were investigated for antitumor activity in vivo and in vitro for the first time in this study. EE80B, 7-xylosyl-10-deacetylpaclitaxel and 7-xylosyl-10-deacetylpaclitaxel C displayed the most antitumor activity in vivo. However, in vitro studie... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4156747 Fri, 12 Nov 2010 07:00:03 +0100 4156747 http://www.medworm.com/index.php?rid=4156744&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21061465%26dopt%3DAbstract This study aims to evaluate the therapeutic benefits of matrine on primary and metastatic breast cancer. Matrine inhibited the viability of and induced apoptosis in human MCF-7 and mouse 4T1 breast cancer cells in a dose-dependent manner in vitro as shown by MTT assay, flow cytometry and laser scanning confocal microscopy. Administration of matrine inhibited the growth of primary tumors and their metastases to lungs and livers, in a dose-dependent manner, in a highly metastatic model of 4T1 breast cancer established in syngeneic Balb/c mice. Tumors from matrine-treated mice had a smaller proliferation index, shown by immunostaining with an anti-Ki-67 antibody, a greater apoptosis index, shown by TUNEL-staining, and a less microvessel density, shown by immunostaining with an anti-CD31 A ant... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4156744 Fri, 12 Nov 2010 07:00:03 +0100 4156744 http://www.medworm.com/index.php?rid=4156743&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21061466%26dopt%3DAbstract This report is the first to evaluate the complete mitochondria-dependent apoptotic pathway of ATO in uveal melanoma cells. These results can be used to improve the clinical effectiveness of ATO treatment for uveal melanoma. PMID: 21061466 [PubMed - in process] (Source: The American Journal of Chinese Medicine) The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4156743 Fri, 12 Nov 2010 07:00:03 +0100 4156743 http://www.medworm.com/index.php?rid=4156742&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21061467%26dopt%3DAbstract Authors: Ramadevi Mani S, Lakshmi BS Cell division and apoptosis are two crucial components of tumor biology and the importance of increased cell proliferation and reduced cell death have made them valid therapeutic targets. The plant kingdom is a relatively underexploited cache of novel drugs, and crude extracts of plants are known for their synergistic activity. The present study assessed the anti-proliferative activity of the medicinal plant Centrosema pubescens Benth. Centrosema pubescens dichloromethane extract (CPDE) inhibited the proliferation of HL-60 (promyelocytic acute leukaemia) cells with an IC(50) value of 5 μg/ml. Further studies also showed that CPDE induces growth arrest at the G1 phase and specifically down-regulates the expressions of cyclin E and CDK2 and up-regula... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4156742 Fri, 12 Nov 2010 07:00:03 +0100 4156742 http://www.medworm.com/index.php?rid=4156741&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21061468%26dopt%3DAbstract This study investigates the effects of beriberine on the expression of lectin-like ox-LDL receptor-1 (LOX-1), scavenger receptor A (SR-A), SR class B type I (SR-BI) and ATP-binding cassette transporter A1 (ABCA1) in human macrophage-derived foam cells induced by ox-LDL. Different concentrations of Berberine were co-cultured with THP-1 derived foam cells. The mRNA and protein expressions of LOX-1, SR-A, SR-BI and ABCA1 were determined by RT-PCR and Western blot analysis, respectively. Ox-LDL significantly increased the expression of LOX-1 and inhibited the expression of SR-BI in a dose- and time-dependent manner. Berberine significantly inhibited the effects of ox-LDL in a dose- and time-dependent manner. Moreover, ox-LDL significantly promoted ABCA1 expression. However, berberine had no ef... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4156741 Fri, 12 Nov 2010 07:00:03 +0100 4156741 http://www.medworm.com/index.php?rid=4156740&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21061469%26dopt%3DAbstract In conclusion, our work suggests that paeonol down-regulates H(2)O(2)-induced NF-κB activity, as well as NF-κB-associated APP expression. Furthermore, the gene expression profile accompanying the suppression of NF-κB by paeonol was identified. The new gene set that can be targeted by paeonol provided a potential use for this drug and a possible pharmacological mechanism for other phenolic compounds that protect against oxidative-related injury. PMID: 21061469 [PubMed - in process] (Source: The American Journal of Chinese Medicine) The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4156740 Fri, 12 Nov 2010 07:00:03 +0100 4156740 http://www.medworm.com/index.php?rid=4156739&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21061470%26dopt%3DAbstract In conclusion, WEC could improve the viability and the capabilities of detoxification and antioxidation in hepatocytes by increasing the GSH level and the activities of GSH-related enzymes. PMID: 21061470 [PubMed - in process] (Source: The American Journal of Chinese Medicine) The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4156739 Fri, 12 Nov 2010 07:00:03 +0100 4156739 http://www.medworm.com/index.php?rid=4156738&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21061471%26dopt%3DAbstract We examined the effect of hirsutenoxime on the Toll-like receptor 4-mediated activation of Akt and nuclear factor (NF)-κB in lipopolysaccharide-stimulated keratinocytes. Hirsutenoxime, a cell signaling Akt inhibitor, and Bay 11-7085, an inhibitor of NF-κB activation, attenuated the lipopolysaccharide-induced expression of Toll-like receptor 4, activation of NF-κB and Akt, and the production of chemokines and reactive oxygen/nitrogen species. Hirsutenoxime may reduce the Toll-like receptor 4 expression-mediated NF-κB activation, which is regulated by the Akt pathway in keratinocytes exposed to lipopolysaccharides. This effect may reduce the skin inflammatory response. PMID: 21061471 [PubMed - in process] (Source: The American Journal of Chinese Medicine) The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4156738 Fri, 12 Nov 2010 07:00:03 +0100 4156738 http://www.medworm.com/index.php?rid=4156737&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21061472%26dopt%3DAbstract In this study, a protease from a fermented culture broth of S. commune demonstrated strong fibrinolytic and fibrinogenolytic activities. This fibrinolytic protease showed a suppression effect in blood coagulation in co-incubation with rat citrated blood through thromboelastographic analysis. The protease suppressed aggregation of fibrin (ogen), but not the platelets, in clotting formation and significantly decreased the clot strength. We also found very little potency in this protease to activate plasminogen, thus it exhibits the potential for an ideal fibrinolytic candidate for therapeutic applications in the future. PMID: 21061472 [PubMed - in process] (Source: The American Journal of Chinese Medicine) The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4156737 Fri, 12 Nov 2010 07:00:03 +0100 4156737 http://www.medworm.com/index.php?rid=4156736&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21061473%26dopt%3DAbstract In this study, we observed that PD's antiproliferative effect was significantly enhanced by epicatechin (EC), a strong natural antioxidant in grape seed. Evidence for the synergistic antiproliferative effect was supported by the remarkable increase in the number of apoptotic cells. PMID: 21061473 [PubMed - in process] (Source: The American Journal of Chinese Medicine) The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=4156736 Fri, 12 Nov 2010 07:00:03 +0100 4156736 http://www.medworm.com/index.php?rid=3943554&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20821815%26dopt%3DAbstract The objective of this study was to assess the evidence for or against the effectiveness of moxibustion as a treatment option for pain. Fourteen electronic databases were searched. Randomized clinical trials (RCTs) testing moxibustion in human patients with pain of any type were considered. Trials using direct or indirect moxibustion were included. Studies comparing moxibustion with other treatments of unproven effectiveness, studies testing moxibustion together with other treatments of unproven efficacy and trials where pain was not a central symptom of the condition were all excluded. The selection of studies, data extraction, and validation were performed independently by two reviewers. Four RCTs met all the inclusion criteria. Others were of poor methodological quality. Two RCTs suggest... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=3943554 Wed, 08 Sep 2010 18:57:03 +0100 3943554 http://www.medworm.com/index.php?rid=3943553&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20821816%26dopt%3DAbstract Authors: Carpenter RJ, Dillard J, Zion AS, Gates GJ, Bartels MN, Downey JA, De Meersman RE Restoration of the sympathovagal (S/V) balance, involving a lowering of sympathetic and/or an augmentation of vagal modulation or a combination of both is associated with improvements in cardiovascular morbidity and mortality. To determine whether acupuncture exerts a favorable influence upon resting blood pressure and sympathovagal balance, a single-blind cross-over investigation was used to study the acute effects of acupuncture on S/V balance in normal healthy subjects. The ANOVA revealed a significant lowering of the sympathovagal balance (LF:HF) during rest for the acupuncture treatment from pre (4 +/- 2 nu) to post (2.2 +/- 1.8 nu)(p < 0.05). No such change was seen during sham treatment... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=3943553 Wed, 08 Sep 2010 18:57:03 +0100 3943553 http://www.medworm.com/index.php?rid=3943552&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20821817%26dopt%3DAbstract Authors: Sun MY, Hsieh CL, Cheng YY, Hung HC, Li TC, Yen SM, Huang IS Chronic neck myofascial pain syndrome (MPS) is a common disorder seen in clinics. There is no gold standard method to treat myofascial pain. We investigated the effects of acupuncture on patients with chronic neck MPS by a single-blind randomized controlled trial. A total of 35 patients were randomly allocated to an acupuncture group (AG) or a sham acupuncture group (SG). Each subject received acupuncture treatment twice per week for three consecutive weeks. The primary outcome measure was quality of life as assessed with Short Form-36, and secondary outcome measures were neck range of motion (ROM), motion-related pain, and Short-Form McGill Pain Questionnaire (SF-MPQ), as determined by a blinded investigator. The cl... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=3943552 Wed, 08 Sep 2010 18:57:03 +0100 3943552 http://www.medworm.com/index.php?rid=3943551&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20821818%26dopt%3DAbstract Authors: Hu WL, Chang CH, Hung YC A previous study has shown that laser acupuncture is a useful healing method for the treatment of visceral postmenopausal obesity in combination with a low-calorie diet. We observe and evaluate the therapeutic effect of laser acupuncture in subjects of simple obesity with a non-restrictive diet protocol. Subjects included 73 women and 22 men with simple obesity and body mass indices >/= 27 kg/m(2). Daily energy intake recommendations for obese females and males were 1620.0 and 1894.2 kcal in average, respectively. The gallium aluminum arsenide Handylaser Trion was used to apply 0.25 J of energy to each of the following acupuncture points three times per week for four consecutive weeks: Stomach, Hunger, ST25, ST28, ST40, SP15, and CV9. The subjects' ... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=3943551 Wed, 08 Sep 2010 18:57:03 +0100 3943551 http://www.medworm.com/index.php?rid=3943550&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20821819%26dopt%3DAbstract Authors: Moritaka K, Zeredo JL, Kimoto M, Nasution FH, Hirano T, Toda K A descending inhibitory mechanism from the periaqueductal gray (PAG) to the spinal cord through the nucleus raphe magnus (NRM) is strongly involved in endogenous analgesic system produced by acupuncture stimulation. In addition to the PAG to NRM system which descends in the medial pathway of the brain stem, the nucleus reticularis lateralis (NRL) situated in the lateral part of the brain stem is reported to play an important role in modulating centrifugal antinociceptive action. In the present study, to clarify the role of NRL in acupuncture analgesia, we investigated the response properties of NRL neurons to acupuncture stimulation. The majority of NRM-projecting NRL neurons were inhibited by electroacupuncture st... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=3943550 Wed, 08 Sep 2010 18:57:03 +0100 3943550 http://www.medworm.com/index.php?rid=3943549&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20821820%26dopt%3DAbstract Authors: Hsu CL, Hsu CC, Yen GC Freshwater clam is traditionally used as a food and has been mentioned in ancient books to have a hepatoprotective effect. The hepatoprotective effect of freshwater clam extract was evaluated in the model of chronic hepatic fibrosis induced by carbon tetrachloride (CCl(4)). Male Sprague-Dawley rats were orally treated with freshwater clam extract (0.3, 0.6 and 1.5 g/kg of bw) or silymarin (0.2 g/kg of bw) along with the administration of CCl(4) (0.5 ml/rat, 20% CCl(4) in olive oil) for eight consecutive weeks. Blood samples were collected for assaying serum biochemical parameters. The livers were excised for evaluating peroxidation products and antioxidant substances, as well as the activities of antioxidant enzymes. Pathological histology was also perfo... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=3943549 Wed, 08 Sep 2010 18:57:03 +0100 3943549 http://www.medworm.com/index.php?rid=3943548&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20821821%26dopt%3DAbstract This study examined the pharmacokinetic characteristics of laetispicine in plasma and brain distribution in rats by a simple sensitive HPLC-UV method. The separation was performed on a reverse-phase ODS column (250 mm x 4.6 mm, i.d., 5 mum) with a mobile phase composed of acetonitrile-water (75:25, v/v) as the mobile phase at a flow rate of 1.0 ml/min with UV detection at 259 nm. The calibration curve of laetispicine in rat plasma showed excellent linear behavior between 0.005-5.0 mug/ml (r(2) = 0.9992), and between 0.02-0.5 mug/ml (r(2) = 0.9952) in rat brain samples. The lower limit of quantification (LLOQ) was found to be 0.005 mug/ml in rat plasma and 0.02 mug/ml in rat brain samples. This HPLC assay was a precise and reliable method for the analysis of laetispicine in pharmacokinetic ... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=3943548 Wed, 08 Sep 2010 18:57:03 +0100 3943548 http://www.medworm.com/index.php?rid=3943547&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20821822%26dopt%3DAbstract In conclusion, PMBE treatment prevents H(2)O(2) and CCl(4)-induced liver damage, and therefore could have a potential clinical usage. PMID: 20821822 [PubMed - as supplied by publisher] (Source: The American Journal of Chinese Medicine) The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=3943547 Wed, 08 Sep 2010 18:57:03 +0100 3943547 http://www.medworm.com/index.php?rid=3943546&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20821823%26dopt%3DAbstract Authors: Kim SJ, Park JH, Kim KH, Lee WR, Chang YC, Park KK, Lee KG, Han SM, Yeo JH, Pak SC Bee venom (BV) has a long tradition of use for the control of pain and inflammation in various chronic diseases. Carbon tetrachloride (CCl(4)) is known to induce hepatotoxicity after being metabolized to the highly reactive trichloromethyl free radical and its peroxy radical. The purpose of the current study was to examine whether BV regulates the pro-inflammation and fibrosis related genes against a mouse model of hepatic fibrosis induced by CCl(4) and ethanol-treated hepatocytes (ETH). Test mice were administered with CCl(4) (2 ml/mg) and hepatocytes were treated with 25 mM ethanol. BV was added to the final concentration of 0.05-0.5 mg/kg and 1-100 ng/ml for in vivo and in vitro testing, resp... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=3943546 Wed, 08 Sep 2010 18:57:03 +0100 3943546 http://www.medworm.com/index.php?rid=3943545&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20821824%26dopt%3DAbstract In this study, antioxidative and antiviral properties of flowering cherry cultivars (Prunus yedoensis, Prunus sargentii, Prunus lannesiana, and Prunus cerasus) in Korea were investigated. The antioxidant property was assayed for specific activities including 2,2-diphenyl-1-picrylhydrazyl (DPPH) hydroxy radical scavenging activity, reducing power capacity, and superoxide dismutase (SOD) like activity. In addition, antiviral activity was determined by inhibition studies on the infection cycle of porcine epidemic diarrhea virus (PEDV), measured as minimum concentration of cherry extracts that inhibited 50% of cytopathic effect (CPE) on PEDV. Our results show that the four varieties of cherries contain substantially high antioxidants and antiviral activities. In particular, P. cerasus contains... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=3943545 Wed, 08 Sep 2010 18:57:03 +0100 3943545 http://www.medworm.com/index.php?rid=3943544&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20821825%26dopt%3DAbstract In this study, the possible use of wild Panax ginseng (WPG) for enhancement of host immunity in chemotherapy was investigated. In the cell proliferation assay, WPG significantly enhanced the proliferation of RAW 264.7 macrophages and protected against cell regression in macrophages treated with methotrexate (MTX). WPG induced the production of nitric oxide and the expression of inducible nitric oxide synthase and cyclooxygense-2 mRNA. Furthermore, WPG enhanced the production of cytokines including interleukin (IL)-1alpha, IL-1beta, IL-6, tumor necrosis factor-alpha and granulocyte-macrophage colony-stimulating factor, and chemokines such as macrophage chemotactic protein-1 and regulated upon activation, normal T-cell expressed and secreted (RANTES), regardless of MTX co-administration. Tak... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=3943544 Wed, 08 Sep 2010 18:57:03 +0100 3943544 http://www.medworm.com/index.php?rid=3943543&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20821826%26dopt%3DAbstract In this study, we investigate the effect of C.CS-4 on human monocyte-derived dendritic cells (Mo-DCs), which are generated from PBMCs by the treatment with GM-CSF and IL-4. It is observed that Mo-DCs pretreated with C.CS-4 show an immature phenotype. Moreover, C.CS-4 significantly inhibits proliferation of CD4+ T cells, attenuates the production of cytokines in Mo-DCs and balances the Th1 and Th2 response in immune system. Our findings indicate that C.CS-4 exerts the immunosuppressive effect through inhibiting the CD4+ T cells proliferation, regulating cytokine secretions of Th1 and Th2 response (Mo-DCs) and inducing phenotypic immature of Mo-DCs which may be related to the antigen presenting dysfunction. PMID: 20821826 [PubMed - as supplied by publisher] (Source: The American Journal ... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=3943543 Wed, 08 Sep 2010 18:57:03 +0100 3943543 http://www.medworm.com/index.php?rid=3943542&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20821827%26dopt%3DAbstract Authors: Chae HS, Kang OH, Choi JG, Oh YC, Lee YS, Brice OO, Chong MS, Lee KN, Shin DW, Kwon DY To determine the anti-inflammatory and analgesic activities of methyl gallate (MG) isolated from Galla Rhois, MG was studied in vivo for its analgesic activities using the writhing response in mice. Anti-inflammatory activity of MG was evaluated for NO and IL-6 production in RAW 264.7 cells. MG inhibited LPS-induced NO and IL-6 production. Consistent with these observations, the protein and mRNA expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) were inhibited by MG. Moreover, MG suppressed the phosphorylation of ERK1/2 in LPS-induced RAW 264.7 cells in a dose-dependent manner. Taken together, the results of this study indicate that MG has anti-inflammatory ef... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=3943542 Wed, 08 Sep 2010 18:57:03 +0100 3943542 http://www.medworm.com/index.php?rid=3943541&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20821828%26dopt%3DAbstract In this study, we examined the effects of Eriobotryae folium extract (EFE) on lipopolysaccharide (LPS)-induced production of nitric oxide (NO) and prostaglandin E(2)(PGE(2)) in RAW264 murine macrophage cells. EFE suppressed LPS-induced NO and PGE(2) production in a dose-dependent manner. Consistent with these observations, EFE reduced the LPS-induced expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) at both protein and mRNA levels. Furthermore, EFE significantly inhibited LPS-induced NF-kappaB binding activity, which was associated with the inhibition of IkappaB-alpha degradation. EFE also attenuated LPS-induced phosphorylation of mitogen-activated protein kinases (MAPKs) including extracellular signal-regulated kinase (ERK), p38 MAPK and c-Jun N-terminal k... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=3943541 Wed, 08 Sep 2010 18:57:03 +0100 3943541 http://www.medworm.com/index.php?rid=3943540&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20821829%26dopt%3DAbstract Authors: Yin Y, Yang M, Wang Y, Liu X, Wu W, Guan S, Guo DA, Cui Y, Jiang B Tanshinone IIA (TSNIIA) is the major active component of Salvia miltorrhiza, which is used in treatment of cardiovascular and cerebrovascular diseases traditionally in China. However, the low bioavailability of TSNIIA limits its clinical usage. To reveal the mechanism relating the absorption of TSNIIA, we detected the expression of efflux transporters in Caco-2 cells under the stimulation of TSNIIA. TSNIIA was purified and above 98% purity was confirmed by high-performance liquid chromatography. The expression of nine efflux transporters including BCRP, hPepT1, MCT and MRP1-6 in Caco-2 were verified by reverse transcription polymerase chain reaction, and the up-regulation of TSNIIA on the expression of these tr... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=3943540 Wed, 08 Sep 2010 18:57:03 +0100 3943540 http://www.medworm.com/index.php?rid=3943539&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20821830%26dopt%3DAbstract Authors: Lau KM, Fu LH, Cheng L, Wong CW, Wong YL, Lau CP, Han SQ, Chan PK, Fung KP, Lau CB, Hui M, Leung PC Fructus Psoraleae and Folium Eucalypti Globuli have long been used as Chinese medicines to treat various ailments such as asthma, eczema and dermatomycosis. In previous studies, their antifungal activities were demonstrated. The aim of the present study was to isolate active antidermatophytic compounds from their ethanolic extracts by means of bioassay-guided purification. Guided by the inhibitory activities on Trichophyton mentagrophytes, Trichophyton rubrum and Paecilomyces variotii, bakuchiol was isolated from the n-hexane fraction of Fructus Psoraleae whilst macrocarpal C was isolated from the n-hexane fraction of Folium Eucalypti Globuli. Both pure compounds could effective... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=3943539 Wed, 08 Sep 2010 18:57:03 +0100 3943539 http://www.medworm.com/index.php?rid=3751218&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20626050%26dopt%3DAbstract Authors: Zheng H, Chen M, Wu X, Li Y, Liang FR The aim of this article is to present a standardized protocol of acupuncture for the management of migraine. A systematic review of available randomized controlled trials of acupuncture for migraineurs was conducted in the five following electronic databases: Cochrane Central Register of Controlled trials, MEDLINE, EMBASE, PsycINFO and CINAHL. Information of selected acupoints and treatment course was extracted from the included trials. Then we analyzed the treatment methods used in these trials, to identify any similarities of therapeutic approaches. Additionally, quality of all the included trials was assessed. At last, the extracted information of acupuncture protocols was analyzed, and the similarities of therapeutic approaches were su... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=3751218 Thu, 15 Jul 2010 03:00:06 +0100 3751218 http://www.medworm.com/index.php?rid=3751217&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20626051%26dopt%3DAbstract This study observes changes in symptoms of xerophthalmia pre- and post-acupuncture therapy and compares the results of the acupuncture therapy (AT) group and the artificial tear control (ATC) group. Parallel comparative studies were carried out on 44 patients with xerophthalmia, who were divided into the AT group (n = 20) and the ATC group (n = 24). A 10-session acupuncture therapy program was performed for the AT group while Dextran 70 was used for the ATC group with each course of treatment lasting 21 day. Examinations were made on the day when a patient was chosen to join the study, 1 hour after completion of treatment, and 3 weeks after stopping treatment. There was no statistically significant difference in terms of the reduction of the symptoms and sign score (SSS) 1 hour after compl... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=3751217 Thu, 15 Jul 2010 03:00:06 +0100 3751217 http://www.medworm.com/index.php?rid=3751216&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20626052%26dopt%3DAbstract This study supports the belief that the acupoint herbal patch is an effective treatment for allergic rhinitis and can significantly improve general health, social life and vitality in quality of life. PMID: 20626052 [PubMed - in process] (Source: The American Journal of Chinese Medicine) The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=3751216 Thu, 15 Jul 2010 03:00:06 +0100 3751216 http://www.medworm.com/index.php?rid=3751215&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20626053%26dopt%3DAbstract In conclusion, the current study shows that auricular acupressure employing Japanese Magnetic Pearls or vaccaria seeds can decrease BMI, with the vaccaria seed method showing the greatest reduction. Auricular acupressure did not result in decreased TC, TG, HDL, or LDL in the current eight-week protocol. PMID: 20626053 [PubMed - in process] (Source: The American Journal of Chinese Medicine) The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=3751215 Thu, 15 Jul 2010 03:00:06 +0100 3751215 http://www.medworm.com/index.php?rid=3751214&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20626054%26dopt%3DAbstract This study evaluates the effects of electrical stimulation on body composition and the meridian system in postmenopausal women with obesity. Forty-one postmenopausal women were recruited in Taiwan. The body composition was used as a screening test for obesity (percentage of body fat: > 30%, waist circumference: > 80 cm). The experimental group (EG, n = 20) received modulated middle-frequency electrical stimulation treatment for 20 min twice a week for 12 consecutive weeks at the Zusanli (ST36) and Sanyinjiao (SP6) acupoints. The control group (CG, n = 21) did not receive any intervention. The measurements of body composition and the meridian system were recorded for both groups in the pre- and post-study. The results showed that the data of body composition (weight, waist and hip cir... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=3751214 Thu, 15 Jul 2010 03:00:06 +0100 3751214 http://www.medworm.com/index.php?rid=3751213&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20626055%26dopt%3DAbstract Authors: Vincent A, Hill J, Kruk KM, Cha SS, Bauer BA External qigong as a pharmacotherapy adjunct was investigated in 50 subjects with chronic pain (pain lasting > 3 months with pain score of >/= 3 on 0-10 numeric analog scale) who presented to a qigong healing center. Participants were randomized to receive either external qigong treatment (EQT) or equivalent attention time (EAT) in weekly 30-min sessions for four consecutive weeks. Outcomes were assessed before and after sessions. The primary outcome measure was intensity of pain by a 10-cm visual analog scale used to rate all pain severity measurements. At 8-week follow-up, participants were contacted by telephone and mailed a questionnaire. Most had experienced pain for > 5 years (66%); the rest, for > 3 to 5 years (8%... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=3751213 Thu, 15 Jul 2010 03:00:06 +0100 3751213 http://www.medworm.com/index.php?rid=3751212&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20626056%26dopt%3DAbstract Authors: Kano T, Shimizu M, Kanda T, Hijikata Y Alloimmune recurrent spontaneous abortion (RSA) cases that could not be treated with lymphocyte transfusion due to medical and social reasons were treated with Sairei-to therapy as an emergency measure and all four cases resulted in live births. This may show that Sairei-to treatment is effective in preventing alloimmune RSA. The efficacy of Sojyutsu-Sairei-to and Byakujyutsu-Sairei-to on autoimmune RSA has already been proven. When they were used in the treatment of alloimmune-, autoimmune complicated RSA, the abortion prevention rates were 65.4% and 82.3% respectively. These results indicate that Sairei-to is effective in the treatment of alloimmune RSA and alloimmune-, autoimmune complicated RSA. PMID: 20626056 [PubMed - in process... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=3751212 Thu, 15 Jul 2010 03:00:06 +0100 3751212 http://www.medworm.com/index.php?rid=3751211&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20626057%26dopt%3DAbstract This study was initiated to determine the possible antidiabetic effects of total flavonoids of Litsea Coreana leve (TFLC), an alcohol extract from the dried leaves of Litsea Coreana leve, on type 2 diabetic rats. Male Sprague-Dawley rats (n = 40, 160-180 g) were divided into two groups and fed with normal chow diet (Normal Control group) or high-fat diet (HFD) for a period of 4 weeks. After 4 weeks of dietary manipulation, the HFD-fed rats were injected with 30 mg/kg streptozocin (STZ) to induce diabetes 72 hours after STZ injection. These diabetic rats were randomly divided into 3 groups (n = 10): Diabetic Control group, Diabetic + TFLC group and Diabetic + PIO group. Diabetic + TFLC group and Diabetic + PIO group were orally administered with 400 mg/kg TFLC or 10 mg/kg pioglitazone (all ... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=3751211 Thu, 15 Jul 2010 03:00:06 +0100 3751211 http://www.medworm.com/index.php?rid=3751210&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20626058%26dopt%3DAbstract Authors: Koh PO EGb 761 is an extract of Gingko biloba that exhibits neuroprotective effects against cerebral ischemia. The mammalian target of rapamycin (mTOR) is a critical downstream effector of Akt and a central regulator of ribosomal biogenesis and protein synthesis. We investigated whether EGb 761 regulates Akt downstream targets, including mTOR, p70S6 kinase, and S6 phosphorylation. Adult male rats were treated with vehicle or EGb 761 (100 mg/kg) prior to middle cerebral artery occlusion (MCAO). Brains were collected at 24 hours after MCAO and the cerebral cortex regions were examined. We previously showed that EGb 761 significantly reduces infarct volume and decreases the number of TUNEL-positive cells in the cerebral cortex. Ischemic brain injury induces a decrease in Akt up-s... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=3751210 Thu, 15 Jul 2010 03:00:06 +0100 3751210 http://www.medworm.com/index.php?rid=3751209&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20626059%26dopt%3DAbstract Authors: Fang WK, Weng YJ, Chang MH, Lin CC, Chen YS, Hsu HH, Tsai FJ, Tsai CH, Kuo WH, Lu CY, Huang CY The aim of the study was to evaluate the proliferative effects of chishao on neuron regeneration. A silicone rubber nerve guide across a 15-mm gap was filled with different concentrations of chishao (0-125 mg/ml) in the dissected sciatic nerve of the right leg in SD rats. The left legs were used as control. After eight weeks, the regenerated nerves showed dose-dependently activated fibroblast growth factor-2 (FGF-2) signaling with increased urokinase plasminogen activator (uPA), decreased plasminogen activator inhibitor-1 (PAI-1) and enhanced proliferative proteins, extracellular signal regulated kinase (ERK)- and c-Jun N-terminal kinase (JNK)-signalings. The results imply that apply... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=3751209 Thu, 15 Jul 2010 03:00:06 +0100 3751209 http://www.medworm.com/index.php?rid=3751208&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20626060%26dopt%3DAbstract In conclusion, the under expressions of MIF and cyclophilin A in the frontal cortex and hippocampus in KA-treated rats, which were overcome by both UR and UH treatment, suggesting that both MIF and cyclophilin A at least partly participate in the anticonvulsive effect of UR. PMID: 20626060 [PubMed - in process] (Source: The American Journal of Chinese Medicine) The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=3751208 Thu, 15 Jul 2010 03:00:06 +0100 3751208 http://www.medworm.com/index.php?rid=3751207&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20626061%26dopt%3DAbstract This study aims to investigate the hepatoprotective activity and active constituents of the ethanol extract of Scoparia dulcis (SDE). The hepatoprotective effect of SDE (0.1, 0.5 and 1 g/kg) was evaluated on the carbon tetrachloride (CCl(4))-induced acute liver injury. The active constituents were detected by high performance liquid chromatography (HPLC). Mice pretreated orally with SDE (0.5 and 1.0 g/kg) and silymarin (200 mg/kg) for five consecutive days before the administering of a single dose of 0.2% CCl(4) (10 ml/kg of bw, ip) showed a significant inhibition of the increase of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Histological analyses also showed that SDE (0.5 and 1.0 g/kg) and silymarin reduced the extent of liver lesions induced by CCl(4), incl... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=3751207 Thu, 15 Jul 2010 03:00:06 +0100 3751207 http://www.medworm.com/index.php?rid=3751206&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20626062%26dopt%3DAbstract Authors: Su S, Hua Y, Duan JA, Zhou W, Shang E, Tang Y Shaofu Zhuyu decoction is a famous formula for treating primary dysmenorrhea in China since the Qing dynasty. In this paper, the inhibitory effects of active-guided fraction and its main bioactive components of Shaofu Zhuyu decoction on a model of non-pregnant mice uterine contraction induced by oxytocin in vitro were investigated. Qualitative and quantitative chemical analyses were used to correlate the chemical composition of active fraction with the spasmolytic effects. Seven ingredients in the active fraction were identified and quantified by HPLC-DAD. Three ingredients, ferulic acid, vanillic acid, and typhaneoside, were evaluated for their effects on mice isolated uterine contraction induced by oxytocin in vitro. The ED(50) o... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=3751206 Thu, 15 Jul 2010 03:00:06 +0100 3751206 http://www.medworm.com/index.php?rid=3751205&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20626063%26dopt%3DAbstract In conclusion, we established that the mRNA expression level of TRPV1 and its calcium-mediating function in naive DRG neurons could be down-regulated by emodin through perhaps the non-TRPV1 channel pathways, and this might be the molecular mechanisms for rhubarb to inhibit hyperalgesia induced by inflammatory stimuli. PMID: 20626063 [PubMed - in process] (Source: The American Journal of Chinese Medicine) The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=3751205 Thu, 15 Jul 2010 03:00:06 +0100 3751205 http://www.medworm.com/index.php?rid=3751204&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20626064%26dopt%3DAbstract In this study, we report the extract of Tripterygium wilfordii Hook F with a novel extraction method significantly protected dopaminergic neurons from LPS-induced degeneration in rat mesencephalic neuron-glia cultures. Cells pretreated with the extract have shown dose-dependent inhibition of LPS-induced TNFalpha and excessive NO production. More importantly, the total number of activated microglia was greatly reduced in these pretreated cells. Our results suggest that the extract of Tripterygium wilfordii Hook F has a strong bioactive function to diminish the pro-inflammatory factors, such as TNFalpha and NO. These data might also shed light for future neurodegenerative disease therapy. PMID: 20626064 [PubMed - in process] (Source: The American Journal of Chinese Medicine) The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=3751204 Thu, 15 Jul 2010 03:00:06 +0100 3751204 http://www.medworm.com/index.php?rid=3751202&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20626065%26dopt%3DAbstract In this study, the anti-oxidant capacities of Huangqin extracts (water, ethanol and ether extracts) were evaluated and compared to commonly used CMD herbs, Heshouwu, roots of Polygonum multiflorum Thunb (Polygonaceae) and Renshen (or Ginseng), roots of Panax ginseng CA Meyer (Araliaceae). The anti-oxidant capacities were measured by using both cell-free assay [ferric reducing/anti-oxidant power (FRAP)] and biological methods [2,2'-azobis-(2-amidinopropane) (AAPH)-induced haemolysis assay and H(2)O(2)-induced cell damage on H9C2 cells]. Additionally, the total phenolic content was measured using Folin-Ciocalteu methods. Water extract of Huangqin has the highest anti-oxidant activities compared to the ethanol and ether extracts. A positive relationship between the anti-oxidant effects and to... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=3751202 Thu, 15 Jul 2010 03:00:06 +0100 3751202 http://www.medworm.com/index.php?rid=3600469&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20503462%26dopt%3DAbstract This study aimed to evaluate the effect of ear acupressure for visual improvement on school children in Taiwan. Participants were fifth-grade school children with visual acuity between 6/37.5 and 6/9.6 in one eye. The experimental group (n = 35) received a 15-week ear acupressure intervention with seed embedding; the control group (n = 35) did not. Data for demographic factors, visual acuity, refractive error, and behavior toward visual health were collected before and after the intervention. The significant differences were observed between the two groups in visual acuity (p = 0.02), refractive error (p = 0.04), and behaviors toward visual health (p = 0.045). Performing ear acupressure may facilitate improved visual health for children. However, it requires more extended studies exploring... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=3600469 Thu, 27 May 2010 12:03:03 +0100 3600469 http://www.medworm.com/index.php?rid=3600468&cid=s_33196_8_f&fid=33196&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20503463%26dopt%3DAbstract Authors: Jan YM, Li TC, Hsieh CL Our previous studies found that segmental effect of spinal nerve plays an important role in acupuncture stimulation (AS) on nail-fold microcirculation. Calcitonin-gene related peptide (CGRP) is a potent endogenous vasodilator. Therefore, the aim of the present study was to investigate the effect of AS on skin blood flow (SBF) and skin temperature (ST), and the involvement of spinal nerve segment and CGRP. A total of 17 healthy adult volunteers were studied, and all of them accepted three assessments as follows: (1) left Waiguan (SJ5) assessment (LW), AS applied to Waiguan acupoint of the left hand with obtaining qi; (2) right Waiguan assessment (RW), AS applied to Waiguan acupoint of the right hand with obtaining qi; (3) sham assessment, AS applied to t... The American Journal of Chinese Medicine journals http://www.medworm.com/rss/comments.php?id=3600468 Thu, 27 May 2010 12:03:03 +0100 3600468