MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'The American Journal of Geriatric Pharmacotherapy' source. Sun, 21 Mar 2010 15:09:53 +0100 http://www.medworm.com/index.php?rid=3375008&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20226389%26dopt%3DAbstract Authors: Hanlon JT PMID: 20226389 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=3375008 Mon, 01 Feb 2010 00:00:00 +0100 3375008 http://www.medworm.com/index.php?rid=3375007&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20226390%26dopt%3DAbstract Conclusions: Vitamin D insufficiency appears to be highly prevalent among older adults. Evidence from epidemiologic studies and small clinical trials suggests an association between 25(OH)D concentrations and systolic blood pressure, risk for CV disease-related deaths, symptoms of depression, cognitive deficits, and mortality. The Women's Health Initiative Randomized Trial did not find a benefit of vitamin D supplementation on blood pressure, myocardial infarction, or mortality in postmenopausal women. PMID: 20226390 [PubMed - as supplied by publisher] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=3375007 Mon, 01 Feb 2010 00:00:00 +0100 3375007 http://www.medworm.com/index.php?rid=3375006&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20226391%26dopt%3DAbstract Conclusions: Observational studies suggest an association between use of anticonvulsant medications, reduced bone mineral density, and increased fracture risk. Randomized clinical trials are needed to guide the management of bone disease among those who use anticonvulsants. PMID: 20226391 [PubMed - as supplied by publisher] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=3375006 Mon, 01 Feb 2010 00:00:00 +0100 3375006 http://www.medworm.com/index.php?rid=3375005&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20226392%26dopt%3DAbstract Conclusion: Adherence to established guidelines, along with customization of antimicrobial therapy based on local rates and patterns of resistance and patient-specific risk factors, likely will improve the treatment outcome of elderly patients with CAP. PMID: 20226392 [PubMed - as supplied by publisher] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=3375005 Mon, 01 Feb 2010 00:00:00 +0100 3375005 http://www.medworm.com/index.php?rid=3375004&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20226393%26dopt%3DAbstract Conclusions: Despite awareness of polypharmacy and its potential consequences in older patients, results of our analysis suggest that polypharmacy remains widespread in US nursing homes. Although complex medication regimens are often necessary for nursing home residents, monitoring polypharmacy and its consequences may improve the quality of nursing home care and reduce unnecessary health care spending related to adverse events. PMID: 20226393 [PubMed - as supplied by publisher] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=3375004 Mon, 01 Feb 2010 00:00:00 +0100 3375004 http://www.medworm.com/index.php?rid=3375003&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20226394%26dopt%3DAbstract Conclusions: No previous cases of ranolazine-related DOE requiring drug cessation have been published. Ranolazine may be associated with DOE in this elderly man. PMID: 20226394 [PubMed - as supplied by publisher] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=3375003 Mon, 01 Feb 2010 00:00:00 +0100 3375003 http://www.medworm.com/index.php?rid=3375002&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20226395%26dopt%3DAbstract Conclusion: Data from these recently published studies could be used to guide the development and evaluation of quality improvement, research, or clinical practice initiatives. PMID: 20226395 [PubMed - as supplied by publisher] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=3375002 Mon, 01 Feb 2010 00:00:00 +0100 3375002 http://www.medworm.com/index.php?rid=3247410&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20129253%26dopt%3DAbstract Conclusions: Evidence indicates that the osteoporosis treatments currently available in the United States are beneficial for treating osteoporosis in geriatric patients. However, data are limited for the oldest patients (>/=80 years) and those with significant comorbidities. Because of the limited availability of data for geriatric patients with significant comorbidities, the properties of the various agents, including efficacy, tolerability, and potential contraindications, should be considered carefully for each geriatric patient. PMID: 20129253 [PubMed - as supplied by publisher] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=3247410 Tue, 01 Dec 2009 00:00:00 +0100 3247410 http://www.medworm.com/index.php?rid=3247409&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20129254%26dopt%3DAbstract Conclusions: Overall, there is a scarcity of data regarding the use of pharmacologic agents in older adults with T2DM, and clinical guidance is largely based on data obtained from younger populations. The selection of appropriate drug regimens for these patients remains challenging. PMID: 20129254 [PubMed - as supplied by publisher] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=3247409 Tue, 01 Dec 2009 00:00:00 +0100 3247409 http://www.medworm.com/index.php?rid=3247408&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20129255%26dopt%3DAbstract Conclusions: The definitive survival advantage of irinotecan observed in clinical trials was not reproducible in this population of elderly Medicare patients. The results emphasize the need for expansion of trials to include a more diverse patient group as well as continued evaluation of more recent chemotherapies in real-world settings. PMID: 20129255 [PubMed - as supplied by publisher] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=3247408 Tue, 01 Dec 2009 00:00:00 +0100 3247408 http://www.medworm.com/index.php?rid=3247407&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20129256%26dopt%3DAbstract Conclusions: The prevalence of transdermal fentanyl use was higher than that of morphine, oxycodone, and hydromorphone among people aged >/=80 years residing in noninstitutional settings in Finland. The variation in use between hospital districts suggests that organizational culture may have a strong impact on prescribing practices. Our data highlight the need for further education regarding the appropriate use of opioids among older people. PMID: 20129256 [PubMed - as supplied by publisher] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=3247407 Tue, 01 Dec 2009 00:00:00 +0100 3247407 http://www.medworm.com/index.php?rid=3247406&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20129257%26dopt%3DAbstract Conclusions: This pilot study tested the feasibility of a medication management program designed to improve the quality of medication use in older adults with underlying psychiatric disease. Findings from this study, which will be reported at a later date, will help to refine the program and subsequent testing, with the overall goal of improving the quality of medication use and health outcomes in older adults. PMID: 20129257 [PubMed - as supplied by publisher] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=3247406 Tue, 01 Dec 2009 00:00:00 +0100 3247406 http://www.medworm.com/index.php?rid=3247405&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20129258%26dopt%3DAbstract Conclusions: Overall, solifenacin was found to improve symptom bother, HRQoL, work productivity, activity participation, and reduced medical care resource utilization in these elderly subjects with OAB who continued to have urgency symptoms with tolterodine and were willing to try solifenacin. This was an exploratory subgroup analysis of an open-label, noncomparative study; further research is needed to confirm these results. PMID: 20129258 [PubMed - as supplied by publisher] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=3247405 Tue, 01 Dec 2009 00:00:00 +0100 3247405 http://www.medworm.com/index.php?rid=3247404&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20129259%26dopt%3DAbstract Conclusion: Based on these findings, a substantial proportion of those Ontarians aged >/=60 years reported NHP use, and there is a need for greater communication with physicians to avoid potential drug-NHP interactions. PMID: 20129259 [PubMed - as supplied by publisher] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=3247404 Tue, 01 Dec 2009 00:00:00 +0100 3247404 http://www.medworm.com/index.php?rid=3052921&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19948300%26dopt%3DAbstract Conclusions: HF therapy that has published mortality and morbidity benefits in nonelderly patient populations has been associated with benefits in elderly patients. Elderly patients may have variable pharmacologic responses to these agents and may be susceptible to adverse events and drug-drug interactions due to concurrent treatments for comorbidities. Close monitoring of elderly patients undergoing HF treatment is essential to ensure optimal outcomes. PMID: 19948300 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=3052921 Thu, 01 Oct 2009 00:00:00 +0100 3052921 http://www.medworm.com/index.php?rid=3052920&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19948301%26dopt%3DAbstract Conclusions: Antihypertensive medications-particularly ACE inhibitors and diuretics-may be helpful in reducing the risk for and progression of dementia. Large randomized clinical trials are warranted to further explore the relationship between antihypertensive drugs and dementia. PMID: 19948301 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=3052920 Thu, 01 Oct 2009 00:00:00 +0100 3052920 http://www.medworm.com/index.php?rid=3052919&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19948302%26dopt%3DAbstract Conclusion: This study found that the utilization of health care resources and economic burden of LTC residents with COPD were primarily due to LTC, pharmacy, and inpatient costs. PMID: 19948302 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=3052919 Thu, 01 Oct 2009 00:00:00 +0100 3052919 http://www.medworm.com/index.php?rid=3052918&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19948303%26dopt%3DAbstract Conclusions: Medication underuse was relatively common in this study. Patients with greater comorbidity, but not polypharmacy, had increased odds of undertreatment. PMID: 19948303 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=3052918 Thu, 01 Oct 2009 00:00:00 +0100 3052918 http://www.medworm.com/index.php?rid=3052917&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19948304%26dopt%3DAbstract Conclusions: Levetiracetam was a probable cause of depression in these 2 elderly patients. Cautious use and additional monitoring may be necessary when prescribing levetiracetam to elderly patients, especially when prescribing to those with a history of renal impairment. PMID: 19948304 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=3052917 Thu, 01 Oct 2009 00:00:00 +0100 3052917 http://www.medworm.com/index.php?rid=2818181&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19766951%26dopt%3DAbstract Conclusions: In this decision analysis, genotype-guided warfarin therapy for anticoagulation in elderly patients with AF was potentially cost-effective, and its benefits were closely related to efficacy in preventing bleeding events. Clinical trials testing the efficacy of genotype-guided warfarin therapy are warranted. PMID: 19766951 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=2818181 Fri, 31 Jul 2009 23:00:00 +0100 2818181 http://www.medworm.com/index.php?rid=2818180&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19766952%26dopt%3DAbstract Conclusions: Based on the findings of this study, the benefits of treating elderly patients with hypertension in clinical practice may be lower than those reported by HYVET. The study results support the current recommendation that all patients with hypertension should be treated with >1 antihypertensive medication if adequate control is not achieved at low doses of a single medication. PMID: 19766952 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=2818180 Fri, 31 Jul 2009 23:00:00 +0100 2818180 http://www.medworm.com/index.php?rid=2818179&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19766953%26dopt%3DAbstract Conclusions: There was preferential prescribing of SSRI antidepressants among these older aged care home residents with depression. Cognitive impairment alone was not significantly associated with antidepressant prescribing; however, these aged care home residents with dementia and mood disorders had an increased likelihood of being treated with antidepressants. The prescribing of TCAs was significantly associated with concurrent benzodiazepine use. PMID: 19766953 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=2818179 Fri, 31 Jul 2009 23:00:00 +0100 2818179 http://www.medworm.com/index.php?rid=2818178&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19766954%26dopt%3DAbstract Conclusion: This article reports a case of chorea in an elderly patient who was receiving gabapentin for the treatment of anxiety. After gabapentin discontinuation, the chorea resolved completely, indicating a probable adverse drug reaction. PMID: 19766954 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=2818178 Fri, 31 Jul 2009 23:00:00 +0100 2818178 http://www.medworm.com/index.php?rid=2818163&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19766955%26dopt%3DAbstract Authors: Guay DR PMID: 19766955 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=2818163 Fri, 31 Jul 2009 23:00:00 +0100 2818163 http://www.medworm.com/index.php?rid=2622717&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19616182%26dopt%3DAbstract Conclusions: Antipsychotic use increased in US nursing homes from 1996 through 2006 and was associated with certain organizational characteristics and market characteristics. Future interventions to reduce antipsychotic use in nursing homes will have to focus on these factors. PMID: 19616182 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=2622717 Sun, 31 May 2009 23:00:00 +0100 2622717 http://www.medworm.com/index.php?rid=2622716&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19616183%26dopt%3DAbstract Conclusions: We found that polypharmacy was common in older cancer patients and increased during hospitali-zation. We also found that most OACE team recommendations communicated to physicians were implemented even though the primary physicians were not members of the OACE team. Future randomized trials are needed to assess the impact of the OACE team model of care on adverse events, survival, and cost in hospitalized older adult cancer patients. PMID: 19616183 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=2622716 Sun, 31 May 2009 23:00:00 +0100 2622716 http://www.medworm.com/index.php?rid=2622715&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19616184%26dopt%3DAbstract Conclusions: In this well-monitored geriatric population with chronic AF, including patients with falls and/or dementia, a high percentage were prescribed warfarin (85%), with low rates of stroke, hemorrhage, and death at 12 months despite a low TTR. Patients with falls and/or dementia had a high mortality rate (~45%). PMID: 19616184 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=2622715 Sun, 31 May 2009 23:00:00 +0100 2622715 http://www.medworm.com/index.php?rid=2622714&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19616185%26dopt%3DAbstract Conclusions: Despite disappointing results from recently completed Phase III trials of several novel compounds, the extent and breadth of activity at all phases of clinical development suggest that new pharmacotherapeutic options for the treatment of AD will become available within the next decade. PMID: 19616185 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=2622714 Sun, 31 May 2009 23:00:00 +0100 2622714 http://www.medworm.com/index.php?rid=2533374&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19447359%26dopt%3DAbstract CONCLUSION: In this small sample of VA patients with glaucoma, adherence to glaucoma medications could be improved, especially among those who reported difficulties using their medications and those who were nonwhite. PMID: 19447359 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=2533374 Tue, 31 Mar 2009 23:00:00 +0100 2533374 http://www.medworm.com/index.php?rid=2533373&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19447360%26dopt%3DAbstract CONCLUSION: Results of this retrospective analysis suggest that, compared with longer duration of CHEI therapy, discontinuation of CHEIs in these nursing home residents with dementia was associated with some adverse behavioral changes and decreased time spent engaging in leisure-related activities. PMID: 19447360 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=2533373 Tue, 31 Mar 2009 23:00:00 +0100 2533373 http://www.medworm.com/index.php?rid=2533372&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19447361%26dopt%3DAbstract CONCLUSIONS: In this analysis of data from elderly patients at 2 outpatient centers, a small set of 8 medications accounted for the majority of PIMs at both centers, irrespective of geographic and demographic variations. Female sex, polypharmacy, and number of primary care visits were significantly associated with PIM prescribing. In this analysis of data from elderly patients at 2 outpatient centers, a small set of 8 medications accounted for the majority of PIMs at both centers, irrespective of geographic and demographic variations. PMID: 19447361 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=2533372 Tue, 31 Mar 2009 23:00:00 +0100 2533372 http://www.medworm.com/index.php?rid=2533371&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19447362%26dopt%3DAbstract CONCLUSIONS: Geriatricians should assume that the medication lists supplied by GPs are incomplete or incorrect, and be aware that in approximately 25% of patients, symptoms may be caused by medication use inaccurately described in the referral. Reports by the community pharmacy may supply valuable additional information. Because there are also discrepancies between patients and pharmacies, medication use from a database-with data from prescribing physicians and pharmacy systems-will still have to be confirmed by the patient. PMID: 19447362 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=2533371 Tue, 31 Mar 2009 23:00:00 +0100 2533371 http://www.medworm.com/index.php?rid=2533370&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19447363%26dopt%3DAbstract CONCLUSIONS: In this survey, older adults trusted physicians and pharmacists more than the other sources studied to provide information on prescription drugs. Trust in physicians to provide price information was an important moderator of the effect of high drug spending on cost-related nonadhcrence. Efforts to provide patients and their providers with comparative data on drug prices and effectiveness may reduce cost-related nonadhcrence. PMID: 19447363 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=2533370 Tue, 31 Mar 2009 23:00:00 +0100 2533370 http://www.medworm.com/index.php?rid=2533369&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19447364%26dopt%3DAbstract CONCLUSIONS: Viewing of live health insurance presentations and adequate health literacy were associated with greater awareness of important pharmaceutical cost-assistance programs in this study in low-income, elderly individuals. The findings suggest that use of live presentations, in addition to health literacy materials and messages, may be important strategies in promoting knowledge of and enrollment in state and federal pharmaceutical cost-assistance programs for low-income seniors. PMID: 19447364 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=2533369 Tue, 31 Mar 2009 23:00:00 +0100 2533369 http://www.medworm.com/index.php?rid=2263566&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19281935%26dopt%3DAbstract Conclusions: A single dose of IV hydromorphone at 0.0075 mg/kg was neither clinically nor statistically different from IV morphine at 0.05 mg/kg for the treatment of acute, severe pain at 30 minutes postbaseline in these older adults in the ED. The incidence of adverse effects was not statistically different. Our data suggest that hydromorphone and morphine in the doses given had similar efficacy and safety profiles in these older adults. Neither regimen provided >/=50% pain relief for the majority of patients. Future investigations of acute pain management in older adults should examine the efficacy and safety of higher initial (loading) doses of opioids titrated at frequent intervals until adequate analgesia is achieved. PMID: 19281935 [PubMed - in process] (Source: The American J... The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=2263566 Sun, 01 Feb 2009 05:00:00 +0100 2263566 http://www.medworm.com/index.php?rid=2263562&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19281936%26dopt%3DAbstract Conclusions: The DAE RetroDUR was associated with a possible reduction in the use of potentially inappropriate prescription medications in these older adults. Further research, using a control population, is needed to show the impact on health care utilization and costs, adverse drug events, and health care and quality-of-life outcomes. PMID: 19281936 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=2263562 Sun, 01 Feb 2009 05:00:00 +0100 2263562 http://www.medworm.com/index.php?rid=2263558&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19281937%26dopt%3DAbstract Conclusions: The geriatric palliative care team was associated with a reduction in the number of unnecessary medications prescribed for older veterans in this nursing home. Future studies should evaluate the impact of decreasing unnecessary prescribing on clinical outcomes such as adverse drug reactions. PMID: 19281937 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=2263558 Sun, 01 Feb 2009 05:00:00 +0100 2263558 http://www.medworm.com/index.php?rid=2263553&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19281938%26dopt%3DAbstract Conclusions: Various factors make the effect of concomitant administration of meropenem and valproic acid unpredictable, even in the same patient. Caution should be used when administering meropenem and valproic acid concomitantly, especially in elderly patients with central nervous system disorders, even if the patient has had a successful prior experience with these 2 drugs. If concomitant administration is essential, very close serum concentration monitoring and clinical observation are necessary. PMID: 19281938 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=2263553 Sun, 01 Feb 2009 05:00:00 +0100 2263553 http://www.medworm.com/index.php?rid=2263548&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19281939%26dopt%3DAbstract Conclusion: In the absence of definitive evidence of effectiveness, trials of low-dose methylphenidate in medically ill adults with depression, fatigue, or apathy, with monitoring for response and adverse effects, are appropriate. PMID: 19281939 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=2263548 Sun, 01 Feb 2009 05:00:00 +0100 2263548 http://www.medworm.com/index.php?rid=2263543&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19281940%26dopt%3DAbstract Authors: Hanlon JT PMID: 19281940 [PubMed - as supplied by publisher] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=2263543 Sun, 01 Feb 2009 05:00:00 +0100 2263543 http://www.medworm.com/index.php?rid=2263540&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19281941%26dopt%3DAbstract Authors: Guay DR PMID: 19281941 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=2263540 Sun, 01 Feb 2009 05:00:00 +0100 2263540 http://www.medworm.com/index.php?rid=2131202&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19161926%26dopt%3DAbstract Conclusions: Based on the prevalence of medication and nonmedication therapies, levels of osteoporosis care did not differ by ambulatory care setting. However, patterns of care varied by certain visit characteristics, including insurance type, age, and sex. PMID: 19161926 [PubMed - as supplied by publisher] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=2131202 Mon, 01 Dec 2008 05:00:00 +0100 2131202 http://www.medworm.com/index.php?rid=2131201&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19161927%26dopt%3DAbstract Conclusion: Almost 30% of patients receiving a PPI in this academic geriatric practice had no documented indication for PPI use. PMID: 19161927 [PubMed - as supplied by publisher] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=2131201 Mon, 01 Dec 2008 05:00:00 +0100 2131201 http://www.medworm.com/index.php?rid=2131200&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19161928%26dopt%3DAbstract Conclusions: In this sample of older patients assessed for medication management, independent cognitive processes were associated with the ability to set up a medication schedule and overall adherence to prescriptions. Better verbal memory functioning was strongly and independently associated with setting up a medication schedule, while better executive functioning was strongly and independently associated with being fully adherent to prescription instructions. Deficits in either cognitive ability could result in medication errors due to nonadherence. PMID: 19161928 [PubMed - as supplied by publisher] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=2131200 Mon, 01 Dec 2008 05:00:00 +0100 2131200 http://www.medworm.com/index.php?rid=2131199&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19161929%26dopt%3DAbstract Conclusion: Based on this outcome in this patient with UTI, fluoroquinolones should be used with caution, particularly in patients with risk factors predisposing to tendinitis, including advanced age and renal dysfunction. PMID: 19161929 [PubMed - as supplied by publisher] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=2131199 Mon, 01 Dec 2008 05:00:00 +0100 2131199 http://www.medworm.com/index.php?rid=2131198&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19161930%26dopt%3DAbstract Conclusions: In general, unless the patient is engaging in or threatening dangerous acts involving physical contact, serotoninergics (first choice, SSRIs; second choice, TCAs) are first-line agents followed by antiandrogens (cyproterone acetate or medroxyprogesterone acetate) as second-line agents. LHRH agonists (first choice) and estrogens (second choice) are considered third-line agents. Combination therapy is reasonable if the patient fails to respond to monotherapy. PMID: 19161930 [PubMed - as supplied by publisher] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=2131198 Mon, 01 Dec 2008 05:00:00 +0100 2131198 http://www.medworm.com/index.php?rid=2131197&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19161931%26dopt%3DAbstract Authors: Guay DR PMID: 19161931 [PubMed - as supplied by publisher] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=2131197 Mon, 01 Dec 2008 05:00:00 +0100 2131197 http://www.medworm.com/index.php?rid=1990370&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19028374%26dopt%3DAbstract Conclusions: Nearly 1 in 4 elderly nursing home residents in the United States received antipsychotic agents. Predisposing and need factors played a vital role in determining the use of antipsychotic agents in these elderly patients. Overall, the study findings suggest that there is a need to monitor antipsychotic drug use by elderly patients in US nursing homes in light of recent efficacy and safety data on atypical agents. PMID: 19028374 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=1990370 Wed, 01 Oct 2008 04:00:00 +0100 1990370 http://www.medworm.com/index.php?rid=1990369&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19028375%26dopt%3DAbstract Conclusion: In this population of community-dwelling elderly, use of typical agents was associated with an increased risk for hospitalization compared with atypical agents. PMID: 19028375 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=1990369 Wed, 01 Oct 2008 04:00:00 +0100 1990369 http://www.medworm.com/index.php?rid=1990368&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19028376%26dopt%3DAbstract Conclusions: The intervention to improve patient safety by reducing medication delays for patients making the transition from the hospital to the NH was not successfully implemented, as medication orders were not transmitted to the NH-contracted pharmacies before patients' arrival at the NH. All patients making the transition from hospital to NH experienced a >12-hour delay in medication administration, and the mean number of missed doses of medications was >3. There is a need for further exploration of the reasons for and possible solutions to delays in medication administration during the transition to the NH, as well as of the impact of such delays on patient outcomes, including adverse drug events, emergency department visits, and rehospitalizations. PMID: 19028376 [PubMed - ... The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=1990368 Wed, 01 Oct 2008 04:00:00 +0100 1990368 http://www.medworm.com/index.php?rid=1990367&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19028377%26dopt%3DAbstract Conclusions: Among 48,512 medications inspected over 8 weeks in 3 German long-term care facilities, the rate of repackaging errors was 1.3%, involving 7.3% of daily pill organizers and the medications of 53.00% of residents. The largest proportion of errors involved incorrect halving of tablets. PMID: 19028377 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=1990367 Wed, 01 Oct 2008 04:00:00 +0100 1990367 http://www.medworm.com/index.php?rid=1990366&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19028378%26dopt%3DAbstract Conclusion: This longitudinal study is an initial step toward developing more comprehensive, patient-centered measures and interventions to address the quality of medication use in older adults. PMID: 19028378 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=1990366 Wed, 01 Oct 2008 04:00:00 +0100 1990366 http://www.medworm.com/index.php?rid=1779021&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18775387%26dopt%3DAbstract Authors: Donoso VS PMID: 18775387 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=1779021 Mon, 01 Sep 2008 04:00:00 +0100 1779021 http://www.medworm.com/index.php?rid=1779020&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18775388%26dopt%3DAbstract Conclusions: Compared with the IPR cohort, the FSC 500/50 cohort was 45% less likely to have a COPD-related exacerbation event and had similar medical costs. FSC 500/50 was a more effective initial maintenance therapy than IPR for this Medicare population, and, despite the $260 increase in COPD-related pharmacy costs, there was no significant difference in COPD-related medical costs. PMID: 18775388 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=1779020 Mon, 01 Sep 2008 04:00:00 +0100 1779020 http://www.medworm.com/index.php?rid=1779019&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18775389%26dopt%3DAbstract Conclusions: Despite research evidence and recommendations to avoid these CNS-active medications because of their adverse effects, they continue to be prescribed in elderly patients with cognitive impairments. Further research is needed to determine strategies that will help reduce their administration in this population. PMID: 18775389 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=1779019 Mon, 01 Sep 2008 04:00:00 +0100 1779019 http://www.medworm.com/index.php?rid=1779018&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18775390%26dopt%3DAbstract Conclusions: Although an MDRD equation may be useful for estimating GFR, the CG(CrCl)-Eq should still be used for drug dosage adjustments. The CG(CrCl)-Eq may require a slight "adjustment factor" to be applied using serum creatinine values measured by newly established assay procedures. PMID: 18775390 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=1779018 Mon, 01 Sep 2008 04:00:00 +0100 1779018 http://www.medworm.com/index.php?rid=1779017&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18775391%26dopt%3DAbstract Conclusions: Nearly 70% of patients admitted to a medical ward had >/=1 unspecified medication listed in the admission note. Based on these results, health care professionals must bc careful to obtain and document complete medication histories with matching indications. PMID: 18775391 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=1779017 Mon, 01 Sep 2008 04:00:00 +0100 1779017 http://www.medworm.com/index.php?rid=1779016&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18775392%26dopt%3DAbstract Conclusions: This case of adrenal insufficiency in an elderly woman was probably related to MA use. Clinicians should be alert to the possibility of this adverse effect when considering use of MA therapy. PMID: 18775392 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=1779016 Mon, 01 Sep 2008 04:00:00 +0100 1779016 http://www.medworm.com/index.php?rid=1779015&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18775393%26dopt%3DAbstract Conclusion: This report describes a case of a probable interaction between topical econazole lotion 1% and acenocoumarol that resulted in overanticoagulation and a life-threatening laryngeal hematoma in this elderly patient. PMID: 18775393 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=1779015 Mon, 01 Sep 2008 04:00:00 +0100 1779015 http://www.medworm.com/index.php?rid=1779014&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18775394%26dopt%3DAbstract Authors: Guay DR PMID: 18775394 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=1779014 Mon, 01 Sep 2008 04:00:00 +0100 1779014 http://www.medworm.com/index.php?rid=1682815&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18675764%26dopt%3DAbstract Conclusions: Darbepoetin alfa administered QM maintained Hb levels >/=11 g/dL in patients with CKD (not on dialysis) aged <65, 65 to 74, and >/=75 years. This treatment regimen may help optimize anemia management for older community-dwelling and long-term care patients. PMID: 18675764 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=1682815 Sun, 01 Jun 2008 04:00:00 +0100 1682815 http://www.medworm.com/index.php?rid=1682814&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18675765%26dopt%3DAbstract Conclusions: The study is using a rigorous randomized controlled research design, which will enhance the internal validity of its findings. Results of the study, which will be reported after the completion of follow-up data collection activities, will enable us to assess the effects of the intervention on both medication use and the incidence of falls. If the intervention is found to be effective, it will provide a resource for community pharmacists working with older adults at high risk of medication-related falls. PMID: 18675765 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=1682814 Sun, 01 Jun 2008 04:00:00 +0100 1682814 http://www.medworm.com/index.php?rid=1682813&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18675766%26dopt%3DAbstract Conclusion: A pharmacotherapist-led educational intervention improved the scores of medical students and house staff on a test evaluating knowledge of evidence-based recommendations for pharmacotherapy in the elderly. PMID: 18675766 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=1682813 Sun, 01 Jun 2008 04:00:00 +0100 1682813 http://www.medworm.com/index.php?rid=1682812&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18675767%26dopt%3DAbstract Conclusions: The likelihood of mirtazapine use causing hyponatremia in these 2 cases was "probable" according to criteria of the Naranjo Adverse Drug Reaction Probability Scale (score, 6). A review of published cases found that mirtazapine-associated hyponatremia occurred in patients aged >60 years, after a mean of 6.5 days and with doses as low as 7.5 mg daily. The mean sodium nadir was 117.2 mEq/L, but after stopping mirtazapine, the mean time to recovery was 11 days. Clinicians should be aware of the possibility of this reaction in elderly patients and should monitor sodium levels in high-risk patients if symptoms suggestive of hyponatremia develop. PMID: 18675767 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=1682812 Sun, 01 Jun 2008 04:00:00 +0100 1682812 http://www.medworm.com/index.php?rid=1682811&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18675768%26dopt%3DAbstract Conclusions: This is the first report of a possible interaction between propafenone and citalopram, which caused propafenone adverse effects (eg, dizziness, falls) and mimicked coronary artery disease. PMID: 18675768 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=1682811 Sun, 01 Jun 2008 04:00:00 +0100 1682811 http://www.medworm.com/index.php?rid=1682810&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18675769%26dopt%3DAbstract Conclusions: From a clinical perspective, these data further support the rationale for physicians to provide effective management of CVD risk factors and for patients to be compliant with such recommendations to possibly prevent cognitive decline/dementia.118). PMID: 18675769 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=1682810 Sun, 01 Jun 2008 04:00:00 +0100 1682810 http://www.medworm.com/index.php?rid=1682809&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18675770%26dopt%3DAbstract Conclusions: Various types of CDS interventions may be effective in improving medication prescribing in older adults, but few studies reported clinical outcomes related to changes in medication prescribing. Data from this study should help to guide refinement and testing of future CDS interventions that specifically target older adult populations that are taking multiple medications. PMID: 18675770 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=1682809 Sun, 01 Jun 2008 04:00:00 +0100 1682809 http://www.medworm.com/index.php?rid=1682808&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18675771%26dopt%3DAbstract Authors: Guay DR PMID: 18675771 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=1682808 Sun, 01 Jun 2008 04:00:00 +0100 1682808 http://www.medworm.com/index.php?rid=1360432&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18396243%26dopt%3DAbstract Conclusions: Bleeding pattern was similar in both age groups regarding severity, onset, anatomic site of bleeding, and INR values during the bleeding event. Risk factors for episodes of major bleeding, which are more of a clinical concern, are potentially modifiable. They include quality of anticoagulation control in both groups and number of medications in the older age group. PMID: 18396243 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=1360432 Sat, 01 Mar 2008 05:00:00 +0100 1360432 http://www.medworm.com/index.php?rid=1360431&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18396244%26dopt%3DAbstract Conclusions: We found antidepressant use to be low in these relatively poor, community-dwelling, ethnically diverse older adults with dysthymia and minor depression in 2000 through 2003, with 36.22% of participants using antidepressants at baseline. Antidepressant users were more likely to be taking other prescription medications than nonusers. PMID: 18396244 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=1360431 Sat, 01 Mar 2008 05:00:00 +0100 1360431 http://www.medworm.com/index.php?rid=1360430&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18396245%26dopt%3DAbstract Conclusions: Always inappropriate and rarely appropriate medication use decreased over time in this practice-based research network study. Additional studies of robust interventions for improving medication use in the elderly are warranted. PMID: 18396245 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=1360430 Sat, 01 Mar 2008 05:00:00 +0100 1360430 http://www.medworm.com/index.php?rid=1360429&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18396246%26dopt%3DAbstract Conclusions: This is the first case report, to our knowledge, describing paranoia as one of the symptoms associated with statin therapy. Our report suggests an adverse reaction due to the initiation of atorvastatin via the temporal relationship between the start of atorvastatin and symptom onset, as well as termination of therapy and subsequent symptom disappearance. Use of the Naranjo adverse drug reaction probability scale to assess causality revealed a "probable" association (score, 5) for this adverse event. This report emphasizes the possibility of paranoia as a CNS adverse effect due to statin therapy. Statins are frequently used in older populations and should therefore be considered when such CNS adverse effects occur during therapy. PMID: 18396246 [PubMed - in process] (Source... The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=1360429 Sat, 01 Mar 2008 05:00:00 +0100 1360429 http://www.medworm.com/index.php?rid=1360428&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18396247%26dopt%3DAbstract Conclusions: This adverse event is highly suggestive of a drug interaction caused primarily by metronidazole, which produces an increase in S-warfarin concentrations. Treatment provided by health care providers who were not familiar with the patient and the use of a different pharmacy (where the pharmacist was unaware of her current medications) likely contributed to the event. PMID: 18396247 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=1360428 Sat, 01 Mar 2008 05:00:00 +0100 1360428 http://www.medworm.com/index.php?rid=1360427&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18396248%26dopt%3DAbstract Authors: Guay DR PMID: 18396248 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=1360427 Sat, 01 Mar 2008 05:00:00 +0100 1360427 http://www.medworm.com/index.php?rid=1139642&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18179988%26dopt%3DAbstract Authors: Steinman MA PMID: 18179988 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=1139642 Sat, 01 Dec 2007 05:00:00 +0100 1139642 http://www.medworm.com/index.php?rid=1139641&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18179989%26dopt%3DAbstract Conclusions: We found a very high prevalence of unnecessary drug use in this older veteran outpatient population. Race, income, and polypharmacy, as well as health-related beliefs, were central factors associated with unnecessary drug use. PMID: 18179989 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=1139641 Sat, 01 Dec 2007 05:00:00 +0100 1139641 http://www.medworm.com/index.php?rid=1139640&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18179990%26dopt%3DAbstract The objective of this analysis was to determine the nature of incontinence diagnosed in men with benign prostatic hypertrophy (BPH), focusing on its incidence, prevalence, diagnostic workup, and management. Methods: A cohort of patients with BPH was identified in the Integrated Healthcare Information Services National Managed Care Benchmark Database (1997-2003). Age and duration in the database after the first diagnosis of BPH were used as matching strata. Therapeutic subgroups consisted of watchful waiting, g-blockers, 5-alpha-reductase inhibitors (5ARIs), and BPH-related surgery. Results: A total of 411,658 males with BPH were identified from 12,298,027 males (3.3%). Of the BPH cohort, 2.7% (n = 11,172) were identified as having incontinence; of these, 57.8% of patients were >/=65 yea... The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=1139640 Sat, 01 Dec 2007 05:00:00 +0100 1139640 http://www.medworm.com/index.php?rid=1139639&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18179991%26dopt%3DAbstract Conclusions: We concluded that vitamin D insufficiency was a common problem in this population of elderly patients who had recently suffered a hip fracture. This insufficiency was related only to serum calcium in multivariable controlled models but cannot be reliably identified or excluded by measuring serum calcium alone. Physicians should be encouraged to check and monitor patients' serum levels of 25-hydroxyvitamin D. PMID: 18179991 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=1139639 Sat, 01 Dec 2007 05:00:00 +0100 1139639 http://www.medworm.com/index.php?rid=1139638&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18179992%26dopt%3DAbstract Conclusions: Nephrologists and oncologists should be aware of allergic interstitial nephritis as an adverse effect related to this agent. Although there are no current recommendations for monitoring serum creatinine with sunitinib therapy, we recommend that serum creatinine and white cell count with differential be checked within 2 weeks of initiation of therapy with sunitinib to enable earlier diagnosis of this condition and avoid renal damage. PMID: 18179992 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=1139638 Sat, 01 Dec 2007 05:00:00 +0100 1139638 http://www.medworm.com/index.php?rid=1139637&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18179993%26dopt%3DAbstract Conclusions: Many studies have found that various numbers of medications are associated with negative health outcomes, but more research is needed to further delineate the consequences associated with unnecessary drug use in elderly patients. Health care professionals should be aware of the risks and fully evaluate all medications at each patient visit to prevent polypharmacy from occurring. PMID: 18179993 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=1139637 Sat, 01 Dec 2007 05:00:00 +0100 1139637 http://www.medworm.com/index.php?rid=1139636&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18179994%26dopt%3DAbstract Conclusions: Limited information is available on benefits and risks to guide an evidence-based approach to the pharmacologic prevention of aspiration pneumonia. Considering the high incidence of aspiration pneumonia in older adults, large randomized clinical trials on the effectiveness of pharmacologic interventions are warranted. (Am J Geriatr Pharmacother. 2007;5:352-362) Key words: aspiration pneumonia prevention ACE inhibitors dopamine agonists substance P. PMID: 18179994 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=1139636 Sat, 01 Dec 2007 05:00:00 +0100 1139636 http://www.medworm.com/index.php?rid=1139635&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18179995%26dopt%3DAbstract Authors: Guay DR PMID: 18179995 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=1139635 Sat, 01 Dec 2007 05:00:00 +0100 1139635 http://www.medworm.com/index.php?rid=1139634&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18179996%26dopt%3DAbstract Authors: Hanlon JT PMID: 18179996 [PubMed - as supplied by publisher] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=1139634 Sat, 01 Dec 2007 05:00:00 +0100 1139634 http://www.medworm.com/index.php?rid=1139633&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18179997%26dopt%3DAbstract Authors: Prasanna CL PMID: 18179997 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=1139633 Sat, 01 Dec 2007 05:00:00 +0100 1139633 http://www.medworm.com/index.php?rid=1022050&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17996657%26dopt%3DAbstract Conclusions: In this subset analysis of older adults with severe baseline sleep-onset difficulties, ramelteon 8 mg significantly and persistently reduced subjective reports of time to sleep onset during 5 weeks of nightly treatment. Ramelteon appeared to be an effective and well-tolerated treatment for these older adults with primary, chronic insomnia. PMID: 17996657 [PubMed - as supplied by publisher] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=1022050 Sat, 01 Sep 2007 04:00:00 +0100 1022050 http://www.medworm.com/index.php?rid=1022049&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17996658%26dopt%3DAbstract Conclusion: In this elderly patient population, rosuvastatin was a more effective treatment for reducing LDL-C levels and attaining NCEP ATP III LDL-C goals than the other statins. PMID: 17996658 [PubMed - as supplied by publisher] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=1022049 Sat, 01 Sep 2007 04:00:00 +0100 1022049 http://www.medworm.com/index.php?rid=1022048&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17996659%26dopt%3DAbstract Conclusions: This national study found that high-cost Medicare beneficiaries with DM received substantially less intensive antidiabetic regimens compared with those incurring more modest medical expenditures in 2002. Longitudinal analysis is necessary to determine whether this finding indicates suboptimal therapy or has a more benign explanation. However, the magnitude of the association warrants the attention of clinicians who treat elderly and disabled diabetic patients with high disease burden. PMID: 17996659 [PubMed - as supplied by publisher] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=1022048 Sat, 01 Sep 2007 04:00:00 +0100 1022048 http://www.medworm.com/index.php?rid=1022047&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17996660%26dopt%3DAbstract Conclusions: Patients with higher levels of agitation receiving divalproex had reduced agitation on the physical aggression subscale of the CMAI. Divalproex was less effective on physically nonaggressive behavior and verbal agitation. Irritability, as measured on the NPI-NH, was also reduced. Patients who received both divalproex and an antipsychotic agent were responsive at lower doses of divalproex. In either case, the effective dosage of divalproex was lower than that commonly used for epilepsy or mania in elderly patients. The most common adverse events included somnolence and gait disturbance. (Am J Geriatr Pharmacother. 2007;5:209-217). PMID: 17996660 [PubMed - as supplied by publisher] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=1022047 Sat, 01 Sep 2007 04:00:00 +0100 1022047 http://www.medworm.com/index.php?rid=1022046&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17996661%26dopt%3DAbstract Conclusions: Elderly patients are commonly encountered in the ICU setting. Only moderate correlations existed between clinical sedation levels and dose or plasma concentration of sedative/analgesic medications in this study population. Further work is needed to understand appropriate and feasible measures of exposure to sedatives/analgesics relating to clinical outcomes. (Am J Geriatr Pharmacother. 2007;5:218-231). PMID: 17996661 [PubMed - as supplied by publisher] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=1022046 Sat, 01 Sep 2007 04:00:00 +0100 1022046 http://www.medworm.com/index.php?rid=1022045&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17996662%26dopt%3DAbstract Conclusions: Initiation of warfarin in these patients with AF while in the hospital led to increased length of stay. A move toward starting anticoagulation in an outpatient setting could reduce length of hospital stay. (Am J Geriatr Pharmacother. 2007;5:232-235). PMID: 17996662 [PubMed - as supplied by publisher] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=1022045 Sat, 01 Sep 2007 04:00:00 +0100 1022045 http://www.medworm.com/index.php?rid=1022044&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17996663%26dopt%3DAbstract Conclusions: We report here a probable association between methimazole use and severe cholestatic jaundice in an elderly hyperthyroid patient. The patient's jaundice was reversed after drug discontinuation. (Am J Geriatr Pharmacother. 2007;5:236-240). PMID: 17996663 [PubMed - as supplied by publisher] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=1022044 Sat, 01 Sep 2007 04:00:00 +0100 1022044 http://www.medworm.com/index.php?rid=1022043&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17996664%26dopt%3DAbstract Conclusions: Given the cases presented, we recommend that clinicians measure electrolytes, blood urea nitrogen, and creatinine every 2 or 3 days for 1 or 2 weeks after initiating olanzapine treatment and after each dose increase. This is especially important for cognitively impaired elderly patients with BPH, as they may not be able to provide clear feedback regarding adverse effects of the medication. (Am J Geriatr Pharmacother. 2007;5:241-246). PMID: 17996664 [PubMed - as supplied by publisher] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=1022043 Sat, 01 Sep 2007 04:00:00 +0100 1022043 http://www.medworm.com/index.php?rid=1022042&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17996665%26dopt%3DAbstract Conclusions: It is noteworthy that while there have been a number of studies using these agents in the younger population, there continues to be a paucity of clinical trials targeting the elderly patient in particular; this continues to be an area of research interest. More clinical studies of these agents-conducted specifically in elderly patients with CLL, NHL, AML, and other hematologic malignancies-are needed. PMID: 17996665 [PubMed - as supplied by publisher] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=1022042 Sat, 01 Sep 2007 04:00:00 +0100 1022042 http://www.medworm.com/index.php?rid=1022041&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17996666%26dopt%3DAbstract Conclusions: There is a general trend of greater pharmacodynamic sensitivity in the elderly; however, this is not universal, and these age-related changes must be investigated agent-by-agent until further research yields greater understanding of the molecular mechanisms underlying the aging process. PMID: 17996666 [PubMed - as supplied by publisher] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=1022041 Sat, 01 Sep 2007 04:00:00 +0100 1022041 http://www.medworm.com/index.php?rid=1022040&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17996667%26dopt%3DAbstract Authors: Guay DR PMID: 17996667 [PubMed - as supplied by publisher] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=1022040 Sat, 01 Sep 2007 04:00:00 +0100 1022040 http://www.medworm.com/index.php?rid=827808&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17719511%26dopt%3DAbstract CONCLUSIONS:: Demographic and clinical predictors of TDF use differed from predictors of any LA opioid use among these older Medicaid beneficiaries. Qualitative research methods are needed to better understand what factors influence selection of opioid medications for older patients in nursing homes and community settings. PMID: 17719511 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=827808 Fri, 01 Jun 2007 04:00:00 +0100 827808 http://www.medworm.com/index.php?rid=827807&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17719512%26dopt%3DAbstract CONCLUSIONS:: Latanoprost therapy offered improved medication use behavior in these older adults enrolled in a Medicare HMO. There were no significant additional increases in overall health care costs as a result of introduction of latanoprost therapy, after adjusting for group and time effects, as well as other baseline confounders in this study cohort. PMID: 17719512 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=827807 Fri, 01 Jun 2007 04:00:00 +0100 827807 http://www.medworm.com/index.php?rid=827806&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17719513%26dopt%3DAbstract CONCLUSIONS:: For older patients with seizures who were unhappy with their AED regimen because of adverse effects, continuing seizures, or both, adding LTG to the drug regimen was associated with improved tolerability and effectiveness, and switching to LTG monotherapy was associated with further improvement. PMID: 17719513 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=827806 Fri, 01 Jun 2007 04:00:00 +0100 827806 http://www.medworm.com/index.php?rid=827805&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17719514%26dopt%3DAbstract CONCLUSIONS:: The majority of approved requests for wet nebulization criteria fell within the established reimbursement guidelines. Many approvals outside of guidelines were clinically valid. Approval of requests outside the criteria highlights the need for flexibility in the claims administrative and adjudication system to respond to unique circumstances not covered by established criteria. However, concurrent use of wet nebulization and portable inhalers by some beneficiaries suggests suboptimal use of portable inhalers, the need for portable inhalers for patients using wet nebulization when they leave their residence, and the need for more patient education. PMID: 17719514 [PubMed - as supplied by publisher] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=827805 Fri, 01 Jun 2007 04:00:00 +0100 827805 http://www.medworm.com/index.php?rid=827804&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17719515%26dopt%3DAbstract CONCLUSION:: Although laxatives are widely recommended in patients taking opioids, only 66% of elderly LTC residents in this study received this standard of care. PMID: 17719515 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=827804 Fri, 01 Jun 2007 04:00:00 +0100 827804 http://www.medworm.com/index.php?rid=827803&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17719516%26dopt%3DAbstract Authors: Bodenner D, Spencer T, Riggs AT, Redman C, Strunk B, Hughes T Abstract BACKGROUND:: Megestrol acetate (MA) is a progestin widely used to treat weight loss and cachexia in patients suffering from AIDS or cancer. Although MA is also frequently prescribed for similarly malnourished elderly individuals, the efficacy and morbidity of MA treatment in this patient population remain unclear. OBJECTIVE:: The goal of this study was to cxaminc the effects of MA therapy on weight and overall mortality in elderly nursing home residents. METHODS:: This was a case-control cohort study of 17,328 nursing home residents admitted to Beverly Healthcare nursing home between January 1, 2000, and December 31, 2003, who had lost either 5% of total body weight within 3 months or 10% of total body weig... The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=827803 Fri, 01 Jun 2007 04:00:00 +0100 827803 http://www.medworm.com/index.php?rid=827802&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17719517%26dopt%3DAbstract CONCLUSIONS:: Analgesic, psychotropic, and anticholinergic medications that should be avoided contributed to higher rates of inappropriate drug use among older women than among older men. Targeted efforts to avoid these medications in older women may help reduce overall rates of inappropriate prescribing. Sex-stratified reporting of quality indicators that assess inappropriate prescribing among community-dwelling elders would help monitor the effectiveness of improvement efforts. PMID: 17719517 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=827802 Fri, 01 Jun 2007 04:00:00 +0100 827802 http://www.medworm.com/index.php?rid=827801&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17719518%26dopt%3DAbstract CONCLUSIONS:: Caution should be exercised in prescribing DXM to geriatric patients, as they may be more susceptible to the drug's adverse effects because of increased clearance time. It appears that dose may play a greater role in causing psychosis, rather than the rate of metabolism, as evident in our patient who, contrary to the more oftendescribed scenario, was a slow metabolizer at CYP2D6. PMID: 17719518 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=827801 Fri, 01 Jun 2007 04:00:00 +0100 827801 http://www.medworm.com/index.php?rid=827800&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17719519%26dopt%3DAbstract Authors: Guay DR PMID: 17719519 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=827800 Fri, 01 Jun 2007 04:00:00 +0100 827800 http://www.medworm.com/index.php?rid=827799&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17719520%26dopt%3DAbstract Authors: Hermanowicz N PMID: 17719520 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=827799 Fri, 01 Jun 2007 04:00:00 +0100 827799 http://www.medworm.com/index.php?rid=827798&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17719521%26dopt%3DAbstract Authors: Guay DR PMID: 17719521 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=827798 Fri, 01 Jun 2007 04:00:00 +0100 827798 http://www.medworm.com/index.php?rid=716368&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17608242%26dopt%3DAbstract CONCLUSIONS: Vitamin D insufficiency is prevalent in ambulatory, and especially obese, elderly living in Denver, Colorado, despite vitamin D intake consistent with national recommendations. Dietary intake of vitamin D appeared to be unreliable to prevent insufficiency. Based on our results, along with other published data, we feel that national recommendations for vitamin D intake in the elderly should be increased to at least 800 to 1000 IU/d of over-the-counter supplemental cholecalciferol. PMID: 17608242 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=716368 Thu, 01 Mar 2007 05:00:00 +0100 716368 http://www.medworm.com/index.php?rid=716367&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17608243%26dopt%3DAbstract CONCLUSIONS: To detect and prevent problems with antidepressant therapy, primary care clinics should consider having nonphysician health care personnel ask patients taking antidepressant medication at least one open-ended question about how the antidepressant is working, another about possible adverse effects or barriers to use, and a third about adherence. PMID: 17608243 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=716367 Thu, 01 Mar 2007 05:00:00 +0100 716367 http://www.medworm.com/index.php?rid=716366&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17608244%26dopt%3DAbstract CONCLUSION: In this cohort, despite a high self-reported understanding of DM and its treatment, 24.5% of subjects made at least 1 error in accurately recalling their medication regimen. PMID: 17608244 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=716366 Thu, 01 Mar 2007 05:00:00 +0100 716366 http://www.medworm.com/index.php?rid=716365&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17608245%26dopt%3DAbstract CONCLUSIONS: In this study population, the number of prescribing physicians was an independent risk factor for patients self-reporting an ADE. More research is needed to confirm and explain this finding. One possibility is poor communication between multiple providers. Physicians should work to ensure more effective coordination of care between providers and communicate information about all medications prescribed to their patients with their colleagues. PMID: 17608245 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=716365 Thu, 01 Mar 2007 05:00:00 +0100 716365 http://www.medworm.com/index.php?rid=716364&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17608246%26dopt%3DAbstract CONCLUSIONS: By using the MAI for evaluation, pharmacist recommendations significantly improved the appropriateness of medication use among veterans receiving home health care. A majority of pharmacist recommendations were accepted. PMID: 17608246 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=716364 Thu, 01 Mar 2007 05:00:00 +0100 716364 http://www.medworm.com/index.php?rid=716363&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17608247%26dopt%3DAbstract CONCLUSIONS: Severe C difficile colitis has been reported more frequently in the literature recently, especially in elderly patients. Tissue culture assay is the best diagnostic test to detect the cytotoxin; enzyme immunoassay is the test used in most hospitals, but it has a sensitivity of only -75%. Treatment options remain limited to eradicate this serious infection. Antibiotic therapy, infection control measures, and early diagnosis are essential components of successful outcome for this disease. This patient's infection resolved with the addition of IVIG with no recurrence, suggesting the possible benefit of this treatment in certain patients with severe colitis who do not respond to standard therapy. PMID: 17608247 [PubMed - in process] (Source: The American Journal of Geriatric P... The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=716363 Thu, 01 Mar 2007 05:00:00 +0100 716363 http://www.medworm.com/index.php?rid=716362&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17608248%26dopt%3DAbstract CONCLUSIONS: Extension of treatment guidelines should consider an individual's global risk of coronary heart disease. However, due to the prevalence of subclinical disease in older adults, risk may be higher or otherwise differ with age. In addition, tolerance for and barriers to adherence with long-term medical therapy are important treatment considerations in older adults. Prospective, randomized controlled trials that better define the tolerability, safety, and efficacy of statin therapy in older adults with elevated cholesterol levels and intermediate cardiovascular risk are needed. PMID: 17608248 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=716362 Thu, 01 Mar 2007 05:00:00 +0100 716362 http://www.medworm.com/index.php?rid=716361&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17608249%26dopt%3DAbstract CONCLUSIONS: Older adults who drink alcohol and who take medications are at risk for a variety of adverse consequences depending on the amount of alcohol and the type of medications consumed. It is important for clinicians to know how much alcohol their older patients are drinking to be able to effectively assess their risks and to counsel them about the safe use of alcohol and medications. Similarly, it is important for older adults to understand the potential risks of their combined alcohol and medication use to avoid the myriad of problems possible with unsafe use of these substances.. PMID: 17608249 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=716361 Thu, 01 Mar 2007 05:00:00 +0100 716361 http://www.medworm.com/index.php?rid=716360&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17608250%26dopt%3DAbstract CONCLUSION: Data from recently published studies may provide guidance to practitioners and help direct future research. PMID: 17608250 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=716360 Thu, 01 Mar 2007 05:00:00 +0100 716360 http://www.medworm.com/index.php?rid=414624&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17296534%26dopt%3DAbstract Authors: Donoso VS PMID: 17296534 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=414624 Fri, 01 Dec 2006 07:00:00 +0100 414624 http://www.medworm.com/index.php?rid=414623&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17296535%26dopt%3DAbstract CONCLUSIONS:: Interventions targeted specifically at BC medications would have seemingly done little to change the risk of ADEs in this population. Interventions that are more comprehensive than the BC are necessary to reduce the risk of ADEs and the associated morbidity and mortality in acute care of the elderly. PMID: 17296535 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=414623 Fri, 01 Dec 2006 07:00:00 +0100 414623 http://www.medworm.com/index.php?rid=414622&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17296536%26dopt%3DAbstract CONCLUSIONS:: In outpatient settings, elderly patients with pain and back or joint disorders tend to use NSAIDs more often and opioids less often than younger patients, suggesting that older patients may be receiving a poorer quality of pain management in outpatient settings. PMID: 17296536 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=414622 Fri, 01 Dec 2006 07:00:00 +0100 414622 http://www.medworm.com/index.php?rid=414621&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17296537%26dopt%3DAbstract CONCLUSIONS:: Prescription pain medication use was associated with pain frequency/severity after adjusting for sociodemographics and OTC pain medications in this study of community-dwelling older adults, suggesting that even with medications, individuals remained in pain. PMID: 17296537 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=414621 Fri, 01 Dec 2006 07:00:00 +0100 414621 http://www.medworm.com/index.php?rid=414620&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17296538%26dopt%3DAbstract CONCLUSIONS:: Although the probability of true cross-reactivity is not known, clinicians should be aware that an allergic-like reaction to sulfonamide-containing nonantibiotics may occur in patients with known allergies to sulfonamide-containing antibiotics. These patients should be monitored closely when receiving these drugs. Further evaluation is needed to determine whether angioedema should be added to the list of adverse events associated with HCTZ. PMID: 17296538 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=414620 Fri, 01 Dec 2006 07:00:00 +0100 414620 http://www.medworm.com/index.php?rid=414619&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17296539%26dopt%3DAbstract CONCLUSIONS:: Despite the well-documented selectivity of rasagiline, the manufacturer recommends virtually all of the dietary (vis-à-vis tyramine) and drug restrictions of the nonselective MAO inhibitors. Although useful, selective MAO-B inhibitors have a limited role in Parkinson's disease. Of greater interest is the potential neuroprotective effect of rasagiline and its major metabolite, 1(R)-aminoindan, which may have great utility in a wide variety of neurodegenerative disorders of aging. In addition, bifunctional molecules combining selective MAO-B inhibition (based on the active moiety of rasagiline) with acetylcholinesterase inhibition or iron chelation may eventually be useful in Alzheimer's disease. PMID: 17296539 [PubMed - in process] (Source: The American Journal of Geriatr... The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=414619 Fri, 01 Dec 2006 07:00:00 +0100 414619 http://www.medworm.com/index.php?rid=414618&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17296540%26dopt%3DAbstract CONCLUSIONS:: The data for the treatment of late-life bipolar disorder are limited, but the available evidence shows efficacy for some commonly used treatments. Lithium, divalproex sodium, carbamazepine, lamotrigine, atypical antipsychotics, and antidepressants have all been found to be beneficial in the treatment of elderly patients with bipolar disorder. Although there are no specific guidelines for the treatment of these patients, monotherapy followed by combination therapy of the various classes of drugs may help with the resolution of symptoms. ECT and psychotherapy may be useful in the treatment of refractory disease. There is a need for more controlled studies in this age group before definitive treatment strategies can be enumerated. PMID: 17296540 [PubMed - in process] (Source... The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=414618 Fri, 01 Dec 2006 07:00:00 +0100 414618 http://www.medworm.com/index.php?rid=414617&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17296541%26dopt%3DAbstract CONCLUSIONS:: Patients at risk for PAD should be routinely screened, and appropriate management including antiplatelet therapy and risk factor modifications should be initiated once the disease is recognized. PMID: 17296541 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=414617 Fri, 01 Dec 2006 07:00:00 +0100 414617 http://www.medworm.com/index.php?rid=414616&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17296542%26dopt%3DAbstract CONCLUSIONS:: Psychoactive medications with abuse potential are used by at least 1 in 4 older adults, and such use is likely to grow as the population ages. The treatment of disorders of prescription drug use in older adults may involve family and caretakers, and should take into account the unique physical, emotional, and cognitive factors of aging. Further research is needed on the epidemiologic, health services, and treatment aspects of drug abuse in older adults, as well as the development of appropriate screening and diagnostic tools. PMID: 17296542 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=414616 Fri, 01 Dec 2006 07:00:00 +0100 414616 http://www.medworm.com/index.php?rid=414615&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17296543%26dopt%3DAbstract Authors: Guay DR PMID: 17296543 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=414615 Fri, 01 Dec 2006 07:00:00 +0100 414615 http://www.medworm.com/index.php?rid=393794&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17062320%26dopt%3DAbstract CONCLUSION: In this small study in elderly patients with comorbid MDD and GAD, treatment with escitalopram 10 to 20 mg/d for 12 weeks was associated with significant improvements in symptoms of depression and anxiety. PMID: 17062320 [PubMed - indexed for MEDLINE] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=393794 Fri, 01 Sep 2006 06:00:00 +0100 393794 http://www.medworm.com/index.php?rid=393793&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17062321%26dopt%3DAbstract CONCLUSIONS: In this study in an older population, coxibs constituted almost two thirds of all initial anti-inflammatory prescriptions. The prescription of a coxib was influenced by concomitant anticoagulant use and chronic use. Blacks were significantly more likely than whites to receive a nonselective NSAID. Although coxib use has been affected by the association with cardiovascular risk that emerged after the period of this study, rational drug selection and reduction of racial/ethnic disparities remain important targets for improved quality of care. PMID: 17062321 [PubMed - indexed for MEDLINE] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=393793 Fri, 01 Sep 2006 06:00:00 +0100 393793 http://www.medworm.com/index.php?rid=393792&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17062322%26dopt%3DAbstract CONCLUSIONS: The results of this cohort database study suggest that propoxyphene use among adults aged > or =65 years is associated with increased risk for hip fracture and suggest a need for interventions to reduce propoxyphene use in older adults. Clinicians should be aware of the risk for hip fracture with other opioids as well and weigh them against potential benefits when prescribing for older adults. PMID: 17062322 [PubMed - indexed for MEDLINE] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=393792 Fri, 01 Sep 2006 06:00:00 +0100 393792 http://www.medworm.com/index.php?rid=393789&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17062323%26dopt%3DAbstract CONCLUSIONS: Psychotropic medication use was high in CRC facilities (46.8%), with antidepressants being the most frequently used drugs. Use of suboptimal (19.3% of antidepressant users, 16.7% of sedative/anxiolytic users, 7.3% of antipsychotic users) and multiple psychotropics (16.7%) was low. PMID: 17062323 [PubMed - indexed for MEDLINE] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=393789 Fri, 01 Sep 2006 06:00:00 +0100 393789 http://www.medworm.com/index.php?rid=393785&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17062324%26dopt%3DAbstract CONCLUSIONS: Pharmacist medication reconciliation and communication with the physician reduced discrepancy-related ADEs in these patients transferred between the hospital and nursing home. Studies are needed to identify the most efficient ways of carrying out this task and to adapt the reconciliation process to all care settings. PMID: 17062324 [PubMed - indexed for MEDLINE] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=393785 Fri, 01 Sep 2006 06:00:00 +0100 393785 http://www.medworm.com/index.php?rid=393780&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17062325%26dopt%3DAbstract CONCLUSION: The results of this follow-up study suggest that current use of low-dose aspirin was not associated with increased mortality in these hospitalized patients with PUB. PMID: 17062325 [PubMed - indexed for MEDLINE] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=393780 Fri, 01 Sep 2006 06:00:00 +0100 393780 http://www.medworm.com/index.php?rid=393777&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17062326%26dopt%3DAbstract CONCLUSIONS: Use of nonselective NSAIDs is a significant risk factor for PUD-related hospitalizations among older adults in Argentina. The magnitude of the risk ratio resembles that reported for developed countries. PMID: 17062326 [PubMed - indexed for MEDLINE] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=393777 Fri, 01 Sep 2006 06:00:00 +0100 393777 http://www.medworm.com/index.php?rid=393773&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17062327%26dopt%3DAbstract CONCLUSIONS: We report a rare association of linezolid and tongue discoloration in an elderly kidney transplant recipient that improved with discontinuation. We present this case to increase clinicians' awareness of the potential adverse event. PMID: 17062327 [PubMed - indexed for MEDLINE] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=393773 Fri, 01 Sep 2006 06:00:00 +0100 393773 http://www.medworm.com/index.php?rid=393771&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17062328%26dopt%3DAbstract CONCLUSIONS: Medication-related adverse events are common in the nursing home setting. Additional studies are needed to enhance the detection and prevention of medication-related adverse events and to reduce their impact on residents' outcomes and health care costs. PMID: 17062328 [PubMed - indexed for MEDLINE] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=393771 Fri, 01 Sep 2006 06:00:00 +0100 393771 http://www.medworm.com/index.php?rid=393768&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17062329%26dopt%3DAbstract CONCLUSIONS: A substantial relation has not been established between sex and the second-generation ChEIs currently used in clinical settings for the treatment of AD. If an interaction between sex and ChEI treatment does exist, as suggested in 10 of the studies we analyzed, it is likely to be small and subtle, with much individual variation, as is the case with most neurologic sex differences. Nevertheless, sexual dimorphism in response to ChEI therapy warrants further investigation, especially in regard to its role in the development of novel AD therapies. PMID: 17062329 [PubMed - indexed for MEDLINE] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=393768 Fri, 01 Sep 2006 06:00:00 +0100 393768 http://www.medworm.com/index.php?rid=393765&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17062331%26dopt%3DAbstract Authors: Drinka PJ PMID: 17062331 [PubMed - indexed for MEDLINE] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=393765 Fri, 01 Sep 2006 06:00:00 +0100 393765 http://www.medworm.com/index.php?rid=393803&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16860256%26dopt%3DAbstract Authors: Fillenbaum GG, Hanlon JT PMID: 16860256 [PubMed - indexed for MEDLINE] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=393803 Thu, 01 Jun 2006 06:00:00 +0100 393803 http://www.medworm.com/index.php?rid=393802&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16860257%26dopt%3DAbstract CONCLUSIONS: Differences in factors identified in the Andersen model of access to care do not fully explain observed disparities in prescription drug use and spending. The portion of the disparities due to race and ethnicity may reflect patients' skepticism about medicine and medical care in general, patients' adherence to medical advice, patient-physician communication, physicians' prescribing habits, and usual source of care. Future research should explore whether these and other unobserved factors associated with race and ethnicity are responsible for disparities in drug spending and use. PMID: 16860257 [PubMed - indexed for MEDLINE] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=393802 Thu, 01 Jun 2006 06:00:00 +0100 393802 http://www.medworm.com/index.php?rid=393801&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16860258%26dopt%3DAbstract CONCLUSIONS: This pooled analysis of 50 published and unpublished studies in elderly patients found that the overall prevalences of AEs did not appear to increase with dose and appeared comparable to that observed with placebo. Although the prevalences of ALT/AST elevations appeared slightly higher in the 80-mg/d group (3.2% vs < or =0.9% in all other groups), specific musculoskeletal and hepatic AEs were rare (< or =3.0%). The rates of discontinuation appeared comparable between all 4 doses of atorvastatin and placebo. The results of this analysis support the favorable safety profile of atorvastatin across the full dose range in patients aged > or =65 years. PMID: 16860258 [PubMed - indexed for MEDLINE] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=393801 Thu, 01 Jun 2006 06:00:00 +0100 393801 http://www.medworm.com/index.php?rid=393800&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16860259%26dopt%3DAbstract CONCLUSIONS: In this post hoc analysis of data from elderly patients participating in 4 randomized clinical trials, PIO effectively controlled glycemic and lipid parameters over 52 weeks and was well tolerated. The effects seen in this analysis were comparable to those in the overall study populations. PMID: 16860259 [PubMed - indexed for MEDLINE] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=393800 Thu, 01 Jun 2006 06:00:00 +0100 393800 http://www.medworm.com/index.php?rid=393799&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16860260%26dopt%3DAbstract CONCLUSION: In this retrospective data analysis in this population of elderly patients receiving HHC in 2002, PIM and DDI were prevalent, and polypharmacy was associated with increased rates of PIM use and DDIs. PMID: 16860260 [PubMed - indexed for MEDLINE] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=393799 Thu, 01 Jun 2006 06:00:00 +0100 393799 http://www.medworm.com/index.php?rid=393798&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16860261%26dopt%3DAbstract CONCLUSIONS: The MMAA and DRUGS tools correlated positively with cognitive function in this population of community-living elderly persons but need further evaluation of their ability to predict who is at greatest risk for drug related problems due to nonadherence to medication regimens. PMID: 16860261 [PubMed - indexed for MEDLINE] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=393798 Thu, 01 Jun 2006 06:00:00 +0100 393798 http://www.medworm.com/index.php?rid=393797&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16860262%26dopt%3DAbstract CONCLUSIONS: The results of this study suggest that early effective dosing occurred more often with donepezil than with rivastigmine or galantamine in these nursing home residents. Almost half of residents discontinued donepezil, rivastigmine, or galantamine, whereas rates of switching from one ChEI to another were low. PMID: 16860262 [PubMed - indexed for MEDLINE] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=393797 Thu, 01 Jun 2006 06:00:00 +0100 393797 http://www.medworm.com/index.php?rid=393796&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16860263%26dopt%3DAbstract CONCLUSIONS: One third of initial antihypertensive prescriptions for elderly patients were for thiazides in our publicly funded health care system with universal drug coverage. Socioeconomic status did not influence use of thiazides, but age, sex, and comorbidities did. PMID: 16860263 [PubMed - indexed for MEDLINE] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=393796 Thu, 01 Jun 2006 06:00:00 +0100 393796 http://www.medworm.com/index.php?rid=393795&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16860264%26dopt%3DAbstract CONCLUSIONS: Long-term use of sedative-hypnotics for insomnia lacks an evidence base and has traditionally been discouraged for reasons that include concerns about such potential adverse drug effects as cognitive impairment (anterograde amnesia), daytime sedation, motor incoordination, and increased risk of motor vehicle accidents and falls. In addition, the effectiveness and safety of long-term use of these agents remain to be determined. More research is needed to evaluate the long-term effects of treatment and the most appropriate management strategy for elderly persons with chronic insomnia. PMID: 16860264 [PubMed - indexed for MEDLINE] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=393795 Thu, 01 Jun 2006 06:00:00 +0100 393795 http://www.medworm.com/index.php?rid=393812&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16730616%26dopt%3DAbstract CONCLUSIONS: The results of this subanalysis suggest that terbinafine was well tolerated and efficacious in these patients aged > or = 65 years with moderate to severe toenail onychomycosis, many of whom were taking antihypertensives, antidiabetics, or lipid-lowering agents concomitantly. There were no reported clinical signs of drug interactions. PMID: 16730616 [PubMed - indexed for MEDLINE] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=393812 Wed, 01 Mar 2006 07:00:00 +0100 393812 http://www.medworm.com/index.php?rid=393811&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16730617%26dopt%3DAbstract CONCLUSIONS: In these pooled analyses, solifenacin 5 and 10 mg once daily were efficacious and well tolerated in the treatment of these elderly subjects with OAB. Solifenacin therapy was also associated with a high level of persistence in a 40-week extension trial. PMID: 16730617 [PubMed - indexed for MEDLINE] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=393811 Wed, 01 Mar 2006 07:00:00 +0100 393811 http://www.medworm.com/index.php?rid=393810&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16730618%26dopt%3DAbstract CONCLUSIONS: These results provide the first nationally representative estimate of the concomitant use of APDs and antipsychotic drugs among older individuals in long-term care settings. The decrease in concomitant use of APDs and antipsychotics when SGAPs were used in NHs suggests an association between the use of SGAPs and a reduction in the prescribing cascade, in which one drug is used to treat the adverse effects of another. The results also suggest that some Medicare beneficiaries in ALFs may be continued on APDs despite changes in the prescribing of antipsychotic agents, implying a need for better medication-management practices in these institutions. PMID: 16730618 [PubMed - indexed for MEDLINE] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=393810 Wed, 01 Mar 2006 07:00:00 +0100 393810 http://www.medworm.com/index.php?rid=393809&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16730619%26dopt%3DAbstract CONCLUSION: A positive correlation between the use of >/=9 different scheduled medications and ADRs was found among these geriatric nursing home residents. PMID: 16730619 [PubMed - indexed for MEDLINE] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=393809 Wed, 01 Mar 2006 07:00:00 +0100 393809 http://www.medworm.com/index.php?rid=393808&cid=s_34436_18_f&fid=34436&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16730620%26dopt%3DAbstract CONCLUSIONS: Anticholinergic drug use was common (27.1%) in these elderly veterans with intact cognitive function. The mean number of anticholinergic symptoms was significantly greater in this group, and the prevalences of dry mouth and constipation were significantly higher in the group using anticholinergic drugs (all, P < 0.01). Anticholinergic-related ADEs were rare (0.8%). Although anticholinergic drugs should generally be avoided in the elderly, individual risks and benefits for a patient should be considered. PMID: 16730620 [PubMed - indexed for MEDLINE] (Source: The American Journal of Geriatric Pharmacotherapy) The American Journal of Geriatric Pharmacotherapy journals http://www.medworm.com/rss/comments.php?id=393808 Wed, 01 Mar 2006 07:00:00 +0100 393808