MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'The Breast Journal' source. Wed, 08 Feb 2012 08:41:57 +0100 http://www.medworm.com/index.php?rid=5659371&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01212.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5659371 Thu, 02 Feb 2012 05:00:00 +0100 5659371 http://www.medworm.com/index.php?rid=5659370&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01214.x Abstract:  Breast Molecular Imaging (or Breast‐Specific Gamma Imaging) has been previously shown to be both sensitive and specific for the detection of breast cancer. The purpose of our study was to retrospectively review all cases of Breast Molecular Imaging (BMI) performed at our institution to determine BMI’s potential role in Breast Imaging decision making. A total of 416 cases of BMI from January 2007 to November 2009 were analyzed and the following data were collected: indication for examination, BIRADS assignment after BMI, biopsy outcomes, sensitivity and specificity of the modality and patient follow‐up. Fifty‐six percent of cases were ordered for an indeterminate asymmetry or focal asymmetry, 14% for evaluation of calcifications, and less than 10% each for the remainder... The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5659370 Thu, 02 Feb 2012 05:00:00 +0100 5659370 http://www.medworm.com/index.php?rid=5659369&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01215.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5659369 Thu, 02 Feb 2012 05:00:00 +0100 5659369 http://www.medworm.com/index.php?rid=5646954&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01218.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5646954 Sun, 29 Jan 2012 05:00:00 +0100 5646954 http://www.medworm.com/index.php?rid=5646953&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01222.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5646953 Sun, 29 Jan 2012 05:00:00 +0100 5646953 http://www.medworm.com/index.php?rid=5580904&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01205.x Abstract:  Delays in treatment for breast cancer can lead to poorer patient outcome. We analyzed time to treatment among female patients receiving breast‐conserving surgery in two different hospital settings, public versus private. Retrospective chart review revealed 270 patients diagnosed during 2004–2008. Three consecutive time intervals were defined (Initial abnormal imaging [I] to core biopsy [II] to surgery /pathology staging [III] to oncology evaluation for adjuvant treatment). Multivariate analyses investigated hospital type and demographic factors. Overall median treatment time was 83 days, Interval II accounting for the longest (43 days). Only 55% of patients received the entire spectrum of care within 90 days; for each consecutive 30‐day interval, percentages varied... The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5580904 Thu, 12 Jan 2012 05:00:00 +0100 5580904 http://www.medworm.com/index.php?rid=5580903&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01213.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5580903 Thu, 12 Jan 2012 05:00:00 +0100 5580903 http://www.medworm.com/index.php?rid=5580905&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01202.x Abstract:  Breast cancer occurs earlier in Chinese women than in Caucasian women. We have compared the clinicopathologic characteristics and prognosis in very young and older premenopausal women with breast cancer in south China. We separated 905 consecutive premenopausal patients with first diagnosis of breast cancer, surgically treated at the Sun Yat‐sen University Cancer Center from October 2003 to December 2006, into a very young group (189 [13.7%]; <35 years old) and an older group (716 [52.0%]; 35–57 years old). Approximately, 90% of patients received adjuvant chemotherapy and hormonal therapy with tamoxifen for hormone‐receptor (HR)‐positive breast cancer. We retrospectively compared the clinicopathologic factors and survival rates of these two groups. The 3‐year ... The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5580905 Wed, 11 Jan 2012 05:00:00 +0100 5580905 http://www.medworm.com/index.php?rid=5659368&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01221.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5659368 Sun, 01 Jan 2012 05:00:00 +0100 5659368 http://www.medworm.com/index.php?rid=5646952&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01220.x This article aims to critically review the indications and limitations of NSM, discuss evidence based intra‐operative protocols and to discuss ways in which radiation therapy may be incorporated in treatment planning following NSM. A comprehensive search of the scientific literature was carried out using PubMed to access all publications related to nipple sparing mastectomy. The search focused specifically on technique, current management, safety, and complications of these procedures. Keywords searched included “Nipple sparing mastectomy,”“breast conserving surgery,”“Nipple areola complex preservation” and “skin sparing mastectomy.” NSM offers an opportunity to preserve native breast envelope without mutilation of nipple‐areola complex (NAC), and avoids multiple surgic... The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5646952 Sun, 01 Jan 2012 05:00:00 +0100 5646952 http://www.medworm.com/index.php?rid=5637966&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01211.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5637966 Sun, 01 Jan 2012 05:00:00 +0100 5637966 http://www.medworm.com/index.php?rid=5580909&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01200.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5580909 Sun, 01 Jan 2012 05:00:00 +0100 5580909 http://www.medworm.com/index.php?rid=5580908&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01185.x We report a case of male breast carcinoma in a patient with the BRCA2 mutation detected by screening mammography, and review the literature regarding screening mammography in men. (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5580908 Sun, 01 Jan 2012 05:00:00 +0100 5580908 http://www.medworm.com/index.php?rid=5580907&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01183.x We describe a model of knowledge acquisition that can provide a framework for exploring the process and types of knowledge that breast cancer patients gain following their diagnosis. The four types of knowledge presented in this model—authoritative, technical, embodied, and traditional—are described and potential sources discussed. An understanding of knowledge acquisition in early stage breast cancer patients can provide healthcare practitioners with an important framework for optimizing decision‐making in this population. (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5580907 Sun, 01 Jan 2012 05:00:00 +0100 5580907 http://www.medworm.com/index.php?rid=5580906&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01199.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5580906 Sun, 01 Jan 2012 05:00:00 +0100 5580906 http://www.medworm.com/index.php?rid=5580902&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01217.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5580902 Sun, 01 Jan 2012 05:00:00 +0100 5580902 http://www.medworm.com/index.php?rid=5551964&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01204.x This study examined the accuracy of magnetic resonance imaging (MRI) for assessment of DCIS size, and evaluated the effect of preoperative breast MRI on achievement of tumor‐free surgical margins after breast‐conserving surgery (BCS). One‐hundred and fifty‐eight female patients with DCIS were identified from a prospective database: 60 patients (62 cases) had preoperative breast MRI, and 98 patients did not have MRI. The accuracy of tumor size assessed by MRI was determined by comparison with histopathologic size. All patients underwent BCS initially. The rate of involved margins after resection was compared in MRI and no‐MRI groups. The overall correlation between MRI size and histopathologic size was high (p < 0.0001). MRI assessment of size was significantly more accurat... The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5551964 Fri, 30 Dec 2011 05:00:00 +0100 5551964 http://www.medworm.com/index.php?rid=5551963&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01208.x Conclusion: Breast cancer diagnosed at a young age (≤40 years) is correlated with higher recurrence rates. (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5551963 Fri, 30 Dec 2011 05:00:00 +0100 5551963 http://www.medworm.com/index.php?rid=5551962&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01206.x Abstract:  The main premise of this hypothesis is that breast cancer is caused by sexual frustration. Sexual frustration is triggered by multiple forms of dissonance between the absence or lack of sexual reward and the (un)conscious motivation to obtain these sexual rewards. I assume that neural and hormonal processes are capable of adjusting or distorting biologically active forms of specific sex hormones depending on experienced sexual stimuli. I hypothesize that prolonged sexual frustration will ultimately lead via aberrantly metabolized sex hormones to the development of breast cancer. Human female sexual behavior research links sexual frustration with breast cancer risk. The distinction between human female sexual behavior and reproduction is crucial to understand breast cancer risk... The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5551962 Fri, 30 Dec 2011 05:00:00 +0100 5551962 http://www.medworm.com/index.php?rid=5551961&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01207.x Abstract:  Despite the low likelihood of malignancy, it is recommended that all women with pathologic nipple discharge undergo duct excision based on the inadequate sensitivity of diagnostic modalities. However, these data originates prior to recent improvements in breast imaging. We performed a retrospective review of patients evaluated in the setting of modern diagnostic breast imaging. Of 175 women referred to our breast clinic with a primary complaint of nipple discharge, 142 (81%) had suspicious discharge. Of the 23 patients who opted for observation over duct excision, with a mean follow‐up of 3.3 years, none have been diagnosed with cancer. Among patients who proceeded with surgery, cancer was diagnosed in seven patients (5%). Six of the seven patients had either an abnormal m... The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5551961 Fri, 30 Dec 2011 05:00:00 +0100 5551961 http://www.medworm.com/index.php?rid=5551960&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01209.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5551960 Fri, 30 Dec 2011 05:00:00 +0100 5551960 http://www.medworm.com/index.php?rid=5431326&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01175.x Abstract:  Breast cancer that lacks expression of estrogen/progesterone receptors and overexpression of the human epidermal growth factor receptor2 (HER2), i.e. triple‐negative breast cancer (TNBC), is not amenable to current targeted therapies and carries a poor prognosis. This review discusses the natural history of TNBC and published literature in the relevant treatment landscape, with a focus on newer therapies. Compared with other subtypes of breast cancer, TN tumors have higher response rates to neoadjuvant chemotherapy; however, this advantage is not clearly translated into the metastatic setting and has not improved these patients’ overall survival. Numerous cytotoxic and targeted strategies have demonstrated efficacy or are under investigation. Strategies showing promise in ... The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5431326 Sun, 20 Nov 2011 05:00:00 +0100 5431326 http://www.medworm.com/index.php?rid=5431325&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01176.x Abstract:  One of the main characteristics of breast cancer is its capability to disseminate. Solitary pulmonary metastases from breast cancer occur rarely (0.4%). The aim of this study is to check whether or not the outcome following the surgical treatment of pulmonary metastases in patients with breast cancer is in accordance with the data in the literature and based on it to identify prognostic factors. We have reviewed retrospectively data for 33 patients who underwent 43 curative resections of breast cancer pulmonary metastases between 1997 and 2002 at our department. Potential prognostic factors affecting survival, namely survival after lung metastasectomy, assessed were disease‐free interval (DFI), the number and location of lung metastases, the diameter in mm of metastases and ... The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5431325 Sun, 20 Nov 2011 05:00:00 +0100 5431325 http://www.medworm.com/index.php?rid=5431324&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01179.x Abstract:  With the increases in complexity of care for breast health concerns, there is a growing need for efficient and effective clinical evaluation, especially for vulnerable populations at risk for poor outcomes. The Breast Health Center at Boston Medical Center is a multidisciplinary program, with internists providing care alongside breast surgeons, radiologists, and patient navigators. Using a triage system previously shown to have high provider and patient satisfaction, and the ability to provide timely care, patients are assigned to either a breast surgeon or internist. From 2007 to 2009, internists cared for 2,408 women, representing half of all referrals. Women served were diverse in terms of race (33% black, 30% Hispanic, 5% Asian), language (34% require language interpreter)... The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5431324 Sun, 20 Nov 2011 05:00:00 +0100 5431324 http://www.medworm.com/index.php?rid=5431323&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01180.x We report the utility of office‐based, nonimaged guided fine needle aspiration of palpable axillary lymph nodes in breast cancer patients. We examine the sensitivity and specificity of this procedure, and examine factors associated with a positive fine needle aspiration biopsy result.Abstract:  Although the utility of ultrasound‐guided fine needle aspiration biopsy (FNA) of axillary lymph nodes is well established, there is little data on nonimage guided office‐based FNA of palpable axillary lymphadenopathy. We investigated the sensitivity and specificity of nonimage‐guided FNA of axillary lymphadenopathy in patients presenting with breast cancer, and report factors associated with a positive FNA result. Retrospective study of 94 patients who underwent office‐based FNA of palpa... The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5431323 Sun, 20 Nov 2011 05:00:00 +0100 5431323 http://www.medworm.com/index.php?rid=5431322&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01182.x Abstract:  Radiation therapy has been shown to increase complication rates of tissue expander/implant breast reconstructions. The purpose of this study was to evaluate patient characteristics to assess their impact on complications. A retrospective review of patients who underwent mastectomy plus tissue expander/implant reconstruction from January 2000 to December 2006 was performed. The main outcome of interest was the development of postoperative complications. Analyses were performed to detect risk factors for complications. A total of 560 patients were included in the study. A total of 385 patients underwent unilateral and 174 underwent bilateral tissue expander/implant reconstructions, for a total of 733 reconstructions. A total complication rate of 31.8% and a major complication ra... The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5431322 Sun, 20 Nov 2011 05:00:00 +0100 5431322 http://www.medworm.com/index.php?rid=5431321&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01186.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5431321 Sun, 20 Nov 2011 05:00:00 +0100 5431321 http://www.medworm.com/index.php?rid=5431320&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01188.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5431320 Sun, 20 Nov 2011 05:00:00 +0100 5431320 http://www.medworm.com/index.php?rid=5431319&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01191.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5431319 Sun, 20 Nov 2011 05:00:00 +0100 5431319 http://www.medworm.com/index.php?rid=5431318&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01193.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5431318 Sun, 20 Nov 2011 05:00:00 +0100 5431318 http://www.medworm.com/index.php?rid=5431317&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01194.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5431317 Sun, 20 Nov 2011 05:00:00 +0100 5431317 http://www.medworm.com/index.php?rid=5431316&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01195.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5431316 Sun, 20 Nov 2011 05:00:00 +0100 5431316 http://www.medworm.com/index.php?rid=5384383&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01181.x This study aimed to determine whether women who started using the oral contraceptive pill (OCP) at an early age developed breast cancer earlier than women who started using the OCP later in life. A database review of 1,010 breast cancer patients, who had used the OCP at some point in their life, was carried out. Associations of age at OCP start with age at breast cancer diagnosis were determined by multiple linear regression analysis, considering year of birth, year of diagnosis, age at first pregnancy, number of live births, age at menarche, and length of OCP use. There was evidence of a linear trend between age at OCP start and age at breast cancer diagnosis. Women who started using the OCP aged 18 years or younger were, on average, 4 years younger at breast cancer diagnosis than wom... The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5384383 Tue, 08 Nov 2011 05:00:00 +0100 5384383 http://www.medworm.com/index.php?rid=5384382&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01187.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5384382 Tue, 08 Nov 2011 05:00:00 +0100 5384382 http://www.medworm.com/index.php?rid=5384381&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01189.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5384381 Tue, 08 Nov 2011 05:00:00 +0100 5384381 http://www.medworm.com/index.php?rid=5384380&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01196.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5384380 Tue, 08 Nov 2011 05:00:00 +0100 5384380 http://www.medworm.com/index.php?rid=5551959&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01210.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5551959 Tue, 01 Nov 2011 04:00:00 +0100 5551959 http://www.medworm.com/index.php?rid=5514993&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01203.x We report our experience with aromatase inhibitors as primary endocrine therapy for estrogen receptor positive breast cancer in postmenopausal woman who are impaired by other diseases, refuse surgery or are of old age. Fifty‐six patients with fifty‐seven ER+ operable breast cancers who refused surgery, were judged ineligible for surgery because of comorbidity, or were of old age were treated with endocrine therapy using aromatase inhibitors only. Digital mammography and high‐end breast ultrasound were used to assess tumor sizes. The mean age of the patients was 74 years (range 52–102 years). All patients suffered from breast cancer. The mean follow‐up interval was 40 months (range 5–92 months). Seven patients (12%) achieved complete clinical remission, 31 (57%) partial ... The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5514993 Tue, 01 Nov 2011 04:00:00 +0100 5514993 http://www.medworm.com/index.php?rid=5440270&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01197.x This article reviews the existing scientific evidence, the controversies surrounding local management, and clinical guidelines for DCIS based on the group consensus by the ACR Breast Expert Panel. The American College of Radiology Appropriateness Criteria are evidence‐based guidelines for specific clinical conditions that are reviewed every 2 years by a multidisciplinary expert panel. The guideline development and review include an extensive analysis of current medical literature from peer‐reviewed journals and the application of a well established consensus methodology (modified Delphi) to rate the appropriateness of imaging and treatment procedures by the panel. In those instances where evidence is lacking or not definitive, expert opinion may be used to recommend imaging or treatm... The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5440270 Tue, 01 Nov 2011 04:00:00 +0100 5440270 http://www.medworm.com/index.php?rid=5431315&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01192.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5431315 Tue, 01 Nov 2011 04:00:00 +0100 5431315 http://www.medworm.com/index.php?rid=5384387&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01169.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5384387 Tue, 01 Nov 2011 04:00:00 +0100 5384387 http://www.medworm.com/index.php?rid=5384386&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01157.x Abstract:  Most cases of breast cancer are diagnosed at early stage of disease; therefore, treatment is oriented to increase the disease‐free interval (DFI) and overall survival (OS). The prognosis, in comparison with other malignancies, has improved in the last decades as a result of mammographic screening. The aim of the study was to report the incidence of local and distant recurrence, DFI and OS in patients (pts) with stage I and stage II breast cancer over a period of 26 years divided into three groups. From January 1978 to December 2004, 927 women with early breast cancer (EBC) were included, 350 were stage I and 577 Stage II (AJCC 2002). Patients were divided according to the year of diagnosis into three periods of 10 years: Group A (1978–1987) 135 pts, Group B (1988–199... The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5384386 Tue, 01 Nov 2011 04:00:00 +0100 5384386 http://www.medworm.com/index.php?rid=5384385&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01198.x This study clearly shows that BCS is associated with excessive resection of healthy breast tissue while clear margins are not assured. Surgical factors should be modified to improve surgical accuracy. (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5384385 Tue, 01 Nov 2011 04:00:00 +0100 5384385 http://www.medworm.com/index.php?rid=5384384&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01149.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5384384 Tue, 01 Nov 2011 04:00:00 +0100 5384384 http://www.medworm.com/index.php?rid=5384379&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01190.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5384379 Tue, 01 Nov 2011 04:00:00 +0100 5384379 http://www.medworm.com/index.php?rid=5335025&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01178.x Abstract:  Axillary node dissection (ALND) is the standard of care for patients who have a positive sentinel lymph node (SLN) on sentinel lymph node biopsy (SLNB). We sought to identify a low‐risk patient population with positive SLN that may not need cALND. We analyzed SLNB for breast cancer at our institutions between 1999 and 2007. We identified 130 patients who had a positive SLN but did not undergo completion ALND. We evaluated clinical data, adjuvant treatment patterns and intermediate locoregional and distant events. The median patient age was 50; 19% had N0(i+) disease, 53% had micrometastatic (N1mi) disease, and 28% had macrometastasis. Eighty‐eight percent of patients underwent radiation therapy; 66 patients (51%) had documented nodal radiation (of these 50 were treated wit... The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5335025 Fri, 21 Oct 2011 04:00:00 +0100 5335025 http://www.medworm.com/index.php?rid=5335024&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01184.x Abstract:  Male breast cancer (MaleBC) is a rare tumor that has been insufficiently described in the Middle East. The purpose of this study is to report the first MaleBC series in Lebanon, describing its clinicopathologic and immunohistochemical phenotype, and how it compares with MaleBC in the West and with female breast cancer in Lebanon and the Middle East. Forty‐seven cases of MaleBC were reviewed. Results showed younger ages at presentation (62 years versus 67 years), higher incidence of lobular carcinoma (6% versus 1%), and more frequent p53 positivity and axillary node metastases in our series than in those reported about MaleBC. Other results such as higher estrogen receptor (ER) positivity and lower HER‐2/neu over‐expression were comparable to the literature. These fin... The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5335024 Fri, 21 Oct 2011 04:00:00 +0100 5335024 http://www.medworm.com/index.php?rid=5323615&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01165.x We present a case of bilateral orbital metastases from breast cancer successfully treated with stereotactic radiotherapy (SRT). A 38‐year‐old woman presented with decreased vision in the right eye for 3 weeks. Eight months previously, she underwent whole‐brain radiotherapy for multiple brain metastases from breast cancer. Visual acuity was hand motion, and the eyelid closed incompletely in the affected eye. Computed tomography scans showed a 3‐cm extraconal mass in the right orbit. She underwent temporary tarsorrhaphy followed by SRT. A total dose of 39 Gy was delivered to the right orbital mass in three daily fractions. Four months later, her visual function was normal in both eyes and the right orbital mass disappeared. A new lesion was detected in the left orbit. She underwe... The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5323615 Mon, 17 Oct 2011 04:00:00 +0100 5323615 http://www.medworm.com/index.php?rid=5323614&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01166.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5323614 Mon, 17 Oct 2011 04:00:00 +0100 5323614 http://www.medworm.com/index.php?rid=5323613&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01167.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5323613 Mon, 17 Oct 2011 04:00:00 +0100 5323613 http://www.medworm.com/index.php?rid=5323612&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01168.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5323612 Mon, 17 Oct 2011 04:00:00 +0100 5323612 http://www.medworm.com/index.php?rid=5323611&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01172.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5323611 Mon, 17 Oct 2011 04:00:00 +0100 5323611 http://www.medworm.com/index.php?rid=5323610&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01173.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5323610 Mon, 17 Oct 2011 04:00:00 +0100 5323610 http://www.medworm.com/index.php?rid=5323609&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01174.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5323609 Mon, 17 Oct 2011 04:00:00 +0100 5323609 http://www.medworm.com/index.php?rid=5296522&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01161.x We present a case of a patient with stage IIB breast cancer who developed clinical, radiographic, and pathologic evidence of hemorrhagic cystitis after a single 600 mg/m2 dose of cyclophosphamide. Three subsequent cycles of cyclophosphamide with the addition of IV hydration and MESNA were given without complication, and the patient’s urologic symptoms resolved. Repeat cystoscopy demonstrated pathologic resolution of the cystitis. We review the literature regarding proposed mechanisms of hemorrhagic cystitis, and discuss the applicability of these hypotheses in our patient. (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5296522 Wed, 05 Oct 2011 04:00:00 +0100 5296522 http://www.medworm.com/index.php?rid=5250208&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01163.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5250208 Fri, 23 Sep 2011 04:00:00 +0100 5250208 http://www.medworm.com/index.php?rid=5250212&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01153.x The objective of this study was to assess the minimum disease‐free and overall survival benefit acceptable to physicians and to women undergoing AI therapy to continue treatment beyond 5 years. A self‐administered survey was completed by women with stage I–III breast cancer, who were undergoing adjuvant AI therapy for at least 1 year. The survey assessed relevant cancer‐related, treatment, social and comorbid factors, and FACT‐ES (V4). Minimum acceptable treatment benefit was denoted as a percentage decrease in cancer recurrence risk, and percentage increase in survival at 5 years. Medical oncologists (MOs) treating breast cancer across Canada were also surveyed. A total of 153 patients were surveyed; median age was 60, 51% had node‐negative disease, 89% had prior radiati... The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5250212 Wed, 21 Sep 2011 04:00:00 +0100 5250212 http://www.medworm.com/index.php?rid=5250210&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01159.x Abstract:  The current standard therapeutic option for early stage breast cancer (EBC) employs a multimodality treatment approach including conservative surgery, radiotherapy, chemotherapy, and hormone therapy. The most common adjuvant radiotherapeutic strategy consists of external beam radiation therapy (EBRT) delivered to the whole breast using 1.8–2 Gy fractions given five times a week, up to a total dose of 45–50 Gy over a period of 5 weeks. In recent years, altered schedules employing larger dose per fraction delivered in fewer treatment sessions over a shorter overall treatment time began to be explored. We herein present clinical data on accelerated hypofractionated adjuvant whole‐breast radiotherapy delivered on a daily basis for a total treatment time of 20 fractions... The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5250210 Wed, 21 Sep 2011 04:00:00 +0100 5250210 http://www.medworm.com/index.php?rid=5250209&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01162.x This study aimed to discuss the role of agents, such as steroids and methotrexate (MTX), in the treatment of patients with idiopathic granulomatous mastitis (IGM). Using Pubmed and Google Scholar data bases, a retrospective study was carried out on IGM cases treated with steroids and/or MTX between 1972 and 2010. Four IGM cases treated with MTX at our clinic were also summarized in this study. A total of 541 IGM cases since 1972, including ours, were retrospectively analyzed. Steroid treatment 5–85 mg was administered over 5 days–22 months to 112 patients aged 21–48 years. Recurrence occurred in 22 patients, steroid‐induced diabetes mellitus in 5 patients, no response to treatment was observed in 4 patients, in 2 patients, the mass decreased in size, and static disease was ... The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5250209 Wed, 21 Sep 2011 04:00:00 +0100 5250209 http://www.medworm.com/index.php?rid=5236710&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01154.x In this study, we present the imaging features of a series of 10 cases with proved diagnosis of granulomatous mastitis with emphasis on magnetic resonance (MR) findings. All those patients who were histologically proven to have GM of the breast were analyzed. Their files were reviewed and data recorded for demographic, clinical presentation and imaging appearances. The imaging features of the lesions by mammography, ultrasound, and magnetic resonance imaging were analyzed. Of the 305 patients who were surgically treated, 10 (3%) cases proved to have GM. All the patients were females with age ranging from 27 to 53 years (average 38 years and median age 36 years). Guided core biopsy was performed in all cases for confirmation of diagnosis followed by either excision biopsy (in five cas... The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5236710 Mon, 19 Sep 2011 04:00:00 +0100 5236710 http://www.medworm.com/index.php?rid=5236709&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01160.x Abstract:  The aim of this study was to investigate the role of diffusion imaging in the evaluation of response to neoadjuvant breast cancer treatment by correlating apparent diffusion coefficient (ADC) value changes with pathological response. From June 2007 to June 2009, all consecutive patients with histopathologically confirmed breast cancer undergoing neoadjuvant chemotherapy were enrolled. All patients underwent magnetic resonance imaging (MRI) (including diffusion sequence) before and after neoadjuvant treatment. The ADC values obtained using two different methods of region of interest (ROI) placement before and after treatment were compared with MRI response (assessed using RECIST 1.1 criteria) and pathological response (assessed using Mandard’s classification).Fifty‐one wome... The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5236709 Mon, 19 Sep 2011 04:00:00 +0100 5236709 http://www.medworm.com/index.php?rid=5313818&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01150.x Abstract:  Locally advanced breast cancer (LABC) is a disease that is heterogeneous in its presentation, potentially curable, and generally necessitating multidisciplinary management. Radiation therapy (RT) plays an important role in the management of LABC. The integration of radiation with surgery, chemotherapy, and sometimes breast reconstruction can be complex. The American College of Radiology Appropriateness Criteria Breast Committee aims to provide guidance for the management of a variety of LABC cases. The American College of Radiology Appropriateness Criteria is evidence‐based guidelines for specific clinical conditions that are reviewed every 2 years by a multidisciplinary expert panel. The guideline development and review include an extensive analysis of current medical lit... The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5313818 Mon, 12 Sep 2011 04:00:00 +0100 5313818 http://www.medworm.com/index.php?rid=5207776&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01152.x Abstract:  Our study was to compare the clarity with which calcifications are seen on conventional mammography (CM) with the same calcifications on digital breast tomosynthesis (DBT). We define clarity as the sharpness, contrast, and diagnostic quality by which the calcifications were depicted. In a HIPPA compliant Institutional Review Board approved study, 3,000 women volunteered to have both a screening mammogram and a DBT study. A total of 119 sequential cases with relevant calcifications (not clearly benign) were reviewed. Two board certified, dedicated, breast imaging radiologists reviewed the CM and DBT images in an unblinded paired comparison. Only the mediolateral oblique (MLO) projection was available for the DBT studies. The MLO and craniocaudal projections were reviewed using ... The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5207776 Mon, 12 Sep 2011 04:00:00 +0100 5207776 http://www.medworm.com/index.php?rid=5207775&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01155.x Abstract:  Preoperative localization is important to optimize the surgical treatment of breast lesions, especially in nonpalpable lesions. Radioactive seed localization (RSL) using iodine‐125 is a relatively new approach. To provide accurate guidance to surgery, it is important that the seeds do not migrate after placement. The aim of this study was to assess short‐term and long‐term seed migration after RSL of breast lesions. In 45 patients, 48 RSL procedures were performed under ultrasound or stereotactic guidance. In the first 12 patients, the lesion was localized with two markers: an iodine‐125 seed and a reference marker. In 33 patients, 36 RSL procedures were performed using a single iodine‐125 seed. All patients received control mammograms after seed placement and prior ... The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5207775 Mon, 12 Sep 2011 04:00:00 +0100 5207775 http://www.medworm.com/index.php?rid=5207774&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01156.x Abstract:  The aim of this study was to demonstrate convincing evidence that percutaneous breast biopsy may result in displacement of malignant cells that can initiate tumor growth at a separate anatomic site, other than the index lesion. Two patients with malignancy diagnosed by percutaneous breast biopsy were followed up with subsequent imaging. The observation of displaced cells initiating subsequent malignant growth was compared retrospectively with the previous year’s outcomes following percutaneous breast biopsy. Two cases of displaced malignant cells resulting in malignant growth at a separate site along the biopsy needle track were demonstrated by imaging. During the preceding year, 1644 biopsies with 298 malignant results were compared with the outcomes of these two patients, ... The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5207774 Mon, 12 Sep 2011 04:00:00 +0100 5207774 http://www.medworm.com/index.php?rid=5335023&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01171.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5335023 Thu, 01 Sep 2011 04:00:00 +0100 5335023 http://www.medworm.com/index.php?rid=5323608&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01177.x Abstract:  The study was to determine if breast cancer patients aged 65 and above could be given adjuvant chemotherapy safely while achieving an acceptable relative dose intensity of at least 85%. We identified all patients aged 65 and over who received adjuvant chemotherapy over the 10 year period, November 1999 to October 2009, and determined the proportion that achieved a relative dose intensity of at least 85% as well as the tolerability of their treatment. A total of 101 patients were identified, with a median age of 69 years (range 65–78).Of these, 25.7% of patients had at least one major comorbidity, 84.2% had a tumor size of 5 cm or less, 73.3% were node positive and 58.4% were hormone receptor positive. The chemotherapy regimens used were AC (Doxorubicin and Cyclophospha... The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5323608 Thu, 01 Sep 2011 04:00:00 +0100 5323608 http://www.medworm.com/index.php?rid=5296521&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01170.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5296521 Thu, 01 Sep 2011 04:00:00 +0100 5296521 http://www.medworm.com/index.php?rid=5260070&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01143.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5260070 Thu, 01 Sep 2011 04:00:00 +0100 5260070 http://www.medworm.com/index.php?rid=5250207&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01164.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5250207 Thu, 01 Sep 2011 04:00:00 +0100 5250207 http://www.medworm.com/index.php?rid=5236708&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01158.x Abstract:  We performed a retrospective study of 856 breast cancer patients in our hospital, to compare the therapeutic effect of pirarubicin with cyclophosphamide and 5‐fluorouracil (CPF) with the standard epirubicin‐based regimen (CEF) in adjuvant treatment of breast cancer. Patients were given cyclophosphamide and 5‐fluorouracil 500 mg/m2 each, and either pirarubicin 40 mg/m2 or epirubicin 75–100 mg/m2, every 3 weeks, six cycles. A total of 233 patients used CPF and 623 patients used CEF regimen. The clinical and pathologic characteristics were well balanced between the two groups. The median follow‐up time was 41 months, relapse‐free survival (RFS) and overall survival (OS) were similar in both groups, p = 0.561 and p = 0.783, respectively. No treatment�... The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5236708 Thu, 01 Sep 2011 04:00:00 +0100 5236708 http://www.medworm.com/index.php?rid=5207779&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01126.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5207779 Thu, 01 Sep 2011 04:00:00 +0100 5207779 http://www.medworm.com/index.php?rid=5207778&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01140.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5207778 Thu, 01 Sep 2011 04:00:00 +0100 5207778 http://www.medworm.com/index.php?rid=5207777&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01134.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5207777 Thu, 01 Sep 2011 04:00:00 +0100 5207777 http://www.medworm.com/index.php?rid=5207773&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01150.x Abstract:  Locally advanced breast cancer (LABC) is a disease that is heterogeneous in its presentation, potentially curable, and generally necessitating multidisciplinary management. Radiation therapy (RT) plays an important role in the management of LABC. The integration of radiation with surgery, chemotherapy, and sometimes breast reconstruction can be complex. The American College of Radiology Appropriateness Criteria Breast Committee aims to provide guidance for the management of a variety of LABC cases. The American College of Radiology Appropriateness Criteria is evidence‐based guidelines for specific clinical conditions that are reviewed every 2 years by a multidisciplinary expert panel. The guideline development and review include an extensive analysis of current medical lit... The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5207773 Thu, 01 Sep 2011 04:00:00 +0100 5207773 http://www.medworm.com/index.php?rid=5108869&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01127.x Abstract:  Seroma has long been listed as a complication of MammoSite brachytherapy. Palpable abnormalities are clinically apparent months after treatment and a vast majority of patients demonstrate seroma formation in radiologic studies. We embarked on this study to evaluate the actual sonographic incidence and eventual sonographic resolution, possible contributing factors, cosmesis, pain, and local control associated with seroma formation after MammoSite partial breast irradiation (PBI). We investigated 160 patients who underwent MammoSite PBI from 2002 to 2006 of whom 100 patients had serial sonographic information. Clinical and tumor variables, infection, pain, and cosmesis were investigated. Dosimetric data including volume of balloon, dose at balloon surface, and at skin were analy... The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5108869 Mon, 08 Aug 2011 23:00:00 +0100 5108869 http://www.medworm.com/index.php?rid=5108868&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01136.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5108868 Mon, 08 Aug 2011 23:00:00 +0100 5108868 http://www.medworm.com/index.php?rid=5108867&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01137.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5108867 Mon, 08 Aug 2011 23:00:00 +0100 5108867 http://www.medworm.com/index.php?rid=5108866&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01138.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5108866 Mon, 08 Aug 2011 23:00:00 +0100 5108866 http://www.medworm.com/index.php?rid=5108865&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01139.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5108865 Mon, 08 Aug 2011 23:00:00 +0100 5108865 http://www.medworm.com/index.php?rid=5108864&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01141.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5108864 Mon, 08 Aug 2011 23:00:00 +0100 5108864 http://www.medworm.com/index.php?rid=5108863&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01142.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5108863 Mon, 08 Aug 2011 23:00:00 +0100 5108863 http://www.medworm.com/index.php?rid=5108862&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01144.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5108862 Mon, 08 Aug 2011 23:00:00 +0100 5108862 http://www.medworm.com/index.php?rid=5108861&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01145.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5108861 Mon, 08 Aug 2011 23:00:00 +0100 5108861 http://www.medworm.com/index.php?rid=5063258&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01117.x Abstract:  Adenoid cystic carcinoma (ACC) is an uncommon type of breast cancer. There are limited data about its epidemiology, tumor characteristics, and outcomes. Using a large, population‐based data base, this study aimed to identify specific characteristics of patients with adenoid cystic breast cancer, investigate its natural history, and determine its long‐term prognosis. The California Cancer Registry, a population‐based registry, was reviewed from the years 1988 to 2006. The data were analyzed with relation to patient age, tumor size and stage, and overall survival. Relative cumulative actuarial survival was determined using the Berkson‐Gage life table method. A total of 244 cases of invasive adenoid cystic cancer were identified in women during this time period. The patie... The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5063258 Sun, 24 Jul 2011 23:00:00 +0100 5063258 http://www.medworm.com/index.php?rid=5063257&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01135.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5063257 Sun, 24 Jul 2011 23:00:00 +0100 5063257 http://www.medworm.com/index.php?rid=5030009&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01119.x The objective of this study was to define the prevalence and to identify risk factors associated with development of ONJ in a predominantly low socio‐economic population. Medical records of patients with a diagnosis of metastatic breast cancer with bone metastasis seen between 2002 and 2007 were reviewed. All patients received a minimum of four infusions of zolendronic acid. Data on demographics, insurance status, tobacco use, concurrent therapy, body mass index, and number of zolendronic acid infusions were analyzed. Of the 110 patient analyzed, 10 developed ONJ (9%) with the mean number of zolendronic acid infusions in patients with ONJ of 22.9 ± 17. ONJ was seen more frequently in Caucasian than in African Americans patients (15% versus 2%; p = 0.019). ONJ was associated with... The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5030009 Thu, 14 Jul 2011 23:00:00 +0100 5030009 http://www.medworm.com/index.php?rid=5030008&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01122.x This study examines the cardiac toxicity of irradiation in left‐ versus right‐sided patients with ductal carcinoma in situ (DCIS). The medical records of 129 patients with DCIS treated with breast conservation therapy (BCT) at the Moffitt Cancer Center from 1986 to 2002 were reviewed and data regarding subsequent breast cancer and cardiac events were recorded. There were 59 left‐sided and 70 right‐sided patients treated. Mean age was 55 years. At 8 years, there was no significant difference observed between right‐ and left‐sided breast cancer patients in the development of coronary artery disease, myocardial infarction, congestive heart failure, arrhythmia, valvular disease, cardiomyopathy, or cardiac‐related death. Among those patients with left‐sided breast cancer, 13... The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5030008 Thu, 14 Jul 2011 23:00:00 +0100 5030008 http://www.medworm.com/index.php?rid=5030007&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01125.x In conclusion, the 8‐gauge UMS procedure is a safe and potent therapeutic management with satisfactory cosmetic outcome for benign and high‐risk breast lesions, especially for bilateral, multiple, and nonpalpable ones. It is a reliable biopsy tool for suspected lesions as well. Eradication and maximal cosmesis can be achieved with few complications if the targeted lesion is limited to 30 mm. (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5030007 Thu, 14 Jul 2011 23:00:00 +0100 5030007 http://www.medworm.com/index.php?rid=5030006&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01128.x Abstract:  The aim of this study was to determine the role of vacuum‐assisted biopsy (VAB) in patients with ultrasound imaging‐histologic discordance during 16‐gauge core needle biopsy (CNB) and to compare VAB with vacuum‐assisted removal (VAR) in diagnostic accuracy in patients with ultrasound imaging‐histologic discordance. From January 2006 to October 2008, a consecutive biopsy was performed on 1532 lesions with ultrasound‐guided 16‐gauge CNB. Sixty two lesions were considered to be ultrasound imaging‐histologic discordant. Among the 62 lesions, 55 lesions underwent subsequent VAB or VAR, which made up our study population. Among the 55 cases, 22 underwent subsequent US‐guided VAR, and the other 33 lesions underwent subsequent US‐guided VAB. All malignant lesions a... The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5030006 Thu, 14 Jul 2011 23:00:00 +0100 5030006 http://www.medworm.com/index.php?rid=5030005&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01129.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5030005 Thu, 14 Jul 2011 23:00:00 +0100 5030005 http://www.medworm.com/index.php?rid=5030004&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01130.x We describe a technique that uses a needle attached to a high vacuum wound drainage system. We believe that this technique is aseptic, relatively cheap, and efficient. It can easily and safely be adopted in the outpatient setting. (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5030004 Thu, 14 Jul 2011 23:00:00 +0100 5030004 http://www.medworm.com/index.php?rid=5030003&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01131.x We present a unique case of a patient presenting with a breast mass and axillary lymphadenopathy, mimicking malignancy clinically and radiographically. Core needle biopsies of the breast and axillary lymph node showed histologic features concerning the lymphoma. However, excisional biopsy specimen demonstrated characteristic features of Rosai‐Dorfman disease. The disease recurred locally 6 months later in the same breast, 1 month later in the contralateral breast, and 11 month later in the subcutaneous tissue of left flank. A review of the literature of Rosai‐Dorfman disease involving the breast is also presented. (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5030003 Thu, 14 Jul 2011 23:00:00 +0100 5030003 http://www.medworm.com/index.php?rid=4998384&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01116.x Abstract:  Some patients with small (≤1.0 cm) node‐negative (T1a,bN0) invasive breast cancer (IBC) who undergo only local therapy experience recurrences. There is limited information on prognostic factors in these patients. We sought to identify prognostic factors associated with disease‐free survival (DFS) and overall survival (OS) in patients with T1a,bN0 IBC. Histologic sections from 273 T1a,bN0 IBC patients treated at M. D. Anderson Cancer Center (MDACC) between 1980 and 1999 were reviewed. Microscopic tumor size; multifocality; histologic type, grade of tumor; presence, type, grade of associated ductal carcinoma in situ (DCIS); presence of fibrocystic changes (FCC) with/without atypia; and lymphovascular invasion were identified. The Kaplan–Meier method was used to evaluat... The Breast Journal journals http://www.medworm.com/rss/comments.php?id=4998384 Mon, 04 Jul 2011 23:00:00 +0100 4998384 http://www.medworm.com/index.php?rid=4998383&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01120.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=4998383 Mon, 04 Jul 2011 23:00:00 +0100 4998383 http://www.medworm.com/index.php?rid=4998382&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01121.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=4998382 Mon, 04 Jul 2011 23:00:00 +0100 4998382 http://www.medworm.com/index.php?rid=4998381&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01123.x We report a case of a 93‐year‐old woman who was diagnosed with estrogen receptor (ER)‐positive, progesterone receptor‐positive, T2N0M0 (stage I) breast cancer (BC) at the age of 45. Twenty‐two years later, she was diagnosed with metastatic lesions to the lungs consistent with the breast primary. Her disease was stable on tamoxifen, anastrozole, and exemestane for 14 years. Subsequently, she was found to have metastatic lesions to thoracic spine as well as progressively increasing bilateral pleural effusions. At that time, she was deemed not to be a good candidate for chemotherapy and therapy was changed to fulvestrant. Two years later (38 years after initial diagnosis of BC), she was diagnosed with new metastatic liver lesions; although her pulmonary and bone metastases remai... The Breast Journal journals http://www.medworm.com/rss/comments.php?id=4998381 Mon, 04 Jul 2011 23:00:00 +0100 4998381 http://www.medworm.com/index.php?rid=5196066&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01151.x This study suggests that baseline QoL (in particular, the role function) provides useful prognostic information in breast cancer. (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5196066 Thu, 30 Jun 2011 23:00:00 +0100 5196066 http://www.medworm.com/index.php?rid=5175437&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01148.x Abstract:  National Comprehensive Cancer Network (NCCN) guidelines for female breast cancer treatment and surveillance are well established, but similar guidelines on male breast cancers are less recognized. As an NCCN institution, our objective was to examine practice patterns and follow‐up for male breast cancer compared to established guidelines for female patients. After Institutional Review Board approval, a prospective breast database from 1990 to 2009 was queried for male patients. Medical records were examined for clinico‐pathological factors and follow‐up. The 5‐year survival rates with 95% confidence intervals were estimated using Kaplan–Meier method and Greenwood formula. Of the 19,084 patients in the database, 73 (0.4%) were male patients; 62 had complete data. One ... The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5175437 Thu, 30 Jun 2011 23:00:00 +0100 5175437 http://www.medworm.com/index.php?rid=5131637&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01147.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5131637 Thu, 30 Jun 2011 23:00:00 +0100 5131637 http://www.medworm.com/index.php?rid=5108860&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01146.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5108860 Thu, 30 Jun 2011 23:00:00 +0100 5108860 http://www.medworm.com/index.php?rid=5063256&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01132.x Abstract:  Breast conservation is a safe and effective alternative to mastectomy for the majority of women with early‐stage breast cancer. Adjuvant radiation therapy lowers the risk of recurrence within the breast and also confers a survival benefit. Although acute side effects of radiation therapy are generally well tolerated; efforts are ongoing to minimize the long‐term side effects of radiation, most prominently atherosclerotic heart disease. Efforts to minimize radiation therapy are also underway. They include omitting treatment altogether in the elderly and using accelerated, hypofractionated whole‐breast irradiation, and accelerated partial‐breast irradiation. Several randomized studies are ongoing to determine the efficacy, safety, and appropriate patients for these short... The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5063256 Thu, 30 Jun 2011 23:00:00 +0100 5063256 http://www.medworm.com/index.php?rid=5030014&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01107.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5030014 Thu, 30 Jun 2011 23:00:00 +0100 5030014 http://www.medworm.com/index.php?rid=5030013&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01108.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5030013 Thu, 30 Jun 2011 23:00:00 +0100 5030013 http://www.medworm.com/index.php?rid=5030012&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01096.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5030012 Thu, 30 Jun 2011 23:00:00 +0100 5030012 http://www.medworm.com/index.php?rid=5030011&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01113.x This study confirms that the axillary recurrence rate after long‐term follow‐up of patients with a negative sentinel lymph node is very rare, provided that the selection criteria are judicious. (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5030011 Thu, 30 Jun 2011 23:00:00 +0100 5030011 http://www.medworm.com/index.php?rid=5030010&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01114.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5030010 Thu, 30 Jun 2011 23:00:00 +0100 5030010 http://www.medworm.com/index.php?rid=5030002&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01133.x The objective of this study was to measure departures from multiplicative effects of alcohol consumption and BRCA gene mutations. A cohort of French‐Canadian breast cancer patients was tested for BRCA gene mutations and completed a food frequency questionnaire. The case‐only odds ratio (COR) was calculated. A total of 857 women, including 10 BRCA1 and 33 BRCA2 mutation carriers, participated in the study. No significant interaction between alcohol consumption and BRCA1 mutations was detected, although the interaction with wine consumption suggested a sub‐multiplicative effect (COR = 0.38, 95% CI: 0.08–1.81). Consumption of alcohol other than wine interacted significantly with BRCA2 mutations (COR = 2.15, 95% CI: 1.03–4.49). Consumption of wine may protect against BRCA1‐... The Breast Journal journals http://www.medworm.com/rss/comments.php?id=5030002 Thu, 30 Jun 2011 23:00:00 +0100 5030002 http://www.medworm.com/index.php?rid=4936102&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01099.x Abstract:  The purpose of this study was to compare short‐term versus long‐term axillary drainage in women treated for lymph node positive breast cancer. A comparative cohort study on differences between short‐term or long‐term axillary drainage was performed. Primary outcome measures were seroma formation demanding aspiration and wound related complications. Secondary outcome measures were type of operation (modified radical mastectomy (MRM) or wide local excision with axillary lymph node dissection (ALND) or completing ALND after positive sentinel node), length of hospital stay, and visits to the emergency department and outpatient clinic. The short‐term drainage group consisted of 37 patients, and the long‐term drainage group of 40 patients. Short‐term drainage was assoc... The Breast Journal journals http://www.medworm.com/rss/comments.php?id=4936102 Thu, 16 Jun 2011 23:00:00 +0100 4936102 http://www.medworm.com/index.php?rid=4936101&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01109.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=4936101 Thu, 16 Jun 2011 23:00:00 +0100 4936101 http://www.medworm.com/index.php?rid=4936100&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01106.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=4936100 Thu, 16 Jun 2011 23:00:00 +0100 4936100 http://www.medworm.com/index.php?rid=4936103&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01103.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=4936103 Mon, 13 Jun 2011 23:00:00 +0100 4936103 http://www.medworm.com/index.php?rid=4903576&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01089.x Abstract:  Systemic treatments for women with breast cancer frequently induce urogenital symptoms that can negatively impact a women’s quality of life. Urogenital atrophy is frequently undiagnosed and untreated, particularly in breast cancer survivors. Symptoms of urogenital atrophy can usually be relieved with vaginal estrogen preparations, but risk of recurrence and safety is undefined in women with a history of breast cancer. Treatment with nonhormonal modalities including vaginal moisturizers or lubricants and lifestyle modification are the first lines of management. Low‐dose vaginal 17 β‐estradiol (vaginal estradiol tablets 10 μg or vaginal estradiol ring) can be considered for the treatment of symptomatic urogenital atrophy in women with a history of breast cancer after a... The Breast Journal journals http://www.medworm.com/rss/comments.php?id=4903576 Sun, 05 Jun 2011 23:00:00 +0100 4903576 http://www.medworm.com/index.php?rid=4903575&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01091.x This study assessed the prognostic value of the VNPI after integration of proliferative biomarkers (GGI and Ki‐67). DCIS samples were divided into three VNPI subgroups (low risk [score 4–6], intermediate risk [score 7–9], high risk [score 10–12]) based on nuclear grade ± necrosis, tumor size, margin width, and age. Nuclear grade was substituted by the genomic grade index (GGI) to generate the VNPI‐GGI and combined with the Ki‐67 to generate the VNPI‐Ki67. Disease‐free survival was calculated by Kaplan–Meier survival plots with log‐rank significance. Multiple regression analysis was carried out using Cox proportional hazard regression analysis. A total of 88 cases (median age 54 years) with representative tissue were identified out of 168 DCIS patients. Median fol... The Breast Journal journals http://www.medworm.com/rss/comments.php?id=4903575 Sun, 05 Jun 2011 23:00:00 +0100 4903575 http://www.medworm.com/index.php?rid=4903574&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01093.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=4903574 Sun, 05 Jun 2011 23:00:00 +0100 4903574 http://www.medworm.com/index.php?rid=4903573&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01094.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=4903573 Sun, 05 Jun 2011 23:00:00 +0100 4903573 http://www.medworm.com/index.php?rid=4903572&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01095.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=4903572 Sun, 05 Jun 2011 23:00:00 +0100 4903572 http://www.medworm.com/index.php?rid=4894626&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01112.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=4894626 Tue, 31 May 2011 23:00:00 +0100 4894626 http://www.medworm.com/index.php?rid=4873015&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01097.x Abstract:  Increasing breast specialization triggered a review of our surgical activity. All 10,000 elective inpatient and day case procedures between 1998 and 2008 were grouped into six categories: oncological, primary, secondary and revisional oncoplastic, and other breast and nonbreast procedures. Overall, surgical activity increased, with a rise in breast and a fall in nonbreast procedures, as a result of a changing caseload in each category (chi‐squared for linear trend = 55.24: p < 0.00001). These included increases in oncological procedures, secondary oncoplastic, and revisional oncoplastic procedures. Increased oncoplastic activity was associated with a reduction in other breast procedures (chi‐squared for linear trend = 04.94: p < 0.00001). The impact o... The Breast Journal journals http://www.medworm.com/rss/comments.php?id=4873015 Thu, 26 May 2011 23:00:00 +0100 4873015 http://www.medworm.com/index.php?rid=4873014&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01098.x Abstract:  As is the case in many developing nations, previous studies of breast cancer screening behavior in Malaysia have used relatively small samples that are not nationally representative, thereby limiting the generalizability of results. Therefore, this study uses nationally representative data from the Malaysia Non‐Communicable Disease Surveillance‐1 to investigate the role of socio‐economic status on breast cancer screening behavior in Malaysia, particularly differences in screening behaviour between ethnic groups. The decisions of 816 women above age 40 in Malaysia to screen for breast cancer using mammography, clinical breast exams (CBE), and breast self‐exams (BSE) are modeled using logistic regression. Results indicate that after adjusting for differences in age, educ... The Breast Journal journals http://www.medworm.com/rss/comments.php?id=4873014 Thu, 26 May 2011 23:00:00 +0100 4873014 http://www.medworm.com/index.php?rid=4873013&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01100.x Abstract:  To evaluate overall survival (OS), disease‐free survival (DFS), and local‐recurrence free survival (LRFS) rates in a subgroup of patients affected by breast cancer expressing a particular phenotype (estrogen receptor negative, progesterone receptor negative, and Human Epidermal Growth Factor receptor 2 negative) known as “triple negative” (TN). Data of 387 women affected by early breast cancer who underwent whole‐breast radiotherapy after conservative surgery with or without chemotherapy and/or hormone therapy between January 2002 and December 2008, in the Department of Radiotherapy at Regional Cancer Center, were retrospectively evaluated. Chi‐squared test was used to compare prognostic factors (age, histology, tumor size, nodal status, grading, and adjuvant thera... The Breast Journal journals http://www.medworm.com/rss/comments.php?id=4873013 Thu, 26 May 2011 23:00:00 +0100 4873013 http://www.medworm.com/index.php?rid=4873012&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01101.x This study analyzes the pattern of cardiac testing and the incidence of heart failure (HF) in women treated with adjuvant trastuzumab in a real‐world setting. De‐identified medical and pharmacy claims data for women <65 years of age who began trastuzumab therapy between January 1, 2007 and December 31, 2007 were obtained from an integrated database at Medco Health Solutions, Inc. Patients receiving trastuzumab for ≥90 days were assessed for compliance with standard LV testing, defined as testing at baseline, at 4‐month intervals, and at the end of trastuzumab therapy. Cardiac risk factors and HF were identified by ICD‐9‐CM diagnosis codes, by medical claims, and by pharmacy claims for drugs used to treat diabetes, hypercholesterolemia, or HF. A total of 631 women receive... The Breast Journal journals http://www.medworm.com/rss/comments.php?id=4873012 Thu, 26 May 2011 23:00:00 +0100 4873012 http://www.medworm.com/index.php?rid=4873011&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01102.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=4873011 Thu, 26 May 2011 23:00:00 +0100 4873011 http://www.medworm.com/index.php?rid=4998380&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01124.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=4998380 Sat, 30 Apr 2011 23:00:00 +0100 4998380 http://www.medworm.com/index.php?rid=4946254&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01090.x Abstract:  Chest wall irradiation is very common for mastectomy patients that have opted for immediate breast reconstruction. We reviewed a 6 year experience with tissue expander implant reconstruction with and without radiotherapy in 97 patients. All patients were evaluated with respect to aesthetic outcome, infection, implant exposure, capsular contracture, displacement and failure of the reconstruction; more than 50% of our irradiated patients resulted in a complication. The findings of this study demonstrate that the rate of complications and the rate of patients requiring corrective surgeries in irradiated patients is significant in early follow up. (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=4946254 Sat, 30 Apr 2011 23:00:00 +0100 4946254 http://www.medworm.com/index.php?rid=4936099&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01111.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=4936099 Sat, 30 Apr 2011 23:00:00 +0100 4936099 http://www.medworm.com/index.php?rid=4913136&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01110.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=4913136 Sat, 30 Apr 2011 23:00:00 +0100 4913136 http://www.medworm.com/index.php?rid=4903571&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01104.x Abstract:  Developmental breast asymmetry (DBA) can affect psychosocial well‐being in the young female. Correction of breast asymmetry may present a reconstructive challenge, especially in tuberous breasts. Fifty‐two cases of DBA treated between January 2002 and January 2006 were reviewed. Preoperative clinical assessment of the specific anatomical deformity, subsequent surgical treatment modalities, esthetic outcome, and patient’s satisfaction were evaluated. Surgical modalities used in our series include augmentation mammaplasty with or without tissue expansion, parenchymal scoring, nipple areola complex reduction, glanduloplasty techniques, mastopexy and reduction mammaplasty. The mean age of DBA presentation was 21 years; 69% (36/52) patients had tuberous breasts, of which 67... The Breast Journal journals http://www.medworm.com/rss/comments.php?id=4903571 Sat, 30 Apr 2011 23:00:00 +0100 4903571 http://www.medworm.com/index.php?rid=4894625&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01092.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=4894625 Sat, 30 Apr 2011 23:00:00 +0100 4894625 http://www.medworm.com/index.php?rid=4873010&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01105.x In this study, we use population‐level data from multiple years of the Surveillance, Epidemiology, End Results (SEER) database to further define patient, tumor, and geographic characteristics associated with immediate and early‐delayed breast reconstruction. Population level de‐identified data for the years 1998 to 2002 were extracted from the National Cancer Institute’s (NCI) SEER cancer database. All female patients who were treated with mastectomy for a diagnosis of ductal and/or lobular breast cancer (including Paget disease) were included. The primary end point of interest was odds of reconstruction. Multivariate analysis was performed to control for patient demographic and oncologic characteristics. A total of 52,249 patients met the inclusion criteria. Reconstruction was per... The Breast Journal journals http://www.medworm.com/rss/comments.php?id=4873010 Sat, 30 Apr 2011 23:00:00 +0100 4873010 http://www.medworm.com/index.php?rid=4781917&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01084.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=4781917 Sat, 30 Apr 2011 23:00:00 +0100 4781917 http://www.medworm.com/index.php?rid=4781916&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01078.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=4781916 Sat, 30 Apr 2011 23:00:00 +0100 4781916 http://www.medworm.com/index.php?rid=4781915&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01087.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=4781915 Sat, 30 Apr 2011 23:00:00 +0100 4781915 http://www.medworm.com/index.php?rid=4715193&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01085.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=4715193 Thu, 14 Apr 2011 23:00:00 +0100 4715193 http://www.medworm.com/index.php?rid=4715192&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01076.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=4715192 Thu, 14 Apr 2011 23:00:00 +0100 4715192 http://www.medworm.com/index.php?rid=4685689&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01074.x This study evaluates the adherence to a consensus protocol in unselected women aged 80 years and older in the Netherlands. Data were derived from the Dutch population‐based Cancer Registry held by the Comprehensive Cancer Centre East. In this study all female patients, 60 years and older, diagnosed with breast cancer TNM stage I–IIIa in the period 2001 until 2006 were selected. Applied treatment according to the Dutch guideline was compared for different age groups. Differences between age groups were evaluated using a chi‐square test. In total, 2336 breast cancer patients were studied. Treatment adherence was significantly lower for surgery, radiation therapy and systemic therapy in women aged 80 years and older, and all modalities were applied much less frequently, except for... The Breast Journal journals http://www.medworm.com/rss/comments.php?id=4685689 Thu, 07 Apr 2011 23:00:00 +0100 4685689 http://www.medworm.com/index.php?rid=4685688&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01075.x Abstract:  Breast magnetic resonance imaging (MRI) is routinely used as a problem‐solving tool, but its benefit for this indication remains unclear. The records of 3001 consecutive breast MR examinations between January 1, 2003 and June 6, 2007 were reviewed to identify all those performed for the clinical indication of problem solving. Details of clinical presentation, mammography and ultrasound (US) findings, follow‐up recommendations, and pathology outcomes were recorded. Benign versus malignant outcomes were determined by biopsy or 12 months of follow‐up imaging and linkage with the regional tumor registry. Problem solving was the clinical indication for 204 of 3001 (7%) of all examinations. Forty‐two of 204 examinations (21%) had suspicious or highly suspicious MRI assessm... The Breast Journal journals http://www.medworm.com/rss/comments.php?id=4685688 Thu, 07 Apr 2011 23:00:00 +0100 4685688 http://www.medworm.com/index.php?rid=4685687&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01080.x Abstract:  Gynecomastia is a benign enlargement of male breast glandular tissue. At least a third of males are affected at some time during their lifetime. Idiopathic causes exceed other etiologies and relate to an imbalance in the ratio of estrogen to androgen tissue levels or end‐organ responsiveness to these hormones. Assessment must include a thorough history and clinical examination, specific blood investigations and usually tissue sampling and/or breast imaging. Management consists of a combination of measures that may include simple reassurance, pharmacological manipulation, medical treatment or surgery. Hormone therapy may help to abort the acute proliferative phase of gynecomastia with a 30% response rate but should not be considered in chronic established cases. Surgical trea... The Breast Journal journals http://www.medworm.com/rss/comments.php?id=4685687 Thu, 07 Apr 2011 23:00:00 +0100 4685687 http://www.medworm.com/index.php?rid=4685686&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01081.x Abstract:  A 55‐year‐old woman underwent radical mastectomy and axillary node dissection because of an invasive ductal carcinoma with neuroendocrine features. Histologically, all 22 sampled lymph nodes had widespread cystic inclusions lined by a regular, serous‐type epithelium positive for cytokeratin‐7, WT‐1, CA125, and estrogen receptors. Papillary projections were found in the lumen of some cysts. The lesions were consistent with florid, papillary endosalpingiosis (FPE), a hitherto unreported condition in a supradiaphragmatic location. Metastases from papillary carcinomas of ovary, breast, or thyroid were excluded considering the lesion’s immunophenotype (negative for mammaglobin and TTF‐1) and the absence of both atypical features and a concurrent abdominal serous tumor... The Breast Journal journals http://www.medworm.com/rss/comments.php?id=4685686 Thu, 07 Apr 2011 23:00:00 +0100 4685686 http://www.medworm.com/index.php?rid=4659020&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01065.x In this study, factors associated with having a mammogram among healthy women of screening age in Bahcesehir county, a region in Istanbul, were investigated to assess the feasibility of organized breast cancer screening in Turkey. In this cross‐sectional study, 659 healthy women aged between 40 and 69 years were surveyed. A multiple‐choice questionnaire was used to obtain information regarding patient demographics, family history of cancer, and patient knowledge on mammographic screening. Factors associated with increased likelihood of having a mammogram included age older than 50 (OR = 1.75; 95% CI = 1.23–2.49), higher educational level (high school or university graduate; OR = 1.55; 95% CI = 1.07–2.25), and undergoing periodic gynecologic examinations (OR = ... The Breast Journal journals http://www.medworm.com/rss/comments.php?id=4659020 Wed, 30 Mar 2011 23:00:00 +0100 4659020 http://www.medworm.com/index.php?rid=4659019&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01072.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=4659019 Wed, 30 Mar 2011 23:00:00 +0100 4659019 http://www.medworm.com/index.php?rid=4659018&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01079.x Abstract:  Ablative breast cancer surgery still includes the routine excision of the nipple‐areola complex (NAC). Nipple‐sparing mastectomy (NSM) removes the breast tissue leaving no or little retroareolar ductal tissue but preserves the entire skin of the breast and the NAC. There is some consensus that NSM might be an oncologically safe option for patients with small and peripherally located tumors and probably for high‐risk patients with prophylactic mastectomy. Several studies demonstrated that NSM may be feasible even in patients with large centrally located tumors or multicentric invasive carcinoma. So far, no generally applicable indications for NSM have been defined because long‐term data are still limited. However, from our review of the literature obtained from a MEDLIN... The Breast Journal journals http://www.medworm.com/rss/comments.php?id=4659018 Wed, 30 Mar 2011 23:00:00 +0100 4659018 http://www.medworm.com/index.php?rid=4627467&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01066.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=4627467 Thu, 24 Mar 2011 00:00:00 +0100 4627467 http://www.medworm.com/index.php?rid=4627466&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01069.x Abstract:  The diagnosis of ductal carcinoma in situ (DCIS) using core biopsy does not ensure the absence of invasion on final excision. We performed a retrospective analysis of 255 patients with DCIS who had subsequent excision. Clinical, radiologic, and pathologic findings were correlated with risk of invasion and sentinel lymph node (SLN) metastasis. Of 255 patients with DCIS, 199 had definitive surgery and 52 (26%) had invasive ductal carcinoma (IDC) on final excision. Extent of abnormal microcalcification on mammography, and presence of a radiologic/palpable mass and solid type of DCIS were significantly associated with invasion on final excision. Sentinel lymph node biopsy was performed in 131 (65.8%) patients of whom 18 (13.4%) had metastasis. Size of IDC and extent of DCIS on fin... The Breast Journal journals http://www.medworm.com/rss/comments.php?id=4627466 Thu, 24 Mar 2011 00:00:00 +0100 4627466 http://www.medworm.com/index.php?rid=4593717&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01063.x This study is designed to determine whether the use of magnetic resonance imaging (MRI) leads to an increased number of unnecessary mastectomies in breast cancer patients in the community setting. This is a retrospective study of the records of 178 patients from the local offices of three community physicians. The medical records of patients over the age of 18 with breast cancer who underwent both MRI and mammogram imaging were reviewed. MRI detected more lesions than mammogram; however, these lesions were not cancerous. The lesions detected by mammogram correlated more with pathologic lesions. Of the 59 patients who underwent mastectomies, 78% had MRI and 22% did not have the imaging. Of the 100 patients who had both MRI and mammogram, 48% underwent lumpectomy and 46% had mastectomy. More... The Breast Journal journals http://www.medworm.com/rss/comments.php?id=4593717 Tue, 15 Mar 2011 00:00:00 +0100 4593717 http://www.medworm.com/index.php?rid=4593716&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01064.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=4593716 Tue, 15 Mar 2011 00:00:00 +0100 4593716 http://www.medworm.com/index.php?rid=4593715&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01067.x Abstract:  Recent progress with declines in mortality in some high‐income countries has obscured the fact that for the majority of women worldwide who are newly diagnosed, breast cancer is a neglected disease in the context of other numerically more frequent health problems. For this growing majority, it is also an orphan disease, in that detailed knowledge about tumor characteristics and relevant host biology necessary to provide even basic care is absent. With the possible exception of nutritional recommendations, current international cancer policy and planning initiatives are irrelevant to breast cancer. The progress that has occurred in high‐income countries has come at extraordinary fiscal expense and patient toxicity, which of themselves suggest nonrelevance to women and healt... The Breast Journal journals http://www.medworm.com/rss/comments.php?id=4593715 Tue, 15 Mar 2011 00:00:00 +0100 4593715 http://www.medworm.com/index.php?rid=4593713&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01068.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=4593713 Tue, 15 Mar 2011 00:00:00 +0100 4593713 http://www.medworm.com/index.php?rid=4759294&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01088.x We present the apparent BRCA1‐related, although mutation negative, breast and ovarian cancer patient who subsequently was confirmed to be TP53 c.817C>T (p.R273C) mutation carrier and discuss the importance of peri‐diagnostic oncogenetic TP53 testing in early breast cancer cases. Histopathology and genetic modifiers (MDM2 SNP309G; TP53 R72P, PIN3) data are also addressed. (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=4759294 Tue, 01 Mar 2011 00:00:00 +0100 4759294 http://www.medworm.com/index.php?rid=4715191&cid=s_31107_6_f&fid=31107&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1524-4741.2011.01083.x (Source: The Breast Journal) The Breast Journal journals http://www.medworm.com/rss/comments.php?id=4715191 Tue, 01 Mar 2011 00:00:00 +0100 4715191