MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'The Journal of Clinical Endocrinology and Metabolism' source. Wed, 08 Feb 2012 15:09:04 +0100 http://www.medworm.com/index.php?rid=5644404&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22278418%26dopt%3DAbstract Conclusions:Metformin markedly diminished growth stimulation by insulin and showed an additive antimitogenic effect to chemotherapeutics agents. Therefore, our results suggest this drug as adjuvant treatment for thyroid cancer in type 2 diabetic patients. PMID: 22278418 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5644404 Wed, 25 Jan 2012 05:00:00 +0100 5644404 http://www.medworm.com/index.php?rid=5644403&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22278419%26dopt%3DAbstract Conclusions:The antitumor and antiangiogenic activity of a new "cyclic amide" compound, CLM94, is very promising in ATC, opening the way to a future clinical evaluation. PMID: 22278419 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5644403 Wed, 25 Jan 2012 05:00:00 +0100 5644403 http://www.medworm.com/index.php?rid=5644402&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22278420%26dopt%3DAbstract Conclusions:TSH plays a key role in the development of clinically detectable thyroid cancer, and LT4 treatment reduces the risk of thyroid malignancy in patients with nodular thyroid disease. According to the guidelines of the main scientific societies, LT4 therapy is not currently recommended for the treatment of patients with nodular goiter. Even if the available data are not sufficient to advise LT4 treatment in all patients with nodular goiter with the aim of reducing the risk of papillary thyroid carcinoma, we propose that this indication should be reconsidered, taking into account recent evidence reported in the literature. PMID: 22278420 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5644402 Wed, 25 Jan 2012 05:00:00 +0100 5644402 http://www.medworm.com/index.php?rid=5644401&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22278421%26dopt%3DAbstract Conclusion:Adiponectin levels are positively correlated with insulin sensitivity in T1D patients. However, T1D patients have decreased insulin sensitivity compared with controls at every level of adiponectin, suggesting an important adaptive change of adiponectin set point. PMID: 22278421 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5644401 Wed, 25 Jan 2012 05:00:00 +0100 5644401 http://www.medworm.com/index.php?rid=5644400&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22278422%26dopt%3DAbstract Conclusion:We found that: 1) a significant number of patients with APA had somatic mutations of the KCNJ5 gene; 2) KCNJ5 mRNA levels were higher in the APA with KCNJ5 mutations; and 3) the expression of KCNJ5 mRNA was significantly higher in APA than cortisol-producing adenomas and pheochromocytomas. PMID: 22278422 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5644400 Wed, 25 Jan 2012 05:00:00 +0100 5644400 http://www.medworm.com/index.php?rid=5644399&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22278423%26dopt%3DAbstract Conclusions:We report long-term cure rates in excess of 70%. Mortality is increased in CD and may be higher in patients with persistent/recurrent disease compared to patients cured after initial treatment. PMID: 22278423 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5644399 Wed, 25 Jan 2012 05:00:00 +0100 5644399 http://www.medworm.com/index.php?rid=5644398&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22278424%26dopt%3DAbstract Conclusion:These data suggest that combination treatment with cabergoline and pegvisomant is more effective at reducing IGF-I levels than either cabergoline or pegvisomant monotherapy. PMID: 22278424 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5644398 Wed, 25 Jan 2012 05:00:00 +0100 5644398 http://www.medworm.com/index.php?rid=5644397&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22278425%26dopt%3DAbstract Conclusions:The hypercoagulable state in patients with CD, which is explained by both increased production of procoagulant factors and impaired fibrinolysis, is not reversible upon short-term biochemical remission after successful medical therapy. This may have implications for the duration of anticoagulant prophylaxis in patients with (cured) CD. PMID: 22278425 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5644397 Wed, 25 Jan 2012 05:00:00 +0100 5644397 http://www.medworm.com/index.php?rid=5644396&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22278426%26dopt%3DAbstract Conclusions:Adults with LCH have high serum OPG levels and low serum RANKL levels. In contrast with other disorders involving the skeleton, serum Dkk-1 levels are similar between LCH patients and controls. PMID: 22278426 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5644396 Wed, 25 Jan 2012 05:00:00 +0100 5644396 http://www.medworm.com/index.php?rid=5644395&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22278427%26dopt%3DAbstract Conclusions:We found no evidence that BMD loss, as detected during routine clinical monitoring, was a significant independent risk factor for major osteoporotic fractures. PMID: 22278427 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5644395 Wed, 25 Jan 2012 05:00:00 +0100 5644395 http://www.medworm.com/index.php?rid=5644394&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22278428%26dopt%3DAbstract Conclusion:HyEx60 offered the greatest improvements in acute and moderate-term glucose control in T2D. Intermittent exercise stimulated glucose disposal and improved after exercise insulin resistance, which was enhanced when exercise was combined with hypoxia (Hy5:5). The data suggest a use of hypoxic exercise in treatment of T2D. PMID: 22278428 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5644394 Wed, 25 Jan 2012 05:00:00 +0100 5644394 http://www.medworm.com/index.php?rid=5644393&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22278429%26dopt%3DAbstract Conclusions:Vitamin D deficiency was common in this contemporary U.K. cohort. Despite some overlap, there are differences in potential confounding structures for associations of 25(OH)D(3) and 25(OH)D(2) with health outcomes. These should be accounted for in future studies. PMID: 22278429 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5644393 Wed, 25 Jan 2012 05:00:00 +0100 5644393 http://www.medworm.com/index.php?rid=5644392&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22278430%26dopt%3DAbstract Conclusion:The long-term follow-up of our JMC patient has provided insight on therapeutic strategies to control hypercalciuria, on the potential effects of alendronate on FGF23 levels, and on the lack of detectable cardiovascular disease at young adulthood after prolonged exposure to hypercalcemia. PMID: 22278430 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5644392 Wed, 25 Jan 2012 05:00:00 +0100 5644392 http://www.medworm.com/index.php?rid=5644391&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22278431%26dopt%3DAbstract Authors: van Wijk JP, Broekhuizen-de Gast HS, Smits AJ, Schipper ME, Zelissen PM Abstract Abstract Not Available. PMID: 22278431 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5644391 Wed, 25 Jan 2012 05:00:00 +0100 5644391 http://www.medworm.com/index.php?rid=5644390&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22278432%26dopt%3DAbstract Conclusions:These findings point toward the possibility of using the expression levels of these genes in blood cells as markers of metabolic status and can potentially provide an early warning of a future disorder. PMID: 22278432 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5644390 Wed, 25 Jan 2012 05:00:00 +0100 5644390 http://www.medworm.com/index.php?rid=5644389&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22278433%26dopt%3DAbstract Conclusion:Homozygosity for the GHR-exon3 full-length allele and/or the -202C-IGFBP3 allele are associated with less favorable short- and long-term growth outcomes after rhGH treatment in patients with TS. PMID: 22278433 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5644389 Wed, 25 Jan 2012 05:00:00 +0100 5644389 http://www.medworm.com/index.php?rid=5644388&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22278434%26dopt%3DAbstract Conclusions:IP is currently the best assay to detect clinically relevant NALP5 Ab. Presence of NALP5 Ab in only one patient with IH who also had AIRE gene mutation suggests that these Ab are exceptionally rare in IH (0.69%) and, when present, occur in context of the autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy syndrome. PMID: 22278434 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5644388 Wed, 25 Jan 2012 05:00:00 +0100 5644388 http://www.medworm.com/index.php?rid=5627378&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22259052%26dopt%3DAbstract Conclusions:Adipose tissue accumulating in the dorsocervical area in HIV lipodystrophy does not appear to be classical BAT. However, DIO2 expression is increased in DSAT among patients with HIV lipodystrophy, particularly those with increased visceral adiposity, and is positively associated with energy expenditure. PMID: 22259052 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5627378 Wed, 18 Jan 2012 05:00:00 +0100 5627378 http://www.medworm.com/index.php?rid=5627377&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22259053%26dopt%3DAbstract Conclusion:Young women with AN have low cold-activated BAT, which may be due to impaired BAT thermogenesis. Young women with BAT have higher BMD and lower Pref-1 compared with women without BAT, suggesting that BAT may be involved in the regulation of stem cell differentiation into the bone lineage at the expense of adipogenesis. PMID: 22259053 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5627377 Wed, 18 Jan 2012 05:00:00 +0100 5627377 http://www.medworm.com/index.php?rid=5627376&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22259054%26dopt%3DAbstract Authors: Bongiovanni M, Suriano S, Bolli M, Cattaneo F, Fasolini F, Giovanella L Abstract Abstract Not Available. PMID: 22259054 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5627376 Wed, 18 Jan 2012 05:00:00 +0100 5627376 http://www.medworm.com/index.php?rid=5627375&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22259055%26dopt%3DAbstract Conclusions:(18)F-FDOPA PET is a useful complementary imaging study to detect neuroendocrine tumors in patients with VHL undergoing surveillance, especially in those suspected to have adrenal pheochromocytoma or unusual ectopic locations. PMID: 22259055 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5627375 Wed, 18 Jan 2012 05:00:00 +0100 5627375 http://www.medworm.com/index.php?rid=5627374&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22259056%26dopt%3DAbstract Conclusion:WGEP analysis revealed that not all cAMP activation is the same: adrenal lesions harboring PRKAR1A or GNAS mutations share the downstream activation of certain oncogenic signals (such as MAPK and some cell cycle genes) but differ substantially in their effects on others. PMID: 22259056 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5627374 Wed, 18 Jan 2012 05:00:00 +0100 5627374 http://www.medworm.com/index.php?rid=5627373&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22259057%26dopt%3DAbstract Conclusion:In healthy, growing children, increased collagen in adipose tissue is associated with decreased fat cell size and BMI z score and increased M2+ phenotype macrophages, suggesting dynamic interaction between ECM remodeling and immune cells even at an early age. PMID: 22259057 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5627373 Wed, 18 Jan 2012 05:00:00 +0100 5627373 http://www.medworm.com/index.php?rid=5627372&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22259058%26dopt%3DAbstract Conclusions:Heart failure is associated with a 30% increase in major fractures that is independent of traditional risk factors and BMD, and it also identifies a high-risk population that may benefit from increased screening and treatment for osteoporosis. PMID: 22259058 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5627372 Wed, 18 Jan 2012 05:00:00 +0100 5627372 http://www.medworm.com/index.php?rid=5627371&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22259059%26dopt%3DAbstract Conclusion:Loss of KLF9 coregulation of endometrial stromal PGR-responsive gene networks may underlie progesterone resistance in endometriosis. PMID: 22259059 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5627371 Wed, 18 Jan 2012 05:00:00 +0100 5627371 http://www.medworm.com/index.php?rid=5627370&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22259060%26dopt%3DAbstract Conclusion:This study indicated that using salivary cortisol measurements for the CRH test could be a reliable method for evaluating the hypothalamic-pituitary-adrenal axis in VLBWI with gestational age of less than 29 wk. PMID: 22259060 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5627370 Wed, 18 Jan 2012 05:00:00 +0100 5627370 http://www.medworm.com/index.php?rid=5627369&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22259061%26dopt%3DAbstract Authors: Machens A, Kotzerke J, Dralle H Abstract Abstract Not Available. PMID: 22259061 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5627369 Wed, 18 Jan 2012 05:00:00 +0100 5627369 http://www.medworm.com/index.php?rid=5627368&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22259062%26dopt%3DAbstract Conclusions:These data indicate that FLNA is crucial for D2R expression and signaling in lactotrophs, suggesting that the impaired response to DA may be related to the reduction of FLNA expression in DA-resistant prolactinomas. PMID: 22259062 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5627368 Wed, 18 Jan 2012 05:00:00 +0100 5627368 http://www.medworm.com/index.php?rid=5627367&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22259063%26dopt%3DAbstract Conclusions:This is the first report that ghrelin suppresses the secretion of LH and FSH in women. These findings resemble those in male and female animals and in men. PMID: 22259063 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5627367 Wed, 18 Jan 2012 05:00:00 +0100 5627367 http://www.medworm.com/index.php?rid=5627366&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22259064%26dopt%3DAbstract Conclusions:These results provide evidence that acute sleep loss enhances hedonic stimulus processing in the brain underlying the drive to consume food, independent of plasma glucose levels. These findings highlight a potentially important mechanism contributing to the growing levels of obesity in Western society. PMID: 22259064 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5627366 Wed, 18 Jan 2012 05:00:00 +0100 5627366 http://www.medworm.com/index.php?rid=5627365&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22259065%26dopt%3DAbstract Conclusion:Postnatal E2 and P replacement may have potential in improving neurodevelopmental outcome in ELBW infants. Larger trials are needed to test this new hypothesis. PMID: 22259065 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5627365 Wed, 18 Jan 2012 05:00:00 +0100 5627365 http://www.medworm.com/index.php?rid=5627364&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22259066%26dopt%3DAbstract Conclusion:We here report for the first time that both antigens, TPO and Tg, are recognized by CD8-positive T cells and are involved in the thyroid destruction process leading to clinical disease manifestation. PMID: 22259066 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5627364 Wed, 18 Jan 2012 05:00:00 +0100 5627364 http://www.medworm.com/index.php?rid=5627363&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22259067%26dopt%3DAbstract Conclusions:These findings identify TRH as a potent, novel neuroendocrine stimulator of mitochondrial activity and biogenesis in human epidermal keratinocytes in situ. Thus, human epidermis offers an excellent model for dissecting neuroendocrine controls of human mitochondrial biology under physiologically relevant conditions and for exploring corresponding clinical applications. PMID: 22259067 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5627363 Wed, 18 Jan 2012 05:00:00 +0100 5627363 http://www.medworm.com/index.php?rid=5607351&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22238382%26dopt%3DAbstract Conclusions:Mortality rates were increased in this population of adults treated as children with recombinant GH, particularly in those who had received the highest doses. Specific effects were detected in terms of death due to bone tumors or cerebral hemorrhage but not for all cancers. These results highlight the need for additional studies of long-term mortality and morbidity after GH treatment in childhood. PMID: 22238382 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5607351 Wed, 11 Jan 2012 05:00:00 +0100 5607351 http://www.medworm.com/index.php?rid=5607350&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22238383%26dopt%3DAbstract Authors: Baron R, Hesse E Abstract Osteoporosis is defined as low bone mineral density associated with skeletal fractures secondary to minimal or no trauma, most often involving the spine, the hip, and the forearm. The decrease in bone mineral density is the consequence of an unbalanced bone remodeling process, with higher bone resorption than bone formation. Osteoporosis affects predominantly postmenopausal women, but also older men. This chronic disease represents a considerable medical and socioeconomic burden for modern societies. The therapeutic options for the treatment of osteoporosis have so far comprised mostly antiresorptive drugs, in particular bisphosphonates and more recently denosumab, but also calcitonin and, for women, estrogens or selective estrogen receptor modula... The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5607350 Wed, 11 Jan 2012 05:00:00 +0100 5607350 http://www.medworm.com/index.php?rid=5607349&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22238384%26dopt%3DAbstract Conclusions:In GO, mast cells, monocytes, and macrophages may activate orbital fibroblasts via secretion of especially PDGF-AB and PDGF-BB. Preclinical studies with whole orbital tissue cultures show that blocking PDGF-B chain containing isoforms can be a promising treatment for GO. PMID: 22238384 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5607349 Wed, 11 Jan 2012 05:00:00 +0100 5607349 http://www.medworm.com/index.php?rid=5607348&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22238385%26dopt%3DAbstract Conclusions:Muscle mitochondrial oxidative phosphorylation is impaired in patients with congenital lipodystrophy, a paradigmatic example of primary adipose tissue dysfunction. This finding suggests that changes in mitochondrial oxidative phosphorylation in skeletal muscle could, at least in some circumstances, be a secondary consequence of adipose tissue failure. These data corroborate accumulating evidence that mitochondrial dysfunction can be a consequence of insulin-resistant states rather than a primary defect. Nevertheless, impaired mitochondrial fat oxidation is likely to accelerate ectopic fat accumulation and worsen insulin resistance. PMID: 22238385 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5607348 Wed, 11 Jan 2012 05:00:00 +0100 5607348 http://www.medworm.com/index.php?rid=5607347&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22238386%26dopt%3DAbstract Conclusion:A change in 25-OHD assays has a significant impact on results, patient classification, and treatment recommendations. Such variability cannot be ignored when deriving and applying vitamin D guidelines. It also renders universal assay standardization a pressing call. PMID: 22238386 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5607347 Wed, 11 Jan 2012 05:00:00 +0100 5607347 http://www.medworm.com/index.php?rid=5607346&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22238387%26dopt%3DAbstract Authors: Faje AT, Tritos NA Abstract Abstract Not Available. PMID: 22238387 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5607346 Wed, 11 Jan 2012 05:00:00 +0100 5607346 http://www.medworm.com/index.php?rid=5607345&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22238388%26dopt%3DAbstract Conclusions:We confirm that TNF-α is associated with IGT and T2D in a large, multiethnic population, independent of measures of adiposity. Adjusted values of TNF-α, as well as relationships between TNF-α and variables related to T2D, varied by ethnicity. Increased TNF-α levels were predominantly associated with insulin resistance but not with primary defects in β-cell function. PMID: 22238388 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5607345 Wed, 11 Jan 2012 05:00:00 +0100 5607345 http://www.medworm.com/index.php?rid=5607344&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22238389%26dopt%3DAbstract Conclusion:The UBB are not the only source of calcitonin-producing cells in humans. Interactions between calcitonin-producing and thyroid follicular cells occur earlier than previously accepted. PMID: 22238389 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5607344 Wed, 11 Jan 2012 05:00:00 +0100 5607344 http://www.medworm.com/index.php?rid=5607343&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22238390%26dopt%3DAbstract Authors: Chernausek SD Abstract Intrauterine growth restriction (IUGR) is prevalent worldwide and affects children and adults in multiple ways. These include predisposition to type 2 diabetes mellitus, the metabolic syndrome, cardiovascular disease, persistent reduction in stature, and possibly changes in the pattern of puberty. A review of recent literature confirms that the metabolic effects of being born small for gestational age are evident in the very young, persist with age, and are amplified by adiposity. Furthermore, the pattern of growth in the first few years of life has a significant bearing on a person's later health, with those that show increasing weight gain being at the greatest risk for future metabolic dysfunction. Treatment with exogenous human GH is used to impr... The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5607343 Wed, 11 Jan 2012 05:00:00 +0100 5607343 http://www.medworm.com/index.php?rid=5607342&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22238391%26dopt%3DAbstract Conclusion:Older people at high cardiovascular risk with low or very high TSH along with normal free T(4) appear at increased risk of incident heart failure. PMID: 22238391 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5607342 Wed, 11 Jan 2012 05:00:00 +0100 5607342 http://www.medworm.com/index.php?rid=5607341&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22238392%26dopt%3DAbstract Conclusions:Dapagliflozin reduces TBW, predominantly by reducing FM, VAT and SAT in T2DM inadequately controlled with metformin. PMID: 22238392 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5607341 Wed, 11 Jan 2012 05:00:00 +0100 5607341 http://www.medworm.com/index.php?rid=5607340&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22238393%26dopt%3DAbstract Conclusions:In these cohorts, the majority of deaths (76%) were caused by accidents or suicides. Importantly, none of the patients died from cancer or from a cardiovascular disease. PMID: 22238393 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5607340 Wed, 11 Jan 2012 05:00:00 +0100 5607340 http://www.medworm.com/index.php?rid=5607339&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22238394%26dopt%3DAbstract Authors: McGeoch SC, Olson S, Krukowski ZH, Bevan JS Abstract Abstract Not Available. PMID: 22238394 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5607339 Wed, 11 Jan 2012 05:00:00 +0100 5607339 http://www.medworm.com/index.php?rid=5607338&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22238395%26dopt%3DAbstract Conclusion:Overall, these results suggest that although some aspects of the neuropsychological profile of TS may be influenced by epigenetic factors, the sociocognitive phenotype associated with the disorder is not modulated by genomic imprinting. PMID: 22238395 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5607338 Wed, 11 Jan 2012 05:00:00 +0100 5607338 http://www.medworm.com/index.php?rid=5607337&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22238396%26dopt%3DAbstract Conclusions:A single measurement of thyroid function did not predict total or cause-specific mortality in this cohort. These data support neither a beneficial nor a detrimental effect of subclinical thyroid dysfunction in older men.Summary:Subclinical thyroid dysfunction is not associated with an increased risk of all-cause or CV mortality in older men. PMID: 22238396 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5607337 Wed, 11 Jan 2012 05:00:00 +0100 5607337 http://www.medworm.com/index.php?rid=5607336&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22238397%26dopt%3DAbstract Conclusions:Subclinical thyroid disease affects hepatic VLDL-TG but not VLDL-apoB-100 metabolism: subclinical hypothyroidism increases, whereas subclinical hyperthyroidism decreases, hepatic VLDL-TG secretion rate compared with the euthyroid state. Plasma VLDL-TG concentration is greater in subclinical hypothyroid than euthyroid and hyperthyroid subjects, due to greater secretion of large, TG-rich VLDL particles from the liver. PMID: 22238397 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5607336 Wed, 11 Jan 2012 05:00:00 +0100 5607336 http://www.medworm.com/index.php?rid=5607335&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22238398%26dopt%3DAbstract Conclusion:When glucose is infused into the small intestine at equal rates in healthy young and older subjects, GLP-1 and GIP responses are comparable, indicating that impaired incretin secretion does not account for age-related glucose intolerance. PMID: 22238398 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5607335 Wed, 11 Jan 2012 05:00:00 +0100 5607335 http://www.medworm.com/index.php?rid=5607334&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22238399%26dopt%3DAbstract Conclusions:Exposure of human fetal testes to DBP is unlikely to impair testosterone production as it does in rats. This has important safety and regulatory implications. PMID: 22238399 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5607334 Wed, 11 Jan 2012 05:00:00 +0100 5607334 http://www.medworm.com/index.php?rid=5607333&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22238400%26dopt%3DAbstract Conclusions:The Minidose outpatient ablation protocol is effective and diagnostically useful in low-risk DTC. PMID: 22238400 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5607333 Wed, 11 Jan 2012 05:00:00 +0100 5607333 http://www.medworm.com/index.php?rid=5607332&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22238401%26dopt%3DAbstract Conclusions:Despite steady research progress, mechanisms underlying the resistance to fat loss once obesity is established remain incompletely understood. Breakthroughs in this area may be required for the development of effective new obesity prevention and treatment strategies. PMID: 22238401 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5607332 Wed, 11 Jan 2012 05:00:00 +0100 5607332 http://www.medworm.com/index.php?rid=5607331&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22238402%26dopt%3DAbstract Conclusion:These findings demonstrate a key role for ErbB1 in adipogenesis and suggest that lower ErbB1 protein abundance may lead to adipose tissue dysfunction. PMID: 22238402 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5607331 Wed, 11 Jan 2012 05:00:00 +0100 5607331 http://www.medworm.com/index.php?rid=5607330&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22238403%26dopt%3DAbstract Conclusion:WT1 expression is down-regulated in ovPCOS endometrium during the window of implantation. Androgens regulate the expression of WT1 and its targets during endometrial decidualization. The altered balance between WT1 and AR in the endometrium of PCOS patients may jeopardize the success of decidualization and endometrial receptivity. PMID: 22238403 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5607330 Wed, 11 Jan 2012 05:00:00 +0100 5607330 http://www.medworm.com/index.php?rid=5607329&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22238404%26dopt%3DAbstract Conclusions:Atypical CD increases the need for T(4). The effect was reversed by GFD or by increasing T(4) dose. Malabsorption of T(4) may provide the opportunity to detect CD that was overlooked until the patients were put under T(4) therapy. PMID: 22238404 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5607329 Wed, 11 Jan 2012 05:00:00 +0100 5607329 http://www.medworm.com/index.php?rid=5607328&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22238405%26dopt%3DAbstract Conclusions:CD patients are at increased risk of PHPT, but the absolute risk is small, and the excess risk disappeared after more than 5 yr of follow-up. PMID: 22238405 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5607328 Wed, 11 Jan 2012 05:00:00 +0100 5607328 http://www.medworm.com/index.php?rid=5607327&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22238406%26dopt%3DAbstract Conclusions:This study of the first nonconsanguineous patient with LHX3 mutations demonstrates the pleiotropic roles of LHX3 during development and its full involvement in the complex disease phenotype. Isolated limitation of head rotation may exist in heterozygous carriers and would result from a dominant-negative effect. These data allowed the first prenatal diagnoses of this severe condition to be performed. PMID: 22238406 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5607327 Wed, 11 Jan 2012 05:00:00 +0100 5607327 http://www.medworm.com/index.php?rid=5607326&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22238407%26dopt%3DAbstract Conclusions:u18OHF, u18oxoF, and s18OHB measurements in patients with a positive aldosterone/plasma renin activity ratio correlate with confirmatory tests and adrenal vein sampling in PA patients. If verified, these steroid assays would refine the diagnostic workup for PA. PMID: 22238407 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5607326 Wed, 11 Jan 2012 05:00:00 +0100 5607326 http://www.medworm.com/index.php?rid=5607325&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22238408%26dopt%3DAbstract Authors: Herman WH, Cohen RM Abstract Hemoglobin A1c (HbA1c) is widely used as an index of mean glycemia in diabetes, as a measure of risk for the development of diabetic complications, and as a measure of the quality of diabetes care. In 2010, the American Diabetes Association recommended that HbA1c tests, performed in a laboratory using a method certified by the National Glycohemoglobin Standardization Program, be used for the diagnosis of diabetes. Although HbA1c has a number of advantages compared to traditional glucose criteria, it has a number of disadvantages. Hemoglobinopathies, thalassemia syndromes, factors that impact red blood cell survival and red blood cell age, uremia, hyperbilirubinemia, and iron deficiency may alter HbA1c test results as a measure of average glycem... The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5607325 Wed, 11 Jan 2012 05:00:00 +0100 5607325 http://www.medworm.com/index.php?rid=5607324&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22238409%26dopt%3DAbstract Authors: Lee R, Hyer J, Chowdhury H, Teimory M Abstract Abstract Not Available. PMID: 22238409 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5607324 Wed, 11 Jan 2012 05:00:00 +0100 5607324 http://www.medworm.com/index.php?rid=5580324&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22223763%26dopt%3DAbstract Authors: McCrimmon RJ Abstract Hypoglycemia remains a major clinical issue in the management of people with type 1 and type 2 diabetes. Research in basic science is only beginning to unravel the mechanisms that: 1) underpin the detection of hypoglycemia and initiation of a counterregulatory defense response; and 2) contribute to the development of defective counterregulation in both type 1 and type 2 diabetes, particularly after prior exposure to repeated hypoglycemia. In animal studies, the central nervous system has emerged as key to these processes. However, bench-based research needs to be translated through studies in human subjects as a first step to the future development of clinical intervention. This Update reviews studies published in the last 2 yr that examined the centr... The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5580324 Sun, 01 Jan 2012 05:00:00 +0100 5580324 http://www.medworm.com/index.php?rid=5580323&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22223764%26dopt%3DAbstract Authors: Gordon CM, Pitts SA Abstract It is essential to develop contraceptive counseling skills given the potential complications associated with an unplanned pregnancy, especially for adolescents. Multiple factors must be considered when reviewing contraceptive options with an adolescent: maturity, finances, access to care and prescriptions, confidentiality, medical risks and benefits, and contraindications to use of certain hormonal agents. Many adolescents will be concerned about the possibility of weight gain or the development of acne associated with the use of certain contraceptive agents. They are usually unaware of the risks of thrombosis, stroke, or adverse bone health effects. Providers must be able to speak to these issues using an evidence-based approach. PMID: 222... The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5580323 Sun, 01 Jan 2012 05:00:00 +0100 5580323 http://www.medworm.com/index.php?rid=5580322&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22223765%26dopt%3DAbstract Conclusions: Hyperglycemia is a common, serious, and costly health care problem in hospitalized patients. Observational and randomized controlled studies indicate that improvement in glycemic control results in lower rates of hospital complications in general medicine and surgery patients. Implementing a standardized sc insulin order set promoting the use of scheduled basal and nutritional insulin therapy is a key intervention in the inpatient management of diabetes. We provide recommendations for practical, achievable, and safe glycemic targets and describe protocols, procedures, and system improvements required to facilitate the achievement of glycemic goals in patients with hyperglycemia and diabetes admitted in non-critical care settings. PMID: 22223765 [PubMed - in process] (Sourc... The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5580322 Sun, 01 Jan 2012 05:00:00 +0100 5580322 http://www.medworm.com/index.php?rid=5580321&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22223766%26dopt%3DAbstract Authors: Silye R, Rieger R, Topakian R, Dunzinger A, Aigner RM, Pichler R PMID: 22223766 [PubMed - in process] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5580321 Sun, 01 Jan 2012 05:00:00 +0100 5580321 http://www.medworm.com/index.php?rid=5580320&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22223767%26dopt%3DAbstract Authors: Fuqua JS, Sims EK PMID: 22223767 [PubMed - in process] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5580320 Sun, 01 Jan 2012 05:00:00 +0100 5580320 http://www.medworm.com/index.php?rid=5580319&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22223768%26dopt%3DAbstract Authors: Cizza G, Rother KI PMID: 22223768 [PubMed - in process] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5580319 Sun, 01 Jan 2012 05:00:00 +0100 5580319 http://www.medworm.com/index.php?rid=5580318&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22223769%26dopt%3DAbstract Authors: Sperling MA PMID: 22223769 [PubMed - in process] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5580318 Sun, 01 Jan 2012 05:00:00 +0100 5580318 http://www.medworm.com/index.php?rid=5580317&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22223770%26dopt%3DAbstract Authors: PMID: 22223770 [PubMed - in process] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5580317 Sun, 01 Jan 2012 05:00:00 +0100 5580317 http://www.medworm.com/index.php?rid=5580316&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22223771%26dopt%3DAbstract Authors: PMID: 22223771 [PubMed - in process] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5580316 Sun, 01 Jan 2012 05:00:00 +0100 5580316 http://www.medworm.com/index.php?rid=5580315&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22223772%26dopt%3DAbstract Authors: PMID: 22223772 [PubMed - in process] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5580315 Sun, 01 Jan 2012 05:00:00 +0100 5580315 http://www.medworm.com/index.php?rid=5580314&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22223773%26dopt%3DAbstract Authors: PMID: 22223773 [PubMed - in process] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5580314 Sun, 01 Jan 2012 05:00:00 +0100 5580314 http://www.medworm.com/index.php?rid=5580313&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22223774%26dopt%3DAbstract Authors: PMID: 22223774 [PubMed - in process] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5580313 Sun, 01 Jan 2012 05:00:00 +0100 5580313 http://www.medworm.com/index.php?rid=5580312&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22223775%26dopt%3DAbstract Authors: Korytkowski M, McDonnell ME, Umpierrez GE, Zonszein J PMID: 22223775 [PubMed - in process] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5580312 Sun, 01 Jan 2012 05:00:00 +0100 5580312 http://www.medworm.com/index.php?rid=5552957&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22205709%26dopt%3DAbstract Conclusions:This was the first demonstration of proteasomal degradation of RIα protein variants leading to PRKAR1A haploinsufficiency and CNC, adding protein surveillance to NMD in the cellular mechanisms overseeing RIα synthesis. In agreement with the molecular data, CNC patients bearing PRKAR1A defects that extend the open reading frame did not have a different phenotype, although this has to be confirmed in a larger number of patients. PMID: 22205709 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5552957 Wed, 28 Dec 2011 05:00:00 +0100 5552957 http://www.medworm.com/index.php?rid=5552956&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22205710%26dopt%3DAbstract Conclusions:We conclude that LADA and type 1 diabetes are phenotypically indistinguishable in this predominantly minority population with a mean duration of glutamic acid decarboxylase antibody-positive diabetes of about 8 yr. PMID: 22205710 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5552956 Wed, 28 Dec 2011 05:00:00 +0100 5552956 http://www.medworm.com/index.php?rid=5552955&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22205711%26dopt%3DAbstract Authors: Bhavnani BR, Stanczyk FZ Abstract Abstract Not Available. PMID: 22205711 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5552955 Wed, 28 Dec 2011 05:00:00 +0100 5552955 http://www.medworm.com/index.php?rid=5552954&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22205712%26dopt%3DAbstract Authors: Pearce EN Abstract Thyroid hormone has multiple effects on the regulation of lipid synthesis, absorption, and metabolism. Studies consistently demonstrate elevated levels of serum total cholesterol, low-density lipoprotein cholesterol (LDL-C), apolipoprotein B, lipoprotein(a), and possibly triglycerides in individuals with overt hypothyroidism, all of which are reversible with levothyroxine therapy. Although it is estimated that 1 to 11% of all patients with dyslipidemia have subclinical hypothyroidism, the effects of subclinical hypothyroidism on serum lipid values are less clear. Apolipoprotein B levels may be increased in patients with subclinical hypothyroidism. Although some studies have demonstrated that total cholesterol and LDL-C levels are elevated in patients wit... The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5552954 Wed, 28 Dec 2011 05:00:00 +0100 5552954 http://www.medworm.com/index.php?rid=5552953&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22205713%26dopt%3DAbstract Conclusion:There is a positive relationship between serum TSH levels and hypertension in children and adolescents, suggesting that subclinical hypothyroidism is associated with an increased risk of hypertension. PMID: 22205713 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5552953 Wed, 28 Dec 2011 05:00:00 +0100 5552953 http://www.medworm.com/index.php?rid=5539120&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22188740%26dopt%3DAbstract Conclusion:The suboptimal concentrations of serum 25(OH)D found in adults receiving GCS are inadequate for prevention and management of glucocorticoid-induced osteoporosis. Recommendations for vitamin D supplementation should be adjusted accordingly. PMID: 22188740 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539120 Wed, 21 Dec 2011 05:00:00 +0100 5539120 http://www.medworm.com/index.php?rid=5539119&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22188741%26dopt%3DAbstract Conclusions:Androgen receptor genotypes encoding moderate functional variation may influence cryptorchidism risk, particularly among boys with bilateral nondescent or congenital hernia, and may explain in part the elevated risk of testicular seminoma experienced by ex-cryptorchid boys. Mechanistic research is warranted to examine both classical and nonclassical mechanisms through which androgens may influence risk of cryptorchidism and related conditions. PMID: 22188741 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539119 Wed, 21 Dec 2011 05:00:00 +0100 5539119 http://www.medworm.com/index.php?rid=5539118&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22188742%26dopt%3DAbstract Conclusions:We provide first evidence that humans homozygous for the PER3 5/5 allele are particularly sensitive to blue-enriched light, as indexed by the suppression of endogenous melatonin and waking theta activity. Light sensitivity in humans may be modulated by a clock gene polymorphism implicated in the sleep-wake regulation. PMID: 22188742 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539118 Wed, 21 Dec 2011 05:00:00 +0100 5539118 http://www.medworm.com/index.php?rid=5539117&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22188743%26dopt%3DAbstract Conclusions:Endocrine disorders were common after pediatric cancers. Endocrinologists should be aware of national guidelines, anticipate referral of pediatric cancer survivors, and participate in further research to optimize screening for and treatment of endocrine effects of cancer therapy. PMID: 22188743 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539117 Wed, 21 Dec 2011 05:00:00 +0100 5539117 http://www.medworm.com/index.php?rid=5539116&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22188744%26dopt%3DAbstract Conclusion:Maternal serum FABP4 levels are elevated before the clinical onset of preeclampsia, and this increase occurs independently of maternal body mass index. PMID: 22188744 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539116 Wed, 21 Dec 2011 05:00:00 +0100 5539116 http://www.medworm.com/index.php?rid=5539115&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22188745%26dopt%3DAbstract Conclusion:The current study discovered an increased frequency of Tfh cells in AITD patients, which implies that this cell subset might play an important role in the pathogenesis of AITD. PMID: 22188745 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539115 Wed, 21 Dec 2011 05:00:00 +0100 5539115 http://www.medworm.com/index.php?rid=5539114&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22188746%26dopt%3DAbstract Conclusion:Our study indicates that the majority of male patients with PWS have primary testicular failure, which becomes apparent after onset of puberty. Hypogonadotropic hypogonadism did not appear to be the main reason of hypogonadism in most boys. PMID: 22188746 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539114 Wed, 21 Dec 2011 05:00:00 +0100 5539114 http://www.medworm.com/index.php?rid=5539122&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22174422%26dopt%3DAbstract Authors: Rosenfeld RG, Cohen P, Robison LL, Bercu BB, Clayton P, Hoffman AR, Radovick S, Saenger P, Savage MO, Wit JM Abstract Abstract Not Available. PMID: 22174422 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539122 Thu, 15 Dec 2011 05:00:00 +0100 5539122 http://www.medworm.com/index.php?rid=5539121&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22174423%26dopt%3DAbstract Conclusions:Insulin resistance accounts for a large and significant proportion of the excess risk of diabetes in Mexican-Americans. Matsuda index is better than HOMA-IR for both explaining the ethnic difference and predicting diabetes. PMID: 22174423 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539121 Thu, 15 Dec 2011 05:00:00 +0100 5539121 http://www.medworm.com/index.php?rid=5539146&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22170706%26dopt%3DAbstract Conclusions:The physiological increase in β-endorphin levels during exercise is associated with the attenuation of counterregulation during subsequent hypoglycemia. PMID: 22170706 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539146 Wed, 14 Dec 2011 05:00:00 +0100 5539146 http://www.medworm.com/index.php?rid=5539145&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22170707%26dopt%3DAbstract Conclusions:Adult subjects with lifetime congenital untreated IGHD present reduced β-cell function, no evidence of IR, and higher frequency of impaired glucose tolerance. PMID: 22170707 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539145 Wed, 14 Dec 2011 05:00:00 +0100 5539145 http://www.medworm.com/index.php?rid=5539144&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22170708%26dopt%3DAbstract Conclusion:CYP17A1 inhibition with abiraterone acetate is characterized by significant suppression of androgen and cortisol synthesis. The latter is associated with a rise in ACTH that causes raised mineralocorticoids, leading to side effects and incomplete 17α-hydroxylase inhibition. Concomitant inhibition of 17,20-lyase results in diversion of 17-hydroxyprogesterone metabolites toward androgen synthesis via the backdoor pathway. Addition of dexamethasone reverses toxicity and could further suppress androgens by preventing a rise in substrates of backdoor androgen synthesis. PMID: 22170708 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539144 Wed, 14 Dec 2011 05:00:00 +0100 5539144 http://www.medworm.com/index.php?rid=5539143&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22170709%26dopt%3DAbstract Conclusions:High-dose Ca test is a potent and well-tolerated procedure that can be applied worldwide at a low cost. Reference ranges for Ca sCT levels in different groups of patients and CT thresholds to diagnose CCH/MTC have been identified. PMID: 22170709 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539143 Wed, 14 Dec 2011 05:00:00 +0100 5539143 http://www.medworm.com/index.php?rid=5539142&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22170710%26dopt%3DAbstract Conclusion:We have identified the first human CYB5A missense mutation as the cause of isolated 17,20 lyase deficiency in three individuals with 46,XY DSD. Detailed review of previously reported cases with apparently isolated 17,20 lyase deficiency due to mutant CYP17A1 and POR reveals impaired 17α-hydroxylase activity as assessed by steroid metabolome analysis and short cosyntropin testing. This suggests that truly isolated 17,20 lyase deficiency is observed only in individuals with inactivating CYB5A mutations. PMID: 22170710 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539142 Wed, 14 Dec 2011 05:00:00 +0100 5539142 http://www.medworm.com/index.php?rid=5539141&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22170711%26dopt%3DAbstract Conclusions:In our large community-based sample, greater adiposity was associated with higher circulating growth factor levels in general. Additional studies are warranted to confirm the stronger association of VAT and periaortic fat with HGF in women and to examine its potential contribution to the sex-related differences in cardiometabolic risk. PMID: 22170711 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539141 Wed, 14 Dec 2011 05:00:00 +0100 5539141 http://www.medworm.com/index.php?rid=5539140&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22170712%26dopt%3DAbstract Conclusions:AMHo and FSHo are representative of distinctively different components of FOR, likely influenced by different ovarian FMR1 genotypes and subgenotypes. PMID: 22170712 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539140 Wed, 14 Dec 2011 05:00:00 +0100 5539140 http://www.medworm.com/index.php?rid=5539139&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22170713%26dopt%3DAbstract Discussion: Before surgery, plasma glucose reduction was greater in the IGC group than in the CGC and GIK groups (P < 0.001 for both). IGC patients had higher MPC (P < 0.01) and cycling myocytes (P < 0.01), as well as less oxidized (P < 0.01) and senescent MPC (P < 0.01) in peri-infarcted specimens compared with both CGC and GIK patients. Tight glycemic control, by reducing senescent MPC, may increase regenerative potential of the ischemic myocardium. PMID: 22170713 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539139 Wed, 14 Dec 2011 05:00:00 +0100 5539139 http://www.medworm.com/index.php?rid=5539138&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22170714%26dopt%3DAbstract Conclusions:These data demonstrate that clonal BRAF(V600E) is a rare occurrence in PTC, although frequently this cancer consists of a mixture of tumor cells with wild-type and mutant BRAF. These results suggest that BRAF mutation in PTC is a later subclonal event, its intratumoral heterogeneity may hamper the efficacy of targeted pharmacotherapy, and its association with a more aggressive disease should be reevaluated. PMID: 22170714 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539138 Wed, 14 Dec 2011 05:00:00 +0100 5539138 http://www.medworm.com/index.php?rid=5539137&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22170715%26dopt%3DAbstract Conclusions:To our knowledge, this is the first study to use qHTS of a large drug library to identify candidate drugs for anticancer therapy. Our results indicate such a screening approach can lead to the discovery of novel agents in different therapeutic categories and drugs with nonclassic chemotherapy mode of action. Our approach could lead to drug repurposing and accelerate clinical trials of compounds with well-established pharmacokinetics and toxicity profiles. PMID: 22170715 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539137 Wed, 14 Dec 2011 05:00:00 +0100 5539137 http://www.medworm.com/index.php?rid=5539136&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22170716%26dopt%3DAbstract Conclusions:In hypopituitary women, raloxifene at therapeutic doses significantly attenuated the beneficial effects of GH on body composition compared with 17β-estradiol. Raloxifene has no metabolic advantage over 17β-estradiol during GH replacement. PMID: 22170716 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539136 Wed, 14 Dec 2011 05:00:00 +0100 5539136 http://www.medworm.com/index.php?rid=5539135&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22170717%26dopt%3DAbstract Conclusions:Our findings indicate a need to revise the Chompret criteria. However, in younger adults (<40 yr old) with ACC, screening for TP53 germline mutations may be justified. PMID: 22170717 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539135 Wed, 14 Dec 2011 05:00:00 +0100 5539135 http://www.medworm.com/index.php?rid=5539134&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22170718%26dopt%3DAbstract Conclusions:The current study reveals that UGT2B15 and UGT2B17 are differentially regulated during prostate cancer progression. Furthermore, this study also identifies the UGT2B15 gene as a negatively regulated target gene in castration-resistant prostate cancer and lymph node metastases. PMID: 22170718 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539134 Wed, 14 Dec 2011 05:00:00 +0100 5539134 http://www.medworm.com/index.php?rid=5539133&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22170719%26dopt%3DAbstract Conclusions:CFTR regulates ovarian estrogen biosynthesis by amplifying the FSH-stimulated signal via the nuclear soluble adenylyl cyclase. The present findings suggest that defective CFTR-dependent regulation of estrogen production may underlie the ovarian disorders seen in CF and PCOS. PMID: 22170719 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539133 Wed, 14 Dec 2011 05:00:00 +0100 5539133 http://www.medworm.com/index.php?rid=5539132&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22170720%26dopt%3DAbstract Conclusions:These observations demonstrate that BK(Ca) channels: 1) are expressed in endometrial cells; 2) affect embryo implantation by mediating endometrial receptive factors; and 3) alter the activity of NF-κB and homeostasis of Ca(2+) in the human endometrial cells. PMID: 22170720 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539132 Wed, 14 Dec 2011 05:00:00 +0100 5539132 http://www.medworm.com/index.php?rid=5539131&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22170721%26dopt%3DAbstract Conclusion:Gestational hypothyroidism is more common than generally acknowledged. Testing is not common, and test selection is variable. There is a low rate of postpartum follow-up. PMID: 22170721 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539131 Wed, 14 Dec 2011 05:00:00 +0100 5539131 http://www.medworm.com/index.php?rid=5539130&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22170722%26dopt%3DAbstract Conclusions:As a screening tool, the SI-derived T-score obtained from the Achilles QUS device for a postmenopausal woman or man that is less than -1.25 and -1.30, respectively, may indicate an increased risk of osteoporotic fractures and should be further evaluated by central DXA. PMID: 22170722 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539130 Wed, 14 Dec 2011 05:00:00 +0100 5539130 http://www.medworm.com/index.php?rid=5539129&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22170723%26dopt%3DAbstract Conclusion:Metreleptin replacement therapy is equally effective in FPLD patients with both SH and MH in reducing serum and hepatic triglyceride levels, but did not improve hyperglycemia. PMID: 22170723 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539129 Wed, 14 Dec 2011 05:00:00 +0100 5539129 http://www.medworm.com/index.php?rid=5539128&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22170724%26dopt%3DAbstract Conclusion:We describe the first kindred with a germline SDHD pathogenic mutation, inherited PGL, and acromegaly due to a GH-producing pituitary adenoma. SDHD loss of heterozygosity, down-regulation of protein in the GH-secreting adenoma, and decreased SDH enzymatic activity supports SDHD's involvement in the pituitary tumor formation in this patient. Older cases of multiple PGL and PHEO and pituitary tumors in the literature support a possible association between SDH defects and pituitary tumorigenesis. PMID: 22170724 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539128 Wed, 14 Dec 2011 05:00:00 +0100 5539128 http://www.medworm.com/index.php?rid=5539127&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22170725%26dopt%3DAbstract Conclusions:The elevated ratios of pdiol to the Δ(4) and Δ(5) pathway metabolites as well as the higher androsterone to etiocholanolone ratio in patients with 21-OHD indicate postnatal activity of the backdoor pathway with maximum activity during early infancy. Our data provide new insights into the pathophysiology of androgen biosynthesis of 21-OHD. PMID: 22170725 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539127 Wed, 14 Dec 2011 05:00:00 +0100 5539127 http://www.medworm.com/index.php?rid=5539126&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22170726%26dopt%3DAbstract Conclusions:Radionuclide therapy with [(131)I]IMTO is a promising treatment option for selected patients with ACC, deserving evaluation in prospective clinical trials. PMID: 22170726 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539126 Wed, 14 Dec 2011 05:00:00 +0100 5539126 http://www.medworm.com/index.php?rid=5539125&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22170727%26dopt%3DAbstract Conclusions:Improvements observed in insulin regulation of free fatty acid and glucose metabolism with rimonabant treatment in humans was not greater than that predicted by weight loss alone. PMID: 22170727 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539125 Wed, 14 Dec 2011 05:00:00 +0100 5539125 http://www.medworm.com/index.php?rid=5539124&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22170728%26dopt%3DAbstract Conclusion:TPIT mutations are responsible for two thirds of neonatal-onset complete IAD but can not be detected in partial or late-onset IAD. PMID: 22170728 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539124 Wed, 14 Dec 2011 05:00:00 +0100 5539124 http://www.medworm.com/index.php?rid=5539123&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22170729%26dopt%3DAbstract Conclusions:The combination of somatostatin analogs and everolimus in therapeutic trials offers a promising treatment option for neuroendocrine tumors. PMID: 22170729 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539123 Wed, 14 Dec 2011 05:00:00 +0100 5539123 http://www.medworm.com/index.php?rid=5539166&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22162463%26dopt%3DAbstract Conclusions:Retraining obese adolescents to eat more slowly has a significant impact on the gastrointestinal hormone response to a carbohydrate load, suggesting that externally modifiable eating behaviors actually regulate the hormonal response to food. PMID: 22162463 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539166 Wed, 07 Dec 2011 05:00:00 +0100 5539166 http://www.medworm.com/index.php?rid=5539165&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22162464%26dopt%3DAbstract Conclusions:Our data support a role of BA in human energy metabolism and in thyroid hormone control. Even though no convincing response to BA was demonstrated in TSHoma and TαT1 cells, the TSH decrease after a nutritional challenge suggests an interaction of BA on the set point of the thyroid axis. PMID: 22162464 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539165 Wed, 07 Dec 2011 05:00:00 +0100 5539165 http://www.medworm.com/index.php?rid=5539164&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22162465%26dopt%3DAbstract Conclusions:The reduction of EE cells is a specific and important early event in the pathogenesis of APECED with GI dysfunction. We propose a diagnostic algorithm integrating clinics, genetics and immunohistology. PMID: 22162465 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539164 Wed, 07 Dec 2011 05:00:00 +0100 5539164 http://www.medworm.com/index.php?rid=5539163&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22162466%26dopt%3DAbstract Conclusions:The time of thyroidectomy in GC with negative CT could be personalized and safely planned when stimulated CT becomes positive, independent of the type of RET mutation and patient's age. In this series, a basal CT below 60 pg/ml was always associated to an intrathyroidal localization of MTC. PMID: 22162466 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539163 Wed, 07 Dec 2011 05:00:00 +0100 5539163 http://www.medworm.com/index.php?rid=5539162&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22162467%26dopt%3DAbstract Conclusion:Relative to their height, PWS patients not treated with GH had normal axial and appendicular BMD, muscle size, and muscle-bone relationships. PMID: 22162467 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539162 Wed, 07 Dec 2011 05:00:00 +0100 5539162 http://www.medworm.com/index.php?rid=5539161&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22162468%26dopt%3DAbstract Conclusion:This is the first study to establish age-specific reference ranges for liquid chromatography-tandem mass spectrometry-measured TT and AD and calculated free T concentrations based on quantile regression analyses, accurately accounting for the observed low concentration range and the strong age dependency of these sex hormones in women. PMID: 22162468 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539161 Wed, 07 Dec 2011 05:00:00 +0100 5539161 http://www.medworm.com/index.php?rid=5539160&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22162469%26dopt%3DAbstract Conclusions:SRS appears to be less sensitive than conventional imaging at detecting the full extent of metastatic disease in children and adolescents with hereditary MTC. SRS incompletely identified sites of tumor and failed to visualize small sites of tumor or liver and lung metastases, and it has a limited role in the evaluation of metastatic disease in pediatric MTC patients. PMID: 22162469 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539160 Wed, 07 Dec 2011 05:00:00 +0100 5539160 http://www.medworm.com/index.php?rid=5539159&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22162470%26dopt%3DAbstract Conclusions:We characterize the coordinated and time-dependent processes that occur in human adipose tissue during the early phase of weight gain in healthy subjects and identify pathways representing potential targets in pathologies of adipose development, including obesity. PMID: 22162470 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539159 Wed, 07 Dec 2011 05:00:00 +0100 5539159 http://www.medworm.com/index.php?rid=5539158&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22162471%26dopt%3DAbstract Conclusion:Verbal and visual memory is worse in CS patients than controls, even after biochemical cure. HV was decreased only in those whose memory scores were below normative cutoff values. PMID: 22162471 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539158 Wed, 07 Dec 2011 05:00:00 +0100 5539158 http://www.medworm.com/index.php?rid=5539157&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22162472%26dopt%3DAbstract Conclusions:This study did not confirm a better response of d3GHR to PEG-V treatment in acromegaly. Other studies are needed to determine whether deviation from Hardy-Weinberg equilibrium may indicate an association of d3GHR genotype with poor response to usual treatments. PMID: 22162472 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539157 Wed, 07 Dec 2011 05:00:00 +0100 5539157 http://www.medworm.com/index.php?rid=5539156&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22162473%26dopt%3DAbstract Conclusions:EP3 is the primary receptor subtype that mediates PGE(2) induced contractility in human pregnant myometrium at term and represents a possible therapeutic target. PMID: 22162473 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539156 Wed, 07 Dec 2011 05:00:00 +0100 5539156 http://www.medworm.com/index.php?rid=5539155&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22162474%26dopt%3DAbstract Conclusions:Circulating galanin levels at birth are not affected by GDM and IUGR, providing no evidence for alternations in hypothalamic galanin expression and secretion in humans, as they were previously documented in experimental models. This fact precludes the use of plasma galanin as an early indicator for the development of obesity and metabolic syndrome in this high-risk population. PMID: 22162474 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539155 Wed, 07 Dec 2011 05:00:00 +0100 5539155 http://www.medworm.com/index.php?rid=5539154&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22162475%26dopt%3DAbstract Conclusions:Androgen deprivation therapy remains the treatment of choice for metastatic prostate cancer; however, it is not without its adverse effects, and most men with advanced disease eventually develop castration resistance. Newer compounds that more specifically and effectively target androgen and androgen receptor signaling in prostate cancer cells may provide more long-lasting remissions in advanced disease. PMID: 22162475 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539154 Wed, 07 Dec 2011 05:00:00 +0100 5539154 http://www.medworm.com/index.php?rid=5539153&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22162476%26dopt%3DAbstract Conclusions:The current limited clinical experience suggests potential beneficial cognitive effects of intranasal insulin. Analyses provide clinical considerations for future research aimed at elucidating whether intranasal insulin may be used to improve cognitive functions. PMID: 22162476 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539153 Wed, 07 Dec 2011 05:00:00 +0100 5539153 http://www.medworm.com/index.php?rid=5539152&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22162477%26dopt%3DAbstract Conclusions:We confirm correlations of maternal thyroid parameters with gestational age during the first half of pregnancy and show a substantially increased risk of (subclinical) hypothyroidism in TPOAb-positive mothers. A substantial part of the mothers had a TSH level above 2.5 mU/liter, underlining the importance of using population-specific reference ranges. Maternal and cord thyroid parameters were positively correlated, the exact biological basis of which remains to be determined. PMID: 22162477 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539152 Wed, 07 Dec 2011 05:00:00 +0100 5539152 http://www.medworm.com/index.php?rid=5539151&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22162478%26dopt%3DAbstract Conclusions:We report clinical, biochemical, and genetic findings in a large PORD cohort and show that MLPA is a useful addition to POR mutation analysis. Homozygosity for the most frequent mutation in Caucasians, p.A287P, allows for prediction of genital phenotype and moderate malformations. Adrenal insufficiency is frequent, easily overlooked, but readily detected by cosyntropin testing. PMID: 22162478 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539151 Wed, 07 Dec 2011 05:00:00 +0100 5539151 http://www.medworm.com/index.php?rid=5539150&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22162479%26dopt%3DAbstract Conclusion:Our findings suggest that the anomalies in melatonin profiles of SMS patients might be due to a disturbance of the molecular circadian clockwork. PMID: 22162479 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539150 Wed, 07 Dec 2011 05:00:00 +0100 5539150 http://www.medworm.com/index.php?rid=5539149&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22162480%26dopt%3DAbstract Conclusions:The results have several possible explanations including a phosphorylation-dependent repressor of HAS2 transcript accumulation, exclusively in the orbit. The difference in control of HAS2 expression allows the activation of one of the mechanisms underlying GO, adipogenesis, to be linked biologically with the second, HA overproduction. PMID: 22162480 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539149 Wed, 07 Dec 2011 05:00:00 +0100 5539149 http://www.medworm.com/index.php?rid=5539148&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22162481%26dopt%3DAbstract Conclusion:LB03002 at doses of 0.5 mg/kg/wk and 0.7 mg/kg/wk was shown to be effective and safe with once-weekly dosing in GH-deficient children, and 0.5 mg/kg/wk LB03002 was chosen as the optimal dose for long-term assessment. PMID: 22162481 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539148 Wed, 07 Dec 2011 05:00:00 +0100 5539148 http://www.medworm.com/index.php?rid=5539147&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22162482%26dopt%3DAbstract Conclusions:ZnT8A are useful additional risk markers in relatives at low genetic risk of diabetes and older individuals, but they add relatively little in younger populations because of the precise prediction possible with current autoantibody combinations. PMID: 22162482 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539147 Wed, 07 Dec 2011 05:00:00 +0100 5539147 http://www.medworm.com/index.php?rid=5539180&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22143827%26dopt%3DAbstract Authors: PMID: 22143827 [PubMed - in process] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539180 Thu, 01 Dec 2011 05:00:00 +0100 5539180 http://www.medworm.com/index.php?rid=5539179&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22143828%26dopt%3DAbstract This article is based on an invited lecture entitled "Year-in-the-Adrenal: A Clinical Perspective," presented at the 92nd Annual Meeting of The Endocrine Society in Boston, Massachusetts, on June 7, 2011. The objective was to provide clinicians with a summary of key, clinically important advances in the field of adrenal disorders over the past 18 months. Paper selection was based on a comprehensive survey of all adrenal articles published in major endocrinology and high-impact general medical journals between December 2009 and May 2011. Participants in the selection process included 15 endocrinologists with expertise in adrenal disorders. The articles highlighted were those that: 1) constitute novel discoveries that may improve the understanding of pathophysiology; 2) address important cli... The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539179 Thu, 01 Dec 2011 05:00:00 +0100 5539179 http://www.medworm.com/index.php?rid=5539178&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22143829%26dopt%3DAbstract Authors: Buchanan TA, Page KA Abstract The diagnosis of gestational diabetes mellitus (GDM) identifies patients with a pancreatic β-cell defect. In some patients, the defect is transient or stable, but in most it is progressive, imparting a high risk of diabetes for at least a decade after the index pregnancy. The β-cell defects in GDM can result from many causes, including genetic variants typical of monogenic forms of diabetes and autoimmunity typical of evolving type 1 diabetes. No specific disease-modifying therapies are available for those patients. The majority of women with GDM have clinical characteristics indicating a risk for type 2 diabetes (T2D). Available evidence indicates that T2D can be prevented or delayed by intensive lifestyle modification and by medications, p... The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539178 Thu, 01 Dec 2011 05:00:00 +0100 5539178 http://www.medworm.com/index.php?rid=5539177&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22143830%26dopt%3DAbstract Authors: Chong WH, Yavuz S, Patel SM, Chen CC, Collins MT PMID: 22143830 [PubMed - in process] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539177 Thu, 01 Dec 2011 05:00:00 +0100 5539177 http://www.medworm.com/index.php?rid=5539176&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22143831%26dopt%3DAbstract Authors: Nakamura K, Ogata M, Ando T, Usa T, Kawakami A PMID: 22143831 [PubMed - in process] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539176 Thu, 01 Dec 2011 05:00:00 +0100 5539176 http://www.medworm.com/index.php?rid=5539175&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22143832%26dopt%3DAbstract Authors: Robertson RP PMID: 22143832 [PubMed - in process] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539175 Thu, 01 Dec 2011 05:00:00 +0100 5539175 http://www.medworm.com/index.php?rid=5539174&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22143833%26dopt%3DAbstract Authors: Fauser BC, Bouchard P PMID: 22143833 [PubMed - in process] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539174 Thu, 01 Dec 2011 05:00:00 +0100 5539174 http://www.medworm.com/index.php?rid=5539173&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22143834%26dopt%3DAbstract Authors: PMID: 22143834 [PubMed - in process] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539173 Thu, 01 Dec 2011 05:00:00 +0100 5539173 http://www.medworm.com/index.php?rid=5539172&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22143835%26dopt%3DAbstract Authors: PMID: 22143835 [PubMed - in process] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539172 Thu, 01 Dec 2011 05:00:00 +0100 5539172 http://www.medworm.com/index.php?rid=5539171&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22143836%26dopt%3DAbstract Authors: PMID: 22143836 [PubMed - in process] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539171 Thu, 01 Dec 2011 05:00:00 +0100 5539171 http://www.medworm.com/index.php?rid=5539170&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22143837%26dopt%3DAbstract Authors: PMID: 22143837 [PubMed - in process] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539170 Thu, 01 Dec 2011 05:00:00 +0100 5539170 http://www.medworm.com/index.php?rid=5539169&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22143838%26dopt%3DAbstract Authors: PMID: 22143838 [PubMed - in process] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539169 Thu, 01 Dec 2011 05:00:00 +0100 5539169 http://www.medworm.com/index.php?rid=5539168&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22143839%26dopt%3DAbstract Authors: Castro LC, Rogol AD, Shulman DI PMID: 22143839 [PubMed - in process] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539168 Thu, 01 Dec 2011 05:00:00 +0100 5539168 http://www.medworm.com/index.php?rid=5539167&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22143840%26dopt%3DAbstract Authors: Castro LC, Rogol AD, Shulman DI PMID: 22143840 [PubMed - in process] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539167 Thu, 01 Dec 2011 05:00:00 +0100 5539167 http://www.medworm.com/index.php?rid=5539182&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22130792%26dopt%3DAbstract Conclusion:Euthyroidism was reached despite continuation of amiodarone in all patients. Prednisone remains the preferred treatment modality of AIT type 2, because perchlorate given alone or in combination with prednisone had no better outcomes. PMID: 22130792 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539182 Wed, 30 Nov 2011 05:00:00 +0100 5539182 http://www.medworm.com/index.php?rid=5539181&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22130793%26dopt%3DAbstract Conclusions:Only the second compound heterozygous IGF1R mutations to be identified, the p.E121K/E234K variant is the cause of intrauterine growth retardation and the most severe postnatal growth failure described to date in a patient with IGF1R defects. Whether the mutant IGF1R also contributes to the diabetic phenotype, however, remains to be determined. PMID: 22130793 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5539181 Wed, 30 Nov 2011 05:00:00 +0100 5539181 http://www.medworm.com/index.php?rid=5447540&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22112804%26dopt%3DAbstract Conclusions:Daily vitamin D or calcium supplementation did not affect mortality, vascular disease, cancer mortality, or cancer incidence. PMID: 22112804 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5447540 Wed, 23 Nov 2011 05:00:00 +0100 5447540 http://www.medworm.com/index.php?rid=5447539&cid=s_37686_15_f&fid=37686&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22112805%26dopt%3DAbstract Conclusions:(11)C-metomidate PET-CT is a sensitive and specific noninvasive alternative to AVS in the management of PHA. PMID: 22112805 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism) The Journal of Clinical Endocrinology and Metabolism journals http://www.medworm.com/rss/comments.php?id=5447539 Wed, 23 Nov 2011 05:00:00 +0100 5447539