The Journal of Pain via MedWorm.com MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'The Journal of Pain' source. Tue, 07 Feb 2012 10:08:09 +0100 Instructions to Authors http://www.medworm.com/index.php?rid=5658120&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590012000235%2Fabstract%3Frss%3Dyes (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5658120 Wed, 01 Feb 2012 05:00:00 +0100 5658120 Table of Contents http://www.medworm.com/index.php?rid=5658119&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590012000089%2Fabstract%3Frss%3Dyes (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5658119 Wed, 01 Feb 2012 05:00:00 +0100 5658119 Editorial Board http://www.medworm.com/index.php?rid=5658118&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590012000077%2Fabstract%3Frss%3Dyes (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5658118 Wed, 01 Feb 2012 05:00:00 +0100 5658118 Masthead http://www.medworm.com/index.php?rid=5658117&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590012000065%2Fabstract%3Frss%3Dyes (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5658117 Wed, 01 Feb 2012 05:00:00 +0100 5658117 The Economic Cost of Chronic Noncancer Pain in Ireland: Results From the PRIME Study, Part 2 http://www.medworm.com/index.php?rid=5658110&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011008169%2Fabstract%3Frss%3Dyes Abstract: To assess the economic cost of chronic pain in Ireland, information was gathered from 140 people with chronic pain. Direct and indirect costs attributable to chronic pain and medical conditions of which chronic pain was a feature were recorded retrospectively for 12 months. Mean cost per chronic pain patient was estimated at €5,665 per year across all grades of pain, with mean costs increasing according to the severity of pain. A small proportion of patients account for the bulk of costs—the top 5% most expensive patients accounted for 26.4% of costs, with a mean cost per patient of €29,936, and the 10% most expensive patients were responsible for 42.8% of all costs. Total cost for individuals aged 20 and above was estimated at €5.34 billion per year, or 2.86% of Irish GD... The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5658110 Wed, 01 Feb 2012 05:00:00 +0100 5658110 Physical Activity, Sustained Sedentary Behavior, and Pain Modulation in Women With Fibromyalgia http://www.medworm.com/index.php?rid=5658116&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011008716%2Fabstract%3Frss%3Dyes Abstract: Fibromyalgia (FM) has been conceptualized as a disorder of the central nervous system, characterized by augmented sensory processing and an inability to effectively modulate pain. We previously reported that physical activity is related to brain processing of pain, providing evidence for a potential mechanism of pain management. The purpose of this study was to extend our work by manipulating pain modulation and determining relationships to both physical activity and sustained sedentary behavior. Eleven women with FM completed accelerometer measures of physical activity and underwent functional magnetic resonance imaging of painful heat, administered alone and during distracting cognitive tasks. Results showed that physical activity was significantly (P < .005) and positively rel... The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5658116 Mon, 16 Jan 2012 05:00:00 +0100 5658116 The Association Between Race and Neighborhood Socioeconomic Status in Younger Black and White Adults With Chronic Pain http://www.medworm.com/index.php?rid=5658114&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011008625%2Fabstract%3Frss%3Dyes Abstract: Both race and socioeconomic status (SES) contribute to disparities. We assessed the relative roles of neighborhood socioeconomic status (nSES) and race in the chronic pain experience for young adults ( (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5658114 Mon, 16 Jan 2012 05:00:00 +0100 5658114 Craving of Prescription Opioids in Patients With Chronic Pain: A Longitudinal Outcomes Trial http://www.medworm.com/index.php?rid=5658111&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011008674%2Fabstract%3Frss%3Dyes Abstract: Little is known about whether patients with chronic pain treated with opioids experience craving for their medications, whether contextual cues may influence craving, or if there is a relationship between craving and medication compliance. We hypothesized that craving for prescription opioids would be significantly correlated with the urge for more medication, preoccupation with the next dose, and current mood symptoms. We studied craving in 62 patients with chronic pain who were at low or high risk for opioid misuse, while they were enrolled in an RCT to improve prescription opioid medication compliance. Using electronic diaries, patients completed ratings of craving at monthly clinic visits and daily during a 14-day take-home period. Both groups consistently endorsed craving, w... The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5658111 Mon, 16 Jan 2012 05:00:00 +0100 5658111 Muscle Pain Differentially Modulates Short Interval Intracortical Inhibition and Intracortical Facilitation in Primary Motor Cortex http://www.medworm.com/index.php?rid=5658115&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011008704%2Fabstract%3Frss%3Dyes This article provides evidence for decreased intracortical facilitation and increased short interval intracortical inhibition in response to muscle pain. This finding is relevant to clinicians as a mechanism which may underlie restricted movement in acute and chronic pain. (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5658115 Mon, 09 Jan 2012 05:00:00 +0100 5658115 How Do I Empathize With You? Let Me Count the Ways: Relations Between Facets of Pain-Related Empathy http://www.medworm.com/index.php?rid=5658113&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011008637%2Fabstract%3Frss%3Dyes This study examined the extent to which components of empathy (ie, empathic accuracy, empathic tendencies, and empathic responses) were correlated within the context of chronic pain couples. Additionally, the interrelationships between these empathy variables and spouse responses to pain were investigated. Participants were 57 couples in which at least 1 spouse reported chronic musculoskeletal pain. Each couple participated in a videotaped interaction about the impact of pain in their lives together, after which they completed an empathic accuracy procedure. The interactions were coded for the spouse’s use of empathic responses. Couples also completed surveys about pain severity, pain interference, empathic tendencies, marital satisfaction, and perceived spousal responses (ie, solicitous... The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5658113 Mon, 09 Jan 2012 05:00:00 +0100 5658113 Repetitive Treatment With Diluted Bee Venom Reduces Neuropathic Pain Via Potentiation of Locus Coeruleus Noradrenergic Neuronal Activity and Modulation of Spinal NR1 Phosphorylation in Rats http://www.medworm.com/index.php?rid=5658112&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011008698%2Fabstract%3Frss%3Dyes Abstract: We previously demonstrated that a single injection of diluted bee venom (DBV) temporarily alleviates thermal hyperalgesia, but not mechanical allodynia, in neuropathic rats. The present study was designed to determine whether repetitive injection of DBV produces more potent analgesic effects on neuropathy-induced nociception and whether those effects are associated with increased neuronal activity in the locus coeruleus (LC) and with the suppression of spinal NMDA receptor NR1 subunit phosphorylation (pNR1). DBV (.25 mg/kg) was administered subcutaneously twice a day for 2 weeks beginning on day 15 post-chronic constrictive injury surgery. Pain responses were examined and potential changes in LC Fos expression and spinal pNR1 expression were determined. Repetitive DBV administrat... The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5658112 Thu, 05 Jan 2012 05:00:00 +0100 5658112 Submission Form http://www.medworm.com/index.php?rid=5570729&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011009175%2Fabstract%3Frss%3Dyes (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5570729 Sun, 01 Jan 2012 05:00:00 +0100 5570729 Instructions to Authors http://www.medworm.com/index.php?rid=5570728&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011009163%2Fabstract%3Frss%3Dyes (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5570728 Sun, 01 Jan 2012 05:00:00 +0100 5570728 Table of Contents http://www.medworm.com/index.php?rid=5570727&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011009151%2Fabstract%3Frss%3Dyes (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5570727 Sun, 01 Jan 2012 05:00:00 +0100 5570727 Editorial Board http://www.medworm.com/index.php?rid=5570726&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS152659001100914X%2Fabstract%3Frss%3Dyes (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5570726 Sun, 01 Jan 2012 05:00:00 +0100 5570726 Masthead http://www.medworm.com/index.php?rid=5570725&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011009138%2Fabstract%3Frss%3Dyes (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5570725 Sun, 01 Jan 2012 05:00:00 +0100 5570725 Reviewer Acknowledgments http://www.medworm.com/index.php?rid=5570724&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011009102%2Fabstract%3Frss%3Dyes The Journal of Pain thanks its Editorial Board members for helping make The Journal a success. In addition, the following individuals are gratefully acknowledged for their help in reviewing manuscripts in 2011. (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5570724 Sun, 01 Jan 2012 05:00:00 +0100 5570724 The Effects of Ethanol on the Bioavailability of Oxymorphone Extended-Release Tablets and Oxymorphone Crush-Resistant Extended-Release Tablets http://www.medworm.com/index.php?rid=5570723&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011008686%2Fabstract%3Frss%3Dyes Abstract: Adverse events may occur with an extended-release (ER) opioid if tampering or coadministration with ethanol causes excessive exposure (dose dumping) to the opioid. The effects of ethanol on the in vitro dissolution and in vivo pharmacokinetics of oxymorphone ER and oxymorphone crush-resistant formulation (CRF) were evaluated. In vitro dissolution rates were measured for oxymorphone ER 40-mg and oxymorphone CRF 40-mg tablets in aqueous solutions of 0 to 40% ethanol. In 2 in vivo, open-label, randomized, crossover studies, fasted healthy volunteers received single oral doses of oxymorphone ER 40 mg or oxymorphone CRF 40 mg with 240 mL of 0 to 40% ethanol. Naltrexone was used to minimize opioid effects. In the in vitro analyses, dissolution rates of oxymorphone ER and CRF were ... The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5570723 Sun, 01 Jan 2012 05:00:00 +0100 5570723 Investigation of Central Pain Processing in Shoulder Pain: Converging Results From 2 Musculoskeletal Pain Models http://www.medworm.com/index.php?rid=5570722&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011008601%2Fabstract%3Frss%3Dyes Abstract: Recent reports suggest deficits in conditioned pain modulation (CPM) and enhanced suprathreshold heat pain response (SHPR) potentially play a role in the development of chronic pain. The purpose of this study was to investigate whether central pain processing was altered in 2 musculoskeletal shoulder pain models. The goals of this study were to determine whether central pain processing: 1) differs between healthy subjects and patients with clinical shoulder pain; 2) changes with induction of exercise-induced muscle pain; and 3) changes 3 months after shoulder surgery. Fifty-eight patients with clinical shoulder pain and 56 age- and sex-matched healthy subjects were included in these analyses. The healthy cohort was examined before inducing EIMP, and 48 and 96 hours later. The cli... The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5570722 Sun, 01 Jan 2012 05:00:00 +0100 5570722 Test Order of Quantitative Sensory Testing Facilitates Mechanical Hyperalgesia in Healthy Volunteers http://www.medworm.com/index.php?rid=5570721&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011008170%2Fabstract%3Frss%3Dyes This article demonstrates that the test order of quantitative sensory testing is relevant in interpreting the results obtained. Reference values are suitable in the test order from which they are obtained. (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5570721 Sun, 01 Jan 2012 05:00:00 +0100 5570721 Predictors of Change in Pain and Physical Functioning Among Post-Menopausal Women With Recurrent Pain Conditions in the Women’s Health Initiative Observational Cohort http://www.medworm.com/index.php?rid=5570720&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011008613%2Fabstract%3Frss%3Dyes This study presents prospective data on change in pain and physical functioning in postmenopausal women over a 3-year period. Our results suggest depression, nonpain physical symptoms, obesity, and possibly opioid treatment are associated with worse long-term pain outcomes in this population. (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5570720 Sun, 01 Jan 2012 05:00:00 +0100 5570720 Effects of Yoga Interventions on Pain and Pain-Associated Disability: A Meta-Analysis http://www.medworm.com/index.php?rid=5570713&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011007929%2Fabstract%3Frss%3Dyes Abstract: We searched databases for controlled clinical studies, and performed a meta-analysis on the effectiveness of yoga interventions on pain and associated disability. Five randomized studies reported single-blinding and had a higher methodological quality; 7 studies were randomized but not blinded and had moderate quality; and 4 nonrandomized studies had low quality. In 6 studies, yoga was used to treat patients with back pain; in 2 studies to treat rheumatoid arthritis; in 2 studies to treat patients with headache/migraine; and 6 studies enrolled individuals for other indications. All studies reported positive effects in favor of the yoga interventions. With respect to pain, a random effect meta-analysis estimated the overall treatment effect at SMD = −.74 (CI: −.97; −.52, P <... The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5570713 Mon, 19 Dec 2011 05:00:00 +0100 5570713 Sensory Pain Qualities in Neuropathic Pain http://www.medworm.com/index.php?rid=5570719&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS152659001100811X%2Fabstract%3Frss%3Dyes This article validates a model that describes the qualities of neuropathic pain associated with diabetic peripheral neuropathy and postherpetic neuralgia. These data suggest that specific pain qualities may be associated with pain mechanisms or may be useful for predicting treatment response. (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5570719 Fri, 16 Dec 2011 05:00:00 +0100 5570719 Changes in Plasma Cytokines and Their Soluble Receptors in Complex Regional Pain Syndrome http://www.medworm.com/index.php?rid=5570714&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011008157%2Fabstract%3Frss%3Dyes This study evaluated the plasma levels of cytokines, chemokines, and their soluble receptors in 148 subjects afflicted with CRPS and in 60 gender- and age-matched healthy controls. Significant changes in plasma cytokines, chemokines, and their soluble receptors were found in subjects with CRPS as compared with healthy controls. For most analytes, these changes resulted from a distinct subset of the CRPS subjects. When the plasma data from the CRPS subjects was subjected to cluster analysis, it revealed 2 clusters within the CRPS population. The category identified as most important for cluster separation by the clustering algorithm was TNFα. Cluster 1 consisted of 64% of CRPS subjects and demonstrated analyte values similar to the healthy control individuals. Cluster 2 consisted of 36% of... The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5570714 Thu, 15 Dec 2011 05:00:00 +0100 5570714 Depletion of Endogenous Noradrenaline Does Not Prevent Spinal Cord Plasticity Following Peripheral Nerve Injury http://www.medworm.com/index.php?rid=5570718&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011007917%2Fabstract%3Frss%3Dyes This study demonstrates that endogenous noradrenaline modulates plasticity of glia and cholinergic neurons in the spinal cord after peripheral nerve injury and hence influences the pathophysiology of spinal cord changes associated with neuropathic pain. (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5570718 Mon, 12 Dec 2011 05:00:00 +0100 5570718 The Antinociceptive Activity of Intrathecally Administered Amiloride and Its Interactions With Morphine and Clonidine in Rats http://www.medworm.com/index.php?rid=5570717&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011007905%2Fabstract%3Frss%3Dyes This article presents antinociceptive synergistic interaction between amiloride and morphine, amiloride, and clonidine on thermal nociceptive tests in the rat. (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5570717 Fri, 09 Dec 2011 05:00:00 +0100 5570717 Table of Contents http://www.medworm.com/index.php?rid=5474722&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011008789%2Fabstract%3Frss%3Dyes (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5474722 Thu, 01 Dec 2011 05:00:00 +0100 5474722 Editorial Board http://www.medworm.com/index.php?rid=5474721&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011008777%2Fabstract%3Frss%3Dyes (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5474721 Thu, 01 Dec 2011 05:00:00 +0100 5474721 Masthead http://www.medworm.com/index.php?rid=5474720&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011008765%2Fabstract%3Frss%3Dyes (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5474720 Thu, 01 Dec 2011 05:00:00 +0100 5474720 Time Series Analysis of California’s Prescription Monitoring Program: Impact on Prescribing and Multiple Provider Episodes http://www.medworm.com/index.php?rid=5658106&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011007887%2Fabstract%3Frss%3Dyes This study determined whether recent changes to California’s PMP influenced: 1) the extent that practitioners issue prescriptions for a variety of Schedule II opioids; and 2) the incidence of MPEs involving these opioids. Intervention time series of California’s PMP data was used to determine the effect of requiring practitioners to transition from using triplicate prescription forms for Schedule II medications to security forms for all controlled substances. Outcome measures included changes in number of prescriptions issued for Schedule II long-acting or short-acting (SA) opioids and the MPEs involving these medications. Requiring a security form was associated with a sustained prescribing increase for SA hydromorphone, meperidine, and SA oxycodone; no prescribing changes were found ... The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5658106 Thu, 24 Nov 2011 05:00:00 +0100 5658106 Training for General Practitioners in Opioid Prescribing for Chronic Pain Based on Practice Guidelines: A Randomized Pilot and Feasibility Trial http://www.medworm.com/index.php?rid=5570716&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011007899%2Fabstract%3Frss%3Dyes This study is a pilot and feasibility study that compares 2 training experiences to improve appropriate opioid prescribing for chronic pain. Both training conditions included education in relation to opioid guidelines. Following education, 1 condition included training aimed at improving psychological flexibility and the other included training in practical knowledge and skills related to pain management. Eighty-one general practitioners (GPs) took part in the study, each having been randomly assigned to 1 of the training conditions. It proved easy to recruit GPs to the training. Overall, GPs demonstrated increased knowledge of opioid prescribing for chronic pain and decreases in concerns related to prescribing following training. However, there were no changes observed in reported prescri... The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5570716 Thu, 24 Nov 2011 05:00:00 +0100 5570716 A Pilot Study of the Tolerability and Effects of High-Definition Transcranial Direct Current Stimulation (HD-tDCS) on Pain Perception http://www.medworm.com/index.php?rid=5658107&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011006651%2Fabstract%3Frss%3Dyes This article presents preliminary tolerability and efficacy data for a new focal brain stimulation technique called high definition transcranial direct current stimulation. This technique may have applications in the management of pain. (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5658107 Mon, 21 Nov 2011 05:00:00 +0100 5658107 Physical Activity and Function in Adolescents With Chronic Pain: A Controlled Study Using Actigraphy http://www.medworm.com/index.php?rid=5658108&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011007413%2Fabstract%3Frss%3Dyes This study used subjective and objective measures to assess multiple dimensions of physical functioning in a clinical sample of adolescents with chronic pain (n = 78) and a comparison group of healthy adolescents (n = 59). Individual and pain characteristics were also examined as predictors of actigraphy variables within the chronic pain sample. Results indicated that adolescents with chronic pain demonstrate significant impairment in subjective measures of physical functioning and evidence lower levels of physical activity. Actigraphic measures of physical activity were moderately correlated with self-report measures of physical functioning. Individual characteristics, including adolescent age, sex, and Body Mass Index percentile, were associated with physical activity levels among adoles... The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5658108 Fri, 18 Nov 2011 05:00:00 +0100 5658108 Latent Myofascial Trigger Points are Associated With an Increased Antagonistic Muscle Activity During Agonist Muscle Contraction http://www.medworm.com/index.php?rid=5474719&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011007632%2Fabstract%3Frss%3Dyes This study shows that MTPs are associated with reduced efficiency of reciprocal linhibition, which may contribute to the delayed and incomplete muscle relaxation following exercise, disordered fine movement control, and unbalanced muscle activation. Elimination of latent MTPs and/or prevention of latent MTPs from becoming active may improve motor functions. (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5474719 Mon, 14 Nov 2011 05:00:00 +0100 5474719 Swearing as a Response to Pain—Effect of Daily Swearing Frequency http://www.medworm.com/index.php?rid=5474718&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011007620%2Fabstract%3Frss%3Dyes This article presents further evidence that, for many people, swearing (cursing) provides readily available and effective relief from pain. However, overuse of swearing in everyday situations lessens its effectiveness as a short-term intervention to reduce pain. (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5474718 Mon, 14 Nov 2011 05:00:00 +0100 5474718 The Interruptive Effect of Pain in a Multitask Environment: An Experimental Investigation http://www.medworm.com/index.php?rid=5658109&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011007619%2Fabstract%3Frss%3Dyes This article is concerned with the interruptive effect of pain on people’s task performance by using an adapted task-switching paradigm. This adapted paradigm may offer unique possibilities to investigate how pain interferes with task performance while people repeat and switch between multiple tasks in a multitask environment. (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5658109 Thu, 10 Nov 2011 05:00:00 +0100 5658109 Individual Differences in the Effects of Music Engagement on Responses to Painful Stimulation http://www.medworm.com/index.php?rid=5474717&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011007450%2Fabstract%3Frss%3Dyes Abstract: Engaged attention, including music listening, has shown mixed results when used as a method for reducing pain. Applying the framework of constructivism, we extend the concept of engagement beyond attention/distraction to include all cognitive and emotional/motivational processes that may be recruited in order to construct an alternative experience to pain and thus reduce pain. Using a music-listening task varying in task demand, we collected stimulus-evoked potentials, pupil dilation, and skin conductance responses to noxious electrocutaneous stimulations as indicators of central and peripheral arousal, respectively. Trait anxiety (Spielberger State-Trait Anxiety Inventory) and absorption (Tellegen Absorption Scale) provided indicators of individual differences. One hundred and f... The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5474717 Thu, 10 Nov 2011 05:00:00 +0100 5474717 Feeling More Pain, Yet Showing Less: The Influence of Social Threat on Pain http://www.medworm.com/index.php?rid=5474716&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011007176%2Fabstract%3Frss%3Dyes Abstract: The present study investigated the effects of social threat to physical integrity on reported pain and facial pain expression. Predictions of a cognitive appraisal model and a communicative perspective on pain expression were compared. Participants (N = 67) received 5 electric pain stimuli administered by a confederate. They were led to believe that 5 pain stimuli were the minimum, a fixed amount, or the maximum number of pain stimuli allowed, thereby varying the social threat posed by the confederate. Reported pain and facial pain expression were recorded during the delivery of pain stimuli. Increased perceived social threat led to an increase of reported pain, specifically for high pain catastrophizing participants, while it led to a reduction of facial pain expression. This is... The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5474716 Fri, 04 Nov 2011 04:00:00 +0100 5474716 Submission Form http://www.medworm.com/index.php?rid=5378790&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS152659001100839X%2Fabstract%3Frss%3Dyes (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5378790 Tue, 01 Nov 2011 04:00:00 +0100 5378790 Instructions to Authors http://www.medworm.com/index.php?rid=5378789&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011008388%2Fabstract%3Frss%3Dyes (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5378789 Tue, 01 Nov 2011 04:00:00 +0100 5378789 Table of Contents http://www.medworm.com/index.php?rid=5378788&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011008042%2Fabstract%3Frss%3Dyes (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5378788 Tue, 01 Nov 2011 04:00:00 +0100 5378788 Editorial Board http://www.medworm.com/index.php?rid=5378787&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011008030%2Fabstract%3Frss%3Dyes (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5378787 Tue, 01 Nov 2011 04:00:00 +0100 5378787 Masthead http://www.medworm.com/index.php?rid=5378786&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011008029%2Fabstract%3Frss%3Dyes (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5378786 Tue, 01 Nov 2011 04:00:00 +0100 5378786 Pain Relief Report Commended for Highlighting Self-Management, Integrative Approaches http://www.medworm.com/index.php?rid=5378785&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011007036%2Fabstract%3Frss%3Dyes This report provides a thorough review of the impact of chronic pain and an excellent discussion of pertinent issues and recommendations for change. Specifically, we would like to highlight several points including the importance of emphasizing a self-management approach and working to enhance self-efficacy of patients with chronic pain problems as well as the focus on interdisciplinary care. Furthermore, several of the exemplar programs cited incorporate mind-body approaches. The report also provides a nice summary of research on complementary and alternative (CAM) therapies for pain and is inclusive of CAM practitioners in the formulation of the team. The research discussion notes the shortcomings of the reductionistic RCT model and suggests options for other approaches such as comparati... The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5378785 Tue, 01 Nov 2011 04:00:00 +0100 5378785 Excess Risk of Temporomandibular Disorder Associated With Cigarette Smoking in Young Adults http://www.medworm.com/index.php?rid=5570715&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS152659001100736X%2Fabstract%3Frss%3Dyes Abstract: Evidence suggests that the effect of cigarette smoking on chronic pain is stronger in younger than older adults. This case-control study investigated whether age modified an effect of smoking on temporomandibular disorder (TMD) in 299 females aged 18 to 60 years. It also investigated the extent to which this relationship was explained by psychological profile, inflammatory response, and allergy. Cases were defined using the Research Diagnostic Criteria for Temporomandibular Disorders based on clinical examination. Psychological profile was evaluated using standardized instruments. Inflammatory response was evaluated with 11 cytokines isolated in plasma. History of allergy conditions was self-reported. Odds ratios (ORs) for the effect of smoking were calculated using binary logist... The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5570715 Fri, 28 Oct 2011 04:00:00 +0100 5570715 Postoperative Pain Trajectories in Chronic Pain Patients Undergoing Surgery: The Effects of Chronic Opioid Pharmacotherapy on Acute Pain http://www.medworm.com/index.php?rid=5474714&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011007048%2Fabstract%3Frss%3Dyes Abstract: For 2 weeks following surgery, 55 patients with preexisting chronic pain (CP) reported daily postoperative pain with movement and at rest. Of these, 30 CP patients used opioid pharmacotherapy for CP management and 25 did not. We modeled pain resolution in each patient using a linear fit so that each patient yielded 2 scores for each pain rating: 1) an intercept, or initial level of pain, immediately after surgery; and 2) a slope, or rate of pain resolution. The patients not using opioid pharmacotherapy had a mean pain with movement intercept of 5.4 and a slope of −.20, while the patients using opioid pharmacotherapy had a significantly higher mean intercept of 7.68 (P = .001) and a slope of −.21, sustaining higher pain levels over days. The opioid pharmacotherapy patients ha... The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5474714 Fri, 28 Oct 2011 04:00:00 +0100 5474714 Pain-Related Fear, Perceived Harmfulness of Activities, and Functional Limitations in Complex Regional Pain Syndrome Type I http://www.medworm.com/index.php?rid=5474711&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS152659001100664X%2Fabstract%3Frss%3Dyes Abstract: Numerous studies have shown that pain-related fear is one of the strongest predictors of pain disability in patients with chronic musculoskeletal pain, and there is evidence that the reduction of pain-related fear through an exposure treatment can be associated with restoration of functional abilities in patients with complex regional pain syndrome type I (CRPS-I). These findings suggest that pain-related fear may be associated with functional limitations in neuropathic pain as well. The aim of the current study was to test whether the debilitating role of pain-related fear generalizes to patients with CRPS-I. The results of 2 studies are presented. Study I includes a sample of patients with early CRPS-I referred to an outpatient pain clinic. In Study II, patients with chronic CR... The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5474711 Fri, 28 Oct 2011 04:00:00 +0100 5474711 Observational Learning and Pain-Related Fear: An Experimental Study With Colored Cold Pressor Tasks http://www.medworm.com/index.php?rid=5474713&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011006663%2Fabstract%3Frss%3Dyes This study provides preliminary evidence for observational learning of pain-related fear in humans.Perspective: Fear of pain can be more disabling than pain itself, and is a risk factor for chronic pain. Knowledge about the acquisition of pain-related fear may help to develop novel pain management programs. This study is one of the first to demonstrate the effects of observational learning on pain-related fear. (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5474713 Mon, 24 Oct 2011 04:00:00 +0100 5474713 The Psychometric Properties of the Dot-Probe Paradigm When Used in Pain-Related Attentional Bias Research http://www.medworm.com/index.php?rid=5474715&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011006808%2Fabstract%3Frss%3Dyes Abstract: In recent years, there has been increasing acknowledgment of the need for psychometric data regarding the dot-probe paradigm. The aim of the present study was to provide some data on the psychometric properties of the dot-probe paradigm in the context of pain-related research. Using the data of a large pain-free sample and a large chronic pain sample, the present study examined the psychometric properties of a picture- and word-based dot-probe task. It also examined the data of idiosyncratically selected stimuli designed to be relevant to each participant and compared this with the data of neutral stimuli and nonsalient pain-related stimuli. Poor levels of internal consistency (α range: −.44 to .28; split-half r range: −.35 to .11) and test-retest reliability (r range: −.1... The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5474715 Mon, 10 Oct 2011 04:00:00 +0100 5474715 Submission Form http://www.medworm.com/index.php?rid=5283204&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011007656%2Fabstract%3Frss%3Dyes (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5283204 Sat, 01 Oct 2011 04:00:00 +0100 5283204 Instructions to Authors http://www.medworm.com/index.php?rid=5283203&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011007644%2Fabstract%3Frss%3Dyes (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5283203 Sat, 01 Oct 2011 04:00:00 +0100 5283203 Table of Contents http://www.medworm.com/index.php?rid=5283202&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011007504%2Fabstract%3Frss%3Dyes (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5283202 Sat, 01 Oct 2011 04:00:00 +0100 5283202 Editorial Board http://www.medworm.com/index.php?rid=5283201&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011007498%2Fabstract%3Frss%3Dyes (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5283201 Sat, 01 Oct 2011 04:00:00 +0100 5283201 Masthead http://www.medworm.com/index.php?rid=5283200&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011007486%2Fabstract%3Frss%3Dyes (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5283200 Sat, 01 Oct 2011 04:00:00 +0100 5283200 Understanding and Treating Opioid Addiction in a Patient With Cancer Pain http://www.medworm.com/index.php?rid=5283190&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS152659001100705X%2Fabstract%3Frss%3Dyes Mr. D. is a 25-year-old male who has struggled with heroin addiction since his late teens. He had initially completed a 30-day rehabilitation program but relapsed immediately and entered another 2-week program. It was during this hospitalization that laboratory abnormalities were noted, and he was subsequently diagnosed with acute myeloid leukemia. He received high-dose induction chemotherapy with cytarabine and daunorubicin but did not achieve remission. He was reinduced, achieved remission, and subsequently underwent stem cell transplantation with his younger sister as a donor. Throughout this prolonged 8-week hospitalization and treatment, he suffered from severe mucositis as well as abdominal pain of unclear etiology requiring patient controlled analgesia (PCA), delivering, at 1 point,... The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5283190 Sat, 01 Oct 2011 04:00:00 +0100 5283190 Gout: Current Insights and Future Perspectives http://www.medworm.com/index.php?rid=5378776&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011006638%2Fabstract%3Frss%3Dyes Abstract: Gout is a relatively common inflammatory arthritis that is typically known to occur in middle-aged men. The prevalence of gout appears to be shifting, however, and is increasing in the elderly population. Gout is characterized by severely intense pain and can greatly impact patient quality of life. The study of gout and associated conditions appears to have received research attention in the past, however there is a resurgence in gout interest due to the abundance of novel evidence surrounding its diagnosis, pathophysiology, and treatment. In this review we describe a general overview of gout including its assessment/diagnosis, clinical presentations, predisposing factors, pathophysiology, abortive and prophylactic therapy to control gouty inflammation, and the potential future d... The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5378776 Wed, 28 Sep 2011 04:00:00 +0100 5378776 Executive Function in Chronic Pain Patients and Healthy Controls: Different Cortical Activation During Response Inhibition in Fibromyalgia http://www.medworm.com/index.php?rid=5474712&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011006614%2Fabstract%3Frss%3Dyes Abstract: The primary symptom of fibromyalgia (FM) is chronic, widespread pain; however, patients report additional symptoms including decreased concentration and memory. Performance-based deficits are seen mainly in tests of working memory and executive function. Neural correlates of executive function were investigated in 18 FM patients and 14 age-matched healthy controls during a simple Go/No-Go task (response inhibition) while they underwent functional magnetic resonance imaging (fMRI). Performance was not different between FM and healthy control, in either reaction time or accuracy. However, fMRI revealed that FM patients had lower activation in the right premotor cortex, supplementary motor area, midcingulate cortex, putamen and, after controlling for anxiety, in the right insular co... The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5474712 Mon, 26 Sep 2011 04:00:00 +0100 5474712 Pain Education in North American Medical Schools http://www.medworm.com/index.php?rid=5474710&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011006468%2Fabstract%3Frss%3Dyes This study assessed the scope and scale of pain education programs in U.S. and Canadian medical schools. Significant gaps between recommended pain curricula and documented educational content were identified. In short, pain education was limited and fragmentary. Innovative and integrated pain education in primary medical education is needed. (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5474710 Mon, 26 Sep 2011 04:00:00 +0100 5474710 I Am Touched by Your Pain: Limb-Specific Modulation of the Cortical Response to a Tactile Stimulation During Pain Observation http://www.medworm.com/index.php?rid=5378783&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011006456%2Fabstract%3Frss%3Dyes Abstract: The observation of pain in other individuals is known to impact the cerebral activity in regions dedicated to one’s nociception, as well as the behavior toward the person in pain. However, it remains unclear whether this shared representation for pain modulates somatosensory processing to nonpainful stimuli and whether this modulation is limb specific. Twenty right-handed healthy participants viewed a series of pictures depicting right hands or right feet in painful or nonpainful situations while light repetitive (25 Hz) mechanical stimuli were applied to the hand. The cortical excitability to these nonpainful stimuli was measured through the energy in the 25-Hz frequency band of electroencephalographic data. Following picture onset, a combination of nonspecific and specific mo... The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5378783 Mon, 12 Sep 2011 04:00:00 +0100 5378783 Table of Contents http://www.medworm.com/index.php?rid=5174531&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011007127%2Fabstract%3Frss%3Dyes (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5174531 Tue, 30 Aug 2011 05:34:46 +0100 5174531 Editorial Board http://www.medworm.com/index.php?rid=5174530&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011007115%2Fabstract%3Frss%3Dyes (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5174530 Tue, 30 Aug 2011 05:34:46 +0100 5174530 Masthead http://www.medworm.com/index.php?rid=5174529&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011007103%2Fabstract%3Frss%3Dyes (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5174529 Tue, 30 Aug 2011 05:34:46 +0100 5174529 Emotional Intelligence and Acute Pain: The Mediating Effect of Negative Affect http://www.medworm.com/index.php?rid=5378784&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011006626%2Fabstract%3Frss%3Dyes The objective of the present study was to analyze the influence of EI, measured using the Mayer-Salovey-Caruso Emotional Intelligence Test (MSCEIT), on the level of sensory and affective pain generated by an experimental cold pressor task (CPT). In addition, we examined the influence of negative affect, as measured through the Positive and Negative Affect Schedule (PANAS), on the relationship between EI and pain. Healthy college students (N = 67) completed measures of EI before the CPT, during which they submerged their nondominant hand into ice water, and they completed measures of negative emotional state before and after the CPT. Participants with higher EI rated pain as less intense and perceived it as less unpleasant. Greater emotional intelligence predicted less pain in this experime... The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5378784 Wed, 24 Aug 2011 04:00:00 +0100 5378784 A Qualitative Analysis of a Randomized Controlled Trial Comparing a Cognitive-Behavioral Treatment With Education http://www.medworm.com/index.php?rid=5174521&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011004494%2Fabstract%3Frss%3Dyes Abstract: Cognitive behavioral therapy (CBT) is a widely accepted psychosocial treatment for chronic pain. However, the efficacy of CBT has not been investigated within a rural setting. Furthermore, few studies have utilized first-person accounts to qualitatively investigate the key treatment elements and processes of change underlying the well-documented quantitative improvements associated with CBT. To address these gaps, we conducted a randomized controlled trial (RCT) investigating the efficacy of group CBT compared to an active education condition (EDU) within a rural, low-literacy population. Posttreatment semistructured interviews of 28 CBT and 24 EDU treatment completers were qualitatively analyzed. Emerging themes were collated to depict a set of finalized thematic maps to visuall... The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5174521 Thu, 11 Aug 2011 23:00:00 +0100 5174521 “He Says, She Says”: A Comparison of Fathers’ and Mothers’ Verbal Behavior During Child Cold Pressor Pain http://www.medworm.com/index.php?rid=5378782&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011006328%2Fabstract%3Frss%3Dyes Abstract: Mothers’ behavior has a powerful impact on child pain. Maternal attending talk (talk focused on child pain) is associated with increased child pain whereas maternal non-attending talk (talk not focused on child pain) is associated with decreased child pain. The present study compared mothers’ and fathers’ verbal behavior during child pain. Forty healthy 8- to 12-year-old children completed the cold pressor task (CPT)—once with their mothers present and once with their fathers present in a counterbalanced order. Parent verbalizations were coded as Attending Talk or Non-Attending Talk. Results indicated that child symptom complaints were positively correlated with parent Attending Talk and negatively correlated with parent Non-Attending Talk. Furthermore, child pain toleran... The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5378782 Mon, 08 Aug 2011 04:00:00 +0100 5378782 Pain Acceptance, Hope, and Optimism: Relationships to Pain and Adjustment in Patients With Chronic Musculoskeletal Pain http://www.medworm.com/index.php?rid=5378780&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011006298%2Fabstract%3Frss%3Dyes This study conducted in obese patients with persistent musculoskeletal pain (N = 89) examined the degree to which pain acceptance and hope explained pain intensity, pain unpleasantness, psychological distress, and pain-related disability, after controlling for the effects of optimism. In correlational analyses, pain acceptance and optimism were associated with psychological distress and pain disability with hope being related to only psychological distress. Pain acceptance, optimism, and hope were not significantly associated with pain. Hierarchical linear regression (HLR) analyses found that pain acceptance remained a significant predictor of psychological distress and pain disability after controlling for optimism, demographic, and medical variables. HLR analyses found that hope was not ... The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5378780 Mon, 08 Aug 2011 04:00:00 +0100 5378780 Efficacy and Safety of Buprenorphine Transdermal System (BTDS) for Chronic Moderate to Severe Low Back Pain: A Randomized, Double-Blind Study http://www.medworm.com/index.php?rid=5378781&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011006316%2Fabstract%3Frss%3Dyes This article presents results of a pivotal Phase 3 study that assesses a new treatment for the management of chronic low back pain: a transdermal patch containing the opioid buprenorphine (BTDS). In this active controlled, superiority study with an enriched design, BTDS 20 was found to be efficacious and generally well tolerated. (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5378781 Tue, 02 Aug 2011 04:00:00 +0100 5378781 Assessment of the Quality of Postherpetic Neuralgia Treatment Information on the Internet http://www.medworm.com/index.php?rid=5378779&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011006286%2Fabstract%3Frss%3Dyes In conclusion, many different postherpetic neuralgia treatments are found on the Internet and patients may be left separating recommended treatments from nonrecommended treatments without help from their healthcare providers.Perspective: This study examined the quality of websites related to postherpetic neuralgia treatment. The results demonstrated that most websites offering advice on postherpetic neuralgia treatment are of only moderate quality and often offer treatment suggestions that are nonbeneficial. Patients and providers must use caution when taking advice from these sites. (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5378779 Tue, 02 Aug 2011 04:00:00 +0100 5378779 Predictive Value of rTMS in the Identification of Responders to Epidural Motor Cortex Stimulation Therapy for Pain http://www.medworm.com/index.php?rid=5283199&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011006274%2Fabstract%3Frss%3Dyes This study was designed to assess the value of repetitive transcranial magnetic stimulation (rTMS) to predict the efficacy of epidural motor cortex stimulation (EMCS) to treat neuropathic pain. We have included 59 patients treated by EMCS for more than 1 year and in whom active and sham 10Hz-rTMS sessions were performed as preoperative tests, targeted over the cortical representation of the painful area. Analgesic effects were rated on a visual analogue scale. The real rTMS efficacy was determined by subtracting the effect of the sham stimulation on pain scores from that of the active stimulation (active-sham calculation). Pain scores were significantly reduced by active rTMS and EMCS, but not by sham rTMS. Twenty-six of the 33 patients (79%) who responded to active rTMS and all the 21 pat... The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5283199 Tue, 02 Aug 2011 04:00:00 +0100 5283199 Submission Form http://www.medworm.com/index.php?rid=5095813&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011006821%2Fabstract%3Frss%3Dyes (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5095813 Sun, 31 Jul 2011 23:00:00 +0100 5095813 Instructions to Authors http://www.medworm.com/index.php?rid=5095812&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS152659001100681X%2Fabstract%3Frss%3Dyes (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5095812 Sun, 31 Jul 2011 23:00:00 +0100 5095812 Table of Contents http://www.medworm.com/index.php?rid=5095811&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011006717%2Fabstract%3Frss%3Dyes (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5095811 Sun, 31 Jul 2011 23:00:00 +0100 5095811 Editorial Board http://www.medworm.com/index.php?rid=5095810&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011006705%2Fabstract%3Frss%3Dyes (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5095810 Sun, 31 Jul 2011 23:00:00 +0100 5095810 Masthead http://www.medworm.com/index.php?rid=5095809&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011006699%2Fabstract%3Frss%3Dyes (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5095809 Sun, 31 Jul 2011 23:00:00 +0100 5095809 Don’t Throw the Hot Plate Out With the Bath Water http://www.medworm.com/index.php?rid=5095808&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011006262%2Fabstract%3Frss%3Dyes Yezierski and Vierck’s response to our article concludes that the “… limitations of the hot plate and other reflex assays are sufficient to remove these approaches from preclinical pain assessment.” I share concerns about the validity of the hot plate test. The point of difference is that Yezierski and Vierck are concerned about the clinical relevance and our article focused on practical confounds. The clearly stated objective of our study was to determine whether non-nociceptive factors influence hot plate latency. The results indicate that body weight, activity, and habituation do not have a major influence on hot plate latency. The fact that these practical concerns are negligible does not address the issue of clinical relevance. There is no question that other nociceptive tests... The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5095808 Sun, 31 Jul 2011 23:00:00 +0100 5095808 Should the Hot-Plate Test Be Reincarnated? http://www.medworm.com/index.php?rid=5095807&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011006249%2Fabstract%3Frss%3Dyes There is growing concern regarding the failure of translational research to produce effective, long-term treatments of chronic pain. Most of the criticism has targeted the validity and clinical relevance of laboratory animal models of pain Because preclinical studies cannot benefit from self-report—a key component of human pain studies—we observe behavioral responses of laboratory animals that reduce, terminate, or avoid nociceptive stimulation. Any relevance of these responses to the sensation of pain requires mediation by a central neural circuit that includes the cerebral cortex, where processing of nociceptive input is a fundamental prerequisite for pain perception by humans. That is, any valid measure of pain behavior must engage the structures responsible for the sensation being ... The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5095807 Sun, 31 Jul 2011 23:00:00 +0100 5095807 Factors Affecting Placebo Acceptability: Deception, Outcome, and Disease Severity http://www.medworm.com/index.php?rid=5095805&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011004482%2Fabstract%3Frss%3Dyes This study represents an empirical examination of analgesic placebo acceptability among lay individuals. This article is the first to systematically manipulate deception, treatment outcome, and disease severity to determine how these factors interact to differentially determine placebo acceptability—a highly relevant finding that informs the clinical use of placebo. (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5095805 Sun, 31 Jul 2011 23:00:00 +0100 5095805 Association of Smoking and Chronic Pain Syndromes in Kentucky Women http://www.medworm.com/index.php?rid=5095802&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011004196%2Fabstract%3Frss%3Dyes This study provides evidence of an association between chronic pain and cigarette smoking that is reduced in former smokers.Perspective: This paper presents the association between smoking and musculoskeletal pain syndromes among Kentucky women. This finding may provide additional opportunities for intervention in patients with chronic pain. (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5095802 Sun, 31 Jul 2011 23:00:00 +0100 5095802 The Neuropathic Components of Chronic Low Back Pain: A Prospective Multicenter Study Using the DN4 Questionnaire http://www.medworm.com/index.php?rid=5283196&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011006304%2Fabstract%3Frss%3Dyes This study confirms the psychometric properties of the DN4 questionnaire to assess neuropathic pain in patients with low back pain. Neuropathic mechanisms largely contribute to pain in the lower limb as compared to the back, but neuropathic pain is not restricted to typical radiculopathy. This may have significant implications for the choice of treatment strategy in these patients. (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5283196 Mon, 25 Jul 2011 04:00:00 +0100 5283196 Early Improvement in Pain Predicts Pain Response at Endpoint in Patients With Fibromyalgia http://www.medworm.com/index.php?rid=5283197&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011006067%2Fabstract%3Frss%3Dyes Abstract: An unanswered, but clinically important question is whether there are early indicators that a patient might respond to duloxetine treatment for fibromyalgia pain. To address this question, pooled data from 4 double-blind, placebo-controlled trials in duloxetine-treated patients (N = 797) with primary fibromyalgia as defined by the American College for Rheumatology were analyzed. Classification and Regression Tree (CART) analysis was used to determine what level of early pain improvement as measured by the 24-hour average pain severity question on the Brief Pain Inventory (BPI) best predicted later response. The predictor variables tested were 10, 15, 20, 25, and 30% decrease in BPI 24-hour average pain from baseline to Week 1 and Week 2. The results of the CART analysis showed th... The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5283197 Mon, 18 Jul 2011 04:00:00 +0100 5283197 Impaired Hand Size Estimation in CRPS http://www.medworm.com/index.php?rid=5283198&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011006055%2Fabstract%3Frss%3Dyes Abstract: A triad of clinical symptoms, ie, autonomic, motor and sensory dysfunctions, characterizes complex regional pain syndromes (CRPS). Sensory dysfunction comprises sensory loss or spontaneous and stimulus-evoked pain. Furthermore, a disturbance in the body schema may occur. In the present study, patients with CRPS of the upper extremity and healthy controls estimated their hand sizes on the basis of expanded or compressed schematic drawings of hands. In patients with CRPS we found an impairment in accurate hand size estimation; patients estimated their own CRPS-affected hand to be larger than it actually was when measured objectively. Moreover, overestimation correlated significantly with disease duration, neglect score, and increase of two-point-discrimination-thresholds (TPDT) com... The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5283198 Mon, 11 Jul 2011 04:00:00 +0100 5283198 Guideline Warfare Over Interventional Therapies for Low Back Pain: Can We Raise the Level of Discourse? http://www.medworm.com/index.php?rid=5095795&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011006079%2Fabstract%3Frss%3Dyes Abstract: As guidelines proliferate and are used to inform efforts to improve the quality and efficiency of care, disputes over guideline recommendations are likely to become more common and contentious. It is appropriate for guidelines to come under close scrutiny, given their important clinical and policy implications, and critiques that point out missing evidence, improper methods, or errors in interpretation can be valuable. But for critiques to be valid, they should be based on accurate information and a sound scientific basis. A 2009 guideline sponsored by the American Pain Society (APS) on the use of invasive tests and interventional procedures found insufficient evidence to make recommendations for most interventional procedures. It was subsequently the subject of lengthy critiques... The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5095795 Sun, 10 Jul 2011 23:00:00 +0100 5095795 Endogenous Opioids Released During Non-Nociceptive Environmental Stress Induce Latent Pain Sensitization Via a NMDA-Dependent Process http://www.medworm.com/index.php?rid=5283195&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS152659001100592X%2Fabstract%3Frss%3Dyes This study provides some preclinical evidence that pain intensity is not only the result of nociceptive input level but is also dependent on the individual history, especially prior life stress events associated with endogenous opioid release.Perspective: Based on these preclinical data, it would be of clinical interest to evaluate whether prior stressful events may also affect further pain sensation in humans. Moreover, this preclinical model could be a good tool for evaluating new therapeutic strategies for relieving pain hypersensitivity. (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5283195 Mon, 04 Jul 2011 04:00:00 +0100 5283195 Involvement of NGF in the Rat Model of Persistent Muscle Pain Associated With Taut Band http://www.medworm.com/index.php?rid=5283194&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS152659001100589X%2Fabstract%3Frss%3Dyes Abstract: Myofascial pain syndrome (MPS) is an important clinical condition characterized by chronic muscle pain and a myofascial trigger point (MTrP) located in a taut band (TB). However, its pathogenic mechanism is still unclear. We developed an animal model relevant to conditions of MPS, and analyzed the mechanism of the muscle pain in this model. We applied eccentric contraction (EC) to a rat’s gastrocnemius muscle (GM) for 2 weeks, and examined the mechanical withdrawal thresholds, histological changes, and expressions and contents of nerve growth factor (NGF). The mechanical withdrawal threshold decreased significantly at the next day of first EC and continued up to 9 days after EC. TBs were palpable at 3 to 8 days after initiation of EC. In EC animals, necrotic and regenerating mu... The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5283194 Fri, 01 Jul 2011 04:00:00 +0100 5283194 Association Between Polymorphisms in Serotonin and Dopamine-Related Genes and Endogenous Pain Modulation http://www.medworm.com/index.php?rid=5095800&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011004160%2Fabstract%3Frss%3Dyes This article presents an association between the serotonin transporter gene polymorphism (5-HTTLPR) and pain modulation derived by nonpainful conditioned pain modulation (CPMnonpainful), rather than painful conditioned pain modulation (CPMpainful). These findings emphasize the complex role of serotonin in pain modulation, and highlight the importance of genetic studies in the understanding of interindividual differences in sensitivity to pain. (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5095800 Thu, 30 Jun 2011 23:00:00 +0100 5095800 Submission Form http://www.medworm.com/index.php?rid=4997454&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011006390%2Fabstract%3Frss%3Dyes (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=4997454 Thu, 30 Jun 2011 23:00:00 +0100 4997454 Instructions to Authors http://www.medworm.com/index.php?rid=4997453&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011006389%2Fabstract%3Frss%3Dyes (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=4997453 Thu, 30 Jun 2011 23:00:00 +0100 4997453 Table of Contents http://www.medworm.com/index.php?rid=4997452&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011006377%2Fabstract%3Frss%3Dyes (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=4997452 Thu, 30 Jun 2011 23:00:00 +0100 4997452 Editorial Board http://www.medworm.com/index.php?rid=4997451&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011006365%2Fabstract%3Frss%3Dyes (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=4997451 Thu, 30 Jun 2011 23:00:00 +0100 4997451 Masthead http://www.medworm.com/index.php?rid=4997450&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011006353%2Fabstract%3Frss%3Dyes (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=4997450 Thu, 30 Jun 2011 23:00:00 +0100 4997450 Evaluation of Leukemia Inhibitory Factor (LIF) in a Rat Model of Postoperative Pain http://www.medworm.com/index.php?rid=4997449&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011004202%2Fabstract%3Frss%3Dyes In conclusion, LIF is not a target for postoperative analgesia; LIF may be important for skin and muscle repair and regeneration after incision.Perspective: This article highlights an incision pain model for the study of factors involved in nociception. The study demonstrates that LIF in is an unlikely target for novel early postoperative analgesics. (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=4997449 Thu, 30 Jun 2011 23:00:00 +0100 4997449 Written Emotional Disclosure of Trauma and Trauma History Alter Pain Sensitivity http://www.medworm.com/index.php?rid=4997447&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011000332%2Fabstract%3Frss%3Dyes We examined the immediate affective and physiological effects of written emotional disclosure and evaluated the pain modulatory effects of this personally relevant method of affect induction in women with and without trauma history. Participants wrote for 20 minutes about a traumatic or neutral topic prior to the thermal pain threshold and the ischemic pain tolerance tests. Written disclosure of trauma increased negative affect and skin conductance, which resulted in increased pain sensitivity on heat threshold tests. Trauma history was associated with lower basal ischemic pain tolerance under the neutral writing condition; however, this effect was reversed by disclosure of trauma, suggesting that preexisting differences in pain sensitivity and pain modulation may be related to lifetime hi... The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=4997447 Thu, 30 Jun 2011 23:00:00 +0100 4997447 Sequential and Base Rate Analysis of Emotional Validation and Invalidation in Chronic Pain Couples: Patient Gender Matters http://www.medworm.com/index.php?rid=5378778&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011005529%2Fabstract%3Frss%3Dyes This article presents analyses of both sequences and base rates of chronic pain couples’ communication patterns, focusing on validation and invalidation. These results may potentially improve psychosocial treatments for these couples, by addressing sequential interactions of intimacy and empathy. (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5378778 Mon, 27 Jun 2011 04:00:00 +0100 5378778 Activity Patterns in Chronic Pain: Underlying Dimensions and Associations With Disability and Depressed Mood http://www.medworm.com/index.php?rid=5283193&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011005888%2Fabstract%3Frss%3Dyes Abstract: Activity patterns are believed to play an important role in the development and perpetuation of chronic pain. So far, 3 important activity patterns have been studied: avoidance behavior, persistence behavior, and pacing behavior. Yet, empirical evidence is limited and inconclusive about the relationships between these activity patterns and important outcomes. Therefore, the present study was aimed at identifying activity patterns by means of factor analyses and determining their relationship with disability and depressive symptomatology in participants with chronic pain (N = 132). Items across different measurement instruments pertaining to 1 particular activity pattern were aggregated, and submitted to factor analysis. Results from 3 separate factor analyses revealed 6 distinc... The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5283193 Mon, 27 Jun 2011 04:00:00 +0100 5283193 Follow-Up Psychophysical Studies in Bortezomib-Related Chemoneuropathy Patients http://www.medworm.com/index.php?rid=5174528&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011005876%2Fabstract%3Frss%3Dyes Abstract: Many frontline chemotherapeutic agents produce robust neuropathy as a dose-limiting side effect; however, the persistence of chemotherapy-related sensory disturbances and pain are not well documented. We have previously investigated the qualities of bortezomib-induced pain, and now seek to determine the ongoing nature of this pain. Twenty-six control subjects and 11 patients who had previously been treated with bortezomib and who were experiencing ongoing pain consented to recurring quantitative sensory testing. A pilot immunohistochemistry study of skin innervation was also performed on patient-obtained biopsies. Psychophysical testing in patients revealed persistent changes including decreased skin temperature in the area of pain, diminished touch and sharpness detection, incre... The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5174528 Sun, 26 Jun 2011 23:00:00 +0100 5174528 The Specificity and Mechanisms of Hemilateral Sensory Disturbances in Complex Regional Pain Syndrome http://www.medworm.com/index.php?rid=5174525&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011004846%2Fabstract%3Frss%3Dyes Abstract: Hyperalgesia often extends from the affected limb to the ipsilateral forehead in patients with complex regional pain syndrome (CRPS). To investigate whether this is more common in CRPS than other chronic pain conditions, pressure-pain thresholds and sharpness to a firm bristle were assessed on each side of the forehead, at the pain site, and at an equivalent site on the contralateral side in 32 patients with chronic pain other than CRPS (neuropathic or nociceptive limb pain, radicular pain with referral to a lower limb or postherpetic neuralgia), and in 34 patients with CRPS. Ipsilateral forehead hyperalgesia to pressure pain was detected in 59% of CRPS patients compared with only 13% of patients with other forms of chronic pain. Immersion of the CRPS-affected limb in painfully c... The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5174525 Sun, 26 Jun 2011 23:00:00 +0100 5174525 Overexpression of GDNF in the Uninjured DRG Exerts Analgesic Effects on Neuropathic Pain Following Segmental Spinal Nerve Ligation in Mice http://www.medworm.com/index.php?rid=5378777&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011005499%2Fabstract%3Frss%3Dyes This article shows that GDNF exerts its analgesic effects on neuropathic pain by acting on the central terminals of uninjured DRG neurons and/or on the spinal cells targeted by these neurons. Therefore, research focusing on these GDNF-dependent neurons in the uninjured DRG would provide a new strategy for treating neuropathic pain. (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5378777 Mon, 20 Jun 2011 04:00:00 +0100 5378777 Chronic Pain in Adolescents Is Associated With Suicidal Thoughts and Behaviors http://www.medworm.com/index.php?rid=5283191&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011004895%2Fabstract%3Frss%3Dyes This study investigates whether chronic pain is associated with an increase in suicidal ideation/attempts independent of depression in a population sample of adolescents. We analyzed data from the National Longitudinal Study of Adolescent Health, a longitudinal study of a nationally representative sample of adolescents in the United States (N = 9,970). Most chronic pain was related to suicide ideation/attempt both in the last year (odds ratio [OR] 1.3–2.1) and during the subsequent year (OR 1.2–1.8). After controlling for depressive symptoms, headaches (OR = 1.3 last year, OR = 1.2 subsequent year) and muscle aches (OR = 1.3 last year) remained associated with suicide ideation but not suicide attempt. These findings show that chronic pain in adolescence is a risk factor for suicide ide... The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5283191 Mon, 20 Jun 2011 04:00:00 +0100 5283191 Occurrence and Characteristics of Chronic Pain in a Community-Based Cohort of Indigent Adults Living With HIV Infection http://www.medworm.com/index.php?rid=5174527&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011005372%2Fabstract%3Frss%3Dyes This article presents epidemiological data showing that unrelieved chronic pain is a significant problem for indigent people living with HIV. Participants reported pain severity similar to those with metastatic cancer. Despite high rates of substance use disorders, approximately half received prescriptions for opioid analgesics, although few for long-acting agents. (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5174527 Sun, 19 Jun 2011 23:00:00 +0100 5174527 Topographical Pressure and Thermal Pain Sensitivity Mapping in Patients With Unilateral Lateral Epicondylalgia http://www.medworm.com/index.php?rid=5283192&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011005360%2Fabstract%3Frss%3Dyes Abstract: Our aim was to quantify spatial differences in pressure and thermal pain sensitivity maps between patients with unilateral lateral epicondylalgia (LE) and age- and sex-matched controls. Pressure (PPT), cold (CPT), and heat (HPT) pain thresholds were assessed over 12 points forming a 3 × 4 matrix (4 points in the superior part, 4 points in the middle, and 4 points in the lower part around the lateral epicondyle) bilaterally in 16 subjects with strictly unilateral LE and 16 age- and sex-matched controls in a blinded design. Topographical pain sensitivity maps to pressure and thermal stimulation over the elbow in patients with LE and healthy controls were calculated. A multilevel 3-way ANCOVA test was applied to detect differences in topographical maps between groups. Subjects with... The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5283192 Fri, 17 Jun 2011 04:00:00 +0100 5283192 Preservation of Acute Pain and Efferent Functions Following Intrathecal Resiniferatoxin-Induced Analgesia in Rats http://www.medworm.com/index.php?rid=5174526&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011005220%2Fabstract%3Frss%3Dyes Abstract: Resiniferatoxin (RTX) is a potent agonist of TRPV1, which possesses unique properties that can be utilized to treat certain modalities of pain. In the present study, systemic intraperitoneal (i.p.) administration of RTX resulted in a significant decrease in acute thermal pain sensitivity, whereas localized intrathecal (i.t.) administration had no effect on acute thermal pain sensitivity. Both i.p. and i.t. administration of RTX prevented TRPV1-induced nocifensive behavior and inflammatory thermal hypersensitivity. There were no alterations in mechanical sensitivity either by i.p. or i.t. administration of RTX. In spinal dorsal horn (L4-L6), TRPV1 and substance P immunoreactivity were abolished following i.p. and i.t. administration of RTX. In dorsal root ganglia (DRG), TRPV1 immu... The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5174526 Thu, 16 Jun 2011 23:00:00 +0100 5174526 Reciprocal Relationship Between Pain and Depression: A 12-Month Longitudinal Analysis in Primary Care http://www.medworm.com/index.php?rid=5174523&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011004871%2Fabstract%3Frss%3Dyes This study strengthens the evidence for a bidirectional and potentially causative influence of pain and depression on one another. A change in severity of either symptom predicts subsequent severity of the other symptom. Thus, recognition and management of both conditions may be warranted, particularly when treatment focused on 1 condition is not leading to an optimal response. (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5174523 Thu, 16 Jun 2011 23:00:00 +0100 5174523 Elevated Pain Sensitivity in Chronic Pain Patients at Risk for Opioid Misuse http://www.medworm.com/index.php?rid=5174522&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011004883%2Fabstract%3Frss%3Dyes This study employed quantitative sensory testing (QST) to evaluate pain responses in chronic spinal pain patients at low risk and high risk for opioid misuse, with risk classification based on scores on the Screener and Opioid Assessment for Patients with Pain-Revised (SOAPP-R). Patients were further subgrouped according to current use of prescription opioids. Of the 276 chronic pain patients tested, approximately 65% were taking opioids; a median split was used to further categorize these patients as being on lower or higher doses of opioids. The high-risk group (n = 161) reported higher levels of clinical pain, had lower pressure and thermal pain thresholds at multiple body sites, had lower heat pain tolerance, and rated repetitive mechanical stimuli as more painful relative to the low-r... The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5174522 Thu, 16 Jun 2011 23:00:00 +0100 5174522 Experimental Muscle Pain Challenges the Postural Stability During Quiet Stance and Unexpected Posture Perturbation http://www.medworm.com/index.php?rid=5095804&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011004858%2Fabstract%3Frss%3Dyes This article presents the acute responses to leg muscle pain on the postural control. This measure could potentially help clinicians who seek to assess how pain responses may contribute to patient’s postural control and stability during quiet standing and after recovering from unexpected perturbations. (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5095804 Thu, 16 Jun 2011 23:00:00 +0100 5095804 Involvement of Spinal Neurotrophin-3 in Electroacupuncture Analgesia and Inhibition of Spinal Glial Activation in Rat Model of Monoarthritis http://www.medworm.com/index.php?rid=5174524&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS152659001100486X%2Fabstract%3Frss%3Dyes Abstract: Although electroacupuncture (EA) has been proven to effectively relieve pain associated with arthritis, the underlying mechanism of EA analgesia requires further investigation. Here, the involvement of spinal neurotrophin-3 (NT-3) in EA’s analgesic effects on complete Freund’s adjuvant (CFA)-induced inflammatory pain was examined. The present study demonstrated that: 1) repeated EA stimulation of ipsilateral GB30 and GB34 acupoints remarkably suppressed CFA-induced hyperalgesia; 2) EA treatment markedly enhanced the upregulation of spinal NT-3 mRNA and protein levels following CFA injection; 3) antisense oligodeoxynucleotides (ODN) specifically against NT-3 intrathecally administered during EA treatment for 7 days significantly attenuated the EA analgesia; and 4) the suppres... The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5174524 Wed, 15 Jun 2011 23:00:00 +0100 5174524 Vibration-Induced Afferent Activity Augments Delayed Onset Muscle Allodynia http://www.medworm.com/index.php?rid=5095801&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011004767%2Fabstract%3Frss%3Dyes Abstract: Evidence suggests large diameter afferents, presumably in response to centrally mediated changes, augment the mechanical allodynia or hyperalgesia seen in delayed onset muscle soreness (DOMS) conditions. Healthy males aged 18 to 30 (n = 16) performed eccentric exercise eliciting DOMS in the tibialis anterior muscle of a randomly assigned exercised leg. The contralateral leg served as a control. Mechanosensitivity was assessed on the exercised and control legs prior to and 24 hours postexercise via pressure pain thresholds (PPTs). PPTs were assessed at the muscle site, and at a distant segmentally related site, either without vibration or with vibration concurrently applied to the distant muscle, segmentally related, or control extra-segmentally related site. Participants complete... The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5095801 Sun, 12 Jun 2011 23:00:00 +0100 5095801 Table of Contents http://www.medworm.com/index.php?rid=4902222&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011005979%2Fabstract%3Frss%3Dyes (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=4902222 Tue, 31 May 2011 23:00:00 +0100 4902222 Editorial Board http://www.medworm.com/index.php?rid=4902221&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011005967%2Fabstract%3Frss%3Dyes (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=4902221 Tue, 31 May 2011 23:00:00 +0100 4902221 Masthead http://www.medworm.com/index.php?rid=4902220&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011005955%2Fabstract%3Frss%3Dyes (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=4902220 Tue, 31 May 2011 23:00:00 +0100 4902220 Reply http://www.medworm.com/index.php?rid=4902219&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011005852%2Fabstract%3Frss%3Dyes We appreciate the attention Gourlay and Heit paid to the details of our paper and their significant contribution to risk management in pain care through the elucidation of universal precautions. As we consider the possible utility of abuse-resistant and abuse-deterrent formulations (ARFs and ADFs), it is useful to picture how substance-use disorders take hold. (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=4902219 Tue, 31 May 2011 23:00:00 +0100 4902219 Universal Precautions: It’s Not About the Molecule! http://www.medworm.com/index.php?rid=4902218&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011005530%2Fabstract%3Frss%3Dyes The recently published article by Webster and Fine on “Approaches to Improve Relief while Minimizing Opioid Abuse Liability” offers the reader an overview of the possible role of abuse resistant/deterrent drug delivery systems in the very complex world of prescription drug misuse, abuse, and diversion. Unfortunately, in our opinion, their use of the term “Universal Precautions” in this context may perpetuate the myth that risk management is largely about the molecule. (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=4902218 Tue, 31 May 2011 23:00:00 +0100 4902218 Development and Preliminary Testing of a Scale to Assess Pain-Related Fear in Children and Adolescents http://www.medworm.com/index.php?rid=5095796&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011000319%2Fabstract%3Frss%3Dyes This article presents a new measure of fear associated with pain in children and adolescents. This measure could potentially help researchers to gain a better understanding about the role of pain-related fear in children and adolescents and support clinical decision-making. (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5095796 Sun, 22 May 2011 23:00:00 +0100 5095796 Pain in HIV: An Evolving Epidemic http://www.medworm.com/index.php?rid=4902208&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011005232%2Fabstract%3Frss%3Dyes JG was a 46-year-old man with acquired immune deficiency syndrome (AIDS) proven to be refractory to antiretroviral therapy. He presented to the emergency room with severe oral pain and odynophagia developing over 2 weeks, limiting his nutritional intake significantly with 10 pounds of weight loss. Additional medical history was significant for seizures and a cerebrovascular accident (CVA) 4 years prior. On review of systems, he denied fevers, diarrhea, or skin lesions; however, he reported several months of painful tingling in both feet that was worsened when wearing socks and shoes. Medications on admission included sulfamethoxazole-trimethoprim, valacyclovir, azithromycin, fluconazole, as well as several antiretroviral agents. (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=4902208 Wed, 18 May 2011 23:00:00 +0100 4902208 Submission Form http://www.medworm.com/index.php?rid=4794743&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011005517%2Fabstract%3Frss%3Dyes (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=4794743 Sat, 30 Apr 2011 23:00:00 +0100 4794743 Instructions to Authors http://www.medworm.com/index.php?rid=4794742&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011005505%2Fabstract%3Frss%3Dyes (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=4794742 Sat, 30 Apr 2011 23:00:00 +0100 4794742 Table of Contents http://www.medworm.com/index.php?rid=4794741&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011005426%2Fabstract%3Frss%3Dyes (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=4794741 Sat, 30 Apr 2011 23:00:00 +0100 4794741 Editorial Board http://www.medworm.com/index.php?rid=4794740&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011005414%2Fabstract%3Frss%3Dyes (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=4794740 Sat, 30 Apr 2011 23:00:00 +0100 4794740 Masthead http://www.medworm.com/index.php?rid=4794739&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011005402%2Fabstract%3Frss%3Dyes (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=4794739 Sat, 30 Apr 2011 23:00:00 +0100 4794739 Prevalence and Characteristics of Pain in Patients With Chronic Obstructive Pulmonary Disease Compared to the Norwegian General Population http://www.medworm.com/index.php?rid=4794730&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590010008011%2Fabstract%3Frss%3Dyes Abstract: The purpose of this study was to evaluate the prevalence and characteristics of pain in patients with chronic obstructive pulmonary disease (COPD) compared to a sample from the Norwegian general population. This cross-sectional study evaluated 100 COPD patients with and without pain and 333 individuals from the Norwegian population with pain. After controlling for age and sex, a significantly higher percentage of patients with COPD (45%) reported pain than the general population (34%; P = .02). No differences were found in pain intensity scores, pain interference score, or number of pain locations between COPD patients and the general population. COPD patients reported moderate-to-severe pain located primarily in the chest, shoulders, neck, and thorax. For both groups, the most c... The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=4794730 Sat, 30 Apr 2011 23:00:00 +0100 4794730 Conditioned Place Preference Reveals Tonic Pain in an Animal Model of Central Pain http://www.medworm.com/index.php?rid=5095799&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011003956%2Fabstract%3Frss%3Dyes Abstract: A limitation of animal models of central pain is their inability to recapitulate all clinical characteristics of the human condition. Specifically, many animal models rely on reflexive measures of hypersensitivity and ignore, or cannot assess, spontaneous pain, the hallmark characteristic of central pain in humans. Here, we adopt a conditioned place preference paradigm to test if animals with lesions in the anterolateral quadrant of the spinal cord develop signs consistent with spontaneous pain. This paradigm relies on the fact that pain relief is rewarding to animals, and has been used previously to show that animals with peripheral nerve injury develop tonic pain. With the use of 2 analgesic treatments commonly used to treat patients with central pain (clonidine infusion and mo... The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5095799 Mon, 25 Apr 2011 23:00:00 +0100 5095799 Pain Characteristic Differences Between Subacute and Chronic Back Pain http://www.medworm.com/index.php?rid=4997446&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011000344%2Fabstract%3Frss%3Dyes Abstract: Back pain is commonly classified based on duration. There is currently limited information regarding differences in the clinical features of back pain between these duration-based groupings. Here, we compared the pain characteristics of patients with subacute (SBP; pain 6–16 weeks, n = 40) and chronic back pain (CBP; pain ≥1 year, n = 37) recruited from the general population. CBP patients reported significantly higher pain intensity on the Visual Analogue Scale (VAS) compared to SBP patients. Based on this finding, we investigated group differences and their dependence on VAS for the Beck Depression Inventory (BDI), sensory and affective dimensions of the McGill Pain Questionnaire (MPQ-S and MPQ-A), Neuropathic Pain Scale (NPS), and the variability of spontaneous pain. Corre... The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=4997446 Sun, 17 Apr 2011 23:00:00 +0100 4997446 Breast Cancer-Induced Bone Remodeling, Skeletal Pain, and Sprouting of Sensory Nerve Fibers http://www.medworm.com/index.php?rid=4902216&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011004159%2Fabstract%3Frss%3Dyes Abstract: Breast cancer metastasis to bone is frequently accompanied by pain. What remains unclear is why this pain tends to become more severe and difficult to control with disease progression. Here we test the hypothesis that with disease progression, sensory nerve fibers that innervate the breast cancer bearing bone undergo a pathological sprouting and reorganization, which in other nonmalignant pathologies has been shown to generate and maintain chronic pain. Injection of human breast cancer cells (MDA-MB-231-BO) into the femoral intramedullary space of female athymic nude mice induces sprouting of calcitonin gene-related peptide (CGRP+) sensory nerve fibers. Nearly all CGRP+ nerve fibers that undergo sprouting also coexpress tropomyosin receptor kinase A (TrkA+) and growth-associated ... The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=4902216 Sun, 17 Apr 2011 23:00:00 +0100 4902216 Transcranial DC Stimulation in Fibromyalgia: Optimized Cortical Target Supported by High-Resolution Computational Models http://www.medworm.com/index.php?rid=4794738&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011000289%2Fabstract%3Frss%3Dyes In this study we aimed to determine current distribution and short-term analgesic effects of transcranial direct current stimulation (tDCS) in fibromyalgia using different electrode montages. For each electrode montage, clinical effects were correlated with predictions of induced cortical current flow using magnetic resonance imaging–derived finite element method head model. Thirty patients were randomized into 5 groups (Cathodal-M1 [primary motor cortex], Cathodal-SO [supra-orbital area], Anodal-M1, Anodal-SO, and Sham) to receive tDCS application (2 mA, 20 minutes) using an extracephalic montage. Pain was measured using a visual numerical scale (VNS), pressure pain threshold (PPT), and a body diagram (BD) evaluating pain area. There was significant pain reduction in cathodal-SO and ano... The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=4794738 Sun, 17 Apr 2011 23:00:00 +0100 4794738 Evidence-Based Pediatric Pain Management in Emergency Departments of a Rural State http://www.medworm.com/index.php?rid=5095803&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011004184%2Fabstract%3Frss%3Dyes This study reveals that health professionals in rural settings are particularly in need of improving the use of recommended pediatric pain management practices. (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5095803 Tue, 12 Apr 2011 23:00:00 +0100 5095803 Hypoalgesia in Response to Transcutaneous Electrical Nerve Stimulation (TENS) Depends on Stimulation Intensity http://www.medworm.com/index.php?rid=5095806&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011004445%2Fabstract%3Frss%3Dyes This study investigated the dose response of different TENS intensities on experimentally induced pressure pain. One hundred and thirty TENS naïve healthy individuals (18–64 years old; 65 males, 65 females) were randomly allocated to 5 groups (n = 26 per group): Strong Non Painful TENS; Sensory Threshold TENS; Below Sensory Threshold TENS; No Current Placebo TENS; and Transient Placebo TENS. Active TENS (80 Hz) was applied to the forearm for 30 minutes. Transient Placebo TENS was applied for 42 seconds after which the current amplitude automatically reset to 0 mA. Pressure pain thresholds (PPT) were recorded from 2 points on the hand and forearm before and after TENS to measure hypoalgesia. There were significant differences between groups at both the hand and forearm (ANOVA; P = .005 a... The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5095806 Sun, 10 Apr 2011 23:00:00 +0100 5095806 The Contribution of Sympathetic Mechanisms to Postamputation Phantom and Residual Limb Pain: A Pilot Study http://www.medworm.com/index.php?rid=5095798&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011000460%2Fabstract%3Frss%3Dyes In this study, sympathetic blocks were performed on 17 major limb amputees refractory to treatment, including 2 placebo-controlled blocks done for bilateral amputations. One hour postinjection, mean RLP scores at rest declined from 5.2 (SD 2.8) to 2.8 (SD 2.6) (P = .0002), and PLP decreased from 5.3 (SD 3.1) to 2.3 (SD 2.1) (P = .0009). By 1 week, mean pain scores for RLP and PLP were 4.3 (SD 2.9) and 4.2 (SD 3.0), respectively. Overall, 8 of 16 (50%) patients experienced ≥50% reduction in RLP 1-hour postinjection, with the beneficial effects being maintained at 1 and 8 weeks in 4 and 1 patient(s), respectively. For PLP, 8 of 15 (53%) patients obtained ≥50% decrease in pain 1-hour postblock, with these numbers decreasing to 2 patients at both 1 and 8 weeks. In the 2 bilateral amputees ... The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5095798 Sun, 10 Apr 2011 23:00:00 +0100 5095798 Sensory Focusing Versus Distraction and Pain: Moderating Effects of Anxiety Sensitivity in Males and Females http://www.medworm.com/index.php?rid=5095797&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011000307%2Fabstract%3Frss%3Dyes This study highlights the importance of considering anxiety sensitivity and sex when examining the relative effectiveness of attentional pain coping strategies. This finding may be potentially beneficial to clinicians considering pain management interventions that include a cognitive or attentional component. (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=5095797 Sun, 10 Apr 2011 23:00:00 +0100 5095797 Further Validation of a Model of Fibromyalgia Syndrome in the Rat http://www.medworm.com/index.php?rid=4997448&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011000320%2Fabstract%3Frss%3Dyes In this study, we tested the hypothesis that our model also manifests symptoms of common comorbid diagnoses: irritable bowel syndrome, temporomandibular disorder, and anxiety. Both visceral sensitivity and cytokine hyperalgesia in masseter muscle were present in the stressed rats. Furthermore, in an established model of irritable bowel syndrome—water avoidance—we observed significant muscle hyperalgesia. Finally, using the elevated plus maze to assess for anxiety level, we observed a significantly higher anxiety level in sound stress-exposed rats. Thus, unpredictable sound stress produces a condition in the rat with several features—delayed onset visceral and temporomandibular hyperalgesia and increased anxiety, as well as cutaneous and muscle hyperalgesia—commonly found in patient... The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=4997448 Sun, 10 Apr 2011 23:00:00 +0100 4997448 Reliability and Validity of a Brief Method to Assess Nociceptive Flexion Reflex (NFR) Threshold http://www.medworm.com/index.php?rid=4997445&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011000253%2Fabstract%3Frss%3Dyes Abstract: The nociceptive flexion reflex (NFR) is a physiological tool to study spinal nociception. However, NFR assessment can take several minutes and expose participants to repeated suprathreshold stimulations. The 4 studies reported here assessed the reliability and validity of a brief method to assess NFR threshold that uses a single ascending series of stimulations (Peak 1 NFR), by comparing it to a well-validated method that uses 3 ascending/descending staircases of stimulations (Staircase NFR). Correlations between the NFR definitions were high, were on par with test-retest correlations of Staircase NFR, and were not affected by participant sex or chronic pain status. Results also indicated the test-retest reliabilities for the 2 definitions were similar. Using larger stimulus incr... The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=4997445 Sun, 10 Apr 2011 23:00:00 +0100 4997445 Patterns and Predictors of Health Service Utilization in Adolescents With Pain: Comparison Between a Community and a Clinical Pain Sample http://www.medworm.com/index.php?rid=4997441&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS152659001100006X%2Fabstract%3Frss%3Dyes This study describes healthcare utilization in a clinical chronic pain sample, and compares the patterns of service use of this group to a community sample with intermittent pain complaints. We also investigated demographic and clinical factors that predicted healthcare visits and medication use in the clinical sample. Data on 117 adolescents (aged 12–18; n = 59 clinical pain sample, n = 58 community) were collected. Caregivers and adolescents reported on sociodemographics, medical visits, current medications, pain, activity limitations, and depression. As hypothesized, the clinical pain sample had higher rates of healthcare consultation on all types of medical visits (general, specialty care, complementary medicine, mental health, OT/PT), and higher medication use compared to the commun... The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=4997441 Sun, 10 Apr 2011 23:00:00 +0100 4997441 The Orofacial Formalin Test in Mice Revisited—Effects of Formalin Concentration, Age, Morphine and Analysis Method http://www.medworm.com/index.php?rid=4902210&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590010008345%2Fabstract%3Frss%3Dyes Abstract: The orofacial formalin test is established in rats and was recently transferred to mice. The aim of this study was to determine the ideal formalin concentration for testing analgesic drugs, to examine alternatives for the assessment of nociceptive and non-nociceptive behavior as well as the effects of morphine and age on formalin-induced nociception. Formalin (.5, 1, 2.5, 5, 7.5, 10, and 15%) was injected into the vibrissa of mice. The cumulative nociceptive behavior was measured as well as nociceptive and non-nociceptive behavior based on a score that was recorded over a 5-second observation period once per minute. We also examined the effects of morphine on the nociceptive response induced by 2.5% formalin. Age-dependent differences were tested in the third part of the experime... The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=4902210 Sun, 10 Apr 2011 23:00:00 +0100 4902210 Synergistic Interaction Between Intrathecal Ginsenosides and Morphine on Formalin-Induced Nociception in Rats http://www.medworm.com/index.php?rid=4997444&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011000071%2Fabstract%3Frss%3Dyes This article concerns the antinociceptive activity of ginsenosides, which increases antinociception by morphine. Thus, a spinal combination of ginsenosides and morphine may be useful in the management of acute pain as well as facilitated state pain. (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=4997444 Sun, 03 Apr 2011 23:00:00 +0100 4997444 Topical High-Concentration (40%) Menthol—Somatosensory Profile of a Human Surrogate Pain Model http://www.medworm.com/index.php?rid=4997443&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011000265%2Fabstract%3Frss%3Dyes This study establishes the topical application of high-concentration 40% menthol as a useful stable model for studies of cold hyperalgesia and pinprick hyperalgesia in humans. The provided long-term data are important for psychophysical and pharmacological research in humans and provide us with insights on experimental cold and mechanical hyperalgesia. (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=4997443 Sun, 03 Apr 2011 23:00:00 +0100 4997443 Efficacy of Low-Dose Celecoxib in Patients With Acute Pain http://www.medworm.com/index.php?rid=4997442&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011000277%2Fabstract%3Frss%3Dyes Abstract: The sore throat pain model was used to evaluate single-dose effects of celecoxib 50 and 100 mg over 6 hours in the treatment of acute pharyngeal pain. Multiple-dose effects of 50-mg bid and 100 mg followed by 50 mg over 6 to 24 hours were also evaluated. Under double-blind, randomized, placebo-controlled conditions, 269 adults with confirmed acute pharyngitis rated throat pain intensity, throat soreness, difficulty swallowing, and sore throat pain relief over 24 hours. For the primary efficacy analysis (SPID2), patients receiving celecoxib 100 mg during the first 2 hours after the first dose had significantly higher mean scores than patients in the placebo group (P < .0003). Efficacy was also demonstrated for celecoxib 50 and 100 mg compared with placebo for all end points (inclu... The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=4997442 Sun, 03 Apr 2011 23:00:00 +0100 4997442 Modulation of Conditioned Fear, Fear-Conditioned Analgesia, and Brain Regional C-Fos Expression Following Administration of Muscimol into the Rat Basolateral Amygdala http://www.medworm.com/index.php?rid=4902217&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011000058%2Fabstract%3Frss%3Dyes In this study, we investigated the effects of intra-BLA administration of the GABAA receptor agonist muscimol on the expression of conditioned-fear, formalin-evoked nociception, and fear-conditioned analgesia in rats, and the associated alterations in brain regional expression of the immediate early gene product and marker of neuronal activity, c-Fos. Formalin-evoked nociceptive behavior, conditioned-fear and fear-conditioned analgesia were apparent in animals receiving intra-BLA saline. Intra-BLA muscimol suppressed fear behavior and prevented fear-conditioned analgesia, but had no significant effect on the expression of formalin-evoked nociception. The suppression of fear behavior by intra-BLA muscimol was associated with increased c-Fos expression in the central nucleus of the amygdala ... The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=4902217 Sun, 03 Apr 2011 23:00:00 +0100 4902217 Submission Form http://www.medworm.com/index.php?rid=4670017&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011004913%2Fabstract%3Frss%3Dyes (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=4670017 Thu, 31 Mar 2011 23:00:00 +0100 4670017 Instructions to Authors http://www.medworm.com/index.php?rid=4670016&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011004901%2Fabstract%3Frss%3Dyes (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=4670016 Thu, 31 Mar 2011 23:00:00 +0100 4670016 Table of Contents http://www.medworm.com/index.php?rid=4670015&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011004585%2Fabstract%3Frss%3Dyes (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=4670015 Thu, 31 Mar 2011 23:00:00 +0100 4670015 Editorial Board http://www.medworm.com/index.php?rid=4670014&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011004573%2Fabstract%3Frss%3Dyes (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=4670014 Thu, 31 Mar 2011 23:00:00 +0100 4670014 Masthead http://www.medworm.com/index.php?rid=4670013&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011004561%2Fabstract%3Frss%3Dyes (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=4670013 Thu, 31 Mar 2011 23:00:00 +0100 4670013 Erratum http://www.medworm.com/index.php?rid=4670012&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011003944%2Fabstract%3Frss%3Dyes In the January 2011 issue of The Journal of Pain, the article by Okifuji et al (Okifuji A, Bradshaw DH, Donaldson GW, Turk DC: Sequential analyses of daily symptoms in women with fibromyalgia syndrome. J Pain 12: 84-93, 2011) incorrectly listed one of the grant numbers. The grant number listed R01 AR40303 should have been listed as R01 R46303. (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=4670012 Thu, 31 Mar 2011 23:00:00 +0100 4670012 Persistent Pain After Breast Cancer Treatment: A Critical Review of Risk Factors and Strategies for Prevention http://www.medworm.com/index.php?rid=4997440&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590010008576%2Fabstract%3Frss%3Dyes Abstract: Chronic pain after breast cancer treatment is a major clinical problem, affecting 25 to 60% of patients. Development of chronic pain after breast cancer treatment, as well as other surgical procedures, involves a complex pathophysiology that involves pre-, intra- and post-operative factors. This review is a systematic analysis on methodology and evidence in research into persistent pain after breast cancer treatment during the period 1995 to 2010, in order to clarify the significance and relative role of potential risk factors. Literature was identified by a search in PubMed and OVID, as well as by obtaining relevant studies from a systematic review of reference lists. Sixty papers were identified, most of these being retrospective or questionnaires. Only 2 studies included quant... The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=4997440 Fri, 25 Mar 2011 00:00:00 +0100 4997440 Trajectories of Pain and Analgesics in Oncology Outpatients With Metastatic Bone Pain During Participation in a Psychoeducational Intervention Study to Improve Pain Management http://www.medworm.com/index.php?rid=4902212&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590010008552%2Fabstract%3Frss%3Dyes Abstract: A large number of oncology patients with bone metastasis report significant and often unrelieved pain that is associated with reduced quality of life and impaired functional status. Our research team previously assessed the efficacy of a tailored self-care psychoeducational intervention to improve pain management in these patients. Samplewide analyses demonstrated improvements in pain intensity and analgesic prescriptions. However, substantial interindividual variability was observed within the intervention group. In the current paper, hierarchical linear modeling (HLM) was used to determine factors that contributed to variability in pain intensity and analgesic prescription and intake in the sample of patients who participated in the intervention. Specifically, HLM analyses iden... The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=4902212 Wed, 23 Mar 2011 00:00:00 +0100 4902212 Adolescent Acceptance of Pain: Confirmatory Factor Analysis and Further Validation of the Chronic Pain Acceptance Questionnaire, Adolescent Version http://www.medworm.com/index.php?rid=4794736&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590010008242%2Fabstract%3Frss%3Dyes This article strengthens the psychometric support for a measure of chronic pain acceptance in adolescents. Acceptance-based treatment has been shown to reduce disability in preliminary research targeting adolescents with chronic pain; the CPAQ-A may be useful for assessing the degree to which acceptance-based approaches may be indicated for a given patient. (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=4794736 Wed, 23 Mar 2011 00:00:00 +0100 4794736 Subcutaneous Methylnaltrexone for Treatment of Opioid-Induced Constipation in Patients With Chronic, Nonmalignant Pain: A Randomized Controlled Study http://www.medworm.com/index.php?rid=4794732&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590010008333%2Fabstract%3Frss%3Dyes We present data demonstrating that subcutaneous methylnaltrexone 12 mg given once daily (QD) or every other day provides significant relief of OIC and was generally well tolerated in patients with chronic, nonmalignant pain. These results expand on prior effectiveness observed for the treatment of OIC in advanced illness patients to a broader population. (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=4794732 Wed, 23 Mar 2011 00:00:00 +0100 4794732 Parsimonious Collection of Pain Descriptors: Classification and Calibration by Pain Patients http://www.medworm.com/index.php?rid=4670004&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590010007984%2Fabstract%3Frss%3Dyes This study found that in the English language, 36 words (classified into 12 subcategories) can be efficiently used to describe pain. These words can also be reliably ordered in terms of implied pain intensity. This has implications for the qualitative and quantitative assessment of pain patients. (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=4670004 Thu, 17 Mar 2011 00:00:00 +0100 4670004 Table of Contents http://www.medworm.com/index.php?rid=4592218&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011004007%2Fabstract%3Frss%3Dyes (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=4592218 Tue, 01 Mar 2011 00:00:00 +0100 4592218 Editorial Board http://www.medworm.com/index.php?rid=4592217&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011003993%2Fabstract%3Frss%3Dyes (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=4592217 Tue, 01 Mar 2011 00:00:00 +0100 4592217 Masthead http://www.medworm.com/index.php?rid=4592216&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590011003981%2Fabstract%3Frss%3Dyes (Source: The Journal of Pain) The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=4592216 Tue, 01 Mar 2011 00:00:00 +0100 4592216 The Fear of Pain Questionnaire (FOPQ): Assessment of Pain-Related Fear Among Children and Adolescents With Chronic Pain http://www.medworm.com/index.php?rid=4902214&cid=s_38522_173_f&fid=38522&url=http%3A%2F%2Fwww.jpain.org%2Farticle%2FPIIS1526590010008606%2Fabstract%3Frss%3Dyes Abstract: An important construct in understanding pain-related disability is pain-related fear. Heightened pain-related fear may result in behavioral avoidance leading to disuse, disability, and depression; whereas confrontation of avoided activities may result in a reduction of fear over time and reengagement with activities of daily living. Although there are several measures to assess pain-related fear among adults with chronic pain, none exist for children and adolescents. The aim of the current study was to develop a new tool to assess avoidance and fear of pain with pediatric chronic pain patients: the Fear of Pain Questionnaire, child report (FOPQ-C), and Fear of Pain Questionnaire, parent proxy report (FOPQ-P). After initial pilot testing, the FOPQ-C and FOPQ-P were administered to... The Journal of Pain journals http://www.medworm.com/rss/comments.php?id=4902214 Mon, 28 Feb 2011 00:00:00 +0100 4902214