MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'The Korean Journal of Laboratory Medicine' source. Fri, 19 Mar 2010 17:56:05 +0100 http://www.medworm.com/index.php?rid=3330451&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20197715%26dopt%3DAbstract CONCLUSIONS: The frequency of TEL/AML1 and additional genetic changes in TEL and AML1 is higher than previous studies in Korean children, and in close agreement with usually reported one, 20-25%. TEL/AML1-positive group showed a tendency toward better prognosis. Further study is needed to clarify the prognostic significance of additional changes in TEL and AML1 based on a large sample size. PMID: 20197715 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=3330451 Mon, 01 Feb 2010 00:00:00 +0100 3330451 http://www.medworm.com/index.php?rid=3330450&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20197716%26dopt%3DAbstract CONCLUSIONS: The 3 full-range CRP tests, by virtue of their wide AMR, may be used for the detection of acute inflammation as well as for the assessment of cardiovascular risk. N-CRP and I-CRP may be more useful than P-CRP for determining the CRP concentration, especially for the detection of concentrations close to the lower or upper limit of the analytical range, without the need for repetition of the test. PMID: 20197716 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=3330450 Mon, 01 Feb 2010 00:00:00 +0100 3330450 http://www.medworm.com/index.php?rid=3330449&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20197717%26dopt%3DAbstract Authors: Im M, Kim M, Lee JK, Chang YH, Lee DY, Hong SI, Lee YY, Hong YJ Thiazolidinediones (TZD), which are widely used as insulin sensitizers, and fibrates, which are lipid-lowering drugs, are used in the treatment of dyslipidemia that commonly accompanies diabetes. Several reports suggest elevated levels of high-density lipoprotein (HDL) cholesterol, but the paradoxical reduction of HDL cholesterol level during single or combined TZD and fibrate therapies has been occasionally reported. Herein, we report a case of paradoxical decrease in HDL cholesterol and apolipoprotein A-1 levels during rosiglitazone and fenofibrate treatment for the first time in Korea. The patient was a 56-yr-old man presenting with type 2 diabetes mellitus and dyslipidemia. His HDL cholesterol and apolipoprote... The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=3330449 Mon, 01 Feb 2010 00:00:00 +0100 3330449 http://www.medworm.com/index.php?rid=3330448&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20197718%26dopt%3DAbstract CONCLUSIONS: Silver-coated or silver-impregnated wound dressings can be used for treating MRSAinfected wounds. Considering its superior efficacy in comparison to the efficacies of other silver-coated or silver-impregnated wound dressings, Acticoat(R) should be preferentially used for the treatment of MRSA-infected skin wounds. PMID: 20197718 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=3330448 Mon, 01 Feb 2010 00:00:00 +0100 3330448 http://www.medworm.com/index.php?rid=3330446&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20197719%26dopt%3DAbstract CONCLUSIONS: Legionella spp. isolates from Korea and Japan were most susceptible to gatifloxacin. Azithromycin, clarithromycin, ciprofloxacin, and gemifloxacin were also effective for treating legionellosis. PMID: 20197719 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=3330446 Mon, 01 Feb 2010 00:00:00 +0100 3330446 http://www.medworm.com/index.php?rid=3330444&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20197720%26dopt%3DAbstract We report a case of cat scratch disease in an 8-yr-old girl who presented with fever and enlargement of both axillary lymph nodes. Both aerobic and anaerobic cultures of the lymph node aspirate were negative for microbial growth. Gram staining and Warthin-Starry silver staining did not reveal any organism. Purified DNA from the PCR-amplicon of the 16S-23S rRNA intergenic region was sequenced and showed 99.7% identity with the corresponding sequence of Bartonella henselae strain Houston-1. Our findings suggest that the internal transcribed spacer is a reliable region for PCR identification of Bartonella species. In patients with lymphadenitis, a history of contact with cats or dogs necessitates the use of diagnostic approaches that employ not only the conventional staining and culture but a... The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=3330444 Mon, 01 Feb 2010 00:00:00 +0100 3330444 http://www.medworm.com/index.php?rid=3330443&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20197721%26dopt%3DAbstract CONCLUSIONS: LAC was the most common antibody detected in Korean SLE patients and is shown to have a significant association with the presence of venous/arterial thrombosis. The measurement of LAC may be clinically useful in identifying patients with SLE who are at a high risk for venous/arterial thrombosis. PMID: 20197721 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=3330443 Mon, 01 Feb 2010 00:00:00 +0100 3330443 http://www.medworm.com/index.php?rid=3330442&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20197722%26dopt%3DAbstract CONCLUSIONS: Nanofiltration would be an effective method for the elimination of B19V and HAV. It may be used as a substitute for NAT screening of these viruses in source plasma to ensure safety of plasma derivatives in Korea. PMID: 20197722 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=3330442 Mon, 01 Feb 2010 00:00:00 +0100 3330442 http://www.medworm.com/index.php?rid=3330441&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20197723%26dopt%3DAbstract CONCLUSIONS: Le/Le, Le/le(59,508), and Le/le(59,1067) are frequent Lewis genotypes in Koreans. Because serum CA 19-9 levels are significantly influenced by the Lewis/Secretor genotypes, caution is suggested when interpreting the serum CA 19-9 levels. PMID: 20197723 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=3330441 Mon, 01 Feb 2010 00:00:00 +0100 3330441 http://www.medworm.com/index.php?rid=3330440&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20197724%26dopt%3DAbstract CONCLUSIONS: The prevalence of B19V DNA in Korean blood donors was not high and most donors also possessed neutralizing anti-B19V antibodies. Thus, the implementation of a B19V screening test for Korean blood donors does not appear to be imperative. PMID: 20197724 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=3330440 Mon, 01 Feb 2010 00:00:00 +0100 3330440 http://www.medworm.com/index.php?rid=3330436&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20197725%26dopt%3DAbstract Authors: Cho D, Shin DJ, Yazer MH, Ihm CH, Hur YM, Kee SJ, Kim SH, Shin MG, Shin JH, Suh SP, Ryang DW The B3 phenotype is the most common B subtype in Korea. The B305 allele (425 T>C, M142T) was first reported in 2 Chinese individuals; however, it has not yet been reported in the Koreans, and the impact of the M142T mutation on the expression of the B3 phenotype has also not been studied. To resolve an ABO discrepancy between a group O neonate and her group O father and A(1)B(3) mother, blood samples from these individuals and other family members were referred to our laboratory for ABO gene analysis. The B305 allele was discovered in the neonate (B305/O01), her mother (A102/ B305), and her maternal aunt (B305/O02), while her father was typed as O01/O02. Transient transfection exper... The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=3330436 Mon, 01 Feb 2010 00:00:00 +0100 3330436 http://www.medworm.com/index.php?rid=3330434&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20197726%26dopt%3DAbstract CONCLUSIONS: The novel 4.0-Mb 3q29 microdeletion found in the twins suggested the occurrence of genomic rearrangement mediated by mechanisms other than nonallelic homologous recombination. Molecular genetic and functional studies are required to elucidate the contribution of each gene to a specific phenotype. PMID: 20197726 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=3330434 Mon, 01 Feb 2010 00:00:00 +0100 3330434 http://www.medworm.com/index.php?rid=3330419&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20197727%26dopt%3DAbstract CONCLUSIONS: Our results suggest that ESR1 gene polymorphisms may be associated with dysmenorrhea. PMID: 20197727 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=3330419 Mon, 01 Feb 2010 00:00:00 +0100 3330419 http://www.medworm.com/index.php?rid=3330413&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20197728%26dopt%3DAbstract Authors: Woo KS, Kim JE, Kim KE, Kim MJ, Yoo JH, Ahn HS, Shaffer LG, Han JY Deletions of chromosome 6q, particularly in the proximal region, are relatively rare. Here, we report on a de novo interstitial deletion of (6)(q13q16.2) in a girl with facial dysmorphism, congenital hip dislocation, porencephaly, and brain atrophy. Array comparative genomic hybridization analysis showed arr 6q13q16.2(73,378,824?99,824,130), demonstrating higher resolution than the conventional cytogenetic findings, del(6)(q12q15). The clinical data were analyzed and compared with those of similar patients previously reported in the literature. PMID: 20197728 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=3330413 Mon, 01 Feb 2010 00:00:00 +0100 3330413 http://www.medworm.com/index.php?rid=3330412&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20197729%26dopt%3DAbstract Authors: Mun SJ, Cho EH, Chey MJ, Shim GH, Shin BM, Lee RK, Ko JK, Yoo SJ Pericentric inversion of chromosome 4 can give rise to 2 alternate recombinant (rec) chromosomesby duplication or deletion of 4p. The deletion of distal 4p manifests as Wolf-Hirschhorn syndrome (WHS). Here, we report the molecular cytogenetic findings and clinical manifestations observed in an infant with 46,XX,rec(4)dup(4q)inv(4)(p16q31.3)pat. The infant was delivered by Cesarean section at the 33rd week of gestation because pleural effusion and polyhydramnios were detected on ultrasonography. At birth, the infant showed no malformation or dysfunction, except for a preauricular skin tag. Array comparative genomic hybridization analysis of neonatal peripheral blood samples showed a gain of 38 Mb on 4q31.3-qter an... The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=3330412 Mon, 01 Feb 2010 00:00:00 +0100 3330412 http://www.medworm.com/index.php?rid=3330411&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20197730%26dopt%3DAbstract Authors: Yoon S, Lee CH, Lee KA Determination of the copy number of the survival motor neuron (SMN) gene is important for detecting spinal muscular atrophy (SMA) carriers and compound heterozygous patients. Multiplex ligationdependent probe amplification (MLPA) assay is a simple and efficient technique used for detecting variations in the copy numbers of different genes. Race- and ethnicity-based variation in the SMA carrier frequency and the '2+0' genotype of SMN1 are important factors that should be considered when estimating the risk of being an SMA carrier. Since SMN2 plays a disease-modifying role, accurate determination of SMN2 copy numbers in SMA patients can serve as a useful prognostic tool. Therefore, information on the SMN2 genotype distributions in normal populations will b... The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=3330411 Mon, 01 Feb 2010 00:00:00 +0100 3330411 http://www.medworm.com/index.php?rid=3143048&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20046078%26dopt%3DAbstract CONCLUSIONS: The CD7 antigen loss was frequently observed in our series of ANKL patients. In conjunction with the cytogenetic findings, this characteristic immunophenotypic finding can serve as a reliable marker for the timely diagnosis of ANKL. Therefore, immunophenotypic analysis of CD7 expression should be included in the diagnosis of NK cell neoplasms. PMID: 20046078 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=3143048 Tue, 01 Dec 2009 00:00:00 +0100 3143048 http://www.medworm.com/index.php?rid=3143047&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20046079%26dopt%3DAbstract CONCLUSIONS: Addition of SCT to dRVVT can improve the detection sensitivity of thrombosis in LA test. And the high normalized LA ratio of SCT may be a useful parameter for detection of recurrent abortion. PMID: 20046079 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=3143047 Tue, 01 Dec 2009 00:00:00 +0100 3143047 http://www.medworm.com/index.php?rid=3143046&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20046080%26dopt%3DAbstract CONCLUSIONS: The platelet counts and platelet indices are useful for the differential diagnosis of thrombocytosis. The plateletcrit and LPLT are particularly useful for the diagnosis of ET when the platelet count is markedly increased. PMID: 20046080 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=3143046 Tue, 01 Dec 2009 00:00:00 +0100 3143046 http://www.medworm.com/index.php?rid=3143045&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20046081%26dopt%3DAbstract Authors: Im M, Lee JK, Lee DY, Hong YJ, Hong SI, Kang HJ, Chang YH Tetraploidy or near-tetraploidy is a rare cytogenetic abnormality found in AML, and is divided into primary and secondary forms. The secondary tetraploidy or near-tetraploidy found in AML is known to be specifically associated with t(8;21). In this case report, FISH analysis detected RUNX1-RUNX1T1 gene rearrangement in the absence of cytogenetic abnormality of t(8;21), which suggests the presence of unvailed t(8;21). This is the first case report of tetraploidy or near-tetraploidy AML with cryptic RUNX1/RUNX1T1 in Korea. Although the prognosis of tetraploidy or near- tetraploidy with t(8;21) is known to be poor, this patient shows a relatively good clinical course compared to other reported cases. PMID: 20046081 [Pu... The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=3143045 Tue, 01 Dec 2009 00:00:00 +0100 3143045 http://www.medworm.com/index.php?rid=3143044&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20046082%26dopt%3DAbstract CONCLUSIONS: There was a significant correlation between warfarin dose and plasma warfarin concentrations in Korean patients with atrial fibrillation. Hence, plasma warfarin monitoring can help determine dose adjustments and improve our understanding of individual patient response to warfarin treatment. PMID: 20046082 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=3143044 Tue, 01 Dec 2009 00:00:00 +0100 3143044 http://www.medworm.com/index.php?rid=3143043&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20046083%26dopt%3DAbstract CONCLUSIONS: The negative bias associated with the use of NaF tubes may significantly affect the prevalence of diabetes. Serum separation and refrigeration within 30 min after venous sampling is recommended over NaF method, not only to minimize the preanalytical impact on detecting diabetes but also to reduce sample volume and number of tubes. PMID: 20046083 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=3143043 Tue, 01 Dec 2009 00:00:00 +0100 3143043 http://www.medworm.com/index.php?rid=3143042&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20046084%26dopt%3DAbstract CONCLUSIONS: The diagnostic utility of PCT is superior to that of CRP for the patients with blood culture-positive sepsis. PCT seems to be reliable for sepsis diagnosis, and may provide useful information for the critically ill patients. PMID: 20046084 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=3143042 Tue, 01 Dec 2009 00:00:00 +0100 3143042 http://www.medworm.com/index.php?rid=3143041&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20046085%26dopt%3DAbstract In conclusion, a patient can be inferred to have an Hb variant if the HbA1c concentration is abnormally high or low or if there is a discrepancy between the results obtained using different methods, and if the clinical status of the patient suggests the presence of abnormal Hb. Subsequently, the HbA1c values can be determined by methods based on different principles. PMID: 20046085 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=3143041 Tue, 01 Dec 2009 00:00:00 +0100 3143041 http://www.medworm.com/index.php?rid=3143040&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20046086%26dopt%3DAbstract CONCLUSIONS: The aac(6')-Ib-cr variants were widespread and showed significant relation to the high-level quinolone and aminoglycoside resistance in ESBL-producing E. coli and K. pneumoniae. PMID: 20046086 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=3143040 Tue, 01 Dec 2009 00:00:00 +0100 3143040 http://www.medworm.com/index.php?rid=3143039&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20046087%26dopt%3DAbstract CONCLUSIONS: The seroprevalence of HAV antibody among HCW in the age groups of 20's and 30's in a Korean hospital was not higher than that of non-HCW populations, and the seropositivity increased with increasing age. Further studies are needed for the age-specific strategy for vaccination, considering the increased risk of exposure in HCW to HAV infection in hospital environment with the increase of symptomatic patients with HAV. PMID: 20046087 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=3143039 Tue, 01 Dec 2009 00:00:00 +0100 3143039 http://www.medworm.com/index.php?rid=3143038&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20046088%26dopt%3DAbstract CONCLUSIONS: Maternal primary CMV infection was not detected in any of the pregnant women included in this study cohort. CMV IgG avidity test enabled the identification of women who were at a low risk of transmitting CMV infection and provided informative for subsequent pregnancy outcomes. Compared to previous studies, the seroprevalence of CMV IgG antibody across pregnant Korean women remained unchanged. PMID: 20046088 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=3143038 Tue, 01 Dec 2009 00:00:00 +0100 3143038 http://www.medworm.com/index.php?rid=3143037&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20046089%26dopt%3DAbstract Conclusion: In accordance with a decreasing sero-positivity of anti-HAV total, the prevalence of acute hepatitis A virus infection has been considerably increased during the recent four years in the age groups of >/= 21 yr. The results of this study could be used effectively as a basic data for establishing effective preventive measures for hepatitis A including vaccination in these susceptible age groups. PMID: 20046089 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=3143037 Tue, 01 Dec 2009 00:00:00 +0100 3143037 http://www.medworm.com/index.php?rid=3143036&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20046090%26dopt%3DAbstract CONCLUSIONS: The Koreans in the survey had a tendency of positive thinking about blood transfusions, and previous transfusion experiences appear to decrease the fear about transfusions. These results will be useful in understanding how Koreans think about the risks associated with transfusions. PMID: 20046090 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=3143036 Tue, 01 Dec 2009 00:00:00 +0100 3143036 http://www.medworm.com/index.php?rid=3143035&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20046091%26dopt%3DAbstract We report a case of a patient who developed DIIHA caused by 2 drugs. The patient's serum exhibited agglutination of ceftizoxime- or sulbactam-coated red blood cells (RBCs; via a drug-adsorption mechanism) and of uncoated RBCs in the presence of sulbactam (via an immune-complex mechanism). Although ceftizoxime is known to exhibit a positive reaction by an immune-complex method with or without reactivity with drug-coated RBCs, this patient's antibodies were reactive only against drug-coated RBCs. On the other hand, sulbactam, which is known to cause hemolytic anemia by nonimmunologic protein adsorption, exhibited positive reactions in tests with both drug-coated RBCs and in the presence of sulbactam. This is the first report of DIIHA due to a sulbactam-cefoperazone combination and the fourth... The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=3143035 Tue, 01 Dec 2009 00:00:00 +0100 3143035 http://www.medworm.com/index.php?rid=3143034&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20046092%26dopt%3DAbstract We report an experience of successful ABO-incompatible kidney transplantation using plasmapheresis and rituximab. The patient was a 32-yr-old female suffering from chronic renal failure, and her blood type was O, Rh+. The donor was her husband, and his blood type was B, Rh+. A combination therapy including 5 times of plasmapheresis starting from 10 days before transplantation with 2-day interval, intravenous gammaglobulin, rituximab at 2 weeks before transplantation and potent immunosuppression successfully decreased the titers of anti-A and anti-B antibodies to 1:2 and 1:1, respectively. The kidney transplantation was successful without any sign of hyperacute or acute rejection. PMID: 20046092 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=3143034 Tue, 01 Dec 2009 00:00:00 +0100 3143034 http://www.medworm.com/index.php?rid=3143033&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20046093%26dopt%3DAbstract CONCLUSIONS: In summary, both real-time PCR assays for HLA-B27 were fast, reliable, well-adapted for routine laboratory testing, and attractive alternatives to the conventional PCR-SSP method. PMID: 20046093 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=3143033 Tue, 01 Dec 2009 00:00:00 +0100 3143033 http://www.medworm.com/index.php?rid=3143032&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20046094%26dopt%3DAbstract CONCLUSIONS: Our results suggest that RT-PCR ELISA developed in this study could be an alternative diagnostic method for the detection of enteroviral genome with high sensitivity and specificity. PMID: 20046094 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=3143032 Tue, 01 Dec 2009 00:00:00 +0100 3143032 http://www.medworm.com/index.php?rid=2968345&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19893343%26dopt%3DAbstract CONCLUSIONS: FISH analysis as a profile test detected additional genetic aberrations in a significant proportion of acute leukemia, and was effective especially in detecting cryptic translocations, submicroscopic deletions and complex karyotypes. Our study supports the need to incorporate FISH profile test at initial work up in acute leukemia. PMID: 19893343 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2968345 Thu, 01 Oct 2009 00:00:00 +0100 2968345 http://www.medworm.com/index.php?rid=2968344&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19893344%26dopt%3DAbstract We report a case of morphologically microgranular acute promyelocytic leukemia with PML/RARA fusion transcripts demonstrated by reverse transcriptase-PCR and cDNA sequencing, and no PML/RARA fusion detected by karyotype and FISH analyses. Karyotype was 47,XX,+8[19]/46,XX[1]. Although the newer FISH probes provide more accurate detections of t(15;17), it would be necessary to perform other molecular tests to further identify the masked PML/RARA fusions. PMID: 19893344 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2968344 Thu, 01 Oct 2009 00:00:00 +0100 2968344 http://www.medworm.com/index.php?rid=2968343&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19893345%26dopt%3DAbstract We report a case of light chain deposition disease in a 59-yr-old female showing deposition of monoclonal light chain in the kidney and bone marrow accompanied with a schistocytosis, the morphologic finding of microangiopathic hemolytic anemia. The immunofluorescence examination of the kidney revealed strongly stained kappa-light chain deposits on the glomerular mesangium and capillary wall, tubules, and vessel wall. The electron microscopy demonstrated electron-dense deposits on the glomerular basement membrane and mesangium. Anemia was observed with schistocytosis and Howell-Jolly body in the peripheral blood smears. The immunohistochemical examination of the bone marrow showed the presence of kappa-light chain deposits in scattered plasma cells and thickened vessel wall in the absence o... The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2968343 Thu, 01 Oct 2009 00:00:00 +0100 2968343 http://www.medworm.com/index.php?rid=2968342&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19893346%26dopt%3DAbstract We report here 2 AML patients with t(16;21)(p11;q22), proved by conventional cytogenetics and/or reverse transcription (RT)-PCR. Erythrophagocytosis by leukemic blasts was observed in both of the cases. One patient was a 24 yr-old male with acute myelomonocytic leukemia. His karyotype was 46,XY,t(16;21)(p11;q22),del(18)(p11.2) and RT-PCR revealed the TLS/FUS-ERG fusion transcripts. Although he received allogeneic peripheral blood stem cell transplantation after the first remission, he died 9 months after the initial diagnosis due to relapse of the disease and graft-versus-host disease. The other patient was a 72 yr-old male with acute myeloid leukemia without maturation. His karyotype was 45,XY,-16,add(21)(q22) and the presence of t(16;21)(p11;q22) was detected by RT-PCR. He was transferre... The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2968342 Thu, 01 Oct 2009 00:00:00 +0100 2968342 http://www.medworm.com/index.php?rid=2968341&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19893347%26dopt%3DAbstract Authors: Song MJ, Kim HJ, Ko YH, Kim SH The immunophenotypic profile of hematological malignancies is usually consistent among different sites of involvement; this consistency allows reliable diagnosis from peripheral blood, bone marrow, or lymph node, especially in cases of acute leukemia. Although in a minority of lymphoma patients, two or more different populations with discordant immunophenotypes have been described, either at the same or distinct sites. Here, we report two Korean patients with acute leukemia where the results of immunophenotypic analysis of the bone marrow specimen were different from those of immunohistochemical studies of a biopsy sample of a cervical lymph node, particularly with respect to myeloperoxidase and CD3. The clinical significance of the immunophenoty... The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2968341 Thu, 01 Oct 2009 00:00:00 +0100 2968341 http://www.medworm.com/index.php?rid=2968340&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19893348%26dopt%3DAbstract We report three rare cases of concurrent bone marrow involvement of LCH and B-lineage lymphoid proliferation, which strongly suggest lymphoid malignancy. Further, clonal changes should be studied to elucidate the common pathogenic mechanism between the two diseases. PMID: 19893348 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2968340 Thu, 01 Oct 2009 00:00:00 +0100 2968340 http://www.medworm.com/index.php?rid=2968339&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19893349%26dopt%3DAbstract CONCLUSIONS: The claimed performance characteristic of Lucica GA-L were verified. WMG were better reflected by GA rather than HbA1c in patients on hemodialysis. PMID: 19893349 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2968339 Thu, 01 Oct 2009 00:00:00 +0100 2968339 http://www.medworm.com/index.php?rid=2968338&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19893350%26dopt%3DAbstract CONCLUSIONS: The imprecision, linearity, detection limits, interference and correlation of Tac-CM with ACMIA were suitable for clinical use. Tac-CM with ACMIA could reduce turn around time and help clinicians to manage transplant patients on immunosuppressant therapy. PMID: 19893350 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2968338 Thu, 01 Oct 2009 00:00:00 +0100 2968338 http://www.medworm.com/index.php?rid=2968337&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19893351%26dopt%3DAbstract CONCLUSIONS: This study showed that SureStep Flexx can provide reliable results for patients and clinicians to manage the diabetes mellitus, satisfying the ISO15197 criteria. PMID: 19893351 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2968337 Thu, 01 Oct 2009 00:00:00 +0100 2968337 http://www.medworm.com/index.php?rid=2968336&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19893352%26dopt%3DAbstract CONCLUSIONS: The Piccolo xpress Chemistry Analyzer can analyze multiple analytes with a minimal amount of whole blood in a short time. It showed an acceptable performance for precision, linearity and comparison with central laboratory analyzer. It can be useful as a screening tests modality in mobile clinics, ambulances, and field clinics for military use, and for pediatric patients from whom enough sample volume is difficult to obtain. PMID: 19893352 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2968336 Thu, 01 Oct 2009 00:00:00 +0100 2968336 http://www.medworm.com/index.php?rid=2968335&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19893353%26dopt%3DAbstract CONCLUSIONS: GeneOhm MRSA PCR assay showed a relatively high negative predictive value. However, its low specificity and frequent occurrence of unresolved results would be problematic in the endemic areas with a high prevalence of MRSA. PMID: 19893353 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2968335 Thu, 01 Oct 2009 00:00:00 +0100 2968335 http://www.medworm.com/index.php?rid=2968334&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19893354%26dopt%3DAbstract CONCLUSIONS: The combination-disk test with BA is a simple, efficient, and interpretable test that can be applicable in clinical laboratories involved in the detection of PABLs in clinical isolates of E. coli, K. pneumoniae, and P. mirabilis. PMID: 19893354 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2968334 Thu, 01 Oct 2009 00:00:00 +0100 2968334 http://www.medworm.com/index.php?rid=2968333&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19893355%26dopt%3DAbstract CONCLUSIONS: Detection of mutations in the katG codon 315, the inhA regulatory region, and the hot-spot region of rpoB would be useful for rapid detection of INH and RIF resistance in Korea. PMID: 19893355 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2968333 Thu, 01 Oct 2009 00:00:00 +0100 2968333 http://www.medworm.com/index.php?rid=2968332&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19893356%26dopt%3DAbstract Authors: Lee KH, Song W, Jeong SH, Choi KY, Yoon HS, Park MJ A clinical isolate of Salmonella enterica serotype Enteritidis in Korea was found to produce the extended-spectrum beta-lactamase CTX-M-15. The isolate was recovered in 2008 from the stool of a 3-yr-old boy with gastroenteritis. This isolate was found to be resistant to multiple drugs, including ampicillin, piperacillin, cefotaxime, ceftazidime, cefepime, and aztreonam. The resistance to cefotaxime was transferred by conjugation to recipient Escherichia coli J53. The patient was eventually successfully treated with trimethoprim-sulfamethoxazole. This is the first report of the bla (CTX-M-15) gene in S. enterica serotype Enteritidis in Korea. PMID: 19893356 [PubMed - in process] (Source: The Korean Journal of Laboratory Me... The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2968332 Thu, 01 Oct 2009 00:00:00 +0100 2968332 http://www.medworm.com/index.php?rid=2968331&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19893357%26dopt%3DAbstract CONCLUSIONS: Since Polycheck Allergy showed similar or superior result to the others, it can be used for the detection of allergen specific IgE antibodies. PMID: 19893357 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2968331 Thu, 01 Oct 2009 00:00:00 +0100 2968331 http://www.medworm.com/index.php?rid=2968330&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19893358%26dopt%3DAbstract CONCLUSIONS: Different methods used to detect HLA antibodies showed discrepant results. As the Luminex method was more sensitive than ELISA for the detection of HLA antibodies, it can be used as a routine test in the transplantation laboratory. PMID: 19893358 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2968330 Thu, 01 Oct 2009 00:00:00 +0100 2968330 http://www.medworm.com/index.php?rid=2968329&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19893359%26dopt%3DAbstract CONCLUSIONS: Effective post-transfusion platelet increment using HLA crossmatch-compatible donors was attained in patients with platelet refractoriness due to HLA antibodies, and this method can be used effectively where HLA-typed platelet donor registry is not available. PMID: 19893359 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2968329 Thu, 01 Oct 2009 00:00:00 +0100 2968329 http://www.medworm.com/index.php?rid=2767560&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19726886%26dopt%3DAbstract CONCLUSIONS: Putative pathogenetic T cell clones were detected in most of AA patients in the current study. T cell clonality assay would be useful for investigating the pathophysiology of acquired AA. PMID: 19726886 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2767560 Fri, 31 Jul 2009 23:00:00 +0100 2767560 http://www.medworm.com/index.php?rid=2767559&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19726887%26dopt%3DAbstract In this study, we serially monitored chimerism status by short tandem repeat-based PCR in nucleated cells (NC), T cells and natural killer (NK) cells after myeloablative allogeneic stem cell transplantation (SCT). Four patients with myeloid malignancies showed discrepant chimerism results among those three fractions. Three patients had mixed chimerism (MC) of donor/host T cells at a time point around the onset of chronic graft-versus-host disease (GVHD). In two patients with disease relapse, MC of NK cells preceded a morphological relapse or NK cells showed a higher percentage of patient cells compared to NC. Therefore, our study shows that chimerism analysis in lineage-specific cells might be useful in predicting clinical outcome after allogeneic SCT in certain patients. PMID: 1972688... The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2767559 Fri, 31 Jul 2009 23:00:00 +0100 2767559 http://www.medworm.com/index.php?rid=2767558&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19726888%26dopt%3DAbstract We describe a case of histiocytic sarcoma diagnosed by bone marrow biopsy. A 64-yr-old male was admitted for fever and weight loss that persisted for 8 months. The patient died undiagnosed on the 7th hospitalization day. A bone marrow biopsy performed just before the patient's death revealed diffuse proliferation of large pleomorphic neoplastic cells with large, round to oval nuclei, vesicular chromatin, and abundant foamy cytoplasm. These cells were positive for histiocytic markers, CD68, lysozyme, CD21, and S-100 protein, but negative for B-cell, T/NK-cell, and epithelial cell markers, thus confirming the presence of histiocytic sarcoma. PMID: 19726888 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2767558 Fri, 31 Jul 2009 23:00:00 +0100 2767558 http://www.medworm.com/index.php?rid=2767556&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19726889%26dopt%3DAbstract CONCLUSIONS: For the interpretation of FT4, its reference interval needs to be divided into 4 quartiles, which can be used as one of the predicting factors of the metabolic syndrome. PMID: 19726889 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2767556 Fri, 31 Jul 2009 23:00:00 +0100 2767556 http://www.medworm.com/index.php?rid=2767555&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19726890%26dopt%3DAbstract CONCLUSIONS: Piperacillin-tazobactam, cefoxitin, imipenem, chloramphenicol, and metronidazole are still active against B. fragilis group isolates, while clindamycin no longer has a value as an empirical therapeutic agent in Korea. Furthermore, this study identified the first imipenem-resistant B. fragilis group isolates in Korea. PMID: 19726890 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2767555 Fri, 31 Jul 2009 23:00:00 +0100 2767555 http://www.medworm.com/index.php?rid=2767554&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19726891%26dopt%3DAbstract CONCLUSIONS: VDE were not rare and seemed to emerge independently from VRE with a prolonged use of vancomycin. Vancomycin-dependence was reverted within several passages. PMID: 19726891 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2767554 Fri, 31 Jul 2009 23:00:00 +0100 2767554 http://www.medworm.com/index.php?rid=2767553&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19726892%26dopt%3DAbstract CONCLUSIONS: Seeplex(TM) Pneumobacter detection kit could be a useful screening tool for the rapid detection of respiratory bacterial pathogens. Further studies with lower respiratory tract specimens would be needed for the clinical evaluation of S. pneumoniae and H. influenzae detected by multiplex PCR. PMID: 19726892 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2767553 Fri, 31 Jul 2009 23:00:00 +0100 2767553 http://www.medworm.com/index.php?rid=2767552&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19726893%26dopt%3DAbstract CONCLUSIONS: MIRU-VNTR analysis by using well-selected loci can be useful in discriminating the clinical M. tuberculosis isolates in areas where the Beijing family is predominant. PMID: 19726893 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2767552 Fri, 31 Jul 2009 23:00:00 +0100 2767552 http://www.medworm.com/index.php?rid=2767551&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19726894%26dopt%3DAbstract CONCLUSIONS: The SD Bioline Strep A RAT kit can be useful as an alternative to throat cultures in the clinics for rapid diagnosis of GAS pharyngitis and for an early decision on the use of antibiotics. PMID: 19726894 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2767551 Fri, 31 Jul 2009 23:00:00 +0100 2767551 http://www.medworm.com/index.php?rid=2767550&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19726895%26dopt%3DAbstract CONCLUSIONS: The range between 600 nm and 700 nm was the optimal wavelength for broth microdilution antifungal susceptibility testing, although any wavelength within the visible light spectrum can be used. PMID: 19726895 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2767550 Fri, 31 Jul 2009 23:00:00 +0100 2767550 http://www.medworm.com/index.php?rid=2767549&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19726896%26dopt%3DAbstract CONCLUSIONS: The two automated RPR assay kits could not be used as an alternative to manual RPR test for quantitative analysis of RPR titer. As Mediace RPR shows a prozone effect at relatively low RPR titer, caution is needed in the interpretation of the measured values. PMID: 19726896 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2767549 Fri, 31 Jul 2009 23:00:00 +0100 2767549 http://www.medworm.com/index.php?rid=2767548&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19726897%26dopt%3DAbstract CONCLUSIONS: NIR-irradiated medium supported vascular endothelial cell proliferation and showed an anti-inflammatory effect on fibroblast culture. These results can be used as basic data for future research on the clinical application of NIR. PMID: 19726897 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2767548 Fri, 31 Jul 2009 23:00:00 +0100 2767548 http://www.medworm.com/index.php?rid=2767547&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19726898%26dopt%3DAbstract CONCLUSIONS: This meta-analysis for HIV ICA rapid tests showed good performance. In consideration of low positive predictive values of HIV rapid tests, confirmation by enzyme immunoassay or Western blot is still needed. This study would be helpful in evaluating and establishing proper performance guideline for those kits not fully evaluated. PMID: 19726898 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2767547 Fri, 31 Jul 2009 23:00:00 +0100 2767547 http://www.medworm.com/index.php?rid=2767546&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19726899%26dopt%3DAbstract CONCLUSIONS: The mononuclear cells in LRS chambers of Trima Accel(R) are an excellent alternative source of viable and functional human blood cells, which can be used for research purposes. PMID: 19726899 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2767546 Fri, 31 Jul 2009 23:00:00 +0100 2767546 http://www.medworm.com/index.php?rid=2767545&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19726900%26dopt%3DAbstract Authors: Kim KH, Kim KE, Woo KS, Han JY, Kim JM, Park KU Extremely weak D variants called DEL are serologically detectable only by adsorption-elution techniques. A nucleotide change of exon 9 in RHD gene, RHD (K409K, 1227G>A) allelic variant is present in almost all the DEL individuals of East Asians. No DEL phenotype has yet been shown to induce a primary alloanti-D immunization in East Asia. A 68-yr-old D-negative Korean man was negative for anti-D at admission, and he developed alloanti-D after transfusion of red blood cells (RBC) from 4 apparently D-negative donors. Four donors who typed D-negative by routine serologic test were analyzed by real-time PCR for RHD gene and RHD (K409K). One donor was found to have RHD (K409K). This is the first case in which DEL RBCs with RHD (K409... The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2767545 Fri, 31 Jul 2009 23:00:00 +0100 2767545 http://www.medworm.com/index.php?rid=2767544&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19726901%26dopt%3DAbstract Authors: Park IY, Shin JC, Kwon JY, Koo BK, Kim M, Lim J, Kim Y, Han K Pallister-Killian syndrome (PKS) is a rare disorder characterized cytogenetically by tetrasomy 12p for isochromosome of the short arm of chromosome 12. PKS is diagnosed by prenatal genetic analysis through chorionic villous sampling, genetic amniocentesis, and cordocentesis, or by chromosomal analysis of skin fibroblasts, but is not usually detected by chromosomal analysis of peripheral blood cells. Herein, we report a case of a gravida at 23 weeks gestation with pulmonary stenosis and right ventricular dilation of the heart which were detected by sonography. Fluorescence in situ hybridization and a multicolor banding technique were performed to verify the diagnosis as 47,XX, +mar.ish i(12)(p10)(TEL++)[16]/46,XX[4],... The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2767544 Fri, 31 Jul 2009 23:00:00 +0100 2767544 http://www.medworm.com/index.php?rid=2573534&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19571613%26dopt%3DAbstract CONCLUSIONS: We established cord blood CBC reference values of healthy Korean neonates using a large-scale CB units. The established CBC reference values from our study will be useful as basic data for CBC interpretation and assessment of transplant suitability of donated CB. PMID: 19571613 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2573534 Sun, 31 May 2009 23:00:00 +0100 2573534 http://www.medworm.com/index.php?rid=2573533&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19571614%26dopt%3DAbstract CONCLUSIONS: We found a difference in the distribution of causes of hypereosinophilia in comparison with previous Korean studies, and the most common cause of hypereosinophilia in the current study was malignancy. A rare case of clonal eosinophilia (chronic eosinophilic leukemia) associated with multiple myeloma was confirmed using molecular studies. PMID: 19571614 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2573533 Sun, 31 May 2009 23:00:00 +0100 2573533 http://www.medworm.com/index.php?rid=2573532&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19571615%26dopt%3DAbstract We report here one case of NK cell leukemia. A 54-yr-old woman presented with a 2-month history of progressive left neck mass. Based on the positive result of tissue PCR for Mycobacterium tuberculosis, she was at first diagnosed with tuberculous lymphadenopathy. After two weeks, she developed generalized lymphadenopathy, hepatosplenomegaly, fever and anemia. Subsequent evaluation was performed including bone marrow aspiration and biopsy. Peripheral blood smear showed leukoerythroblastic features with 31% blasts. Bone marrow was packed with agranular blastoid cells, which were periodic acid-Schiff (PAS) positive and myeloperoxidase (MPO) negative. Immunophenotyping showed that these cells were positive for CD45 and HLA-DR, whereas negative for CD3, CD5, CD7, CD10, CD13, CD14, CD19, CD20, CD... The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2573532 Sun, 31 May 2009 23:00:00 +0100 2573532 http://www.medworm.com/index.php?rid=2573531&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19571616%26dopt%3DAbstract Authors: Cho HS, Kim MK, Bae YK Chromosome 1 band p32 (1p32) aberrations are common in T lymphoblastic leukemia/lymphoma (T-ALL/LBL). Two types of 1p32 aberrations include translocations with different partners and submicroscopic interstitial deletion. Both aberrations are known to result in TAL1 gene deregulation. The t(1;5)(p32;q31) is a rare translocation of 1p32 in T-ALL. We now present the second case of t(1;5)(p32;q31) in T-ALL, which was present as a primary cytogenetic abnormality, with a review of the relevant literature. Interestingly, neither the translocation of the TAL1 gene nor aberrant expression of TAL1 protein was detected by fluorescent in situ hybridization (FISH) and by immunohistochemical staining in this case. PMID: 19571616 [PubMed - in process] (Source: The ... The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2573531 Sun, 31 May 2009 23:00:00 +0100 2573531 http://www.medworm.com/index.php?rid=2573530&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19571617%26dopt%3DAbstract CONCLUSIONS: Assays using DPA 300-MHA biplate were highly sensitive and specific for the detection of IMP-1 and VIM-2 type MBL-producing bacteria. In addition, it is easy to perform; so, it may be useful to apply this method for detection of IMP-1 and VIM-2 type MBL in clinical laboratories. PMID: 19571617 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2573530 Sun, 31 May 2009 23:00:00 +0100 2573530 http://www.medworm.com/index.php?rid=2573529&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19571618%26dopt%3DAbstract CONCLUSIONS: The Phoenix SMIC/ID-2 panel provided a simple and rapid susceptibility testing for S. pneumoniae, and the results were in a good agreement with those of Etest. The Phoenix system appears to be an effective automated system in clinical microbiology laboratories. PMID: 19571618 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2573529 Sun, 31 May 2009 23:00:00 +0100 2573529 http://www.medworm.com/index.php?rid=2573528&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19571619%26dopt%3DAbstract CONCLUSIONS: CTX-M-type enzymes were the most common type of ESBL in E. coli isolates from Korea, and the qnr genes were not uncommon in ESBL-producing E. coli isolates. Dissemination of E. coli containing both ESBL and qnr genes could compromise the future usefulness of the expanded-spectrum antibiotics for the treatment of infections. PMID: 19571619 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2573528 Sun, 31 May 2009 23:00:00 +0100 2573528 http://www.medworm.com/index.php?rid=2573527&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19571620%26dopt%3DAbstract CONCLUSIONS: HBV DNA-positive/HBsAg RIA-negative results were mostly observed in the patients treated with HBIG after liver transplantation, in whom HBIG escape mutations were found. Majority of these cases were positive in Architect HBsAg assay, and it is recommended to use other HBsAg immunoassay methods that are more sensitive than RIA in the detection limit as well as in the detection of escape mutant in hospitals performing liver transplantation. PMID: 19571620 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2573527 Sun, 31 May 2009 23:00:00 +0100 2573527 http://www.medworm.com/index.php?rid=2573526&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19571621%26dopt%3DAbstract CONCLUSIONS: This convenient multiplex ASPCR assay, performed using whole blood samples, provides a supplement to routine serological ABO typing and might also be useful in other genotyping applications. PMID: 19571621 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2573526 Sun, 31 May 2009 23:00:00 +0100 2573526 http://www.medworm.com/index.php?rid=2573525&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19571622%26dopt%3DAbstract This report is the first case of anti-Ku in a Knull phenotype person in Korea, who experienced a moderate hemolytic transfusion reaction. PMID: 19571622 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2573525 Sun, 31 May 2009 23:00:00 +0100 2573525 http://www.medworm.com/index.php?rid=2573524&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19571623%26dopt%3DAbstract CONCLUSIONS: JAK2 MutaScreen(TM) kit that utilizes a real-time semi-quantitative PCR method is a useful tool for diagnosing MPDs precisely. It can be used to assess the grade of mutant allele burden as well as to screen JAK2 V617F simultaneously. PMID: 19571623 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2573524 Sun, 31 May 2009 23:00:00 +0100 2573524 http://www.medworm.com/index.php?rid=2573523&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19571624%26dopt%3DAbstract CONCLUSIONS: Plasma hnRNP B1 mRNA was significantly increased in patients with lung cancer compared with that in patients with other benign lung diseases. Plasma hnRNP B1 mRNA may be useful as a potential marker for the detection of NSCLC. PMID: 19571624 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2573523 Sun, 31 May 2009 23:00:00 +0100 2573523 http://www.medworm.com/index.php?rid=2573522&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19571625%26dopt%3DAbstract We report the first case in Korea of lambda-expressing MALT lymphoma that is shown to have dual clonal rearrangements of kappa and lambda immunoglobulin light chain gene by multiplex PCR. PMID: 19571625 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2573522 Sun, 31 May 2009 23:00:00 +0100 2573522 http://www.medworm.com/index.php?rid=2573521&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19571626%26dopt%3DAbstract CONCLUSIONS: Buffer-tube minimizes false negative FOBT results during pre-analytical delay of specimen. The examinees using buffer-free containers need to be educated to hand in their specimens to laboratories as soon as possible. PMID: 19571626 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2573521 Sun, 31 May 2009 23:00:00 +0100 2573521 http://www.medworm.com/index.php?rid=2525066&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19411773%26dopt%3DAbstract Authors: Cho D, Campana D Natural killer (NK) cells can kill a wide range of cancer cells and are a promising tool for cell therapy of cancer. NK cells cytotoxicity is regulated by a balance between stimulatory and inhibitory signals. Interleukin-2 is known to increase NK cell cytotoxicity. Although many cytokines have been studied in efforts to induce durable NK cell expansions, most reports indicate a rather modest effect and the requirement for additional stimuli. We found that contact with the K562 myeloid leukemia cell line, genetically modified to express a membrane-bound form of interleukin-15 and the ligand for the costimulatory molecule 4-1BB, induced vigorous expansion of NK cells from peripheral blood. Based on these findings, we developed a method for large-scale clinical-g... The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2525066 Tue, 31 Mar 2009 23:00:00 +0100 2525066 http://www.medworm.com/index.php?rid=2525065&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19411774%26dopt%3DAbstract We report a case of a 32-yr-old female, who presented with thrombocytopenia without any neurologic involvement. Hepatosplenomegaly was detected by both physical examination and imaging studies, and a thoracic radiograph examination showed a pattern of interstitial lung disease. Biochemical tests revealed increased liver enzymes, cholesterol, triglyceride, and LDL-cholesterol, and decreased HDL-cholesterol. Sea-blue or foamy vacuolated histiocytes occurred in bone marrow and liver. Sequencing analysis of SMPD1 using genomic DNA from peripheral leukocytes identified a compound heterozygote of two mutations at exon 2: p.E246K and p.A357V. The former is a known mutation in an Italian patient, and the latter has not been reported yet. She has received oral rosuvastatin to treat hyperlipidemia a... The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2525065 Tue, 31 Mar 2009 23:00:00 +0100 2525065 http://www.medworm.com/index.php?rid=2525064&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19411775%26dopt%3DAbstract CONCLUSIONS: The decrease in PTH levels in blood samples seemed to be due to the degradation of PTH by proteases. Various proteases, including especially serine proteases, would act together to degrade PTH in blood specimen. The PTH degradation may be inhibited in blood specimen with protease inhibitor cocktail. PMID: 19411775 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2525064 Tue, 31 Mar 2009 23:00:00 +0100 2525064 http://www.medworm.com/index.php?rid=2525063&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19411776%26dopt%3DAbstract CONCLUSIONS: If the screening test for gestational DM was delayed, HbA1c level and the risk for LGA seemed to be higher, so it may be necessary to screen GDM no later than 24th week of pregnancy. PMID: 19411776 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2525063 Tue, 31 Mar 2009 23:00:00 +0100 2525063 http://www.medworm.com/index.php?rid=2525062&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19411777%26dopt%3DAbstract CONCLUSIONS: Our results suggest possible association between gammopathies and scrub typhus. Further studies in larger series will be needed for exact incidence and clinical course of gammopathies in scrub typhus. PMID: 19411777 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2525062 Tue, 31 Mar 2009 23:00:00 +0100 2525062 http://www.medworm.com/index.php?rid=2525061&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19411778%26dopt%3DAbstract CONCLUSIONS: The sensitivity of the ELISA was slightly higher than that of ELFA for toxin A and toxin B, but the specificity and positive predictive value of the ELFA were rather higher than those of the ELISA, although no statistical differences were observed. A bacteriologic culture and PCR assay for toxin genes are recommended in case the both EIAs are negative. PMID: 19411778 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2525061 Tue, 31 Mar 2009 23:00:00 +0100 2525061 http://www.medworm.com/index.php?rid=2525060&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19411779%26dopt%3DAbstract CONCLUSIONS: This study found species-specific differences in R6G accumulation in Candida. In addition, the intracellular R6G accumulation can be used to investigate the drug efflux mechanism in azole-resistant Candida strains. PMID: 19411779 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2525060 Tue, 31 Mar 2009 23:00:00 +0100 2525060 http://www.medworm.com/index.php?rid=2525059&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19411780%26dopt%3DAbstract Authors: Lee JH, Lee JH, Lee NY, Ha CW, Chung DR, Peck KR Mycoplasma hominis has been related with pelvic inflammatory illnesses and postpartum and neonatal infections. Extragenital M. hominis infections are rare, but septicemia, septic arthritis, wound infection, meningitis, and other infections in Immunocompromised patients have also been described. Here we report two cases of septic arthritis caused by M. hominis in patients following total knee replacement arthroplasty. After the surgery, the patients presented with knee pain and clinical signs of infection, such as fever, erythema and swelling on the surgical site. Arthroscopic debridement operations were performed on the surgical site. M. hominis was isolated from the joint fluid and identified by the microscopic visualization of... The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2525059 Tue, 31 Mar 2009 23:00:00 +0100 2525059 http://www.medworm.com/index.php?rid=2525058&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19411781%26dopt%3DAbstract Authors: Lee HM, Choi SH, Chung JW, Ahn J, Cho AR, Lee MK, Chang KJ With globalization, foreign patients are frequently encountered at the clinical practice in Korea. As the number of migrant workers from Southeast Asia has been notably rising since the late 1990's, unfamiliar tropical infectious diseases that they bring out, may give great challenges to the routine clinical practice in Korea. Melioidosis is a community-acquired infection caused by a gram-negative bacillus, Burkholderia pseudomallei. It has been endemic in Southeast Asia and Northern Australia, where B. pseudomallei is a soil saprophyte and invades the host through inoculation or inhalation. It frequently presents as an acute septicemia with a high mortality rate of 40%, mainly in patients with chronic underlying disea... The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2525058 Tue, 31 Mar 2009 23:00:00 +0100 2525058 http://www.medworm.com/index.php?rid=2525057&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19411782%26dopt%3DAbstract CONCLUSIONS: The DFS pattern is a frequent finding (about 28% of ANA positivity) in ANA test using indirect immunofluorescence method. Relatively high frequency of DFS pattern was observed in autoimmune diseases, contrary to the previous observations that DFS pattern is not related with autoimmune diseases. Further studies including the confirmation tests of anti-DFS70 are needed for the identification of relation between DFS pattern and particular diseases. PMID: 19411782 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2525057 Tue, 31 Mar 2009 23:00:00 +0100 2525057 http://www.medworm.com/index.php?rid=2525056&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19411783%26dopt%3DAbstract CONCLUSIONS: As there were no significant differences in the frequencies of unexpected antibodies calculated using two different criteria, both criteria can be used together for the patient population in our hospital. However, two criteria should be compared to validate the results for other populations. PMID: 19411783 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2525056 Tue, 31 Mar 2009 23:00:00 +0100 2525056 http://www.medworm.com/index.php?rid=2525055&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19411784%26dopt%3DAbstract CONCLUSIONS: By implementing a policy of platelet TD restriction, the amount of total issued PC was markedly decreased. Although post-transfusion platelet counts were decreased, the transfusion frequency in a month was not significantly increased. The restriction of platelet TD was helpful for increasing physicians' recognition of blood shortage while achieving similar transfusion effects. We conclude that 6 units of PC would be a better guideline for the platelet TD. PMID: 19411784 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2525055 Tue, 31 Mar 2009 23:00:00 +0100 2525055 http://www.medworm.com/index.php?rid=2525054&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19411785%26dopt%3DAbstract CONCLUSIONS: The KLAP has been in place successfully and stabilized over the past 8 yr. It seemed to enhance the laboratory quality. Efforts for improvement of quality control and inspector training workshops appeared to be in the main contributing factors. PMID: 19411785 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2525054 Tue, 31 Mar 2009 23:00:00 +0100 2525054 http://www.medworm.com/index.php?rid=2525052&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19411786%26dopt%3DAbstract CONCLUSIONS: Applying the six sigma, the performance level of waiting times for blood drawing exceeding five minutes were improved from 2.61 sigma to 3.35 sigma. PMID: 19411786 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2525052 Tue, 31 Mar 2009 23:00:00 +0100 2525052 http://www.medworm.com/index.php?rid=2242117&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19262072%26dopt%3DAbstract Authors: Park E, Cho M, Ki CS In biomedical research, researchers frequently use statistical procedures such as the t-test, standard analysis of variance (ANOVA), or the repeated measures ANOVA to compare means between the groups of interest. There are frequently some misuses in applying these procedures since the conditions of the experiments or statistical assumptions necessary to apply these procedures are not fully taken into consideration. In this paper, we demonstrate the correct use of repeated measures ANOVA to prevent or minimize ethical or scientific problems due to its misuse. We also describe the appropriate use of multiple comparison tests for follow-up analysis in repeated measures ANOVA. Finally, we demonstrate the use of repeated measures ANOVA by using real data and th... The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2242117 Sun, 01 Feb 2009 05:00:00 +0100 2242117 http://www.medworm.com/index.php?rid=2242116&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19262073%26dopt%3DAbstract CONCLUSIONS: This study shows that smokers had significantly lower vitamin C levels among nonenzymatic antioxidants, namely, vitamin A, C, E and coenzyme Q10. High detection rate of urine cotinine in nonsmokers show the seriousness of passive smoking exposure, therefore more social efforts should be directed to reduce passive smoking exposure. PMID: 19262073 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2242116 Sun, 01 Feb 2009 05:00:00 +0100 2242116 http://www.medworm.com/index.php?rid=2242115&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19262074%26dopt%3DAbstract CONCLUSION: CTX-M enzymes were the dominant type of ESBLs in urinary isolates of E. coli, and ESBL-producing isolates frequently contained other antimicrobial resistance genes. More than half of the urinary E. coli isolates harboring CTX-M enzymes were within the phylogenetic group B2. PMID: 19262074 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2242115 Sun, 01 Feb 2009 05:00:00 +0100 2242115 http://www.medworm.com/index.php?rid=2242114&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19262075%26dopt%3DAbstract CONCLUSIONS: DI warrants a reliable method for identification and susceptibility testing of both GPC and GNR in MicroScan, and those of only GNR in Phoenix. PMID: 19262075 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2242114 Sun, 01 Feb 2009 05:00:00 +0100 2242114 http://www.medworm.com/index.php?rid=2242113&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19262076%26dopt%3DAbstract CONCLUSIONS: Type 44 panel showed an excellent performance in detecting ESBL-producing E. coli, Klebsiella spp., and P. mirabilis. When flagged as "Confirmed ESBL", no other confirmatory test was necessary to report as ESBL; however, "Possible ESBL" required a differential test for AmpC production. PMID: 19262076 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2242113 Sun, 01 Feb 2009 05:00:00 +0100 2242113 http://www.medworm.com/index.php?rid=2242112&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19262077%26dopt%3DAbstract We report a catheter-related bacteremia of T. pulmonis. A 39 yr-old male with ALL was hospitalized to receive bone marrow transplantation (BMT). Although the patient developed a high fever at the 7th hospital day (HD), it subsided with vancomycin treatment, and he received BMT at 9th HD. Fever resurged at 16th HD despite sustained treatment with vancomycin, meropenem, and amphotericin B, but subsided with removal of Hickman catheter (HC) at 19th HD. Three sets of blood cultures comprising one from the HC and two from venipunctures were taken at 7th, 16th, and 19th HD, and the distal tip of the HC was also cultured. The aerobic vials of all 3 HC-withdrawn blood cultures and one peripheral blood culture taken at 19HD and the HC tip culture grew long, straight, thin gram-positive rods that we... The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2242112 Sun, 01 Feb 2009 05:00:00 +0100 2242112 http://www.medworm.com/index.php?rid=2242111&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19262078%26dopt%3DAbstract CONCLUSIONS: SD Bioline Chagas Ab Rapid kit showed test results highly correlating with those of National Reference Laboratory for Chagas and Leishmaniasis. It can be used for a rapid detection of Chagas' disease in endemic region and monitoring the disease among overseas travelers in Korea. PMID: 19262078 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2242111 Sun, 01 Feb 2009 05:00:00 +0100 2242111 http://www.medworm.com/index.php?rid=2242110&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19262079%26dopt%3DAbstract CONCLUSIONS: It was found that HBV detected in Korean CHB patients under treatment almost all belong to the C2 (Ce) genotype. PMID: 19262079 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2242110 Sun, 01 Feb 2009 05:00:00 +0100 2242110 http://www.medworm.com/index.php?rid=2242109&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19262080%26dopt%3DAbstract CONCLUSIONS: Although additional donor screening tests for anti-HBc and anti-HBs requires increased cost and relatively small number of donors are additionally excluded by these tests, they are considered to be helpful for the safety of blood products, because our blood center has characteristics with small number of donors and relatively high percentage of donors in the age group of thirties and older. PMID: 19262080 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2242109 Sun, 01 Feb 2009 05:00:00 +0100 2242109 http://www.medworm.com/index.php?rid=2242108&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19262081%26dopt%3DAbstract In conclusion, the patient was diagnosed to have de novo 46,XX,der(2)t(2;15)(q37.3;q25.3) chromosome complement. Adequate genetic counseling and regular follow-ups would be needed for the patient. PMID: 19262081 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2242108 Sun, 01 Feb 2009 05:00:00 +0100 2242108 http://www.medworm.com/index.php?rid=2242107&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19262082%26dopt%3DAbstract CONCLUSIONS: On the basis of these results, we conclude that MLPA is an accurate, reliable, and cost-effective alternative to FISH in the screening for microdeletion syndromes. PMID: 19262082 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2242107 Sun, 01 Feb 2009 05:00:00 +0100 2242107 http://www.medworm.com/index.php?rid=2242106&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19262083%26dopt%3DAbstract Authors: Kim JH, Oh PS, Na HY, Kim SH, Cho HC Ring chromosome is a structural abnormality that is thought to be the result of fusion and breakage in the short and long arms of chromosome. Wolf-Hirschhorn syndrome (WHS) is a well-known congenital anomaly in the ring chromosome 4 with a partial deletion of the distal short arm. Here we report a 10-month-old male of mosaic ring chromosome 4 with the chief complaint of severe short stature. He showed the height of -4 standard deviation, subtle hypothyroidism and mild atrial septal defect/ventricular septal defect, and also a mild language developmental delay was suspected. Brain magnetic resonance imaging showed multifocal leukomalacia. Chromosomal analysis of the peripheral blood showed the mosaic karyotype with [46,XY,r(4)(p16q35)[84]/45... The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2242106 Sun, 01 Feb 2009 05:00:00 +0100 2242106 http://www.medworm.com/index.php?rid=2242105&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19262084%26dopt%3DAbstract CONCLUSIONS: Serum TPO was elevated with thrombocytopenia and related to impaired hematopoiesis. The elevated TPO without thrombocytopenia might be considered as impaired hematopoiesis and a marker for disease progression in patients with MM. PMID: 19262084 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2242105 Sun, 01 Feb 2009 05:00:00 +0100 2242105 http://www.medworm.com/index.php?rid=2201883&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19127104%26dopt%3DAbstract CONCLUSIONS: Statistical correlation between the presence of trisomy 1q and prognostic markers suggests that the evaluation of trisomy 1q in multiple myeloma patients may be used for the indirect assessment of prognosis in these patients. PMID: 19127104 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2201883 Mon, 01 Dec 2008 05:00:00 +0100 2201883 http://www.medworm.com/index.php?rid=2201882&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19127105%26dopt%3DAbstract CONCLUSIONS: D-dimer test cannot be used as a stand-alone test to diagnose PE, but it can be helpful for exclusion of PE especially in 'PE unlikely' group according to Wells score. PMID: 19127105 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2201882 Mon, 01 Dec 2008 05:00:00 +0100 2201882 http://www.medworm.com/index.php?rid=2201881&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19127106%26dopt%3DAbstract Authors: Im M, Lee JK, Hong YJ, Hong SI, Kang HJ, Na II, Ryoo BY, Cheon GJ, Lee HN, Chang YH Ionizing radiation including I(131) might produce chromosomal translocation, causing hematologic malignancy. The incidence of leukemia following radioactive iodine treatment for thyroid cancer has been reported to be approximately 0.1 to 2.0% in Western countries, whereas fewer cases have been reported in Korea. We hereby report four cases of secondary hematologic malignancy, who received iodine therapy for thyroid cancer after thyroidectomy: two cases of acute lymphoblastic leukemia with t(9;22)(q34;q11.2), a case of MDS with 5q deletion, and a case of MDS with normal karyotype. Three cases of hematologic malignancy have developed after cumulative dosage of less than 800 mCi. The treatment int... The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2201881 Mon, 01 Dec 2008 05:00:00 +0100 2201881 http://www.medworm.com/index.php?rid=2201880&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19127108%26dopt%3DAbstract CONCLUSIONS: Measurement of salivary amylase using Salivette could be a useful test having good intra-run CVs and linearity. More than 1.5 mL of saliva would be needed to have more than 70% recovery of Salivette. PMID: 19127108 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2201880 Mon, 01 Dec 2008 05:00:00 +0100 2201880 http://www.medworm.com/index.php?rid=2201879&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19127109%26dopt%3DAbstract Authors: Hong KH, Park JS, Kim EC Since its first isolation in 1997, vancomycin-intermediate Staphylococcus aureus (VISA) has been a clinical concern because it may lead to treatment failure. Up to the present, there were two reports of clinical VISA cases in Korea. We now report two additional cases of VISA with the minimum inhibitory concentration (MIC) of 4 microg/mL. The first patient was a 59 yr-old man who had undergone total hip replacement arthroplasty in 1999 due to avascular necrosis of femur heads. He had recurrent episodes of infected hip caused by methicillin-resistant Staphylococcus aureus (MRSA) and was treated with vancomycin. He underwent replacement operation of prosthesis. Cultures of joint fluid and joint tissue grew S. aureus. Vancomycin MIC as determined by a brot... The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2201879 Mon, 01 Dec 2008 05:00:00 +0100 2201879 http://www.medworm.com/index.php?rid=2201878&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19127110%26dopt%3DAbstract CONCLUSIONS: Highly immunoreactive anti-TSST-1 monoclonal antibody was produced by the use of synthesized peptide antigen. Diagnostic and protective capacity of this monoclonal antibody should be evaluated in the future. PMID: 19127110 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2201878 Mon, 01 Dec 2008 05:00:00 +0100 2201878 http://www.medworm.com/index.php?rid=2201877&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19127111%26dopt%3DAbstract CONCLUSIONS: Diagnostic performance of automated AxSYM anti-CCP assay was comparable to that of DIASTAT 96 well plate ELISA method. AxSYM anti-CCP assay has an advantage of random access capability and will be useful in laboratories with low sample number and/or with a need of rapid turnaround time. PMID: 19127111 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2201877 Mon, 01 Dec 2008 05:00:00 +0100 2201877 http://www.medworm.com/index.php?rid=2201876&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19127112%26dopt%3DAbstract CONCLUSIONS: We provided the allele and haplotype frequencies of HLA-A, -B, and -DR in cord blood units of Korean ethnicity defined by a DNA typing method, which can be used as basic data on Koreans for organ transplantation and disease association studies. PMID: 19127112 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2201876 Mon, 01 Dec 2008 05:00:00 +0100 2201876 http://www.medworm.com/index.php?rid=2201875&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19127113%26dopt%3DAbstract CONCLUSIONS: Based on the results and literature review, we established a new syphilis test algorithm using AST as a screening test, which would be helpful for detection of more syphilis patients including latent infections. PMID: 19127113 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2201875 Mon, 01 Dec 2008 05:00:00 +0100 2201875 http://www.medworm.com/index.php?rid=2090513&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19127103%26dopt%3DAbstract Authors: Harada S, Ishii Y, Yamaguchi K Production of extended-spectrum beta-lactamase (ESBL) is one of the most important resistance mechanisms that hamper the antimicrobial treatment of infections caused by Enterobacteriaceae. ESBLs are classified into several groups according to their amino-acid sequence homology. While TEM and SHV enzymes were the most common ESBLs in the 1990s, CTX-M enzymes have spread rapidly among Enterobacteriaceae in the past decade. In addition, some epidemiological studies showed that organisms producing CTX-M enzymes had become increasingly prevalent in the community setting in certain areas in the world. Several novel enzymes with hydrolyzing activity against oxyimino-cephalosporins, albeit with additional enzymatic characteristics different from those of... The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2090513 Mon, 01 Dec 2008 05:00:00 +0100 2090513 http://www.medworm.com/index.php?rid=2090512&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19127104%26dopt%3DAbstract CONCLUSIONS: Statistical correlation between the presence of trisomy 1q and prognostic markers suggests that the evaluation of trisomy 1q in multiple myeloma patients may be used for the indirect assessment of prognosis in these patients. PMID: 19127104 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2090512 Mon, 01 Dec 2008 05:00:00 +0100 2090512 http://www.medworm.com/index.php?rid=2090511&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19127105%26dopt%3DAbstract CONCLUSIONS: D-dimer test cannot be used as a stand-alone test to diagnose PE, but it can be helpful for exclusion of PE especially in 'PE unlikely' group according to Wells score. PMID: 19127105 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2090511 Mon, 01 Dec 2008 05:00:00 +0100 2090511 http://www.medworm.com/index.php?rid=2090510&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19127106%26dopt%3DAbstract Authors: Im M, Lee JK, Hong YJ, Hong SI, Kang HJ, Na II, Ryoo BY, Cheon GJ, Lee HN, Chang YH Ionizing radiation including I(131) might produce chromosomal translocation, causing hematologic malignancy. The incidence of leukemia following radioactive iodine treatment for thyroid cancer has been reported to be approximately 0.1 to 2.0% in Western countries, whereas fewer cases have been reported in Korea. We hereby report four cases of secondary hematologic malignancy, who received iodine therapy for thyroid cancer after thyroidectomy: two cases of acute lymphoblastic leukemia with t(9;22)(q34;q11.2), a case of MDS with 5q deletion, and a case of MDS with normal karyotype. Three cases of hematologic malignancy have developed after cumulative dosage of less than 800 mCi. The treatment int... The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2090510 Mon, 01 Dec 2008 05:00:00 +0100 2090510 http://www.medworm.com/index.php?rid=2090509&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19127107%26dopt%3DAbstract CONCLUSIONS: These data suggest that hTERT might be a target molecule for drug-resistant tumor therapy. PMID: 19127107 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2090509 Mon, 01 Dec 2008 05:00:00 +0100 2090509 http://www.medworm.com/index.php?rid=2090508&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19127108%26dopt%3DAbstract CONCLUSIONS: Measurement of salivary amylase using Salivette could be a useful test having good intra-run CVs and linearity. More than 1.5 mL of saliva would be needed to have more than 70% recovery of Salivette. PMID: 19127108 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2090508 Mon, 01 Dec 2008 05:00:00 +0100 2090508 http://www.medworm.com/index.php?rid=2090507&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19127109%26dopt%3DAbstract Authors: Hong KH, Park JS, Kim EC Since its first isolation in 1997, vancomycin-intermediate Staphylococcus aureus (VISA) has been a clinical concern because it may lead to treatment failure. Up to the present, there were two reports of clinical VISA cases in Korea. We now report two additional cases of VISA with the minimum inhibitory concentration (MIC) of 4 microg/mL. The first patient was a 59 yr-old man who had undergone total hip replacement arthroplasty in 1999 due to avascular necrosis of femur heads. He had recurrent episodes of infected hip caused by methicillin-resistant Staphylococcus aureus (MRSA) and was treated with vancomycin. He underwent replacement operation of prosthesis. Cultures of joint fluid and joint tissue grew S. aureus. Vancomycin MIC as determined by a brot... The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2090507 Mon, 01 Dec 2008 05:00:00 +0100 2090507 http://www.medworm.com/index.php?rid=2090506&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19127110%26dopt%3DAbstract CONCLUSIONS: Highly immunoreactive anti-TSST-1 monoclonal antibody was produced by the use of synthesized peptide antigen. Diagnostic and protective capacity of this monoclonal antibody should be evaluated in the future. PMID: 19127110 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2090506 Mon, 01 Dec 2008 05:00:00 +0100 2090506 http://www.medworm.com/index.php?rid=2090505&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19127111%26dopt%3DAbstract CONCLUSIONS: Diagnostic performance of automated AxSYM anti-CCP assay was comparable to that of DIASTAT 96 well plate ELISA method. AxSYM anti-CCP assay has an advantage of random access capability and will be useful in laboratories with low sample number and/or with a need of rapid turnaround time. PMID: 19127111 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2090505 Mon, 01 Dec 2008 05:00:00 +0100 2090505 http://www.medworm.com/index.php?rid=2090504&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19127112%26dopt%3DAbstract CONCLUSIONS: We provided the allele and haplotype frequencies of HLA-A, -B, and -DR in cord blood units of Korean ethnicity defined by a DNA typing method, which can be used as basic data on Koreans for organ transplantation and disease association studies. PMID: 19127112 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2090504 Mon, 01 Dec 2008 05:00:00 +0100 2090504 http://www.medworm.com/index.php?rid=2090503&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19127113%26dopt%3DAbstract CONCLUSIONS: Based on the results and literature review, we established a new syphilis test algorithm using AST as a screening test, which would be helpful for detection of more syphilis patients including latent infections. PMID: 19127113 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2090503 Mon, 01 Dec 2008 05:00:00 +0100 2090503 http://www.medworm.com/index.php?rid=2090502&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19127114%26dopt%3DAbstract CONCLUSIONS: Molecular genetic tests are not only essential for diagnosis, but also helpful for suggesting the spectrum and relationship between genotype and phenotype in Korean DM1 patients. PMID: 19127114 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2090502 Mon, 01 Dec 2008 05:00:00 +0100 2090502 http://www.medworm.com/index.php?rid=2090501&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19127115%26dopt%3DAbstract We report a 26-yr-old female patient with bilateral breast cancer who was clinically diagnosed with Li-Fraumeni like syndrome (LFL) and subsequently found to have a germline mutation of the TP53 gene. The patient was initially diagnosed with right breast cancer at age 24 yr and then with left breast cancer at age 25 yr. Surgery and radiotherapy were performed accordingly. The patient had a family history of various types of early onset cancers and was referred to a genetic counseling clinic. She was clinically diagnosed with LFL. Genetic analysis of the TP53 tumor suppressor gene was performed with the patient's consent. Direct sequencing of TP53 gene exons 5, 6, 8, 9, and 11 revealed a ermline missense mutation, resulting in an amino acid change from an arginine to a histidine (g.13203G&g... The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2090501 Mon, 01 Dec 2008 05:00:00 +0100 2090501 http://www.medworm.com/index.php?rid=2054058&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18971612%26dopt%3DAbstract CONCLUSIONS: Oxidative stress reduces the deformability of erythrocytes and the deformability could be one of markers for oxidative damage. Verapamil and ascorbic acid have protective role against tBHP induced oxidative stress. The ektacytometer, RheoScan-D used in this study is convenient for clinical measurement and could be used in various fields of clinical medicine. PMID: 18971612 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2054058 Wed, 01 Oct 2008 04:00:00 +0100 2054058 http://www.medworm.com/index.php?rid=2054057&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18971613%26dopt%3DAbstract CONCLUSIONS: The malaria non-specific panel test composed of hematology autoanalyzer-derived parameters showed relatively good, but slightly lower sensitivity than that of malaria-specific antibody test. It might be used as a screening test for the diagnosis of malaria infection, and addition of HDL cholesterol improved little the usefulness of the panel test. PMID: 18971613 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2054057 Wed, 01 Oct 2008 04:00:00 +0100 2054057 http://www.medworm.com/index.php?rid=2054056&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18971614%26dopt%3DAbstract CONCLUSIONS: Minor elevation of cTnI value, even in group 3 was significantly associated with high incidence of AMI, IHD, CVD, and death rate after 1 month. PMID: 18971614 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2054056 Wed, 01 Oct 2008 04:00:00 +0100 2054056 http://www.medworm.com/index.php?rid=2054055&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18971615%26dopt%3DAbstract CONCLUSIONS: Our study showed that Etest may be more useful to discriminate yeast isolates with reduced susceptibility to AMB, and some isolates of less common yeast species from Korea may have decreased AMB susceptibilities. PMID: 18971615 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2054055 Wed, 01 Oct 2008 04:00:00 +0100 2054055 http://www.medworm.com/index.php?rid=2054054&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18971616%26dopt%3DAbstract CONCLUSIONS: LIA detecting several autoantibodies simultaneously might replace ELISA for anti-ENA antibodies, but not for anti-dsDNA antibodies. When LIA is performed considering clinical manifestations and FANA, it could contribute to the diagnosis of systemic autoimmune disease. PMID: 18971616 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2054054 Wed, 01 Oct 2008 04:00:00 +0100 2054054 http://www.medworm.com/index.php?rid=2054053&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18971617%26dopt%3DAbstract CONCLUSIONS: Application of CREG enhanced the rate of antibody identification. Antibody specificities of those cases where CREG specificities were different between Rodey and Takemoto classifications were almost the same when compared at the individual antigen level. Therefore, it was thought that it makes no difference to use any one of these two classifications in interpreting PRA. PMID: 18971617 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2054053 Wed, 01 Oct 2008 04:00:00 +0100 2054053 http://www.medworm.com/index.php?rid=2054052&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18971618%26dopt%3DAbstract CONCLUSIONS: Co-circulation of two distinct HAV genotypes (IA and IIIA) was observed from the northeastern Seoul for the year studied. PMID: 18971618 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2054052 Wed, 01 Oct 2008 04:00:00 +0100 2054052 http://www.medworm.com/index.php?rid=2054051&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18971620%26dopt%3DAbstract CONCLUSIONS: DPO PCR shows a high agreement of results with the conventional PCR and is considered an adequate method to be used as a primary genetic test for the diagnosis of DMD. Because of an improved accuracy, especially for determining the boundaries of DMD gene deletions, DPO PCR can be very useful as a supplement to the conventional PCR. PMID: 18971620 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2054051 Wed, 01 Oct 2008 04:00:00 +0100 2054051 http://www.medworm.com/index.php?rid=2054050&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18971621%26dopt%3DAbstract CONCLUSIONS: An excellent correlation was found between FISH on FNA cells and corresponding FFPE sections. We recommend FNA specimens for more rapid determination of HER2 status by FISH, which will be helpful for patient selection for individualized therapy. PMID: 18971621 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=2054050 Wed, 01 Oct 2008 04:00:00 +0100 2054050 http://www.medworm.com/index.php?rid=1921719&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18971612%26dopt%3DAbstract CONCLUSIONS: Oxidative stress reduces the deformability of erythrocytes and the deformability could be one of markers for oxidative damage. Verapamil and ascorbic acid have protective role against tBHP induced oxidative stress. The ektacytometer, RheoScan-D used in this study is convenient for clinical measurement and could be used in various fields of clinical medicine. PMID: 18971612 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=1921719 Wed, 01 Oct 2008 04:00:00 +0100 1921719 http://www.medworm.com/index.php?rid=1921718&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18971613%26dopt%3DAbstract CONCLUSIONS: The malaria non-specific panel test composed of hematology autoanalyzer-derived parameters showed relatively good, but slightly lower sensitivity than that of malaria-specific antibody test. It might be used as a screening test for the diagnosis of malaria infection, and addition of HDL cholesterol improved little the usefulness of the panel test. PMID: 18971613 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=1921718 Wed, 01 Oct 2008 04:00:00 +0100 1921718 http://www.medworm.com/index.php?rid=1921717&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18971614%26dopt%3DAbstract CONCLUSIONS: Minor elevation of cTnI value, even in group 3 was significantly associated with high incidence of AMI, IHD, CVD, and death rate after 1 month. PMID: 18971614 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=1921717 Wed, 01 Oct 2008 04:00:00 +0100 1921717 http://www.medworm.com/index.php?rid=1921716&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18971615%26dopt%3DAbstract CONCLUSIONS: Our study showed that Etest may be more useful to discriminate yeast isolates with reduced susceptibility to AMB, and some isolates of less common yeast species from Korea may have decreased AMB susceptibilities. PMID: 18971615 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=1921716 Wed, 01 Oct 2008 04:00:00 +0100 1921716 http://www.medworm.com/index.php?rid=1921715&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18971616%26dopt%3DAbstract CONCLUSIONS: LIA detecting several autoantibodies simultaneously might replace ELISA for anti-ENA antibodies, but not for anti-dsDNA antibodies. When LIA is performed considering clinical manifestations and FANA, it could contribute to the diagnosis of systemic autoimmune disease. PMID: 18971616 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=1921715 Wed, 01 Oct 2008 04:00:00 +0100 1921715 http://www.medworm.com/index.php?rid=1921714&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18971617%26dopt%3DAbstract CONCLUSIONS: Application of CREG enhanced the rate of antibody identification. Antibody specificities of those cases where CREG specificities were different between Rodey and Takemoto classifications were almost the same when compared at the individual antigen level. Therefore, it was thought that it makes no difference to use any one of these two classifications in interpreting PRA. PMID: 18971617 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=1921714 Wed, 01 Oct 2008 04:00:00 +0100 1921714 http://www.medworm.com/index.php?rid=1921713&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18971618%26dopt%3DAbstract CONCLUSIONS: Co-circulation of two distinct HAV genotypes (IA and IIIA) was observed from the northeastern Seoul for the year studied. PMID: 18971618 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=1921713 Wed, 01 Oct 2008 04:00:00 +0100 1921713 http://www.medworm.com/index.php?rid=1921712&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18971619%26dopt%3DAbstract CONCLUSIONS: The present study could be used for the establishment of a database for genetic counseling. The discovery of an abnormality provides the option of termination or continuation in the pregnancy, a more suitable obstetric management in Korea. PMID: 18971619 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=1921712 Wed, 01 Oct 2008 04:00:00 +0100 1921712 http://www.medworm.com/index.php?rid=1921711&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18971620%26dopt%3DAbstract CONCLUSIONS: DPO PCR shows a high agreement of results with the conventional PCR and is considered an adequate method to be used as a primary genetic test for the diagnosis of DMD. Because of an improved accuracy, especially for determining the boundaries of DMD gene deletions, DPO PCR can be very useful as a supplement to the conventional PCR. PMID: 18971620 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=1921711 Wed, 01 Oct 2008 04:00:00 +0100 1921711 http://www.medworm.com/index.php?rid=1921710&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18971621%26dopt%3DAbstract CONCLUSIONS: An excellent correlation was found between FISH on FNA cells and corresponding FFPE sections. We recommend FNA specimens for more rapid determination of HER2 status by FISH, which will be helpful for patient selection for individualized therapy. PMID: 18971621 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=1921710 Wed, 01 Oct 2008 04:00:00 +0100 1921710 http://www.medworm.com/index.php?rid=1880780&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18728372%26dopt%3DAbstract CONCLUSIONS: We demonstrated the distribution of platelet reactivity before and after aspirin treatment using the VerifyNow Aspirin Assay. The incidence of aspirin resistance was 10.1%, and low Hb level and high platelet count were related with aspirin resistance. PMID: 18728372 [PubMed - in process] (Source: The Korean Journal of Laboratory Medicine) The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=1880780 Fri, 01 Aug 2008 04:00:00 +0100 1880780 http://www.medworm.com/index.php?rid=1880779&cid=s_36967_166_f&fid=36967&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18728373%26dopt%3DAbstract Authors: Lee SY, Nam EM, Lee SN, Kim HJ, Hong KS Type 2N von Willebrand disease (vWD) can be confused with hemophilia A due to decreased factor VIII levels and a bleeding tendency, and differential diagnosis is of importance for providing the optimal treatment and genetic counseling. For the accurate diagnosis of type 2N vWD, von Willebrand Factor (vWF) function tests, multimer assay and gene mutation analysis are needed. The patient was a 38-yr-old Nepalese woman with a history of bleeding manifestations from childhood, such as hemarthrosis, intramuscular hematoma, and menorrhagia. Family history revealed that her mother and elder brothers also had bleeding manifestations from childhood. When she had a laparotomy in 1991, she was diagnosed as hemophilia A with factor VIII level of 3.6... The Korean Journal of Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=1880779 Fri, 01 Aug 2008 04:00:00 +0100 1880779