MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'The Netherlands Journal of Medicine' source. Wed, 08 Feb 2012 18:50:45 +0100 http://www.medworm.com/index.php?rid=5627532&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22271807%26dopt%3DAbstract Authors: Klempner MS, Halperin JJ, Baker PJ, Shapiro ED, O'Connell S, Fingerle V, Wormser GP Abstract No abstract available. PMID: 22271807 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5627532 Sun, 01 Jan 2012 05:00:00 +0100 5627532 http://www.medworm.com/index.php?rid=5627531&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22271808%26dopt%3DAbstract Authors: Broekhuizen BD, Sachs AP, Hoes AW, Verheij TJ, Moons KG Abstract Detection of early chronic obstructive pulmonary disease (COPD) in patients presenting with respiratory symptoms is recommended; however, diagnosing COPD is difficult because a single gold standard is not available. The aim of this article is to review and interpret the existing evidence, theories and consensus on the individual parts of the diagnostic work-up for COPD. Relevant articles are discussed under the subheadings: history taking, physical examination, spirometry and additional lung function assessment. Wheezing, cough, phlegm and breathlessness on exertion are suggestive signs for COPD. The diagnostic value of the physical examination is limited, except for auscultated pulmonary wheezing or... The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5627531 Sun, 01 Jan 2012 05:00:00 +0100 5627531 http://www.medworm.com/index.php?rid=5627530&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22271809%26dopt%3DAbstract Authors: Radic M, Martinovic Kaliterna1 D, Radic J Abstract Drug-induced vasculitis is an inflammation of blood vessels caused by the use of various pharmaceutical agents. Vasculitis causes changes in the walls of blood vessels, including thickening, weakening, narrowing and scarring. Inflammation can be short-term (acute) or long-term (chronic) and can be so severe that the tissues and organs supplied by the affected vessels do not get enough blood. The shortage of blood can result in organ and tissue damage, even death. Drug-induced vasculitis is the most common form of vasculitis. The differential diagnosis between drug-induced and idiopathic vasculitic conditions may be difficult in the individual patient. Withdrawal may be helpful to distinguish between these syndromes. Withdr... The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5627530 Sun, 01 Jan 2012 05:00:00 +0100 5627530 http://www.medworm.com/index.php?rid=5627529&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22271810%26dopt%3DAbstract Authors: Beijers AJ, Jongen JL, Vreugdenhil G Abstract Chemotherapy-induced peripheral neuropathy (CIPN) is a common major dose-limiting side effect of many chemotherapeutic agents, including platinum compounds, taxanes, vinca alkaloids, thalidomide and newer agents such as bortezomib. The incidence and degree of neuropathy depends on the type of cytotoxic drug, the duration of administration, cumulative dose and pre-existing peripheral neuropathy. Because of increasing survival rates of patients treated with neurotoxic agents, CIPN is accompanied by a significant decrease in the patient's quality of life among cancer survivors. Therefore, several neuroprotective strategies, including calcium÷magnesium infusion, amifostine, gluthatione, glutamine, acetyl-L-carnitine and erythropoi... The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5627529 Sun, 01 Jan 2012 05:00:00 +0100 5627529 http://www.medworm.com/index.php?rid=5627528&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22271811%26dopt%3DAbstract Authors: Bipat S, Niekel MC, Comans EF, Nio CY, Bemelman WA, Verhoef C, Stoker J Abstract Dutch guidelines made the following recommendations for staging colorectal cancer (CRC). For liver metastases, computed tomography (CT) or magnetic resonance imaging (MRI) could be used. For lung metastases, imaging could be limited to chest X-ray. The primary aim of this survey was to summarise the use of imaging modalities and the variation in techniques. Three surveys were created and sent to three groups of medical specialists, namely surgeons, radiologists and nuclear medicine physicians. The management survey included questions on the role of different modalities for evaluation of synchronous liver, lung and extrahepatic metastases. The radiological survey included questions concerning t... The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5627528 Sun, 01 Jan 2012 05:00:00 +0100 5627528 http://www.medworm.com/index.php?rid=5627527&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22271812%26dopt%3DAbstract Conclusion: In clinical practice, different treatment scenarios are chosen for the treatment of elderly patients with symptomatic hypercalcaemia caused by PHPT. The introduction of cinacalcet offers a new treatment paradigm. We propose to apply cinacalcet preceding elective surgery as an alternative option to standard therapy or as maintenance dose when surgery is not possible. PMID: 22271812 [PubMed - in process] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5627527 Sun, 01 Jan 2012 05:00:00 +0100 5627527 http://www.medworm.com/index.php?rid=5627526&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22271813%26dopt%3DAbstract Authors: de Blauw MH Abstract No abstract available. PMID: 22271813 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5627526 Sun, 01 Jan 2012 05:00:00 +0100 5627526 http://www.medworm.com/index.php?rid=5627525&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22271814%26dopt%3DAbstract Authors: Wendker-van Wattum M, Wouters RS, van der Wal JE, Glaudemans AW, Wolffenbuttel BH Abstract No abstract available. PMID: 22271814 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5627525 Sun, 01 Jan 2012 05:00:00 +0100 5627525 http://www.medworm.com/index.php?rid=5627524&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22271815%26dopt%3DAbstract Authors: Tsai CH, Yang1 FJ, Huang CC, Kuo CC, Chen YM Abstract No abstract available. PMID: 22271815 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5627524 Sun, 01 Jan 2012 05:00:00 +0100 5627524 http://www.medworm.com/index.php?rid=5627523&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22271816%26dopt%3DAbstract Authors: Veldhuis S, Kalpoe JS, Bruin S, Lauw FN Abstract No abstract available. PMID: 22271816 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5627523 Sun, 01 Jan 2012 05:00:00 +0100 5627523 http://www.medworm.com/index.php?rid=5627522&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22271817%26dopt%3DAbstract Authors: Kuiper LM, Thijs A, Smulders YM Abstract Background: The advent of beamer projection of radiological images raises the issue of whether such projection compromises diagnostic accuracy. The purpose of this study was to evaluate whether beamer projection of chest X-rays is inferior to monitor display. Methods: We selected 53 chest X-rays with subtle abnormalities and 15 normal X-rays. The images were independently judged by a senior radiologist and a senior pulmonologist with a state-of-art computer monitor. We used their unanimous or consensus judgment as the reference test. Subsequently, four observers (one senior pulmonologist, one senior radiologist and one resident from each speciality) judged these X-rays on a standard clinical computer monitor and with beamer projecti... The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5627522 Sun, 01 Jan 2012 05:00:00 +0100 5627522 http://www.medworm.com/index.php?rid=5627521&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22271818%26dopt%3DAbstract Authors: Smulders YM, Peters MJ, Serne EH Abstract No abstract available. PMID: 22271818 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5627521 Sun, 01 Jan 2012 05:00:00 +0100 5627521 http://www.medworm.com/index.php?rid=5627520&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22271819%26dopt%3DAbstract Authors: Beutler JJ, van den Born BJ, Gaillard CA, de Gooijer A, Kroon AA, van den Meiracker AH Abstract No abstract available. PMID: 22271819 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5627520 Sun, 01 Jan 2012 05:00:00 +0100 5627520 http://www.medworm.com/index.php?rid=5517110&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22173360%26dopt%3DAbstract Authors: Levi MM Abstract No abstract available. PMID: 22173360 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5517110 Thu, 01 Dec 2011 05:00:00 +0100 5517110 http://www.medworm.com/index.php?rid=5517109&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22173361%26dopt%3DAbstract Authors: Schipperus M, Fijnheer R Abstract Understanding of the mechanisms and aetiology of immune thrombocytopenia (ITP) has progressed significantly in recent years. It is now recognised to be an autoimmune condition, involving not only platelet destruction, but also deficits in platelet production. This has led to widespread research exploring potential mechanisms for therapy, the result of which has been the development of romiplostim and eltrombopag. These new treatments target the thrombopoietin receptor (TPO-R), promoting formation of megakaryocytes and survival of platelets. Furthermore, the advances in the understanding of ITP have led to the production of guidelines to assist healthcare professionals in the diagnosis and treatment of ITP. This review examines the recommen... The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5517109 Thu, 01 Dec 2011 05:00:00 +0100 5517109 http://www.medworm.com/index.php?rid=5517108&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22173362%26dopt%3DAbstract Authors: Diamant Z, Tarasevych S, Clarke GW Abstract Asthma and COPD are chronic inflammatory airway disorders with systemic manifestations. The two diseases have different airway inflammation, features of airway remodelling with subsequent pathophysiology and clinical presentation. The international management guidelines recommend stepwise pharmacotherapy depending on disease control and÷or disease stage, comprising relievers and overall uniform controller treatment, despite the heterogeneity across the conditions and treatment response. Despite effective medications per se, still too many patients remain uncontrolled and no treatment can definitely cure either of the conditions. This overview includes currently recommended pharmacotherapeutic options with novel and future treatm... The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5517108 Thu, 01 Dec 2011 05:00:00 +0100 5517108 http://www.medworm.com/index.php?rid=5517107&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22173363%26dopt%3DAbstract Authors: Habib SM, Betjes MG, Fieren MW, Boeschoten EW, Abrahams AC, Boer WH, Struijk DG, Ruger W, Krikke C, Westerhuis R, de Sévaux RG, van der Sande FM, Gaasbeek A, Korte-On Behalf Of The Eps Registry MR Abstract Encapsulating peritoneal sclerosis (EPS) represents a rare complication of long-term peritoneal dialysis (PD). It is characterised by diffuse peritoneal membrane fibrosis, progressive intestinal encapsulation and the clinical spectrum of intestinal obstruction. The pathogenesis is as yet not well understood but includes inflammation, angiogenesis and fibrosis. The current diagnosis of EPS lacks specificity and relies on clinical, radiographic or macroscopic evaluation. There is no general agreement on managing EPS although accumulating clinical data suggest drug treatme... The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5517107 Thu, 01 Dec 2011 05:00:00 +0100 5517107 http://www.medworm.com/index.php?rid=5517106&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22173364%26dopt%3DAbstract We report a fatal outcome of B. cereus septicaemia in an immunocompetent patient with a mechanical mitral valve. PMID: 22173364 [PubMed - in process] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5517106 Thu, 01 Dec 2011 05:00:00 +0100 5517106 http://www.medworm.com/index.php?rid=5517105&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22173365%26dopt%3DAbstract Conclusion: In both groups, risk factor management improved. However, changes in BP control, lipid management and medication use were more pronounced in IG than in CG. Lifestyle interventions were not effective. Coaching by NPs thus benefits everyday care of CKD patients. Whether these changes translate into improvement in clinical endpoints remains to be established. PMID: 22173365 [PubMed - in process] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5517105 Thu, 01 Dec 2011 05:00:00 +0100 5517105 http://www.medworm.com/index.php?rid=5517104&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22173366%26dopt%3DAbstract Authors: Zhu M, Tang A, Amatya N, Qiu L Abstract No abstract available. PMID: 22173366 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5517104 Thu, 01 Dec 2011 05:00:00 +0100 5517104 http://www.medworm.com/index.php?rid=5517103&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22173367%26dopt%3DAbstract Authors: Opdam FL, Ballieux BE, Guchelaar H, Pereira AM Abstract No abstract available. PMID: 22173367 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5517103 Thu, 01 Dec 2011 05:00:00 +0100 5517103 http://www.medworm.com/index.php?rid=5517102&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22173368%26dopt%3DAbstract Authors: Jongman JK, Ramdat Misier AR Abstract No abstract available. PMID: 22173368 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5517102 Thu, 01 Dec 2011 05:00:00 +0100 5517102 http://www.medworm.com/index.php?rid=5517101&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22173369%26dopt%3DAbstract Authors: Hovius JW, Wagner R, Ziegler J, Mehlhorn H, Grobusch MP Abstract No abstract available. PMID: 22173369 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5517101 Thu, 01 Dec 2011 05:00:00 +0100 5517101 http://www.medworm.com/index.php?rid=5517100&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22173370%26dopt%3DAbstract Authors: Wang H, Lu RC, Liang J Abstract No abstract available. PMID: 22173370 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5517100 Thu, 01 Dec 2011 05:00:00 +0100 5517100 http://www.medworm.com/index.php?rid=5383784&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22058259%26dopt%3DAbstract Authors: Levi MM Abstract No abstract available. PMID: 22058259 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5383784 Sat, 01 Oct 2011 04:00:00 +0100 5383784 http://www.medworm.com/index.php?rid=5383783&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22058260%26dopt%3DAbstract Authors: Hak AE, de Paepe B, de Bleecker JL, Tak PP, de Visser M Abstract Polymyositis (PM) and dermatomyositis (DM) are rare idiopathic inflammatory myopathies (IIM) with a presumed autoimmune pathogenesis. Typical features are subacute onset, proximal, symmetric muscle weakness, elevated serum creatine kinase, and mononuclear cell infiltrates in the muscle biopsy. Strong support for an autoimmune pathogenesis comes from histopathological findings in biopsies of affected muscles. Furthermore, the association with autoantibodies supports the notion that immune-mediated inflammation is involved. PM and DM may occur in isolation or in connection with a connective tissue disease or cancer. The current treatment for IIM consists of first-line high-dose steroids and various conventional... The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5383783 Sat, 01 Oct 2011 04:00:00 +0100 5383783 http://www.medworm.com/index.php?rid=5383782&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22058261%26dopt%3DAbstract Authors: Kater AP, Wittebol S, Chamuleau ME, van Gelder M, J van Oers MH, Behalf Of The Hovon Cll Working Party O Abstract One of the principal responsibilities of the Chronic Lymphocytic Leukaemia (CLL) Working Party of the Dutch÷Belgium Haemato-Oncology Foundation for Adults in the Netherlands (HOVON) is to create up-to-date guidelines for CLL . In this article, the revised guidelines for diagnosis and treatment are summarised. Despite recent expansion in treatment options for patients with CLL , the disease remains incurable in most cases and the optimal treatment approach for several subgroups of patients is still unclear. Therefore, it remains highly important to treat patients within clinical studies as much as possible. In this article, the current studies initiated by the ... The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5383782 Sat, 01 Oct 2011 04:00:00 +0100 5383782 http://www.medworm.com/index.php?rid=5383781&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22058262%26dopt%3DAbstract Authors: Thielen N, Ossenkoppele GJ, Schuurhuis GJ, Janssen JJ Abstract No abstract available. PMID: 22058262 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5383781 Sat, 01 Oct 2011 04:00:00 +0100 5383781 http://www.medworm.com/index.php?rid=5383780&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22058263%26dopt%3DAbstract Authors: Bilgin YM, van de Watering LM, Brand A Abstract For many years filtration for removal of leucocytes from red blood cell (RBC) and platelet transfusions was applied for selected patients to prevent cytomegalovirus (CMV) (re)activation, HLA immunisation and recurrent febrile nonhaemolytic transfusion reactions (FNHTR ). Since the 1980s, there was also growing concern about cancer recurrence and postoperative infections. In this review we discuss the studies on possible benefits of leucoreduction. In 2001 the Dutch Health Council decided that all blood products should undergo leucoreduction by filtration, as a precautionary measure to reduce possible transmission of variant Creutzfeld-Jacob disease (vCJD). The incidences of transfusion-transmitted CMV infection, HLA immunisat... The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5383780 Sat, 01 Oct 2011 04:00:00 +0100 5383780 http://www.medworm.com/index.php?rid=5383779&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22058264%26dopt%3DAbstract Authors: Popa C, Dekker HM, van Deuren M Abstract No abstract available. PMID: 22058264 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5383779 Sat, 01 Oct 2011 04:00:00 +0100 5383779 http://www.medworm.com/index.php?rid=5383778&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22058265%26dopt%3DAbstract Authors: Moret M, Schouten WE, Hoekzema R, van den Berk GE Abstract No abstract available. PMID: 22058265 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5383778 Sat, 01 Oct 2011 04:00:00 +0100 5383778 http://www.medworm.com/index.php?rid=5383777&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22058266%26dopt%3DAbstract Authors: Verweij KE, de Jongh FE Abstract No abstract available. PMID: 22058266 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5383777 Sat, 01 Oct 2011 04:00:00 +0100 5383777 http://www.medworm.com/index.php?rid=5383776&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22058267%26dopt%3DAbstract Authors: Wilting KR, Kampinga GA, van Leeuwen JT, Slart RH, Sprenger HG Abstract No abstract available. PMID: 22058267 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5383776 Sat, 01 Oct 2011 04:00:00 +0100 5383776 http://www.medworm.com/index.php?rid=5383775&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22058268%26dopt%3DAbstract Authors: Drion I, Joosten H, Groenier KH, Lieverse AG, Kleefstra N, Wetzels JF, Bilo HJ Abstract No abstract available. PMID: 22058268 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5383775 Sat, 01 Oct 2011 04:00:00 +0100 5383775 http://www.medworm.com/index.php?rid=5383774&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22058269%26dopt%3DAbstract Authors: Bierhoff M, Krutwagen E, van Bommel EF, Verburgh CA Abstract Two cases are reported of patients on continuous ambulatory peritoneal dialysis who presented with peritonitis caused by Listeria monocytogenes. They were successfully treated with intraperitoneal and intravenous administration of amoxicillin. In patients on peritoneal dialysis, Listeria monocytogenes is a very rare cause of peritonitis, with only 11 cases reported to date, and mainly occurring in immunocompromised patients. In contrast to the majority of the reported cases, neither of our patients had received immunosuppressive drugs. To our knowledge, these are the first two cases of Listeria peritonitis reported in the Netherlands. PMID: 22058269 [PubMed - in process] (Source: The Netherlands Journal of Me... The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5383774 Sat, 01 Oct 2011 04:00:00 +0100 5383774 http://www.medworm.com/index.php?rid=5383773&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22058270%26dopt%3DAbstract Authors: Frijstein G, Hortensius J, Zaaijer HL Abstract To implement adequate preventive measures in a hospital, the number and nature of occupational exposures to blood must be known. In the Amsterdam Academic Medical Centre a standardised procedure was used to assess all reported occupational exposures to blood from 2003 to 2010. 1601 incidents were reported of which 66% were needlestick accidents. Thirty-five percent of the incidents concerned persons in training and 27% concerned experienced nurses. Twenty-nine percent of accidents occurred during cleaning up after a medical procedure, including the recapping of needles in 6%. In 8% of the accidents the patient was known or found to be infected with hepatitis B or C virus or HIV and in 86% of accidents the personnel were immune... The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5383773 Sat, 01 Oct 2011 04:00:00 +0100 5383773 http://www.medworm.com/index.php?rid=5383772&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22058271%26dopt%3DAbstract Authors: Hazenberg MD, Biemond BJ, Pals ST, Zumpolle CM, Schinkel CJ, Linthorst GE, Hoekstra JB, Vos JM Abstract No abstract available. PMID: 22058271 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5383772 Sat, 01 Oct 2011 04:00:00 +0100 5383772 http://www.medworm.com/index.php?rid=5302313&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21978976%26dopt%3DAbstract Authors: Schouten WE Abstract No abstract available. PMID: 21978976 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5302313 Thu, 01 Sep 2011 04:00:00 +0100 5302313 http://www.medworm.com/index.php?rid=5302312&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21978977%26dopt%3DAbstract Authors: Szekanecz Z, Koch AE, Tak PP Abstract Chemokines and chemokine receptors have been implicated in inflammatory cell recruitment and angiogenesis underlying the pathogenesis of rheumatoid arthritis (RA) and other inflammatory rheumatic diseases. Numerous CXC, CC, C and CX3C chemokines and their receptors have been detected in the arthritic synovium and numerous strategies, including biologics, peptide and other small molecule inhibitors of chemokines and their receptors have given promising results in preclinical studies performed in animal models of arthritis. However, most recent human RA trials using antibodies and synthetic compounds have failed. Reasons for negative results of these RA trials include overlapping actions of multiple chemokines, dose-dependency, both anta... The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5302312 Thu, 01 Sep 2011 04:00:00 +0100 5302312 http://www.medworm.com/index.php?rid=5302311&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21978978%26dopt%3DAbstract Authors: van Gulick JJ, Gevers TJ, van Keimpema L, Drenth JP Abstract Autosomal dominant polycystic kidney disease (ADPKD) is a multisystem disorder. It is the most common genetic cause of end-stage renal disease. One frequent extra-renal manifestation is hepatic cyst formation. The majority of ADPKD patients develop complications as a result of renal cyst formation; however, a small proportion develop extensive hepatic disease with minor renal features. Both phenotypes seem to represent the spectrum of ADPKD. This review discusses the current understanding of the pathogenesis of the disease, its manifestations and the mechanisms of cyst formation. Furthermore, it focuses on monitoring the disease and the treatment options currently available. PMID: 21978978 [PubMed - ... The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5302311 Thu, 01 Sep 2011 04:00:00 +0100 5302311 http://www.medworm.com/index.php?rid=5302310&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21978979%26dopt%3DAbstract Authors: Kuipers RS, de Graaf DJ, Luxwolda MF, Muskiet MH, Dijck-Brouwer DA, Muskiet FA Abstract The dietary intake of saturated fatty acids (SAFA) is associated with a modest increase in serum total cholesterol, but not with cardiovascular disease (CVD). Replacing dietary SAFA with carbohydrates (CHO), notably those with a high glycaemic index, is associated with an increase in CVD risk in observational cohorts, while replacing SAFA with polyunsaturated fatty acids (PUFA) is associated with reduced CVD risk. However, replacing a combination of SAFA and trans-fatty acids with n-6 PUFA (notably linoleic acid) in controlled trials showed no indication of benefit and a signal toward increased coronary heart disease risk, suggesting that n-3 PUFA may be responsible for the protective a... The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5302310 Thu, 01 Sep 2011 04:00:00 +0100 5302310 http://www.medworm.com/index.php?rid=5302309&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21978980%26dopt%3DAbstract Authors: Gupta A, Biyani M, Khaira A Abstract Vancomycin is a key antibiotic in the management of severe Gram-positive infections. Recent emergence of methicillin-resistant staphylococcal strains with reduced susceptibility to vancomycin has prompted internists to administer high-dose treatment to achieve trough levels of 15 to 20 mg÷l. Such high doses might be causative in nephrotoxicity. The risk further increases in patients who are critically ill and are on vasopressor support and÷or concomitant nephrotoxic agents, with baseline deranged renal function, undergoing prolonged duration of therapy and are obese. However, data are insufficient to recommend the superiority of continuous infusion regimens as compared with intermittent dosing. This review discusses the literature per... The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5302309 Thu, 01 Sep 2011 04:00:00 +0100 5302309 http://www.medworm.com/index.php?rid=5302308&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21978981%26dopt%3DAbstract Authors: Jansen L, Leffers P, Hermans M, Stassen P, Masclee A, Keulemans Y Abstract No abstract available. PMID: 21978981 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5302308 Thu, 01 Sep 2011 04:00:00 +0100 5302308 http://www.medworm.com/index.php?rid=5302307&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21978982%26dopt%3DAbstract Authors: Prins MC, van Meijel JJ Abstract A patient with valproic acid induced hyperammonaemic encephalopathy is presented. During chronic treatment with valproic acid this patient developed a potentially life-threatening encephalopathy without signs of liver failure. After discontinuing the valproic acid the patient recovered completely. In the case of a patient presenting with hyperammonaemic encephalopathy, the possibility of the use of valproic acid should not be overlooked. PMID: 21978982 [PubMed - in process] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5302307 Thu, 01 Sep 2011 04:00:00 +0100 5302307 http://www.medworm.com/index.php?rid=5302306&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21978983%26dopt%3DAbstract This study investigates the length of time spent in the ED (time to completion) and the factors contributing to prolonged stay in an academic ED. Data of ED patients were prospectively collected during four weeks in February 2010. Presentation time, referrer, discharge destination, and medical specialities involved were registered in 2510 patients. Additional detailed data about relevant time steps were collected from 66 patients in the triage category Emergency Severity Index (ESI) 3. The Pearson's chi-square test and the Mann-Whitney test were used for statistical analysis. Time to completion was longer than four hours in 13% of patients (average in total population 2:23 hours). In ESI 3 patients, 24% stayed longer than four hours in the ED (p. PMID: 21978983 [PubMed - in process] (S... The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5302306 Thu, 01 Sep 2011 04:00:00 +0100 5302306 http://www.medworm.com/index.php?rid=5302305&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21978984%26dopt%3DAbstract Authors: van Asseldonk EJ, de Sévaux RG, Flucke UE, de Rooy JW, Netea-Maier RT, Timmers HJ Abstract No abstract available. PMID: 21978984 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5302305 Thu, 01 Sep 2011 04:00:00 +0100 5302305 http://www.medworm.com/index.php?rid=5302304&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21978985%26dopt%3DAbstract Authors: van Pelt ED, den Hollander JC, de Vries HJ, van Beek Y, Melles DC, van der Meijden WI, van Genderen PJ Abstract No abstract available. PMID: 21978985 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5302304 Thu, 01 Sep 2011 04:00:00 +0100 5302304 http://www.medworm.com/index.php?rid=5302303&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21978986%26dopt%3DAbstract Authors: Poel YH, Slieker WA, Visser HP Abstract No abstract available. PMID: 21978986 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5302303 Thu, 01 Sep 2011 04:00:00 +0100 5302303 http://www.medworm.com/index.php?rid=5302302&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21978987%26dopt%3DAbstract Authors: Shaulov A, Benenson S, Cahan A, Hiller N, Korem M Abstract No abstract available. PMID: 21978987 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5302302 Thu, 01 Sep 2011 04:00:00 +0100 5302302 http://www.medworm.com/index.php?rid=5249836&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21934173%26dopt%3DAbstract Authors: Levi M Abstract No abstract available. PMID: 21934173 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5249836 Mon, 01 Aug 2011 04:00:00 +0100 5249836 http://www.medworm.com/index.php?rid=5249835&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21934174%26dopt%3DAbstract Authors: Soeters MR, van Zeijl CJ, Boelen A, Kloos R, Saeed P, Vriesendorp TM, Mourits MP Abstract Graves' thyroid disease is a relatively common disorder in endocrinology and general internal medicine practice. Graves' hyperthyroidism is mediated by circulating stimulating autoantibodies. Up to 60% of patients with Graves' hyperthyroidism develop some form of Graves' orbitopathy. Immune reactivity to the thyroid-stimulating hormone receptor is also thought to play a role in the immunopathogenesis of Graves' orbitopathy. Graves' orbitopathy is characterised by a wide open eye appearance, caused by upper eyelid retraction and soft-tissue swelling that causes exophthalmus. Symptoms include photophobia, sandy feeling in the eye, painful eye movements and diplopia. Visual acuity may be... The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5249835 Mon, 01 Aug 2011 04:00:00 +0100 5249835 http://www.medworm.com/index.php?rid=5249834&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21934175%26dopt%3DAbstract Authors: van Loon IN, Lamberts J, Valk GD, Muller AF Abstract The differential diagnosis of spells is broad and includes both innocent and life-threatening conditions with a considerable overlap in clinical presentation. Extensive diagnostic testing is often performed, without reaching a final diagnosis, or resulting in false-positives. A thorough medical history, including family history and medication, and physical examination are required to obtain clues about the cause of a spell. An overview of spells with their stereotypic phenotype in general internal medicine practice is presented in this article. Besides, a diagnostic approach is proposed for the clinical evaluation of spells. PMID: 21934175 [PubMed - in process] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5249834 Mon, 01 Aug 2011 04:00:00 +0100 5249834 http://www.medworm.com/index.php?rid=5249833&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21934176%26dopt%3DAbstract Conclusion: There is no clear definition for the alcohol-induced pseudo-Cushing state, and hitherto studies fail to provide clues to differentiate between pseudo-Cushing and Cushing's syndrome. Only cessation of alcohol can normalise biochemical abnormalities and regress hypercortisolic symptoms. PMID: 21934176 [PubMed - in process] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5249833 Mon, 01 Aug 2011 04:00:00 +0100 5249833 http://www.medworm.com/index.php?rid=5249832&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21934177%26dopt%3DAbstract Authors: Coolen A, Leunen K, Menten J, van Steenbergen W, Neven P Abstract We review the sensitivity of different diagnostic tests for breast cancer management based on recent experience in a 34-year-old patient. False-negative tests at diagnosis of early disease and of relapse resulted in diagnostic and therapeutic delays. Initial mammography and breast ultrasonography were falsely negative despite a palpable breast lump. Clinical examination and axillary ultrasound missed macroscopically involved lymph nodes. At relapse, metastatic lesions were missed despite symptoms, three years after primary treatment. CA 15-3 was normal; bone and liver metastases were missed by standard and more advanced imaging techniques including liver ultrasonography, nuclear bone scan and PET -C... The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5249832 Mon, 01 Aug 2011 04:00:00 +0100 5249832 http://www.medworm.com/index.php?rid=5249831&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21934178%26dopt%3DAbstract Conclusion: COMT SNP s and diplotypes are not associated with chronic pancreatitis. As a consequence, our results do not support a significant role for the COMT gene in chronic pancreatitis. PMID: 21934178 [PubMed - in process] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5249831 Mon, 01 Aug 2011 04:00:00 +0100 5249831 http://www.medworm.com/index.php?rid=5249830&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21934179%26dopt%3DAbstract Authors: Vos FJ, Bleeker-Rovers CP, Sturm PD, Krabbe PF, van Dijk AP, Oyen WJ, Kullberg BJ Abstract Background: Despite firm recommendations to perform echocardiography in high-risk patients with Gram-positive bacteraemia, routine echocardiography is not embedded in daily practice in many settings. The aim of this study was to evaluate whether a regime including routine echocardiography results in better outcome. Methods: A total of 115 patients with Gram-positive bacteraemia and at least one risk factor for developing metastatic infection were prospectively included. Routine echocardiography was advocated and facilitated in these patients. Results were compared with a matched historical control group of 230 patients in whom echocardiography was performed at the discretion of the a... The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5249830 Mon, 01 Aug 2011 04:00:00 +0100 5249830 http://www.medworm.com/index.php?rid=5249829&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21934180%26dopt%3DAbstract We describe a 43-year-old woman who presented with a nephrotic syndrome. Renal biopsy revealed a membranous pattern of glomerular injury. In electron microscopy the subepithelial deposits were comprised of 40 nm wide tubular structures, confirming ITG . During follow-up the patient developed a remission of proteinuria with only supportive treatment. PMID: 21934180 [PubMed - in process] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5249829 Mon, 01 Aug 2011 04:00:00 +0100 5249829 http://www.medworm.com/index.php?rid=5249828&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21934181%26dopt%3DAbstract Authors: Nadery S, Leyten EM Abstract No abstract available. PMID: 21934181 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5249828 Mon, 01 Aug 2011 04:00:00 +0100 5249828 http://www.medworm.com/index.php?rid=5249827&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21934182%26dopt%3DAbstract Authors: Desar IM, Stevens WB, Verweij PE, van der Velden WJ Abstract No abstract available. PMID: 21934182 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5249827 Mon, 01 Aug 2011 04:00:00 +0100 5249827 http://www.medworm.com/index.php?rid=5249826&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21934183%26dopt%3DAbstract Authors: Verweij KE, Engelkens HJ, Bertheux CA, Dees A Abstract No abstract available. PMID: 21934183 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5249826 Mon, 01 Aug 2011 04:00:00 +0100 5249826 http://www.medworm.com/index.php?rid=5249825&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21934184%26dopt%3DAbstract Authors: Oude Lansink-Hartgring A, Ismael F Abstract No abstract available. PMID: 21934184 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5249825 Mon, 01 Aug 2011 04:00:00 +0100 5249825 http://www.medworm.com/index.php?rid=5161290&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21868808%26dopt%3DAbstract Authors: de Rooij SE Abstract No abstract available. PMID: 21868808 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5161290 Tue, 31 May 2011 23:00:00 +0100 5161290 http://www.medworm.com/index.php?rid=5161289&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21868809%26dopt%3DAbstract In conclusion, many issues regarding the aetiology of anaemia in old age remain unresolved. Because current guidelines on anaemia are based on the classic notions of the aetiology of anaemia, they may need to be revised for the highest age groups. PMID: 21868809 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5161289 Tue, 31 May 2011 23:00:00 +0100 5161289 http://www.medworm.com/index.php?rid=5161288&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21868810%26dopt%3DAbstract Authors: Levi M, Eerenberg E, Kamphuisen PW Abstract Anticoagulants are effective agents in reducing the risk of thromboembolism but the most important adverse effect of these agents is the occurrence of bleeding. Bleeding complications may occur spontaneously but the risk of bleeding is particularly increased in case of trauma or around invasive procedures. If patients being treated with anticoagulants need to undergo an invasive intervention, physicians need to consider whether to interrupt the use of this medication or to allow its use to be continued. Suspending the use of anticoagulants increases the risk of thrombosis, whereas continued use may cause bleeding complications. To shorten the period in which anticoagulant treatment is interrupted, bridging strategies have been ad... The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5161288 Tue, 31 May 2011 23:00:00 +0100 5161288 http://www.medworm.com/index.php?rid=5161287&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21868811%26dopt%3DAbstract Authors: van der Kooij SM, Klint E, Hehenkamp WJ, Bipat S, Ankum WM, Reekers JA Abstract The validity of uterine artery embolisation (UAE ) as an alternative treatment for hysterectomy to treat symptomatic uterine fibroids has been well established. Despite its favourable outcomes, UAE is still only marginally applied in the Netherlands. The aim of this inventory is to identify factors which either restrict or facilitate the implementation of UAE. Gynaecologists and interventional-radiologists in three hospitals in Amsterdam were interviewed by means of questionnaires. One of these hospitals had ample experience in UAE for uterine fibroids, one hospital had just started providing this treatment, and one hospital did not perform UAE. Also patients with symptomatic fibroids who were ... The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5161287 Tue, 31 May 2011 23:00:00 +0100 5161287 http://www.medworm.com/index.php?rid=5161286&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21868812%26dopt%3DAbstract Authors: van der Wijk J, Smid2 WM, Seelen MA, van de Kar NC, Offerman JJ, van Son WJ Abstract A 33-year-old woman with a history of chronic transplant dysfunction because of repeated bouts of haemolytic uraemic syndrome (HUS) was considered for a second transplant. Extensive genetic investigation of the complement system was executed to rule out known mutations prone to development of HUS. This case illustrates the importance of genetic screening in patients with recurrent HUS. PMID: 21868812 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5161286 Tue, 31 May 2011 23:00:00 +0100 5161286 http://www.medworm.com/index.php?rid=5161285&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21868813%26dopt%3DAbstract Authors: Herkert JC, Blaauwwiekel EE, Hoek A, Veenstra-Knol HE, Kema IP, Arlt W, Kerstens MN Abstract Cytochrome P450 oxidoreductase (POR) deficiency is a recently discovered new variant of congenital adrenal hyperplasia. Distinctive features of POR deficiency are the presence of disorders of sexual development in both sexes, glucocorticoid deficiency and skeletal malformations similar to those observed in the Antley-Bixler syndrome. PMID: 21868813 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5161285 Tue, 31 May 2011 23:00:00 +0100 5161285 http://www.medworm.com/index.php?rid=5161284&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21868814%26dopt%3DAbstract Authors: Tuinman PR, Nieuwenhuis MB, Groen E, Kersten MJ Abstract No abstract available. PMID: 21868814 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5161284 Tue, 31 May 2011 23:00:00 +0100 5161284 http://www.medworm.com/index.php?rid=5161283&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21868815%26dopt%3DAbstract Authors: Goeijenbier M, Nur E, Goris M, Wagenaar JF, Grünberg K, Nurmohamed SA, Martina BE, Osterhaus AD, van Gorp EC Abstract No abstract available. PMID: 21868815 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5161283 Tue, 31 May 2011 23:00:00 +0100 5161283 http://www.medworm.com/index.php?rid=5161282&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21868816%26dopt%3DAbstract Authors: Appelman-Dijkstra NM, Pereira AM, Smit VT, Kapiteijn E Abstract No abstract available. PMID: 21868816 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5161282 Tue, 31 May 2011 23:00:00 +0100 5161282 http://www.medworm.com/index.php?rid=5161281&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21868817%26dopt%3DAbstract Authors: Dutilh JC, Taljaard JJ Abstract No abstract available. PMID: 21868817 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5161281 Tue, 31 May 2011 23:00:00 +0100 5161281 http://www.medworm.com/index.php?rid=5161280&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21868818%26dopt%3DAbstract Authors: Tromp M, Tjan DH, van Zanten AR, Gielen-Wijffels SE, Goekoop GJ, van den Boogaard M, Wallenborg CM, Biemond-Moeniralam HS, Pickkers P Abstract To reduce unintentional and avoidable adverse events in patients in hospitals in the Netherlands, a patient safety agency (VMS) programme was launched in 2008. Among the VMS topics, the programme 'optimal therapy in severe sepsis', according to the international Surviving Sepsis Campaign (SSC), aims to improve early diagnosis and treatment of sepsis to reduce sepsis mortality by 15% before the end of 2012. We analysed compliance data submitted to the international SSC database from the Netherlands and compared these data with published international SS C results. Data of 863 patients, representing 6% of the international data (n=14,... The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5161280 Tue, 31 May 2011 23:00:00 +0100 5161280 http://www.medworm.com/index.php?rid=5118548&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21793262%26dopt%3DAbstract We describe involvement of the heart in patients with hypereosinophilic syndrome,and the diagnostic and therapeutic clinical management of these patients. PMID: 21793262 [PubMed - in process] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=5118548 Sat, 30 Apr 2011 23:00:00 +0100 5118548 http://www.medworm.com/index.php?rid=4925364&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21646666%26dopt%3DAbstract Authors: Zaaijer HL No abstract available. PMID: 21646666 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4925364 Sat, 30 Apr 2011 23:00:00 +0100 4925364 http://www.medworm.com/index.php?rid=4925363&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21646667%26dopt%3DAbstract Authors: Vlaar AP, Rietdijk ST, Zeerleder SS, Boerman T, Beuers U Hepatocellular carcinoma (HCC) is a well-known consequence of hepatitis C virus (HCV) infection mainly in cirrhotic patients. Associations of other malignancies such as cholangiocellular carcinoma and B-cell malignancies with HCV are less well known. Here we review pathophysiological aspects of malignancies associated with HCV infection. A case report of HCV-related HCC and B-cell lymphoma illustrates the increased risk for HCV-infected patients to develop other malignancies besides HCC. PMID: 21646667 [PubMed - in process] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4925363 Sat, 30 Apr 2011 23:00:00 +0100 4925363 http://www.medworm.com/index.php?rid=4925362&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21646668%26dopt%3DAbstract Conclusion: Prolonged 72-week treatment should be considered in HCV genotype 1 patients without RVR at week 4, as this increased SVR. PMID: 21646668 [PubMed - in process] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4925362 Sat, 30 Apr 2011 23:00:00 +0100 4925362 http://www.medworm.com/index.php?rid=4925361&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21646669%26dopt%3DAbstract Authors: Heijne A, Gerhards MF, Blomjous JG, van der Sluys Veer A PMID: 21646669 [PubMed - in process] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4925361 Sat, 30 Apr 2011 23:00:00 +0100 4925361 http://www.medworm.com/index.php?rid=4925360&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21646670%26dopt%3DAbstract Authors: Popa C, Wever PC, Moviat M PMID: 21646670 [PubMed - in process] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4925360 Sat, 30 Apr 2011 23:00:00 +0100 4925360 http://www.medworm.com/index.php?rid=4925359&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21646671%26dopt%3DAbstract Authors: Kwakkel J, Fliers E, Boelen A During illness changes in thyroid hormone metabolism occur, collectively known as the non-thyroidal illness syndrome (NTIS). NTIS is characterised by low serum thyroid hormone levels without the expected rise in serum thyroid-stimulating hormone, indicating a major change in thyroid hormone feedback regulation. Recent studies have made clear that during NTIS differential changes in thyroid hormone metabolism occur in various tissues, the net effect of which may be either activation or inhibition of thyroid hormone action. In this review we discuss systemic and local changes in thyroid hormone metabolism during illness, highlighting their physiological implications in terms of disease course. PMID: 21646671 [PubMed - in process] (Source: The Ne... The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4925359 Sat, 30 Apr 2011 23:00:00 +0100 4925359 http://www.medworm.com/index.php?rid=4925358&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21646672%26dopt%3DAbstract Conclusion: Despite extensive adjustments, a clinically relevant, statistically significant difference between hospitals was found in standardised BP measurements at baseline of a randomised controlled study. We hypothesise that differences in the approach towards BP control exist at the physician level and that these explain the differences between hospitals. PMID: 21646672 [PubMed - in process] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4925358 Sat, 30 Apr 2011 23:00:00 +0100 4925358 http://www.medworm.com/index.php?rid=4925357&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21646673%26dopt%3DAbstract Authors: Geijteman E, Kramer M, Nanayakkara P Although anecdotal reports pointing to the occurrence of episodes of shortness of breath due to prednisone use have been published, systematic evidence is lacking. In this manuscript we report on an n=1 trial in a patient using prednisone for polymyalgia rheumatica. With this approach we can confirm that prednisone may cause episodes of dyspnoea and we provide potential explanations for this side effect. PMID: 21646673 [PubMed - in process] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4925357 Sat, 30 Apr 2011 23:00:00 +0100 4925357 http://www.medworm.com/index.php?rid=4925356&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21646674%26dopt%3DAbstract Authors: Fassaert T, Jager G PMID: 21646674 [PubMed - in process] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4925356 Sat, 30 Apr 2011 23:00:00 +0100 4925356 http://www.medworm.com/index.php?rid=4925355&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21646675%26dopt%3DAbstract Authors: van den Born BJ, Beutler JJ, Gaillard CA, de Gooijer A, van den Meiracker AH, Kroon AA Hypertensive crises are divided into hypertensive urgencies and emergencies. Together they form a heterogeneous group of acute hypertensive disorders depending on the presence or type of target organs involved. Despite better treatment options for hypertension, hypertensive crisis and its associated complications remain relatively common. In the Netherlands the number of patients starting renal replacement therapy because of 'malignant hypertension' has increased in the past two decades. In 2003, the first Dutch guideline on hypertensive crisis was released to allow a standardised evidence-based approach for patients presenting with a hypertensive crisis. In this paper we give an overview of... The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4925355 Sat, 30 Apr 2011 23:00:00 +0100 4925355 http://www.medworm.com/index.php?rid=4925354&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21646676%26dopt%3DAbstract Authors: Wismans PJ, van Genderen PJ PMID: 21646676 [PubMed - in process] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4925354 Sat, 30 Apr 2011 23:00:00 +0100 4925354 http://www.medworm.com/index.php?rid=4827660&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21566247%26dopt%3DAbstract Authors: de Pont AC, de Jager CP, van den Bergh WM, Schultz MJ A diver was resuscitated after cardiac arrest due to near drowning and was hypothermic on hospital arrival. During rewarming, status epilepticus occurred, previously identified as a predictor of poor outcome. The seizures responded well to treatment with antiepileptic drugs and controlled hypothermia. After six weeks, the patient had completely recovered. This case supports the hypothesis that hypothermia offers neuroprotection, even in the presence of status epilepticus. We recommend that near-drowning victims who are comatose after resuscitation for cardiac arrest be treated with controlled mild hypothermia for 12 to 24 hours. PMID: 21566247 [PubMed - in process] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4827660 Thu, 31 Mar 2011 23:00:00 +0100 4827660 http://www.medworm.com/index.php?rid=4771902&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21527801%26dopt%3DAbstract Authors: Serlie MJ, La Fleur SE, Fliers E No abstract available. PMID: 21527801 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4771902 Thu, 31 Mar 2011 23:00:00 +0100 4771902 http://www.medworm.com/index.php?rid=4771901&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21527802%26dopt%3DAbstract Authors: Pijl H This paper delineates the evolutionary background of the unprecedented epidemic of obesity that has evolved over the last century. Some two million years ago, a change of climate in the habitat of our primate ancestors triggered dietary adaptations which allowed our brain to grow. A shift from principally carbohydrate-based to fish- and meat-based eating habits provided sufficient fuel and building blocks to facilitate encephalisation. Insulin resistance may have evolved simultaneously as a means to avert the danger of hypoglycaemia to the brain (in view of the reduction of carbohydrate intake). Ensuing cognitive capacities enabled the control of fire and the manufacturing of tools, which increased energy yield from food even further and eased the defence against predat... The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4771901 Thu, 31 Mar 2011 23:00:00 +0100 4771901 http://www.medworm.com/index.php?rid=4771900&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21527803%26dopt%3DAbstract Authors: de Jonge HJ, Huls G, de Bont ES Acute myeloid leukaemia (AML) is a heterogeneous disease characterised by clonal malignant haematopoiesis with a differentiation arrest and excessive proliferation of leukaemic blasts. Over the past decades, the heterogeneity of AML has been illustrated by evolving classifications based on morphology (French-American-British classification (FAB classification), cytogenetic abnormalities (e.g. t(8;21), monosomies etc.), phenotype and÷or molecular abnormalities (e.g. Fms-like tyrosine kinase 3 gene internal tandem duplication (FLT3-ITD), mutations in nucleophosmin 1 (NPM1) and the transcription factor CCAAT ÷enhancer binding protein a (CEBPA), etc.). The current World Health Organisation (WHO) 2008 classification has integrated these cl... The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4771900 Thu, 31 Mar 2011 23:00:00 +0100 4771900 http://www.medworm.com/index.php?rid=4771899&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21527804%26dopt%3DAbstract Authors: Zeerleder S Autoimmune haemolytic anaemia (AIHA) is a rare disease. In clinical practice, diagnosis and treatment of AIHA turns out to be troublesome. Correct diagnosis is dependent on proper comprehension of the pathophysiology and the laboratory tests performed by the transfusion laboratory. The present review provides a short overview on the pathogenesis of autoimmune haemolytic anaemia. The diagnostic pitfalls will be discussed and a diagnostic algorithm for proper diagnosis of AI HA will be given. Moreover, a brief overview on the treatment of different forms of AIHA is given. PMID: 21527804 [PubMed - in process] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4771899 Thu, 31 Mar 2011 23:00:00 +0100 4771899 http://www.medworm.com/index.php?rid=4771898&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21527805%26dopt%3DAbstract Authors: van den Berge K No abstract available. PMID: 21527805 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4771898 Thu, 31 Mar 2011 23:00:00 +0100 4771898 http://www.medworm.com/index.php?rid=4771897&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21527806%26dopt%3DAbstract Authors: Mammatas LH, Stam F No abstract available. PMID: 21527806 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4771897 Thu, 31 Mar 2011 23:00:00 +0100 4771897 http://www.medworm.com/index.php?rid=4771896&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21527807%26dopt%3DAbstract This study describes the frequency of bradycardia (pulse rate. PMID: 21527807 [PubMed - in process] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4771896 Thu, 31 Mar 2011 23:00:00 +0100 4771896 http://www.medworm.com/index.php?rid=4771895&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21527808%26dopt%3DAbstract We report the case of a 64-year-old woman with breast cancer who developed severe symptomatic hyponatraemia with a generalised seizure and convulsions after a second cycle of adjuvant chemotherapy with 5-fluouracil, epirubicin and cyclophosphamide. She completely recovered after correction of the serum sodium concentration without neurological deficits. Physicians prescribing cyclophosphamide, irrespective of the treatment indication and dosage, should be aware of this potentially life-threatening complication. PMID: 21527808 [PubMed - in process] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4771895 Thu, 31 Mar 2011 23:00:00 +0100 4771895 http://www.medworm.com/index.php?rid=4771894&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21527809%26dopt%3DAbstract Authors: Vlaar AP, Kunst PW No abstract available. PMID: 21527809 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4771894 Thu, 31 Mar 2011 23:00:00 +0100 4771894 http://www.medworm.com/index.php?rid=4771893&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21527810%26dopt%3DAbstract Authors: Kolwijck E, Dofferhoff AS, van de Leur J, Meis JF A 51-year-old farm worker presented with jaundice and fever. There had been a rat infestation around the farm ponds and in the shed. He was admitted to our hospital with acute renal and liver failure, thrombocytopenia and rhabdomyolysis. Because of the clinical clues, leptospirosis was suspected and diagnosed in blood by polymerase chain reaction and serology. Also his son, a co-worker on the farm, showed a positive serology. Clinicians should be aware of these occupational outbreaks and should recognise the clinical picture. PMID: 21527810 [PubMed - in process] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4771893 Thu, 31 Mar 2011 23:00:00 +0100 4771893 http://www.medworm.com/index.php?rid=4771892&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21527811%26dopt%3DAbstract Authors: Lauw MN, Hoekstra JB, Linthorst GE Background: Clinical images and tests are considered useful tools to enhance the memorisation of facts and information in medical education. Therefore, we initiated a weekly medical quiz for our department of Internal Medicine. Methods: Every week, a new case on a single slide with relevant information and a representative image, is sent by e-mail to staff, residents and others. All are requested on a voluntary basis to e-mail the presumed diagnosis within one week. Results: After two years, 100 cases were presented to 452 registered participants. On average, only 33 of 452 (range 14 to 59) participants (7.3%; 95% CI 4.9 to 9.7) responded per case. Most presumed diagnoses were submitted on the same day the case was sent (OR 0.81&... The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4771892 Thu, 31 Mar 2011 23:00:00 +0100 4771892 http://www.medworm.com/index.php?rid=4771891&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21527812%26dopt%3DAbstract Authors: Vlasveld LT, van 't Wout J, Castel A No abstract available. PMID: 21527812 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4771891 Thu, 31 Mar 2011 23:00:00 +0100 4771891 http://www.medworm.com/index.php?rid=4723206&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21444933%26dopt%3DAbstract Authors: Kullberg BJ, Berende A, van der Meer JW No abstract available. PMID: 21444933 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4723206 Tue, 01 Mar 2011 00:00:00 +0100 4723206 http://www.medworm.com/index.php?rid=4723205&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21444934%26dopt%3DAbstract Authors: Coumou J, van der Poll T, Speelman P, Hovius JW Lyme borreliosis has become the most common vector-borne illness in North Eastern USA and Europe. It is a zoonotic disease, with well-defined symptoms, caused by B. burgdorferi sensu lato, and transmitted by ticks. Lyme borreliosis is endemic in the Netherlands with a yearly incidence of approximately 133 cases÷100,000 inhabitants. Similar to another spirochetal disease, syphilis, it can be divided into three stages; early, early disseminated and late disseminated manifestations of disease, of which the specific clinical presentations will be discussed in detail. The diagnosis of Lyme borreliosis is based on a history of potential exposure to ticks and the risk of infection with B. burgdorferi s.l., development of speci... The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4723205 Tue, 01 Mar 2011 00:00:00 +0100 4723205 http://www.medworm.com/index.php?rid=4723204&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21444935%26dopt%3DAbstract Authors: de Wijkerslooth TR, Bossuyt PM, Dekker E Colorectal cancer is the second most common cancer in Europe and meets the criteria for population screening. Population screening should lead to a reduction in CRC-related mortality and incidence. Several options are available for CRC screening, which can be itemised as stool-based tests and structural exams. Stool-based tests include guaiac and immunochemical faecal occult blood tests and DNA -marker tests. Structural exams comprise endoscopic techniques (flexible sigmoidoscopy, colonoscopy and capsule endoscopy) and radiological exams (double contrast barium enema, CT colonography and MR colonography). Each test has its own test performance characteristics and acceptability profile, which affect the participation and effectiveness of... The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4723204 Tue, 01 Mar 2011 00:00:00 +0100 4723204 http://www.medworm.com/index.php?rid=4723203&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21444936%26dopt%3DAbstract Discussion: Several theories concerning the mechanism for type B lactic acidosis in solid malignancy have been postulated. During the last decade, more and more evidence supports the role of overproduction of lactic acid due to ischaemia in the neoplastic tissue bed and with cancer cells having an aberrant energy production. PMID: 21444936 [PubMed - in process] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4723203 Tue, 01 Mar 2011 00:00:00 +0100 4723203 http://www.medworm.com/index.php?rid=4723202&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21444937%26dopt%3DAbstract Conclusion: A majority of the febrile patients were admitted to the hospital, mostly for bacterial infection. An overall mortality rate of 4.2% was registered. Only a few risk factors for adverse outcome could be identified in this cohort. Overall, the outcome of patients presenting with fever at the ED is rather benign. PMID: 21444937 [PubMed - in process] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4723202 Tue, 01 Mar 2011 00:00:00 +0100 4723202 http://www.medworm.com/index.php?rid=4723201&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21444938%26dopt%3DAbstract Authors: Volman MN, Ten Kate RW, Tukkie R Tako Tsubo cardiomyopathy is a serious condition that is caused by heart failure due to inordinate stress. We here present a case of a young woman with this disorder in association with anorexia nervosa. We postulate a pathophysiological relationship and discuss the management of Tako Tsubo cardiomyopathy. PMID: 21444938 [PubMed - in process] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4723201 Tue, 01 Mar 2011 00:00:00 +0100 4723201 http://www.medworm.com/index.php?rid=4723200&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21444939%26dopt%3DAbstract Authors: Schipper EM, Posthuma W, Snieders I, Brouwer RE Systemic mastocytosis may be accompanied by a second haematological malignancy, usually of myeloid origin. However, a number of case reports describe systemic mastocytosis coexisting with a second haematological malignancy of lymphoid origin. Here, we report a case of a 74-year-old man with systemic mastocytosis who developed a diffuse large B-cell lymphoma. A short overview of the literature concerning mastocytosis accompanied by a second haematological malignancy is presented. PMID: 21444939 [PubMed - in process] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4723200 Tue, 01 Mar 2011 00:00:00 +0100 4723200 http://www.medworm.com/index.php?rid=4723199&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21444940%26dopt%3DAbstract Authors: Silbermann MH, Munneke JM No abstract available. PMID: 21444940 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4723199 Tue, 01 Mar 2011 00:00:00 +0100 4723199 http://www.medworm.com/index.php?rid=4723198&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21444941%26dopt%3DAbstract Authors: van Munster BC, Baas MC No abstract available. PMID: 21444941 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4723198 Tue, 01 Mar 2011 00:00:00 +0100 4723198 http://www.medworm.com/index.php?rid=4723197&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21444942%26dopt%3DAbstract Authors: Naesens R, Magerman K, Cartuyvels R, Vanden Abeele M, van Renterghem K, Gyssens IC No abstract available. PMID: 21444942 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4723197 Tue, 01 Mar 2011 00:00:00 +0100 4723197 http://www.medworm.com/index.php?rid=4723196&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21444943%26dopt%3DAbstract Conclusion: Chronic pain occur s frequently, has a negative impact on the patient and society and treatment may not always be adequate. Chronic pain should be seen as an important public health problem deserving more attention of Dutch healthcare workers and policy makers. PMID: 21444943 [PubMed - in process] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4723196 Tue, 01 Mar 2011 00:00:00 +0100 4723196 http://www.medworm.com/index.php?rid=4669412&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21444944%26dopt%3DAbstract Authors: van Veenendaal A, Baten A, Pickkers P No abstract available. PMID: 21444944 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4669412 Tue, 01 Mar 2011 00:00:00 +0100 4669412 http://www.medworm.com/index.php?rid=4611504&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21411839%26dopt%3DAbstract Authors: Smulders Y No abstract available. PMID: 21411839 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4611504 Tue, 01 Feb 2011 00:00:00 +0100 4611504 http://www.medworm.com/index.php?rid=4611503&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21411840%26dopt%3DAbstract Authors: Wouters MM, Boeckxstaens GE The enteric nervous system regulates diverse functions including gastrointestinal motility and nociception. The sensory neurons detect mechanical and chemical stimuli while motor neurons control peristalsis and secretion. In addition to this extensive neuronal network, the gut also houses a highly specialised immune system which plays an important role in the induction and maintenance of tolerance to food and other luminal antigens and in the protection of the epithelial barrier against pathogenic invasion. It is now increasingly recognised that the gastrointestinal immune system and the enteric nervous system closely interact. This review will focus on two common functional gastrointestinal disorders in which neuroimmune interaction is involved in ... The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4611503 Tue, 01 Feb 2011 00:00:00 +0100 4611503 http://www.medworm.com/index.php?rid=4611502&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21411841%26dopt%3DAbstract Authors: de Joode AA, Sluiter HE A 28-year-old young woman was referred to our department of Internal Medicine for analysis of unintentional weight loss. At initial analysis, a persistent proteinuria was found with no evident relation to her weight loss. Anamnestic as well as additional studies showed no evidence of a primary kidney disease. After this exclusion, orthostatic proteinuria was confirmed by simple urine analysis. Since the weight loss had not yet been explained, an analysis followed at the Department of Gastointestinal and Liver Diseases where inflammatory bowel disease (IBD) was found. Literature study shows that proteinuria may be associated with IBD. This concerns mainly selective tubular protein loss, without a distinctive change in protein loss with a change in positi... The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4611502 Tue, 01 Feb 2011 00:00:00 +0100 4611502 http://www.medworm.com/index.php?rid=4611501&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21411842%26dopt%3DAbstract Authors: de Graaff LC, Martín-Martorell P, Baan J, Ballieux B, Smit JW, Radder JK Objective: Diabetes mellitus type 1 (DM1) is associated with other autoimmune disorders. To our knowledge, there are no longitudinal data considering the long-term clinical relevance of organ-specific antibodies (OS-Ab) in DM1 patients. We performed a long-term retrospective longitudinal study in order to investigate the presence and diagnostic accuracy (positive predictive value: PPV and negative predictive value: NPV) of OS-Ab in DM1 patients. Research design and methods: In a retrospective longitudinal study, the presence of OS-Ab and related organ function were analysed in 396 DM1 patients (184 F÷212 M, age 44±13 years, age at onset of DM1 21±13 years), with a median follow-up time of 23±10 years... The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4611501 Tue, 01 Feb 2011 00:00:00 +0100 4611501 http://www.medworm.com/index.php?rid=4611500&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21411843%26dopt%3DAbstract Authors: Haas RL, de Klerk G Radiation recall dermatitis (RRD) is a rare cutaneous reaction occurring within a previously irradiated field, precipitated by certain drugs. A case of RRD most likely induced by doxorubicin is presented and illustrated together with a review of the literature. PMID: 21411843 [PubMed - in process] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4611500 Tue, 01 Feb 2011 00:00:00 +0100 4611500 http://www.medworm.com/index.php?rid=4611499&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21411844%26dopt%3DAbstract We present a case of HSV oesophagitis in a pregnant woman. A possible explanation for HSV oesophagitis during pregnancy is the decreased cellular immunity, leading to an increased frequency and severity of viral infections. Antiviral therapy is advocated in pregnancy. PMID: 21411844 [PubMed - in process] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4611499 Tue, 01 Feb 2011 00:00:00 +0100 4611499 http://www.medworm.com/index.php?rid=4611498&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21411845%26dopt%3DAbstract We describe a case in which serum creatinine is elevated due to the use of creatine ethyl esther. One week after withdrawal, the plasma creatinine had normalised. There are two types of creatine products available: creatine ethyl esther (CEE) and creatine monohydrate (CM). Plasma creatinine is not elevated in all creatine-using subjects. CEE , but not CM, is converted into creatinine in the gastrointestinal tract. As a result the use of CEE may be associated with elevated plasma creatinine levels. Since plasma creatinine is a widely used marker for renal function, the use of CEE may lead to a false assumption of renal failure. PMID: 21411845 [PubMed - in process] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4611498 Tue, 01 Feb 2011 00:00:00 +0100 4611498 http://www.medworm.com/index.php?rid=4611497&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21411846%26dopt%3DAbstract Authors: Heijmen L, Vehof J, van Laarhoven HW No abstract available. PMID: 21411846 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4611497 Tue, 01 Feb 2011 00:00:00 +0100 4611497 http://www.medworm.com/index.php?rid=4611496&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21411847%26dopt%3DAbstract Authors: van Gorselen EO, Gerding MN No abstract available. PMID: 21411847 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4611496 Tue, 01 Feb 2011 00:00:00 +0100 4611496 http://www.medworm.com/index.php?rid=4611495&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21411848%26dopt%3DAbstract Authors: Beukhof CM, van Biezen FC, de Herder WW No abstract available. PMID: 21411848 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4611495 Tue, 01 Feb 2011 00:00:00 +0100 4611495 http://www.medworm.com/index.php?rid=4611494&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21411849%26dopt%3DAbstract Conclusions: Doctors and nurses have embraced the EBP paradigm as an important means to improve quality of clinical patient care, but its application is still cumbersome. This paper offers a tailored programme for implementation and managerial role-models.sustainment of EBP, corroborated by professional and managerial role-models. PMID: 21411849 [PubMed - in process] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4611494 Tue, 01 Feb 2011 00:00:00 +0100 4611494 http://www.medworm.com/index.php?rid=4611493&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21411850%26dopt%3DAbstract Authors: van de Veerdonk FL, Netea MG, Dinarello CA, van der Meer JW No abstract available. PMID: 21411850 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4611493 Tue, 01 Feb 2011 00:00:00 +0100 4611493 http://www.medworm.com/index.php?rid=4611492&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21411851%26dopt%3DAbstract Authors: van Deuren M, Verhagen M, Weemeas C No abstract available. PMID: 21411851 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4611492 Tue, 01 Feb 2011 00:00:00 +0100 4611492 http://www.medworm.com/index.php?rid=4494994&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21325694%26dopt%3DAbstract Authors: Levi M No abstract available. PMID: 21325694 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4494994 Sat, 01 Jan 2011 00:00:00 +0100 4494994 http://www.medworm.com/index.php?rid=4494989&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21325695%26dopt%3DAbstract Authors: Bijl M, Kallenberg CG, van Assen S Among immunocompromised patients morbidity and mortality due to vaccine-preventable infections is high. Although vaccination seems indicated, controversy exists about which vaccines should be offered, at what moment, and to whom. Guidelines are needed as the number of immunocompromised individuals increases due to the wider use of immunosuppressive drugs and, in particular, because since the introduction of biological agents, the spectrum of immunosuppressive drugs is rapidly expanding. In this review we will highlight controversies about vaccination in immunocompromised patients and will discuss indications for the several vaccines available to prevent infectious diseases with the focus on patients with autoimmune-inflammatory diseases. ... The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4494989 Sat, 01 Jan 2011 00:00:00 +0100 4494989 http://www.medworm.com/index.php?rid=4494984&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21325696%26dopt%3DAbstract Authors: Kuiper P, Verspaget HW, Overbeek LI, Biemond I, Lamers CB Neuroendocrine tumours of the gastroenteropancreatic tract (GEP-NETs) comprise a group of very heterogeneous neoplasms, which are considered 'rare diseases'. Epidemiological studies on the incidence of GEP-NETs worldwide have reported a remarkable increase in the detection of these tumours. In a recent study, based on pathology reports (PALGA) to investigate the incidence of pancreatic and duodenal neuroendocrine tumours in the Netherlands from 1991 until 2009, we also noticed a significant increase in the incidence of these tumours. In particular, the incidence of non-functioning neuroendocrine tumours had significantly increased over this period. Remarkably, a substantial discrepancy was observed between the numbers o... The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4494984 Sat, 01 Jan 2011 00:00:00 +0100 4494984 http://www.medworm.com/index.php?rid=4494978&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21325697%26dopt%3DAbstract Authors: Meijvis SC, Grutters JC, Thijsen SF, Rijkers GT, Biesma DH, Endeman H Community-acquired pneumonia (CAP) is a common and serious disease with significant mortality, morbidity and associated healthcare costs. Severity of pneumonia is related to the extent of the inflammatory response. Primary goal in the treatment of pneumonia is starting adequate antibiotic therapy as soon as possible. However, antimicrobial resistance among the most common bacteria causing pneumonia is increasing. For those two reasons, extended inflammatory response and increasing antibiotic resistance, it is interesting to look at adjunctive non-antibiotic therapeutic strategies aimed at modulation of the inflammatory response or at the micro-organism itself. In this review, we discuss the current knowledge... The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4494978 Sat, 01 Jan 2011 00:00:00 +0100 4494978 http://www.medworm.com/index.php?rid=4494972&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21325698%26dopt%3DAbstract Conclusion. The mildly elevated risk of arterial cardiovascular complications in patients with prior VTE appears to be independent of cardiovascular risk factors and thrombophilic defects. PMID: 21325698 [PubMed - in process] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4494972 Sat, 01 Jan 2011 00:00:00 +0100 4494972 http://www.medworm.com/index.php?rid=4494966&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21325699%26dopt%3DAbstract Authors: Postema PG, Legemate DA, Baeten DL, Speelman P A patient with Streptococcus pneumoniae aortitis is presented. Because of nonspecific symptoms (fever and back pain) there was a long diagnostic delay. In addition, the aortitis was located near the renal arteries which severely hampered early surgical treatment. Although emergency surgery was performed when aortic rupture occurred, the patient did not survive. Infectious arteritis of large vessels is a diagnosis often made late and associated with high mortality. PMID: 21325699 [PubMed - in process] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4494966 Sat, 01 Jan 2011 00:00:00 +0100 4494966 http://www.medworm.com/index.php?rid=4494960&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21325700%26dopt%3DAbstract Authors: Vendeloo M, Aarnoudse AL, van Bommel EF A 56-year-old woman developed acute respiratory failure requiring mechanical ventilation due to acute hypokalaemic paralysis. There was no gastrointestinal potassium loss nor was she taking diuretics. Additional analyses revealed a normal anion gap metabolic acidosis with a positive urine anion gap. An acid-load test revealed a renal urine acidification defect, leading to the diagnosis of distal renal tubular acidosis. Normalisation of serum potassium level was established with oral bicarbonate suppletion and temporary potassium suppletion. PMID: 21325700 [PubMed - in process] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4494960 Sat, 01 Jan 2011 00:00:00 +0100 4494960 http://www.medworm.com/index.php?rid=4494953&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21325701%26dopt%3DAbstract Authors: Gamal WL, Abdel Khalek MS, Crawford BE, Kandil EH No abstract available. PMID: 21325701 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4494953 Sat, 01 Jan 2011 00:00:00 +0100 4494953 http://www.medworm.com/index.php?rid=4494945&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21325702%26dopt%3DAbstract Authors: Moonen LA, van den Bosch H, Demeyere TB, Bravenboer B No abstract available. PMID: 21325702 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4494945 Sat, 01 Jan 2011 00:00:00 +0100 4494945 http://www.medworm.com/index.php?rid=4494937&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21325703%26dopt%3DAbstract Authors: Arends JE, Lambers FA, van der Meer JT, Schreij G, Richter C, Brinkman K, Hoepelman AI, Behalf Of The Netherlands Society For Aids Physicians Nvab O With a rising incidence of acute hepatitis C virus (HCV) infection in patients coinfected with the human immunodeficiency virus (HIV), there is a need for evidence-based treatment recommendations. There are no randomised trials available and published studies differ with respect to design, patient characteristics and number of patients included, making a comparison between studies difficult. However, it is critical to standardise treatment for this group of patients in order to optimise the outcome of therapy. The Dutch Society for HIV Physicians proposed to write recommendations for the treatment of acute HCV in HIV -coinfected p... The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4494937 Sat, 01 Jan 2011 00:00:00 +0100 4494937 http://www.medworm.com/index.php?rid=4494927&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21325704%26dopt%3DAbstract Authors: van der Straaten HM, van Asbeck BS PMID: 21325704 [PubMed - in process] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4494927 Sat, 01 Jan 2011 00:00:00 +0100 4494927 http://www.medworm.com/index.php?rid=4494914&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21325705%26dopt%3DAbstract Authors: Grant WB No abstract available. PMID: 21325705 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4494914 Sat, 01 Jan 2011 00:00:00 +0100 4494914 http://www.medworm.com/index.php?rid=4361759&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21209462%26dopt%3DAbstract Authors: Speelman P No abstract available. PMID: 21209462 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4361759 Wed, 01 Dec 2010 00:00:00 +0100 4361759 http://www.medworm.com/index.php?rid=4361758&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21209463%26dopt%3DAbstract Authors: Delsing CE, Kullberg BJ, Bleeker-Rovers CP Since 2007, the Netherlands is faced with the largest outbreak of Q fever ever reported. In the last four years, over 4000 cases have been reported. The course of the epidemic and possible factors associated with this sudden surge in cases of Q fever is described and the preventive measures in the veterinary sector and the outbreak management of this unique epidemic are summarised. Finally, the latest data on clinical presentation and diagnostic and therapeutic dilemmas of Q fever in the Netherlands are reviewed. PMID: 21209463 [PubMed - in process] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4361758 Wed, 01 Dec 2010 00:00:00 +0100 4361758 http://www.medworm.com/index.php?rid=4361757&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21209464%26dopt%3DAbstract Authors: Holewijn S, den Heijer M, Stalenhoef AF, de Graaf J In clinical practice, cardiovascular (CV) risk stratification is based on the assessment of individual risk factors. Still many cardiovascular deaths occur in individuals who were not at high risk according to the current CV risk stratification models as the Systematic COronary Risk Evaluation chart (SCORE) and Framingham Risk Score. By measuring morphological and÷or functional abnormalities in the arterial wall directly, the impact of all CV risk factors together can be determined. In this review, the current status for the use of a panel of non-invasive measurements of atherosclerosis (NIMA) in CV risk prediction in clinical practice is discussed. Some of these NIMA showed predictive value for CV disease, such as intima-me... The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4361757 Wed, 01 Dec 2010 00:00:00 +0100 4361757 http://www.medworm.com/index.php?rid=4361756&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21209465%26dopt%3DAbstract Authors: Vogt L, Laverman GD, Navis G Before the introduction of renin-angiotensin-aldosterone system (RAAS) inhibitors in the 1980s, non-steroidal anti-inflammatory drugs (NSAIDs) were the only class of drugs available for the reduction of symptomatic proteinuria. Long-term data from those days suggested sustained renoprotective properties in proteinuric chronic kidney disease (CKD), but this potential has not been further explored, due to the adverse effects of NSAIDs, and due to the successful introduction of RAAS blockade for blood pressure control and renoprotection. The renoprotective potential of NSAIDs may seem surprising for the present generation of clinicians, as NSAIDs are well known for their adverse effects on the kidney. Interestingly, the newer selective COX-2 inhibitor... The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4361756 Wed, 01 Dec 2010 00:00:00 +0100 4361756 http://www.medworm.com/index.php?rid=4361755&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21209466%26dopt%3DAbstract Conclusion: The mortality rate of patients hospitalised because of acute Q fever was estimated at approximately 1%. Patients who died with acute Q fever were often male, of older age, and had chronic coinciding underlying conditions, which gives an a priori higher risk of death. PMID: 21209466 [PubMed - in process] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4361755 Wed, 01 Dec 2010 00:00:00 +0100 4361755 http://www.medworm.com/index.php?rid=4361754&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21209467%26dopt%3DAbstract We present the case of a patient with the rare triad of Von Recklinghausen's disease associated with a somatostatinoma and a gastrointestinal stromal tumour (GIST). The patient had recurrent jaundice, the typical somatostatinoma syndrome, positive MR imaging but negative 68Ga-DOTATOC PET scanning in a histopathology-proven somatostatinoma tumour. PMID: 21209467 [PubMed - in process] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4361754 Wed, 01 Dec 2010 00:00:00 +0100 4361754 http://www.medworm.com/index.php?rid=4361753&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21209468%26dopt%3DAbstract We describe a case of haemophagocytic syndrome caused by Histoplasma capsulatum reactivation in a patient with chronic lymphocytic leukaemia treated with fludarabine and alemtuzumab. He presented with fever, pancytopenia, increased serum ferritin, lactate dehydrogenase and soluble interleukin-2 receptor. A bone marrow aspirate showed haemophagocytosis and possibly a yeast infection. Treatment with cyclosporine, dexamethasone, etoposide and caspofungin was started. After initial improvement his condition deteriorated. A second bone marrow examination confirmed a Histoplasma infection. After treatment with amphotericin B, the fever resolved and blood counts normalised. Haemophagocytic syndrome is a critical condition with high mortality that requires immunosuppressive therapy. The underlying... The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4361753 Wed, 01 Dec 2010 00:00:00 +0100 4361753 http://www.medworm.com/index.php?rid=4361752&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21209469%26dopt%3DAbstract Authors: Volman MN, Schoch AG, Storm van Leeuwen RP, Tukkie R No abstract available. PMID: 21209469 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4361752 Wed, 01 Dec 2010 00:00:00 +0100 4361752 http://www.medworm.com/index.php?rid=4361751&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21209470%26dopt%3DAbstract Authors: Renckens R, van der Valk M No abstract available. PMID: 21209470 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4361751 Wed, 01 Dec 2010 00:00:00 +0100 4361751 http://www.medworm.com/index.php?rid=4361750&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21209471%26dopt%3DAbstract Authors: Abdel Khalek MS, Gamal W, Crawford BE, Kandil EH No abstract available. PMID: 21209471 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4361750 Wed, 01 Dec 2010 00:00:00 +0100 4361750 http://www.medworm.com/index.php?rid=4361749&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21209472%26dopt%3DAbstract Authors: Dubelaar IJ, Vissers E, Serafino G No abstract available. PMID: 21209472 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4361749 Wed, 01 Dec 2010 00:00:00 +0100 4361749 http://www.medworm.com/index.php?rid=4361748&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21209473%26dopt%3DAbstract Authors: van Jaarsveld BC, van der Graaf Y, Vos PF, Soedamah-Muthu SS, Behalf Of The Smart Study Group O Background: Long-term exposure to hypercalcaemia and hyperphosphataemia leads to media calcification and predicts mortality in patients with end-stage renal disease (ESRD). It is debatable whether this exposure is only a risk factor for arteriosclerosis, or also for superimposed atherosclerosis. Calcium-phosphate exposure is difficult to quantify, because it is variable in time and exerts its deleterious effects only after prolonged presence. Methods: In 90 dialysis patients, calcium and phosphate values from the complete dialysis period were collected. From three-month averages, measures for calcium-phosphate exposure were derived after exclusion of transplant periods. Calcium-phos... The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4361748 Wed, 01 Dec 2010 00:00:00 +0100 4361748 http://www.medworm.com/index.php?rid=4361747&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21209474%26dopt%3DAbstract Authors: Hoorn EJ, Zietse R No abstract available. PMID: 21209474 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4361747 Wed, 01 Dec 2010 00:00:00 +0100 4361747 http://www.medworm.com/index.php?rid=4287880&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21158008%26dopt%3DAbstract Authors: Radić M, Martinović Kaliterna D, Radić J Systemic sclerosis is an autoimmune disease characterised by vascular obliteration, excessive extracellular matrix deposition and fibrosis of the connective tissues of the skin, lungs, gastrointestinal tract, heart, and kidneys. The pathogenesis of systemic sclerosis is extremely complex; at present, no single unifying hypothesis explains all aspects. Over the last 20 years increasing evidence has accumulated to implicate infectious agents in the aetiology of systemic sclerosis. Increased antibody titres, a preponderance of specific strains in patients with systemic sclerosis, and evidence of molecular mimicry inducing autoimmune responses suggest mechanisms by which infectious agents may contribute to the development and progression... The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4287880 Mon, 01 Nov 2010 00:00:00 +0100 4287880 http://www.medworm.com/index.php?rid=4230890&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21116025%26dopt%3DAbstract Authors: Levi M No abstract available. PMID: 21116025 [PubMed - as supplied by publisher] (Source: The Netherlands Journal of Medicine) The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4230890 Mon, 01 Nov 2010 00:00:00 +0100 4230890 http://www.medworm.com/index.php?rid=4230889&cid=s_36793_22_f&fid=36793&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21116026%26dopt%3DAbstract Authors: Seger RA Chronic granulomatous disease (CGD) was characterised half a century ago as a primary immunodeficiency disorder of phagocytic cells resulting in failure to kill a specific spectrum of bacteria and fungi and in concomitant hyperinflammation with widespread tissue granuloma formation. CGD now comprises five genetic defects, each impairing one of five essential subunits of the phagocyte NADPH oxidase generating reactive oxygen species. In the past few years CGD has lead to a new understanding of the importance of phagocyte oxygen metabolism for intra- and extracellular host defence and for resolution of the concomitant inflammatory process. In a not too distant future, this may help to tailor novel pharmacological and cellular interventions to the requirements of individ... The Netherlands Journal of Medicine journals http://www.medworm.com/rss/comments.php?id=4230889 Mon, 01 Nov 2010 00:00:00 +0100 4230889