MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'The Ocular Surface' source. Mon, 28 Nov 2011 12:08:07 +0100 http://www.medworm.com/index.php?rid=5353721&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22023813%26dopt%3DAbstract Authors: Foulks GN PMID: 22023813 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=5353721 Sat, 01 Oct 2011 04:00:00 +0100 5353721 http://www.medworm.com/index.php?rid=5353720&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22023814%26dopt%3DAbstract Authors: Murube J PMID: 22023814 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=5353720 Sat, 01 Oct 2011 04:00:00 +0100 5353720 http://www.medworm.com/index.php?rid=5353719&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22023815%26dopt%3DAbstract Authors: King-Smith PE, Nichols JJ, Braun RJ, Nichols KK Abstract ABSTRACT Tear film evaporation is controlled by the lipid layer and is an important factor in dry eye conditions. Because the barrier to evaporation depends on the structure of the lipid layer, a high resolution microscope has been constructed to study the lipid layer in dry and in normal eyes. The microscope incorporates the following features. First, a long working distance microscope objective is used with a high numerical aperture and resolution. Second, because such a high resolution objective has limited depth of focus, 2000 images are recorded with a video camera over a 20-sec period, with the expectation that some images will be in focus. Third, illumination is from a stroboscopic light source having a brief ... The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=5353719 Sat, 01 Oct 2011 04:00:00 +0100 5353719 http://www.medworm.com/index.php?rid=5353718&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22023816%26dopt%3DAbstract Authors: Wong J, Lan W, Ong LM, Tong L Abstract ABSTRACT Many drugs used for chronic illnesses can contribute to dry eye syndrome, and elderly patients who have dry eye may concurrently be on systemic medications that worsen the condition. Such medications include anticholinergic drugs, eg, antidepressant, antipsychotic, anti-Parkinson's disease, and antihistamine drugs. Other drugs such as anti-acne preparations and antihypertensives can also cause dry eye. In some cases, the adverse effects of the drug on dry eye is dose-related and can be relieved by reducing the dosage. Alternatively, a different drug within the same drug family may alleviate the dry eye problem. Awareness of the drugs that contribute to dry eye will allow ophthalmologists and other physicians to better manage ... The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=5353718 Sat, 01 Oct 2011 04:00:00 +0100 5353718 http://www.medworm.com/index.php?rid=5353717&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22023817%26dopt%3DAbstract Authors: Keating AM, Jacobs DS Abstract ABSTRACT Vascular endothelial growth factor (VEGF) is an angiogenic factor shown to be a critical secreted cytokine in tumorigenesis and retinal neovascularization (NV). Currently, there are two anti-VEGF agents, pegaptanib and ranizumab, approved by the United States Food and Drug Administration (FDA) for intravitreal use in the treatment of wet age-related macular degeneration (AMD). Bevacizumab is FDA-approved for intravenous administration in the treatment of several cancers and is in widespread use, off-label, as an intravitreal injection to treat a variety of retinal pathologies. Animal studies demonstrate the role of VEGF in corneal NV. There are now a number of human case series reporting the use of anti-VEGF agents, primarily bevaciz... The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=5353717 Sat, 01 Oct 2011 04:00:00 +0100 5353717 http://www.medworm.com/index.php?rid=5353716&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22023818%26dopt%3DAbstract Authors: Novack GD PMID: 22023818 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=5353716 Sat, 01 Oct 2011 04:00:00 +0100 5353716 http://www.medworm.com/index.php?rid=5353715&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22023819%26dopt%3DAbstract Authors: Jones L PMID: 22023819 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=5353715 Sat, 01 Oct 2011 04:00:00 +0100 5353715 http://www.medworm.com/index.php?rid=5078269&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21791185%26dopt%3DAbstract Authors: Foulks GN PMID: 21791185 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=5078269 Thu, 30 Jun 2011 23:00:00 +0100 5078269 http://www.medworm.com/index.php?rid=5078268&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21791186%26dopt%3DAbstract Authors: Murube J PMID: 21791186 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=5078268 Thu, 30 Jun 2011 23:00:00 +0100 5078268 http://www.medworm.com/index.php?rid=5078267&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21791187%26dopt%3DAbstract Authors: Dartt DA ABSTRACT Lipocalins are a family of diverse low molecular weight proteins that act extracellularly. They use multiple recognition properties that include 1) ligand binding to small hydrophobic molecules, 2) macromolecular complexation with other soluble macromolecules, and 3) binding to specific cell surface receptors to deliver cargo. Tear lipocalin (TLC) is a major protein in tears and has a large ligand-binding cavity that allows the lipocalin to bind an extensive and diverse set of lipophilic molecules. TLC can also bind to macromolecules, including the tear proteins lactoferin and lysozyme. The receptor to which TLC binds is termed tear lipocalin-interacting membrane receptor (LIMR). LIMR appears to work by endocytosis. TLC has a variety of suggested functions in... The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=5078267 Thu, 30 Jun 2011 23:00:00 +0100 5078267 http://www.medworm.com/index.php?rid=5078266&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21791188%26dopt%3DAbstract Authors: Foulks GN PMID: 21791188 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=5078266 Thu, 30 Jun 2011 23:00:00 +0100 5078266 http://www.medworm.com/index.php?rid=5078265&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21791189%26dopt%3DAbstract Authors: Tressler CS, Beatty R, Lemp MA ABSTRACT Benzalkonium chloride (BAK) is the principal preservative employed in topical ocular hypotensive medications, although alternative compounds recently have begun to be employed or examined. Individual clinical trials have shown that exposure to BAK concentrations contained in ophthalmic solutions does not produce adverse sequelae in the majority of glaucoma patients, but concerns continue with regard to its long-term use. These concerns have resulted from an extensive research effort, including preclinical studies with in vitro and in vivo models, as well as recent clinical investigations dedicated specifically to this issue. The aim of this systematic literature review of both preclinical and clinical data was to determine the relevance ... The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=5078265 Thu, 30 Jun 2011 23:00:00 +0100 5078265 http://www.medworm.com/index.php?rid=5078264&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21791190%26dopt%3DAbstract Authors: Noecker R, Miller KV ABSTRACT Benzalkonium chloride (BAK) is the preservative used most commonly in eye drops. Although it is effective as an antimicrobial and antifungal agent, both in vitro and in vivo studies have demonstrated adverse effects on surface epithelial cell populations. This is of particular concern with regard to topical medications used over long periods for chronic conditions, such as glaucoma. Newer non-BAK-containing drops are becoming increasingly available, providing an alternative for patients needing long-term eye drop therapy. PMID: 21791190 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=5078264 Thu, 30 Jun 2011 23:00:00 +0100 5078264 http://www.medworm.com/index.php?rid=5078263&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21791191%26dopt%3DAbstract Authors: Baradaran-Rafii A, Eslani M, Tseng SC ABSTRACT Sulfur mustard is a vesicant agent with severe irritating effects on living tissues, including skin, mucous membranes, eyes, and respiratory tract. The eyes are the most susceptible tissue to mustard gas effects, and varying degrees of ocular involvement are seen in 75% to 90% of exposed individuals. Most cases resolve uneventfully; however, a minority of exposed patients will have a continuous process, which manifests clinically either as a persistent smoldering inflammation (chronic form) or late-onset lesions appearing many years after a variable "silent" period (delayed form). Distinctive features common to most cases with chronic involvement include chronic blepharitis, meibomian gland dysfunction, dry eye, limbal ischemia, l... The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=5078263 Thu, 30 Jun 2011 23:00:00 +0100 5078263 http://www.medworm.com/index.php?rid=5078262&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21791192%26dopt%3DAbstract Authors: PMID: 21791192 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=5078262 Thu, 30 Jun 2011 23:00:00 +0100 5078262 http://www.medworm.com/index.php?rid=5078261&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21791193%26dopt%3DAbstract Authors: Novack GD PMID: 21791193 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=5078261 Thu, 30 Jun 2011 23:00:00 +0100 5078261 http://www.medworm.com/index.php?rid=4832972&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21545759%26dopt%3DAbstract Authors: Foulks GN PMID: 21545759 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=4832972 Thu, 31 Mar 2011 23:00:00 +0100 4832972 http://www.medworm.com/index.php?rid=4832971&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21545760%26dopt%3DAbstract Authors: Murube J PMID: 21545760 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=4832971 Thu, 31 Mar 2011 23:00:00 +0100 4832971 http://www.medworm.com/index.php?rid=4832970&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21545761%26dopt%3DAbstract Authors: Bron AJ, Yokoi N, Gaffney EA, Tiffany JM Marx's line is a line of mucosal staining behind the mucocutaneous junction. It can be demonstrated throughout life in all normal lids by staining with lissamine green and related dyes. Of all the body orifices, only the mucosae of the eye and mouth are directly exposed to the atmosphere. In this paper, we suggest that for the eye, this exposure leads to the formation of Marx's line. The tear meniscus thins progressively toward its apex, where it is pinned at the mucocutaneous junction of the lid. It also thins toward the black line, which segregates the meniscus from the tear film after the blink. We predict that, because of the geometry of the tear meniscus, evaporation generates a solute gradient across the meniscus profile in the an... The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=4832970 Thu, 31 Mar 2011 23:00:00 +0100 4832970 http://www.medworm.com/index.php?rid=4832969&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21545762%26dopt%3DAbstract Authors: Bron AJ, Yokoi N, Gaffney EA, Tiffany JM We have hypothesized previously that evaporation from the tears generates a solute gradient across the tear meniscus, which delivers hyperosmolar stress to the mucocutaneous junction (MCJ) of the lid margin. This is proposed as the basis for Marx's line, a line of staining with topically applied dyes that lies directly behind the MCJ. In this article, we consider the implications of this hypothesis for progressive damage to the lid margin as an age-related phenomenon, its amplification in dry eye states, and its possible role in the etiology of meibomian gland dysfunction (MGD). It is suggested that a hyperosmolar or related stimulus, acting behind the MCJ over a lifetime, promotes the anterior migration of the MCJ, which is a feature o... The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=4832969 Thu, 31 Mar 2011 23:00:00 +0100 4832969 http://www.medworm.com/index.php?rid=4832968&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21545763%26dopt%3DAbstract Authors: Luengo-Gimeno F, Tan DT, Mehta JS The concept of selective tissue transplantation was theorized over two centuries ago. However, deep anterior lamellar keratoplasty (DALK) was difficult to perform with the instruments available at that time, and visual acuity results were poor compared to those achieved by full-thickness transplantation. Recently, many technical improvements in surgical instrumentation and advances in eye bank technology have led to the re-emergence of DALK. Now, patients with stromal pathologies not affecting the corneal endothelium can benefit from this surgery, which allows total stromal replacement of the recipient's cornea, leaving an intact recipient Descemet membrane and endothelium. Along with the advances in surgical instrumentation, improvements in s... The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=4832968 Thu, 31 Mar 2011 23:00:00 +0100 4832968 http://www.medworm.com/index.php?rid=4832967&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21545764%26dopt%3DAbstract Authors: Novack GD PMID: 21545764 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=4832967 Thu, 31 Mar 2011 23:00:00 +0100 4832967 http://www.medworm.com/index.php?rid=4554401&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21338562%26dopt%3DAbstract Authors: Foulks GN PMID: 21338562 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=4554401 Sat, 01 Jan 2011 00:00:00 +0100 4554401 http://www.medworm.com/index.php?rid=4554400&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21338564%26dopt%3DAbstract Authors: Dieckow J PMID: 21338564 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=4554400 Sat, 01 Jan 2011 00:00:00 +0100 4554400 http://www.medworm.com/index.php?rid=4554399&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21338565%26dopt%3DAbstract Authors: Murube J PMID: 21338565 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=4554399 Sat, 01 Jan 2011 00:00:00 +0100 4554399 http://www.medworm.com/index.php?rid=4554398&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21338566%26dopt%3DAbstract Authors: Pritchard N, Edwards K, Shahidi AM, Sampson GP, Russell AW, Malik RA, Efron N Diabetic neuropathy is a significant clinical problem that currently has no effective therapy, and in advanced cases, leads to foot ulceration and lower limb amputation. The accurate detection, characterization and quantification of this condition are important in order to define at-risk patients, anticipate deterioration, monitor progression, and assess new therapies. This review evaluates novel corneal methods of assessing diabetic neuropathy. Two new noninvasive corneal markers have emerged, and in cross-sectional studies have demonstrated their ability to stratify the severity of this disease. Corneal confocal microscopy allows quantification of corneal nerve parameters and noncontact corneal est... The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=4554398 Sat, 01 Jan 2011 00:00:00 +0100 4554398 http://www.medworm.com/index.php?rid=4554397&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21338567%26dopt%3DAbstract Authors: Cruz AA, Garcia DM, Pinto CT, Cechetti SP Spontaneous blinking is essential for maintaining a healthy ocular surface and clarity of vision. The spontaneous blink rate (SBR) is believed to reflect a complex interaction between peripheral influences mediated by the eye surface and the central dopaminergic activity. The SBR is thus extremely variable and dependent on a variety of psychological and medical conditions. Many different methods have been employed to measure the SBR and the upper eyelid kinematics during a blink movement. Each has its own merits and drawbacks, and the choice of a specific method should be tailored to the specific needs of the investigation. Although the sequence of muscle events that leads to a blink has been fully described, knowledge about the neural... The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=4554397 Sat, 01 Jan 2011 00:00:00 +0100 4554397 http://www.medworm.com/index.php?rid=4554396&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21338568%26dopt%3DAbstract Authors: Ridder WH, Tomlinson A, Huang JF, Li J Patients with dry eye disease (DED) often complain about poor vision, which is not easily quantifiable. This review assesses the current understanding of clinical evaluations of visual function in patients with DED. Several noninvasive techniques for the assessment of visual performance have been utilized in patients with DED, and these are critically reviewed in relation to the visual symptoms experienced by these patients. It is clear that none of the current techniques is ideal, and there is not one appropriate, simple, clinical test that can be used for assessing visual impairment in patients with DED. Evidence from a comprehensive literature search combined with clinical experience have been used to identify which tests are currently... The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=4554396 Sat, 01 Jan 2011 00:00:00 +0100 4554396 http://www.medworm.com/index.php?rid=4554395&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21338569%26dopt%3DAbstract Authors: Novack GD PMID: 21338569 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=4554395 Sat, 01 Jan 2011 00:00:00 +0100 4554395 http://www.medworm.com/index.php?rid=4100555&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20964978%26dopt%3DAbstract Authors: Foulks GN PMID: 20964978 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=4100555 Thu, 30 Sep 2010 23:00:00 +0100 4100555 http://www.medworm.com/index.php?rid=4100554&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20964979%26dopt%3DAbstract Authors: Murube J PMID: 20964979 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=4100554 Thu, 30 Sep 2010 23:00:00 +0100 4100554 http://www.medworm.com/index.php?rid=4100553&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20964980%26dopt%3DAbstract Authors: Elhalis H, Azizi B, Jurkunas UV ABSTRACT Fuchs endothelial corneal dystrophy (FECD) is characterized by progressive loss of corneal endothelial cells, thickening of Descement's membrane and deposition of extracellular matrix in the form of guttae. When the number of endothelial cells becomes critically low, the cornea swells and causes loss of vision. The clinical course of FECD usually spans 10-20 years. Corneal transplantation is currently the only modality used to restore vision. Over the last several decades genetic studies have detected several genes, as well as areas of chromosomal loci associated with the disease. Proteomic studies have given rise to several hypotheses regarding the pathogenesis of FECD. This review expands upon the recent findings from proteomic and ge... The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=4100553 Thu, 30 Sep 2010 23:00:00 +0100 4100553 http://www.medworm.com/index.php?rid=4100552&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20964981%26dopt%3DAbstract Authors: Montés-Micó R, Cerviño A, Ferrer-Blasco T, García-Lázaro S, Madrid-Costa D ABSTRACT The stability of the tear film plays an important role in the optical quality of the eye. Various methods have been developed to quantify the contribution of the tear film to optical quality, including the double-pass optical method, Hartmann-Shack wavefront sensing, videokeratoscopy, retroillumination analysis, and interferometry. In addition to assessing the effect of tear film irregularities, these methods can aid in the diagnosis of dry-eye related conditions and the monitoring of therapy. This review describes the methodologies used to assess the relationship between the tear film and optical quality of the eye and summarizes the most important findings obtained with these methods wit... The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=4100552 Thu, 30 Sep 2010 23:00:00 +0100 4100552 http://www.medworm.com/index.php?rid=4100551&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20964982%26dopt%3DAbstract Authors: Fu Y, Gregory DG, Sippel KC, Bouchard CS, Tseng SC ABSTRACT Stevens-Johnson syndrome (SJS) and its more severe variant, toxic epidermal necrolysis (TEN), are relatively rare but have high mortality rates. Survivors are frequently afflicted with severe blinding ocular surface diseases. Recent literature in the areas of ophthalmology and dermatology illustrate that the ophthalmologist's role should no longer be considered secondary in the acute management of SJS/TEN. Accurately differentiating SJS or TEN from erythema multiforme majus (EMM) at the onset of the disease is important, because the management approach to these disease entities differs. Systemic cyclosporine and intravenous immunoglobulin have shown some potential as treatments for SJS/TEN, but their efficacies remain... The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=4100551 Thu, 30 Sep 2010 23:00:00 +0100 4100551 http://www.medworm.com/index.php?rid=4100550&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20964983%26dopt%3DAbstract Authors: Novack GD PMID: 20964983 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=4100550 Thu, 30 Sep 2010 23:00:00 +0100 4100550 http://www.medworm.com/index.php?rid=4100549&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20964984%26dopt%3DAbstract Authors: McCulley JP PMID: 20964984 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=4100549 Thu, 30 Sep 2010 23:00:00 +0100 4100549 http://www.medworm.com/index.php?rid=3877584&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20712967%26dopt%3DAbstract Authors: Foulks GN PMID: 20712967 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=3877584 Wed, 30 Jun 2010 23:00:00 +0100 3877584 http://www.medworm.com/index.php?rid=3877583&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20712968%26dopt%3DAbstract Authors: Murube J PMID: 20712968 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=3877583 Wed, 30 Jun 2010 23:00:00 +0100 3877583 http://www.medworm.com/index.php?rid=3877582&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20712969%26dopt%3DAbstract Authors: Schechter JE, Warren DW, Mircheff AK ABSTRACT Research into the physiological processes governing both normal and abnormal functions of the lacrimal gland has used animal models to provide insights that might be applied to improving our understanding of human disease and designing of beneficial therapeutic interventions. Animal models most frequently used are mice, rats, and rabbits. As participants in research into normal and abnormal lacrimal gland function, the authors have observed significant differences between the various animal models, and these differences must be considered in investigational studies. This review summarizes a wide range of topics, including structural organization of the lacrimal gland and the immunological, secretomotor and hormonal processes regula... The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=3877582 Wed, 30 Jun 2010 23:00:00 +0100 3877582 http://www.medworm.com/index.php?rid=3877581&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20712970%26dopt%3DAbstract Authors: Nettune GR, Pflugfelder SC ABSTRACT Symptoms of tear dysfunction after laser in situ keratomileusis (LASIK) occur in nearly all patients and resolve in the vast majority. Although dry eye complaints are a leading cause of patient discomfort and dissatisfaction after LASIK, the symptoms are not uniform, and the disease is not a single entity. Post-LASIK tear dysfunction syndrome or dry eye is a term used to describe a spectrum of disease encompassing transient or persistent post-operative neurotrophic disease, tear instability, true aqueous tear deficiency, and neuropathic pain states. Neural changes in the cornea and neuropathic causes of ocular surface discomfort may play a separate or synergistic role in the development of symptoms in some patients. Most cases of early post-... The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=3877581 Wed, 30 Jun 2010 23:00:00 +0100 3877581 http://www.medworm.com/index.php?rid=3877580&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20712971%26dopt%3DAbstract Authors: Iorio ED, Ferrari S, Fasolo A, Böhm E, Ponzin D, Barbaro V ABSTRACT The therapeutic use of limbal cultures for the permanent regeneration of corneal epithelium in patients with limbal stem cell deficiency (LSCD) has been reported in many studies. According to the guidelines for good manufacturing practice (GMP), strictly regulated procedures and stringent quality control tests are now required to manipulate stem cells as "medicinal products" and make engraftment safer and eventually more successful. This paper describes techniques for optimal preparation of limbal stem cell grafts, including 1) a reliable impression cytology assay for the grading of LSCD, 2) culture methods that maintain high percentages of limbal stem cells, 3) the use of specific markers for the detection... The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=3877580 Wed, 30 Jun 2010 23:00:00 +0100 3877580 http://www.medworm.com/index.php?rid=3877579&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20712972%26dopt%3DAbstract Authors: Abelson MB PMID: 20712972 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=3877579 Wed, 30 Jun 2010 23:00:00 +0100 3877579 http://www.medworm.com/index.php?rid=3877578&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20712973%26dopt%3DAbstract Authors: Novack GD PMID: 20712973 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=3877578 Wed, 30 Jun 2010 23:00:00 +0100 3877578 http://www.medworm.com/index.php?rid=3519860&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20427007%26dopt%3DAbstract Authors: Foulks GN PMID: 20427007 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=3519860 Wed, 31 Mar 2010 23:00:00 +0100 3519860 http://www.medworm.com/index.php?rid=3519859&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20427008%26dopt%3DAbstract Authors: Murube J PMID: 20427008 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=3519859 Wed, 31 Mar 2010 23:00:00 +0100 3519859 http://www.medworm.com/index.php?rid=3519858&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20427009%26dopt%3DAbstract This article reviews recent advances in exocrine tissue injury and repair, with emphasis on the roles of programmed cell death and stem/progenitor cells. PMID: 20427009 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=3519858 Wed, 31 Mar 2010 23:00:00 +0100 3519858 http://www.medworm.com/index.php?rid=3519857&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20427010%26dopt%3DAbstract Authors: Panjwani N ABSTRACT Acanthamoeba keratitis (AK) is a serious infection of the cornea. At present, diagnosis of the disease is not straightforward and treatment is very demanding. While contact lens wear is the leading risk factor for A K, Acanthamoeba parasites are increasingly recognized as an important cause of keratitis in non-contact lens wearers. The first critical step in the pathogenesis of infection is the adhesion of the microbe to the surface of the host tissues. Acanthamoebae express a major virulence protein, the mannose-binding protein (MBP), which mediates the adhesion of amoebae to the surface of the cornea. The MBP is a transmembrane protein with characteristics of a typical cell surface receptor. Subsequent to the MBP-mediated adhesion to host cells, the amoeb... The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=3519857 Wed, 31 Mar 2010 23:00:00 +0100 3519857 http://www.medworm.com/index.php?rid=3519856&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20427011%26dopt%3DAbstract Authors: Shortt AJ, Tuft SJ, Daniels JT ABSTRACT The term ex vivo cultured limbal epithelial transplantation (CLET) refers to the process of culturing a sheet of human limbal epithelium in the laboratory and transplanting this sheet back onto the limbal stem cell-deficient cornea of the same patient or another recipient. This emerging technology represents one of the earliest successes in regenerative medicine. CLET is, at present, best suited to patients who have unilateral total limbal stem cell deficiency arising from chemical injury and who are suitable for autologous cell culture and transplantation. Although the results of allogeneic cell transplantation are encouraging and superior to conventional stem cell transplantation techniques, insufficient follow-up precludes conclusions... The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=3519856 Wed, 31 Mar 2010 23:00:00 +0100 3519856 http://www.medworm.com/index.php?rid=3519855&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20427012%26dopt%3DAbstract Authors: Novack GD PMID: 20427012 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=3519855 Wed, 31 Mar 2010 23:00:00 +0100 3519855 http://www.medworm.com/index.php?rid=3519854&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20427013%26dopt%3DAbstract Authors: Nelson JD PMID: 20427013 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=3519854 Wed, 31 Mar 2010 23:00:00 +0100 3519854 http://www.medworm.com/index.php?rid=3223608&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20105401%26dopt%3DAbstract Authors: Foulks GN PMID: 20105401 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=3223608 Fri, 01 Jan 2010 00:00:00 +0100 3223608 http://www.medworm.com/index.php?rid=3223607&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20105402%26dopt%3DAbstract Henrik sjögren, 1899-1986. Ocul Surf. 2010 Jan;8(1):2-7 Authors: Murube J PMID: 20105402 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=3223607 Fri, 01 Jan 2010 00:00:00 +0100 3223607 http://www.medworm.com/index.php?rid=3223606&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20105403%26dopt%3DAbstract Authors: Guzman-Aranguez A, Argüeso P ABSTRACT Mucins are major components in mucus secretions and apical cell membranes on wet-surfaced epithelia. Structurally, they are characterized by the presence of tandem repeat domains containing heavily O-glycosylated serine and threonine residues. O-glycans contribute to maintaining the highly extended and rigid structure of mucins, conferring to them specific physical and biological properties essential for their protective functions. at the ocular surface epithelia, mucin-type O-glycan chains are short and predominantly sialylated, perhaps reflecting specific requirements of the ocular surface. Traditionally, secreted mucins and their O-glycans in the tear film have been involved in the clearance of debris and pathogens from the surface... The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=3223606 Fri, 01 Jan 2010 00:00:00 +0100 3223606 http://www.medworm.com/index.php?rid=3223605&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20105404%26dopt%3DAbstract This article provides an overview of the current literature regarding EFAs and dry eye disease (DED). Eight studies were identified, including six randomized controlled trials. All the studies preliminarily confirmed that there is a relationship between EFA supplementation and improvement in DED. However, strong conclusions cannot be made yet because of limitations in the research reported. The role of essential fatty acids is an important topic that would benefit from a large, multicenter, randomized clinical trial powered to reach a conclusion regarding the efficacy of essential fatty acids in the treatment of dry eye disease. PMID: 20105404 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=3223605 Fri, 01 Jan 2010 00:00:00 +0100 3223605 http://www.medworm.com/index.php?rid=3223604&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20105405%26dopt%3DAbstract Authors: Sokol JA, Foulks GN, Haider A, Nunery WR ABSTRACT The orbital manifestations of ophthalmic Graves' disease have been appreciated since the first description of the disease many years ago. The effects of ophthalmic Graves' disease on the ocular surface, although some of the most bothersome and potentially damaging features of the disease, are often not as well appreciated. This review identifies and summarizes the manifestations of ocular surface disease attendant to ophthalmic Graves' disease and provides recommendations for clinical evaluation and management options to control the ocular surface problems. PMID: 20105405 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=3223604 Fri, 01 Jan 2010 00:00:00 +0100 3223604 http://www.medworm.com/index.php?rid=3223603&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20105406%26dopt%3DAbstract Authors: Novack GD PMID: 20105406 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=3223603 Fri, 01 Jan 2010 00:00:00 +0100 3223603 http://www.medworm.com/index.php?rid=3223602&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20105407%26dopt%3DAbstract Authors: Kinoshita S PMID: 20105407 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=3223602 Fri, 01 Jan 2010 00:00:00 +0100 3223602 http://www.medworm.com/index.php?rid=3045484&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19948099%26dopt%3DAbstract Authors: Foulks GN PMID: 19948099 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=3045484 Thu, 01 Oct 2009 00:00:00 +0100 3045484 http://www.medworm.com/index.php?rid=3045483&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19948100%26dopt%3DAbstract Authors: Murube J PMID: 19948100 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=3045483 Thu, 01 Oct 2009 00:00:00 +0100 3045483 http://www.medworm.com/index.php?rid=3045482&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19948101%26dopt%3DAbstract Authors: Chen Y, Mehta G, Vasiliou V ABSTRACT The human eye is subjected constantly to oxidative stress due to daily exposure to sunlight, high metabolic activities, and oxygen tension. Reactive oxygen species generated from environmental insults and pathological conditions render the human eye particularly vulnerable to oxidative damage. The ocular surface composed of the tear film, the cornea, and the aqueous humor forms the first physical and biochemical barrier of the eye and plays a pivotal role in combating free radicals. These ocular compartments are enriched in certain antioxidants in the form of metabolic enzymes or small molecules. Such an antioxidant defense system in the ocular surface is essential for the maintenance of redox homeostasis in the eye and protection against o... The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=3045482 Thu, 01 Oct 2009 00:00:00 +0100 3045482 http://www.medworm.com/index.php?rid=3045481&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19948102%26dopt%3DAbstract Authors: Tomlinson A, Doane MG, McFadyen A ABSTRACT Meta-analyses were carried out of studies of tear production (by fluorophotometry, tear turnover rate[TTR]) and evaporation (from capture of fluid loss from the eye). TTR was reduced in dry eye relative to normal at 9.26 +/- 5.08%/min (0.54 +/- 0.28 mul/min) vs 16.19 +/- 5.1%/min (1.03 +/- 0.39 mul/min); with values of 7.71 +/- 1.02 %/min (0.4 +/- 0.10 mul/min) in aqueous deficiency dry eye (ADDE) and 11.95 +/- 4.25%/min (0.71 +/- 0.25 mul/min) in evaporative dry eye (EDE). Evaporation was increased in dry eye at 21.05 +/- 13.96 x 10(-7)g/cm(2)/s (0.21 +/- 0.13 mul/min) vs 13.57 +/- 6.52 x 10(-7)g/cm(2)/s (0.14 +/- 0.07 mul/min) in normals; with values of 17.91 +/- 10.49 x 10(-7)g/cm(2)/s (0.17 +/- 0.1 mul/min) in ADDE and 25.34 +/- 1... The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=3045481 Thu, 01 Oct 2009 00:00:00 +0100 3045481 http://www.medworm.com/index.php?rid=3045480&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19948103%26dopt%3DAbstract Authors: Johnson ME ABSTRACT There is an intuitive causal link between the signs of dry eye observed by clinicians and the severity of symptoms experienced by patients. However, this expectation is challenged by asymptomatic patients with obvious tear film anomalies and extensive ocular surface compromise and, conversely, by patients with intolerable symptoms of dryness in whom only minimal disease can be observed. Knowledge of how symptoms reflect the state of disease would enable clinicians to better understand and manage patients with apparently idiosyncratic disease presentations. This paper reviews the literature and describes the difficulties of investigating the correspondence between symptoms and signs in dry eye. The measurement of and analytical methods used to compare these ... The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=3045480 Thu, 01 Oct 2009 00:00:00 +0100 3045480 http://www.medworm.com/index.php?rid=3045479&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19948104%26dopt%3DAbstract Authors: Novack GD PMID: 19948104 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=3045479 Thu, 01 Oct 2009 00:00:00 +0100 3045479 http://www.medworm.com/index.php?rid=3045478&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19948105%26dopt%3DAbstract Authors: Lemp MA PMID: 19948105 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=3045478 Thu, 01 Oct 2009 00:00:00 +0100 3045478 http://www.medworm.com/index.php?rid=3045477&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19948106%26dopt%3DAbstract Authors: PMID: 19948106 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=3045477 Thu, 01 Oct 2009 00:00:00 +0100 3045477 http://www.medworm.com/index.php?rid=2649953&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19635244%26dopt%3DAbstract Authors: Foulks GN PMID: 19635244 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=2649953 Tue, 30 Jun 2009 23:00:00 +0100 2649953 http://www.medworm.com/index.php?rid=2649952&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19635245%26dopt%3DAbstract Authors: Murube J PMID: 19635245 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=2649952 Tue, 30 Jun 2009 23:00:00 +0100 2649952 http://www.medworm.com/index.php?rid=2649951&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19635246%26dopt%3DAbstract Authors: Ma DH, Chen HC, Lai JY, Sun CC, Wang SF, Lin KK, Chen JK ABSTRACT Corneal neovascularization (CNV) associated with severe limbal stem cell (LSC) deficiency remains a challenging ocular surface disease in that corneal inflammation may persist and progress, and the condition will not improve without LSC transplantation. A prominent feature after successful LSC transplantation is the suppression of corneal inflammation and CNV, which is generally attributed to the endogenous anti-angiogenic/anti-inflammatory factors secreted by corneal epithelial cells. In addition, corneal epithelial basement membrane (EBM) plays a unique role in the regulation of angiogenesis; several potent anti-angiogenic factors are derived from the matrix component of EBM, such as endostatin (from collagen ... The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=2649951 Tue, 30 Jun 2009 23:00:00 +0100 2649951 http://www.medworm.com/index.php?rid=2649950&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19635247%26dopt%3DAbstract Authors: Wojtowicz JC, Butovich IA, McCulley JP ABSTRACT Meibomian glands (MG) secrete an oily substance, meibum, that spreads across the ocular surface and mixes with secretions produced by other ocular structures to create a thin film. The protective efficacy of the tear film is believed to be related to the chemical composition of the lipid layer. We reviewed the literature describing the composition of human MG secretions and have provided an overview on methods of collecting meibum samples, methods of lipid analyses, and the results obtained in previous studies. The usefulness and quality of the data obtained about meibum depend on proper sampling and the analytical techniques used. Historically, several methods have been developed, which have yielded contradictory data regarding ... The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=2649950 Tue, 30 Jun 2009 23:00:00 +0100 2649950 http://www.medworm.com/index.php?rid=2649949&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19635248%26dopt%3DAbstract Authors: Wander AH, Koffler BH ABSTRACT Options for extending the duration of tear film protection in dry eyes include artificial tear formulations with enhanced viscosity/polymeric systems, ocular ointments and gels, and, recently, the hydroxypropyl cellulose ophthalmic insert (Lacrisert(R); distributed by Aton Pharma, Inc., Lawrenceville, NJ, USA). The goal in using these agents is to achieve a balance between maximizing tear film stability and ocular surface retention, while simultaneously maintaining or improving vision, comfort, and convenience. In this article, various agents are reviewed, and findings are presented from a retrospective study of patients who used hydroxypropyl cellulose ophthalmic inserts within the previous 2 years. The median length of therapy with the insert w... The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=2649949 Tue, 30 Jun 2009 23:00:00 +0100 2649949 http://www.medworm.com/index.php?rid=2649948&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19635249%26dopt%3DAbstract Authors: Novack GD, Crockett RS PMID: 19635249 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=2649948 Tue, 30 Jun 2009 23:00:00 +0100 2649948 http://www.medworm.com/index.php?rid=2649947&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19635250%26dopt%3DAbstract Authors: Novack GD PMID: 19635250 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=2649947 Tue, 30 Jun 2009 23:00:00 +0100 2649947 http://www.medworm.com/index.php?rid=2538196&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19383269%26dopt%3DAbstract Authors: Lemp MA, Nichols KK ABSTRACT Like dry eye disease 15 years ago, blepharitis today is a poorly defined condition about which there is considerable misunderstanding. For a variety of reasons, there is little good data on either the prevalence of blepharitis or how eyecare practitioners currently treat it. The work reported herein consists of two recent studies: a telephone survey of a representative sample of the adult US population (n = 5,000) whose purpose was to discover the frequency of common ocular surface symptoms associated with blepharitis; and a study that queried a selected group of ophthalmologists (n = 120) and a similarly selected group of optometrists (n = 84) about the frequency of blepharitis in their practices, the existence comorbid conditions, and their manag... The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=2538196 Tue, 31 Mar 2009 23:00:00 +0100 2538196 http://www.medworm.com/index.php?rid=2538195&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19383270%26dopt%3DAbstract Authors: Foulks GN PMID: 19383270 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=2538195 Tue, 31 Mar 2009 23:00:00 +0100 2538195 http://www.medworm.com/index.php?rid=2538194&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19383271%26dopt%3DAbstract Authors: McDonald MB PMID: 19383271 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=2538194 Tue, 31 Mar 2009 23:00:00 +0100 2538194 http://www.medworm.com/index.php?rid=2538193&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19383272%26dopt%3DAbstract Authors: Lindstrom RL PMID: 19383272 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=2538193 Tue, 31 Mar 2009 23:00:00 +0100 2538193 http://www.medworm.com/index.php?rid=2538192&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19383273%26dopt%3DAbstract Authors: Foulks GN PMID: 19383273 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=2538192 Tue, 31 Mar 2009 23:00:00 +0100 2538192 http://www.medworm.com/index.php?rid=2538191&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19383274%26dopt%3DAbstract Authors: Murube J PMID: 19383274 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=2538191 Tue, 31 Mar 2009 23:00:00 +0100 2538191 http://www.medworm.com/index.php?rid=2538190&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19383275%26dopt%3DAbstract Authors: Pflugfelder SC, Stern ME, A one-day symposium with 20 invited participants was held to review current knowledge regarding immunoregulation in the ocular surface and cornea. The program consisted of 11 lectures on various aspects of ocular and systemic immunoregulation, followed by a group discussion to formulate regulatory pathways. The ocular surface and its secondary lymphoid tissues contain numerous components of the innate and adaptive immune systems, which modulate the immune response to suppress or prevent excessive damaging immune reactions. These include factors that regulate induction of the immune response (afferent loop), as well as effector cells and soluble factors (efferent loop). The ocular surface is an immunologically active mucosal site that contains numerou... The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=2538190 Tue, 31 Mar 2009 23:00:00 +0100 2538190 http://www.medworm.com/index.php?rid=2538189&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19383276%26dopt%3DAbstract Authors: Baum J PMID: 19383276 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=2538189 Tue, 31 Mar 2009 23:00:00 +0100 2538189 http://www.medworm.com/index.php?rid=2538188&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19383277%26dopt%3DAbstract Authors: Bron AJ, Yokoi N, Gafney E, Tiffany JM This paper reviews current knowledge of the pathophysiology of dry eye and predicts that the clinical picture in late disease differs in both severity and quality from that in early disease. It is hypothesized that hybrid forms evolve, in which aqueous-deficient dry eye (ADDE) takes on features of evaporative dry eye (EDE) and vice versa. As a consequence, early and late forms may require different diagnostic criteria and respond to different therapeutic regimes. Tear hyperosmolarity plays a key role in the damage mechanism of dry eye, and ADDE is recognized to be a low-volume, hyperosmolar state. As ADDE advances, a progressive decrease in lacrimal secretion occurs, exacerbated by loss of the corneal reflex. This causes a decrease in tea... The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=2538188 Tue, 31 Mar 2009 23:00:00 +0100 2538188 http://www.medworm.com/index.php?rid=2538187&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19383278%26dopt%3DAbstract Authors: Lopin E, Deveney T, Asbell PA Impression cytology (IC) allows cells to be harvested from the ocular surface noninvasively. Superficial layers of the epithelium are removed by application of cellulose acetate filters or Biopore membranes, and the cells can be subsequently analyzed by various methods, depending on the objective of the investigation or pathology involved. IC techniques are easily learned, can be performed in an outpatient setting, and cause virtually no discomfort to the patient. IC facilitates the diagnosis of ocular surface disorders, including, among others, keratoconjunctivitis sicca, ocular surface squamous neoplasia, and ocular surface infections. During the past decade, IC has been used increasingly to assist in diagnosis of ocular surface disease, improve... The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=2538187 Tue, 31 Mar 2009 23:00:00 +0100 2538187 http://www.medworm.com/index.php?rid=2538186&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19383279%26dopt%3DAbstract Authors: Novack GD PMID: 19383279 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=2538186 Tue, 31 Mar 2009 23:00:00 +0100 2538186 http://www.medworm.com/index.php?rid=2538185&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19383280%26dopt%3DAbstract Authors: Tan DT, Beuerman RW Established in 1997, the Singapore Eye Research Institute (SERI), which is the research arm of the Singapore National Eye Center (SNEC), has become one of the top centers for eye research in Southeast Asia. Because of research carried out at SERI and SNEC, Singapore now ranks as the world's top publisher of ophthalmology research on a per capita basis. Under the leadership of SERI director Donald Tan (recently succeeded by Wong Tien Yen) and scientific director Roger Beuerman, SERI has focused on the ocular surface, with particular emphasis on stem cell research, wound healing, and inflammation. PMID: 19383280 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=2538185 Tue, 31 Mar 2009 23:00:00 +0100 2538185 http://www.medworm.com/index.php?rid=2538184&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19445092%26dopt%3DAbstract Authors: O'Brien TP PMID: 19445092 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=2538184 Tue, 31 Mar 2009 23:00:00 +0100 2538184 http://www.medworm.com/index.php?rid=2265349&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19214353%26dopt%3DAbstract Authors: Nishida T PMID: 19214353 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=2265349 Thu, 01 Jan 2009 05:00:00 +0100 2265349 http://www.medworm.com/index.php?rid=2188456&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19214347%26dopt%3DAbstract Authors: Foulks GN PMID: 19214347 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=2188456 Thu, 01 Jan 2009 05:00:00 +0100 2188456 http://www.medworm.com/index.php?rid=2188455&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19214348%26dopt%3DAbstract Authors: Murube J PMID: 19214348 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=2188455 Thu, 01 Jan 2009 05:00:00 +0100 2188455 http://www.medworm.com/index.php?rid=2188454&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19214349%26dopt%3DAbstract This article reviews newly described features of SS identified in experimental animal models and their relationship to human disease. New technologies, such as genomics and proteomics, may permit identification of potential candidate genes and biomarkers for disease diagnosis. Current studies using appropriate animal models in parallel with studies of human subjects are rapidly establishing a foundation for new intervention strategies that go beyond merely treating symptoms. PMID: 19214349 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=2188454 Thu, 01 Jan 2009 05:00:00 +0100 2188454 http://www.medworm.com/index.php?rid=2188453&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19214350%26dopt%3DAbstract Authors: Rosenthal P, Baran I, Jacobs DS ABSTRACT Clinicians often encounter patients who report corneal pain suggestive of dry eye disease, yet lack equivalent signs. These patients represent a diagnostic and therapeutic challenge that is more easily dismissed than addressed. We review the physiology of pain and the pathophysiological mechanisms of neuropathic corneal pain and speculate on the mechanisms of certain etiopathogenic triggers, such as LASIK, severe dry eye disease, and Sjogren syndrome. Recognizing corneal neuropathic pain as a disease in its own right is the first step toward developing more effective treatments for these severely disabled and presently inadequately served patients. PMID: 19214350 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=2188453 Thu, 01 Jan 2009 05:00:00 +0100 2188453 http://www.medworm.com/index.php?rid=2188452&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19214351%26dopt%3DAbstract Authors: Labbé A, Khammari C, Dupas B, Gabison E, Brasnu E, Labetoulle M, Baudouin C ABSTRACT Infectious keratitis can lead to irreversible complications and even blindness. Identifying the infectious agent in this condition is a challenge for the ophthalmologist. Corneal cultures are considered to be the gold standard diagnostic tool for this condition. Nevertheless, routine culture and viral investigations may yield positive results in only half the cases. In vivo confocal microscopy (IVCM) is a noninvasive imaging technique that provides high-resolution images of all the corneal layers. Since accurate and rapid diagnosis is important for the management and outcome of infectious keratitis, this disease constitutes one of the most important clinical uses of IVCM. However, in this... The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=2188452 Thu, 01 Jan 2009 05:00:00 +0100 2188452 http://www.medworm.com/index.php?rid=2188451&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19214352%26dopt%3DAbstract The "In-between" New Drug Application. Ocul Surf. 2009 Jan;7(1):53-5 Authors: Novack GD PMID: 19214352 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=2188451 Thu, 01 Jan 2009 05:00:00 +0100 2188451 http://www.medworm.com/index.php?rid=2188450&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19214353%26dopt%3DAbstract Authors: Nishida T PMID: 19214353 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=2188450 Thu, 01 Jan 2009 05:00:00 +0100 2188450 http://www.medworm.com/index.php?rid=1845330&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18827946%26dopt%3DAbstract Authors: Foulks GN PMID: 18827946 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=1845330 Wed, 01 Oct 2008 04:00:00 +0100 1845330 http://www.medworm.com/index.php?rid=1845329&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18827947%26dopt%3DAbstract Authors: PMID: 18827947 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=1845329 Wed, 01 Oct 2008 04:00:00 +0100 1845329 http://www.medworm.com/index.php?rid=1845328&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18827948%26dopt%3DAbstract Authors: Murube J PMID: 18827948 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=1845328 Wed, 01 Oct 2008 04:00:00 +0100 1845328 http://www.medworm.com/index.php?rid=1845327&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18827949%26dopt%3DAbstract Authors: Rocha EM, Alves M, Rios JD, Dartt DA ABSTRACT The afferent nerves of the cornea and conjunctiva, efferent nerves of the lacrimal gland, and the lacrimal gland are a functional unit that works cooperatively to produce the aqueous component of tears. A decrease in the lacrimal gland secretory function can lead to dry eye disease. Because aging is a risk factor for dry eye disease, study of the changes in the function of the lacrimal gland functional unit with age is important for developing treatments to prevent dry eye disease. No one mechanism is known to induce the changes that occur with aging, although multiple different mechanisms have been associated with aging. These fall into two theoretical categories: programmed theories of aging (immunological, genetic, apoptotic, an... The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=1845327 Wed, 01 Oct 2008 04:00:00 +0100 1845327 http://www.medworm.com/index.php?rid=1845326&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18827950%26dopt%3DAbstract Authors: Jacob JT, Ham B ABSTRACT Identification of tear film proteins and lipids is important for the elucidation of contact lens incompatibilities, tear film instabilities, dry eye syndromes, and other eye diseases. Compositional analysis of the tear film has been hampered in the past by the complex nature of the fluid and small sample size. Previously, all analytical methods required pooling of tear samples and molecular manipulation for detection of proteins and lipids, all of which skewed the resultant data. With the advent of nanoscale detection and analysis methods, it has become possible to identify specific tear components. This paper reviews the recent advances in tear sampling, proteomics, and lipidomics. Compositional profiling techniques, such as multi-dimensional electrop... The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=1845326 Wed, 01 Oct 2008 04:00:00 +0100 1845326 http://www.medworm.com/index.php?rid=1845325&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18827951%26dopt%3DAbstract Authors: Vanathi M, Panda A, Kai S, Sen S ABSTRACT Reports of corneal keloids are rare, with fewer than 80 cases published since the first case was documented in 1865. Keloids can be congenital or primary, but most often are associated with ocular surface injury or pathology. They have been reported in association with a number of congenital conditions, notably lowe's syndrome. Keloids are characterized histopathologically by a haphazard arrangement of fibroblasts, collagen bundles, and blood vessels. They have sometimes been confused with hypertrophic scars, but differ from such scars in that they may appear months or years after initial trauma and enlarge over time. The underlying cornea may be clear and uninvolved, or it may be opaque, depending on the primary pathology of the keloi... The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=1845325 Wed, 01 Oct 2008 04:00:00 +0100 1845325 http://www.medworm.com/index.php?rid=1845324&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18827952%26dopt%3DAbstract Authors: Novack GD PMID: 18827952 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=1845324 Wed, 01 Oct 2008 04:00:00 +0100 1845324 http://www.medworm.com/index.php?rid=1794938&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18781261%26dopt%3DAbstract Authors: Holly FJ PMID: 18781261 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=1794938 Tue, 01 Jul 2008 04:00:00 +0100 1794938 http://www.medworm.com/index.php?rid=1783171&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18781255%26dopt%3DAbstract Authors: Foulks GN PMID: 18781255 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=1783171 Tue, 01 Jul 2008 04:00:00 +0100 1783171 http://www.medworm.com/index.php?rid=1783170&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18781256%26dopt%3DAbstract Authors: Murube J PMID: 18781256 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=1783170 Tue, 01 Jul 2008 04:00:00 +0100 1783170 http://www.medworm.com/index.php?rid=1783169&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18781257%26dopt%3DAbstract Authors: Pearlman E, Johnson A, Adhikary G, Sun Y, Chinnery HR, Fox T, Kester M, McMenamin PG Abstract The Toll-like receptor (TLR) family of pathogen recognition molecules has an important role in recognizing microbial pathogens and microbial breakdown products. Activation of TLRs in the corneal epithelium induces CXC chemokine production and recruitment of neutrophils to the corneal stroma. Although essential for pathogen killing, neutrophils can cause extensive tissue damage, leading to visual impairment and blindness. In this review, we examine the role of TLRs in microbial keratitis and in noninfectious corneal inflammation, most commonly associated with contact lens wear. we present recent findings on TLR signaling pathways in the cornea, including MyD88- and TRIF-dependent respo... The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=1783169 Tue, 01 Jul 2008 04:00:00 +0100 1783169 http://www.medworm.com/index.php?rid=1783168&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18781258%26dopt%3DAbstract Authors: Simpson T, Fonn D ABSTRACT Perhaps no diagnostic technology has emerged as rapidly in ophthalmology as optical coherence tomography (OCT). A single clinical device for this noninvasive imaging technique was first released in 1996, and now at least ten clinical devices are available. Although the first clinical anterior segment OCT was marketed only 2 years ago, a substantial amount of work has been done using modified retinal imagers or prototype laboratory-based imagers. In this review, we discuss OCT imaging primarily of the cornea. We also highlight previous and current publications on nonclinical and clinical uses of the device to illustrate how anterior segment OCT can be used to understand corneal structure and function in health and disease. PMID: 18781258 [PubMed -... The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=1783168 Tue, 01 Jul 2008 04:00:00 +0100 1783168 http://www.medworm.com/index.php?rid=1783167&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18781259%26dopt%3DAbstract Authors: Saw VP, Dart JK Abstract Ocular mucous membrane pemphigoid presents some of the most challenging dilemmas in anterior segment management. Diagnosis is made difficult by the insensitivity of immunopathological investigations and the differential diagnosis of other scarring conjunctival disorders. The management of the associated ocular surface disease involves control of blepharitis, dry eye, filamentary keratitis, keratinization, lid malposition, and persistent epithelial defect, as well as the identification and avoidance of toxicity. Inflammation associated with the underlying disorder demands the use of systemic immunosuppressive therapy in many patients. New biological immunotherapies have been used when conventional immunosuppressive therapies fail. Ophthalmic plastic sur... The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=1783167 Tue, 01 Jul 2008 04:00:00 +0100 1783167 http://www.medworm.com/index.php?rid=1783166&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18781260%26dopt%3DAbstract Authors: Novack GD PMID: 18781260 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=1783166 Tue, 01 Jul 2008 04:00:00 +0100 1783166 http://www.medworm.com/index.php?rid=1783165&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18781261%26dopt%3DAbstract Authors: Holly FJ PMID: 18781261 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=1783165 Tue, 01 Jul 2008 04:00:00 +0100 1783165 http://www.medworm.com/index.php?rid=1382770&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18418502%26dopt%3DAbstract Authors: Foulks GN PMID: 18418502 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=1382770 Tue, 01 Apr 2008 04:00:00 +0100 1382770 http://www.medworm.com/index.php?rid=1382769&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18418503%26dopt%3DAbstract Authors: Murube J PMID: 18418503 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=1382769 Tue, 01 Apr 2008 04:00:00 +0100 1382769 http://www.medworm.com/index.php?rid=1382768&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18418504%26dopt%3DAbstract Authors: Manzouri B, Flynn T, Ohbayashi M, Ono SJ ABSTRACT The acquired immune response in health and disease is initiated when foreign antigens are processed and presented to T lymphocytes via antigen-presenting cells as peptides in the context of Class I and II major histocompatibility complex antigens. It is now clear that there are various types of antigen-presenting cells and that the phenotype of these cells (together with the milieu of the tissue or lymphoid organ) dictates the nature of the immune response to the antigen. Very little is known about the phenotype, distribution, and roles of dendritic cell subtypes that contribute to the pathophysiology of type I hypersensitivity reaction in the ocular surface. We review what has been learned from studies of both human ocular all... The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=1382768 Tue, 01 Apr 2008 04:00:00 +0100 1382768 http://www.medworm.com/index.php?rid=1382767&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18418505%26dopt%3DAbstract Authors: Cher I ABSTRACT The concept of the dacruon was presented by the author in this journal in July 2007. Dacruon, defined as "the body of unshed fluid, constantly occupying the ocular surface sac [OSS], comprising the mucoaqueous pool [MAP] and its covering lipid sealant," prompts a fresh consideration of OSS lubrication. The author notes scientific agreement that in the preocular, interpalpebral OSS (the menisco-optical domain), the mucous gel of the MAP adheres to subjacent bulbar epithelium. In the retropalpebral recesses (the "lubrication domain"), lid and globe epithelia are juxtaposed. The author proposes that microvilli and glycocalyx "grasp" the bases of dacruon mucous gels, enabling lid and globe to "drive" fluid movement. The adherent gels and associated low viscosity mu... The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=1382767 Tue, 01 Apr 2008 04:00:00 +0100 1382767 http://www.medworm.com/index.php?rid=1382766&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18418506%26dopt%3DAbstract Authors: Gregory DG ABSTRACT Stevens-Johnson syndrome (SJS) and its more severe variant, toxic epidermal necrolysis (TEN), cause significant ocular surface damage. The majority of affected patients develop conjunctival inflammation during the acute phase of the disease. If intense, this inflammation yields permanent destruction of the normal mucosal tissue of the ocular surface and eyelids. Loss of the normal glandular structures leads to severe dry eye problems and vision loss. Medical treatments do little to arrest these problems, and repairing the damage after the acute phase is difficult, if not impossible. Recently, the application of cryopreserved amniotic membrane to the ocular surface during the acute phase of the disease has shown great promise in limiting the destructive infl... The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=1382766 Tue, 01 Apr 2008 04:00:00 +0100 1382766 http://www.medworm.com/index.php?rid=1382765&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18418507%26dopt%3DAbstract Authors: Tiffany JM PMID: 18418507 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=1382765 Tue, 01 Apr 2008 04:00:00 +0100 1382765 http://www.medworm.com/index.php?rid=1382764&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18418508%26dopt%3DAbstract Authors: Novack GD PMID: 18418508 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=1382764 Tue, 01 Apr 2008 04:00:00 +0100 1382764 http://www.medworm.com/index.php?rid=1225927&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18264650%26dopt%3DAbstract Authors: Foulks GN PMID: 18264650 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=1225927 Tue, 01 Jan 2008 05:00:00 +0100 1225927 http://www.medworm.com/index.php?rid=1225926&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18264651%26dopt%3DAbstract Authors: Murube J ABSTRACT Although a number of hypotheses exist to explain the reasons for the rapid eye movement (REM) phase of sleep, the physical movements themselves have not been explained or interpreted in the literature. The author theorizes that REM during sleep serves not only to increase the lacrimal secretion and to humidify and lubricate the ocular surface, but also to redistribute the secretion on the ocular surface and to inform the conjunctiva-associated lymphoid tissue (CALT) system. He hypothesizes that when eyes move in REM periods to humidify the ocular surface, they indirectly release phenomena of the visual activity, producing dreams. PMID: 18264651 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=1225926 Tue, 01 Jan 2008 05:00:00 +0100 1225926 http://www.medworm.com/index.php?rid=1225925&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18264652%26dopt%3DAbstract Authors: Kao WW, Xia Y, Liu CY, Saika S ABSTRACT Interactions and signaling between mesenchymal and epithelial cells are essential for morphogenesis, organogenesis, cell differentiation, and growth of cornea and eyelids during embryogenesis. These bidirectional interactions are mediated by complex regulatory networks that coordinate the proliferation, differentiation, and cell fate determination involved in tissue morphogenesis. All the signaling pathways involved are indispensable, but it is not clear whether each acts alone or whether they integrate to control events in various aspects of ocular surface development. This review discusses known signaling transduction pathways involved in the morphogenesis of the cornea and eyelids during embryonic development and homeostasis in adults... The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=1225925 Tue, 01 Jan 2008 05:00:00 +0100 1225925 http://www.medworm.com/index.php?rid=1225924&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18264653%26dopt%3DAbstract Authors: Chui J, Di Girolamo N, Wakefield D, Coroneo MT ABSTRACT Pterygium is a disease of the ocular surface that is associated with chronic UV exposure and is characterized by proliferation, inflammatory infiltrates, fibrosis, angiogenesis and extracellular matrix breakdown. Although pterygium is not fully understood, significant progress has been made toward understanding the mechanisms involved in its pathogenesis. In this review, we provide an update on the signaling pathways activated by UV light that result in induction of mediators responsible for the growth of pterygium. We also review the recent genetic studies on hereditary factors and provide a brief overview of the role of epithelial mesenchymal transition, bone marrow progenitor cells, and neuronal signals that may also c... The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=1225924 Tue, 01 Jan 2008 05:00:00 +0100 1225924 http://www.medworm.com/index.php?rid=1225923&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18264654%26dopt%3DAbstract Authors: Alves M, Dias AC, Rocha EM ABSTRACT Because dry eye disease is rare in children and its pathogenesis is less well known than in adults, its diagnosis is often overlooked. It can occur in association with a number of congenital, autoimmune, endocrine, and inflammatory disorders, or under certain environmental and nutritional conditions. In some cases, early detection allows the underlying cause of the dry eye to be successfully treated and eliminated. In other cases, the disease may represent a lifelong problem, whose proper management can prevent ulceration and scarring of the ocular surface. Because of the association of pediatric dry eye with other conditions, a multidisciplinary approach to diagnosis and treatment is usually required. The purpose of this review is to enhanc... The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=1225923 Tue, 01 Jan 2008 05:00:00 +0100 1225923 http://www.medworm.com/index.php?rid=1225922&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18264655%26dopt%3DAbstract Authors: Novack GD PMID: 18264655 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=1225922 Tue, 01 Jan 2008 05:00:00 +0100 1225922 http://www.medworm.com/index.php?rid=1225921&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18264656%26dopt%3DAbstract Authors: Korb DR PMID: 18264656 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=1225921 Tue, 01 Jan 2008 05:00:00 +0100 1225921 http://www.medworm.com/index.php?rid=957564&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17938834%26dopt%3DAbstract Authors: Foulks GN PMID: 17938834 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=957564 Mon, 01 Oct 2007 04:00:00 +0100 957564 http://www.medworm.com/index.php?rid=957563&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17938835%26dopt%3DAbstract Authors: Murube J PMID: 17938835 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=957563 Mon, 01 Oct 2007 04:00:00 +0100 957563 http://www.medworm.com/index.php?rid=957562&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17938836%26dopt%3DAbstract Authors: PMID: 17938836 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=957562 Mon, 01 Oct 2007 04:00:00 +0100 957562 http://www.medworm.com/index.php?rid=957561&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17938837%26dopt%3DAbstract Authors: Gukasyan HJ, Kim KJ, Lee VH, Kannan R ABSTRACT Glutathione (GSH) is an abundant antioxidant ubiquitous in nearly all cell types. Deficiency of GSH has been linked to ocular disease and viral infection. Other established vital roles of GSH include detoxification and immunoprotection. Endogenous GSH plays a protagonist's role in safeguarding active transport processes compartmentalized at the interface between conjunctival mucosa and the tear film. Optimal electrokinetic transport across the conjunctival epithelium requires the mucosal presence of GSH. Glutathione is the most abundant known endogenous antioxidant molecule in tear fluid, mainly derived from conjunctival secretion. Conjunctival GSH transport, a major kinetic component of GSH turnover, occurs through multiple funct... The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=957561 Mon, 01 Oct 2007 04:00:00 +0100 957561 http://www.medworm.com/index.php?rid=957560&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17938838%26dopt%3DAbstract Authors: Baca JT, Finegold DN, Asher SA ABSTRACT One approach to the noninvasive monitoring of blood glucose concentration is to monitor glucose concentrations in tear fluid. While several methods for sensing glucose in tear fluid have been proposed, controversy remains as to the precise concentrations of tear glucose in normal and diabetic subjects and as to whether tear fluid glucose concentrations correlate with blood glucose concentrations. This review covers the present understanding of the physiology of glucose transport in tears, the regulation of the aqueous tear fraction, and studies of tear glucose concentration over the last 80 years. The various tear collection methods employed greatly influence the measured tear glucose concentrations. Studies that involve mechanical irrit... The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=957560 Mon, 01 Oct 2007 04:00:00 +0100 957560 http://www.medworm.com/index.php?rid=957559&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17938839%26dopt%3DAbstract Authors: Sindt CW, Longmuir RA ABSTRACT Dry eye is the most common reason for contact lens (CL) discontinuation, and the patient with pre-existing dry eye presents particular challenges to the CL fitter. Poor tear film quality/stability, oxygen deprivation, lens deposits, and adverse reactions to CL solutions all contribute to dry eye, and lid disease, allergies, environmental factors, and medications can further hamper successful CL wear by the patient with dry eye. Health and comfort of the ocular surface is affected by the water content, ionicity, oxygen permeability, and modulus of elasticity of the lens, as well as by surface characteristics, such as protein, lipid, and mucin deposition; protein adsorption; and wettability. The choice of CL cleaning solutions with regard to action... The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=957559 Mon, 01 Oct 2007 04:00:00 +0100 957559 http://www.medworm.com/index.php?rid=957558&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17938840%26dopt%3DAbstract In this study, a significant correlation was found between cumulative lifetime computer use and ocular surface disorder, as measured by the standardized OSDI index. The experimental and control subjects were significantly different (P < 0.05) in the meibomian gland assessment and TBUT; they were consistently different in fluorescein and lissamine green staining, but with P > 0.05. Isolation of the ocular surface alone produced significant improvements in comfort scores and TBUT and a consistent trend of improvement in fluorescein staining and lissamine green staining. Isolation plus tears produced a significant improvement in lissamine green staining. The subjective comfort inventory and the tbut test were most effective in distinguishing between the treatments used. Computer users w... The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=957558 Mon, 01 Oct 2007 04:00:00 +0100 957558 http://www.medworm.com/index.php?rid=957557&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17938841%26dopt%3DAbstract Authors: Novack GD PMID: 17938841 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=957557 Mon, 01 Oct 2007 04:00:00 +0100 957557 http://www.medworm.com/index.php?rid=957556&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17938842%26dopt%3DAbstract Authors: Meadows D, Krueger S PMID: 17938842 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=957556 Mon, 01 Oct 2007 04:00:00 +0100 957556 http://www.medworm.com/index.php?rid=922333&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17660893%26dopt%3DAbstract Authors: Foulks GN PMID: 17660893 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=922333 Sun, 01 Jul 2007 04:00:00 +0100 922333 http://www.medworm.com/index.php?rid=922332&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17660894%26dopt%3DAbstract Authors: Murube J PMID: 17660894 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=922332 Sun, 01 Jul 2007 04:00:00 +0100 922332 http://www.medworm.com/index.php?rid=922331&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17660895%26dopt%3DAbstract Authors: Evans DJ, McNamara NA, Fleiszig SM The ocular surface usually looks quiet, presenting a general impression of biological inactivity. Yet, the ability of the cornea to maintain health while continually exposed to environmental insults, and in the relative absence of immune strategies afforded by other body sites, reflects its complexity. Because it is critical for transparency and, therefore, our survival, the fine structure of the cornea has likely provided the driving force for the evolution of what appears to be a truly remarkable system. While several molecules are now known to participate, we are only beginning to obtain the knowledge to fully explain the mechanisms involved in corneal resistance to infection. Full explanation will require a better understanding of the int... The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=922331 Sun, 01 Jul 2007 04:00:00 +0100 922331 http://www.medworm.com/index.php?rid=922330&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17660896%26dopt%3DAbstract Authors: Klenkler B, Sheardown H, Jones L Numerous biologically active growth factors are secreted by the lacrimal gland and distributed via the tears over the ocular surface, where they affect cellular proliferation, migration, differentiation, and survival. The role of growth factors and their receptors in maintenance of tissue homeostasis and wound healing continues to be elucidated, and the effect of growth factor imbalances in ocular surface diseases is just beginning to be understood. For instance, in eyes with ocular surface diseases, including conjunctivitis, corneal erosion, keratitis, and corneal ulcers, epidermal growth factor release rates have been shown to be significantly lower than in normal eyes during reflex tearing. Future research into the mechanisms of dry eye dise... The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=922330 Sun, 01 Jul 2007 04:00:00 +0100 922330 http://www.medworm.com/index.php?rid=922329&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17660897%26dopt%3DAbstract Authors: Guess S, Stone DU, Chodosh J Herpes simplex virus (HSV) keratitis is a common cause of ocular and visual morbidity. In this article, we systematically review published randomized clinical trials (RCTs) for HSV epithelial and stromal keratitis in order to establish a rational evidence-based foundation for treatment of these disorders. Articles for review were identified in the MEDLINE database from January 1, 1966, to May 30, 2006. Our review criteria stipulated that each study be performed in prospective, randomized, and double-blinded fashion, that it be controlled, and that it rely on specific clinical criteria for diagnosis and outcome. Of articles thus identified in the English language press, 38 articles met our review criteria, 30 for HSV epithelial keratitis and 8 (comp... The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=922329 Sun, 01 Jul 2007 04:00:00 +0100 922329 http://www.medworm.com/index.php?rid=922328&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17660898%26dopt%3DAbstract Another way to think of tears: blood, sweat, and... "dacruon". Ocul Surf. 2007 Jul;5(3):251-4 Authors: Cher I Eugene Wolff's 1946 concept of an interpalpebral, trilaminar, preocular tear film does not sit comfortably with more recent scientific observations. A film so defined could exist only in the interblink phase and would exclude unshed retropalpebral fluid. A modern, evidence-based, clinically relevant model is needed, one that includes retropalpebral and meniscal fluids and is applicable throughout the blink cycle. The "ocular surface" (OS) concept combines adjacent discrete epithelia into a single continuous mucosal sheet. This "surface" constitutes an integrated organ. The OS concept has revolutionized the understanding and management of ocular pathology and therapeutic... The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=922328 Sun, 01 Jul 2007 04:00:00 +0100 922328 http://www.medworm.com/index.php?rid=922327&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17660899%26dopt%3DAbstract Authors: Novack GD PMID: 17660899 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=922327 Sun, 01 Jul 2007 04:00:00 +0100 922327 http://www.medworm.com/index.php?rid=922326&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17660900%26dopt%3DAbstract Authors: Nichols KK, Nichols JJ PMID: 17660900 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=922326 Sun, 01 Jul 2007 04:00:00 +0100 922326 http://www.medworm.com/index.php?rid=922325&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17660901%26dopt%3DAbstract Authors: PMID: 17660901 [PubMed - in process] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=922325 Sun, 01 Jul 2007 04:00:00 +0100 922325 http://www.medworm.com/index.php?rid=922339&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17508116%26dopt%3DAbstract Authors: Lemp MA, Baudouin C, Baum J, Dogru M, Foulks GN, Kinoshita S, Laibson P, McCulley J, Murube J, Pfugfelder SC, Rolando M, Toda I The aim of the DEWS Definition and Classification Subcommittee was to provide a contemporary definition of dry eye disease, supported within a comprehensive classification framework. A new definition of dry eye was developed to reflect current understanding of the disease, and the committee recommended a three-part classification system. The first part is etiopathogenic and illustrates the multiple causes of dry eye. The second is mechanistic and shows how each cause of dry eye may act through a common pathway. It is stressed that any form of dry eye can interact with and exacerbate other forms of dry eye, as part of a vicious circle. Finally, a schem... The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=922339 Sun, 01 Apr 2007 04:00:00 +0100 922339 http://www.medworm.com/index.php?rid=922338&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17508117%26dopt%3DAbstract Authors: Smith JA, Albeitz J, Begley C, Caffery B, Nichols K, Schaumberg D, Schein O The report of the Epidemiology Subcommittee of the 2007 Dry Eye WorkShop summarizes current knowledge on the epidemiology of dry eye disease, providing prevalence and incidence data from various populations. It stresses the need to expand epidemiological studies to additional geographic regions, to incorporate multiple races and ethnicities in future studies, and to build a consensus on dry eye diagnostic criteria for epidemiological studies. Recommendations are made regarding several characteristics of dry eye questionnaires that might be suitable for use in epidemiological studies and randomized controlled clinical trials. Risk factors for dry eye and morbidity of the disease are identified, and the ... The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=922338 Sun, 01 Apr 2007 04:00:00 +0100 922338 http://www.medworm.com/index.php?rid=922337&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17508118%26dopt%3DAbstract This report provides a general overview of the criteria applied in the development of tests for screening and diagnosis. PMID: 17508118 [PubMed - indexed for MEDLINE] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=922337 Sun, 01 Apr 2007 04:00:00 +0100 922337 http://www.medworm.com/index.php?rid=922336&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17508119%26dopt%3DAbstract This report summarizes some universal concepts with regard to clinical trials in general and other issues pertaining to clinical trials specifically tailored to the study of therapeutic intervention in dry eye disease. The report also makes recommendations for logistical design and implementation of such trials. It identifies peculiarities of dry eye disease that complicate clinical trial design, such as the lack of correlation of signs and symptoms, as well as the likelihood of control interventions having a lubricant (placebo) effect. Strategies for environmental trials and controlled adverse environment trials are reviewed. PMID: 17508119 [PubMed - indexed for MEDLINE] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=922336 Sun, 01 Apr 2007 04:00:00 +0100 922336 http://www.medworm.com/index.php?rid=922335&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17508120%26dopt%3DAbstract Authors: Pflugfelder SC, Geerling G, Kinoshita S, Lemp MA, McCulley J, Nelson D, Novack GN, Shimazaki J, Wilson C The members of the Management and Therapy Subcommittee assessed current dry eye therapies. Each member wrote a succinct evidence-based review on an assigned aspect of the topic, and the final report was written after review by and with consensus of all subcommittee members and the entire Dry Eye WorkShop membership. In addition to its own review of the literature, the Subcommittee reviewed the Dry Eye Preferred Practice Patterns of the American Academy of Ophthalmology and the International Task Force (ITF) Delphi Panel on Dry Eye. The Subcommittee favored the approach taken by the ITF, whose recommended treatments were based on level of disease severity. the recommendation... The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=922335 Sun, 01 Apr 2007 04:00:00 +0100 922335 http://www.medworm.com/index.php?rid=922334&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17508121%26dopt%3DAbstract Authors: Gipson IK, Argüeso P, Beuerman R, Bonini S, Butovich I, Dana R, Dartt D, Gamache D, Ham B, Jumblatt M, Korb D, Kruse F, Ogawa Y, Paulsen F, Stern M, Sweeney DF, Tiffany J, Ubels J, Willcox M Members of the DEWS Research Subcommittee reviewed research into the basic mechanisms underlying dry eye disease. Evidence was evaluated concerning the tear film, lacrimal gland and accessory lacrimal glands, ocular surface epithelia (including cornea and conjunctiva), meibomian glands, lacrimal duct system and the immune system. Consideration was given to both animal and human research data. Results are presented as a series of information matrices, identifying what is known and providing supporting references. An attempt is made to identify areas for further investigation. PMID:... The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=922334 Sun, 01 Apr 2007 04:00:00 +0100 922334 http://www.medworm.com/index.php?rid=922346&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17252161%26dopt%3DAbstract Authors: Murube J PMID: 17252161 [PubMed - indexed for MEDLINE] (Source: The Ocular Surface) The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=922346 Mon, 01 Jan 2007 05:00:00 +0100 922346 http://www.medworm.com/index.php?rid=922345&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17252162%26dopt%3DAbstract Authors: Lorber M ABSTRACT Because human lacrimal glands are rarely completely removed at surgery and not extirpated during routine autopsy, knowledge of their normal measurements and orbital position has not been significantly updated from early descriptions. Judged retrospectively, these have appreciable shortcomings. For example, most published lacrimal gland weights and dimensions have not always been accompanied by such basic information as the mean or range of values, the number of glands examined, the donors' genders and ages, and whether the specimens came from living donors (exenteration), recently deceased ones (autopsy), or embalmed cadavers. Consequently, it is appropriate to survey the literature about a fundamental aspect of this major contributor to aqueous tear secretio... The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=922345 Mon, 01 Jan 2007 05:00:00 +0100 922345 http://www.medworm.com/index.php?rid=922344&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17252163%26dopt%3DAbstract Authors: Tuli SS, Schultz GS, Downer DM ABSTRACT Corneal ulcers can cause significant loss of vision from scarring and astigmatism, but rapid management can limit the destruction and improve outcomes. Infectious ulcers usually resolve with antimicrobial treatment. Noninfectious ulcers, however, present a diagnostic and therapeutic challenge. They can often be resolved by eliminating toxic medications and providing surface support with lubrication and collagenase inhibitors, but resistant ulcers may need more aggressive therapy with bandage contact lenses, tarsorrhaphy, or autologous serum. Ulcers impending perforation require urgent surgical management (e.g., tissue glue, conjunctival flaps, or keratoplasty). Topical steroids are useful when the ulceration is secondary to inflammatory ... The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=922344 Mon, 01 Jan 2007 05:00:00 +0100 922344 http://www.medworm.com/index.php?rid=922343&cid=s_36418_30_f&fid=36418&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17252164%26dopt%3DAbstract Authors: Pullum K, Buckley R ABSTRACT Contrary to popular perception, the large size and scleral bearing surface of scleral contact lenses (ScCLs) can be beneficial in the management of certain ocular surface disorders. They can provide retention of a precorneal tear reservoir for corneal hydration with total protection from the external environment and from the lid margins and lashes. They can relieve pain, prevent exposure keratitis, and enhance epithelial healing. The use of ScCLs is limited in large part by ophthalmologists' perception of excessive complexity. Actually, while some cases are challenging, many are straightforward. This review summarizes indications for therapeutic use of ScCLs and describes techniques and considerations that contribute to their clinical success. ... The Ocular Surface journals http://www.medworm.com/rss/comments.php?id=922343 Mon, 01 Jan 2007 05:00:00 +0100 922343