MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Thrombosis Research' source. Wed, 08 Feb 2012 17:42:13 +0100 http://www.medworm.com/index.php?rid=5598829&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384812000114%2Fabstract%3Frss%3Dyes (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5598829 Tue, 17 Jan 2012 23:05:32 +0100 5598829 http://www.medworm.com/index.php?rid=5458920&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811005597%2Fabstract%3Frss%3Dyes Conclusions: The prevalence of pulmonary embolism in hospitalized patients was higher in obese patients than in non-obese patients. Mortality in patients with pulmonary embolism was lower in obese patients than in non-obese patients, with the greatest effects in women, older patients and stable patients. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5458920 Mon, 14 Nov 2011 05:00:00 +0100 5458920 http://www.medworm.com/index.php?rid=5458919&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811005627%2Fabstract%3Frss%3Dyes The NATF CORNER, which began in the June issue of Thrombosis Research, is a collaborative effort between Thrombosis Research and the North American Thrombosis Forum (NATF) to foster the publication of scholarly manuscripts in the field of Hemostasis and Thrombosis. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5458919 Mon, 07 Nov 2011 05:00:00 +0100 5458919 http://www.medworm.com/index.php?rid=5598833&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811005123%2Fabstract%3Frss%3Dyes In spite of epidemiologic studies and updated international guidelines, more than 50% of hospitalised patients for an acute medical condition do not receive prophylactic treatment for venous thrombo-embolic (VTE) disease. A systematic identification combined with a stratification of risk factors at entry might help in improving this situation. Some risk assessment models (RAMs) have been proposed, sometimes using mathematical methods or scoring scales. Their implementation and regular use requires ease of use, fast evaluation, and validation through a prospective study. Very few RAMs comply with all these pre-requisites. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5598833 Wed, 02 Nov 2011 04:00:00 +0100 5598833 http://www.medworm.com/index.php?rid=5362707&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811005329%2Fabstract%3Frss%3Dyes (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5362707 Tue, 01 Nov 2011 04:00:00 +0100 5362707 http://www.medworm.com/index.php?rid=5598848&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811005275%2Fabstract%3Frss%3Dyes Oxidative modifications of cell membrane lipids and of circulating lipoproteins induced by oxygen reactive species play a key role in thrombogenesis and atherogenesis. F2-isoprostanes are prostaglandins (PG) derived from a non-enzymatic process of lipid peroxidation catalysed by oxygen free radicals. In addition to its generation by free radical catalyzed mechanisms, 8-iso-PGF2α (known as iPF2α-III) may be formed by and activate human platelets, an observation linking in vivo oxidative stress to the risk of thrombosis. An abnormally high iPF2α-III urinary excretion has been reported in subjects at high cardiovascular risk and in a variety of disease settings . A link between hyperhomocysteinemia (HHcy), F2-isoprostanes and premature arteriothrombosis has been documented . (Source: Throm... Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5598848 Mon, 31 Oct 2011 04:00:00 +0100 5598848 http://www.medworm.com/index.php?rid=5598847&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811005226%2Fabstract%3Frss%3Dyes The sad story of the death of a 20year-old man who succumbed to pulmonary embolism following prolonged immobility, due to playing computer games for several hours, was lately reported in the media. Venous thromboembolism (VTE) is the third most common vascular disorder after myocardial infarction and stroke. Nevertheless and despite all such catastrophic events, it is yet to be recognized among the priorities of international bodies such as the World Health Organization. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5598847 Mon, 31 Oct 2011 04:00:00 +0100 5598847 http://www.medworm.com/index.php?rid=5598832&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811005135%2Fabstract%3Frss%3Dyes Abstract: Cardiovascular diseases are one of the leading causes of morbidity and mortality in industrialized countries, and although many processes play a role in the development of vascular disease, thrombosis is the primary event that precipitates stroke and acute coronary syndromes. The blood platelets are of significant importance in medicine. These cells are involved in many physiological processes, particularly haemostasis through their ability to aggregate and form clots in response to activation. In addition, these dynamic cells display activities that extend beyond thrombosis, including an important role in initiating and sustaining vascular inflammation. The expansion of knowledge from basic and clinical research has highlighted the critical position of platelets in several infla... Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5598832 Mon, 31 Oct 2011 04:00:00 +0100 5598832 http://www.medworm.com/index.php?rid=5545225&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811005147%2Fabstract%3Frss%3Dyes Dear Editors, Statins modulate procoagulant activity of platelets and platelet function and also influence endothelial function, effects which may be beneficial in the treatment of cardiovascular diseases . Endothelial cells, like most cells, release microparticles (MP) in response to cellular activation or apoptosis. These particles have a size between 0.1-1μm in diameter, and express various molecules, some of which may have biological effects . The effects of statins on endothelial microparticles (EMP) are controversial and have mostly been evaluated in cultured endothelial cells . In order to further investigate this we analyzed EMP in a double blind placebo controlled cross-over study on atorvastatin treatment in 19 patients (14 women and 5 men; 65±6years old) with peripheral arter... Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5545225 Mon, 31 Oct 2011 04:00:00 +0100 5545225 http://www.medworm.com/index.php?rid=5598849&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811005251%2Fabstract%3Frss%3Dyes Sir, a recent report on CYP2C19 gene variants cut-off levels for on-clopidogrel platelet aggregation is very interesting . Ono et al. concluded that “the cut-off levels of PRU and %inhibition to discriminate carriers of CYP2C19 reduced-function allele from noncarriers are potentiallyuseful clinically to provide optimal clopidogrel therapy in patients with stable CAD undergoing PCI .” There is little doubt that the VerifyNow could help discriminate between the carriers and no carriers. However, the exact clinical usefulness of such discrimination needs to be discussed. There are some reports suggesting a for low usefulness of monitoring of PRU and % inhibition. In a recent study by Varenhorst et al., questions on regarding "the clinical use of PRU testing to identify patients at high ri... Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5598849 Fri, 28 Oct 2011 04:00:00 +0100 5598849 http://www.medworm.com/index.php?rid=5598830&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811005238%2Fabstract%3Frss%3Dyes Whilst elevated plasma factor VIII (FVIII) levels has long been associated with increased risk of arterial disease, its potential importance as a risk factor for venous thromboembolism (VTE) only emerged more recently in the Leiden Thrombophilia Study (LETS) . In that case control study of 301 patients with first objectively confirmed VTE, elevated plasma FVIII:C levels (>150IU/dL) were shown to be a common finding (25% of patients versus 11% of controls). Importantly, the median time interval between occurrence of VTE and blood sampling for FVIII:C measurement was 18months, with a minimum of 6months. Moreover, in multivariate analysis, thrombotic risk increased with increasing levels of FVIII:C. Following adjustment for ABO blood group, an odds ratio of 4.8 (95% CI 2.3-10.0) for thrombosi... Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5598830 Fri, 28 Oct 2011 04:00:00 +0100 5598830 http://www.medworm.com/index.php?rid=5545223&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811005159%2Fabstract%3Frss%3Dyes An abdominal aortic aneurysm (AAA) is a potentially fatal condition with almost half of all the deaths from ruptured AAAs occurring outside the hospital. Operative mortality rate at 30days in acute surgery for ruptured AAA ranges as high as 30-40%. While operative mortality in elective surgery of AAAs has been reported to be as low as 2% to 6%. Therefore, establishing risk factors for AAA play a pivotal role in identifying patients at elevated risk and candidates for AAAs screening. Extensive data indicate a strong overlap of AAA and atherosclerosis, and that classic atherosclerosis risk factors such as male sex, age, smoking, hyperlipidemia and hypertension also predispose to AAA. Nevertheless, whether atherosclerosis and AAA might be different presentations of the same entity is controve... Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5545223 Mon, 24 Oct 2011 04:00:00 +0100 5545223 http://www.medworm.com/index.php?rid=5545209&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS004938481100510X%2Fabstract%3Frss%3Dyes Abstract: Nonvalvular atrial fibrillation is the most common clinically significant cardiac arrhythmia in the United States. It increases both the risk for and the severity of strokes and is associated with substantial morbidity, mortality, decreased quality of life, and related health care costs. Guidelines recommend anticoagulation therapy for the majority of patients with atrial fibrillation. Clinical trials have established that vitamin K antagonists are effective for stroke prevention for patients with atrial fibrillation for whom anticoagulation is recommended. However, vitamin K antagonists remain underutilized for a variety of reasons, including drug, physician, and patient factors. While vitamin K antagonists considerably reduce the risk of stroke, the absolute risk reduction vari... Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5545209 Mon, 24 Oct 2011 04:00:00 +0100 5545209 http://www.medworm.com/index.php?rid=5598831&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811005007%2Fabstract%3Frss%3Dyes Abstract: Thromboembolic disorders are a major cause of morbidity and mortality, and the risk of thromboembolism increases with age. Anticoagulants are recommended for indications including the prevention of venous thromboembolism in surgical and medical patients, treatment of venous thromboembolism and stroke prevention in patients with atrial fibrillation. Traditional anticoagulants that have been used include unfractionated heparin, low molecular weight heparin, fondaparinux and vitamin K antagonists. However, these agents are all associated with drawbacks (i.e. parenteral administration or frequent coagulation monitoring/dose titration), and it has been particularly challenging to treat elderly patients with anticoagulants. Some specific characteristics of elderly patients may influenc... Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5598831 Thu, 20 Oct 2011 04:00:00 +0100 5598831 http://www.medworm.com/index.php?rid=5545224&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811005044%2Fabstract%3Frss%3Dyes Essential thrombocytemia (ET) results from a myeloproliferative disorder characterized by primary high platelet generation . ET is frequently associated with thrombotic and bleeding complications linked to the increased number of circulating platelets and frequent acquired thrombocytopathia . (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5545224 Thu, 20 Oct 2011 04:00:00 +0100 5545224 http://www.medworm.com/index.php?rid=5545227&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811004889%2Fabstract%3Frss%3Dyes Rivaroxaban is an orally active, specific and reversible inhibitor of activated factor X (FXa) exhibiting dose proportional pharmacokinetics. The half-life of rivaroxaban ranges between seven to eleven hours . When rivaroxaban is given at doses ranging from 5 to 40mg once daily, its peak concentration in plasma is achieved within 2 hours and it is between 100ng/ml to 500ng/ml . A dose-dependent prolongation of prothrombin time (PT) and activated partial thromboplastin time (aPTT) is also observed during treatment with rivaroxaban . Rivaroxaban has been approved for the prevention of venous thromboembolism after total hip or knee replacement surgery. Recent studies show that rivaroxaban has a favorable benefit/risk ratio in long-term treatment of venous thromboembolism and in the prevention... Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5545227 Fri, 14 Oct 2011 04:00:00 +0100 5545227 http://www.medworm.com/index.php?rid=5598842&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811005111%2Fabstract%3Frss%3Dyes Abstract: We determined in a prospective cohort of patients treated with vitamin K antagonists for venous thrombosis, the course of factor VIII (FVIII:C), C-reactive protein (CRP) and fibrinogen levels, to assess the influence of the acute phase reaction on FVIII:C levels. Second, we hypothesized that patients with preceding infectious symptoms might have higher levels of FVIII:C at baseline than patients without those.We included 75 patients. Blood was sampled at baseline, once during treatment (t=1) and at the end of treatment (t=2). Mean levels of FVIII:C were 207, 186 and 175IU/dL (p for trend 0.003) at baseline, t=1 and t=2 respectively. Eight-eight percent of patients had an elevated FVIII:C at baseline, 75% at t=1 and 72% at t=2 (p for trend 0.045). Mean levels of FVIII:C were not d... Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5598842 Thu, 13 Oct 2011 04:00:00 +0100 5598842 http://www.medworm.com/index.php?rid=5458917&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS004938481100507X%2Fabstract%3Frss%3Dyes The primary mechanism of the extrinsic coagulation pathway in vivo is tissue factor (TF) binding to activated factor VII (FVIIa) . After initial activation, 2 mechanisms have been described to inhibit and control this pathway. The best understood mechanism for TF pathway inhibition is by the binding of TF pathway inhibitor (TFPI) to factor Xa, which then inhibits the TF-FVIIa complex . Since the beginning of the eight'ies the inhibition of FVIIa by antithrombin (AT) has also been reported . FVIIa is only susceptible to inhibition by AT when it is bound to TF and, different to the TFPI complex, the resulting FVIIa-AT complexes are released from TF into the circulation. The circulating levels of FVIIa-AT can be measured and reflect the degree of exposure of TF to blood. Heparin has shown to ... Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5458917 Thu, 13 Oct 2011 04:00:00 +0100 5458917 http://www.medworm.com/index.php?rid=5545222&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811005056%2Fabstract%3Frss%3Dyes Chronic thromboembolic pulmonary hypertension (CTEPH) is a complication after pulmonary embolism (PE). The incidence of CTEPH within two years after acute PE described in the literature so far is between 1% and 8% . The exact reason for the development of CTEPH is still unclear. It seems that emboli of patients are organized, leading to obstruction and narrowing of pulmonary arteries . Impaired fibrinolysis could be one reason for the development of organized thrombi. However, although abnormalities of the fibrinolytic system have been described in CTEPH-patients, the exact reason for the described impairment of fibrinolysis in these patients is still unclear . (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5545222 Wed, 12 Oct 2011 04:00:00 +0100 5545222 http://www.medworm.com/index.php?rid=5458927&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811004944%2Fabstract%3Frss%3Dyes Conclusions: The anti-inflammatory properties of Sal B on IFN-γ-induced JAK-STAT1 activation were demonstrated in the present study which provides a molecular basis for possible therapeutic usage on vascular disorders. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5458927 Wed, 12 Oct 2011 04:00:00 +0100 5458927 http://www.medworm.com/index.php?rid=5598840&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811005020%2Fabstract%3Frss%3Dyes Conclusions: AAPP inhibited whole blood aggregation induced by collagen at 10mg/kg body weight. AAPP prevented pulmonary death at a lower dose (3mg/kg) without prolongation of bleeding time compared with aspirin (100mg/kg) that compromised hemostasis. AAPP and aspirin did not affect coagulation time. These results indicate that AAPP has great potential as a new anti-platelet agent with a better risk/benefit ratio than that seen with aspirin (the most widely used anti-platelet agent). (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5598840 Tue, 11 Oct 2011 04:00:00 +0100 5598840 http://www.medworm.com/index.php?rid=5598841&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811005019%2Fabstract%3Frss%3Dyes Conclusions: The enzyme purified from the Streptomyces strain can be a potential candidate for the treatment of thrombosis. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5598841 Mon, 10 Oct 2011 04:00:00 +0100 5598841 http://www.medworm.com/index.php?rid=5362725&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811004993%2Fabstract%3Frss%3Dyes We thank Prof. Varol for his interest in our investigation . He raised several questions of concern. He had objection that the results of our study could not be gereneralized to all normal Turkish adults since MPV values were significantly higher in patients living in high altitudes . However, we think that Prof Varol missed two important points. First, we had performed our study in Yigilca and its villages that had an altitude ranging from 200m to 1200 meters. Second, the study that Prof Varol had referred was done on acute coronary syndrome patients. The potential difference in mean platelet volume in subjects living at different altitudes deserves further epidemiologic research on normal subjects. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5362725 Mon, 10 Oct 2011 04:00:00 +0100 5362725 http://www.medworm.com/index.php?rid=5598839&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811004968%2Fabstract%3Frss%3Dyes We examined the factors associated with the disruption of yellow plaques among patients and lesion characteristics.Materials and Methods: Consecutive 161 patients with ischemic heart diseases who received coronary angioscopic examination were analyzed. Yellow plaques in the segments to which intervention had never been performed were included, and their yellow color grade and presence/ absence of disruption were examined. Associated factors for plaque disruption were examined among patients and lesion characteristics.Results: In 161 patients, 392 yellow plaques were included for analysis and 70 of them were disrupted. Frequency of plaque disruption (=disrupted / all yellow plaques) was significantly higher at the segments of severer stenosis (stenosis≥75% vs. 75-25% vs. (Source: Thrombos... Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5598839 Wed, 05 Oct 2011 04:00:00 +0100 5598839 http://www.medworm.com/index.php?rid=5545226&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811004907%2Fabstract%3Frss%3Dyes Aging has been associated with an increase in the risk of venous thrombo-embolic events, including deep vein thrombosis and pulmonary embolism. Advanced age leads to a state of hypercoagulability in the blood, raising the relative risk for deep vein thrombosis (DVT) from about 1/10,000 at the age of 40 to 1/100 at the age of 80 . Aging may be associated with an increased prevalence of conventional risk factors, development of new, age-specific risk factors and accumulation of risk factors with age . Immobility, malignancy, co-morbidity, hormone replacement therapy and endothelial dysfunction all contribute to the prothrombotic risk in the elderly, in conjunction with a hypercoagulable state in the plasma . Elevation of the plasma levels of fibrinogen, homocysteine, D-dimers, coagulation fa... Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5545226 Wed, 05 Oct 2011 04:00:00 +0100 5545226 http://www.medworm.com/index.php?rid=5598838&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811004919%2Fabstract%3Frss%3Dyes Abstract: Although it is generally believed that the structure of venous thromboemboli is a homogeneous red blood cell-fibrin clot, their structure may be heterogeneous, with non-uniformly distributed platelet layers, known as the lines of Zahn. We tested (a) whether venous thromboemboli ex vivo contained platelet layers, i.e. the lines of Zahn, and (b) whether, according to mathematical modeling, eddies can arise in the venous system, possibly contributing to platelet aggregation. The structure of venous thromboemboli ex vivo was determined by high-resolution magnetic resonance imaging (MRI) and by immunohistochemistry (IHC). High-resolution ultrasound (US) imaging was employed to determine the popliteal vein geometry and hemodynamics in healthy subjects and in subjects with previous veno... Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5598838 Mon, 03 Oct 2011 04:00:00 +0100 5598838 http://www.medworm.com/index.php?rid=5598851&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811004725%2Fabstract%3Frss%3Dyes Dear Editors, Pseudoprolongation of activated partial thromboplastin time (APTT) occurs in high hematocrit (HCT) samples. In order to correct this problem, a method of Clinical and Laboratory Standards Institute (CLSI) where the amount of anticoagulant (sodium citrate solution) is adjusted according to the HCT of the patient has been reported . However, the CLSI assay needs repeated blood sampling, resulting in time-consuming and complicated procedures. Moreover, there have been serious problems related to blood collection using vacuum blood sample tubes. We previously reported on the usefulness of highly concentrated CaCl2 solution as an APTT assay reagent for high HCT patients using conventional vacuum blood sample tubes . The aim of this study is therefore to investigate whether the AP... Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5598851 Mon, 26 Sep 2011 04:00:00 +0100 5598851 http://www.medworm.com/index.php?rid=5458916&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811004762%2Fabstract%3Frss%3Dyes In this issue, Bucciarelli and colleagues determine if microparticles (MPs) are an independent risk factor for unprovoked venous thromboembolism (VTE) in a case-control study. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5458916 Mon, 26 Sep 2011 04:00:00 +0100 5458916 http://www.medworm.com/index.php?rid=5251573&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811004804%2Fabstract%3Frss%3Dyes (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5251573 Sun, 25 Sep 2011 22:31:36 +0100 5251573 http://www.medworm.com/index.php?rid=5545216&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811004385%2Fabstract%3Frss%3Dyes Abstract: Background: Many markers of platelet activation have been described but their reproducibility and comparability in patient populations are poorly defined.Objectives: We sought to compare markers of platelet and monocyte activation with platelet-monocyte aggregates, a proposed gold standard of in vivo platelet activation, and assess their reproducibility in patients with peripheral arterial disease: a population with substantial platelet activation, inflammation and risk of thrombotic events.Patients/Methods: Thirty patients with peripheral vascular disease attended on two occasions to permit within-day and between-day comparisons. In vivo platelet and monocyte activation were determined by flow-cytometric quantification of platelet-monocyte aggregation, platelet surface expressio... Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5545216 Thu, 22 Sep 2011 04:00:00 +0100 5545216 http://www.medworm.com/index.php?rid=5362729&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811002891%2Fabstract%3Frss%3Dyes In conclusions, we demonstrate that BDNF is released from platelets through predominately PAR1 regulation. Furthermore, we identified two pools of BDNF in the α-granules and cytoplasm of human platelets, and only BDNF in α-granules is released through platelet activation. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5362729 Mon, 19 Sep 2011 04:00:00 +0100 5362729 http://www.medworm.com/index.php?rid=5362719&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811004257%2Fabstract%3Frss%3Dyes Conclusions: Our results indicate that Z4A5 is an effective antithrombotic agent with no significant effects on values of coagulation. Furthermore, Z4A5 can potentiate these antithrombotic effects when prescribed with aspirin. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5362719 Mon, 19 Sep 2011 04:00:00 +0100 5362719 http://www.medworm.com/index.php?rid=5545217&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811004427%2Fabstract%3Frss%3Dyes This study investigated the importance of platelet count, haematocrit, red blood cells (RBC), and white blood cells in whole blood platelet aggregometry.Materials and methods: We included 417 patients with coronary artery disease on aspirin mono-therapy and 21 aspirin-naïve healthy individuals. Blood sampling was performed one hour after aspirin ingestion. The antiplatelet effect of aspirin was evaluated using the VerifyNow® Aspirin assay and multiple electrode aggregometry (MEA, Multiplate®) induced by collagen (1.0μg/mL) and arachidonic acid (1.0 or 0.75mmol/L). Measurements of whole blood parameters were performed to evaluate the three major cell lines in circulating blood.Results: In patients, platelet count correlated significantly with platelet aggregation (MEAcollagen, p (Source... Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5545217 Wed, 14 Sep 2011 04:00:00 +0100 5545217 http://www.medworm.com/index.php?rid=5598846&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811004464%2Fabstract%3Frss%3Dyes Obesity, a health concern of increasing importance in developed countries, is associated with a four- to five-fold increased risk of venous thromboembolism (VTE) in pregnancy . In one study, obese pregnant women were three times more likely to suffer a pulmonary embolism (PE) than a deep vein thrombosis (DVT), placing them at greater risk for mortality than non-obese gravidas . Obesity is also associated with poor pregnancy outcomes, including a 40 percent increased risk for stillbirth compared to non-obese gravidas . (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5598846 Mon, 12 Sep 2011 04:00:00 +0100 5598846 http://www.medworm.com/index.php?rid=5545208&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811004348%2Fabstract%3Frss%3Dyes The objective of the present report is to evaluate the gap between current recommendations/guidelines for stroke/TIA prevention and clinical practice (registry findings). In our opinion new antithrombotic drugs and detailed educational programs (especially devoted to general practitioners and to some medical specialists), concerning efficacy, safety and limitations of these strategies, are needed to better manage stroke epidemics in the third millennium. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5545208 Mon, 12 Sep 2011 04:00:00 +0100 5545208 http://www.medworm.com/index.php?rid=5458940&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811003586%2Fabstract%3Frss%3Dyes In conclusion, IL-18BPa/Fc, via neutralizing the biologic activity of mature IL-18, accelerates lymphocyte apoptosis and downregulates IFN-γ, while permitting the production of Th2 cytokine IL-10. These observations suggest a role of IL-18BPa/Fc in the recovery of Th1/Th2 balance, as well as its therapeutic potential in the treatment of ITP. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5458940 Mon, 12 Sep 2011 04:00:00 +0100 5458940 http://www.medworm.com/index.php?rid=5362710&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811004233%2Fabstract%3Frss%3Dyes Abstract: The protein C anticoagulant pathway plays a crucial role as a regulator of the blood clotting cascade. Protein C is activated on the vascular endothelial cell membrane by the thrombin-thrombomodulin complex. The endothelial protein C receptor binds protein C and further enhances protein C activation. Once formed, activated protein C down-regulates thrombin formation by inactivating factors Va and VIIIa and exerts cytoprotective effects through endothelial protein C receptor binding. An adequate generation of activated protein C depends on the precise assembly, on the surface of the endothelial cells, of thrombin, thrombomodulin, protein C, and endothelial protein C receptor. Therefore, any change in the efficiency of this assembly may cause a reduction or increase in activated pr... Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5362710 Fri, 09 Sep 2011 04:00:00 +0100 5362710 http://www.medworm.com/index.php?rid=5545215&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811004336%2Fabstract%3Frss%3Dyes In conclusion, our data support a role of MIF as an important factor in the regulation of coagulation. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5545215 Wed, 07 Sep 2011 04:00:00 +0100 5545215 http://www.medworm.com/index.php?rid=5458918&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811004294%2Fabstract%3Frss%3Dyes Abstract: Protein Z (PZ) is a vitamin K-dependent factor identified in human plasma in 1984 characterized by an homology with other vitamin K-dependent factors. PZ acts as the cofactor of the PZ dependent inhibitor (ZPI), in the inhibition of activated factor X bound on phospholipid surface. In humans, PZ is characterized by an unusual wide distribution in plasma partly explained by a genetic control. Several PZ gene polymorphisms influencing plasma concentration have been described. In mice, the disruption of PZ gene is asymptomatic, but in association with homozygous FV Leiden produced a severe prothrombotic phenotype. This review analyzes the results obtained from different studies so far published in order to understand whether PZ deficiency could be considered as a risk factor for ven... Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5458918 Thu, 01 Sep 2011 04:00:00 +0100 5458918 http://www.medworm.com/index.php?rid=5362715&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811004142%2Fabstract%3Frss%3Dyes Conclusion: Thromboprophylaxis with enoxaparin in hospitalized medical patients is associated with a lower incidence of VTE and mortality, and is safe. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5362715 Wed, 31 Aug 2011 04:00:00 +0100 5362715 http://www.medworm.com/index.php?rid=5545214&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811004324%2Fabstract%3Frss%3Dyes Conclusion: Tamoxifen increases [Ca2+]i in human platelets by a non-genomic mechanism. Tamoxifen activates phospholipase Cγ as well as PI3-kinase and NADPH oxidase pathway to generate superoxide which causes the release of Ca2+ from the endoplasmic reticulum, and promotes Ca2+ influx into the platelets. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5545214 Mon, 29 Aug 2011 04:00:00 +0100 5545214 http://www.medworm.com/index.php?rid=5458948&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811004245%2Fabstract%3Frss%3Dyes Abstract: Introduction: Fast and accurate monitoring is crucial in the successful regulation of coagulation therapy. For the treatment of venous thromboembolism, both unfractionated heparin (UFH) and low molecular weight heparins (LMWHs) are commonly administered. The chromogenic anti-factor Xa (FXa) assay is currently considered the ‘gold standard’ assay for monitoring LMWH. However different commercial chromogenic methods often differ when tested with the same samples. Fluorogenic anti-FXa assays have the potential to offer greater benefits over chromogenic assays in terms of greater specificity, sensitivity and they are not so influenced by sample opacity or turbidity.Materials and methods: Commercial plasmas were spiked with pharmacologically relevant concentrations (0–1 U/ml) of... Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5458948 Mon, 29 Aug 2011 04:00:00 +0100 5458948 http://www.medworm.com/index.php?rid=5458933&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811004105%2Fabstract%3Frss%3Dyes Thrombotic thrombocytopenic purpura (TTP) is a rare but severe disease characterized by microangiopathic haemolytic anaemia and consumptive thrombocytopenia due to disseminated platelet-rich thrombi in the microcirculation . In up to two thirds of cases TTP is an autoimmune disease caused by the acquired development of autoantibodies against ADAMTS13 (A Disintegrin And Metalloprotease with ThromboSpondin 1 repeats), a metalloprotease that cleaves the platelet-adhesive plasma glycoprotein von Willebrand factor (VWF) Autoantibodies lead to the deficiency of ADAMTS13 activity, that in turns causes the accumulation of uncleaved ultralarge forms of VWF in plasma and microvascular platelet aggregation under circulation conditions of high shear stress . Approximately one third of patients who sur... Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5458933 Mon, 29 Aug 2011 04:00:00 +0100 5458933 http://www.medworm.com/index.php?rid=5458932&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811004063%2Fabstract%3Frss%3Dyes Deep vein thrombosis (DVT) is a serious complication of stroke, which may result in pulmonary embolism (PE) and increase mortality. It occurs in 1-75% of patients, depending on the applied methodology (ranging from clinical symptoms to 125I fibrinogen scanning) . In a recent large clinical trial (n=2518) proximal DVT was diagnosed in 10% of immobile stroke patients allocated to graduated compression stockings (GCS) and 10.5% in the control group . Our study was designed to identify the frequency of DVT in consecutive acute stroke patients and evaluate its impact on outcome. Additionally, we wanted to distinguish between DVT that was certainly developed during the hospital stay and DVT diagnosed early after stroke but most likely being a pre-existing condition. This is the first study addre... Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5458932 Mon, 29 Aug 2011 04:00:00 +0100 5458932 http://www.medworm.com/index.php?rid=5362708&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811004129%2Fabstract%3Frss%3Dyes Protein Z (PZ) is a vitamin K-dependent protein that was identified by Prowse and Esnouf in bovine plasma in 1977 and then isolated from human in 1984 . The organization of molecule structure of PZ was shown to be a homology with other vitamin K-dependent factors like VII, IX, X, protein C. However, it lacks the active center in its amino acid sequence and therefore does not function as a serine protease . PZ plays an important role in regulation of the coagulation pathway, because of the PZ-dependent inactivation of FXa on phospholipid surfaces through the formation of a complex with the Z-dependent protease inhibitor . (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5362708 Thu, 25 Aug 2011 04:00:00 +0100 5362708 http://www.medworm.com/index.php?rid=5545207&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811004208%2Fabstract%3Frss%3Dyes Adenosine diphosphate (ADP)- induced platelet aggregation (PA) is the primary measurement used in clinical studies to evaluate the antithrombotic potency of clopidogrel and other P2Y12 receptor blockers and has been supported by evidence correlating high on-treatment PA with post-percutaneous coronary intervention (PCI) ischemic event occurrence . However, there is discordance between the low frequency of ischemic event occurrence and the high frequency of patients deemed “resistant” by this measurement which is particularly evident in studies demonstrating a very early clinical effect of clopidogrel loading when inhibition of platelet aggregation is sub-maximal . P2Y12 receptor-mediated platelet activation plays a key role in coagulation factor (thrombin) generation by directly modula... Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5545207 Wed, 24 Aug 2011 04:00:00 +0100 5545207 http://www.medworm.com/index.php?rid=5458942&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811004002%2Fabstract%3Frss%3Dyes Abstract: Introduction: Carriers of reduced-function CYP2C19 allele on antiplatelet therapy show diminished platelet inhibition and higher rate of clinical risk. The purpose of this study was to determine cut-off levels of VerifyNow P2Y12 system associated with effective inhibition of on-clopidogrel platelet aggregation to predict carriers of CYP2C19 reduced-function allele among patients undergoing percutaneous coronary intervention (PCI).Materials and Methods: We enrolled 202 consecutive patients with stable coronary artery disease (CAD) undergoing PCI and treated with clopidogrel. All patients underwent CYP2C19 genotyping and measurement of residual platelet aggregation by VerifyNow system.Results: Carriers of CYP2C19 reduced-function allele constituted 131 (65%) of 202 CAD patients. Pl... Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5458942 Wed, 24 Aug 2011 04:00:00 +0100 5458942 http://www.medworm.com/index.php?rid=5362737&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811003537%2Fabstract%3Frss%3Dyes Conclusions: Reduction of monocyte- and supernatant-associated procoagulant activity by glibenclamide is associated with decreased expression of TF and asTF and possibly with a reduced MP number. Our data indicate that glibenclamide reduces the prothrombotic state in LPS-stimulated monocytes in vitro. Glibenclamide might therefore also have an anticoagulant effect in vivo, but this needs to be further evaluated. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5362737 Wed, 24 Aug 2011 04:00:00 +0100 5362737 http://www.medworm.com/index.php?rid=5145042&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS004938481100394X%2Fabstract%3Frss%3Dyes (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5145042 Sat, 20 Aug 2011 17:07:46 +0100 5145042 http://www.medworm.com/index.php?rid=5545213&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811003501%2Fabstract%3Frss%3Dyes Conclusions: The SDTINR is a better predictor of mortality, stroke, bleeding and hospitalisation than the TTR in patients with atrial fibrillation receiving warfarin therapy. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5545213 Thu, 18 Aug 2011 04:00:00 +0100 5545213 http://www.medworm.com/index.php?rid=5458947&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811004166%2Fabstract%3Frss%3Dyes Conclusion: These data suggest that UFH attenuates inflammation and coagulation and prevents lethality in endotoxemic mice. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5458947 Thu, 18 Aug 2011 04:00:00 +0100 5458947 http://www.medworm.com/index.php?rid=5458944&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811004178%2Fabstract%3Frss%3Dyes Conclusions: CTEPH was found to be a frequent sequela in patients with recurrent PE. The prevalence of CTEPH is dependent on the patient's functional class. Evaluation for PH might be useful in symptomatic patients after recurrent PE. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5458944 Thu, 18 Aug 2011 04:00:00 +0100 5458944 http://www.medworm.com/index.php?rid=5545212&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811003422%2Fabstract%3Frss%3Dyes Conclusions: The risk score model applied proved effective in avoiding pharmacological prophylaxis in almost half of women and safe, since the rate of failure resulted very low (0.2%, C.I.95 0–1.1%) and there were not significant differences in bleeding in the two groups. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5545212 Tue, 16 Aug 2011 04:00:00 +0100 5545212 http://www.medworm.com/index.php?rid=5458926&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811004038%2Fabstract%3Frss%3Dyes Conclusions: We demonstrate morphologically that H12-liposomes bind to thrombin-activated platelets and accumulate between adherent platelets like fibrinogen, leading to large-scale aggregation. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5458926 Tue, 16 Aug 2011 04:00:00 +0100 5458926 http://www.medworm.com/index.php?rid=5251576&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811003380%2Fabstract%3Frss%3Dyes Abstract: Carotid artery dissections are the second leading cause of stroke in young adults. The hemostatic response to a dissection involves exposure of the subendothelium to the intravascular environment. Platelet activation/aggregation superimposed by secondary coagulation cascade activity attempts to heal the injury. Failure of the hemostatic response to heal the injury may lead to further rupture of the intimal and medial layers, which allows for the blood to penetrate these layers to create a false lumen. Continued hemorrhaging into the false lumen may result in dissection progression or obstruction of blood supply to the true lumen and downstream blood vessels. The effects of thrombosis in the true versus false lumen may lead to opposite consequences. True lumen clotting may lead to... Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5251576 Tue, 16 Aug 2011 04:00:00 +0100 5251576 http://www.medworm.com/index.php?rid=5458943&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811004026%2Fabstract%3Frss%3Dyes Abstract: Pulmonary embolism development may be prevented if asymptomatic venous thromboembolism (VTE) can be predicted and treated preoperatively or soon after total knee arthroplasty (TKA). The purpose of this study was to evaluate whether asymptomatic VTE can be predicted by blood coagulation markers preoperatively or early after TKA. This prospective single-centre study enrolled 68 patients (6 men, 62 women; mean age: 71years) who underwent TKA between September 2004 and August 2009. Sixteen-row multidetector computed tomography was performed 4days before and after surgery for diagnosis of asymptomatic VTE. Blood samples were taken to measure the plasma levels of soluble fibrin monomer complex (SFMC), D-dimer and cross-linked fibrin degradation products by leukocyte elastase (e-XDP) at... Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5458943 Fri, 12 Aug 2011 04:00:00 +0100 5458943 http://www.medworm.com/index.php?rid=5362709&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811003604%2Fabstract%3Frss%3Dyes Conclusion: FVL plays a role in IBD-TE, but to no greater extent than it does in the general population with TE. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5362709 Wed, 10 Aug 2011 04:00:00 +0100 5362709 http://www.medworm.com/index.php?rid=5598837&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811003690%2Fabstract%3Frss%3Dyes Abstract: The endothelial protein C receptor (EPCR) plays a crucial role in the anticoagulant and anti-inflammatory effects of the protein C pathway, whereas its soluble form (sEPCR) exhibits opposite properties. High plasma levels of sEPCR have been observed in subjects carrying the A3 haplotype of PROCR, the EPCR gene. Elevated plasma levels of sEPCR were also recently reported in women with preeclampsia (PE), a multisystemic syndrome involving inflammation, endothelial dysfunction and thrombosis. To determine whether this increase is genetically mediated or acquired, we analyzed sEPCR levels and the A3 haplotype distribution in 145 preeclamptic women and 145 age- and term-matched women with normal pregnancies enrolled in a case-control study. Plasma sEPCR levels were higher in the women... Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5598837 Tue, 09 Aug 2011 04:00:00 +0100 5598837 http://www.medworm.com/index.php?rid=5458941&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811003574%2Fabstract%3Frss%3Dyes Abstract: Introduction: Low molecular weight heparins (LMWHs) are used worldwide for the treatment and prophylaxis of thromboembolic disorders. Routine laboratory tests are not required due to the predictable pharmacokinetics of LMWHs, with the exception of pregnant patients, children, patients with renal failure, morbid obesity, or advanced age. Anti-Factor Xa (anti-FXa) plasma levels are most often employed in the assessment and guidance of accurate dosing in these patient cohorts.Materials and methods: A LMWH calibration curve was generated using citrated human pooled plasma spiked with pharmacologically relevant concentrations (0–1.2U/ml) of two low molecular weight heparins; enoxaparin and tinzaparin. Least squares analysis determined the best curve fit for this set of data which re... Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5458941 Tue, 09 Aug 2011 04:00:00 +0100 5458941 http://www.medworm.com/index.php?rid=5598850&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811003641%2Fabstract%3Frss%3Dyes All-trans retinoic acid (ATRA) has proven to be a major advance in the management of patients with acute promyelocytic leukemia (APL). Several studies show that treatment regimens containing ATRA for remission induction followed by several cycles of cytotoxic chemotherapy for consolidation yield overall survival rates superior to those produced by chemotherapy alone . However, when APL relapses in patients who have received ATRA-containing regimens, few of them respond to ATRA alone . (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5598850 Mon, 08 Aug 2011 04:00:00 +0100 5598850 http://www.medworm.com/index.php?rid=5458946&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811003732%2Fabstract%3Frss%3Dyes Abstract: Bone morphogenetic protein (BMP)-7 regulates atherosclerotic plaque calcification, and it contributes to increased thrombogenicity of lipid-rich lesions by enhancement of TF expression in monocytes/macrophages by unknown mechanism. Since Erk1/2, JNK and p38 mitogen activated protein kinases (MAPKs) regulate TF expression, we studied involvement of MAPK pathways in BMP-7-induced activation of TF in human mononuclear cells (MNCs). Whole blood from healthy volunteers was treated with BMP-7, MNCs were isolated, and TF expression was assessed by western blot (WB) and In-Cell Western assay. Phosphorylation and nuclear translocation of Smad1/5/8 in response to BMP-7 stimulation of MNCs was evaluated by WB and confocal microscopy. Activation of MAPKs was judged by measuring the levels of... Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5458946 Mon, 08 Aug 2011 04:00:00 +0100 5458946 http://www.medworm.com/index.php?rid=5458939&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811003598%2Fabstract%3Frss%3Dyes Conclusions: Acute-onset AF activates platelets within minutes to initiate platelet-MNC interaction. The subsequent platelet binding induced TF expression in patients with chronic AF. These findings support the efficacy of anticoagulant therapeutics in chronic AF and suggest the underlying utility of antiplatelet therapeutics in early phase of AF occurrence. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5458939 Mon, 08 Aug 2011 04:00:00 +0100 5458939 http://www.medworm.com/index.php?rid=5362730&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811002970%2Fabstract%3Frss%3Dyes Abstract: Background: Elevated factor (F)XI is associated with an increased risk for ischemic stroke. Activated FXI (FXIa) and tissue factor (TF) have not been studied following stroke. The aim of the current study was to evaluate circulating FXIa and TF in patients with prior cerebrovascular events.Patients/Methods: We studied 241 patients, including 162 after ischemic stroke and 79 after transient ischemic attack (TIA), recruited 6months to 4years (median, 36months) after the events. Plasma TF and FXIa activity following the index event were determined in clotting assays by measuring the response to inhibitory monoclonal antibodies.Results: Active TF was detected in 25 (10.4%) of the patients, while FXIa activity (median, 37.5 [IQR 397] pM) was found in 64 (26.7%) of the patients (p (Sou... Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5362730 Mon, 08 Aug 2011 04:00:00 +0100 5362730 http://www.medworm.com/index.php?rid=5362728&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811003045%2Fabstract%3Frss%3Dyes Bleeding events are the most relevant complications during oral anticoagulant treatment (OAT). They have been reported to occur at a rate of about 1.35 cases each 100 patients/year . In very rare instances, OAT-related bleeding in patients with INR values within the therapeutic range may be associated with a mutation of the factor IX (FIX) gene. Two propeptide mutations have been described at locus-10: Ala (GCC)-10 Val (GTC) and Ala (GCC)-10 Thr (ACC) . The propeptide sequence at locus-10 plays an important role in the anticoagulant effect of vitamin K antagonists (VKA), since it contains the hepatic γ-carboxylase binding site . In the presence of a propeptide locus-10 mutation, hepatic γ-carboxylase binding to the FIX protein is markedly reduced. This reduced binding capacity has no cli... Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5362728 Mon, 08 Aug 2011 04:00:00 +0100 5362728 http://www.medworm.com/index.php?rid=5598835&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS004938481100363X%2Fabstract%3Frss%3Dyes Conclusions: Physicians who are regular prescribers of VTE prophylaxis underestimate patients’ ability to accept injectable treatments as an alternative to oral therapy. This survey suggests that injectable treatments may be an acceptable, and often preferred, option over oral administration of therapeutic and preventive medicines. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5598835 Thu, 04 Aug 2011 04:00:00 +0100 5598835 http://www.medworm.com/index.php?rid=5458935&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811003562%2Fabstract%3Frss%3Dyes Glycoprotein (GP) IIb/IIIa is a platelet receptor with a regulatory function involved in the final step of platelet-mediated thrombus formation at the site of vessel injury . It binds to fibrinogen and von Willebrand factor (vWF), causing platelet aggregation . The glycoprotein IIb/IIIa receptor consists of a 2-chain glycoprotein IIb subunit non-covalently associated with a single-chain glycoprotein IIIa subunit. Platelet aggregation is particularly active at sites of eroded or ruptured coronary atherosclerotic plaques that underlie unstable angina and myocardial infarction (MI) and of endothelial disruption associated with coronary artery disease. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5458935 Thu, 04 Aug 2011 04:00:00 +0100 5458935 http://www.medworm.com/index.php?rid=5362738&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811003628%2Fabstract%3Frss%3Dyes Conclusions: This meta-analysis indicated that LPL Ser447Ter polymorphism was associated with a significant reduction in the risk of ischemic stroke, especially atherosclerotic stroke subtype in both Caucasian and East-Asian. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5362738 Thu, 04 Aug 2011 04:00:00 +0100 5362738 http://www.medworm.com/index.php?rid=5362735&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811003525%2Fabstract%3Frss%3Dyes Conclusions: Following mechanical valve replacement, combined low dose aspirin and warfarin therapy was associated with a greater reduction in thromboembolism events than warfarin therapy alone. This combined treatment was not associated with an increase in the rate of major bleeding or mortality. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5362735 Thu, 04 Aug 2011 04:00:00 +0100 5362735 http://www.medworm.com/index.php?rid=5362724&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811003719%2Fabstract%3Frss%3Dyes This study is very important for determination of normal range of MPV in control subjects. They also excluded the associated conditions those can increase or influence MPV like smoking, diabetes, hypertension, coronary artery disease, hyperlipidemia, chronic obstructive lung disease, malignency, antiplatelet drugs use, heavy drinkers, metabolic syndrome, heart failure, renal and hepatic failure and thyroid function disorder. However, we think there are several important points those must be concerned. Firstly, as we understand from study, the control subjects included in the study were living in the Duzce city for a long time. Recently, Alper et al. compared the MPV and platelet counts in patients who experienced an acute coronary event at moderately high altitude and at sea altitude and t... Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5362724 Wed, 03 Aug 2011 04:00:00 +0100 5362724 http://www.medworm.com/index.php?rid=5598836&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811003707%2Fabstract%3Frss%3Dyes Conclusion: The administration of PCC for the emergency reversal of warfarin may be associated with a low risk of thromboembolism. The contribution of an unmasked thrombotic process by cessation of anticoagulation or of activation of coagulation by the hemorrhagic event should also be considered. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5598836 Tue, 02 Aug 2011 04:00:00 +0100 5598836 http://www.medworm.com/index.php?rid=5458945&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811003616%2Fabstract%3Frss%3Dyes Abstract: Hemophilia A is an X-linked recessive bleeding disorder, widely prevalent throughout the world, for which, replacement therapy is the current treatment done by infusion of either recombinant FVIII or human plasma derived FVIII. The expression of FVIII is limited by many aspects, bioengineered FVIII with increased the activity and/or the stability can overcome some of these limitations. We demonstrate that a furin cleavage site (RKRR) and a 2A self-processing peptide derived from FMDV can efficiently and apparently facilitate the equimolar expression of full-length FVIII heavy and light chains from a single ORF, and the FVIII heavy and light chain can self-assemble to form a functional molecule in vivo and in vitro. In addition, our results shown that retaining the 6 N-linked olig... Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5458945 Tue, 02 Aug 2011 04:00:00 +0100 5458945 http://www.medworm.com/index.php?rid=5598834&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811003471%2Fabstract%3Frss%3Dyes Conclusions: Moderate hyperhomocysteinemia or elevated Lp(a) level associated with a risk of CAD and MI only in women. While isolated elevation of one of the two parameters represented a mild risk of CAD, their combined elevation highly increased the risk in females. No such effect was observed in males. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5598834 Mon, 01 Aug 2011 04:00:00 +0100 5598834 http://www.medworm.com/index.php?rid=5545211&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811003392%2Fabstract%3Frss%3Dyes Conclusions: FDG-PET/CT may have utility for excluding occult malignancy in patients with unprovoked VTE. The costs of this comprehensive screening strategy were comparable to other screening approaches. Larger studies are needed to further evaluate the utility and cost-effectiveness of FDG-PET/CT as a cancer screening strategy in patients with unprovoked VTE. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5545211 Mon, 01 Aug 2011 04:00:00 +0100 5545211 http://www.medworm.com/index.php?rid=5458938&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811003550%2Fabstract%3Frss%3Dyes A new missense mutation in exon 8 of the F9 gene that results in a substitution of an arginine to a leucine at position 338 (R338L) was described by Simioni et al. . This mutation, called factor IX Padua, was discovered in a 23year-old man presenting with a spontaneous venous thromboembolism (VTE). Established genetic risk factors for VTE were not present in this patient. The patient had a normal factor IX antigen level but his factor IX activity level was approximately eight times the normal level. Factor IX Padua was shown to be a gain-of-function mutation resulting in an elevation of the factor IX activity. Screening for the factor IX Padua mutation in 200 controls and 200 patients with a documented VTE and normal factor IX activity levels resulted in no additional cases. Factor IX Padu... Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5458938 Mon, 01 Aug 2011 04:00:00 +0100 5458938 http://www.medworm.com/index.php?rid=5458937&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811003513%2Fabstract%3Frss%3Dyes We read with interest the article by Andersson et al. on the predictive value of plasminogen activator inhibitor-1 (PAI-1) mass on maintenance of sinus rhythm after electrical cardioversion (EC) in atrial fibrillation (AF) . Sinus rhythm maintenance after EC is challenging, given that vascular injury and a pro-inflammatory state exists in AF, and may perhaps be increased after EC. Indeed, these have been proposed as major contributors of AF recurrence, as a consequence of disruption of vascular homeostasis . (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5458937 Mon, 01 Aug 2011 04:00:00 +0100 5458937 http://www.medworm.com/index.php?rid=5362736&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811003549%2Fabstract%3Frss%3Dyes This study attempts to determine whether serum or tissue Hc in patients undergoing surgery for AAAs is associated with aneurysm diameter, circulating and tissue levels of MMP-3 and MMP-9 assessed by Enzyme-linked immunosorbent assay (ELISA) and their mRNA tissue expression assessed by real-time PCR. Twenty-seven patients were recruited in the study.Results: Forty-three percent of the patients had abnormal Hc serum levels (>35.9μmol/L). Circulating MMP-3 (6.44±4.20ng/mL) and MMP-9 levels (134±11.4ng/mL) were elevated compared to healthy controls (p (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5362736 Mon, 01 Aug 2011 04:00:00 +0100 5362736 http://www.medworm.com/index.php?rid=5598844&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811003057%2Fabstract%3Frss%3Dyes Conclusions: This is the first study to investigate the relationship between varying levels of FVL and plasma derived MP. These results are consistent with our previous findings of an increase in MP levels in carriers of FVL as compared to controls, and suggest a role for FVL/FV ratio in predicting risk of thrombosis in carriers of FVL. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5598844 Thu, 28 Jul 2011 04:00:00 +0100 5598844 http://www.medworm.com/index.php?rid=5458934&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811003495%2Fabstract%3Frss%3Dyes With clopidogrel treatment after acute coronary syndrome or percutaneous coronary intervention (PCI), or both, the presence of any loss-of-function cytochrome P450 2C19 (CYP2C19) allele (*2, *3, *4, *5, *6, *7, or *8) is associated with reduced concentrations of active drug metabolite and diminished platelet inhibition, whereas the presence of the gain-of-function CYP2C19 allele (*17) is associated with enhanced response to clopidogrel . Yet, consensus is lacking on whether the diminished or enhanced pharmacologic responses translate into worse or better clinical outcomes and whether the proposed increased or reduced risks of major adverse cardiovascular events (MACE) are associated with 2 mutant CYP2C19 alleles or just 1. Therefore, we performed a meta-analysis to address these issues. (S... Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5458934 Thu, 28 Jul 2011 04:00:00 +0100 5458934 http://www.medworm.com/index.php?rid=5458921&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811002878%2Fabstract%3Frss%3Dyes Conclusions: The incidence of thrombotic events was low in both groups. There were no safety concerns, and desirudin was not associated with anti-PF4/heparin antibodies. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5458921 Wed, 27 Jul 2011 04:00:00 +0100 5458921 http://www.medworm.com/index.php?rid=5362734&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS004938481100346X%2Fabstract%3Frss%3Dyes This study suggests that the secretion level of IFN-γ and/or LT-α could be a predictive marker of prednisone responsiveness. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5362734 Tue, 26 Jul 2011 04:00:00 +0100 5362734 http://www.medworm.com/index.php?rid=5362732&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811003033%2Fabstract%3Frss%3Dyes Abstract: Objectives: Platelet-leukocyte aggregation is believed to contribute to acute thrombotic events. While the effect of aspirin on platelet-to-platelet aggregation is well established, the impact of the drug on pro-inflammatory platelet function remains equivocal. Thus we investigated the effect of aspirin on selected platelet-related inflammatory biomarkers in both acute ischaemic stroke patients and healthy volunteers.Methods: Using five-colour flow cytometry the platelet surface expression of CD62P and CD40L and subpopulations of leukocyte-platelet aggregates were assessed in 63 acute stroke patients and 40 healthy volunteers at baseline and after a 10-day period of aspirin intake at a daily dose of 150mg. Simultaneously the plasma levels of soluble CD62P and CD40L, serum level o... Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5362732 Tue, 26 Jul 2011 04:00:00 +0100 5362732 http://www.medworm.com/index.php?rid=5362727&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811003021%2Fabstract%3Frss%3Dyes Hereditary free protein S (FPS) deficiency is a well-known risk factor for venous thrombosis (VT) . Acquired FPS deficiency has been reported during pregnancy , in the nephrotic syndrome , in auto-immune disorders , and in infections such as human immunodeficiency virus . The mechanism by which FPS levels are lowered in these diseases is supposed to be by increase of complement 4 binding protein (C4BP) due to the acute phase. However, this hypothesis is challenged. Whether acquired FPS deficiency increases risk of VT is unknown. Recently, we found that FPS levels below 41IU/dL can identify subjects at risk of VT . We performed a case-control study to determine whether FPS levels below 41IU/dL are also associated with an increased risk of VT in the acute moment, as well as to assess the eff... Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5362727 Thu, 21 Jul 2011 04:00:00 +0100 5362727 http://www.medworm.com/index.php?rid=5362718&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811003434%2Fabstract%3Frss%3Dyes Abstract: Introduction: Concerns have been raised about the potential adverse interaction between clopidogrel and PPIs. We studied the impact of esomeprazole and ranitidine on the antiplatelet action of clopidogrel and aspirin and sought to determine whether doubling the dose of clopidogrel could restore its efficacy.Materials and methods: In a randomized prospective crossover study, we tested platelet reactivity to aspirin and clopidogrel (75 and 150mg) with and without esomeprazole or ranitidine using the VerifyNow system (Accumetrics Inc, San Diego, CA, USA) in 4 stages, each lasting 7days: T1, 160mg aspirin and 75mg clopidogrel; T2 : 160mg aspirin+75mg clopidogrel+20mg esomeprazole, T3 : 160mg aspirin+150mg clopidogrel+20mg esomeprazole and T4 : 160mg aspirin+75mg clopidogrel+150mg ran... Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5362718 Thu, 21 Jul 2011 04:00:00 +0100 5362718 http://www.medworm.com/index.php?rid=5040860&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811003264%2Fabstract%3Frss%3Dyes (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5040860 Wed, 20 Jul 2011 18:41:31 +0100 5040860 http://www.medworm.com/index.php?rid=5362726&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811002994%2Fabstract%3Frss%3Dyes Protein S (PS) is a vitamin K-dependent glycoprotein with a molecular mass of about 78kDa. The human PS gene, PROS1, is located on chromosome 3q11.2, where it spans 80kb of genomic DNA and contains 14 introns and 15 exons . The protein functions as a cofactor for activated protein C (APC), an anticoagulant serine protease, which regulates blood coagulation by inactivating factors Va and VIIIa . PS is found in plasma both in a free form (30%) and complexed with C4b-binding (C4BP) protein . Recently, it has been described that not only the free form but both forms work as cofactors for activated protein C . Certain mutations in this gene result in autosomal dominant hereditary thrombophilia. PS deficiency affects up to 2% of families with congenital thrombophilia . (Source: Thrombosis Resear... Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5362726 Mon, 18 Jul 2011 04:00:00 +0100 5362726 http://www.medworm.com/index.php?rid=5598845&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811003367%2Fabstract%3Frss%3Dyes Conclusion: Treatment of THP-1 cells with anthracyclines induces apoptosis and increases cellular TF activity. The increased activity required an increase in exposure of PS. Additionally, anthracyclines increase the release of TF-positive MPs from THP-1 cells. We propose that the increase in cellular TF activity in circulating leukemic cells, combined with increased numbers of TF-positive MPs, may contribute to thrombosis in cancer patients receiving chemotherapy. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5598845 Fri, 15 Jul 2011 04:00:00 +0100 5598845 http://www.medworm.com/index.php?rid=5458936&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811003379%2Fabstract%3Frss%3Dyes The laboratory criteria for the antiphospholipid syndrome (APS) include lupus anticoagulants (LAC), medium or high titer (>40 GPL or MPL, or >99th percentile) anticardiolipin antibodies (aCL) or anti-β2-glycoprotein I antibodies (aβ2GPI) (>99th percentile) . aCL and aβ2GPI should be measured by standardized enzyme-linked immunosorbent assays (ELISA) following recommended procedures . Coagulation assays for LAC as well as ELISAs for the detection of antiphospholipid antibodies antibodies (aPL) show methodological shortcomings . In spite of tremendous efforts, standardization has not been achieved and continues to be a topic of discussion and concern to scientists, laboratory workers and clinicians; especially for the solid phase assays, since progress has been made in the detection of LA... Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5458936 Fri, 15 Jul 2011 04:00:00 +0100 5458936 http://www.medworm.com/index.php?rid=5362733&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811003331%2Fabstract%3Frss%3Dyes We examined the effect of the PPARγ agonist rosiglitazone on the expression of plasminogen activator inhibitor-1 (PAI-1) that is the primary inhibitor of fibrinolysis in the liver of diabetic mice and cultured mouse and human hepatocytes. Concentrations of plasma PAI-1 and levels of its mRNA expression in the liver were significantly elevated in accordance with hepatic PPARγ1 and PPARγ2 mRNA accumulation in genetically diabetic db/db mice. An intraperitoneal injection of rosiglitazone significantly increased plasma PAI-1 concentrations in parallel with hepatic, but not with adipose mRNA levels in db/db mice, and did not affect these parameters in wild-type mice. Rosiglitazone as well as the PPARα agonist bezafibrate significantly induced PAI-1 mRNA expression in cultured mouse hepatocy... Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5362733 Fri, 15 Jul 2011 04:00:00 +0100 5362733 http://www.medworm.com/index.php?rid=5362717&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811002982%2Fabstract%3Frss%3Dyes Conclusions: Our results provide strong evidence that lumican affects angiogenesis both by interfering with α2β1 receptor activity and downregulating proteolytic activity associated with surface membranes of endothelial cells. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5362717 Fri, 15 Jul 2011 04:00:00 +0100 5362717 http://www.medworm.com/index.php?rid=5251600&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811003355%2Fabstract%3Frss%3Dyes Conclusions: Our data suggests that the presence of thrombospondin-1 (rs2228262) and thrombospondin-2 (rs8089) variants need not be considered a risk for coronary artery disease or myocardial infarction among South Indians. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5251600 Fri, 15 Jul 2011 04:00:00 +0100 5251600 http://www.medworm.com/index.php?rid=5251589&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811002921%2Fabstract%3Frss%3Dyes Venous thromboembolism (VTE) is an important clinical problem with an incidence of 1–2 per 1000 persons and the consequences can be life-threatening . Although the causes are not always identified, it is believed that increasing hypercoagulability can alter the balance of hemostasis, explaining the occurrence of VTE in apparently healthy individuals . Hypercoagulability may be due to defective naturally occurring anticoagulant mechanisms or to heightened levels of procoagulant factor . These factors belong to the clinical intrinsic pathway of blood coagulation, which is cumulatively monitored by the coagulation and activated partial thromboplastin time (APTT) tests . (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5251589 Fri, 15 Jul 2011 04:00:00 +0100 5251589 http://www.medworm.com/index.php?rid=5145043&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811003343%2Fabstract%3Frss%3Dyes Neutrophil elastase (NE) is an abundant serine proteinase stored in the azurophilic granules of neutrophils along with cathepsin G (CathG) and proteinase-3 (PR3). Elevated serum levels or overexpression of these proteinases has been reported in cases of severe inflammations such as sepsis, autoimmune diseases, etc . NE is released to the circulation upon activation of neutrophil by inflammatory factors, such as, lipopolysaccharide (LPS) and inflammatory cytokines, tumor necrosis factor and interleukin-1, 6 and 8, etc. These proteinases are considered to work for host defense by killing bacteria associated with infectious diseases . However, the excess release of NE from activated neutrophil in severe sepsis mediates tissue damage through the proteolyitc cleavage of cell surface glycoprotei... Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5145043 Thu, 14 Jul 2011 23:00:00 +0100 5145043 http://www.medworm.com/index.php?rid=5598843&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811002945%2Fabstract%3Frss%3Dyes Conclusion: The potential calibrators were commutable. Limited harmonization was achieved by using a common calibrator for all participants. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5598843 Mon, 11 Jul 2011 04:00:00 +0100 5598843 http://www.medworm.com/index.php?rid=5545210&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811002957%2Fabstract%3Frss%3Dyes Conclusions: Fondaparinux was well tolerated and was safe in prophylaxis and therapy; prescriptions mostly followed the current approval guidelines and were rarely related to HIT-associated indications (94% of prescriptions were HIT-associated). A trend towards an individualised fondaparinux use based on the compound's inherent properties and the patients’ risk profiles, i.e., antecedent HIT, bone fractures, heparin allergy, was observed. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5545210 Fri, 08 Jul 2011 04:00:00 +0100 5545210 http://www.medworm.com/index.php?rid=5458924&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811002969%2Fabstract%3Frss%3Dyes Conclusions: Despite the retrospective nature of this study, our findings suggest that the incidence of hemorrhagic complications increases in patients with acute ischemic stroke treated with combination antiplatelet agents. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5458924 Fri, 08 Jul 2011 04:00:00 +0100 5458924 http://www.medworm.com/index.php?rid=5458923&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811002908%2Fabstract%3Frss%3Dyes Conclusions: In this exploratory study, gene expression profiles of whole blood appear to be a useful strategy to distinguish subjects with single venous thromboembolism from those with recurrent venous thromboembolism. Prospective studies with additional patients are needed to validate these results.Research Highlights: ► D-dimer levels are higher in patients with recurrent VTE. ► Expression profiles distinguish patients with 1 event from those with recurrent VTE. ► The Akt pathway is up-regulated in patients with recurrent VTE. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5458923 Fri, 08 Jul 2011 04:00:00 +0100 5458923 http://www.medworm.com/index.php?rid=5545221&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS004938481100291X%2Fabstract%3Frss%3Dyes Conclusion: TF+ MPs can be quantitatively isolated from platelet poor or platelet free plasma by centrifugation at 20,000×g for 15minutes. Measurement of MP TF activity in plasma may be used to detect a prothrombotic state in patients with various diseases. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5545221 Thu, 07 Jul 2011 04:00:00 +0100 5545221 http://www.medworm.com/index.php?rid=5458922&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811002866%2Fabstract%3Frss%3Dyes Conclusions: The results of this pilot study do not support the concern that thrombophilia screening in asymptomatic relatives triggers psychological distress and worry. Furthermore, our intensive educational approach did not appear to induce undue distress. While the positive benefits of thrombophilia screening remain unproven, clinicians should not be deterred from offering screening by the fear of causing psychological harm.Research highlights: ► Psychological distress is not common following thrombophilia testing of relatives. ► Any negative psychological response to thrombophilia screening is short-lived. ► An Intensive Care strategy did not increase worry or distress for thrombophilic FDRs. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5458922 Thu, 07 Jul 2011 04:00:00 +0100 5458922 http://www.medworm.com/index.php?rid=5362731&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811003008%2Fabstract%3Frss%3Dyes In conclusion: OC use increases the plasma measures of FSAP. The increase in FSAP is comparable in the seven OC-groups studied but is more significant in women carrying the 1601GG genotype than in women with the 1601GA genotype and results in increased activation of FVII suggesting that FSAP-induced activation of FVII takes place in-vivo and not only in-vitro as hitherto described. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5362731 Thu, 07 Jul 2011 04:00:00 +0100 5362731 http://www.medworm.com/index.php?rid=5251590&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811002933%2Fabstract%3Frss%3Dyes The antiplatelet activity of some flavonoids partly explains its protecting role on the cardiovascular system, but concomitant use of herbal medicines with conventional drugs could cause pharmacological interactions that need to be clarified in the clinical setting for patient's safety, especially in coronary patients under antiplatelet therapy. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5251590 Thu, 07 Jul 2011 04:00:00 +0100 5251590 http://www.medworm.com/index.php?rid=5251574&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS004938481100301X%2Fabstract%3Frss%3Dyes Atrial fibrillation (AF), is the most common cardiac arrhythmia causing significant morbidity and mortality, especially among the aged population . The annual rate of thromboembolic (TE) events in patients with AF is 5% compared to 0.5-1% in age-matched controls without AF . The risk of TE increases in the presence of known clinical factors and it can be predicted by risk assessment models such as the CHADS2 and more recently, by CHAD-VASc score. A score of≥1 by CHAD-VASc requires anticoagulation with vitamin K antagonists (VKA) which can effectively reduce the risk of TE . However, in older patients, while the risk of TE decreases with anticoagulant (AC) treatment, the hemorrhage risk intensifies . (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5251574 Thu, 07 Jul 2011 04:00:00 +0100 5251574 http://www.medworm.com/index.php?rid=5458925&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS004938481100288X%2Fabstract%3Frss%3Dyes Conclusions: Serotonin level was higher in patients with MVD than in those with SVD (p (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5458925 Mon, 04 Jul 2011 04:00:00 +0100 5458925 http://www.medworm.com/index.php?rid=5251588&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811002842%2Fabstract%3Frss%3Dyes Cardiac Resynchronization Therapy (CRT) leads to a reduction of left-ventricular dyssynchrony, with an acute and sustained hemodynamic improvement in patients with systolic heart failure, with reverse remodeling of the left ventricle . This leads to an improvement in functional capacity, clinical status and quality of life . In addition, CRT reduces mortality from progressive heart failure, as well as heart failure hospitalization . Unfortunately, ‘non-responders’ to CRT are an evident problem, and there is the need for appropriate biomarkers to identify such patients. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5251588 Tue, 28 Jun 2011 04:00:00 +0100 5251588 http://www.medworm.com/index.php?rid=5251598&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811002817%2Fabstract%3Frss%3Dyes Conclusions: Preeclampsia by itself may be responsible for the increase in TAFIa values rather than the presence of polymorphisms. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5251598 Mon, 27 Jun 2011 04:00:00 +0100 5251598 http://www.medworm.com/index.php?rid=5145062&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811002829%2Fabstract%3Frss%3Dyes There are only few publications on the role and the possible clinical relevance of the inhibition of factor VIIa (FVIIa) by antithrombin (AT), a major plasma inhibitor of many coagulation proteases . It has been shown in previous in vitro studies that AT inactivates FVIIa only when FVIIa is bound to tissue factor (TF) . As a result, FVIIa-AT complex (FVIIa-AT) plasma levels have the potential to reflect the degree of intravascular exposure of TF to the blood . Recently, we assessed plasma levels of the FVIIa-AT in adults with arterial and venous thrombosis . We found that individuals with a previous thrombotic event had significantly higher levels of FVIIa-AT than either normal controls or patients with acute thrombosis. In contrast, those with acute arterial or venous events had lower FVI... Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5145062 Sun, 26 Jun 2011 23:00:00 +0100 5145062 http://www.medworm.com/index.php?rid=5545220&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811002854%2Fabstract%3Frss%3Dyes Abstract: To evaluate associations between adiposity and coagulation or inflammation profile, obese wild-type C57Bl/6 mice were subjected to drastic caloric restriction by switching from a high fat diet to restricted normal chow. After 6weeks, total body weights as well as subcutaneous and gonadal adipose tissue mass were markedly reduced, associated with adipocyte hypotrophy (all p (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5545220 Tue, 21 Jun 2011 04:00:00 +0100 5545220 http://www.medworm.com/index.php?rid=5362714&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811002830%2Fabstract%3Frss%3Dyes Abstract: Introduction: Therapeutic (international normalized ratio, INR 2.0-3.5) oral anticoagulation (TOAC) is assumed to increase perioperative bleeding complications and a standard recommendation is to discontinue warfarin before coronary bypass grafting (CABG).Materials and Methods: To assess the safety of TOAC we retrospectively analyzed consecutive patients (n=270) with long-term warfarin therapy referred for CABG in two centers where TOAC strategy is employed. The main in-hospital outcomes of interest were death, stroke, acute myocardial infarction, new onset renal failure, resternotomy, and their composite. In the TOAC group of 103 patients CABG was performed during therapeutic oral anticoagulation and in the control group (81 patients) preoperative INR was lowered to a subtherape... Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5362714 Mon, 20 Jun 2011 04:00:00 +0100 5362714 http://www.medworm.com/index.php?rid=5362713&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811002805%2Fabstract%3Frss%3Dyes Abstract: Introduction: Although very late stent thrombosis is an important problem with drug-eluting stents, risks for in-stent thrombus formation have not been clarified. Therefore, we examined the risks among patient and lesion characteristics by direct visualization of the stented lesion by angioscopy.Materials and methods: Consecutive patients (n=118) who received successful angioscopic examination of drug-eluting (sirolimus- or paclitaxel-eluting) stents at 1-year after implantation were included. Presence or absence of thrombus directly on the area of each condition determined by the combination of lesion color (white or yellow) and neointima coverage (grade 0−2) was evaluated for each stent; and the factors associated with the presence of thrombus were analyzed.Results: Multivari... Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5362713 Wed, 15 Jun 2011 04:00:00 +0100 5362713 http://www.medworm.com/index.php?rid=5251599&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811002799%2Fabstract%3Frss%3Dyes Conclusion: regardless genotypes associated with moderate hyperhomocysteinemia, following a methionine loading test, in vivo oxidative stress and platelet activation occur, being the latter maximal in subjects with a history of early-onset thrombosis. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5251599 Mon, 13 Jun 2011 04:00:00 +0100 5251599 http://www.medworm.com/index.php?rid=5040861&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811002714%2Fabstract%3Frss%3Dyes Oral anticoagulation is one of the most widely employed medical treatments with approximately 1 million patients in the UK alone receiving warfarin or alternative oral anticoagulant drug. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5040861 Thu, 09 Jun 2011 23:00:00 +0100 5040861 http://www.medworm.com/index.php?rid=5362711&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811002271%2Fabstract%3Frss%3Dyes Abstract: Introduction: There is an exponential rise of thromboembolic risk with age because of co-morbidities, immobility and pharmacotherapy. We aimed to investigate the benefits and risks of heparin prophylaxis in very elderly patients ≥80years and the type of heparin used in a subgroup analysis of the CERTIFY trial.Patients/methods: 3,239 patients were randomized to 3,000 U aXa o.d. certoparin or 5,000IUt.i.d. unfractionated heparin (UFH) for 8–20days.Results: Patients ≥80years (n=1,365) were more likely to be female, had a lower mean bodyweight, were more frequently using antiplatelets and had a GFR below 30ml/min/1.73m2 more often than patients (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5362711 Thu, 09 Jun 2011 04:00:00 +0100 5362711 http://www.medworm.com/index.php?rid=4904924&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811002738%2Fabstract%3Frss%3Dyes (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=4904924 Tue, 07 Jun 2011 17:35:33 +0100 4904924 http://www.medworm.com/index.php?rid=5545219&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811002660%2Fabstract%3Frss%3Dyes Conclusions: These findings suggest that haemostasis and inflammation have at least partially separate roles in risk of myocardial infarction. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5545219 Mon, 06 Jun 2011 04:00:00 +0100 5545219 http://www.medworm.com/index.php?rid=5362712&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811002398%2Fabstract%3Frss%3Dyes Conclusions: Further well-designed trials are needed to evaluate the risks and benefits of statins in preventing VTE in heterogenous populations of adults, identify high-risk subgroups, and analyze cost-effectiveness of statin use for this indication. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5362712 Mon, 06 Jun 2011 04:00:00 +0100 5362712 http://www.medworm.com/index.php?rid=5251597&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811002386%2Fabstract%3Frss%3Dyes Conclusion: Our data regarding the D-dimer level may be helpful when considering the normal range of D-dimer for postpartum women with cesarean delivery. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5251597 Mon, 06 Jun 2011 04:00:00 +0100 5251597 http://www.medworm.com/index.php?rid=5251587&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811002404%2Fabstract%3Frss%3Dyes Conclusions: rFVIIa modulates thrombin generation primarily by accelerating the process, without significantly affecting the total amount of generated thrombin. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5251587 Mon, 06 Jun 2011 04:00:00 +0100 5251587 http://www.medworm.com/index.php?rid=5040868&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811002489%2Fabstract%3Frss%3Dyes Abstract: Background: Systemic thrombolysis rapidly improves right ventricular (RV) dysfunction in patients with acute pulmonary embolism (PE) but is associated with major bleeding complications in up to 20%. The efficacy of low-dose, catheter-directed ultrasound-accelerated thrombolysis (USAT) on the reversal of RV dysfunction is unknown.Materials and methods: We performed a retrospective analysis of 24 PE patients (60±16years) at intermediate (n=19) or high risk (n=5) from the East Jefferson General Hospital who were treated with USAT (mean rt-PA dose 33.5±15.5mg over 19.7hours) and received multiplanar contrast-enhanced chest computed tomography (CT) scans at baseline and after USAT at 38 ± 14hours. All CT measurements were performed by an independent core laboratory.Results: The rig... Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5040868 Sun, 05 Jun 2011 23:00:00 +0100 5040868 http://www.medworm.com/index.php?rid=5040863&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811001526%2Fabstract%3Frss%3Dyes Abstract: Nuclear factor kappa B (NFκB) is a transcription factor belonging to ‘Rel’ family that represents a crucial intracellular signal transduction system involved in several inflammatory diseases including atherosclerosis. Activation of NFκB mediated signal transduction has been established at different stages of atherosclerosis, beginning from plaque formation to its destabilization and rupture. The NFκB pathway is also involved in angiogenic, apoptotic and neoplastic processes. Experimental studies indicate that inhibition of these pathway may reduce inflammatory burden. The development of natural or pharmaceutical, selective and specific inhibitors of NFκB pathway over IκB kinase α or β, may ultimately prove to be promising anti-atherosclerotic, anti-inflammatory, antian... Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5040863 Thu, 02 Jun 2011 23:00:00 +0100 5040863 http://www.medworm.com/index.php?rid=5145059&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811002350%2Fabstract%3Frss%3Dyes Diabetic retinopathy (DR), defined by the presence of retinal microvascular lesions, is a leading cause of blindness in developed countries, affecting nearly all patients with type 1 diabetes and more than 60% of those with type 2 disease . (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5145059 Wed, 01 Jun 2011 23:00:00 +0100 5145059 http://www.medworm.com/index.php?rid=5251595&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811002295%2Fabstract%3Frss%3Dyes Abstract: Background: Chronic obstructive pulmonary disease (COPD) is associated with an increased risk for thromboembolic events. We investigated thrombin generation profiles in COPD patients and their dependence on plasma factor/inhibitor composition.Methods: Factors (f) (fII, fV, fVII, fVIII, fIX, fX), antithrombin, protein C (PC) and free tissue factor pathway inhibitor (fTFPI) from 60 COPD patients (aged 64.2±10.1years; a mean forced expiratory volume in 1 second [FEV1], 55.6±15.8% of predicted values) were compared with those for 43 controls matched for age, sex, weight and smoking. Patients receiving anticoagulation were excluded. Using each individual's plasma coagulation protein composition, tissue factor-initiated thrombin generation was assessed computationally.Results: COPD p... Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5251595 Tue, 31 May 2011 04:00:00 +0100 5251595 http://www.medworm.com/index.php?rid=5545218&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811001769%2Fabstract%3Frss%3Dyes Abstract: Introduction: MC710 is a mixture agent consisting of plasma-derived activated factor VII (FVIIa) and factor X (FX) at a weight ratio of 1:10 developed as a novel bypassing agent for the management of the bleeding of hemophilia patients with inhibitors. The pharmacokinetics, distribution, and excretion of 125I-labeled-FVIIa (125I-FVIIa) and -FX (125I-FX) were studied in male rats after a single intravenous administration of 125I-FVIIa or 125I-FX combined with MC710.Methods: 125I-FVIIa or 125I-FX was administered intravenously with MC710 to male rats in a single dosage (FVIIa 0.4mg and FX 4mg/kg body weight) and radioactivity and antigen levels in plasma were quantified for 24h. Urine and feces were sampled to study the excretion of radioactivity during 168h after dosing. Whole-bod... Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5545218 Mon, 30 May 2011 04:00:00 +0100 5545218 http://www.medworm.com/index.php?rid=5458931&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811002015%2Fabstract%3Frss%3Dyes Abstract: Introduction: Antiphospholipid Syndrome (APS) is characterized by the presence of circulating antiphospholipid antibodies in patients with thrombosis or pregnancy morbidity. Antibodies involved in these disorders are mainly those directed against β2-Glycoprotein I (β2GPI) with the major epitope apparently located on discontinuous antigen with several parts of Domain I (DmI) involved. The relation between anti-DmI antibodies and patients’ risk categories is unknown.Materials and Methods: The synthetic full-length and correctly-folded DmI (1–64) to set up a competitive inhibition enzyme-linked immunoadsorbent assays (ELISA) was used. Plasma of 22 patients with APS and triple positivity [Lupus Anticoagulant positive (LAC+), IgG anti-cardiolipin positive (aCL+), IgG anti-β2GPI... Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5458931 Mon, 30 May 2011 04:00:00 +0100 5458931 http://www.medworm.com/index.php?rid=5458930&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811001800%2Fabstract%3Frss%3Dyes Conclusions: Acute reversal of anticoagulant therapy with PTX-VF is associated with a significant rate of thromboembolism (4.6%) within 30days. These events can be explained by ongoing cessation of anticoagulant therapy in patients with ongoing risk factors for arterial or venous thrombosis, rather than directly attributable to PTX-VF therapy. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5458930 Mon, 30 May 2011 04:00:00 +0100 5458930 http://www.medworm.com/index.php?rid=5362716&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811002374%2Fabstract%3Frss%3Dyes In this study the in vitro effect of this drug was investigated on the interaction of platelets with leukocytes and on markers of leukocyte and platelet activation, including platelet microparticle formation. The analyses were performed by flow cytometry on citrated whole blood collected from healthy subjects and challenged by a mixture of collagen-ADP. Preliminarily, the epoprostenol antiplatelet effect was confirmed by both aggregometry and PFA-100 and by evaluation of intraplatelet VASP phosphorylation.Epoprostenol, at nanomolar concentrations, prevented the formation of platelet mixed conjugates with PMN or monocytes, platelet PAC-1 and P-selectin expression and platelet microparticle generation. The reference drugs PGE1, aspirin and the novel ADP-receptor antagonist, cangrelor, were o... Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5362716 Mon, 30 May 2011 04:00:00 +0100 5362716 http://www.medworm.com/index.php?rid=5251583&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811002337%2Fabstract%3Frss%3Dyes Conclusion: Ninety-five percent of the individuals had a MPV between 7.2 and 11.7fL. A patient having a MPV beyond this range should be evaluated carefully especially for occlusive arterial diseases. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5251583 Mon, 30 May 2011 04:00:00 +0100 5251583 http://www.medworm.com/index.php?rid=5251582&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811002349%2Fabstract%3Frss%3Dyes Conclusion: The influencing factors for platelet reactivity during clopidogrel therapy are assay-dependent. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5251582 Mon, 30 May 2011 04:00:00 +0100 5251582 http://www.medworm.com/index.php?rid=5251581&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811002313%2Fabstract%3Frss%3Dyes Abstract: Introduction: Venous thrombus resolution may be regulated by an angiogenic process that involves the surrounding vein wall. The aims of this study were to determine whether: (i) thrombosis stimulates activation of the angiogenic transcription factor, hypoxia-inducible factor (HIF) 1α, and downstream expression of growth factors in vein wall; and (ii) upregulation of HIF1α in vein wall leads to increased growth factor expression and enhanced thrombus resolution.Materials and methods: HIF1α, vascular endothelial growth factor (VEGF), and placental growth factor (PLGF) were quantified in mouse inferior vena cava (IVC) at days 1, 3, 7, and 14 after thrombus formation (n=10-13 per group). An additional group of thrombosed mice were treated with the prolyl-hydroxylase domain (PHD) i... Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5251581 Mon, 30 May 2011 04:00:00 +0100 5251581 http://www.medworm.com/index.php?rid=5251580&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811002258%2Fabstract%3Frss%3Dyes Abstract: Introduction: Numerous associations between chronic kidney disease (CKD) and atrial fibrillation (AF) have been reported and patients with CKD on anticoagulation therapy have an increased risk of bleeding. Currently, new anticoagulant agents are emerging in clinical practice, some of which are excreted by the kidneys. The proportion of AF patients on anticoagulant treatment with reduced renal function is, however, unknown.Materials and Methods: Using AURICULA, a Swedish registry for anticoagulation, estimated glomerular filtration rate (eGFR) was investigated in AF patients on warfarin treatment (n=2,603). The study group was compared with a healthy sample from the population (n=2,261). Two different creatinine prediction equations were used for calculating eGFR: the Lund-Malmö ... Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5251580 Mon, 30 May 2011 04:00:00 +0100 5251580 http://www.medworm.com/index.php?rid=5251579&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811002325%2Fabstract%3Frss%3Dyes Conclusions: In this pilot study we were able to successfully measure platelet surface charge variation as a measure of omega-3 PUFA effect on platelets. Our results suggest that omega-3 PUFA increase the total platelet surface charge and, therefore, attenuate platelet activation, even among patients taking aspirin or aspirin plus clopidogrel. Further studies are needed to determine the clinical significance of these measured effects and EQELS results. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5251579 Mon, 30 May 2011 04:00:00 +0100 5251579 http://www.medworm.com/index.php?rid=5145061&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS004938481100226X%2Fabstract%3Frss%3Dyes Protein C (PC) is a vitamin K-dependent serine protease zymogen, a member of a paralog gene family (comprising factor VII, IX, X and protein Z) involved in the coagulation cascade. In the presence of its cofactor protein S (PS), activated PC (APC) plays an important role in maintaining the haemostatic balance through inactivation of activated factor V (FVa) and activated factor VIII (FVIIIa) (for review see ). (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5145061 Sun, 29 May 2011 23:00:00 +0100 5145061 http://www.medworm.com/index.php?rid=5145058&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811002362%2Fabstract%3Frss%3Dyes Abstract: Neutrophil elastase released from activated neutrophils contributes in combating bacterial infection. While chronic inflammation results in anemia and decreased bone marrow activities, little is known about the effect of neutrophil elastase on hematological cell growth in severe inflammatory states. Here, we demonstrated that α1-antitrypsin, a physiological inhibitor of neutrophil elastase, functions as a regulator for cell growth by neutralizing neutrophil elastase activity in lipopolysaccharide-primed hematological cells. HL-60 cells were resistant to neutrophil elastase, as they also expressed α1-antitrypsin. The growth of HL-60 cells transduced with a LentiLox-short hairpin α1-antitrypsin vector was significantly suppressed by neutrophil elastase or lipopolysaccharide. Whe... Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5145058 Sun, 29 May 2011 23:00:00 +0100 5145058 http://www.medworm.com/index.php?rid=5145053&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811002283%2Fabstract%3Frss%3Dyes Conclusion: Specificity of an IgG-specific EIA for detecting platelet-activating antibodies can be optimized by applying the high heparin inhibition step to weak-positive reactions (0.5-≤1.0 OD). However, applying the high heparin inhibition step to strong-positive reactions (>1.0 OD) in our in-house assay risks falsely classifying a serum as negative for platelet-activating antibodies. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5145053 Sun, 29 May 2011 23:00:00 +0100 5145053 http://www.medworm.com/index.php?rid=5145046&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811001794%2Fabstract%3Frss%3Dyes Conclusion: VTE was associated with IL-6 and IL-8 levels, and for IL-6 this association was independent of BMI and hs-CRP. Thus far, a causal relationship between inflammation and VTE remains to be clarified and more prospective data are warranted. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5145046 Sun, 29 May 2011 23:00:00 +0100 5145046 http://www.medworm.com/index.php?rid=5040878&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811001770%2Fabstract%3Frss%3Dyes Acquired inhibitor to coagulation factor VIII is a rare but potentially life-threatening state. Drug-induced factor VIII inhibitors have attracted our attention. In particular, there is increased evidence for an association with interferon-alpha therapy. There have been eight documented cases . Herein we report a second case of chronic myelogenous leukemia (CML) presenting with acquired FVIII inhibitor during interferon-alpha therapy. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5040878 Sun, 29 May 2011 23:00:00 +0100 5040878 http://www.medworm.com/index.php?rid=5251578&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811002003%2Fabstract%3Frss%3Dyes Conclusions: Although less than 50% of INR results were within the TTR, oral anticoagulant management resulted in acceptable safety and efficacy outcomes for this cohort. Further studies are needed to confirm optimal paediatric-specific warfarin management strategies for children with prosthetic heart valves. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5251578 Fri, 27 May 2011 04:00:00 +0100 5251578 http://www.medworm.com/index.php?rid=4865150&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811002428%2Fabstract%3Frss%3Dyes (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=4865150 Thu, 26 May 2011 17:29:45 +0100 4865150 http://www.medworm.com/index.php?rid=5251596&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811002301%2Fabstract%3Frss%3Dyes Conclusions: The low molecular weight heparins studied have obvious antiangiogenic effects. There may be a difference in the potency of the drugs that could have a significant implication for further clinical research. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5251596 Wed, 25 May 2011 04:00:00 +0100 5251596 http://www.medworm.com/index.php?rid=5251594&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811001824%2Fabstract%3Frss%3Dyes Conclusions: Our results demonstrated that chronic cocaine consumption alters several functions of the endothelium towards a pro-thrombotic condition and that some of those functions remain abnormal even after short-term drug withdrawal. These observations support the notion that endothelial dysfunction may play a key role in the pathogenesis of ischemic vascular disease observed in cocaine abusers. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5251594 Wed, 25 May 2011 04:00:00 +0100 5251594 http://www.medworm.com/index.php?rid=5251577&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811001757%2Fabstract%3Frss%3Dyes Abstract: The demand for oral anticoagulant therapy (OAT) has constantly increased during the last ten years with an extended use of computer assistance. Many mathematical algorithms have been projected to suggest doses and time to next visit for patients on OAT. We designed a new algorithm: “Zeus”.A “before-after” study was planned to compare the efficacy and safety of this algorithm dosing OAT with manual dosage decided by the same expert physicians according to the target of International Normalized Ratio (INR). The study analysed data of 1876 patients managed with each of the two modalities for eight months, with an interval of two years between them.The aim was to verify the increased quality of therapy by time spent in INR target and efficiency and safety of Zeus algorithm. T... Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5251577 Fri, 20 May 2011 04:00:00 +0100 5251577 http://www.medworm.com/index.php?rid=5145051&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811001812%2Fabstract%3Frss%3Dyes Conclusions: This study demonstrates that the role of platelet P-selectin is not solely adhesive; its binding to PSGL-1 induces platelet activation that enhances platelet aggregation and thrombus formation. Therefore, targeting platelet P-selectin or its ligand PSGL-1 could provide a potential therapeutic approach in the management of thrombotic disorders. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5145051 Thu, 19 May 2011 23:00:00 +0100 5145051 http://www.medworm.com/index.php?rid=5145048&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811001782%2Fabstract%3Frss%3Dyes Conclusions: Asking a patient about past exposure of venous thrombosis risk factors long before the occurrence of a first venous thrombosis occurred, does not provide information to classify patients at lower risk for recurrence of venous thrombosis. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5145048 Thu, 19 May 2011 23:00:00 +0100 5145048 http://www.medworm.com/index.php?rid=5251575&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811001733%2Fabstract%3Frss%3Dyes Abstract: Clopidogrel has become the mainstay oral antiplatelet regimen to prevent recurrent ischemic events after acute coronary syndromes or stent placement. However, there is marked interindividual variability in the antiplatelet effects of clopidogrel, and a reduced response to this drug may be a risk factor for ischemic complications. Pharmacogenomic analyses, including candidate-gene and genome-wide association studies, have confirmed that genetic polymorphisms in the hepatic cytochrome P450 (CYP) 2C19 dominantly affect the antiplatelet effects of clopidogrel. CYP2C19 reduced-function alleles have been associated with a significant decrease in clopidogrel responsiveness and a higher risk of adverse cardiac events including stent thrombosis, myocardial infarction, and death in several... Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5251575 Thu, 19 May 2011 04:00:00 +0100 5251575 http://www.medworm.com/index.php?rid=5145045&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811001745%2Fabstract%3Frss%3Dyes Abstract: Vitamin K antagtonists (VKAs) have, for decades, been the corner-stone of anticoagulation in the outpatient setting. While the long half life makes once daily administration practical, close monitoring of VKA effect is necessary because these medicines have a narrow therapeutic index. Despite inter-individual variations in response to VKA doses, the increasing availability of specialized anticoagulation monitoring systems, along with a better understanding of potential drug and dietary interactions, has made the use of VKAs safer and less burdensome. In the future, newer classes of oral anticoagulants and genomic-based dosing strategies may further expand or improve the management options for many patients at risk for thromboembolism. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5145045 Thu, 12 May 2011 23:00:00 +0100 5145045 http://www.medworm.com/index.php?rid=5458929&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811001721%2Fabstract%3Frss%3Dyes Conclusions: These findings suggest that like rFVIIa, NN1731 improves the formation, structure, and stability of hemophilic clots. Higher lipid concentrations may facilitate assessment of both rFVIIa and NN1731 activity. NN1731 appears likely to support rapid clot formation in tissues with high endogenous fibrinolytic activity. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5458929 Wed, 11 May 2011 04:00:00 +0100 5458929 http://www.medworm.com/index.php?rid=5251593&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811001599%2Fabstract%3Frss%3Dyes Conclusions: It may not be suitable to use the same reference ranges for pregnant women as for the general population. Therefore, we suggest new reference limits for thromboelastography in pregnant women. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5251593 Thu, 05 May 2011 04:00:00 +0100 5251593 http://www.medworm.com/index.php?rid=5145052&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS004938481100154X%2Fabstract%3Frss%3Dyes Conclusions: Our results suggest that the effect of Klotho C1818T variant on levels of plasma NOx becomes pronounced with age probably implying the adaptive capability of Klotho alleles to meet the age-related increasing physiological load. (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5145052 Wed, 04 May 2011 23:00:00 +0100 5145052 http://www.medworm.com/index.php?rid=5040877&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811001605%2Fabstract%3Frss%3Dyes Oral contraceptive (OC) use affects the plasma levels of several pro- and anticoagulant as well as fibrinolytic factors, overall leading to an increased risk of venous thrombosis. The estrogen in OCs is considered to be the main prothrombotic constituent, however, the introduction of the third generation contraceptives containing desogestrel instead of levonorgestrel, revealed a modulating anti-estrogenic effect of progestins on estrogen-induced alterations in thrombotic risk and the coagulation profile . Such anti-estrogenic effects of progestins are established for murine uterine gene transcription . Here, we examined the anti-estrogenic effects of the second-generation progestin levonorgestrel (LNG) and third-generation desogestrel (DSG) on coagulation factor gene transcription in the l... Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5040877 Tue, 03 May 2011 23:00:00 +0100 5040877 http://www.medworm.com/index.php?rid=5040876&cid=s_36108_19_f&fid=36108&url=http%3A%2F%2Fwww.thrombosisresearch.com%2Farticle%2FPIIS0049384811001551%2Fabstract%3Frss%3Dyes Mortensen et al. have recently published a study describing the impact of the presence of type 2 diabetes mellitus on the anti-platelet effect of aspirin in patients with coronary artery disease (CAD) . Here we describe data relating to the effect of aspirin in patients presenting with high risk acute coronary syndromes (ACS) (Source: Thrombosis Research) Thrombosis Research journals http://www.medworm.com/rss/comments.php?id=5040876 Tue, 03 May 2011 23:00:00 +0100 5040876