MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Thrombosis and Haemostasis' source. Wed, 08 Feb 2012 17:42:12 +0100 http://www.medworm.com/index.php?rid=5644491&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22273694%26dopt%3DAbstract Authors: Mallouk N, Labruyere C, Reny JL, Chapelle C, Piot M, Fontana P, Gris JC, Delavenne X, Mismetti P, Laporte S Abstract The existence of poor biological response to clopidogrel has been shown in some patients. Despite the increasing number of studies, this phenomenon remains difficult to quantify. We performed a systematic review to estimate the prevalence of poor biological response to clopidogrel and investigate the factors known to modulate this. An exhaustive search was performed. Altogether 171 publications were identified, providing data for a total of 45,664 subjects. The estimated prevalence of poor biological response to clopidogrel ranged from 15.9% to 49.5% according to the platelet function assay employed. The assays most frequently used were light transmittance a... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5644491 Wed, 25 Jan 2012 05:00:00 +0100 5644491 http://www.medworm.com/index.php?rid=5644490&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22273731%26dopt%3DAbstract Authors: Tormene D, Grandone E, De Stefano V, Tosetto A, Palareti G, Margaglione M, Castaman G, Rossi E, Ciminello A, Valdrè L, Legnani C, Tiscia GL, Bafunno V, Carraro S, Rodeghiero F, Simioni P Abstract Whether the administration of low-molecular-weight heparin (LMWH) during pregnancy is effective in preventing obstetric complications and pregnancy-related venous thromboembolism (VTE) in women who are carriers of factor V Leiden (FVL) and/or prothrombin variant G20210A (PTm) is controversial. This observational study investigated the possible efficacy of pharmacological treatment with LMWH ± aspirin (ASA) in pregnancy outcomes in 1,011 pregnancies of 416 women with thrombophilia (FVL and/or PTm). Most patients were chosen on the basis of previous obstetrical complications (36%)... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5644490 Wed, 25 Jan 2012 05:00:00 +0100 5644490 http://www.medworm.com/index.php?rid=5644489&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22273764%26dopt%3DAbstract Authors: Gröpper S, Althaus K, Najm J, Haase S, Aul C, Greinacher A, Giagounidis A PMID: 22273764 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5644489 Wed, 25 Jan 2012 05:00:00 +0100 5644489 http://www.medworm.com/index.php?rid=5644488&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22273812%26dopt%3DAbstract Authors: Jeff JM, Brown-Gentry K, Crawford DC Abstract Previous genetic association studies of the fibrinogen gene cluster have identified associations with plasma fibrinogen levels. These studies are typically limited to plasma fibrinogen measured among European-descent populations. We sought to replicate previous well-known associations with fibrinogen variants and plasma fibrinogen. We then sought to identify and characterise novel associations with fibrinogen variants with plasma fibrinogen and several haematological traits in three racial/ethnic populations. We genotyped 25 single nucleotide polymorphisms (SNPs) in the fibrinogen gene cluster in 2,631 non-Hispanic whites, 2,108 non-Hispanic blacks, and 2,073 Mexican-Americans from the Third National Health and Nutrition Examin... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5644488 Wed, 25 Jan 2012 05:00:00 +0100 5644488 http://www.medworm.com/index.php?rid=5644487&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22273845%26dopt%3DAbstract In conclusion, during anticoagulant therapy VT patients have APC levels disproportionately higher than the corresponding PC levels, mainly due to the presence of the PROCR H1 haplotype. Furthermore, a sufficiently carboxylated PC Gla-domain seems to be essential for PC activation in vivo . PMID: 22273845 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5644487 Wed, 25 Jan 2012 05:00:00 +0100 5644487 http://www.medworm.com/index.php?rid=5644486&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22273984%26dopt%3DAbstract Authors: Mulder R, Ten Kate MK, Kluin-Nelemans HC, Mulder AB PMID: 22273984 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5644486 Wed, 25 Jan 2012 05:00:00 +0100 5644486 http://www.medworm.com/index.php?rid=5644485&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22274138%26dopt%3DAbstract Authors: Souri M, Sugiura-Ogasawara M, Saito S, Kemkes-Matthes B, Meijers JC, Ichinose A Abstract Protein Z (PZ)-dependent protease inhibitor (ZPI) is a serine protease inhibitor which efficiently inactivates activated factor X, when ZPI is complexed with PZ in plasma. Reduced plasma levels of ZPI and PZ have been reported in association with thrombosis. It has also been reported that PZ increases during pregnancy and that its partial deficiency is related to early pregnancy loss or recurrent miscarriage (RM). However, until now there has been no report on ZPI in pregnancy. To explore the possible role(s) of ZPI in the maintenance of pregnancy, we studied 42 non-pregnant normal women, 32 women with normal pregnancies, and 134 cases of unexplained RM in Japan, as well as 64 non-preg... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5644485 Wed, 25 Jan 2012 05:00:00 +0100 5644485 http://www.medworm.com/index.php?rid=5644484&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22274299%26dopt%3DAbstract Authors: Van Laecke S, Nagler EV, Vanholder R Abstract Despite advances in more recent years, the pathophysiology and especially treatment modalities of thrombotic microangiopathy (TMA) largely remain enigmatic. Disruption of endothelial homeostasis plays an essential role in TMA. Considering the proven causal association between magnesium and both endothelial function and platelet aggregability, we speculate that a magnesium deficit could influence the course of TMA and the related haemolytic uraemic syndrome and thrombotic thrombocytopenic purpura. A predisposition towards TMA is seen in many conditions with both extracellular and intracellular magnesium deficiency. We propose a rationale for magnesium supplementation in TMA, in analogy with its evidence-based therapeutic applica... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5644484 Wed, 25 Jan 2012 05:00:00 +0100 5644484 http://www.medworm.com/index.php?rid=5644483&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22274403%26dopt%3DAbstract Authors: Freynhofer MK, Bruno V, Willheim M, Hübl W, Wojta J, Huber K Abstract The vasodilator-stimulated phosphoprotein-phosphorylation (VASP-P) flow-cytometric assay is mainly used in clinical trials to measure thienopyridine effects. However, there are remarkable differences in the reported optimal cut-offs, ranging from 48-61% platelet reactivity index (PRI). We therefore investigated whether a lack of standardisation might explain the differences in the cut-offs. We measured VASP-P in 62 individuals. PRI was calculated using the mean, geometric mean and median fluorescence intensities (FI). Stability of the blood-samples (time-to-assay, 0-2 days) and stability of the processed samples (0-120 minutes) within the recommended time-span were tested. Time-to-assay significantly in... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5644483 Wed, 25 Jan 2012 05:00:00 +0100 5644483 http://www.medworm.com/index.php?rid=5644482&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22274545%26dopt%3DAbstract Authors: Pankiw-Bembenek O, Zalewski J, Goralczyk T, Undas A Abstract It has been demonstrated that formation of compact plasma fibrin clots resistant to plasmin-mediated lysis characterises patients following in-stent thrombosis (IST). The relationship between defective fibrinolysis, reflected as prolonged clot lysis time (CLT) and IST is unclear. We sought to investigate whether patients with acute and subacute IST have impaired fibrinolytic capacity. We studied 41 definite IST patients, including 15 with acute and 26 with subacute IST experienced 2-73 months prior to enrollment, versus 41 controls matched for demographics, cardiovascular risk factors, concomitant treatment and angiographic/stent parameters. CLT, reflecting lysis of a tissue factor-induced plasma clot by exogenou... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5644482 Wed, 25 Jan 2012 05:00:00 +0100 5644482 http://www.medworm.com/index.php?rid=5644481&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22274593%26dopt%3DAbstract In conclusion, a fatty meal consumption may represent a model of acute inflammatory response and appears to be modulated by different demographic and cardiovascular risk degree. This model could be applied to study the effect of food-derived antioxidants or nutritional supplements, but its relevance remains to be demonstrated. PMID: 22274593 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5644481 Wed, 25 Jan 2012 05:00:00 +0100 5644481 http://www.medworm.com/index.php?rid=5644480&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22274626%26dopt%3DAbstract Authors: Rayner KJ, Fernandez-Hernando C, Moore KJ Abstract MicroRNAs have emerged as important post-transcriptional regulators of lipid metabolism, and represent a new class of targets for therapeutic intervention. Recently, microRNA-33a and b (miR-33a/b) were discovered as key regulators of metabolic programs including cholesterol and fatty acid homeostasis. These intronic microRNAs are embedded in the sterol response element binding protein genes, SREBF2 and SREBF1 , which code for transcription factors that coordinate cholesterol and fatty acid synthesis. By repressing a variety of genes involved in cholesterol export and fatty acid oxidation, including ABCA1 , CROT , CPT1 , HADHB and PRKAA1 , miR-33a/b act in concert with their host genes to boost cellular sterol levels. Recen... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5644480 Wed, 25 Jan 2012 05:00:00 +0100 5644480 http://www.medworm.com/index.php?rid=5644479&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22274652%26dopt%3DAbstract Authors: Lenglet S, Thomas A, Chaurand P, Galan K, Mach F, Montecucco F Abstract Ischaemic stroke and myocardial infarction often result from the sudden rupture of an atherosclerotic plaque. The subsequent arterial thrombosis occluding the vessel lumen has been widely indicated as the crucial acute event causing peripheral tissue ischaemia. A complex cross-talk between systemic and intraplaque inflammatory mediators has been shown to regulate maturation, remodeling and final rupture of an atherosclerotic plaque. Matrix metalloproteinases (MMPs) are proteolytic enzymes (released by several cell subsets within atherosclerotic plaques), which favour atherogenesis and increase plaque vulnerability. Thus, the assessment of intraplaque levels and activity of MMP might be of pivotal relev... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5644479 Wed, 25 Jan 2012 05:00:00 +0100 5644479 http://www.medworm.com/index.php?rid=5644478&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22274722%26dopt%3DAbstract Authors: Rühl H, Müller J, Harbrecht U, Fimmers R, Oldenburg J, Mayer G, Pötzsch B Abstract Inhibition of thrombin by endogenous inhibitors plays a central role in the spatiotemporal control of clot formation. A failure to adequately inactivate thrombin such as in antithrombin deficiency generates a strong prothrombotic phenotype. To study if and to what extent delayed thrombin inactivation rates beyond antithrombin deficiency contribute to the prothrombotic phenotype we measured thrombin inhibition profiles in plasma samples obtained from 16 healthy individuals and 39 thrombophilic patients, including 17 patients diagnosed positive for anti-prothrombin/phospholipid antibodies. To test thrombin inhibition, thrombin was added to plasma, and endogenous thrombin inhibition stopped ... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5644478 Wed, 25 Jan 2012 05:00:00 +0100 5644478 http://www.medworm.com/index.php?rid=5644477&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22274747%26dopt%3DAbstract Authors: Cotechini T, Othman M, Graham CH Abstract Inflammation-associated foetal loss is often linked to maternal coagulopathies. Here, we characterised the role of maternal inflammation in the development of various systemic maternal coagulopathies and foetal death during mid-to-late gestation in rats. Since nitric oxide (NO) functions as an inhibitor of platelet aggregation and anti-oxidant, we also tested whether the NO mimetic nitroglycerin (glyceryl trinitrate, GTN) prevents inflammation-associated coagulopathies and foetal death. To induce chronic inflammation, pregnant Wistar rats were injected with low-doses of lipopolysaccharide (LPS; 10-40 μg/kg) on gestational days (GD) 13.5-16.5. To determine whether the effects of inflammation are mediated by tumour necrosis factor-�... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5644477 Wed, 25 Jan 2012 05:00:00 +0100 5644477 http://www.medworm.com/index.php?rid=5644476&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22274761%26dopt%3DAbstract Authors: Al-Tamimi M, Arthur JF, Gardiner E, Andrews RK Abstract New methods for analysing both platelet and plasma forms of the platelet-specific collagen receptor, glycoprotein VI (GPVI) in experimental models or human clinical samples, and the development of the first therapeutic compounds based on dimeric soluble GPVI-Fc or anti-GPVI antibody-based constructs, coincide with increased understanding of the potential pathophysiological role of GPVI ligand binding and shedding. Platelet GPVI not only mediates platelet activation at the site of vascular injury where collagen is exposed, but is also implicated in the pathogenesis of other diseases, such as atherosclerosis and coagulopathy, rheumatoid arthritis and tumour metastasis. Here, we describe some of the critical mechanisms f... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5644476 Wed, 25 Jan 2012 05:00:00 +0100 5644476 http://www.medworm.com/index.php?rid=5644475&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22274796%26dopt%3DAbstract Authors: Perrin J, Barraud D, Toussaint-Hacquard M, Bollaert PE, Lecompte T PMID: 22274796 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5644475 Wed, 25 Jan 2012 05:00:00 +0100 5644475 http://www.medworm.com/index.php?rid=5580362&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22234312%26dopt%3DAbstract Authors: Ofosu FA Abstract With the expiry or pending expiry of originator low-molecular-weight heparin (LMWH) patents, pharmaceutical companies have invested in developing non-proprietary versions of LMWHs. LMWHs are manufactured by depolymerising highly purified unfractionated heparin. In contrast to traditional synthetic drugs with well-defined chemical structures, LMWHs contain complex oligosaccharide mixtures and the different manufacturing processes for LMWHs add to the heterogeneity in their physicochemical properties such that the European Medicines Agency (EMA) and the USA Food and Drug Administration (FDA) consider existing originator LMWHs to be distinct medicinal entities that are not clinically interchangeable. The FDA views LMWHs as drugs and has approved two non-prop... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5580362 Wed, 11 Jan 2012 05:00:00 +0100 5580362 http://www.medworm.com/index.php?rid=5580361&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22234313%26dopt%3DAbstract Authors: Toth P, Makris M PMID: 22234313 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5580361 Wed, 11 Jan 2012 05:00:00 +0100 5580361 http://www.medworm.com/index.php?rid=5580360&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22234341%26dopt%3DAbstract Authors: Hamesch K, Subramanian P, Li X, Dembowsky K, Chevalier E, Weber C, Schober A Abstract Impaired endothelial recovery after the implantation of drug-eluting stents is a major concern because of the increased risk for late stent thrombosis. The disruption of the chemokine axis CXCL12/CXCR4 inhibits neointima formation by blocking the recruitment of smooth muscle progenitor cells. To directly compare a CXCR4-targeting treatment strategy with drugs that are currently used for stent coating, we studied the effects of the CXCR4 antagonist POL5551 and the drug sirolimus on neointima formation. Apolipoprotein E-deficient mice were treated with POL5551 or sirolimus continuously for 28 days after a carotid wire injury. POL5551 inhibited neointima formation by 63% (for a dosage of 2 m... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5580360 Wed, 11 Jan 2012 05:00:00 +0100 5580360 http://www.medworm.com/index.php?rid=5580359&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22234363%26dopt%3DAbstract We examined the applicability of thrombin inhibitor containing blood for platelet reactivity index (PRI) measurements of the VASP assay and investigated the effects of two thrombin inhibitors (hirudin and lepirudin) on cAMP- and cGMP-mediated signalling pathways in washed human platelets. We show that induction of VASP phosphorylation by PGE1 is markedly reduced in lepirudin containing blood samples. In consequence, PRI levels were highly variable compared to routinely used citrated blood. Surprisingly, in vitro incubation of platelets with thrombin inhibitors increases platelet cGMP levels and induces NOS independent sGC/PKG-mediated VASP phosphorylation. We conclude that thrombin inhibitors activate sGC/PKG-dependent pathways resulting in an increase of VASP phosphorylation which contrib... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5580359 Wed, 11 Jan 2012 05:00:00 +0100 5580359 http://www.medworm.com/index.php?rid=5580358&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22234385%26dopt%3DAbstract Authors: Kristensen SD, Würtz M, Grove EL, De Caterina R, Huber K, Moliterno DJ, Neumann FJ Abstract Platelet glycoprotein IIb/IIIa inhibitors (GPI) are antithrombotic agents preventing the binding of fibrinogen to GP IIb/IIIa receptors. Thus, GPI interfere with interplatelet bridging mediated by fibrinogen. Currently, three generic GPI with different antithrombotic properties are available for intravenous administration: abciximab, eptifibatide, and tirofiban. The development of oral GPI was abandoned, whereas intravenous GPI were introduced in various clinical settings during the 1990s, yielding substantial benefit in the treatment of acute coronary syndromes, particularly during percutaneous coronary interventions. Results of the many randomised trials evidenced the efficacy of... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5580358 Wed, 11 Jan 2012 05:00:00 +0100 5580358 http://www.medworm.com/index.php?rid=5580357&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22234396%26dopt%3DAbstract This study provided a detailed map of the FVIII A2 domain between residues 371 and 649, identifying residues crucial for maintaining FVIII function and residues that can be mutated without jeopardising the coagulant activity. PMID: 22234396 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5580357 Wed, 11 Jan 2012 05:00:00 +0100 5580357 http://www.medworm.com/index.php?rid=5580356&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22234425%26dopt%3DAbstract In conclusion, our study shows that when used in conjunction with a low PTP some DD assays are useful tools for the exclusion of distal leg DVT. PMID: 22234425 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5580356 Wed, 11 Jan 2012 05:00:00 +0100 5580356 http://www.medworm.com/index.php?rid=5580355&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22234447%26dopt%3DAbstract Authors: Breen KA, Seed P, Parmar K, Moore GW, Stuart-Smith SE, Hunt BJ Abstract The antiphospholipid syndrome (APS) is the association of thrombosis and recurrent pregnancy loss and/or pregnancy morbidity with persistent antiphospholipid antibodies (aPL). Increased complement activation has been implicated in the pathogenesis of APS in animal models. It was our objective to evaluate complement activation in patients with aPL or primary antiphospholipid syndrome (PAPS). We measured complement activation products, fragments Bb and C3a-desArg by ELISA in 186 aPL/PAPS patients and 30 healthy controls. All patients with aPL had significantly increased levels of complement activation products. Fragment Bb levels (mean, 95% CI); (thrombotic APS 0.54 units/ml, 0.31-0.83, obstetric APS 0.6... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5580355 Wed, 11 Jan 2012 05:00:00 +0100 5580355 http://www.medworm.com/index.php?rid=5580354&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22234485%26dopt%3DAbstract In conclusion, treatment with SphK inhibitor leads to both pro- and anti-atherogenic effects in LDL-R-/- mice. As a consequence, SphK inhibition fails to affect atherosclerosis despite significant S1P reduction in plasma. PMID: 22234485 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5580354 Wed, 11 Jan 2012 05:00:00 +0100 5580354 http://www.medworm.com/index.php?rid=5580353&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22234520%26dopt%3DAbstract Authors: Fujii N, Souri M, Ichinose A PMID: 22234520 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5580353 Wed, 11 Jan 2012 05:00:00 +0100 5580353 http://www.medworm.com/index.php?rid=5580352&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22234563%26dopt%3DAbstract Authors: Falcón BJ, Cotechini T, Macdonald-Goodfellow SK, Othman M, Graham CH Abstract Spontaneous pregnancy loss is often associated with aberrant maternal inflammation and systemic coagulopathies. However, the role of inflammation in the development of obstetric coagulopathies is poorly understood. Further, questions remain as to whether systemic coagulopathies are linked to placental haemostatic alterations, and whether these local alterations contribute to a negative foetal outcome. Using a model of spontaneous foetal loss in which pregnant rats are given a single injection of bacterial lipopolysaccharide (LPS), we characterised the systemic maternal coagulation status following LPS administration using thromboelastography (TEG), a global haemostatic assay that measures the ki... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5580352 Wed, 11 Jan 2012 05:00:00 +0100 5580352 http://www.medworm.com/index.php?rid=5580351&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22234599%26dopt%3DAbstract Authors: Morel-Kopp MC, Tan CW, Brighton TA, McRae S, Baker R, Tran H, Mollee P, Kershaw G, Joseph J, Ward C, Abstract Heparin-induced thrombocytopenia (HIT) remains a challenge, with diagnosis confirmed only by functional assays. The gold standard 14C-serotonin release assay (SRA) is highly sensitive but technically challenging and unsuitable for routine use. We conducted a large study to validate whole blood impedance aggregometry (WBIA) as a suitable diagnostic tool for HIT. WBIA and SRA were used to test 181 samples positive for H-PF4 antibodies by PaGIA or ELISA. Using the same high responder donor, 77 samples were positive by WBIA (aggregation with low-dose but not high-dose heparin). Using the strict definition for SRA positivity, 72 samples were true HIT. In nine samples, ... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5580351 Wed, 11 Jan 2012 05:00:00 +0100 5580351 http://www.medworm.com/index.php?rid=5580350&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22234635%26dopt%3DAbstract Authors: Glauser BF, Vairo BC, Oliveira SN, Cinelli LP, Pereira MS, Mourão PA Abstract Patent protection for enoxaparin has expired. Generic preparations are developed and approved for clinical use in different countries. However, there is still skepticism about the possibility of making an exact copy of the original drug due to the complex processes involved in generating low-molecular-weight heparins. We have undertaken a careful analysis of generic versions of enoxaparin available for clinical use in Brazil. Thirty-three batches of active ingredient and 70 of the final pharmaceutical product were obtained from six different suppliers. They were analysed for their chemical composition, molecular size distribution, in vitro anticoagulant activity and pharmacological effects on an... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5580350 Wed, 11 Jan 2012 05:00:00 +0100 5580350 http://www.medworm.com/index.php?rid=5580349&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22234657%26dopt%3DAbstract In conclusion, the incidence rate of VTE in patients with hyperthyroidism appears to be high. Future prospective studies are needed to further explore this possible association and to address its clinical implications. PMID: 22234657 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5580349 Wed, 11 Jan 2012 05:00:00 +0100 5580349 http://www.medworm.com/index.php?rid=5580348&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22234708%26dopt%3DAbstract Authors: Matsumoto T, Nogami K, Ogiwara K, Shima M Abstract Acquired haemophilia A (AHA) is caused by the development of factor (F)VIII autoantibodies, demonstrating type 1 or type 2 inhibitory behaviour, and results in more serious haemorrhagic symptoms than in congenital severe HA. The reason(s) for this remains unknown, however. The global coagulation assays, thrombin generation tests and clot waveform analysis, demonstrated that coagulation parameters in patients with AHA-type 2 inhibitor were more significantly depressed than those in patients with moderate HA with similar FVIII activities. Thrombin and intrinsic FXa generation tests were significantly depressed in AHA-type 1 and AHA-type 2 compared to severe HA, and more defective in AHA-type 1 than in AHA-type 2. To investig... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5580348 Wed, 11 Jan 2012 05:00:00 +0100 5580348 http://www.medworm.com/index.php?rid=5580347&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22234719%26dopt%3DAbstract Authors: de la Morena-Barrio ME, Antón AI, Martínez-Martínez I, Padilla J, Miñano A, Navarro-Fernández J, Aguila S, López MF, Fontcuberta J, Vicente V, Corral J Abstract Antithrombin is the main endogenous anticoagulant. Impaired function or deficiency of this molecule significantly increases the risk of thrombosis. We studied the genetic variability of SERPINC1, the gene encoding antithrombin, to identify mutations affecting regulatory regions with functional effect on its levels. We sequenced 15,375 bp of this gene, including the potential promoter region, in three groups of subjects: five healthy subjects with antithrombin levels in the lowest (75%) and highest (115%) ranges of our population, 14 patients with venous thrombosis and a moderate antithrombin deficiency as the... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5580347 Wed, 11 Jan 2012 05:00:00 +0100 5580347 http://www.medworm.com/index.php?rid=5580346&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22234746%26dopt%3DAbstract In conclusion, increased levels of M-plt could be a predictive marker for both early outcome and long-term prognosis while increased CD40L was correlated with worse clinical outcome. PMID: 22234746 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5580346 Wed, 11 Jan 2012 05:00:00 +0100 5580346 http://www.medworm.com/index.php?rid=5580345&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22234747%26dopt%3DAbstract Authors: Hayward CP, Moffat KA, Castilloux JF, Liu Y, Seecharan J, Tasneem S, Carlino S, Cormier A, Rivard GE Abstract Platelet aggregometry and dense granule adenosine triphosphate (ATP) release assays are helpful to diagnose platelet disorders. Some laboratories simultaneously measure aggregation and ATP release using Chronolume® a commercial reagent containing D-luciferin, firefly luciferase and magnesium. Chronolume® can potentiate sub-maximal aggregation responses, normalising canine platelet disorder findings. We investigated if Chronolume® potentiates human platelet aggregation responses after observing discrepancies suspicious of potentiation. Among patients simultaneously tested by light transmission aggregometry (LTA) on two instruments, 18/43 (42%), including 14/24 (5... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5580345 Wed, 11 Jan 2012 05:00:00 +0100 5580345 http://www.medworm.com/index.php?rid=5568994&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22215260%26dopt%3DAbstract Authors: Lip GY, Weber C PMID: 22215260 [PubMed - in process] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5568994 Tue, 03 Jan 2012 05:00:00 +0100 5568994 http://www.medworm.com/index.php?rid=5568993&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22215261%26dopt%3DAbstract Authors: Weber C, Lip GY PMID: 22215261 [PubMed - in process] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5568993 Tue, 03 Jan 2012 05:00:00 +0100 5568993 http://www.medworm.com/index.php?rid=5481119&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22130699%26dopt%3DAbstract Authors: Badimon L, Padro T, Vilahur G Abstract Platelet deposition, adhesion/aggregation, to the damaged vessel wall or atherosclerotic plaque components has shown to play a major role in hemostasis, thrombosis, and the development of atherosclerosis. Platelet-vessel wall interaction and thrombus formation is driven by blood flow rheology/hemodynamics (changes in local flow conditions), the nature of the flowing blood, and the characteristics of the triggering substrate (lesion type). An extracorporeal perfusion system (the Badimon chamber) was developed to investigate the dynamics of platelet deposition and thrombus formation on: (a) different surfaces (biological and synthetic); (b) under controlled blood flow conditions with varying degrees of stenosis mimicking various vascula... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5481119 Thu, 08 Dec 2011 00:06:44 +0100 5481119 http://www.medworm.com/index.php?rid=5481118&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22131082%26dopt%3DAbstract Erratum to: "Venous thromboembolism in patients with intracranial haemorrhage" by Lobo et al. (Thromb Haemost 2011; 106: 750-752). Thromb Haemost. 2011 Nov 30;106(6):1234 Authors: PMID: 22131082 [PubMed - in process] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5481118 Wed, 30 Nov 2011 05:00:00 +0100 5481118 http://www.medworm.com/index.php?rid=5481117&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22131083%26dopt%3DAbstract Authors: PMID: 22131083 [PubMed - in process] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5481117 Wed, 30 Nov 2011 05:00:00 +0100 5481117 http://www.medworm.com/index.php?rid=5481116&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22131084%26dopt%3DAbstract Authors: PMID: 22131084 [PubMed - in process] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5481116 Wed, 30 Nov 2011 05:00:00 +0100 5481116 http://www.medworm.com/index.php?rid=5463796&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22116092%26dopt%3DAbstract In conclusion, sCD40L release from platelets was mediated by MMP-9, and MMP-9 expression was in turn upregulated by sCD40L in the MEG-01 cell line. We conclude that platelets and megakaryocytes might participate in a positive feedback loop occurring between sCD40L and MMP-9 whichwould contribute to the proinflammatory state observed in BD. PMID: 22116092 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5463796 Thu, 24 Nov 2011 05:00:00 +0100 5463796 http://www.medworm.com/index.php?rid=5463795&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22116191%26dopt%3DAbstract In conclusion, warfarin pharmacogenetic dosing can be optimised in real time utilising observed PK/PD information in an adaptive fashion. PMID: 22116191 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5463795 Thu, 24 Nov 2011 05:00:00 +0100 5463795 http://www.medworm.com/index.php?rid=5463794&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22116210%26dopt%3DAbstract Authors: Gayol S, Kirchgesner T, Kopferschmitt J, Meyer N, Sauleau E, Wiesel ML, Cazenave JP, Gachet C, Lanza F PMID: 22116210 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5463794 Thu, 24 Nov 2011 05:00:00 +0100 5463794 http://www.medworm.com/index.php?rid=5463793&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22116307%26dopt%3DAbstract In this study, we sought to assess the feasibility of a novel microbubble conjugated with cyclic RGD (Mb-cyclic RGD) in UMI of arterial thrombi in vitro and in vivo . As expected, Mb-cyclic RGD had greater GP IIb/IIIa-targeted binding capability in all shear stress conditions. In addition, the shear stress at half-maximal detachment of Mb-cyclic RGD was 5.7-fold higher than that of microbubbles with non-specific peptide (Mb-CON) (p<0.05). Mb-cyclic RGD enhanced the echogenicity of the platelet-rich thrombus in vitro whereas Mb-CON did not produce enhancement. In the in vivo setting, optimal signal enhancement of the abdominal aortic thrombus was displayed with Mb-cyclic RGD in all cases. Mean video intensity of the abdominal aortic thrombi with Mb-cyclic RGD was 3.2-fold higher than tha... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5463793 Thu, 24 Nov 2011 05:00:00 +0100 5463793 http://www.medworm.com/index.php?rid=5463792&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22116349%26dopt%3DAbstract Authors: Fish RJ, Vorjohann S, Béna F, Fort A, Neerman-Arbez M Abstract The zebrafish is a model organism for studying vertebrate development and many human diseases. Orthologues of the majority of human coagulation factors are present in zebrafish, including fibrinogen. As a first step towards using zebrafish to model human fibrinogen disorders, we cloned the zebrafish fibrinogen cDNAs and made in situ hybridisations and quantitative reverse transcription-polymerase chain reactions (qRT-PCR) to detect zebrafish fibrinogen mRNAs. Prior to liver development or blood flow we detected zebrafish fibrinogen expression in the embryonic yolk syncytial layer and then in the early cells of the developing liver. While human fibrinogen is encoded by a three-gene, 50 kilobase (kb) cluster on ... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5463792 Thu, 24 Nov 2011 05:00:00 +0100 5463792 http://www.medworm.com/index.php?rid=5463791&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22116393%26dopt%3DAbstract In conclusion, RANKL increased the release of neutrophilic products potentially related to the "blood" vulnerability via defined intracellular pathways. Serum levels of RANKL might represent a potential biomarker of coronary calcification and related cardiovascular risk. PMID: 22116393 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5463791 Thu, 24 Nov 2011 05:00:00 +0100 5463791 http://www.medworm.com/index.php?rid=5463790&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22116452%26dopt%3DAbstract Authors: Hoke M, Pernicka E, Niessner A, Goliasch G, Amighi J, Koppensteiner R, Minar E, Mlekusch W, Rumpold H, Wagner O, Schillinger M Abstract Renal dysfunction is a risk factor for mortality in patients with atherosclerosis. Estimated glomerular filtration rate (eGFR), cystatin C (CysC) and beta-2-microglobulin (B2M) are measures of renal function. It remains unclear, which of these parameters is the strongest predictor of outcome in patients with atherosclerosis. All-cause and cardiovascular mortality were prospectively investigated in 1,065 consecutive patients with asymptomatic carotid atherosclerosis. During a median follow-up of 6.3 years 275 patients died (25.8%), including 182 (66.2%) from cardiovascular causes. Estimated GFR, CysC and B2M were all significantly and indep... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5463790 Thu, 24 Nov 2011 05:00:00 +0100 5463790 http://www.medworm.com/index.php?rid=5463789&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22116496%26dopt%3DAbstract Authors: Marchena PJ, Nieto JA, Guil M, García-Bragado F, Rabuñal R, Boccalon H, Trujillo-Santos J, Monreal M, Abstract Long-term therapy with low-molecular-weight heparin (LMWH) is the treatment of choice for cancer patients with venous thromboembolism (VTE). However, the ideal doses of LMWH have not been thoroughly studied. We used the RIETE Registry data to assess the influence of the daily LMWH dosage on outcome during the first three months after VTE. We used propensity score-matching to compare patients who received <150 vs. those receiving ≥150 UI/kg/day LMWH. Up to July 2010, 3,222 cancer patients with VTE received long-term therapy with fixed doses of LMWH. Of these, 1,472 (46%) received <150 IU/kg/day (mean, 112 ± 28), and 1,750 received ≥150 IU/kg/day (mean... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5463789 Thu, 24 Nov 2011 05:00:00 +0100 5463789 http://www.medworm.com/index.php?rid=5463788&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22116520%26dopt%3DAbstract In conclusion, the data reported in our study clearly highlight the participation of IL-10 in inhibitors formation in Chinese HA patients. PMID: 22116520 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5463788 Thu, 24 Nov 2011 05:00:00 +0100 5463788 http://www.medworm.com/index.php?rid=5463787&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22116556%26dopt%3DAbstract Authors: Cramer TJ, Gale AJ Abstract Almost two decades ago an anticoagulant function of factor V (FV) was discovered, as an anticoagulant cofactor for activated protein C (APC). A natural mutant of FV in which the R506 inactivation site was mutated to Gln (FVLeiden) was inactivated slower by APC, but also could not function as anticoagulant cofactor for APC in the inactivation of activated factor VIII (FVIIIa). This mutation is prevalent in populations of Caucasian descent, and increases the chance of thrombotic events in carriers. Characterisation of the FV anticoagulant effect has elucidated multiple properties of the anticoagulant function of FV: 1) Cleavage of FV at position 506 by APC is required for anticoagulant function. 2) The C-terminal part of the FV B domain is require... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5463787 Thu, 24 Nov 2011 05:00:00 +0100 5463787 http://www.medworm.com/index.php?rid=5463786&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22116592%26dopt%3DAbstract Authors: Orlando C, Lissens W, Hasaerts D, Jochmans K PMID: 22116592 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5463786 Thu, 24 Nov 2011 05:00:00 +0100 5463786 http://www.medworm.com/index.php?rid=5463785&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22116617%26dopt%3DAbstract In this study, we describe a NAIT case caused by maternal alloimmunisation against a new antigen on αIIbβ3. Analysis with mutant transfected cells showed that the Lys580Asn mutation responsible for the formation of the Seca antigenic determinant affects αIIbβ3 receptor function. PMID: 22116617 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5463785 Thu, 24 Nov 2011 05:00:00 +0100 5463785 http://www.medworm.com/index.php?rid=5428370&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22071772%26dopt%3DAbstract Authors: Profumo E, Buttari B, Petrone L, Straface E, Gambardella L, Pietraforte D, Genuini I, Capoano R, Salvati B, Malorni W, Riganò R Abstract Oxidative stress and immune/inflammatory responses are key pathogenetic factors of atherosclerotic disease. In this contest, mechanisms that regulate survival and death of immune cells may be relevant. Previous studies have demonstrated that red blood cells (RBCs) are physiologically able to inhibit apoptosis and to promote proliferation of activated T lymphocytes from healthy subjects. The aim of the present study was to evaluate whether RBCs from patients with carotid atherosclerosis maintain their property to modulate T cell homeostasis. Peripheral blood lymphocytes (PBLs) obtained from healthy subjects were activated in vitro by phyt... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5428370 Thu, 10 Nov 2011 05:00:00 +0100 5428370 http://www.medworm.com/index.php?rid=5428369&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22071880%26dopt%3DAbstract Authors: Ogawa S, Szlam F, Ohnishi T, Molinaro RJ, Hosokawa K, Tanaka KA Abstract Prothrombin complex concentrates (PCCs) and fresh-frozen plasma (FFP) have been clinically used for acute warfarin reversal. The recovery of prothrombin time (PT) or international normalised ratio (INR) is often reported as an endpoint, but haemostatic efficacies of PCCs and FFP may not be fully reflected in static clotting test in platelet-poor plasma. Using various in vitro assays, we compared the effects of two PCC preparations (3-factor PCC; Bebulin and 4-factor PCC; Beriplex) and FFP on warfarin reversal under static and flow conditions. First, we added an aliquot of either PCC (0.3 or 0.72 U/ml) or 20% FFP (v/v) to commercial warfarin plasma (INR 3.2, or 10.3), and then measured PT, factor II, f... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5428369 Thu, 10 Nov 2011 05:00:00 +0100 5428369 http://www.medworm.com/index.php?rid=5428368&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22071958%26dopt%3DAbstract Authors: Kuijpers MJ, Megens RT, Nikookhesal E, Feijge MA, De Mey JG, Oude Egbrink MG, van Giezen JJ, Heemskerk JW Abstract Platelet P2Y12 receptors play an important role in arterial thrombosis by stimulating thrombus growth. Both irreversibly (clopidogrel) and reversibly binding (ticagrelor, AZD6140) P2Y12 antagonists are clinically used for restricted periods, but possible differences in platelet function recovery after drug cessation have not been investigated. We treated WKY rats with a single, high dose of 200 mg/kg clopidogrel or 40 mg/kg ticagrelor. Blood was collected at different time points after treatment. Flow cytometry confirmed full platelet protection against ADP-induced αIIbβ3 activation shortly after clopidogrel or ticagrelor treatment. At later time points afte... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5428368 Thu, 10 Nov 2011 05:00:00 +0100 5428368 http://www.medworm.com/index.php?rid=5428367&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22072012%26dopt%3DAbstract Authors: Clauser S, Meilhac O, Bieche I, Raynal P, Bruneval P, Michel JB, Borgel D Abstract Vitamin K-dependent protein Gas6 (growth-arrest specific gene 6) plays a role in vascular smooth muscle cell (VSMC) survival and migration, as well as in endothelium and leukocyte activation, and could therefore be involved in atherosclerosis. However, the study of mouse models has led to contradictory results regarding the pro- or anti-atherogenic properties of Gas6, and relatively few data are available in human pathophysiology. To better understand the implication of Gas6 in human atherosclerosis, we studied Gas6 expression and secretion in vitro in human VSMC, and analysed the effect of Gas6 on inflammatory gene expression in these cells. We show that Gas6 secretion in VSMC is strongly ... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5428367 Thu, 10 Nov 2011 05:00:00 +0100 5428367 http://www.medworm.com/index.php?rid=5428366&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22072054%26dopt%3DAbstract Authors: de Gaetano M, Quacquaruccio G, Di Castelnuovo A, Nowak N, Dorn J, Donati MB, Freudenheim JL, Trevisan M, Iacoviello L PMID: 22072054 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5428366 Thu, 10 Nov 2011 05:00:00 +0100 5428366 http://www.medworm.com/index.php?rid=5428365&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22072088%26dopt%3DAbstract In conclusion, pre-formed anti-PF4/heparin antibodies are common in patients undergoing cardiac surgery, but the available literature does not support that they predict postoperative thromboembolic complications or death. There does appear to be an association between anti-PF4/heparin antibodies and non-thromboembolic adverse events, but a causal relationship is unlikely. PMID: 22072088 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5428365 Thu, 10 Nov 2011 05:00:00 +0100 5428365 http://www.medworm.com/index.php?rid=5428364&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22072136%26dopt%3DAbstract Authors: Kobsar A, Siauw C, Gambaryan S, Hebling S, Speer C, Schubert-Unkmeir A, Eigenthaler M Abstract Despite antibiotic therapy, infections with Neisseria meningitidis still demonstrate a high rate of morbidity and mortality even in developed countries. The fulminant septicaemic course, named Waterhouse-Friderichsen syndrome, with massive haemorrhage into the adrenal glands and widespread petechial bleeding suggest pathophysiological inhibition of platelet function. Our data show that N. meningitidis produces the important physiological platelet inhibitor and cardiovascular signalling molecule nitric oxide (NO), also known as endothelium-derived relaxing factor (EDRF). N. meningitidis -derived NO inhibited ADP-induced platelet aggregation through the activation of soluble guanyl... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5428364 Thu, 10 Nov 2011 05:00:00 +0100 5428364 http://www.medworm.com/index.php?rid=5428363&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22072215%26dopt%3DAbstract In conclusion, despite the low incidence of DVT/PE in Asian patients with loco-regional CRC, the protective effect of Asian ethnicity on VTE development disappears as tumour stage increases in patients with distant metastases. Considering different clinical characteristics and prognostic influences between DVT/PE and IVT, the treatment approach should be also different. PMID: 22072215 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5428363 Thu, 10 Nov 2011 05:00:00 +0100 5428363 http://www.medworm.com/index.php?rid=5428362&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22072231%26dopt%3DAbstract Authors: Wildhagen KC, Lutgens E, Loubele ST, Ten Cate H, Nicolaes GA Abstract Protein C is the central enzyme of the natural anticoagulant pathway and its activated form APC (activated protein C) is able to proteolyse non-active as well as active coagulation factors V and VIII. Proteolysis renders these cofactors inactive, resulting in an attenuation of thrombin formation and overall down-regulation of coagulation. Presences of the APC cofactor, protein S, thrombomodulin, endothelial protein C receptor and a phospholipid surface are important for the expression of anticoagulant APC activity. Notably, APC also has direct cytoprotective effects on cells: APC is able to protect the endothelial barrier function and expresses anti-inflammatory and anti-apoptotic activities. Exact molec... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5428362 Thu, 10 Nov 2011 05:00:00 +0100 5428362 http://www.medworm.com/index.php?rid=5428361&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22072287%26dopt%3DAbstract Authors: Manzano-Fernandez S, Cambronero F, Caro-Martínez C, Hurtado-Martínez JA, Marín F, Pastor-Pérez FJ, Mateo-Martínez A, Sánchez-Martínez M, Pinar-Bermudez E, Valdés M Abstract Bleeding risk is increased in patients with atrial fibrillation (AF) and moderate to severe kidney disease (KD); however, the implication of mild KD on bleeding remains unclear. The aim of this study was to determine whether the presence of mild KD increases risk for major bleeding (MB) in patients with AF undergoing percutaneous coronary intervention with stent implantation (PCI-S). Two hundred eighty-five patients were included. Patients were classified into three kidney function groups: moderate to severe KD (n=91; <60 ml/min/1.73 m²), mild KD (n=139; 60-89 ml/min/1.73 m²) and non-KD (n=... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5428361 Thu, 10 Nov 2011 05:00:00 +0100 5428361 http://www.medworm.com/index.php?rid=5428360&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22072293%26dopt%3DAbstract In conclusion, irrespective of which CDR is used, the age-adjusted D-dimer substantially increases the number of patients above 50 years in whom PE can be safely excluded. PMID: 22072293 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5428360 Thu, 10 Nov 2011 05:00:00 +0100 5428360 http://www.medworm.com/index.php?rid=5383588&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22048744%26dopt%3DAbstract Authors: Kirchhof P, Lip GY, Van Gelder IC, Bax J, Hylek E, Kaab S, Schotten U, Wegscheider K, Boriani G, Ezekowitz M, Diener H, Heidbuchel H, Lane D, Mont L, Willems S, Dorian P, Vardas P, Breithardt G, Camm AJ Abstract There are exciting new developments in several areas of atrial fibrillation (AF) management that carry the hope of improving outcomes in AF patients. This paper is an executive summary that summarises the proceedings from the 3rd AFNET/EHRA consensus conference on atrial fibrillation, held in Sophia Antipolis from November 7th to 9th 2010, shortly after the release of the new ESC guidelines on AF. The conference was jointly organised by the German Atrial Fibrillation competence NETwork (AFNET) and the European Heart Rhythm Association (EHRA). This executive summary... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5383588 Wed, 02 Nov 2011 04:00:00 +0100 5383588 http://www.medworm.com/index.php?rid=5383587&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22048796%26dopt%3DAbstract Authors: Lip GY, Andreotti F, Fauchier L, Huber K, Hylek E, Knight E, Lane D, Levi M, Marín F, Palareti G, Kirchhof P Abstract In this executive summary of a Consensus Document from the European Heart Rhythm Association, endorsed by the European Society of Cardiology Working Group on Thrombosis, we comprehensively review the published evidence and propose a consensus on bleeding risk assessments in atrial fibrillation (AF) patients. The main aim of the document was to summarise 'best practice' in dealing with bleeding risk in AF patients when approaching antithrombotic therapy, by addressing the epidemiology and size of the problem, and review established bleeding risk factors. We also summarise definitions of bleeding in the published literature. Patient values and preferences ba... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5383587 Wed, 02 Nov 2011 04:00:00 +0100 5383587 http://www.medworm.com/index.php?rid=5348367&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22011700%26dopt%3DAbstract Authors: Lutgens E, Binder CJ PMID: 22011700 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5348367 Thu, 20 Oct 2011 04:00:00 +0100 5348367 http://www.medworm.com/index.php?rid=5348366&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22011848%26dopt%3DAbstract In conclusion, TSP-4, a matricellular protein involved in regulating vascular inflammation, plays a role in establishing recurrent coronary risk in post-infarction patients with high levels of HDL-C and CRP. Further studies should focus on additional effects of vascular inflammatory processes on anti-atherogenic functionality of HDL particles. PMID: 22011848 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5348366 Thu, 20 Oct 2011 04:00:00 +0100 5348366 http://www.medworm.com/index.php?rid=5348365&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22011914%26dopt%3DAbstract In conclusion, a considerable proportion of elderly patients exhibit HPR while on standard clopidogrel therapy. Switching to 5 mg/day prasugrel in elderly patients with HPR is associated with enhanced platelet inhibition and overcomes HPR in the majority of these patients. PMID: 22011914 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5348365 Thu, 20 Oct 2011 04:00:00 +0100 5348365 http://www.medworm.com/index.php?rid=5348364&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22012002%26dopt%3DAbstract Authors: de Jager SC, Kuiper J Abstract The treatment of atherosclerosis is currently based on lipid lowering in combination with anti-inflammatory therapies that slow the progression of atherosclerosis. Still, we are not able to fully inhibit the formation or progression of atherosclerotic lesions. A very effective strategy in other disease pathologies is vaccination, in which the body is challenged with the culprit protein or micro-organism in order to create a highly specific humoral immune-response. Immunisation can typically be divided into active or passive immunisation. Active immunisation occurs naturally when the body is exposed to certain microbes or antigens, but also artificially in the case of vaccination. Exposure to a microbe or antigen will result in the production ... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5348364 Thu, 20 Oct 2011 04:00:00 +0100 5348364 http://www.medworm.com/index.php?rid=5348363&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22012070%26dopt%3DAbstract Authors: Furugohri T, Sugiyama N, Morishima Y, Shibano T Abstract There is increasing concern that some anticoagulants can paradoxically increase thrombogenesis under certain circumstances. Previously, we demonstrated that at certain doses a direct thrombin inhibitor, melagatran, worsens the coagulation status induced by tissue factor (TF) injection in a rat model. We utilised an in vitro thrombin generation (TG) assay to determine if direct thrombin inhibitors could enhance TG in human plasma, and whether inhibition of the negative-feedback system [thrombin-thrombomodulin (TM)-protein C] contributed to the TG enhancement. TG in human plasma was assayed by means of the calibrated automated thrombography. In this assay, direct factor Xa (FXa) inhibitors such as edoxaban and antithro... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5348363 Thu, 20 Oct 2011 04:00:00 +0100 5348363 http://www.medworm.com/index.php?rid=5348362&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22012133%26dopt%3DAbstract Authors: Rosenfeld ME, Campbell LA Abstract It is currently unclear what causes the chronic inflammation within atherosclerotic plaques. One emerging paradigm suggests that infection with bacteria and/or viruses can contribute to the pathogenesis of atherosclerosis either via direct infection of vascular cells or via the indirect effects of cytokines or acute phase proteins induced by infection at non-vascular sites. This paradigm has been supported by multiple epidemiological studies that have established positive associations between the risk of cardiovascular disease morbidity and mortality and markers of infection. It has also been supported by experimental studies showing an acceleration of the development of atherosclerosis following infection of hyperlipidaemic animal models... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5348362 Thu, 20 Oct 2011 04:00:00 +0100 5348362 http://www.medworm.com/index.php?rid=5348361&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22012181%26dopt%3DAbstract In conclusion, dialysis patients have clearly elevated risks of venous thrombosis and arterial thrombosis and occurrence of venous thrombosis or arterial thrombosis prior to the start of dialysis is associated with an increased mortality risk. PMID: 22012181 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5348361 Thu, 20 Oct 2011 04:00:00 +0100 5348361 http://www.medworm.com/index.php?rid=5348360&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22012244%26dopt%3DAbstract In conclusion, in thoracic surgery patients, switching from enoxaparin to fondaparinux to prevent VTE was associated with a significant increase in the risk of postoperative major bleeding. A causal relationship appears plausible. PMID: 22012244 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5348360 Thu, 20 Oct 2011 04:00:00 +0100 5348360 http://www.medworm.com/index.php?rid=5348359&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22012299%26dopt%3DAbstract Authors: Zondag W, Agterof MJ, Schutgens RE, Dekkers OM, Biesma DH, Huisman MV PMID: 22012299 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5348359 Thu, 20 Oct 2011 04:00:00 +0100 5348359 http://www.medworm.com/index.php?rid=5348358&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22012325%26dopt%3DAbstract In conclusion, patients with atherosclerosis and VTE are more likely to suffer a complicated hospital course. Despite a high frequency of comorbid conditions contributing to the risk of VTE, we observed a low rate of thromboprophylaxis in patients with symptomatic atherosclerosis. PMID: 22012325 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5348358 Thu, 20 Oct 2011 04:00:00 +0100 5348358 http://www.medworm.com/index.php?rid=5348357&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22012406%26dopt%3DAbstract Authors: Drechsler M, Döring Y, Megens RT, Soehnlein O Abstract Neutrophils, as part of the innate immune system, are classically described to be main actors during the onset of inflammation enforcing rapid neutralisation and clearance of pathogens. Besides their well-studied role in acute inflammatory processes, recent advances strongly indicate a so far underappreciated importance of neutrophils in initiation and development of atherosclerosis. This review focuses on current findings on the role of neutrophils in atherosclerosis. As pro-inflammatory mechanisms of neutrophils have primarily been studied in the microvascular environment; we here aim at translating these into the context of macrovascular inflammation in atherosclerosis. Since much of the pro-inflammatory activities... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5348357 Thu, 20 Oct 2011 04:00:00 +0100 5348357 http://www.medworm.com/index.php?rid=5348356&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22012481%26dopt%3DAbstract In conclusion, VTE is common in Asian hospitalised medical patients. Patients with autoimmune disease and those with solid tumours are highly susceptible to VTE. A prophylactic strategy in these groups is required. PMID: 22012481 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5348356 Thu, 20 Oct 2011 04:00:00 +0100 5348356 http://www.medworm.com/index.php?rid=5348355&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22012554%26dopt%3DAbstract The objective of this review is to update and discuss the current perceptions of the platelet immune constituents and their prospect as therapeutic targets in an atherosclerotic setting. PMID: 22012554 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5348355 Thu, 20 Oct 2011 04:00:00 +0100 5348355 http://www.medworm.com/index.php?rid=5348354&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22012581%26dopt%3DAbstract Should we focus on "venous vulnerability" instead of "plaque vulnerability" in symptomatic atherosclerotic patients? Thromb Haemost. 2011 Oct 20;106(6) Authors: Montecucco F, Mach F PMID: 22012581 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5348354 Thu, 20 Oct 2011 04:00:00 +0100 5348354 http://www.medworm.com/index.php?rid=5348353&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22012630%26dopt%3DAbstract Authors: Cuker A PMID: 22012630 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5348353 Thu, 20 Oct 2011 04:00:00 +0100 5348353 http://www.medworm.com/index.php?rid=5348375&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21979058%26dopt%3DAbstract Authors: Ketelhuth DF, Hansson GK Abstract Atherosclerosis is a chronic inflammatory disease. Atherosclerotic plaques contain abundant immune cells that can dictate and effect inflammatory responses. Among them, T cells are present during all stages of the disease suggesting that they are essential in the initiation as well as the progression of plaque. Experimental as well as clinical research has demonstrated different T cell subsets, i.e. CD4+ Th1, Th2, Th17, and Treg as well as CD8+ and NKT cells in the plaque. Moreover, candidate antigens inducing T cell responses have been identified. Knowledge about the pathological role of these cells in atherogenesis may lead to development of new therapies. This review provides an overview of the research field of cellular immunity in ath... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5348375 Thu, 06 Oct 2011 04:00:00 +0100 5348375 http://www.medworm.com/index.php?rid=5348374&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21979131%26dopt%3DAbstract Authors: Wade NS, Major AS Abstract Rheumatic autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus (SLE), are associated with antibodies to "self" antigens. Persons with autoimmune diseases, most notably SLE, are at increased risk for developing accelerated cardiovascular disease. The link between immune and inflammatory responses in the pathogenesis of cardiovascular disease has been firmly established; yet, despite our increasing knowledge, accelerated atherosclerosis continues to be a significant co-morbidity and cause of mortality in SLE. Recent animal models have been generated in order to identify mechanism(s) behind SLE-accelerated atherosclerosis. In addition, clinical studies have been designed to examine potential treatments options. This rev... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5348374 Thu, 06 Oct 2011 04:00:00 +0100 5348374 http://www.medworm.com/index.php?rid=5348373&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21979237%26dopt%3DAbstract In conclusion, a newly developed lateral-flow assay, LFI-HIT, was capable of identifying all HIT patients in a cohort in a short period of time. Beside an NPV of 100%, the rate of false-positive signals is significantly lower with LFI-HIT than with other immunoassay(s). These performance characteristics suggest a high potency in reducing the risk and costs in patients suspected of having HIT. PMID: 21979237 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5348373 Thu, 06 Oct 2011 04:00:00 +0100 5348373 http://www.medworm.com/index.php?rid=5348372&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21979291%26dopt%3DAbstract Authors: Ahmad S, Ptashkin B, Digiovanni C, Cines DB, Konkle BA, Cuker A PMID: 21979291 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5348372 Thu, 06 Oct 2011 04:00:00 +0100 5348372 http://www.medworm.com/index.php?rid=5348371&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21979378%26dopt%3DAbstract In conclusion, although diabetes is associated with multiple abnormalities of coagulation, anticoagulation and fibrinolysis, these changes are not detectable when superimposed on the background of larger abnormalities attributable to B. pseudomallei sepsis. PMID: 21979378 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5348371 Thu, 06 Oct 2011 04:00:00 +0100 5348371 http://www.medworm.com/index.php?rid=5348370&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21979444%26dopt%3DAbstract Authors: Gerdes N, Zirlik A Abstract A plethora of basic laboratory and clinical studies has uncovered the chronic inflammatory nature of atherosclerosis. The adaptive immune system with its front-runner, the T cell, drives the atherogenic process at all stages. T cell function is dependent on and controlled by a variety of either co-stimulatory or co-inhibitory signals. In addition, many of these proteins enfold T cell-independent pro-atherogenic functions on a variety of cell types. Accordingly they represent potential targets for immune-modulatory and/or anti-inflammatory therapy of atherosclerosis. This review focuses on the diverse role of co-stimulatory molecules of the B7 and tumour necrosis factor (TNF)-superfamily and their downstream signalling effectors in atherosclerosi... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5348370 Thu, 06 Oct 2011 04:00:00 +0100 5348370 http://www.medworm.com/index.php?rid=5348369&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21979864%26dopt%3DAbstract Authors: Siller-Matula JM, Schwammeis M, Blann A, Mannhalter C, Jilma B Abstract Thrombin is the central protease in the coagulation cascade and one of the most extensively studied of all enzymes. In addition to its recognised role in the coagulation cascade and haemostasis, thrombin is known to have multiple pleiotropic effects, which mostly have been shown only in in vitro studies: it plays a role in inflammation and cellular proliferation and displays a mitogen activity on smooth muscle cells and endothelial cells, predominantly by activation of angiogenesis. In vivo , thrombin effects were examined in animal models of intravenous or intraarterial thrombin infusion. An extensive literature search regarding in vivo data showed that i) thrombin administered as a bolus causes micro... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5348369 Thu, 06 Oct 2011 04:00:00 +0100 5348369 http://www.medworm.com/index.php?rid=5348368&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21979881%26dopt%3DAbstract In conclusion, pregnancy induces a decrease of TFPIfree and protein Sfree levels that attenuates the function of the TFPI and protein C systems and results in elevated thrombin generation and increased APC resistance. Besides, our data suggest that pregnancy-dependent haemodilution may contribute to the decreased peripheral protein S levels. PMID: 21979881 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5348368 Thu, 06 Oct 2011 04:00:00 +0100 5348368 http://www.medworm.com/index.php?rid=5284351&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21736699%26dopt%3DAbstract Authors: Stratta P, Canavese C, Cena T, Quaglia M, Pergolini P, Bellomo G, Magnani C Abstract See also Roeters van Lennep JE, Meijer E, Klumper FJ, Middeldorp JM, Bloemenkamp KW, Middeldorp S. Prophylaxis with low-dose low-molecular-weight-heparin during pregnancy and postpartum: is it effective? J Thromb Haemost 2011; 9: 473-80; Roeters van Lennep JE, Meijer E, Klumper FJCM, Middeldorp JM, Bloemenkamp KWM, Middeldorp S. Low-molecular-weight-heparin and pregnancy, when the dose does it: a nephrologist's opinion: reply to a rebuttal. This issue, pp 2129-30. PMID: 21736699 [PubMed - in process] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5284351 Sat, 01 Oct 2011 04:00:00 +0100 5284351 http://www.medworm.com/index.php?rid=5284350&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21762466%26dopt%3DAbstract Authors: Roeters VAN Lennep JE, Meijer E, Klumper FJ, Middeldorp JM, Bloemenkamp KW, Middeldorp S Abstract See also Roeters van Lennep JE, Meijer E, Klumper FJ, Middeldorp JM, Bloemenkamp KW, Middeldorp S. Prophylaxis with low-dose low-molecular-weight-heparin during pregnancy and postpartum: is it effective? J Thromb Haemost 2011; 9: 473-80; Stratta P, Canavese C, Cena T, Quaglia M, Pergolini P, Bellomo G, Magnani C. Low-molecular-weight-heparin and pregnancy, when the dose does it: a nephrologist's opinion: a rebuttal. This issue, pp 2127-9. PMID: 21762466 [PubMed - in process] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5284350 Sat, 01 Oct 2011 04:00:00 +0100 5284350 http://www.medworm.com/index.php?rid=5284349&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21762467%26dopt%3DAbstract Authors: Tripodi A, Pengo V Abstract See also Favaloro EJ, Bonar R, Zebeljan D, Kershaw G, Marsden K. Laboratory investigation of lupus anticoagulants: mixing studies are sometimes required. J Thromb Haemost 2010; 8: 2828-31. PMID: 21762467 [PubMed - in process] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5284349 Sat, 01 Oct 2011 04:00:00 +0100 5284349 http://www.medworm.com/index.php?rid=5284372&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21833448%26dopt%3DAbstract In conclusion, despite demonstrated efficacy and established guidelines supporting VTE prophylaxis, utilisation rates and treatment duration remain suboptimal, leaving medical patients at continued risk for VTE. Improved guideline adherence and effective care delivery among the medically ill are stressed. PMID: 21833448 [PubMed - in process] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5284372 Tue, 27 Sep 2011 04:00:00 +0100 5284372 http://www.medworm.com/index.php?rid=5284371&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21901227%26dopt%3DAbstract Authors: Honickel M, Rieg A, Rossaint R, Braunschweig T, Spronk HM, Ten Cate H, van Oerle R, Tolba R, Grottke O Abstract Although prothrombin complex concentrate (PCC) is increasingly used for the treatment of trauma-induced coagulopathy, few studies have investigated the impact and safety of PCC for this indication. The present study was performed to assess PCC for treatment of coagulopathy after blunt liver injury under severe hypothermia. Coagulopathy in 14 anaesthetised pigs was induced by haemodilution. Subsequently, standardised blunt liver injury was induced under severe hypothermia (32.8-33.2°C). Animals were randomised to receive either PCC (35 IU kg⁻¹) or saline (control). Coagulation was assessed over the following 2 hours by thromboelastometry and thrombin generatio... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5284371 Tue, 27 Sep 2011 04:00:00 +0100 5284371 http://www.medworm.com/index.php?rid=5284370&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21901229%26dopt%3DAbstract Authors: Lobo JL, Nieto JA, Zorrilla V, Garrido N, Madridano O, Ruiz J, Farge-Bancel D, Tiberio G, Uresandi F, Monreal M, PMID: 21901229 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5284370 Tue, 27 Sep 2011 04:00:00 +0100 5284370 http://www.medworm.com/index.php?rid=5284369&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21901231%26dopt%3DAbstract Authors: Guella I, Duga S, Ardissino D, Merlini PA, Peyvandi F, Mannucci PM, Asselta R Abstract Occlusive coronary thrombus formation superimposed on an atherosclerotic plaque is the ultimate event leading to myocardial infarction (MI). Therefore, haemostatic proteins may represent important players in the pathogenesis of MI. It was the objective of this study to evaluate, in a comprehensive way, the role of haemostatic gene polymorphisms in predisposition to premature MI. A total of 810 single nucleotide polymorphisms (SNPs) in 37 genes were assessed for association with MI in a large cohort (1,670 males, 210 females) of Italian patients who suffered from an MI event before the age of 45, and an equal number of controls. Thirty-eight SNPs selected from the literature were genotype... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5284369 Tue, 27 Sep 2011 04:00:00 +0100 5284369 http://www.medworm.com/index.php?rid=5284368&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21901232%26dopt%3DAbstract In conclusion, NN1731 was a greater potential than rFVIIa in up-regulating FVIII activity, and the TF-independent FVIII activation might represent a potential extra mode of its enhanced haemostatic effect. PMID: 21901232 [PubMed - in process] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5284368 Tue, 27 Sep 2011 04:00:00 +0100 5284368 http://www.medworm.com/index.php?rid=5284359&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21947061%26dopt%3DAbstract Authors: Castilloux JF, Moffat KA, Liu Y, Seecharan J, Pai M, Hayward CP Abstract Light transmission platelet aggregometry (LTA) is important to diagnose bleeding disorders. Experts recommend testing LTA with native (N) rather than platelet count adjusted (A) platelet-rich plasma (PRP), although it is unclear if this provides non-inferior, or superior, detection of bleeding disorders. Our goal was to determine if LTA with NPRP is non-inferior to LTA with APRP for bleeding disorder assessments. A prospective cohort of patients, referred for bleeding disorder testing, and healthy controls, were evaluated by LTA using common agonists, NPRP and APRP (adjusted to 250 x 109 platelets/l). Recruitment continued until 40 controls and 40 patients with definite bleeding disorders were tested.... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5284359 Tue, 27 Sep 2011 04:00:00 +0100 5284359 http://www.medworm.com/index.php?rid=5284367&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21946866%26dopt%3DAbstract Authors: Getz GS, Vanderlaan PA, Reardon CA Abstract Cells of both the innate and adaptive immune system participate in the development of atherosclerosis, a chronic inflammatory disorder of medium and large arteries. Natural killer T (NKT) cells express surface markers characteristic of natural killer cells and conventional T cells and bridge the innate and adaptive immune systems. The development and activation of NKT cells is dependent upon CD1d, a MHC-class I-type molecule that presents lipids, especially glycolipids to the T cell receptors on NKT cells. There are two classes of NKT cells; invariant NKT cells that express a semi-invariant T cell receptor and variant NKT cells. This review summarises studies in murine models in which the effect of the activation, overexpression ... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5284367 Thu, 22 Sep 2011 04:00:00 +0100 5284367 http://www.medworm.com/index.php?rid=5284366&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21946915%26dopt%3DAbstract Authors: Gris JC, Chauleur C, Molinari N, Marès P, Fabbro-Peray P, Quere I, Lefrant JY, Haddad B, Dauzat M Abstract Administration of heparin in the secondary prevention of placental vascular complications is still experimental. In women with a previous severe pre-eclampsia, we investigated the effectiveness of enoxaparin, a low-molecular-weight heparin, in preventing these complications. Between January 2000 and January 2010, 224 women from the NOHA First cohort, with previous severe pre-eclampsia but no foetal loss during their first pregnancy and negative for antiphospholipid antibodies, were randomised to either a prophylactic daily dose of enoxaparin starting from the positive pregnancy test (n=112), or no enoxaparin (n=112). The primary outcome was a composite of at least on... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5284366 Thu, 22 Sep 2011 04:00:00 +0100 5284366 http://www.medworm.com/index.php?rid=5284365&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21946932%26dopt%3DAbstract Authors: Butcher M, Galkina E Abstract Multiple components of the immune response are involved in the initiation, progression and persistence of atherosclerosis. Interleukin (IL)-17A is produced by a broad variety of leukocytes and plays an important role in host defense. IL-17A is also involved in the pathology of several autoimmune diseases mainly via the regulation of chemokine expression and leukocyte migration to the site of inflammation. There is an increasing body of evidence indicating an association between elevated levels of IL-17A and cardiovascular diseases. Interestingly, this IL-17A-dependent response occurs in parallel with the Th1-dominant immune response during atherogenesis. To date, the precise role of IL-17A+ cells in atherosclerosis is controversial. Several st... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5284365 Thu, 22 Sep 2011 04:00:00 +0100 5284365 http://www.medworm.com/index.php?rid=5284364&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21946939%26dopt%3DAbstract In this report members of the board of the Italian Federation of Thrombosis Centers (FCSA) answer some questions every clinician might be confronted with. PMID: 21946939 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5284364 Thu, 22 Sep 2011 04:00:00 +0100 5284364 http://www.medworm.com/index.php?rid=5284363&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21946947%26dopt%3DAbstract In this study, we report that a potent antiplatelet agent, 2-ethylthio-6-phenethylaminoadenosine (BF061), inhibits platelet activation and thrombosis via P2Y12 antagonism and PDE inhibition. We explored the antiplatelet mechanism of BF061 by measuring cAMP, cGMP levels, PDE activity, and the interaction between ADP and P2Y12 using atomic force microscopy. The antithrombotic effect of BF061 was evaluated in mice using intravital microscopy in FeCl3-induced mesenteric and laser-induced cremasteric arterial thrombosis models. BF061 robustly inhibited platelet aggregation and ATP release induced by multiple platelet agonists via P2Y12 antagonism and PDE inhibition. Interestingly, despite being structurally similar to BF061, P2Y12 receptor antagonist AR-C69931MX had no effect on human platelet ... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5284363 Thu, 22 Sep 2011 04:00:00 +0100 5284363 http://www.medworm.com/index.php?rid=5284362&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21946952%26dopt%3DAbstract This study compared the antithrombotic efficacy of edoxaban with that of an indirect FXa inhibitor, fondaparinux, on in vivo venous and arterial thrombosis models and on ex vivo perfusion chamber thrombosis model under low and high shear rates in rats. Venous and arterial thrombi were induced by platinum wire insertion into the inferior vena cava and by application of FeCl3 to the carotid artery, respectively. The perfusion chamber thrombus was formed by blood perfusion into a collagen-coated capillary at 150 s⁻¹ (low shear rate) and 1,600 s⁻¹ (high shear rate). Effective doses of edoxaban that reduced thrombus formation by 50% (ED50) in venous and arterial thrombosis models were 0.076 and 0.093 mg/kg/h, respectively. In contrast, ED50 of fondaparinux in the arterial thrombosis mode... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5284362 Thu, 22 Sep 2011 04:00:00 +0100 5284362 http://www.medworm.com/index.php?rid=5284361&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21946984%26dopt%3DAbstract Authors: Gris JC, Bouvier S, Cochery-Nouvellon E, Faillie JL, Lissalde-Lavigne G, Lefrant JY PMID: 21946984 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5284361 Thu, 22 Sep 2011 04:00:00 +0100 5284361 http://www.medworm.com/index.php?rid=5284360&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21947024%26dopt%3DAbstract Authors: Apostolakis S, Lip GY PMID: 21947024 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5284360 Thu, 22 Sep 2011 04:00:00 +0100 5284360 http://www.medworm.com/index.php?rid=5284358&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21947196%26dopt%3DAbstract In conclusion, inhibition of IL-1 activity by anakinra reduces apoptotic markers leading to improved LV performance in RA. PMID: 21947196 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5284358 Thu, 22 Sep 2011 04:00:00 +0100 5284358 http://www.medworm.com/index.php?rid=5284357&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21947221%26dopt%3DAbstract In conclusion, women with moderate or severe VWD frequently have menorrhagia in need of treatment, and 20% of the VWD women underwent a hysterectomy. Bleeding complications occurred in over 50% of the women after childbirth or pregnancy loss. Progeny seems not to be affected in women with moderate or severe VWD. PMID: 21947221 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5284357 Thu, 22 Sep 2011 04:00:00 +0100 5284357 http://www.medworm.com/index.php?rid=5284356&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21947241%26dopt%3DAbstract We examined the role of this interaction in the generation of tenase activity during the process of clot formation, using a synthetic peptide corresponding to residues 2228-2240. The peptide 2228-2240 inhibited FVIIIa/FIXa-mediated FX activation dose-dependently in the presence of PL by >95% (IC50; ~10 μM). This effect was significantly greater than that obtained by peptide 1804-1818 (IC50; ~180 μM) which corresponds to another FIXa-interactive site in the light chain that provides the majority of binding energy for FIXa interaction. Peptide 2228-2240 had little effect on the prothrombin time and did not inhibit FIX activation in the coagulation process mediated by FVIIa/tissue factor or FXIa, suggesting specific inhibition of the intrinsic tenase complex. Clot waveform analysis, a pl... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5284356 Thu, 22 Sep 2011 04:00:00 +0100 5284356 http://www.medworm.com/index.php?rid=5284355&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21947267%26dopt%3DAbstract In conclusion, high thrombin generation in the presence of APC, in women after a first event of VTE is indicative for an increased risk of a recurrence. We also found that thrombin generation at low TF (1 pM) is correlated with the risk of recurrence. Our data suggest that APC resistance in the absence of factor V Leiden is a risk factor for recurrent VTE. PMID: 21947267 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5284355 Thu, 22 Sep 2011 04:00:00 +0100 5284355 http://www.medworm.com/index.php?rid=5284354&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21947303%26dopt%3DAbstract We examined baseline clinical variables associated with a positive SRA in the setting of a positive HIT EIA (OD >0.4). We then used logistic regression to identify baseline clinical variables independently associated with a positive SRA given a positive EIA. The cohort included 99 subjects with positive EIAs and 35% had positive SRAs. An OD>0.40 had moderate utility as a screening test for a positive SRA (AUROC: 0.68; 95% CI: 0.55-0.80). Increasing the OD threshold did not improve the HIT EIA's screening utility. Clinical variables independently associated with a positive SRA if the EIA were positive included female gender, absence of diabetes, and use of cardiopulmonary bypass. A relatively modest elevation in the OD measurement, when it is already known to be greater than 0.4, does... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5284354 Thu, 22 Sep 2011 04:00:00 +0100 5284354 http://www.medworm.com/index.php?rid=5284353&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21947328%26dopt%3DAbstract Authors: Wolfs IM, Donners MM, de Winther MP Abstract The phenotype of macrophages in atherosclerotic lesions can vary dramatically, from a large lipid laden foam cell to a small inflammatory cell. Classically, the concept of macrophage heterogeneity discriminates between two extremes called either pro-inflammatory M1 macrophages or anti-inflammatory M2 macrophages. Polarisation of plaque macrophages is predominantly determined by the local micro-environment present in the atherosclerotic lesion and is rather more complex than typically described by the M1/M2 paradigm. In this review we will discuss the role of various polarising factors in regulating the phenotypical state of plaque macrophages. We will focus on two main levels of phenotype regulation, one determined by differenti... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5284353 Thu, 22 Sep 2011 04:00:00 +0100 5284353 http://www.medworm.com/index.php?rid=5284352&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21947351%26dopt%3DAbstract Authors: Ağar C, de Groot PG, Marquart JA, Meijers JC Abstract β2-Glycoprotein I (β2GPI) is a highly abundant plasma protein and the major antigen for autoantibodies in the antiphospholipid syndrome. Recently, we have described a novel function of β2GPI as scavenger of lipopolysaccharide (LPS). With this in mind we investigated the conservation of β2GPI in vertebrates and set out to identify the binding site of LPS within β2GPI. The genome sequences of 42 species were surveyed. Surface plasmon resonance (SPR) was performed with peptides to characterise the binding site of β2GPI for LPS. β2GPI could be identified in most tested vertebrates with a high overall amino acid homology of 80% or more in mammals. SPR revealed that a synthesised peptide (LAFWKTDA) from domain V of β... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5284352 Thu, 22 Sep 2011 04:00:00 +0100 5284352 http://www.medworm.com/index.php?rid=5221759&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21909592%26dopt%3DAbstract Authors: Huber K, Airaksinen KJ, Cuisset T, Marín F, Rubboli A, Lip GY PMID: 21909592 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5221759 Mon, 12 Sep 2011 04:00:00 +0100 5221759 http://www.medworm.com/index.php?rid=5221762&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21901240%26dopt%3DAbstract Authors: Schouten M, van 't Veer C, Roelofs JJ, Gerlitz B, Grinnell BW, Levi M, van der Poll T Abstract Recombinant human activated protein C (APC), which has both anticoagulant and anti-inflammatory properties, improves survival of patients with severe sepsis. This beneficial effect is especially apparent in patients with pneumococcal pneumonia. Earlier treatment with APC in sepsis has been associated with a better therapeutic response as compared to later treatment. In a mouse model it was recently confirmed that recombinant murine (rm-)APC decreases coagulation activation and improves survival in pneumococcal pneumonia; however, APC did not impact on the inflammatory response. The aim of this study was to determine the effect of APC treatment instigated early in infection on act... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5221762 Thu, 08 Sep 2011 04:00:00 +0100 5221762 http://www.medworm.com/index.php?rid=5221761&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21901241%26dopt%3DAbstract Authors: Hristov M, Weber C Abstract Endothelial dysfunction and inflammation of the arterial wall continuously drive the development of atherosclerosis. Details regarding the sequential involvement of different monocyte subsets in the pathology of this disease have recently emerged. This review concentrates on major monocyte subpopulations in mouse and men and specifically addresses their phenotype, function and recruitment during primary atherosclerosis as well as their contribution to angiogenesis and tissue regeneration secondary to plaque rupture. PMID: 21901241 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5221761 Thu, 08 Sep 2011 04:00:00 +0100 5221761 http://www.medworm.com/index.php?rid=5221760&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21901242%26dopt%3DAbstract Authors: Hayward CP PMID: 21901242 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5221760 Thu, 08 Sep 2011 04:00:00 +0100 5221760 http://www.medworm.com/index.php?rid=5235286&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21924243%26dopt%3DAbstract Authors: Carlsson K, Persson E, Lindgren M, Carlsson U, Svensson M Abstract The apparent length of FVIIa in solution was estimated by a FRET analysis. Two fluorescent probes, fluorescein (Fl-FPR) and a rhodamine derivative (TMR), were covalently attached to FVIIa. The binding site of Fl-FPR was in the protease domain whereas TMR was positioned in the Gla domain, thus allowing a length measure over virtually the whole extension of the protein. From the FRET measurements, the distances between the two probes were determined to be 61.4 for free FVIIa and 65.5Å for FVIIa bound to soluble tissue factor (sTF). These seemingly short distances, compared to those anticipated based on the complex crystal structure, require that the probes stretch towards each other. Thus, the apparent dista... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5235286 Tue, 06 Sep 2011 04:00:00 +0100 5235286 http://www.medworm.com/index.php?rid=5160480&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21866298%26dopt%3DAbstract In conclusion, P-selectin and PMP levels showed positive associations with abnormal carotid IMT and other risk factors in obesity suggesting a critical role of enhanced platelet reactivity in atherosclerotic wall alteration. PMID: 21866298 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5160480 Wed, 24 Aug 2011 23:00:00 +0100 5160480 http://www.medworm.com/index.php?rid=5160479&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21866299%26dopt%3DAbstract Authors: Guasti L, Dentali F, Castiglioni L, Maroni L, Marino F, Squizzato A, Ageno W, Gianni M, Gaudio G, Grandi AM, Cosentino M, Venco A Abstract Some studies have suggested that high levels of total white blood cell (WBC) count and C-reactive protein (CRP) may be considered as independent prognostic factors in patients with acute coronary syndromes (ACS) and/or after cardiac revascularisation by percutaneous coronary intervention or coronary artery bypass grafting surgery. Evidence on the role of neutrophils in cardiovascular disease is less compelling. Therefore, we conducted a systematic review of the literature with the aim of identifying all the available evidence to clarify the role of neutrophils (absolute or relative count, neutrophil/lymphocyte ratio) as a prognostic ris... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5160479 Wed, 24 Aug 2011 23:00:00 +0100 5160479 http://www.medworm.com/index.php?rid=5160478&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21866300%26dopt%3DAbstract Authors: Nayak MK, Singh SK, Roy A, Prakash V, Kumar A, Dash D Abstract Tamoxifen is a known anti-cancer drug and established estrogen receptor modulator. Few clinical studies have earlier implicated the drug in thrombotic complications attributable to lower anti-thrombin and protein S levels in plasma. However, action of tamoxifen on platelet signalling machinery has not been elucidated in detail. In the present report we show that tamoxifen is endowed with significant inhibitory property against human platelet aggregation. From a series of in vivo and in vitro studies tamoxifen was found to inhibit almost all platelet functions, prolong tail bleeding time in mouse and profoundly prevent thrombus formation at injured arterial wall in mice, as well as on collagen matrix perfused wi... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5160478 Wed, 24 Aug 2011 23:00:00 +0100 5160478 http://www.medworm.com/index.php?rid=5160477&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21866301%26dopt%3DAbstract This study was designed to determine whether a prothrombotic state existed in chronic Trypanosoma cruzi -infected patients and, if so, to describe its evolution after treatment with Benznidazole. Twenty-five patients with chronic Chagas disease and 18 controls were evaluated. The markers used were prothrombin time, activated partial thromboplastin time, fibrinogen, antithrombin, plasminogen, protein C, total protein S, free protein S, factor VIII, D-dimer, activated factor VIIa, tissue-type plasminogen activator inhibitor-1, prothrombin fragment 1+2 (F1+2), plasmin-antiplasmin complexes, soluble P-selectinand endogenous thrombin potential (ETP). Despite statistically significant differences between cases and controls in several markers, only ETP (which quantifies the ability of plasma to g... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5160477 Wed, 24 Aug 2011 23:00:00 +0100 5160477 http://www.medworm.com/index.php?rid=5160476&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21866302%26dopt%3DAbstract Authors: Bot I, Biessen EA Abstract The mast cell, a potent inflammatory cell type, is widely distributed over several tissues, but particularly prominent at the interface exposed to the environment to act in the first line of defense against pathogens. Upon activation mast cells release granules, which contain a large panel of mediators, including neutral proteases (e.g. chymase and tryptase), cathepsins, heparin, histamine and a variety of cytokines and growth factors. While mast cells have been demonstrated to be critically involved in a number of Th2 dominated diseases such as asthma and allergy, recent investigations have now also implicated mast cells in the pathogenesis of atherosclerosis and acute cardiovascular syndromes. In this review, we will discuss the contribution of... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5160476 Wed, 24 Aug 2011 23:00:00 +0100 5160476 http://www.medworm.com/index.php?rid=5160475&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21866303%26dopt%3DAbstract In conclusion, transient AF complicating AMI is associated with an increased future risk of ischaemic stroke and TIA, particularly in patients treated with antiplatelet agents alone. High AF recurrence rates in these patients also suggest that oral anticoagulants should be strongly considered. PMID: 21866303 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5160475 Wed, 24 Aug 2011 23:00:00 +0100 5160475 http://www.medworm.com/index.php?rid=5143306&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21833442%26dopt%3DAbstract In conclusion, infusion of ARC1779 dose-dependently inhibits VWF-dependent platelet function and during infusion ARC1779 increases or stabilises platelet counts in congenital TTP. However, the tested doses, particularly the daily s.c. injections, did not correct all clinical or laboratory features of TTP. PMID: 21833442 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5143306 Wed, 10 Aug 2011 23:00:00 +0100 5143306 http://www.medworm.com/index.php?rid=5143305&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21833443%26dopt%3DAbstract In conclusion, low-dose rFVIIa therapy was successfully used in four patients with severe FXI deficiency undergoing surgery to prevent bleeding and can be monitored using thromboelastometry. PMID: 21833443 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5143305 Wed, 10 Aug 2011 23:00:00 +0100 5143305 http://www.medworm.com/index.php?rid=5143304&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21833444%26dopt%3DAbstract In conclusion, familial investigation for inherited thrombophilia seems justified for probands with previous VTE, but appears of doubtful utility for the relatives of probands without VTE. This should be taken with caution regarding families with deficiency of natural anticoagulants, given the low number of cases analysed. PMID: 21833444 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5143304 Wed, 10 Aug 2011 23:00:00 +0100 5143304 http://www.medworm.com/index.php?rid=5143303&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21833445%26dopt%3DAbstract Authors: Pecci A, Bozzi V, Panza E, Barozzi S, Gruppi C, Seri M, Balduini CL Abstract MYH9 -related disease (MYH9-RD) is an autosomal-dominant thrombocytopenia caused by mutations in the gene for the heavy chain of non-muscle myosin-IIA (NMMHC-IIA). Recent in vitro studies led to the hypothesis that thrombocytopenia of MYH9 -RD derives from an ectopic platelet release by megakaryocytes in the osteoblastic areas of bone marrow (BM), which are enriched in type I collagen, rather than in vascular spaces. SDF-1-driven migration of megakaryocytes within BM to reach the vascular spaces is a key mechanism for platelet biogenesis. Since myosin-IIA is implicated in polarised migration of different cell types, we hypothesised that MYH9 mutations could interfere with this mechanism. We theref... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5143303 Wed, 10 Aug 2011 23:00:00 +0100 5143303 http://www.medworm.com/index.php?rid=5143302&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21833446%26dopt%3DAbstract Authors: Mahan CE, Holdsworth MT, Welch SM, Borrego M, Spyropoulos AC Abstract Preventable venous thromboembolism (VTE) and "appropriate" type, dose, and duration of prophylaxis are emerging concepts. Contemporary definitions by key quality organisations, including the World Health Organization, have shifted towards "preventable" VTE being considered an adverse event or adverse drug event. A decision tree and cost model were developed to estimate the United States health care costs for total deep-vein thrombosis (DVT), total hospital-acquired DVT, and total "preventable" DVT. Annual cost ranges were obtained in 2010 US dollars for total ($7.5 to $39.5 billion), hospital-acquired ($5 to $26.5 billion), and preventable ($2.5 to $19.5 billion) DVT costs. When the sensitivity analysis ... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5143302 Wed, 10 Aug 2011 23:00:00 +0100 5143302 http://www.medworm.com/index.php?rid=5143301&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21833447%26dopt%3DAbstract Authors: Höckner J PMID: 21833447 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5143301 Wed, 10 Aug 2011 23:00:00 +0100 5143301 http://www.medworm.com/index.php?rid=5143300&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21833448%26dopt%3DAbstract In conclusion, despite demonstrated efficacy and established guidelines supporting VTE prophylaxis, utilisation rates and treatment duration remain suboptimal, leaving medical patients at continued risk for VTE. Improved guideline adherence and effective care delivery among the medically ill are stressed. PMID: 21833448 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5143300 Wed, 10 Aug 2011 23:00:00 +0100 5143300 http://www.medworm.com/index.php?rid=5143299&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21833449%26dopt%3DAbstract Authors: Angchaisuksiri P Abstract Venous thromboembolism (VTE) has been perceived for a long time to be less common in Asian populations, particularly in the Far East, than in Western populations. Generally, thromboprophylaxis is not implemented as frequently as it should be in high-risk patients. However, recent prospective studies undertaken in Asian countries have demonstrated higher rates of VTE after major surgery and in medical wards, approaching those observed in Western populations. Risk factors for VTE are not different in Asian patients from those of Western patients with the exception of thrombophilic mutations. Deficiencies of the natural anticoagulants (protein S, protein C, and antithrombin) are the predominant thrombophilias in Asia whereas factor V Leiden and proth... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5143299 Wed, 10 Aug 2011 23:00:00 +0100 5143299 http://www.medworm.com/index.php?rid=5143298&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21833450%26dopt%3DAbstract This article aims to summarise the available evidence documenting the patient and economic burden associated with haemophilia B and current methods of disease management. Both the immediate and long-term clinical consequences of haemophilia B can have significant implications for patients in terms of functional limitations and diminished health-related quality of life (HRQOL). Evidence demonstrates that primary prophylaxis is the optimal strategy for replacing missing clotting factor IX (FIX) and managing haemophilia B. Use of recombinant FIX (rFIX) over plasma-derived FIX (pd-FIX) is also generally preferred for safety reasons. Prophylaxis using currently available rFIX products, however, requires a demanding regimen of intravenous infusions 2-3 times a week which may have significant imp... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5143298 Wed, 10 Aug 2011 23:00:00 +0100 5143298 http://www.medworm.com/index.php?rid=5143297&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21833451%26dopt%3DAbstract Authors: Hermanides RS, Ottervanger JP, Dambrink JH, de Boer MJ, Hoorntje JC, Gosselink AT, Suryapranata H, Zijlstra F, van 't Hof AW, Abstract This is a prospective, observational study performed in all consecutive ST-elevation myocardial infarction (STEMI) patients who had activated clotting time (ACT) measurement on arrival in the cathlab before coronary angiography. We studied the therapeutic effects of a pre-hospital fixed heparin bolus dose in consecutive patients with STEMI. A total of 1,533 patients received pre-hospital administration of aspirin, high dose clopidogrel (600 mg) and a fixed bolus dose of 5,000 IU unfractionated heparin (UFH), according to the national ambulance protocols. Some patients were also treated with glycoprotein IIb/IIIa inhibitors (GPI) in the amb... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5143297 Wed, 10 Aug 2011 23:00:00 +0100 5143297 http://www.medworm.com/index.php?rid=5143296&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21833452%26dopt%3DAbstract Authors: Ragni MV, Jankowitz RC, Jaworski K, Merricks EP, Kloos MT, Nichols TC Abstract Lack of effective treatment for menorrhagia is the greatest unmet healthcare need in women with von Willebrand disease (VWD). We conducted a single-centre phase II clinical trial to determine efficacy and safety of recombinant IL-11 (rhIL-11, Neumega®) given subcutaneously for up to seven days during six consecutive menstrual cycles each in seven women with mild VWD and menorrhagia refractory to haemostatic or hormonal agents. rhIL-11 reduced menstrual bleeding severity as measured by pictorial blood assessment chart (PBAC) ≥50% (to <100) in 71% of subjects, cycle severity ≥50% in 71%, and bleeding duration ≥2 days in 85%, all p≤0.01. After rhIL-11, plasma VWF:RCo increased 1.1-fold,... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5143296 Wed, 10 Aug 2011 23:00:00 +0100 5143296 http://www.medworm.com/index.php?rid=5143295&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21833453%26dopt%3DAbstract Authors: Naldini A, Morena E, Belotti D, Carraro F, Allavena P, Giavazzi R Abstract Blood coagulation cascades can be activated by different mechanisms and to different levels in cancer patients. In a study conducted on the transcriptional profile of epithelial ovarian cancer patients a number of possible links between coagulation and inflammation have been suggested and we and others have reported that, in addition to its central role in blood coagulation and haemostasis, thrombin is a powerful regulator of inflammatory responses. Here, we report that thrombin- like activities were present in the malignant ascites of patients with ovarian carcinoma. Malignant ascites significantly enhanced the release of cytokines/chemokines, which have been previously shown to support tumour prog... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5143295 Wed, 10 Aug 2011 23:00:00 +0100 5143295 http://www.medworm.com/index.php?rid=5143294&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21833454%26dopt%3DAbstract In conclusion, although cardiac troponin testing may not be required in patients with a low sPESI, it adds prognostic value for early death and recurrence for patients with a high sPESI. PMID: 21833454 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5143294 Wed, 10 Aug 2011 23:00:00 +0100 5143294 http://www.medworm.com/index.php?rid=5143293&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21833455%26dopt%3DAbstract Authors: Parrilla R PMID: 21833455 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5143293 Wed, 10 Aug 2011 23:00:00 +0100 5143293 http://www.medworm.com/index.php?rid=5143292&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21833456%26dopt%3DAbstract Authors: Streiff MB PMID: 21833456 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5143292 Wed, 10 Aug 2011 23:00:00 +0100 5143292 http://www.medworm.com/index.php?rid=5143307&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21831097%26dopt%3DAbstract Authors: Hubbard AR, Hamill M, Beeharry M, Bevan SA, Heath AB, Abstract To cite this article: Hubbard AR, Hamill M, Beeharry M, Bevan SA, Heath AB, on behalf of the SSC sub-committee on von Willebrand factor of ISTH. Value assignment of the WHO 2nd International Standard von Willebrand factor, concentrate (09/182). J Thromb Haemost 2011; 9: 1638-40.DOI: 10.1111/j.1538-7836.2011.04365.x. PMID: 21831097 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5143307 Sun, 31 Jul 2011 23:00:00 +0100 5143307 http://www.medworm.com/index.php?rid=5114433&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21792461%26dopt%3DAbstract Authors: Varon D, Huber K PMID: 21792461 [PubMed - in process] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5114433 Sun, 31 Jul 2011 23:00:00 +0100 5114433 http://www.medworm.com/index.php?rid=5114432&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21792462%26dopt%3DAbstract Authors: Fefer P, Matetzky S Clopidogrel reduces ischaemic complications in a wide range of patients with coronary artery disease. However, there is much inter-individual variation in clopidogrel-induced platelet inhibition, and a substantial proportion of patients will exhibit non-responsiveness to clopidogrel. Multiple studies have demonstrated an association between the presence of genetic polymorphisms associated with suboptimal clopidogrel-active metabolite generation, decreased platelet responsiveness, and adverse clinical outcomes. However, it is not clear to what extent the genetic polymorphisms account for the observed variability in response to clopidogrel. In this review we provide a critical summary of the available evidence linking genetic factors with response to clopidog... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5114432 Sun, 31 Jul 2011 23:00:00 +0100 5114432 http://www.medworm.com/index.php?rid=5114431&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21800001%26dopt%3DAbstract In conclusion, FXIII-A Leu34 is a polymorphism which provides a strong resistance to fibrinolysis with a gene-dose effect, but does not relate to premature CAD or to recurrent coronary events in this study. PMID: 21800001 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5114431 Wed, 27 Jul 2011 23:00:00 +0100 5114431 http://www.medworm.com/index.php?rid=5114430&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21800002%26dopt%3DAbstract In conclusion, our results suggest there is a low but quantifiable risk of thromboembolism in VKA-treated patients receiving PCCs for anticoagulation reversal. These findings should be confirmed in randomised, controlled trials. PMID: 21800002 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5114430 Wed, 27 Jul 2011 23:00:00 +0100 5114430 http://www.medworm.com/index.php?rid=5114429&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21800003%26dopt%3DAbstract In conclusion, the pooled c statistic and calibration analysis suggests minimal clinical utility of both the classic and revised view of the CHADS2 in predicting ischaemic stroke across all risk strata. Due to high heterogeneity across studies and low event rates across all risk strata, the results should be interpreted cautiously. Further validation of CHADS2 should perhaps be undertaken, given the methodological differences between many of the available validation studies and the original CHADS2 derivation study. PMID: 21800003 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5114429 Wed, 27 Jul 2011 23:00:00 +0100 5114429 http://www.medworm.com/index.php?rid=5114428&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21800004%26dopt%3DAbstract Authors: Moertl D, Berger R, Hammer A, Hutuleac R, Koppensteiner R, Kopp CW, Steiner S Chronic heart failure (CHF) is characterised by activation of neuroendocrine and inflammatory pathways, and both are linked to a prothrombotic state. Treatment with omega-3 polyunsaturated fatty acids (n3-PUFA) showed significant benefits including mortality reduction in CHF, but exact mechanisms of action are still unclear. We investigated the effects of n3-PUFA on markers of platelet activation and thrombogenesis in patients with severe CHF. Thirty-six patients with non-ischaemic CHF (LVEF<35%, NYHA class>2) under optimised therapy were randomised to supplementation with 1g/day or 4g/day n3-PUFA, or placebo for 12 weeks. Using whole-blood flow cytometry, monocyte-platelet aggregates character... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5114428 Wed, 27 Jul 2011 23:00:00 +0100 5114428 http://www.medworm.com/index.php?rid=5114427&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21800005%26dopt%3DAbstract Authors: Lima LG, Oliveira AS, Campos LC, Bonamino M, Chammas R, Werneck C, Vicente CP, Barcinski MA, Petersen LC, Monteiro RQ Shedding of microvesicles (MVs) by cancer cells is implicated in a variety of biological effects, including the establishment of cancer-associated hypercoagulable states. However, the mechanisms underlying malignant transformation and the acquisition of procoagulant properties by tumour-derived MVs are poorly understood. Here we investigated the procoagulant and prothrombotic properties of MVs produced by a melanocyte-derived cell line (melan-a) as compared to its tumourigenic melanoma counterpart Tm1. Tumour cells exhibit a two-fold higher rate of MVs production as compared to melan-a. Melanoma MVs display greater procoagulant activity and elevated levels of t... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5114427 Wed, 27 Jul 2011 23:00:00 +0100 5114427 http://www.medworm.com/index.php?rid=5114426&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21800006%26dopt%3DAbstract In conclusion, baseline plasma vitronectin is a marker of incident MetS at nine years. Its predictive ability for MetS and T2DM should not be assessed independently of PAI-1 levels. PMID: 21800006 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5114426 Wed, 27 Jul 2011 23:00:00 +0100 5114426 http://www.medworm.com/index.php?rid=5114425&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21800007%26dopt%3DAbstract In conclusion, fibrinogen is weakly associated with CVD risk (predicted overall risk as well with individual risk factors) in black South Africans, and is related to the degree of urbanisation. Increased fibrinogen concentration, in black South Africans, especially in rural areas, is largely unexplained, and likely not strongly correlated with traditional CVD-related lifestyle and pathophysiological processes. This does, however, not exclude the possibility that once increased, the fibrinogen concentration contributes to future development of CVD. PMID: 21800007 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5114425 Wed, 27 Jul 2011 23:00:00 +0100 5114425 http://www.medworm.com/index.php?rid=5114424&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21800008%26dopt%3DAbstract In conclusion, the bacterial proteins SclA and SclB bind to a TAFI fragment encompassing residues G205-D232. Binding of TAFI to the bacteria may allow activation of TAFI, whereafter the enzyme easily dissociates. PMID: 21800008 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5114424 Wed, 27 Jul 2011 23:00:00 +0100 5114424