MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Thrombosis and Haemostasis' source. Fri, 19 Mar 2010 15:32:35 +0100 http://www.medworm.com/index.php?rid=3359274&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20216980%26dopt%3DAbstract Authors: Lutgens E, Poggi M, Weber C PMID: 20216980 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3359274 Wed, 10 Mar 2010 00:00:00 +0100 3359274 http://www.medworm.com/index.php?rid=3359275&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20216979%26dopt%3DAbstract Authors: Lankeit M, Konstantinides S Patients with high-risk pulmonary embolism (PE), i.e. those with shock or hypotension at presentation, are at high risk of in-hospital death, particularly during the first hours after admission. A meta-analysis of trials which included haemodynamically compromised patients indicated that thrombolytic treatment significantly reduces the rate of in-hospital death or PE recurrence. Therefore, thrombolysis should be administered to patients with high-risk PE unless there are absolute contraindications to its use. Uncontrolled data further suggest that thrombolysis may be a safe and effective alternative to surgery in patients with PE and free-floating thrombi in the right heart. On the other hand, normotensive patients generally have a favourable short-... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3359275 Tue, 09 Mar 2010 00:00:00 +0100 3359275 http://www.medworm.com/index.php?rid=3359273&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20216981%26dopt%3DAbstract Authors: Cremer M, Weimann A, Schmalisch G, Hammer H, Bührer C, Dame C Newly released platelets, referred to as immature platelets, can be reliably quantified based on their RNA content by flow cytometry in an automated blood analyser. The absolute number of immature platelets (IPF#) and the immature platelet fraction (IPF%) reflect megakaryopoietic activity. We aimed to analyse the implication of these parameters in analysing the pathomechanism of early-onset neonatal thrombocytopenia. Platelet counts and IPF were determined at day 1 to 3 (d1 to d3) in 857 neonates admitted to intensive care. In thrombocytopenic patients (platelet counts<150 x 10(9)/l, n=129), IPF# was significantly lower (8.5 +/- 2.7 x 10(9)/l), than in non-thrombocytopenic neonates (9.5 +/- 3.6 x 10(9)/l, n=... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3359273 Tue, 09 Mar 2010 00:00:00 +0100 3359273 http://www.medworm.com/index.php?rid=3359272&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20216982%26dopt%3DAbstract Authors: He S, Blombäck M, Bark N, Johnsson H, Wallén NH The present study aimed to assess whether the fibrin network structure is modified by the direct thrombin-inhibitors lepirudin, argatroban or bivalirudin and by the indirect Xa-inhibitor danaparoid. Using an in vitro assay that imitates the physiological process of coagulation from thrombin generation to fibrin formation, we examined a normal plasma pool spiked with one of the inhibitors. At concentrations considered to be the plasma levels observed during therapy, almost no influence was detected for lepirudin despite clear-cut effects on "clotting time". However, argatroban, bivalirudin and danaparoid increased the fibrin gel permeability (Ks) to a similar extent. At concentrations higher than the "therapeutic" levels... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3359272 Tue, 09 Mar 2010 00:00:00 +0100 3359272 http://www.medworm.com/index.php?rid=3359271&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20216983%26dopt%3DAbstract Authors: Schroecksnadel K, Grammer TB, Boehm BO, März W, Fuchs D Moderate hyperhomocysteinaemia is considered as an independent risk marker for cardiovascular disease and stroke. Earlier, increased homocysteine production was detected in stimulated immunocompetent cells in vitro, and several markers of inflammation like neopterin or C-reactive protein (CRP) were demonstrated as significant indicators of cardiovascular risk. The relationship between coronary artery disease (CAD), homocysteine metabolism and markers of immune activation and inflammation was investigated in a population of 1717 patients undergoing coronary angiography, recruited as participants of the LUdwigshafen RIsk and Cardiovascular Health (LURIC) study. 1325 patients (77.2%) suffered from coronary artery diseas... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3359271 Tue, 09 Mar 2010 00:00:00 +0100 3359271 http://www.medworm.com/index.php?rid=3359270&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20216984%26dopt%3DAbstract Authors: Van Walderveen MC, Berry LR, Atkinson HM, Chan AK Thrombomodulin (TM), which variably contains a chondroitin sulfate (+/-CS), forms an anticoagulant complex with thrombin (IIa). IIa-TM(+/-CS) converts protein C (PC) into activated PC (APC), which then inactivates activated factors V (FVa) and VIII (FVIIIa). This reduces prothrombinase and tenase complexes that generate IIa. Heparin (H) increases the rate of IIa-TM inhibition by antithrombin (AT) and enhances FV cleavage by APC. Our novel covalent AT-H (ATH) product, has superior anticoagulant activity compared to AT + unfractionated H (UFH). We studied mechanisms by which ATH versus AT + UFH inhibits IIa-TM(+/-CS), and ATH influences on APC cleavage of FV/FVa compared to UFH. Findings would determine how these reactions modera... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3359270 Tue, 09 Mar 2010 00:00:00 +0100 3359270 http://www.medworm.com/index.php?rid=3359269&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20216985%26dopt%3DAbstract Authors: Burggraf D, Vosko MR, Schubert M, Stassen JM, Hamann GF Recombinant tissue plasminogen activator (rt-PA) is successfully used in human stroke, but often shows serious drawbacks. To find an alternative, we hypothesised that the novel thrombolytic microplasmin would have fewer adverse effects on haemoglobin extravasation and microvascular damage compared with the effects of rt-PA and tenecteplase (TNK). A constant period of ischaemia (3 hours) was induced in a rat suture model followed by reperfusion (24 hours). Mikroplasmin (10 mg/kg), TNK (5 mg/kg), rt-PA (9 mg/kg) and saline (control), were administered. The volume of the ischaemic lesion was calculated, the loss of collagen type IV and the extravasation of haemoglobin were quantified by Western blotting. The matrix-metallopr... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3359269 Tue, 09 Mar 2010 00:00:00 +0100 3359269 http://www.medworm.com/index.php?rid=3359268&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20216986%26dopt%3DAbstract Authors: Samoylenko A, Dimova EY, Kozlova N, Drobot L, Kietzmann T Increased levels of plasminogen activator inhibitor-1 (PAI-1) indicate an enhanced risk of ischaemic/hypoxic cardiovascular events and a poor prognosis. The expression of PAI-1 can be induced by various stimuli including hypoxia, insulin and insulin-like growth factor 1 (IGF-1). The hypoxia-inducible factor-1 (HIF-1) is critical for hypoxia or insulin/IGF-1 mediated PAI-1 induction, but the components involved in merging the signals are not known so far. The adaptor/scaffold protein Ruk/CIN85 may be a candidate since it plays important roles in the regulation of processes associated with cardiovascular and oncological diseases such as downregulation of receptor tyrosine kinases, apoptosis, adhesion and invasion. Therefo... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3359268 Tue, 09 Mar 2010 00:00:00 +0100 3359268 http://www.medworm.com/index.php?rid=3359267&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20216987%26dopt%3DAbstract Authors: Mazzaglia G, Filippi A, Alacqua M, Cowell W, Shakespeare A, Mantovani LG, Bianchi C, Cricelli C The aims of this study were to investigate trends in the incidence of diagnosed atrial fibrillation (AF), and to identify factors associated with the prescription of antithrombotics (ATs) and to identify the persistence of patients with oral anticoagulant (OAC) treatment in primary care. Data were obtained from 400 Italian primary care physicians providing information to the Health Search/Thales Database from 2001 to 2004. The age-standardised incidence of AF was: 3.9-3.0 cases, and 3.6-3.0 cases per 1,000 person-years in males and females, respectively. During the study period, 2,016 (37.2%) patients had no prescription, 1,663 (30.7%) were prescribed an antiplatelet (AP) agent, 1,4... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3359267 Tue, 09 Mar 2010 00:00:00 +0100 3359267 http://www.medworm.com/index.php?rid=3359266&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20216988%26dopt%3DAbstract Authors: Zbidi H, Redondo PC, Lopez J, Bartegi A, Salido G, Rosado JA Diabetes mellitus is a disease characterised by hyperglycaemia and associated with several cardiovascular disorders, including angiopathy and platelet hyperactivity, which are major causes of morbidity and mortality in type 2 diabetes mellitus. In type 2 diabetic patients, homocysteine levels are significantly increased compared with healthy subjects. Hyperhomocysteinaemia is an independent risk factor for macro- and microangiopathy and mortality. The present study is aimed to investigate the effect of homocysteine on platelet apoptosis. Changes in cytosolic or intraluminal free Ca2+ concentration were determined by fluorimetry. Caspase activity and phosphorylation of the eukaryotic initiation factor 2alpha (eIF2alph... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3359266 Tue, 09 Mar 2010 00:00:00 +0100 3359266 http://www.medworm.com/index.php?rid=3359265&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20216989%26dopt%3DAbstract Authors: Kozian DH, Lorenz M, März W, Cousin E, Mace S, Deleuze JF The thrombin-activatable fibrinolysis inhibitor (TAFI) is a key mediator in the regulation of endogenous fibrinolysis, down-regulating clot lysis by degrading the C-terminal lysine residues from fibrin, which are important for binding and activating plasminogen. Elevated TAFI antigen levels have been suggested to be associated with promoter variants and the Ala147Thr polymorphism; increased TAFI stability and antifibrinolytic potential instead have been associated with the Thr325Ile polymorphism. We investigated the influence of these two polymorphisms on cardiovascular and thrombotic events in patients of the Ludwigshafen Risk and Cardiovascular Health (LURIC) study. The LURIC study is a prospective cohort study c... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3359265 Tue, 09 Mar 2010 00:00:00 +0100 3359265 http://www.medworm.com/index.php?rid=3359264&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20216990%26dopt%3DAbstract Authors: Jespersen J, Poller L, van den Besselaar AM, van der Meer FJ, Palareti G, Tripodi A, Shiach C, Keown M, Ibrahim S Anticoagulant control facilities are being overwhelmed by requests for monitoring and large numbers of patients are not therefore receiving treatment. Procedures designed for point-of-care testing have therefore been developed, the most popular being the CoaguChek. The need for external quality assessment (EQA) of monitors used by patients in self-management has been stressed in a European Commission (EC) Directive. It would not however be feasible for all CoaguChek monitors to be enrolled in national or regional EQA schemes which take time to organise and analyse. The European Concerted Action on Anticoagulation (ECAA) has therefore evolved a simpler system. Its v... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3359264 Tue, 09 Mar 2010 00:00:00 +0100 3359264 http://www.medworm.com/index.php?rid=3359263&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20216991%26dopt%3DAbstract We report on a novel integrin-dependent platelet dysfunction in two brothers with LAD-III syndrome caused by a homozygous mutation 1717C>T in the FERMT3 gene leading to a premature stop codon R573X in the focal adhesion protein kindlin-3. Stimulation of patients platelets with all used agonists resulted in a severely decreased binding of soluble fibrinogen indicating a defect in inside-out activation of the integrin aIIbb3 (GPIIb/IIIa). Patients platelets did not respond to the a2b1-integrin agonist aggretin-A at all. Our data on granula secretion indicate for the first time that the thrombin receptor PAR-4 but not PAR-1 may be important in integrin-triggered granule secretion in response to thrombin. In contrast, collagen mediated platelet granule secretion was not affected in LAD-III-... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3359263 Tue, 09 Mar 2010 00:00:00 +0100 3359263 http://www.medworm.com/index.php?rid=3359262&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20216992%26dopt%3DAbstract Authors: van der Wal DE, Verhoef S, Schutgens RE, Peters M, Wu Y, Akkerman JW Incubation at 0 degrees C is known to expose beta-N-acetyl-D-glucosamine residues on glycoprotein (GP) Ibetaalpha inducing receptor clustering and alphaMb2-mediated platelet destruction by macrophages. Here we show that incubation at 0/37 degrees C (4 hours at 0 degrees C, followed by 1 hour at 37 degrees C to mimic cold-storage and post-transfusion conditions) triggers a conformational change in the N-terminal flank (NTF, amino acids, aa 1-35) but not in aa 36-282 of GPIbalpha as detected by antibody binding. Addition of the sugar N-acetyl-D-glucosamine (GN) inhibits responses induced by 0/37 degrees C. Incubation at 0 degrees C shifts GPIbalpha from the membrane skeleton to the cytoskeleton. Different GPIba... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3359262 Tue, 09 Mar 2010 00:00:00 +0100 3359262 http://www.medworm.com/index.php?rid=3359261&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20216993%26dopt%3DAbstract Authors: Aquino RS, Pereira MS, Vairo BC, Cinelli LP, Santos GR, Fonseca RJ, Mourao PA Increasing reports of bleeding and peri- or post-operative blood dyscrasias in Brazil were possibly associated with the use of heparin from bovine instead of porcine intestine. These two pharmaceutical grade heparins were analysed for potential differences. NMR analyses confirmed that porcine heparin is composed of mainly trisulfated disaccharides -->4-alpha-IdoA2S-1-->4-alpha-GlcNS6S-1-->. Heparin from bovine intestine is also composed of highly 2-sulfated alpha-iduronic acid residues, but the sulfation of the alpha-glucosamine units vary significantly: ~50% are 6- and N -disulfated, as in porcine heparin, while ~36% are 6-desulfated and ~14% N -acetylated. These heparins differ significant... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3359261 Tue, 09 Mar 2010 00:00:00 +0100 3359261 http://www.medworm.com/index.php?rid=3298890&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20174749%26dopt%3DAbstract Authors: Jaipersad AS, Silverman SH, Lip GY PMID: 20174749 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3298890 Fri, 19 Feb 2010 00:00:00 +0100 3298890 http://www.medworm.com/index.php?rid=3298889&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20174750%26dopt%3DAbstract Authors: Schwerte T PMID: 20174750 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3298889 Fri, 19 Feb 2010 00:00:00 +0100 3298889 http://www.medworm.com/index.php?rid=3298888&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20174751%26dopt%3DAbstract Authors: Haas S PMID: 20174751 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3298888 Fri, 19 Feb 2010 00:00:00 +0100 3298888 http://www.medworm.com/index.php?rid=3298887&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20174752%26dopt%3DAbstract Authors: Gibson NS, Douma RA, Squizzato A, Söhne M, Büller HR, Gerdes VE Current strategies for diagnosing pulmonary embolism (PE) include a clinical decision rule (CDR), followed by a D-dimer assay in patients with an unlikely clinical probability. We assessed the implementation of the current guidelines for the diagnosis of PE. A first questionnaire was sent to internists and pulmonologists to assess the proportion of physicians that adequately applied the guidelines. Two versions of a second questionnaire were sent presenting five hypothetical cases of which in two cases with an intermediate clinical probability an abnormal D-dimer test result was added to one version. We assessed the variation of the CDR and compared the proportions of a likely clinical probability betwee... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3298887 Fri, 19 Feb 2010 00:00:00 +0100 3298887 http://www.medworm.com/index.php?rid=3298886&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20174753%26dopt%3DAbstract Authors: Lu Y, Xie B, Ding Q, Dai J, Xi X, Wang M, Wang H, Wang X PMID: 20174753 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3298886 Fri, 19 Feb 2010 00:00:00 +0100 3298886 http://www.medworm.com/index.php?rid=3298885&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20174754%26dopt%3DAbstract This study investigates the effects of leptin, in a concentration range usually observed in the plasma of patients with increased cardiovascular risk or measurable in patients with acute coronary syndromes, on tissue factor (TF) and cellular adhesion molecules (CAMs) expression in human coronary endothelial cells (HCAECs). We demonstrate that leptin induces transcription of mRNA for TF and CAMs by real-time PCR. In addition, we show that this adipokine promotes surface expression of TF and CAMs that are functionally active since we observed increased procoagulant activity and leukocyte adhesion on cell surface. Leptin effects appear modulated by eNOS-production of oxygen free radicals through the activation of the transcription factor, nuclear factor(NF)-kB, since L-NAME, Superoxide Dismut... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3298885 Fri, 19 Feb 2010 00:00:00 +0100 3298885 http://www.medworm.com/index.php?rid=3298884&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20174755%26dopt%3DAbstract Authors: McLeish JA, Chico TJ, Taylor HB, Tucker C, Donaldson K, Brown SB Low mass ambient exposure to airborne particles is associated with atherothrombotic events that may be a consequence of the combustion-derived nanoparticle content. There is concern also over the potential cardiovascular impact of manufactured nanoparticles. To better understand the mechanism by which toxic airborne particles can affect cardiovascular function we utilised zebrafish as a genetically tractable model. Using light and confocal fluorescence video-microscopy, we measured heart-rate and blood flow in the dorsal aorta and caudal artery of zebrafish larvae that had been exposed to a number of toxic and non-toxic microparticles and nanoparticles. Diesel exhaust particles (DEP), carboxy-charged LatexTM bead... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3298884 Fri, 19 Feb 2010 00:00:00 +0100 3298884 http://www.medworm.com/index.php?rid=3298883&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20174756%26dopt%3DAbstract Authors: Raaz U, Kaeberich A, Maegdefessel L, Buerke M, Busshardt M, Schubert S, Russ M, Plehn A, Ebelt H, Werdan K, Schlitt A The direct thrombin inhibitor argatroban offers some significant advantages over unfractionated heparin (UFH) and is recommended as an alternative anticoagulant during percutaneous coronary interventions (PCI). The impact of argatroban on cardiac catheter thrombosis - a severe potential complication of PCI - has not been systematically studied yet. The aim of the present study was to test in vitro the hypothesis that argatroban is equivalent to the more established anticoagulants UFH and enoxaparin in preventing catheter thrombus formation. Blood pretreated with the anticoagulants of interest was continuously circulated through a guiding catheter by using a rol... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3298883 Fri, 19 Feb 2010 00:00:00 +0100 3298883 http://www.medworm.com/index.php?rid=3298882&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20174757%26dopt%3DAbstract This study investigated the role of CD40L in pro-inflammatory gene expression and cellular differentiation in adipose tissue to obtain insight into mechanisms linking the MS with atherosclerosis. Human adipocytes and preadipocytes expressed CD40 but not CD40L. Stimulation with recombinant CD40L or membranes over-expressing CD40L induced a time- and dose-dependent expression of IL-6, MCP-1, IL-8, and PAI-1. Supernatants of CD40L-stimulated adipose cells activated endothelial cells, suggesting a systemic functional relevance of our findings. Neutralising antibodies against CD40L attenuated these effects substantially. Signalling studies revealed the involvement of mitogen-activated protein kinases and NFkB. Furthermore, stimulation with CD40L resulted in enhanced activation of C/EBPa and PPA... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3298882 Fri, 19 Feb 2010 00:00:00 +0100 3298882 http://www.medworm.com/index.php?rid=3298881&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20174758%26dopt%3DAbstract Authors: Said JM, Ignjatovic V, Monagle PT, Walker SP, Higgins JR, Brennecke SP Protein S, protein C and antithrombin are important regulators of coagulation. While deficiencies of these proteins have been linked to adverse pregnancy outcomes, testing for these deficiencies during pregnancy is limited by the use of non-pregnant reference ranges and a limited understanding of the changes that occur during pregnancy. Although several small studies have previously reported on the activity of these proteins during pregnancy, potentially important changes have been overlooked by continuing to compare the activity during pregnancy with non-pregnant reference ranges. In the current study, we investigated the activity of protein S, protein C and antithrombin during the first half of pregnancy ... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3298881 Fri, 19 Feb 2010 00:00:00 +0100 3298881 http://www.medworm.com/index.php?rid=3298880&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20174759%26dopt%3DAbstract Authors: Sermon AM, Smith JM, Maclean R, Kitchen S The International Normalised Ratio (INR)/International Sensitivity Index (ISI) system was developed as a way to standardise the prothrombin time during the monitoring of patients undergoing oral anti-coagulant therapy with vitamin K antagonists. The wide acceptance of the INR has led to its use as one of three parameters used in the Model for End stage Liver disease (MELD) scoring system to aid the prioritisation of patients for liver transplant. Literature published recently has highlighted the potential inadequacy of the INR system in this context. Our aim was to investigate the degree of difference between INR values calculated using an ISI derived from warfarinised patients and those calculated using an ISI derived from patients wi... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3298880 Fri, 19 Feb 2010 00:00:00 +0100 3298880 http://www.medworm.com/index.php?rid=3298879&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20174760%26dopt%3DAbstract Authors: Savoia A, De Rocco D, Panza E, Bozzi V, Scandellari R, Loffredo G, Mumford A, Heller PG, Noris P, De Groot MR, Giani M, Freddi P, Scognamiglio F, Riondino S, Pujol-Moix N, Fabris F, Seri M, Balduini CL, Pecci A MYH9 -related disease (MYH9 -RD) is an autosomal dominant thrombocytopenia with giant platelets variably associated with young-adult onset of progressive sensorineural hearing loss, presenile cataract, and renal damage. MYH9 -RD is caused by mutations of MYH9 , the gene encoding for non-muscle heavy-chain myosin-9. Wild-type and mutant myosin-9 aggregate as cytoplasmic inclusions in patients' leukocytes, the identification of which by immunofluorescence has been proposed as a suitable tool for the diagnosis of MYH9 -RD. Since the predictive value of this assay, in terms... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3298879 Fri, 19 Feb 2010 00:00:00 +0100 3298879 http://www.medworm.com/index.php?rid=3298878&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20174761%26dopt%3DAbstract In conclusion, circulating BPI could constitute a biomarker of lipid metabolism in subjects with normal glucose tolerance and could help to identify those subjects with preserved endothelial function. PMID: 20174761 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3298878 Fri, 19 Feb 2010 00:00:00 +0100 3298878 http://www.medworm.com/index.php?rid=3298877&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20174762%26dopt%3DAbstract This study determined the age-related response following administration of a single UFH bolus of 75-100 IU/kg in children. Venous blood samples were collected from children (n=55) at 15, 30, 45 and 120 minutes post-UFH. Anti-Xa, anti-IIa, APTT, TCT and protamine titration were performed on all samples. Age-dependent differences in the effect and concentration of UFH were identified for the anti-Xa, anti-IIa and protamine titration assays, respectively. In addition, a trend suggesting a proportional increase in anti-Xa and anti-IIa-mediated UFH effect with age was evident. Logistic regression demonstrated an increase in protamine titration of 0.6 IU/ml for every year of age in samples collected 15 minutes post-UFH. UFH-mediated anti-IIa activity was reduced compared to anti-Xa activity acro... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3298877 Fri, 19 Feb 2010 00:00:00 +0100 3298877 http://www.medworm.com/index.php?rid=3298876&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20174763%26dopt%3DAbstract Authors: Basili S, Raparelli V, Vestri A, Di Tanna GL, Violi F It was the aim of the present study to investigate if antiplatelet treatment reduced cardiovascular events in patients with claudication and/or an ankle/brachial index (ABI) pound0.99 and to analyse if specific antiplatelet treatment had a different impact on clinical outcome. We performed a meta-analysis of 29 clinical randomized trials on antiplatelet therapy for prevention of vascular death, myocardial infarction, and stroke in 10,735 peripheral artery disease patients. The primary end-point utilizing in the meta-analysis construction was Cardiovascular Adverse Event. We found 1,900 (17.70%) patients in trials with aspirin, 5,326 (49.61%) in those with thienopyridines, 2,324 (21.65%) in those with picotamide and 1,185 (1... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3298876 Fri, 19 Feb 2010 00:00:00 +0100 3298876 http://www.medworm.com/index.php?rid=3298875&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20174764%26dopt%3DAbstract Conclusion: 1) In this small subset of patients diagnostic magnetic resonance imaging to monitor early asymptomatic or subclinical vascular damage in the brain can be considered when they reach the age of 20 years, and repeated every 3-5 years. 2) Treatment with antiplatelet aggregants is suggested in patients with documented asymptomatic brain ischaemia. 3) These results require confirmation in a larger group of similar patients with other types of thalassaemia who are multitransfused or have an intact spleen. PMID: 20174764 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3298875 Fri, 19 Feb 2010 00:00:00 +0100 3298875 http://www.medworm.com/index.php?rid=3298874&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20174765%26dopt%3DAbstract Authors: Ignjatovic V, Summerhayes R, Newall F, Monagle PT PMID: 20174765 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3298874 Fri, 19 Feb 2010 00:00:00 +0100 3298874 http://www.medworm.com/index.php?rid=3298873&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20174766%26dopt%3DAbstract Authors: Lawall H, Bramlage P, Amann B Atherosclerotic peripheral artery disease (PAD) is a common manifestation of atherosclerosis. The occlusion of large limb arteries leads to ischaemia with claudication which can progress to critical limb ischaemia (CLI) with pain at rest, and to tissue loss. At present, common therapy for CLI is either surgical or endovascular revascularisation aimed at improving blood flow to the affected extremity. However, major amputation and death are still frequent complications. Exploring new strategies for revascularisation of ischaemic limbs is thus of major importance. Bone marrow (BM)-derived stem and progenitor cells have been identified as a potential new therapeutic option to induce therapeutic angiogenesis. Encouraging results of preclinical studies... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3298873 Fri, 19 Feb 2010 00:00:00 +0100 3298873 http://www.medworm.com/index.php?rid=3298872&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20174767%26dopt%3DAbstract Authors: Grandone E, Tiscia G, Colaizzo D, Vergura P, Pisanelli D, Margaglione M PMID: 20174767 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3298872 Fri, 19 Feb 2010 00:00:00 +0100 3298872 http://www.medworm.com/index.php?rid=3298871&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20174768%26dopt%3DAbstract In this study, we establish gestational age-specific reference intervals for coagulation tests during normal pregnancy. Eight hundred one women with expected normal pregnancies were included in the study. Of these women, 391 had no complications during pregnancy, vaginal delivery, or postpartum period. Plasma samples were obtained at gestational weeks 13-20, 21-28, 29-34, 35-42, at active labor, and on postpartum days 1 and 2. Reference intervals for each gestational period using only the uncomplicated pregnancies were calculated in all 391 women for activated partial thromboplastin time (aPTT), fibrinogen, fibrin D-dimer, antithrombin, free protein S, and protein C and in a subgroup of 186 women in addition for prothrombin time (PT), Owren and Quick PT, protein S activity, and total prote... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3298871 Fri, 19 Feb 2010 00:00:00 +0100 3298871 http://www.medworm.com/index.php?rid=3298870&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20174769%26dopt%3DAbstract In conclusion, women were more frequently referred for a diagnostic work-up for DVT than men, but the prevalence of DVT was higher in men and their thrombotic events were more severe. Nevertheless, the Wells clinical pretest probability score correctly identified low- and high-risk groups in both genders. PMID: 20174769 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3298870 Fri, 19 Feb 2010 00:00:00 +0100 3298870 http://www.medworm.com/index.php?rid=3298869&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20174770%26dopt%3DAbstract Authors: Novy J, Ballhausen D, Bonafé L, Cairoli A, Angelillo-Scherrer A, Bachmann C, Michel P PMID: 20174770 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3298869 Fri, 19 Feb 2010 00:00:00 +0100 3298869 http://www.medworm.com/index.php?rid=3259391&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20143010%26dopt%3DAbstract Authors: Schrör K, Bretschneider E, Fischer K, Fischer JW, Pape R, Rauch BH, Rosenkranz AC, Weber AA The vast majority of thrombin (>95%) is generated after clotting is completed, suggesting that thrombin formation serves purposes beyond coagulation, such as tissue repair after vessel injury. Two types of vascular thrombin binding sites exist: protease-activated receptors (PARs) and thrombomodulin (TM). Their expression is low in contractile vascular smooth muscle cells (SMC), the dominating subendothelial cell population, but becomes markedly up-regulated upon injury. In human SMC, PAR-1, PAR-3, and PAR-4 mediate thrombin-induced proliferation, migration and matrix biosynthesis as well as generation of inflammatory and growth-promoting mediators. Thrombin-responsive PARs are t... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3259391 Mon, 08 Feb 2010 00:00:00 +0100 3259391 http://www.medworm.com/index.php?rid=3247451&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20135055%26dopt%3DAbstract Authors: De Caterina R, Zimarino M PMID: 20135055 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3247451 Tue, 02 Feb 2010 00:00:00 +0100 3247451 http://www.medworm.com/index.php?rid=3247450&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20135056%26dopt%3DAbstract Authors: Lip GY PMID: 20135056 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3247450 Tue, 02 Feb 2010 00:00:00 +0100 3247450 http://www.medworm.com/index.php?rid=3247449&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20135057%26dopt%3DAbstract Authors: Peter K, Lip GY PMID: 20135057 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3247449 Tue, 02 Feb 2010 00:00:00 +0100 3247449 http://www.medworm.com/index.php?rid=3247448&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20135058%26dopt%3DAbstract Authors: Vismara E, Pierini M, Mascellani G, Liverani L, Lima M, Guerrini M, Torri G Hydrogen peroxide (H2O2) and Cu(OAc)2 or FeSO4 (Fenton type reagents) perform heparin (Hep) depolymerisation to low-molecular-weight heparin (LMWH) following a radical chain mechanism. Hydroxyl (OH) radicals which are initially generated from H2O2 reduction by transition metal ions abstract hydrogen atoms on the heparin chain providing carbon centred radicals whose decay leads to the depolymerisation process. The main depolymerisation mechanism involves Hep radical intermediates that cleave the glycosidic linkage at unsulphated uronic acids followed by a 6-O-nonsulphated glucosamine, thus largely preserving the pentasaccharide sequence responsible for the binding to antithrombin III (AT). Both the tran... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3247448 Tue, 02 Feb 2010 00:00:00 +0100 3247448 http://www.medworm.com/index.php?rid=3247447&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20135059%26dopt%3DAbstract This study aimed to find assays, among those commercially available, to measure rivaroxaban pharmacodynamics. Several global conventional clotting tests, as well as clotting or chromogenic assays to measure anti-factor Xa activity, were studied. A thrombin generation test using calibrated automated thrombogram was also done. Tests were performed with the indirect factor Xa inhibitor fondaparinux for comparison. A concentration-dependent prolongation of PT, dilute PT, and aPTT was observed with rivaroxaban. The results varied depending on the reagents. This variability cannot be standardised with the international normalised ratio system commonly used for vitamin K antagonists. Using a standard calibration curve, PT test results can be expressed in plasma concentrations of rivaroxaban rathe... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3247447 Tue, 02 Feb 2010 00:00:00 +0100 3247447 http://www.medworm.com/index.php?rid=3247446&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20135060%26dopt%3DAbstract Authors: Sand C, Grandoch M, Börgermann C, Oude Weernink PA, Mahlke Y, Schwindenhammer B, Weber AA, Fischer J, Jakobs KH, Schmidt M Membrane-permeable 8-(4-chlorophenylthio)-2'-O-methyl cyclic AMP (8-pCPT-2'-O-Me-cAMP) has been shown to specifically activate cAMP-regulated Epac proteins, without direct effects on protein kinase A and protein kinase G. During isometric tension measurements in thoracic aortic rings from Wistar rats, we observed that 8-pCPT-2'-O-Me-cAMP selectively induced a rightward shift of the concentration response curve for the thromboxane mimetic U46619, without altering the contractile response to noradrenaline. We hypothesised that 8-pCPT-2'-O-Me-cAMP and similar compounds may function as direct thromboxane receptor antagonists. Indeed, in addition to 8-pCPT... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3247446 Tue, 02 Feb 2010 00:00:00 +0100 3247446 http://www.medworm.com/index.php?rid=3247445&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20135061%26dopt%3DAbstract Authors: Cuisset T, Hamilos M, Delrue L, Frère C, Verhamme K, Bartunek J, Saut N, Bonnet JL, Eijgelsheim M, Wijns W, Alessi MC, Barbato E Platelet response to clopidogrel shows inter-individual variability that is partially explained by genetic polymorphisms. This variability affects clinical outcome when clopidogrel is administered in patients with acute coronary syndrome (ACS). Catecholamines, released during ACS, contribute to platelet aggregation through platelet alpha2A- (alpha2A-AR) and beta2-adrenergic receptor (beta2-AR) stimulation. It was the objective of this study to assess the potential influence of alpha2A-AR and beta2-AR gene polymorphisms on platelet reactivity after dual antiplatelet therapy with aspirin and clopidogrel in ACS. We screened 641 ACS patients for 6.3... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3247445 Tue, 02 Feb 2010 00:00:00 +0100 3247445 http://www.medworm.com/index.php?rid=3247444&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20135062%26dopt%3DAbstract Authors: Zawilska K, Undas A, Fish RJ, Molendowicz-Portala L, De Moerloose P, Neerman-Arbez M PMID: 20135062 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3247444 Tue, 02 Feb 2010 00:00:00 +0100 3247444 http://www.medworm.com/index.php?rid=3247443&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20135063%26dopt%3DAbstract Authors: Sofi F, Marcucci R, Gori AM, Giusti B, Abbate R, Gensini GF We performed this meta-analysis to update the clinical evidences on the relation between clopidogrel non-responsiveness and clinical outcomes in patients with coronary artery disease (CAD) who underwent percutaneous coronary intervention. An electronic literature search through MEDLINE, EMBASE, Web of Science, and the Cochrane Library and bibliographies of retrieved articles up to January, 2009 was conducted. Studies were included if they had a cohort prospective design, if they analysed clopidogrel responsiveness in CAD patients in relation to death and/or occurrence of adverse coronary events during follow-up, and if they reported an adequate statistical analysis. Fourteen studies, totalling 4,564 CAD patients follo... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3247443 Tue, 02 Feb 2010 00:00:00 +0100 3247443 http://www.medworm.com/index.php?rid=3247442&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20135064%26dopt%3DAbstract We report preliminary results obtained with Raloxifene to treat epistaxis in postmenopausal HHT women diagnosed with osteoporosis. We tried to unravel the molecular mechanisms involved in the therapeutic effects of raloxifene. ENG and ACVRL1 genes code for proteins involved in the transforming growth factor b pathway and it is widely accepted that haploinsufficiency is the origin for the pathogenicity of HHT. Therefore, identification of drugs able to increase the expression of those genes is essential to propose new therapies for HHT. In vitro results show that raloxifene increases the protein and mRNA expression of ENG and ALK1 in cultured endothelial cells. Raloxifene also stimulates the promoter activity of these genes, suggesting a transcriptional regulation of ENG and ALK1 . Furtherm... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3247442 Tue, 02 Feb 2010 00:00:00 +0100 3247442 http://www.medworm.com/index.php?rid=3247441&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20135065%26dopt%3DAbstract Authors: Munuswamy-Ramanujam G, Dai E, Liu L, Shnabel M, Sun YM, Bartee M, Lomas DA, Lucas AR Thrombolytic serine proteases not only initiate fibrinolysis, but also are up-regulated in vascular disease and acute inflammatory responses. Although the serine protease inhibitor (serpin) plasminogen activator inhibitor-1 (PAI-1) is considered a main regulator of thrombolysis, PAI-1 is also associated with vascular inflammation. The role of other serpins that target thrombolytic proteases, PAI-2, PAI-3, and neuroserpin (NSP), in vascular inflammation is, however, less well defined. NSP is a mammalian serpin that, similar to PAI-1, inhibits urokinase- and tissue-type plasminogen activators (uPA and tPA, respectively) and has been most closely associated with the nervous system, with a demonst... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3247441 Tue, 02 Feb 2010 00:00:00 +0100 3247441 http://www.medworm.com/index.php?rid=3247440&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20135066%26dopt%3DAbstract Authors: Becker RC, Gurbel PA The platelet P2Y12 receptor is involved in all aspects of arterial thrombosis, including adhesion, activation, aggregation, secretion and development of a stable aggregate on which coagulation proteins can assemble and fibrin strands can mesh. Inhibition of the P2Y12 receptor has been shown convincingly to reduce cardiovascular events among patients with acute coronary syndromes (ACS) and in patients undergoing percutaneous intervention (PCI). Current studies are exploring whether there is a threshold of platelet aggregation below which only more bleeding occurs, without a concomitant reduction in clinical events. The following review considers the potential relevance of reversible and irreversible mechanisms of P2Y12 inhibition to bleeding risk, posing th... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3247440 Tue, 02 Feb 2010 00:00:00 +0100 3247440 http://www.medworm.com/index.php?rid=3247439&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20135067%26dopt%3DAbstract Authors: Miura M, Kaikita K, Matsukawa M, Soejima K, Fuchigami S, Miyazaki Y, Ono T, Uemura T, Tsujita K, Hokimoto S, Sumida H, Sugiyama S, Matsui K, Yamabe H, Ogawa H High plasma level of von Willebrand factor (VWF) is a marker of future cardiovascular events in patients at high risk of coronary artery disease (CAD). The purpose of this study was to examine the changes and the prognostic value of plasma VWF-cleaving protease (ADAMTS13) levels in patients with CAD. Plasma VWF and ADAMTS13 levels were measured in 225 patients with CAD (152 men and 73 women, age, 70.3 +/- 8.9 years, mean +/- SD) and 100 patients without CAD who were age- and gender-matched to the CAD patients (60 men and 40 women, age, 68.6 +/- 8.9 years). The CAD patients had higher VWF and lower ADAMTS13 antigen levels... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3247439 Tue, 02 Feb 2010 00:00:00 +0100 3247439 http://www.medworm.com/index.php?rid=3247438&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20135068%26dopt%3DAbstract Authors: Erpenbeck L, Rubant S, Hardt K, Santoso S, Boehncke WH, Schön MP, Ludwig RJ PMID: 20135068 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3247438 Tue, 02 Feb 2010 00:00:00 +0100 3247438 http://www.medworm.com/index.php?rid=3247437&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20135069%26dopt%3DAbstract Authors: Seested T, Nielsen HM, Christensen EI, Appa RS PMID: 20135069 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3247437 Tue, 02 Feb 2010 00:00:00 +0100 3247437 http://www.medworm.com/index.php?rid=3247436&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20135070%26dopt%3DAbstract Authors: Szlam F, Tanaka KA, Rumph B, Bolliger D, Levy JH PMID: 20135070 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3247436 Tue, 02 Feb 2010 00:00:00 +0100 3247436 http://www.medworm.com/index.php?rid=3247435&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20135071%26dopt%3DAbstract Authors: Ufer M Therapeutic oral anticoagulation is still commonly achieved by administration of warfarin or other vitamin K antagonists that are associated with an untoward pharmacokinetic / pharmacodynamic (PK/PD) profile leading to a high incidence of bleeding complications or therapeutic failure. Hence, there is an unmet medical need of novel easy-to-use oral anticoagulants with improved efficacy and safety. Recent developments include the identification of non-peptidic small-molecules that selectively inhibit certain serine proteases within the coagulation cascade. Of these, the thrombin inhibitor dabigatran and factor Xa inhibitor rivaroxaban have recently been licensed for thromboprophylaxis after orthopaedic surgery mainly in Europe. In addition, the factor Xa inhibitor apixaba... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3247435 Tue, 02 Feb 2010 00:00:00 +0100 3247435 http://www.medworm.com/index.php?rid=3247434&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20135072%26dopt%3DAbstract In conclusion, VTE risk varies according to medical diagnosis. Less than 40% of at-risk hospitalised medical patients receive ACCP-recommended prophylaxis. Prophylaxis use appears to be associated with disease severity rather than medical diagnosis. These data support the necessity to improve implementation of available guidelines for evaluating VTE risk and providing prophylaxis to hospitalised medical patients. PMID: 20135072 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3247434 Tue, 02 Feb 2010 00:00:00 +0100 3247434 http://www.medworm.com/index.php?rid=3247433&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20135073%26dopt%3DAbstract Authors: Eeckhoudt SL, Momeni M, Matta A, Latinne D, Arnout J, Hermans C PMID: 20135073 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3247433 Tue, 02 Feb 2010 00:00:00 +0100 3247433 http://www.medworm.com/index.php?rid=3247432&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20135074%26dopt%3DAbstract Authors: Ong KL, Tso AW, Cherny SS, Sham PC, Lam KS, Jiang CQ, Thomas GN, Lam TH, Cheung BM Fibrinogen, a major determinant of blood viscosity, is an acute phase protein associated with cardiovascular disease. We studied the association of hypertension with single nucleotide polymorphisms (SNPs) in the gene encoding the fibrinogen beta chain (FGB). Three tagging SNPs (rs1025154, rs4220 and rs1044291) were selected from the HapMap database on Han Chinese. Genotypes were determined in 1,294 unrelated subjects from the Hong Kong Cardiovascular Risk Factor Prevalence Study cohort. There were 199 hypertensive subjects at baseline. Among 1,095 subjects normotensive at baseline, 178 developed hypertension during a median follow-up period of 6.4 years. Among the three tagging SNPs, rs4220 show... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3247432 Tue, 02 Feb 2010 00:00:00 +0100 3247432 http://www.medworm.com/index.php?rid=3247431&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20135075%26dopt%3DAbstract Authors: Kubisz P, Plamenová I, Staško J, Dobrotová M, Hollý P PMID: 20135075 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3247431 Tue, 02 Feb 2010 00:00:00 +0100 3247431 http://www.medworm.com/index.php?rid=3247430&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20135076%26dopt%3DAbstract Authors: Becker RC, Povsic T, Cohen MG, Rusconi CP, Sullenger B Antithrombotic therapy for the acute management of thrombotic disorders has been stimulated and guided actively by our current understanding of platelet biology, coagulation proteases, and vascular science. A translatable platform for coagulation, based soundly on biochemistry, enzymology and cellular events on platelets and tissue factor-baring cells, introduces fundamental constructs, mechanistic clarity, and an unparalleled opportunity for accelerating the development and clinical investigation of both disease- and patient-specific therapies. In the current review, we build upon and expand substantially our observations surrounding nucleic acids as antithrombotic agents. PMID: 20135076 [PubMed - as supplied by publi... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3247430 Tue, 02 Feb 2010 00:00:00 +0100 3247430 http://www.medworm.com/index.php?rid=3247429&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20135077%26dopt%3DAbstract Authors: Gorin L, Fauchier L, Nonin E, de Labriolle A, Haguenoer K, Cosnay P, Babuty D, Charbonnier B In patients with atrial fibrillation (AF) and an intermediate risk of stroke (CHADS2 score =1), available evidence from clinical trials is inconclusive and the present guidelines for the management of AF indicate that the choice between oral anticoagulant and aspirin in these patients is open. Our goal was to evaluate whether, in patients with AF and only one moderate risk factor for thromboembolism, treatment with an oral anticoagulant is appreciably more beneficial than treatment with an antiplatelet agent. Among 6,517 unselected patients with AF, 1,012 of them (15.5%) had a CHADS2 score of 1 and were liable to treatment with an antiplatelet agent or an anticoagulant. An oral anticoa... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3247429 Tue, 02 Feb 2010 00:00:00 +0100 3247429 http://www.medworm.com/index.php?rid=3240273&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20126827%26dopt%3DAbstract Authors: Böhm-Weigert M, Wissel T, Muth H, Kemkes-Matthes B, Peetz D In vitro D-dimer stability in plasma is widely assumed, but has not yet been documented by systematic studies using samples covering a wide range of D-dimer. We investigated the short- and long-term stability of D-dimer in clinical citrated plasma samples with normal and pathological levels. The short-term stability was analysed by measuring D-dimer fresh, after storage of plasma for 4 hours at room temperature (RT) and after an additional 24 h storage at +2 to +8 degrees C (n=40). Long-term stability samples (n=40) were measured fresh and after storage for 19, 25 and 36 months at </=-60 degrees C. The effect of repeated freezing was analysed by measuring samples (n=50) fresh and after four consecutive freeze-... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3240273 Mon, 01 Feb 2010 00:00:00 +0100 3240273 http://www.medworm.com/index.php?rid=3240272&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20126828%26dopt%3DAbstract Authors: Kuhli-Hattenbach C, Scharrer I, Lüchtenberg M, Hattenbach LO Over the past years, there has been a dramatic increase in the number of identifiable causes of thrombophilia. However, to date, there are no large, prospective studies to assess an optimal, cost-effective approach with regard to screening and case finding for thrombophilic risk factors in patients presenting with retinal vessel occlusion. Two hundred twenty-eight patients with retinal vein occlusion (RVO) and 130 age-matched healthy controls were prospectively screened for thrombophilic risk factors. Both cohorts were divided into three subgroups, depending on the patients' age at the time of the RVO or a previous thromboembolic event. Patient age </=45 years was associated with a high prevalence of coagulat... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3240272 Mon, 01 Feb 2010 00:00:00 +0100 3240272 http://www.medworm.com/index.php?rid=3240271&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20126829%26dopt%3DAbstract Authors: Nissinen L, Pentikäinen OT, Jouppila A, Käpylä J, Ojala M, Nieminen J, Lipsanen A, Lappalainen H, Eckes B, Johnson MS, Lassila R, Marjamäki A, Heino J Interaction of blood platelets with vascular collagen is an initiating event in haemostasis and thrombus formation. Based on molecular modelling of human integrin alpha2I domain and cell-based screening assays we have developed sulfonamide derivatives, a mechanistically novel class of molecules. These molecules show antiplatelet efficacy by selectively inhibiting alpha2beta1 integrin-mediated collagen binding. One sulfonamide derivative, named BTT-3016, showed inhibitory capacity in several assessments of human platelet interaction with collagen. It inhibited about 90% of the aggregation of gel-filtered magne... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3240271 Mon, 01 Feb 2010 00:00:00 +0100 3240271 http://www.medworm.com/index.php?rid=3240270&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20126830%26dopt%3DAbstract Authors: Bouman HJ, van Werkum JW, Rudez G, Leebeek FW, Kruit A, Hackeng CM, Ten Berg JM, de Maat MP, Ruven HJ Novel P2Y12 inhibitors are in development to overcome the occurrence of atherothrombotic events associated with poor responsiveness to the widely used P2Y12 inhibitor clopidogrel. Cangrelor is an intravenously administered P2Y12 inhibitor that does not need metabolic conversion to an active metabolite for its antiplatelet action, and as a consequence exhibits a more potent and consistent antiplatelet profile as compared to clopidogrel. It was the objective of this study to determine the contribution of variation in the P2Y12 receptor gene to platelet aggregation after in vitro partial P2Y12 receptor blockade with the direct antagonist cangrelor. Optical aggregometry was perfor... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3240270 Mon, 01 Feb 2010 00:00:00 +0100 3240270 http://www.medworm.com/index.php?rid=3240269&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20126831%26dopt%3DAbstract Authors: Masoud M, Sarig G, Brenner B, Jacob G Prolonged standing activates the coagulation cascade by the activation of endothelial cells, and probably the haemoconcentration effect contributes to this "orthostatic hypercoagulability". It was the objective of this study to assess whether rehydration (haemodilution) prevents or attenuates orthostatic induced thrombin formation. Twelve healthy young subjects were studied during two separate visits. Haematocrit (Hct), total plasma protein, coagulation profile tests, including endothelial activation related factors, and protein C global pathway were studied at rest supine, and while standing at 15 and 30 minutes (min). During the second visit the study was repeated after intravenous 1.5 liter 0.9% saline. While in supine posture, intraven... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3240269 Mon, 01 Feb 2010 00:00:00 +0100 3240269 http://www.medworm.com/index.php?rid=3240268&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20126832%26dopt%3DAbstract Authors: Watson T, Shantsila E, Karthikeyan VJ, Jessani S, Goon PK, Lip GY Endothelial damage/dysfunction is involved in numerous cardiovascular disease processes. Given that the mature endothelial cells have limited capacity for self regeneration, circulating progenitor cells (CPCs) may modulate the balance between vascular damage and regeneration. The three aims of the present study were 1) to define the influence of exercise treadmill testing (ETT) on peripheral CPC levels; 2) to assess the diurnal variation of CPC counts; and 3) to investigate the rate of temporal decline in CPCs once ex vivo . The dynamics of CPC count changes following an ETT were assessed on consecutive 20 patients referred to our 'rapid-access' chest pain clinic (70% male, age 69.9 +/- 7.8) with venous blood sa... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3240268 Mon, 01 Feb 2010 00:00:00 +0100 3240268 http://www.medworm.com/index.php?rid=3240267&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20126833%26dopt%3DAbstract Authors: Brennan SO, Davis RL, Chitlur M PMID: 20126833 [PubMed - in process] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3240267 Mon, 01 Feb 2010 00:00:00 +0100 3240267 http://www.medworm.com/index.php?rid=3240266&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20126834%26dopt%3DAbstract Authors: Dietrich A, Kalwa H, Gudermann T The mammalian transient receptor potential (TRP) superfamily of non-selective cation channels can be divided into six major families. Among them, the "classical" or "canonical" TRPC family is most closely related to Drosophila TRP, the founding member of the superfamily. All seven channels of this family designated TRPC1-7 share the common property of receptor-operated activation through phospholipase C (PLC)-coupled receptors, but their regulation by store-dependent mechanisms involving the proteins STIM and ORAi is still discussed controversially. This review will focus on the proposed functions of TRPC proteins in cells of the vascular system (e.g. platelets, smooth muscle cells and endothelial cells) and will present data concerning their p... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3240266 Mon, 01 Feb 2010 00:00:00 +0100 3240266 http://www.medworm.com/index.php?rid=3240265&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20126835%26dopt%3DAbstract We examined the clinical characteristics and three-month outcome of all enrolled women with pregnancy, postpartum or using hormonal contraceptives. As of December 2008, 173 pregnant women, 135 postpartum, and 798 contraceptive users were enrolled. Of these, 438 (40%) presented with pulmonary embolism (PE) and 668 with deep-vein thrombosis (DVT). Most women with acute PE had dyspnea (72%) or chest pain (75%), but only 2.0% had hypoxaemia. During the three-month study period, five women (0.45%; 95% CI: 0.17-1.00) died (3 had fatal PE), 13 (1.18%; 95% CI: 0.66-1.95) had VTE recurrences, and seven (0.63%; 95% CI: 0.28-1.25) major bleeding. Two of the three women with fatal PE died during the first few hours after arriving at the emergency ward, with no time to start any therapy. The outcome of... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3240265 Mon, 01 Feb 2010 00:00:00 +0100 3240265 http://www.medworm.com/index.php?rid=3240264&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20126836%26dopt%3DAbstract Authors: Boudreaux MK, Wardrop KJ, Kiklevich V, Felsburg P, Snekvik K PMID: 20126836 [PubMed - in process] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3240264 Mon, 01 Feb 2010 00:00:00 +0100 3240264 http://www.medworm.com/index.php?rid=3240263&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20126837%26dopt%3DAbstract Authors: Squizzato A, Manfredi E, Bozzato S, Dentali F, Ageno W Optimal management of retinal vein occlusion (RVO) is still a matter of debate. Antithrombotic and fibrinolytic drugs have been investigated after demonstration of a role of thrombosis in the complex pathogenesis of the disease. Aim of our study was to systematically summarise best available evidence on the acute treatment and on the secondary prevention of RVO with antithrombotic and fibrinolytic drugs. A computer-assisted search of the MEDLINE and EMBASE electronic databases up to January 2009 was performed. Two review authors selected all published randomised controlled trials (RCTs) from the search, assessed study quality and extracted data. Based on Jadad's score, RCTs were stratified into three quality categories. A ... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3240263 Mon, 01 Feb 2010 00:00:00 +0100 3240263 http://www.medworm.com/index.php?rid=3240262&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20126838%26dopt%3DAbstract This study was the first in a decade to challenge clopidogrel monopoly, and to indirectly test the "resistance" hypothesis. The primary endpoint was the rate of cardiovascular death, non-fatal myocardial infarction, or stroke, and occurred in 12.1% of patients treated with clopidogrel, and 9.9% of patients randomised to prasugrel, suggesting impressive vascular outcome benefit of prasugrel over clopidogrel. However, the Food and Drug Administration (FDA) presented more balanced, and realistic outlook on TRITON. While very early periprocedural benefit exists, long-term prasugrel therapy yielded identical to clopidogrel vascular outcomes among 13,608 TRITON patients challenging the postulate that clopidogrel "resistance" phenomenon is clinically relevant. Despite the fact that prasugrel 10 m... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3240262 Mon, 01 Feb 2010 00:00:00 +0100 3240262 http://www.medworm.com/index.php?rid=3240261&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20126839%26dopt%3DAbstract Authors: Fiumara K, Piovella C, Hurwitz S, Piazza G, Niles CM, Fanikos J, Paterno M, Labreche M, Stevens LA, Baroletti S, Goldhaber SZ Venous thromboembolism (VTE) prophylaxis in high-risk patients is frequently underutilised. We previously devised a one-screen computer alert program that identified hospitalised patients at high risk for VTE who were not receiving prophylaxis and advised their physicians to prescribe prophylaxis. While this strategy reduced the 90-day incidence of symptomatic VTE by 41%, the majority of electronic alerts were ignored. We have now developed a serial three-screen alert computer program designed to educate physicians who initially declined to order prophylaxis after a single screen alert. Of a total cohort of 880, the responsible physicians for 425 patien... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3240261 Mon, 01 Feb 2010 00:00:00 +0100 3240261 http://www.medworm.com/index.php?rid=3179593&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20076840%26dopt%3DAbstract Authors: Subramanian P, Schober A PMID: 20076840 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3179593 Wed, 13 Jan 2010 00:00:00 +0100 3179593 http://www.medworm.com/index.php?rid=3179592&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20076841%26dopt%3DAbstract In conclusion, platelet activation is increased in pregnancy and increases with gestation but is unaffected by pre-eclampsia. This suggests that systemic platelet activation is a feature of pregnancy but this is not affected by established pre-eclampsia. PMID: 20076841 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3179592 Wed, 13 Jan 2010 00:00:00 +0100 3179592 http://www.medworm.com/index.php?rid=3179591&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20076842%26dopt%3DAbstract Authors: Strauss T, Levy-Shraga Y, Ravid B, Schushan-Eisen I, Maayan-Metzger A, Kuint J, Kenet G Evaluation of clot formation in neonates is troublesome. Our aim was to investigate cord blood clot formation of pre-term versus full-term infants and adults, using rotating thromboelastogram (ROTEM(R), Pentafarm, Munich, Germany). ROTEM was investigated in cord blood of 184 full-term and 47 pre-term infants. Measurements of the clotting time (CT), clot formation time (CFT) and maximal clot firmness (MCF) were obtained in order to asses reference values for this age group, and compare between full-term and pre-term neonates and compared to adult controls. For each infant demographic information and data regarding pregnancy and delivery were gathered. Infants were prospectively followed unti... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3179591 Wed, 13 Jan 2010 00:00:00 +0100 3179591 http://www.medworm.com/index.php?rid=3179590&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20076843%26dopt%3DAbstract Authors: Pengo V, Cucchini U, Denas G, Davidson BL, Marzot F, Padayattil Jose S, Iliceto S It has been observed that elderly patients with nonvalvular atrial fibrillation (NVAF) benefit from standard [an international normalised ratio (INR) goal of 2.0-3.0] oral anticoagulant treatment (OAT). The hypothesis that lower-intensity anticoagulation therapy can offset the higher bleeding risk in this population has never been tested in an 'ad hoc' clinical trial. Patients over 75 years of age with NVAF were randomised to receive warfarin to maintain the INR at 1.8 (range 1.5-2.0) or at a standard target of 2.5 (range 2.0-3.0). There were 135 patients in the low-intensity and 132 in the standard-intensity groups. During a mean follow-up lasting 5.1 years, 59 primary outcome events (thromboemb... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3179590 Wed, 13 Jan 2010 00:00:00 +0100 3179590 http://www.medworm.com/index.php?rid=3179589&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20076844%26dopt%3DAbstract Authors: Weiss TW, Furenes EB, Trøseid M, Solheim S, Hjerkinn EM, Seljeflot I, Arnesen H PMID: 20076844 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3179589 Wed, 13 Jan 2010 00:00:00 +0100 3179589 http://www.medworm.com/index.php?rid=3179588&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20076845%26dopt%3DAbstract Authors: Zuern CS, Geisler T, Gawaz M The dual antiplatelet therapy consisting of aspirin and the ADP-receptor blocker clopidogrel is the current standard medication after acute coronary events. However, clopidogrel is characterised by a high interindividual response variability, insufficient inhibition of platelet aggregation in a significant number of patients, relatively slow onset of efficacy and potential interaction with different co-medication via diverse hepatic cytochrome enzymes. In various trials, response variability of clopidogrel was translated into a higher rate of recurrent cardiovascular events. Different clinical and non-genetic factors contribute to the phenomenon of clopidogrel response variability. An individualised antithrombotic pharmacotherapy taking these facto... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3179588 Wed, 13 Jan 2010 00:00:00 +0100 3179588 http://www.medworm.com/index.php?rid=3179587&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20076846%26dopt%3DAbstract In conclusion, the independent and concentration-dependent association of macrophage-modulating cytokines and in particular of M-CSF with adverse outcome in advanced HF patients suggests that these cytokines may play an important pathophysiological role in progression of cardiomyopathy. PMID: 20076846 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3179587 Wed, 13 Jan 2010 00:00:00 +0100 3179587 http://www.medworm.com/index.php?rid=3179586&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20076847%26dopt%3DAbstract In conclusion, the 807T allele of GP Ia and the PlA2 allele of GP IIIa, and specially its combination, may confer an additional risk for development of carotid atherosclerosis and arterial thrombosis in type 2 diabetes. PMID: 20076847 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3179586 Wed, 13 Jan 2010 00:00:00 +0100 3179586 http://www.medworm.com/index.php?rid=3179585&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20076848%26dopt%3DAbstract In conclusion, early after CABG, the incidence of residual platelet activity was lower in patients who received 325 mg aspirin. Moreover, evidence was provided that different methods yield different results in the detection of aspirin resistance, rendering them not interchangeable. PMID: 20076848 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3179585 Wed, 13 Jan 2010 00:00:00 +0100 3179585 http://www.medworm.com/index.php?rid=3179584&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20076849%26dopt%3DAbstract Authors: Kappert K, Furundzija V, Fritzsche J, Margeta C, Krüger J, Meyborg H, Fleck E, Stawowy P Integrins link the cytoskeleton to the extracellular matrix, providing outside-in/inside-out signalling essential for vascular smooth muscle cell (VSMC) migration in atherosclerosis. The integrin av subunit is synthesised from its precursor via furin-dependent endoproteolytic cleavage. Furin is a proprotein convertase (PC) highly expressed in VSMCs and in human atherosclerotic lesions. Inhibition of av processing inhibits binding to vitronectin and migration. However, the precise role of furin-dependent av cleavage on integrin bidirectional signalling and subsequent VSMC functions is unknown. Our present study demonstrates that the furin-like PC inhibitor decanoyl-RVKR-chloromethylket... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3179584 Wed, 13 Jan 2010 00:00:00 +0100 3179584 http://www.medworm.com/index.php?rid=3179583&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20076850%26dopt%3DAbstract In conclusion, the safety and tolerability of 150mg bid immediate-release AZD0837 appeared to be as good as that of dose-adjusted warfarin. However, larger studies will be needed to define the safety profile of AZD0837. PMID: 20076850 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3179583 Wed, 13 Jan 2010 00:00:00 +0100 3179583 http://www.medworm.com/index.php?rid=3179582&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20076851%26dopt%3DAbstract In conclusion, combined cardiac BM-MNC delivery induces significant improvement in myocardial viability and perfusion in the intramyocardially injected area. PMID: 20076851 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3179582 Wed, 13 Jan 2010 00:00:00 +0100 3179582 http://www.medworm.com/index.php?rid=3179581&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20076852%26dopt%3DAbstract Authors: Lukasik M, Rozalski M, Luzak B, Michalak S, Kozubski W, Watala C The study was aimed at the evaluation of blood platelet activation and reactivity in patients in the convalescent phase of stroke (n=58) and controls matched in respect to risk factors of vascular pathology (n=55). Both groups were treated daily with acetylsalicylic acid (ASA), 150 mg/day. Using flow cytometry, the expressions of P-selectin and the active GP IIb/IIIa receptor, as well as the fraction of platelet-derived microparticles (PMPs) and total platelet aggregates (Ag), were evaluated in non-stimulated platelets and in platelets stimulated in vitro by thrombin, thrombin receptor activating peptide (TRAP) or ADP. The expression of P-selectin in non-stimulated platelets was found to be significantly (p=0.04)... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3179581 Wed, 13 Jan 2010 00:00:00 +0100 3179581 http://www.medworm.com/index.php?rid=3179580&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20076853%26dopt%3DAbstract In conclusion, the mechanisms responsible for this complication of anti-aIIbb3 therapy are multiple and often associated with a complex immune response. PMID: 20076853 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3179580 Wed, 13 Jan 2010 00:00:00 +0100 3179580 http://www.medworm.com/index.php?rid=3179579&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20076854%26dopt%3DAbstract Authors: Iorio A, Fabbriciani G, Marcucci M, Brozzetti M, Filipponi P Osteoporosis is caused by bone mineral density (BMD) reduction. Haemophilia patients are at increased risk of osteoporosis because of decreased physical activity and blood-borne virus infections. This systematic review of the literature aims at evaluating BMD reduction in severe haemophilia patients and its correlation with patients' characteristics. Seven case-control studies evaluating lumbar BMD values [g/cm2] (all studies), BMI (5/7 studies), and hepatitis C virus (HCV) seropositivity (6/7 studies) in severe haemophilia patients and controls were meta-analysed. Standardised mean difference (SMD) of BMD was used to compare cases and controls. The effect of body mass index (BMI) and HCV infection was investigated b... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3179579 Wed, 13 Jan 2010 00:00:00 +0100 3179579 http://www.medworm.com/index.php?rid=3179578&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20076855%26dopt%3DAbstract Authors: Sofi F, Cesari F, Abbate R, Gensini GF, Broze GJ, Fedi S The relationship between protein Z levels and thrombosis is controversial. We performed a systematic review and meta-analysis of the available studies to assess the association between protein Z and vascular thrombotic diseases. We conducted an electronic literature search through MedLine, Embase, Google Scholar, Web of Science, The Cochrane Library, bibliographies of retrieved articles and abstracts of congresses up to October, 2009. Studies were included if they analysed protein Z levels in patients with vascular thrombotic diseases. After the review process, 28 case-control studies (33 patient cohorts), including 4,218 patients with thrombotic diseases and 4,778 controls, were selected for analysis. The overall analys... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3179578 Wed, 13 Jan 2010 00:00:00 +0100 3179578 http://www.medworm.com/index.php?rid=3179577&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20076856%26dopt%3DAbstract This study's aim was to investigate progenitor cells mobilised during myocardial infarction after treatment with granulocyte-stimulating factor (G-CSF). In the randomised, double-blind, placebo-controlled REVIVAL-2 study, 114 patients with acute myocardial infarction were included. Five days after successful percutaneous coronary intervention patients received either 10 microg/kg G-CSF (n=56) or placebo (n=58) subcutaneously for five days. Venous blood samples were analysed on day(s) 1, 3, 5 and 7 after therapy, and progenitor cell mobilisation and surface expression of VLA-4, LFA-1 and CXCR-4 was measured on circulating progenitor cells using flow cytometry. G-CSF induced a significant increase in circulating progenitor cells (72 +/- 20 cells/microl vs. 4.5 +/- 0.8 cells/microl, p<0.05... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3179577 Wed, 13 Jan 2010 00:00:00 +0100 3179577 http://www.medworm.com/index.php?rid=3179576&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20076857%26dopt%3DAbstract Authors: Eikelboom JW, Weitz JI PMID: 20076857 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3179576 Wed, 13 Jan 2010 00:00:00 +0100 3179576 http://www.medworm.com/index.php?rid=3179575&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20076858%26dopt%3DAbstract Authors: Lane DA, Lip GY PMID: 20076858 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3179575 Wed, 13 Jan 2010 00:00:00 +0100 3179575 http://www.medworm.com/index.php?rid=3167667&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20062913%26dopt%3DAbstract Authors: Gonzalez-Porras JR, Martin-Herrero F, Gonzalez-Lopez TJ, Olazabal J, Diez-Campelo M, Pabon P, Alberca I, San Miguel JF PMID: 20062913 [PubMed - in process] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3167667 Fri, 01 Jan 2010 00:00:00 +0100 3167667 http://www.medworm.com/index.php?rid=3167666&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20062914%26dopt%3DAbstract Authors: Muhlestein JB Inflammation is central to the pathogenesis and progression of atherosclerosis and thrombosis, the underlying cause of major cardiovascular disease. Platelets, in addition to their role in haemostasis, play a key role in both thrombus formation and inflammation following vascular injury, especially atherosclerotic lesions. An increasing body of evidence suggests that inhibition of platelet function can modulate inflammatory markers, particularly those associated with activated platelets, such as CD40 ligand, P-selectin, and C-reactive protein. The currently available antiplatelet agents aspirin, clopidogrel, prasugrel, abciximab, and eptifibatide have shown varying effects on inflammatory markers. These effects seem to be mostly indirect, i.e. mediated primarily ... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3167666 Fri, 01 Jan 2010 00:00:00 +0100 3167666 http://www.medworm.com/index.php?rid=3167665&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20062915%26dopt%3DAbstract In conclusion, rivaroxaban was well tolerated and was found to have predictable PK and PD in healthy, elderly Chinese subjects. PMID: 20062915 [PubMed - in process] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3167665 Fri, 01 Jan 2010 00:00:00 +0100 3167665 http://www.medworm.com/index.php?rid=3167664&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20062916%26dopt%3DAbstract Authors: Löwenberg EC, Charunwatthana P, Cohen S, van den Born BJ, Meijers JC, Yunus EB, Hassan MU, Hoque G, Maude RJ, Nuchsongsin F, Levi M, Dondorp AM Severe falciparum malaria remains a major killer in tropical countries. Central in the pathophysiology is mechanical obstruction in the microcirculation caused by cytoadherence and sequestration of parasitized erythrocytes. However, the pathogenesis of many features complicating severe malaria, including coma, renal failure and thrombocytopenia, remains incompletely understood. These disease manifestations are also key features of thrombotic thrombocytopenic purpura, a life-threatening disease strongly associated with a deficiency of the von Willebrand factor (VWF) cleaving protease, ADAMTS13. We measured plasma ADAMTS13 activity,... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3167664 Fri, 01 Jan 2010 00:00:00 +0100 3167664 http://www.medworm.com/index.php?rid=3167663&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20062917%26dopt%3DAbstract Authors: Kretz CA, Cuddy KK, Stafford AR, Fredenburgh JC, Roberts R, Weitz JI HD1, a DNA aptamer, binds exosite 1 on thrombin and blocks its clotting activity. Because HD1 also binds prothrombin and inhibits its activation by prothrombinase, we hypothesised that HD1 would be a more potent inhibitor of coagulation than other exosite 1-directed ligands, such as Hir54-65(SO3-). Supporting this concept, the effect of HD1 on the prothrombin time and activated partial thromboplastin time was two-fold greater than that of Hir54-65(SO3-) even though both agents inhibited thrombin-mediated factor (F) V and FVIII activation to a similar extent. In thrombin generation assays, HD1 (a) delayed the lag time, (b) reduced peak thrombin concentration, and (c) decreased endogenous thrombin potential to ... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3167663 Fri, 01 Jan 2010 00:00:00 +0100 3167663 http://www.medworm.com/index.php?rid=3167662&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20062918%26dopt%3DAbstract Authors: Pouplard C, Leroux D, Regina S, Rollin J, Gruel Y The diagnosis of heparin-induced thrombocytopenia (HIT) is based on clinical criteria and biological assays. Most immunoassays detect antibodies (either IgG alone or additionally IgA and IgM) against PF4 immobilised in wells of microtiter plates with stoichiometric concentrations of polyanion (heparin or polyvinylsulfonate). We studied whether diagnostic sensitivity and/or specificity for HIT could be improved using a novel assay in which unfractionated heparin is immobilised alone to the microwells, with PF4 (and, potentially, other heparin-dependent antigen proteins) provided by adding platelet lysate during the procedure. Samples from 101 patients with suspected HIT and from 101 controls (including 50 with antiphospholipid a... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3167662 Fri, 01 Jan 2010 00:00:00 +0100 3167662 http://www.medworm.com/index.php?rid=3167661&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20062919%26dopt%3DAbstract Authors: Sibbing D, Morath T, Braun S, Stegherr J, Mehilli J, Vogt W, Schömig A, Kastrati A, von Beckerath N Clopidogrel low-responsiveness assessed with multiple electrode platelet aggregometry (MEA) has been shown to be a strong and independent predictor of early stent thrombosis (ST) after coronary stenting. The relation of clopidogrel response status, as assessed with MEA, with incidence and timing of ST during an extended follow-up period has never been reported. Here, we report the six-month follow-up results of a prospective trial assessing clopidogrel responsiveness with MEA in patients undergoing percutaneous coronary intervention (PCI). A total of 1,608 consecutive patients with planned drug-eluting stent placement were enrolled in this study. Before PCI patients uniform... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3167661 Fri, 01 Jan 2010 00:00:00 +0100 3167661 http://www.medworm.com/index.php?rid=3167660&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20062920%26dopt%3DAbstract In conclusion, ASA-resistant and ASA-sensitive platelets are different in terms of the level of expression of proteins associated with mechanisms such as energetic metabolism, cytoskeleton, oxidative stress and cell survival which may be associated with their different ability to respond to ASA. PMID: 20062920 [PubMed - in process] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3167660 Fri, 01 Jan 2010 00:00:00 +0100 3167660 http://www.medworm.com/index.php?rid=3167659&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20062921%26dopt%3DAbstract Authors: Metassan S, Charlton AJ, Routledge MN, Scott DJ, Ariens RA Both long- and short-term (1-2 hours) exposure to particulate matter (PM) are associated with morbidity and mortality caused by cardiovascular diseases. One of the underlying mechanisms may be due to changes to blood coagulability upon exposure to PM. We investigated this possibility by measuring differences in blood clots formed in the presence of particulate matter in vitro. Total (T)PM increased the permeation of clots in a dose-dependant manner. Filtered (F)PM (17 mug/ml) also produced a significant increase in permeation. Turbidity measured as maximum optical density (ODmax) was increased in a dose-dependant manner with increasing concentration of TPM and FPM. Turbidity measurements also showed a significantly fas... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3167659 Fri, 01 Jan 2010 00:00:00 +0100 3167659 http://www.medworm.com/index.php?rid=3167658&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20062922%26dopt%3DAbstract Authors: Takeyama M, Nogami K, Matsumoto T, Soeda T, Suzuki T, Hattori K, Shima M Many reports have identified factor (F)VIII inhibitory antibodies with epitopes located in all subunits of the FVIII molecule. Antibodies that promote FVIII activity do not appear to have been reported. We characterised, for the first time, a unique anti-FVIII monoclonal antibody, mAb216, that enhanced FVIII coagulant activity. The mAb216 shortened the activated partial thromboplastin time and specifically increased FVIII activity by ~1.5-fold dose-dependently. FXa generation and thrombin generation were similarly increased by ~1.4- and ~2.5-fold, respectively. An A2 epitope, not overlapping the common A2 epitope, was identified and the antibody was shown to enhance thrombin (and FXa)-catalysed activation... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3167658 Fri, 01 Jan 2010 00:00:00 +0100 3167658 http://www.medworm.com/index.php?rid=3167657&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20062923%26dopt%3DAbstract Authors: Blondon M, Perrier A, Nendaz M, Righini M, Boehlen F, Boulvain M, De Moerloose P Although venous thromboembolism (VTE) is the leading cause of maternal mortality in developed countries, the usefulness of preventive low-molecular-weight heparin (LMWH) after cesarean delivery remains a matter of controversy. It was the objective of this study to evaluate the usefulness of thromboprophylaxis with LMWH after cesarean delivery. A decision model was constructed to evaluate the risks and benefits associated with a seven-day LMWH prophylaxis, compared with none. All probabilities were obtained from literature according to the highest level of evidence. We performed our analysis on two different sets of outcomes (utilities and disutilities), to calculate the quality-adjusted life expec... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3167657 Fri, 01 Jan 2010 00:00:00 +0100 3167657 http://www.medworm.com/index.php?rid=3167656&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20062924%26dopt%3DAbstract Authors: Segers O, van Oerle R, Ten Cate H, Rosing J, Castoldi E In vitro thrombin generation, which reflects an individual's plasma coagulation potential and has been shown to correlate with the risk of venous thromboembolism (VTE), might represent a useful intermediate phenotype for the genetic dissection of VTE. As a proof of principle, we have investigated whether the thrombin generation assay can detect changes in the haemostatic balance associated with common genetic variation affecting the level or function of coagulation factors and inhibitors. The study population consisted of 140 healthy individuals. Plasma levels of coagulation factors and inhibitors and thrombin generation parameters determined at low tissue factor (TF) +/- thrombomodulin (TM) and at high TF +/- activated p... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3167656 Fri, 01 Jan 2010 00:00:00 +0100 3167656 http://www.medworm.com/index.php?rid=3167655&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20062925%26dopt%3DAbstract Authors: Phillips KW, Ansell J PMID: 20062925 [PubMed - in process] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3167655 Fri, 01 Jan 2010 00:00:00 +0100 3167655 http://www.medworm.com/index.php?rid=3167654&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20062926%26dopt%3DAbstract Authors: Stein PD, Matta F, Yaekoub AY, Ahsan ST, Badshah A, Younas F, Denier JE The effects of graduated compression stockings (GCS) on venous blood velocity have not been established. In healthy subjects, most investigations showed no effect on blood velocity, but mixed results have been reported. In this investigation we to test the hypothesis that popliteal blood velocity is increased by properly fitted GCS. Time average peak velocity in the popliteal vein, as well as time average mean velocity, vein diameter and mean volumetric flow were measured by pulsed wave Doppler ultrasound in 25 healthy male volunteers without compression stockings and repeated with fitted thigh-length compression stockings. Measurements were obtained while supine and while sitting at rest and during ankle ... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3167654 Fri, 01 Jan 2010 00:00:00 +0100 3167654 http://www.medworm.com/index.php?rid=3167653&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20062927%26dopt%3DAbstract Authors: Williams CD, Cherala G, Serebruany VL The ability to test platelet reactivity in clinical practice could help in making informed decisions on both initiation and titration of anti-platelet drug therapies. However, many barriers still remain to the effective implementation of such techniques. Many tests used in the research literature are not yet available for practical, clinical use. Platelet aggregometry, while informative and currently available for bedside use, needs additional research before routine clinical use can be recommended. This review will highlight and update contemporary issues of bedside platelet testing for the clinician and comment on future areas of clinical research. PMID: 20062927 [PubMed - in process] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3167653 Fri, 01 Jan 2010 00:00:00 +0100 3167653 http://www.medworm.com/index.php?rid=3167652&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20062928%26dopt%3DAbstract Authors: Zafar MU, Ibanez B, Choi BG, Vorchheimer DA, Piñero A, Jin X, Sharma RK, Badimon JJ DZ-697b is a new orally active antiplatelet agent that inhibits collagen and ristocetin-mediated platelet activation. It does not require metabolisation to generate its active compound and has a safer profile than clopidogrel in pre-clinical studies. We compared the antithrombotic effects and bleeding time prolongations of three DZ-697b doses with clopidogrel 300 mg. In a four-treatment, three-period, crossover-design, 20 healthy subjects (31 +/- 7 years, 85% males) were randomised to single oral doses of DZ-697b (60, 120 and 360 mg), and clopidogrel (300 mg) (n=15 in each treatment with crossing-over). Antithrombotic effects were assessed by measuring six-hour post-dose changes from basel... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3167652 Fri, 01 Jan 2010 00:00:00 +0100 3167652 http://www.medworm.com/index.php?rid=3167651&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20062929%26dopt%3DAbstract In this study, we evaluate whether a human/mouse chimeric monoclonal antibody (ALT-836, formerly known as Sunol-cH36) blocking the factor X/factor IX (FX/FIX) binding site of tissue factor could achieve similar clinical benefits in an arterial thrombosis model induced by surgical endarterectomy in chimpanzees. In this model, sequential surgical endarterectomies on right and left superficial femoral arteries were performed 30 days apart in five chimpanzees. A bolus (1 mg/kg) of ALT-836 was injected intravenously immediately preceding the restoration of flow in the endarterectomised femoral artery. Pre-surgical labelling of autologous platelets using 111In-Oxine and post-surgical gamma camera imaging of 111In-platelet deposition at endarterectomy sites was performed. The manipulated arterial... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3167651 Fri, 01 Jan 2010 00:00:00 +0100 3167651 http://www.medworm.com/index.php?rid=3167650&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20062930%26dopt%3DAbstract Authors: Beckers CM, van Hinsbergh VW, van Nieuw Amerongen GP In the past decade understanding of the role of the Rho GTPases RhoA, Rac1 and Cdc42 has been developed from regulatory proteins that regulate specific actin cytoskeletal structures - stress fibers, lamellipodia and filopodia - to complex integrators of cytoskeletal structures that can exert multiple functions depending on the cellular context. Fundamental to these functions are three-dimensional complexes between the individual Rho GTPases, their specific activators (GEFs) and inhibitors (GDIs and GAPs), which greatly outnumber the Rho GTPases themselves, and additional regulatory proteins. By this complexity of regulation different vasoactive mediators can induce various cytoskeletal structures that enable the endothelial ... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3167650 Fri, 01 Jan 2010 00:00:00 +0100 3167650 http://www.medworm.com/index.php?rid=3167649&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20062931%26dopt%3DAbstract Authors: Douma RA, Hofstee HM, Schaefer-Prokop C, van Waesberghe JH, Lely RJ, Kamphuisen PW, Gerdes VE, Kramer MH, Büller HR With the introduction of multi-detector row CT (MDCT), sensitivity to diagnose pulmonary embolism (PE) has greatly improved. The use of newer generation CT-scans may lead to a higher prevalence and a different distribution of PE. We compared 64-slice with 4-slice MDCT regarding prevalence and distribution of PE, the number of inconclusive test results and inter-reader variability. CT-scans from a random sample of 110 consecutive patients who underwent 4-slice CT-scanning were compared with 64-slice CT-scans from 107 patients from a second cohort. Three radiologists independently reassessed all CT-scans. Consensus was reached in case of disagreement between t... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3167649 Fri, 01 Jan 2010 00:00:00 +0100 3167649 http://www.medworm.com/index.php?rid=3167648&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20062932%26dopt%3DAbstract Authors: Sierko E, Wojtukiewicz MZ, Zimnoch L, Kisiel W Activation of blood coagulation, a phenomenon frequently observed in breast and colon cancer patients, contributes to tumour progression. The principal initiator of blood coagulation activation in cancer patients is tissue factor (TF), while tissue factor pathway inhibitor (TFPI) is the main inhibitor of the TF-dependent pathway of blood coagulation. Previous immunohistochemical studies revealed no expression of TFPI in human cancer cells. The aim of the study was to evaluate the expression of TFPI protein and mRNA in breast and colon cancer tissues. A total of 108 cancer tissues (from primary tumours and metastatic lymph nodes) were obtained from 87 patients during surgical treatment. Immunohistochemical studies using a polyclona... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3167648 Fri, 01 Jan 2010 00:00:00 +0100 3167648 http://www.medworm.com/index.php?rid=3167647&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20062933%26dopt%3DAbstract Authors: Barzelay A, Ben-Shoshan J, Entin-Meer M, Maysel-Auslender S, Afek A, Barshack I, Keren G, George J The LIM-homeobox transcription factor islet-1 (Isl1) marks a cell population which gives rise to myocardial, pacemaker, endothelial and smooth muscle cells, which are derived from the secondary heart field during heart embryogenesis. Isl1+ precursors have the potential of self-renewal and differentiation into endothelial, cardiomyocyte and smooth muscle lineages. The primary objective of this study was to determine whether retroviral gene delivery of Isl1 to endothelial cells and mesenchymal stem cells (MSCs) could promote angiogenic and vasculogenic properties. To this end, endothelial cells and rat MSCs were retrovirally transduced to express Isl1. Isl1 expression in endothelia... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3167647 Fri, 01 Jan 2010 00:00:00 +0100 3167647 http://www.medworm.com/index.php?rid=3167646&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20062934%26dopt%3DAbstract Authors: Weitz JI Although currently available anticoagulants are effective for the prevention and treatment of thromboembolic disorders, they have several drawbacks. Low-molecular-weight heparins and fondaparinux produce a predictable level of anticoagulation that obviates the need for coagulation monitoring, but they must be given parenterally, which renders them inconvenient for long-term use. Vitamin K antagonists, such as warfarin, are administered orally, but produce a variable anticoagulant response because genetic polymorphisms, dietary vitamin K intake and multiple drug-drug interactions affect their metabolism. Consequently, coagulation monitoring and frequent dose adjustments are needed to ensure that a therapeutic level of anticoagulation is achieved. This is burdensome for... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3167646 Fri, 01 Jan 2010 00:00:00 +0100 3167646 http://www.medworm.com/index.php?rid=3167645&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20062935%26dopt%3DAbstract Authors: Kerr J, Linkins LA The in-hospital incidence of pulmonary embolism (PE) in patients undergoing elective joint arthroplasty who receive a minimum of 10 days of dalteparin prophylaxis is reported to be less than 1%. Recent clinical experience raised suspicion that the incidence of PE was significantly higher at our tertiary care institution. It was the objective of this study to determine the incidence of in-hospital PE and symptomatic deep-vein thrombosis following elective joint arthroplasty in patients who received a minimum of 10 days of dalteparin prophylaxis. Consecutive charts of patients who underwent elective joint arthroplasty at our institution between January 2008 and June 2008 were reviewed. Data on risk factors for venous thromboembolism, objectively documented ven... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3167645 Fri, 01 Jan 2010 00:00:00 +0100 3167645 http://www.medworm.com/index.php?rid=3167644&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20062936%26dopt%3DAbstract The objective of this study was to evaluate the antiplatelet effect of a prasugrel 10-mg MD versus a clopidogrel 150-mg MD in patients with ACS who had received a clopidogrel 900-mg LD. Patients with non-ST elevation ACS, treated with aspirin and a clopidogrel 900-mg LD, were randomised within 24 hours post-LD to receive a prasugrel 10-mg or clopidogrel 150-mg MD. After 14 days of the initial MD, subjects switched to the alternative treatment for 14 days. The primary endpoint compared maximum platelet aggregation (MPA, 20 microM adenosine diphosphate [ADP]) between prasugrel and clopidogrel MDs for both periods. Responder analyses between treatments were performed using several platelet-function methods. Of 56 randomised subjects, 37 underwent PCI. MPA was 26.2% for prasugrel 10 mg and 39.... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3167644 Fri, 01 Jan 2010 00:00:00 +0100 3167644 http://www.medworm.com/index.php?rid=3167643&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20062937%26dopt%3DAbstract Authors: Doutremepuich C, Aguejouf O, Desplat V, Eizayaga FX Aspirin remains the most widely used drug for prevention of vascular events. Recent observational epidemiological evidence has raised the concern that aspirin withdrawal for treatment non-compliance, surgery or side effects can carry an increased thrombotic risk. The delay to the thrombotic event was between 7 to 30 days in most reports and most frequently 7 to 10 days. The mechanism underlying this effect remains poorly understood. Using an in vivo model of laser-induced thrombosis, aspirin injected in one single dose of 100 mg/kg bw has also shown a prothrombotic activity in the rat 8 to 10 days after injection in the normal rat. The hypothesis was made that minimal concentrations of aspirin or ultra-low dose aspirin (ULDA)... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3167643 Fri, 01 Jan 2010 00:00:00 +0100 3167643 http://www.medworm.com/index.php?rid=3167642&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20062938%26dopt%3DAbstract Authors: Gresele P, Momi S, Migliacci R The association between venous thromboembolism and arterial thrombosis has emerged as consistent clinical observation in the last few years. While several experimental, epidemiological and pharmacologic studies support this association, the initial pathophysiological mechanism linking these two clinical conditions remains to be established. This review discusses the pathophysiological bases and a number of experimental and clinical observations suggesting that the common link between venous thromboembolism and arterial thrombosis is represented by a dysfunctional endothelium. PMID: 20062938 [PubMed - in process] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3167642 Fri, 01 Jan 2010 00:00:00 +0100 3167642 http://www.medworm.com/index.php?rid=3167641&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20062939%26dopt%3DAbstract Authors: Lip GY, Huber K, Andreotti F, Arnesen H, Airaksinen KJ, Cuisset T, Kirchhof P, Marín F There remains uncertainty over optimal antithrombotic management strategy for patients with atrial fibrillation (AF) presenting with an acute coronary syndrome and/or undergoing percutaneous coronary intervention/stenting. Clinicians need to balance the risk of stroke and thromboembolism against the risk of recurrent cardiac ischaemia and/or stent thrombosis, and the risk of bleeding. This consensus document comprehensively reviews the published evidence and presents a consensus statement on a 'best practice' antithrombotic therapy guideline for the management of antithrombotic therapy in such AF patients. PMID: 20062939 [PubMed - in process] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3167641 Fri, 01 Jan 2010 00:00:00 +0100 3167641 http://www.medworm.com/index.php?rid=3167640&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20062940%26dopt%3DAbstract Authors: Marín F, Bonacasa B, Valdés M PMID: 20062940 [PubMed - in process] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3167640 Fri, 01 Jan 2010 00:00:00 +0100 3167640 http://www.medworm.com/index.php?rid=3167639&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20062941%26dopt%3DAbstract Authors: Ott I PMID: 20062941 [PubMed - in process] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3167639 Fri, 01 Jan 2010 00:00:00 +0100 3167639 http://www.medworm.com/index.php?rid=3167638&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20062942%26dopt%3DAbstract Authors: Weber C, Lip GY PMID: 20062942 [PubMed - in process] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3167638 Fri, 01 Jan 2010 00:00:00 +0100 3167638 http://www.medworm.com/index.php?rid=3167637&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20062943%26dopt%3DAbstract Authors: Andreotti F, Ferrante G, Crea F PMID: 20062943 [PubMed - in process] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3167637 Fri, 01 Jan 2010 00:00:00 +0100 3167637 http://www.medworm.com/index.php?rid=3108866&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20024489%26dopt%3DAbstract Authors: Broze Jr GJ, Tu Y PMID: 20024489 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3108866 Fri, 18 Dec 2009 00:00:00 +0100 3108866 http://www.medworm.com/index.php?rid=3108865&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20024490%26dopt%3DAbstract In conclusion, IP attenuates the release of MPO and platelet activation, thereby contributing to the maintenance of vessel patency at microvascular level after reperfusion of the infarct-related artery. PMID: 20024490 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3108865 Fri, 18 Dec 2009 00:00:00 +0100 3108865 http://www.medworm.com/index.php?rid=3108864&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20024491%26dopt%3DAbstract In conclusion, there was a clear effect of rFVIIa on all thromboelastography parameters, but the large intra- and inter-patient variability following in vivo rFVIIa administration renders the use of our method unsuitable for dose-response prediction for haemophilia patients in the clinical setting. PMID: 20024491 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3108864 Fri, 18 Dec 2009 00:00:00 +0100 3108864 http://www.medworm.com/index.php?rid=3108863&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20024492%26dopt%3DAbstract Authors: Freudenberger RS, Schumaecker M, Homma S Many studies suggest a higher incidence of thromboembolic syndromes such as stroke, peripheral arterial thrombosis and pulmonary embolism in patients with heart failure (HF), particularly those with left ventricular systolic dysfunction. As a result, some clinicians have chosen to treat patients with HF with anticoagulants as primary prevention against thromboembolic events. However, this practice is not well-supported by scientific data. Retrospective analyses of large HF trials have yielded contradictory results and randomised trials designed to specifically address this question have been under-populated and under-powered. As a result, there is no general consensus among professional societies in either recommending or advising again... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3108863 Fri, 18 Dec 2009 00:00:00 +0100 3108863 http://www.medworm.com/index.php?rid=3108862&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20024493%26dopt%3DAbstract Authors: Straub A, Smolich J, d'Udekem Y, Brizard C, Peter K, Horton S PMID: 20024493 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3108862 Fri, 18 Dec 2009 00:00:00 +0100 3108862 http://www.medworm.com/index.php?rid=3108861&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20024494%26dopt%3DAbstract Authors: Panzer S, Badr-Eslam R, Schneller A, Kaider A, Koren D, Eichelberger B, Rosenhek R, Budde U, Lang IM Severe aortic stenosis is associated with a haemostatic abnormality that resembles acquired von Willebrand syndrome type 2. It is assumed that high shear conditions render large von Willebrand factor (VWF) multimers accessible to cleavage by ADAMTS-13. However, whether loss of these large multimers affects platelet function by impairing adherence, aggregate formation, or both has not been evaluated in clinical studies. We prospectively enrolled 47 patients with severe aortic stenosis, and studied them prior to aortic valve surgery and at a median of six months after valve replacement. We investigated levels of large VWF multimers, platelet function under high shear conditions, ... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3108861 Fri, 18 Dec 2009 00:00:00 +0100 3108861 http://www.medworm.com/index.php?rid=3108860&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20024495%26dopt%3DAbstract In conclusion, the processes of thrombin generation and fibrin clot formation are independently reduced in acquired dilutional coagulopathy, while minimal levels of both seem to be required for adequate haemostasis. PMID: 20024495 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3108860 Fri, 18 Dec 2009 00:00:00 +0100 3108860 http://www.medworm.com/index.php?rid=3108859&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20024496%26dopt%3DAbstract Authors: Paneesha S, McManus A, Arya R, Scriven N, Farren T, Nokes T, Bacon S, Nieland A, Cooper D, Smith H, O'Shaughnessy D, Rose P Venous thromboembolism (VTE) is a clinically important complication for both hospitalised and ambulatory cancer patients. In the current study, the frequency, demographics and risk (according to tumour site) of VTE were examined among patients seen at outpatient DVT (deep-vein thrombosis) clinics. Of 10,015 VTE cases, 1,361 were diagnosed with cancer, for an overall rate of cancer-associated VTE of 13.6% in this outpatient population. Patients with cancer-associated VTE were significantly older than cancer-free VTE cases (66.4 +/- 12.7 vs. 58.8 +/- 18.5 years; p<0.0001). The frequency of cancer-associated VTE peaked earlier among females than males, oc... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3108859 Fri, 18 Dec 2009 00:00:00 +0100 3108859 http://www.medworm.com/index.php?rid=3108858&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20024497%26dopt%3DAbstract Authors: Tanka-Salamon A, Kolev K, Machovich R, Komorowicz E The formation of platelet-rich thrombi under high shear rates requires both fibrinogen and von Willebrand factor (VWF) as molecular adhesives between platelets. We attempted to describe the role of VWF as a potential substrate and modulator of the fibrinolytic system using binding assays, as well as kinetic measurements on the cleavage of fibrin(ogen) and a synthetic plasmin substrate (Spectrozyme-PL). The similar dissociation constants for the binding of plasminogen, plasmin, and active site-blocked plasmin onto immobilised VWF suggest that the primary binding site in plasmin(ogen) is not the active site. The progressive loss of clottability and generation of degradation products during fibrinogen digestion with plasmin were... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3108858 Fri, 18 Dec 2009 00:00:00 +0100 3108858 http://www.medworm.com/index.php?rid=3108857&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20024498%26dopt%3DAbstract In conclusion, the results show that Pam3CSK4-induced platelet aggregation and secretion depends on a P2X1-mediated Ca2+ mobilisation, production of TxA2 and ADP receptor activation. The findings in this study further support a role for platelets in sensing bacterial components. PMID: 20024498 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3108857 Fri, 18 Dec 2009 00:00:00 +0100 3108857 http://www.medworm.com/index.php?rid=3108856&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20024499%26dopt%3DAbstract Authors: Rose AJ, Ozonoff A, Henault LE, Hylek EM Little is known about patients who receive oral anticoagulation for valvular heart disease (VHD) in community-based practice. It was this study's objective to describe the characteristics, management, and outcomes of patients anticoagulated for VHD, compared to patients anticoagulated for atrial fibrillation (AF). We used a nationally-representative cohort of community-based anticoagulation care in the United States. Data collected included indications for therapy, demographics, selected comorbid conditions, international normalised ratio (INR) target ranges, INR control, and clinical outcomes. We identified 1,057 patients anticoagulated for VHD (15.6% of the overall cohort) and 3,396 patients anticoagulated for AF (50.2%). INR variabil... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3108856 Fri, 18 Dec 2009 00:00:00 +0100 3108856 http://www.medworm.com/index.php?rid=3108855&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20024500%26dopt%3DAbstract Authors: Henry BL, Abdel Aziz M, Zhou Q, Desai UR Recently we prepared sulfated, low-molecular-weight lignins (LMWLs) to mimic the biological activities of heparin and heparan sulfate. Chemo-enzymatically prepared sulfated LMWLs represent a library of diverse non-sugar, aromatic molecules with structures radically different from the heparins, and have been found to potently inhibit thrombin and factor Xa. To assess their effect on the fibrinolytic system, we studied the interaction of LMWLs with human plasmin. Enzyme inhibition studies indicate that the three sulfated LMWLs studied inhibit plasmin with IC50 values in the range of 0.24 and 1.3 mM, which are marginally affected in the presence of antithrombin. Similarly, plasmin degradation of polymeric fibrin is also inhibited by sulfat... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3108855 Fri, 18 Dec 2009 00:00:00 +0100 3108855 http://www.medworm.com/index.php?rid=3108854&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20024501%26dopt%3DAbstract Authors: Wolowacz SE, Roskell NS, Plumb JM, Clemens A, Noack H, Robinson PA, Dolan G, Brenkel IJ Oral dabigatran etexilate is indicated for the prevention of venous thromboembolism (VTE) in patients undergoing total knee replacement or total hip replacement. We investigated the cost-effectiveness of the 150 mg once daily (od) dose recommended for patients aged over 75 or with moderate renal impairment, from a United Kingdom National Health Service perspective. Dabigatran etexilate was compared with subcutaneous enoxaparin 40 mg od, using a decision model. Risks for VTE and bleeding were derived from subgroup analyses of the phase III trials. Dabigatran etexilate was less costly than enoxaparin; cost savings varied from pound62 to pound274 (base-case analyses) and were primarily due to ... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3108854 Fri, 18 Dec 2009 00:00:00 +0100 3108854 http://www.medworm.com/index.php?rid=3108853&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20024502%26dopt%3DAbstract Authors: Yang L, Manithody C, Qureshi SH, Rezaie AR Heparin promotes the antithrombin (AT) inactivation of factors IXa (fIXa) and Xa (fXa) through a conformational activation of the serpin and also by a template mechanism in the presence of physiological levels of Ca2+. Recently, it was reported that heparin induces conformational changes in the active-sites of fIXa and fXa, raising the possibility that heparin also modulates the reactivity of these proteases with AT by this mechanism. To test this possibility, we prepared an AT mutant in which four critical heparin-binding residues of the serpin (Arg-45, Arg-46, Lys-114, and Arg-129) were replaced with non-basic residues. This mutant lost its affinity for heparin, but retained its normal reactivity with coagulation proteases. Thus, th... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3108853 Fri, 18 Dec 2009 00:00:00 +0100 3108853 http://www.medworm.com/index.php?rid=3108852&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20024503%26dopt%3DAbstract Authors: Di Micco P, D'Uva M, Lodigiani C, Rota LL PMID: 20024503 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3108852 Fri, 18 Dec 2009 00:00:00 +0100 3108852 http://www.medworm.com/index.php?rid=3108851&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20024504%26dopt%3DAbstract Authors: Dargaud Y, Hierso S, Rugeri L, Battie C, Gaucherand P, Négrier C, Trzeciak MC PMID: 20024504 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3108851 Fri, 18 Dec 2009 00:00:00 +0100 3108851 http://www.medworm.com/index.php?rid=3108850&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20024505%26dopt%3DAbstract Authors: Serebruany VL Clopidogrel monopoly as an exclusive oral antiplatelet agent used in combination with aspirin or as a monotherapy for treatment or/and prevention of occlusive thrombotic vascular events has been recently challenged. Based on the indirect comparison of TRITON and PLATO trial data, ticagrelor is clearly superior to prasugrel in a population of patients with acute coronary syndrome (ACS) because of absolute mortality reduction, realistic second myocardial infarction (MI) prevention, growing over time vascular outcome benefit, fewer haemorrhagic fatalities, potentially less coronary artery bypass graft (CABG)- related bleeding events, and lack of cancer risks. Despite an unfavourable immediate safety profile, ticagrelor has a lot of room to compensate for agitation, ... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3108850 Fri, 18 Dec 2009 00:00:00 +0100 3108850 http://www.medworm.com/index.php?rid=3108849&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20024506%26dopt%3DAbstract Authors: Warkentin TE, Moore JC PMID: 20024506 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3108849 Fri, 18 Dec 2009 00:00:00 +0100 3108849 http://www.medworm.com/index.php?rid=3108848&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20024507%26dopt%3DAbstract Authors: Drosopoulos JH, Kraemer R, Shen H, Upmacis RK, Marcus AJ, Musi E Blood platelets provide the initial response to vascular endothelial injury, becoming activated as they adhere to the injured site. Activated platelets recruit leukocytes, and initiate proliferation and migration of vascular smooth muscle cells (SMC) within the injured vessel wall, leading to development of neointimal hyperplasia. Endothelial CD39/NTPDase1 and recombinant solCD39 rapidly metabolise nucleotides, including stimulatory ADP released from activated platelets, thereby suppressing additional platelet reactivity. Using a murine model of vascular endothelial injury, we investigated whether circulating human solCD39 could reduce platelet activation and accumulation, thus abating leukocyte infiltration and ... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3108848 Fri, 18 Dec 2009 00:00:00 +0100 3108848 http://www.medworm.com/index.php?rid=3068169&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19967127%26dopt%3DAbstract Authors: Goldhaber SZ PMID: 19967127 [PubMed - in process] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3068169 Tue, 01 Dec 2009 00:00:00 +0100 3068169 http://www.medworm.com/index.php?rid=3068168&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19967128%26dopt%3DAbstract Authors: Behling-Kelly E PMID: 19967128 [PubMed - in process] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3068168 Tue, 01 Dec 2009 00:00:00 +0100 3068168 http://www.medworm.com/index.php?rid=3068167&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19967129%26dopt%3DAbstract Authors: Schnittler H, Preissner KT PMID: 19967129 [PubMed - in process] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3068167 Tue, 01 Dec 2009 00:00:00 +0100 3068167 http://www.medworm.com/index.php?rid=3068166&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19967130%26dopt%3DAbstract This article reviews the current knowledge about natural and experimental infections in different mammals, focusing on the main organ and cell tropism in vivo, and summarises some recent studies in cell culture on the role of ephrin-B2 and -B3 receptors in NiV infection of endothelial cells. PMID: 19967130 [PubMed - in process] (Source: Thrombosis and Haemostasis) Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3068166 Tue, 01 Dec 2009 00:00:00 +0100 3068166 http://www.medworm.com/index.php?rid=3068165&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19967131%26dopt%3DAbstract Authors: Kunz S Viral haemorrhagic fevers (VHF) caused by arenaviruses are among the most devastating emerging human diseases. The most important pathogen among the arenaviruses is Lassa virus (LASV), the causative agent of Lassa fever that is endemic to West Africa. On the South American continent, the New World arenavirus Junin virus (JUNV), Machupo (MACV), Guanarito (GTOV), and Sabia virus (SABV) have emerged as causative agents of severe VHFs. Clinical and experimental studies on arenavirus VHF have revealed a crucial role of the endothelium in their pathogenesis. However, in contrast to other VHFs, haemorrhages are not a salient feature of Lassa fever and fatal cases do not show overt destruction of vascular tissue. The functional alteration of the vascular endothelium that preced... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3068165 Tue, 01 Dec 2009 00:00:00 +0100 3068165 http://www.medworm.com/index.php?rid=3068164&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19967132%26dopt%3DAbstract Authors: Mackow ER, Gavrilovskaya IN Hantaviruses cause two vascular permeability-based diseases and primarily infect endothelial cells which form the primary fluid barrier of the vasculature. Since hantavirus infections are not lytic, the mechanisms by which hantaviruses cause haemorrhagic fever with renal syndrome (HFRS) or Hantavirus Pulmonary Syndrome (HPS) are indeterminate. HPS is associated with acute pulmonary oedema and HFRS with moderate haemorrhage and renal sequelae, perhaps reflecting the location of vast microvascular beds and endothelial cell reservoirs available for hantavirus infection. Endothelial cells regulate capillary integrity, and hantavirus infection provides a primary means for altering vascular permeability that contributes to pathogenesis. The central import... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3068164 Tue, 01 Dec 2009 00:00:00 +0100 3068164 http://www.medworm.com/index.php?rid=3068163&cid=s_33576_19_f&fid=33576&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19967133%26dopt%3DAbstract Authors: Srikiatkhachorn A Dengue viruses (DENV), a group of four serologically distinct but related flaviviruses, are the cause of one of the most important emerging viral diseases. DENV infections result in a wide spectrum of clinical disease including dengue haemorrhagic fever (DHF), a viral haemorrhagic disease characterised by bleeding and plasma leakage. The characteristic feature of DHF is the transient period of plasma leakage and a haemorrhagic tendency. DHF occurs mostly during a secondary DENV infection. Serotype cross-reactive antibodies and mediators from serotype cross-reactive Dengue-specific T cells have been implicated in the pathogenesis. A complex interaction between virus, host immune response and endothelial cells likely impacts the barrier integrity and functions ... Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=3068163 Tue, 01 Dec 2009 00:00:00 +0100 3068163