MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Tissue Antigens' source. Wed, 08 Feb 2012 06:43:03 +0100 http://www.medworm.com/index.php?rid=5666427&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2012.01844.x (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5666427 Wed, 08 Feb 2012 11:13:16 +0100 5666427 http://www.medworm.com/index.php?rid=5666426&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2012.01841.x (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5666426 Wed, 08 Feb 2012 11:13:14 +0100 5666426 http://www.medworm.com/index.php?rid=5666425&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2012.01840.x (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5666425 Wed, 08 Feb 2012 11:13:13 +0100 5666425 http://www.medworm.com/index.php?rid=5666424&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2012.01839.x (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5666424 Wed, 08 Feb 2012 11:13:11 +0100 5666424 http://www.medworm.com/index.php?rid=5666423&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2012.01837.x This study shows that the HLA‐B44‐restricted Rev CD8+ T‐cell epitope EL9 is immunogenic notwithstanding its close resemblance to a human peptide. The epitope mutates as a consequence of dynamic interaction between T‐cells and HIV‐1. Clinical status, CD4+ T‐cell count and viral load remained stable despite escape from T‐cell recognition. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5666423 Wed, 08 Feb 2012 11:12:51 +0100 5666423 http://www.medworm.com/index.php?rid=5666422&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2012.01838.x This study lays the foundations for further disease association analyses. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5666422 Wed, 08 Feb 2012 11:12:48 +0100 5666422 http://www.medworm.com/index.php?rid=5666421&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01831.x The dynamic interaction between the host immune system and growing cancer has been of central interest to the field of tumor immunology over the past years. Recognition of tumor‐associated antigens (TAA) by self‐HLA (human leukocyte antigen) class I‐restricted CD8+ T cells is a main feature in the detection and destruction of malignant cells. The discovery and molecular characterization of TAA has changed the field of cancer treatment and introduced a new era of cancer immunotherapy aimed at increasing tumor immunogenicity and T‐cell‐mediated anti‐tumor immunity. Unfortunately, while these new protocols of cancer immunotherapy are mediating induction of tumor‐specific T lymphocytes in patients with certain malignancies, they have not yet delivered substantial clinical benefit... Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5666421 Wed, 08 Feb 2012 11:12:45 +0100 5666421 http://www.medworm.com/index.php?rid=5646585&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2012.01843.x Polymorphisms in cell surface receptors of natural killer cells and their ligands on target cells can affect susceptibility to viral infections including human immunodeficiency virus (HIV)‐1. We found that the carriage of the human leukocyte antigen (HLA)‐G minus 14‐bp polymorphism, LILRB1 single nucleotide polymorphism rs1061680, and activating and inhibitory killer immunoglobulin‐like receptors (KIRs) were different when data were compared between Caucasian, African Americans and Asian populations. However, carriage was similar when HIV‐1 patients were compared with control donors, with the exception of the African American cohort. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5646585 Thu, 02 Feb 2012 05:00:00 +0100 5646585 http://www.medworm.com/index.php?rid=5646584&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2012.01845.x Follicular lymphoma (FL) is an indolent, sometimes, fatal disease characterized by recurrence at progressively shorter intervals and is frequently refractive to therapy. Genome‐wide association studies have identified single nucleotide polymorphisms (SNPs) in the human leukocyte antigen (HLA) region on chromosome 6p21.32‐33 that are statistically significantly associated with FL risk. Low to medium resolution typing of single or multiple HLA genes has provided an incomplete picture of the total genetic risk imparted by this highly variable region. To gain further insight into the role of HLA alleles in lymphomagenesis and to investigate the independence of validated SNPs and HLA alleles with FL risk, high‐resolution HLA typing was conducted using next‐generation sequencing in 222 n... Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5646584 Wed, 01 Feb 2012 05:00:00 +0100 5646584 http://www.medworm.com/index.php?rid=5637803&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2012.01842.x The Brazilian population represents an admixture of native Amerindians, Portuguese settlers and Africans who were brought as slaves during the colonization period that began in the 16th century and was followed by waves of immigrations of Europeans and Asians in the 20th century. The contribution of these different ethnic groups to the constitution of Brazilian populations from different geographic regions is variable and, in addition to environmental factors, might act by determining different allele profiles among Brazilian populations from different regions. We studied polymorphic sites at the 3′ untranslated region of the HLA‐G gene in individuals from a Northeastern Brazilian region and compared them to our previously published data about a Southeastern Brazilian region, located a... Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5637803 Sun, 29 Jan 2012 11:13:08 +0100 5637803 http://www.medworm.com/index.php?rid=5637804&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2012.01836.x In this study, we reported a new technique in detecting HLA‐B*15:02 by using a nested sequence‐specific primer‐polymerase chain reaction (SSP‐PCR) that can be used on genomic DNA and whole blood for carbamazepine hypersensitivity prediction. We tested a total of 200 blind samples with known human leukocyte antigen (HLA)‐B allelic types (44 positive for HLA‐B*15:02 and 156 negative for HLA‐B*15:02) with this new nested SSP‐PCR technique and compared its efficacy to that of commercial sequence‐specific oligonucleotide probe‐polymerase chain reaction (SSOP‐PCR). Using starting materials from DNA and whole blood, we were able to detect HLA‐B*15:02 in 44 of our samples correctly. The test is very sensitive and is highly reproducible. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5637804 Sat, 28 Jan 2012 05:00:00 +0100 5637804 http://www.medworm.com/index.php?rid=5607637&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01832.x Human leukocyte antigen (HLA)‐E is an inhibitory ligand of natural killer cells and γ/δ T‐cells. Differential expression of HLA‐E alleles on the cell surface has been reported to influence outcome of hematopoietic stem cell transplantation (HSCT). We performed HLA‐E genotyping in 116 HSCT patients and their HLA‐matched unrelated donors. The impact of HLA‐E genotypes on patient's overall survival (OS), disease free survival (DFS), cumulative incidences for relapse, transplant‐related mortality (TRM) and acute graft vs host disease (aGvHD) was assessed. Neither univariate nor multivariate analysis showed any influence of HLA‐E polymorphisms on the investigated endpoints of HSCT in our cohort. We could not confirm any of the previous observations in our cohort and consider i... Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5607637 Fri, 20 Jan 2012 11:13:24 +0100 5607637 http://www.medworm.com/index.php?rid=5607638&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01833.x To determine the complete sequence of a newly identified human leukocyte antigen (HLA)‐C allele, we designed a method where the full genomic sequence of HLA‐C*04 was amplified in isolation from the patient second HLA‐C allele in a single polymerase chain reaction (PCR), using primers spanning its 5′‐ and 3′‐untranslated regions. The new allele, officially designated HLA‐C*04:71, differs from HLA‐C*04:01:01:01 by two single‐nucleotide polymorphisms: one determines substitution of phenylalanine for serine 9 at the B pocket of the peptide‐binding site; the second substitution is a new polymorphism in intron 5. Phe‐9 is characteristic of Cw1 alleles and its presence in C*04:71 most likely affects its peptide‐binding repertoire. The principle we have used for C*04:71 i... Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5607638 Tue, 17 Jan 2012 05:00:00 +0100 5607638 http://www.medworm.com/index.php?rid=5580469&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01835.x rs12979860 in interleukin 28B (IL28B) gene is associated with response to interferon‐α therapy and natural viral clearance in hepatitis C. The role of this polymorphism is less known in hepatitis B virus (HBV) infection. We evaluated whether rs12979860 was associated with outcomes of HBV infection. There were 651 individuals with persistent infection (387 with liver cirrhosis, 264 without cirrhosis) and 226 healthy individuals who recovered from HBV infection. The genotypic distributions were compared between different phenotypes pertaining to disease progression and HBV markers. The polymorphism had no association with clearance of hepatitis B surface antigen and hepatitis B e antigen, HBV‐DNA level, apparent hepatitis onset and liver cirrhosis (P > 0.05). These results suggest th... Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5580469 Fri, 13 Jan 2012 11:12:28 +0100 5580469 http://www.medworm.com/index.php?rid=5666420&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01835.x rs12979860 in interleukin 28B (IL28B) gene is associated with response to interferon‐α therapy and natural viral clearance in hepatitis C. The role of this polymorphism is less known in hepatitis B virus (HBV) infection. We evaluated whether rs12979860 was associated with outcomes of HBV infection. There were 651 individuals with persistent infection (387 with liver cirrhosis, 264 without cirrhosis) and 226 healthy individuals who recovered from HBV infection. The genotypic distributions were compared between different phenotypes pertaining to disease progression and HBV markers. The polymorphism had no association with clearance of hepatitis B surface antigen and hepatitis B e antigen, HBV‐DNA level, apparent hepatitis onset and liver cirrhosis (P > 0.05). These results suggest th... Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5666420 Fri, 13 Jan 2012 05:00:00 +0100 5666420 http://www.medworm.com/index.php?rid=5580470&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01829.x We report here novel Mafa‐A, ‐AG and ‐B alleles identified in two groups of cynomolgus macaques. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5580470 Thu, 12 Jan 2012 05:00:00 +0100 5580470 http://www.medworm.com/index.php?rid=5580472&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01834.x Despite DP antigens have been shown to be stimulators of the mixed lymphocyte reaction, human leukocyte antigen‐DPB1 is not considered in the matching criteria for hematopoietic stem cell transplantation (HSCT). The role of DPB1 matching in HSCT remains inconclusive because of contradictory findings in different studies. The concept of permissible and non‐permissible mismatches might clarify these contradictory results. Although several groups have attempted to identify immunogenic epitopes in exon 2 to establish permissive and non‐permissive allele groups, the direct correlation between individual exon 2 amino acids and epitopes with DPB1 immunogenicity is still not evident. We hypothesize that polymorphism within the entire molecule, including polymorphic variability in different e... Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5580472 Mon, 09 Jan 2012 05:00:00 +0100 5580472 http://www.medworm.com/index.php?rid=5580471&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01823.x A novel HLA‐B*51:01:29 allele differs from B*51:01:01 at one nucleotidic position in the exon 3. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5580471 Mon, 09 Jan 2012 05:00:00 +0100 5580471 http://www.medworm.com/index.php?rid=5571721&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01818.x The relevance of innate immune responses to Plasmodium falciparum infection, in particular the central role of natural killer (NK) cell‐derived interferon gamma (IFN‐γ), is becoming increasingly recognised. Recently, it has been shown that IFN‐γ production in response to P. falciparum antigens is in part regulated by killer‐cell immunoglobulin‐like receptor (KIR) genes, and a study from malaria‐exposed Melanesians suggested an association between KIR genotypes and susceptibility to infection. This prompted us to determine and compare the frequencies of 15 KIR genes in Gambian children presenting with either severe malaria (n = 133) or uncomplicated malaria (n = 188) and in cord‐blood population control samples (n = 314) collected from the same area. While no significant dif... Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5571721 Sun, 08 Jan 2012 11:12:54 +0100 5571721 http://www.medworm.com/index.php?rid=5571720&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01820.x Assessment of the host immune status is becoming a key issue in allogeneic hematopoietic stem cell transplantation (allo‐HSCT). In the long‐term follow‐up of these patients, severe post‐transplant infections, relapse or secondary malignancies may be directly related to persistent immune defects. In allo‐HSCT, T‐cell differentiation of donor progenitors within the recipient thymus is required to generate naive recent T‐cell emigrants (RTE). These cells account for a durable T‐cell reconstitution, generating a diverse T‐cell receptor (TCR) repertoire and robust response to infections. It is now possible to quantify the production of RTE by measuring thymic T‐cell receptor excision circles or ‘TREC’ which are small circular DNA produced during the recombination of the ... Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5571720 Sun, 08 Jan 2012 11:12:48 +0100 5571720 http://www.medworm.com/index.php?rid=5571717&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01830.x Human leukocyte antigen‐G (HLA‐G) is a non‐classical HLA class Ib molecule shown to exhibit immunomodulatory function in a wide range of immune‐based disorders. A number of functional HLA‐G gene polymorphisms have been identified, including a 14‐bp insertion/deletion polymorphism in exon 8 of the 3′ untranslated region of the HLA‐G gene, which has been associated with HLA‐G mRNA stability. Moreover, studies show that homozygosity for the 14‐bp insertion/deletion polymorphism is associated with lower HLA‐G mRNA and protein levels and unique alternative splicing patterns. Here, we introduce a quick and reliable method to screen for the HLA‐G 14‐bp insertion/deletion polymorphism using an optimized real‐time polymerase chain reaction protocol. The genotyping assay ... Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5571717 Sun, 08 Jan 2012 11:12:21 +0100 5571717 http://www.medworm.com/index.php?rid=5571719&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01826.x MICA*064N is similar to MICA*027 except for one nucleotide mutation at position 801(G>A), resulting in a premature stop codon in exon 4. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5571719 Fri, 06 Jan 2012 05:00:00 +0100 5571719 http://www.medworm.com/index.php?rid=5571718&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01827.x (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5571718 Fri, 06 Jan 2012 05:00:00 +0100 5571718 http://www.medworm.com/index.php?rid=5551769&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01828.x In conclusion, the study confirms the association of the IL2RA locus with T1D in the Polish population. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5551769 Fri, 30 Dec 2011 23:45:34 +0100 5551769 http://www.medworm.com/index.php?rid=5551770&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01821.x Tuberculosis (TB) is caused by Mycobacterium tuberculosis and is a major cause of morbidity and mortality worldwide. Many candidate genes have been investigated for a possible association with TB. Toll‐like receptors (TLRs) are known to play important roles in human innate immune systems. Polymorphisms in and functions of TLRs have been investigated to identify associations with specific infectious diseases, including TB. Here, we examined whether single‐nucleotide polymorphisms (SNPs) in TLRs and genes in TLR signaling were associated with TB susceptibility in Indonesian and Vietnamese populations. A statistically significant association was observed between TB susceptibility in a classified Indonesian female group and rs352139, an SNP located in the intron of TLR9, using the genotype... Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5551770 Thu, 29 Dec 2011 05:00:00 +0100 5551770 http://www.medworm.com/index.php?rid=5543800&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01822.x (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5543800 Tue, 27 Dec 2011 23:45:18 +0100 5543800 http://www.medworm.com/index.php?rid=5537229&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01825.x The novel allele A*02:328 showed one nucleotide difference with A*02:06:01 in exon 3 resulting in an amino acid change at codon 120 from Gly to Arg. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5537229 Sat, 24 Dec 2011 23:45:45 +0100 5537229 http://www.medworm.com/index.php?rid=5537231&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01816.x The new allele might have arisen from HLA‐A*66:01 through a point mutation at codon 182.1 (ACG→GCG) resulting in a non‐conservative change from threonine to alanine. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5537231 Thu, 22 Dec 2011 05:00:00 +0100 5537231 http://www.medworm.com/index.php?rid=5537230&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01819.x In this report, we present the full‐length coding sequence of A*31:53, a novel allele with a single‐nucleotide difference in exon 3 with respect to A*31:01:02. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5537230 Thu, 22 Dec 2011 05:00:00 +0100 5537230 http://www.medworm.com/index.php?rid=5523699&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01824.x HLA‐DQB1*05:03:05 differs from DQB1*05:03:01 at nucleotide position 336 A>G in exon 2. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5523699 Wed, 21 Dec 2011 23:45:37 +0100 5523699 http://www.medworm.com/index.php?rid=5514866&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01817.x . (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5514866 Sun, 18 Dec 2011 23:45:16 +0100 5514866 http://www.medworm.com/index.php?rid=5514867&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01815.x Nucleotide sequence of HLA‐DQB1*03:03:04 allele was different from that of HLA‐DQB1*03:03:02 by a single nucleotide substitution at position 603 C>T. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5514867 Fri, 16 Dec 2011 05:00:00 +0100 5514867 http://www.medworm.com/index.php?rid=5494315&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01800.x Major histocompatibility complex (MHC) class I‐related chain A gene (MICA) sequence‐based genotyping (SBT) was attempted on a peripheral blood sample collected from a patient evaluated for hematopoietic stem cell retransplant. The electropherogram pattern of MICA SBT indicated the possibility of carrying more than two MICA alleles. Subsequent cloning and sequencing of the polymerase chain reaction products revealed the presence of three distinct MICA alleles: MICA*008:01/:04 (A5.1), MICA*007:01(A4), and MICA*002:01 (A9) in the genotype of this patient. The origin of the third extra MICA allele could not be determined and would require MICA genotyping information from other family members, which is unavailable. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5494315 Mon, 12 Dec 2011 23:45:39 +0100 5494315 http://www.medworm.com/index.php?rid=5494314&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01810.x Disparity of minor histocompatibility antigens (mHAs) is known to induce graft‐versus‐tumor and graft‐versus‐host disease reactions in stem cell transplantation. Not much information is available on genotypic and phenotypic distributions of the currently identified mHAs, especially in Korean population. Therefore, we report genotype and phenotype frequency analyses of 10 autosomal mHAs in 329 unrelated healthy Koreans using the Sequenom MassARRAY matrix‐assisted laser desorption/ionization time‐of‐flight (MALDI‐TOF) mass spectrometry (MS) system and polymerase chain reaction‐sequence specific primers (PCR‐SSP). Estimates of the probability of immunogenic mismatches between donor/recipient pairs were made from observed phenotypic frequencies. HA‐1 was the most favorabl... Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5494314 Mon, 12 Dec 2011 23:45:34 +0100 5494314 http://www.medworm.com/index.php?rid=5494313&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01809.x Allograft inflammatory factor‐1 (AIF‐1) was originally cloned from a rat heart allograft under chronic rejection. Data from many studies suggested an important role of AIF‐1 in several inflammatory processes. The aim of this study was to examine the dynamic expression of AIF‐1 and its association with the pathogenesis of hepatic schistosomiasis in BALB/c mice infected with S. japonicum. The expression of AIF‐1 and tumour necrosis factor‐alpha (TNF‐α) was determined by enzyme‐linked immunosorbent assay, western blot and immunohistochemistry. AIF‐1 and TNF‐α were overexpressed in hepatic tissues at the early stage of infection, and then diminished with the length of infection. On culturing splenocytes stimulated by soluble egg antigen for 72 h, the expression of AIF‐1... Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5494313 Mon, 12 Dec 2011 23:45:32 +0100 5494313 http://www.medworm.com/index.php?rid=5494312&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01808.x In conclusion, our study suggests that absence of the common haplotype in the TLR10‐TLR1‐TLR6 gene cluster increases the risk of developing chronic disease in patients already affected by sarcoidosis. Based on their role as co‐receptors for TLR‐2, this study supports the growing evidence that aberrant TLR‐2 function is important in sarcoidosis disease pathogenesis. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5494312 Mon, 12 Dec 2011 23:45:30 +0100 5494312 http://www.medworm.com/index.php?rid=5494311&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01799.x Accumulating experimental and clinical evidence has been obtained over recent years in support of the notion that the immune system has the potential to cure cancer. The most convincing example is the graft versus leukaemia effect observed after allogeneic haematopoietic stem cell transplantation. In the autologous setting, however, the isolation and expansion of naturally occurring tumour‐specific T cells is a challenging task. Cancer antigens are often self‐antigens and cancer‐specific T cells are thus subject to selective mechanisms of central and peripheral tolerance. The significant advances in gene‐transfer technologies developed over the last decade have offered new tools to overcome these limitations. Natural T cells can be genetically modified to generate high numbers of �... Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5494311 Mon, 12 Dec 2011 23:45:27 +0100 5494311 http://www.medworm.com/index.php?rid=5494310&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01798.x (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5494310 Mon, 12 Dec 2011 23:45:26 +0100 5494310 http://www.medworm.com/index.php?rid=5486151&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01813.x The sequence of HLA‐B*08:01:08 differs from other HLA‐B*08:01 alleles by at least two synonymous nucleotide exchanges. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5486151 Thu, 01 Dec 2011 05:00:00 +0100 5486151 http://www.medworm.com/index.php?rid=5475882&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01814.x We investigated soluble human leukocyte antigen‐G (sHLA‐G) expression according to the phases of hepatitis B virus (HBV) infections and hepatocellular carcinoma (HCC). A total of 267 sera from anti‐HBs positive healthy individuals (n = 50), chronic HBV carriers (n = 45), as well as patients with active hepatitis B (n = 46), liver cirrhosis (LC, n = 46) and early stage HCC (n = 80) were collected and assayed for sHLA‐G. Relationships between sHLA‐G levels and clinicopathologic parameters including HCC stages, differentiation grades, and levels of aminotransferases, HBV DNA and alpha‐fetoprotein (AFP) were assessed. Concentrations of sHLA‐G were higher in the active hepatitis B and HCC groups (median sHLA‐G 53.7 and 178.8 U/ml, respectively) in comparison to other groups (P &... Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5475882 Thu, 01 Dec 2011 05:00:00 +0100 5475882 http://www.medworm.com/index.php?rid=5468195&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01812.x In this study, the impact of compound KIR/HLA genotype on susceptibility to pulmonary tuberculosis (TB) has been evaluated in Iranian individuals. A total of 107 TB patients and 100 matched healthy controls were genotyped for 17 KIR genes and their three major HLA class I ligand groups (‐C1, ‐C2 and ‐Bw4: ‐B Bw4Ile80, ‐B Bw4Thr80 and ‐A Bw4) by a polymerase chain reaction‐sequence‐specific primers assay. Various analyses including distribution of KIR and HLA ligand genes and genotypes, frequency of inhibitory and activating KIR+HLA combinations and compound genotype status regarding balance of inhibitory and activating components showed no significant difference between patient and control groups. These findings may suggest that compound KIR/HLA genotype has no major impact... Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5468195 Thu, 01 Dec 2011 05:00:00 +0100 5468195 http://www.medworm.com/index.php?rid=5456541&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01806.x The novel B*51:63 is identical to B*51:01:01 with an exception of one base substitution at position 76 (A > C) of exon 3 resulting in codon #116 changed from TAC (Tyr) to TCC (Ser). (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5456541 Wed, 30 Nov 2011 23:45:17 +0100 5456541 http://www.medworm.com/index.php?rid=5449384&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01811.x The aim of this study is to explore human leukocyte antigen (HLA)‐DQ variability in two populations (Cayapas Amerindians and Afro‐Ecuadorians) who live near one another along the Cayapa River and who are exposed to the same environmental stresses, such as infection by Onchocerca volvulus. HLA‐DQA1 and HLA‐DQB1 of 149 unrelated individuals (74 Cayapas and 75 Afro‐Ecuadorians) have been analyzed. HLA high‐resolution molecular typing was performed by sequence‐based typing, sequence‐specific oligonucleotides hybridization and sequence‐specific primer (SSP) amplification. The comparison between affected (cases) and unaffected people (controls) in both populations shows the key role of several HLA‐DQA1 alleles in susceptibility and protection against onchocerciasis. In both p... Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5449384 Sun, 27 Nov 2011 23:45:33 +0100 5449384 http://www.medworm.com/index.php?rid=5440044&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01804.x The MICA*010:02 allele differs from MICA*010:01 allele by a synonymous mutation in exon 5 at position 933(T > C). (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5440044 Thu, 24 Nov 2011 23:45:28 +0100 5440044 http://www.medworm.com/index.php?rid=5440045&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01807.x Optimal methods for using dried blood spots (DBSs) for population genetics‐based studies have not been well established. Using DBS stored for 8 years from 21 pregnant South African women, we evaluated three methods of gDNA extraction with and without whole‐genome amplification (WGA) to characterize immune‐related genes: interleukin‐10 (IL‐10), killer immunoglobulin‐like receptors (KIRs) and human leukocyte antigen (HLA) class I. We found that the QIAamp DNA mini kit yielded the highest gDNA quality (P< 0.05; Wilcoxon signed rank test) with sufficient yield for subsequent analyses. In contrast, we found that WGA was not reliable for sequence‐specific primer polymerase chain reaction (SSP‐PCR) analysis of KIR2DL1, KIR2DS1, KIR2DL5 and KIR2DL3 or high‐resolution HLA genot... Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5440045 Tue, 22 Nov 2011 05:00:00 +0100 5440045 http://www.medworm.com/index.php?rid=5421199&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01805.x We describe four novel HLA alleles, HLA‐B*15:01:18, HLA‐B*44:110, HLA‐C*04:01:22 and HLA‐DQB1*05:14. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5421199 Fri, 18 Nov 2011 23:45:19 +0100 5421199 http://www.medworm.com/index.php?rid=5421200&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01795.x We describe two novel alleles, MICA*058 and MICA* 002:03. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5421200 Wed, 16 Nov 2011 05:00:00 +0100 5421200 http://www.medworm.com/index.php?rid=5406360&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01797.x (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5406360 Wed, 16 Nov 2011 01:22:49 +0100 5406360 http://www.medworm.com/index.php?rid=5406358&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01792.x (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5406358 Wed, 16 Nov 2011 01:22:48 +0100 5406358 http://www.medworm.com/index.php?rid=5406357&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01790.x (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5406357 Wed, 16 Nov 2011 01:22:46 +0100 5406357 http://www.medworm.com/index.php?rid=5406354&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01784.x Doberman hepatitis (DH) is associated with homozygous DLA‐DRB1*00601/DQA1*00401/DQB1*01303 indicating a role for the immune system in the development of the disease. The dog leucocyte antigen (DLA) class II expression is controlled at the transcriptional level with proximal promoters. Differential expression of DLA class II molecules of antigen‐presenting cells is reported to affect susceptibility to or protection from different immune‐mediated diseases. The aim of this study was to evaluate, whether the variation in promoter areas of homozygous DLA‐DRB1*00601/DQA1*00401/DQB1*01303 Dobermans could explain why some dogs become afflicted with DH and others do not. Our findings suggest that promoter variants are not associated as risk modifiers in homozygous DLA‐DRB1*00601/DQA1*0040... Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5406354 Wed, 16 Nov 2011 01:22:24 +0100 5406354 http://www.medworm.com/index.php?rid=5406353&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01783.x This study investigated the association of rs1883832, a functional single‐nucleotide polymorphism in the CD40 gene with susceptibility to sarcoidosis and phenotypes of sarcoidosis. Genotyping of rs1883832 in 175 Japanese patients with sarcoidosis and 150 age‐ and sex‐matched controls revealed no significant difference between the genotypes of the patient and control groups (CC/CT/TT, 32.8/52.0/14.7% in the patients; 37.3/48.0/14.7% in the controls, P = 0.66; allele C, 59.1% in the patients, 61.3% in the controls, P = 0.57). T‐cell and CD4+ cell counts in the bronchoalveolar lavage fluid were significantly higher in the TT genotype group than in the CC and CT genotype group. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5406353 Wed, 16 Nov 2011 01:22:22 +0100 5406353 http://www.medworm.com/index.php?rid=5406352&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01791.x Coeliac disease is a chronic inflammatory condition of the small intestine, triggered by dietary exposure to gluten in genetically susceptible individuals. Risk alleles at HLA‐DQA1 and HLA‐DQB1 are necessary for disease development, but are alone not sufficient for disease onset. We aimed to identify novel loci underlying susceptibility to coeliac disease through the use of extended Finnish and Hungarian families with multiple affected individuals. An initial whole‐genome linkage approach yielded several loci that were followed up further using the Immunochip custom array. Loci with a parametric logarithm of odds (LOD) score of >1.3 were identified at 4q, 6p [human leukocyte antigen (HLA) region], 6q, 7p, 17p, 17q and at 22p. The 4q and 6q loci have been identified previously in c... Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5406352 Wed, 16 Nov 2011 01:22:19 +0100 5406352 http://www.medworm.com/index.php?rid=5406350&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01779.x This study is the first to report HNA gene frequencies in a Turkish population. It showed that there is no difference of HNA genotype in blood donors with Turkish descent in comparison with German blood donors. The alternating transfusion of blood and blood components is no increased risk for developing alloantibodies against HNA antigens. In pregnancy of mixed couples no special screening programs for HNA are necessary. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5406350 Wed, 16 Nov 2011 01:22:15 +0100 5406350 http://www.medworm.com/index.php?rid=5406349&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01796.x Natural killer (NK) cells can kill transformed cells and represent a promising tool for the treatment of cancer. Their function is governed by a balance of stimulatory and inhibitory signals triggered by surface receptors. Advances in NK cell therapy require the development of dependable methods for obtaining an adequate number of effector cells; additional activation or genetic modification may further increase their anticancer capacity. A method for NK cell expansion used in our laboratory relies on a genetically modified form of the K562 myeloid leukemia cell line, engineered to express a membrane‐bound form of interleukin‐15 and the ligand for the costimulatory molecule 4‐1BB (CD137). Expanded NK cells can be transduced with genes encoding chimeric antigen receptors that stimulat... Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5406349 Wed, 16 Nov 2011 01:22:13 +0100 5406349 http://www.medworm.com/index.php?rid=5406343&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01803.x Characterization of the novel HLA alleles A*02:330, A*11:108, B*40:175, and B*40:176 is described. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5406343 Wed, 16 Nov 2011 01:21:33 +0100 5406343 http://www.medworm.com/index.php?rid=5406344&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01802.x HLA‐B*35:167 allele differs from HLA‐B*35:03:01 and HLA‐B*35:70 by an amino acid exchange at position 152. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5406344 Tue, 15 Nov 2011 05:00:00 +0100 5406344 http://www.medworm.com/index.php?rid=5399772&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01787.x The new alleles, HLA‐B*40:125 and HLA‐B*40:129, present a mismatch at codon 103.1 (G → C) and three mismatches at codons 9.1 (C → T), 11.1 (T → G) and 12.1 (G → A). (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5399772 Thu, 03 Nov 2011 04:00:00 +0100 5399772 http://www.medworm.com/index.php?rid=5399771&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01794.x HLA‐A*03:57 has two amino acid exchanges in exon 2 at adjacent positions of the peptide‐binding groove. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5399771 Thu, 03 Nov 2011 04:00:00 +0100 5399771 http://www.medworm.com/index.php?rid=5399770&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01801.x The non‐classical human leukocyte antigen (HLA) class I genes present a very low rate of variation. So far, only 10 HLA‐E alleles encoding three proteins have been described, but only two are frequently found in worldwide populations. Because of its historical background, Brazilians are very suitable for population genetic studies. Therefore, 104 bone marrow donors from Brazil were evaluated for HLA‐E exons 1–4. Seven variation sites were found, including two known single nucleotide polymorphisms (SNPs) at positions +424 and +756 and five new SNPs at positions +170 (intron 1), +1294 (intron 3), +1625, +1645 and +1857 (exon 4). Haplotyping analysis did show eight haplotypes, three of them known as E*01:01:01, E*01:03:01 and E*01:03:02:01 and five HLA‐E new alleles that carry the n... Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5399770 Tue, 01 Nov 2011 04:00:00 +0100 5399770 http://www.medworm.com/index.php?rid=5358532&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01789.x Major histocompatibility complex (MHC) genes have been investigated because of their crucial role in the defense against pathogens and their high degree of polymorphism. We performed a case–control study to assess a genetic association of MHC genes with susceptibility to tuberculosis (TB). The allelic lineages HLA‐A*02 and B*18 were significantly less frequent in TB patients (n = 112, 44.6% women) than in controls (n = 224, 51.5% women): 18.8% vs 26.5%; odds ratio (OR) = 0.64; P = 0.037 and 2.7% vs 6.9%; OR = 0.37; P = 0.041. The negative association with haplotype HLA‐B*18‐MICA*018 (2.3% patients vs 6.4% controls; OR = 0.34; P = 0.035) was significant as a consequence of strong linkage disequilibrium (D′ = 0.827 for patients and 0.923 for controls). These findings suggest a tren... Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5358532 Sun, 30 Oct 2011 22:45:01 +0100 5358532 http://www.medworm.com/index.php?rid=5399775&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01778.x The novel allele HLA‐C*16:07:02 differs from HLA‐C* 16:07:01 by a silent nucleotide substitution at codon 220 (TAC → TAT). (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5399775 Sun, 30 Oct 2011 04:00:00 +0100 5399775 http://www.medworm.com/index.php?rid=5399774&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01782.x A novel HLA allele, HLA‐A*30:36, is found in a donor from the Central German Bone Marrow Donor Registry. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5399774 Sun, 30 Oct 2011 04:00:00 +0100 5399774 http://www.medworm.com/index.php?rid=5399773&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01793.x The new allele, HLA‐A*33:25, differs from A*33:03:01 by one nucleotide substitution in exon 4 (c.778G>A) which results in an amino acid change at codon 236 [GCA→ACA (Ala>Thr)] in β2‐microglobulin‐binding domain. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5399773 Sun, 30 Oct 2011 04:00:00 +0100 5399773 http://www.medworm.com/index.php?rid=5334713&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01786.x Sequencing of HLA‐C*07:55N assessed the presence of a premature TAG stop codon at residue 113. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5334713 Fri, 21 Oct 2011 22:44:53 +0100 5334713 http://www.medworm.com/index.php?rid=5334714&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01785.x The HLA‐A*02:305N new allele lacks a nucleotide in exon 4 compared to HLA‐A*02:01:01 allele. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5334714 Wed, 19 Oct 2011 04:00:00 +0100 5334714 http://www.medworm.com/index.php?rid=5313599&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01788.x Seventy‐two novel human leukocyte antigen (HLA) class I and class II alleles are described from volunteers for the ‘Be The Match Registry®’: 17 HLA‐A alleles, 12 HLA‐C alleles, 31 HLA‐B alleles and 12 HLA‐DRB1 alleles. Forty‐six (∼64%) of the 72 novel alleles are single‐nucleotide substitution variants when compared with their most homologous allele. Five of these single‐nucleotide variants are silent substitutions and one creates a non‐expressed allele (B*44:108N). The remaining novel alleles differ from their most similar allele by two to five nucleotide substitutions. One of the novel HLA‐C alleles (C*07:150Q) is of questionable expression due to an insertion of 21 nucleotides starting at codon 143 that adds seven amino acids to exon 3. An inter‐locus gene c... Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5313599 Fri, 14 Oct 2011 22:45:22 +0100 5313599 http://www.medworm.com/index.php?rid=5303793&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01776.x We investigated structurally polymorphic Alu insertions (POALINs) at five loci in the major histocompatibility complex (MHC) class I genomic region to determine their allele and haplotype frequencies and associations with the human leukocyte antigen (HLA)‐A, ‐B, and ‐C genes in three populations, the Australian Caucasians, Japanese, and African Americans. The POALINs varied in allelic frequency between 0% and 42.3% with significant differences between populations at three of the five loci. The linkage disequilibrium (LD) between Alu insertions and the HLA‐A, ‐B, or ‐C alleles and previously published polymorphic retroelements (four SVA and human endogenous retrovirus type 9 (HERVK9) loci) within the class I region of the MHC were calculated in pairwise analyses of haplotypes to... Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5303793 Tue, 11 Oct 2011 22:47:11 +0100 5303793 http://www.medworm.com/index.php?rid=5303792&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01775.x In conclusion, it could be suggested that IL‐15 genetic variants can affect resistance or susceptibility to human brucellosis among Iranian patients. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5303792 Tue, 11 Oct 2011 22:47:09 +0100 5303792 http://www.medworm.com/index.php?rid=5303790&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01772.x The aim of this study was to test the hypothesis that closely related human leukocyte antigen (HLA) haplotypes containing the DRB1*07:01 gene [‘DR7’ (DRB1*07:01‐DQA1*02:01‐DQB1*02:01g or DRB1*07:01‐DQA1*03:01‐DQB1*02:01g) haplotypes] derived from European and African populations differ in their genetic susceptibility for type 1 diabetes (T1D) depending on the DQ‐α molecule present. A combined total of 98 African American T1D patients from the Type 1 Diabetes Genetics Consortium and from Children's Hospital and Research Center Oakland were genotyped for the HLA class II loci DRB1, DQA1, and DQB1. DNA samples extracted from newborn blood spot cards from African Americans born in California (n = 947) were used as a population‐based control group. Among African American cases,... Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5303790 Tue, 11 Oct 2011 22:47:07 +0100 5303790 http://www.medworm.com/index.php?rid=5303789&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01777.x Modern high‐throughput HLA and KIR typing technologies are generating a wealth of immunogenomic data with the potential to revolutionize the fields of histocompatibility and immune‐related disease association and population genetic research, much as SNP‐based approaches have revolutionized association research. The STrengthening the REporting of Genetic Association studies (STREGA) statement provides community‐based data reporting and analysis standards for genomic disease‐association studies, identifying specific areas in which adoption of reporting guidelines can improve the consistent interpretation of genetic studies. While aspects of STREGA can be applied to immunogenomic studies, HLA and KIR research requires additional consideration, as the high levels of polymorphism asso... Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5303789 Tue, 11 Oct 2011 22:47:04 +0100 5303789 http://www.medworm.com/index.php?rid=5303788&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01780.x The human P2X7 receptor is a two‐transmembrane ionotropic receptor which has a ubiquitous distribution and is most highly expressed on immune cells. In macrophages and similar myeloid cells primed by lipopolysaccharide (LPS), activation of P2X7 by extracellular ATP opens a cation channel/pore allowing massive K+ efflux associated with processing and secretion of pro‐inflammatory cytokines interleukin (IL)‐1β and IL‐18. A variety of other downstream effects follows P2X7 activation over several minutes including shedding of certain surface molecules, membrane blebbing, microvesicle/exosome release and apoptosis of the cell. High concentrations of ATP (>100 µM) are required to activate P2X7 but it remains unclear where these levels exist, other than in inflammatory foci or confin... Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5303788 Tue, 11 Oct 2011 22:47:02 +0100 5303788 http://www.medworm.com/index.php?rid=5303783&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01774.x In conclusion, our results do not confirm an association of IL6R rs2228145 and IL6ST/gp130 rs2228044 polymorphisms with CV disease in RA. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5303783 Tue, 11 Oct 2011 22:46:17 +0100 5303783 http://www.medworm.com/index.php?rid=5284667&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01773.x HLA‐DRB3*02:27 was detected following investigations into an unusual haplotype, and differs to DRB3*02:02:01 at codons 73–77. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5284667 Mon, 03 Oct 2011 04:00:00 +0100 5284667 http://www.medworm.com/index.php?rid=5284665&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01781.x Neuroblastoma is the most common solid tumor in children less than 5 years of age. The early onset of neuroblastoma suggests that genes involved in fetal development and pregnancy may have a putative role in the etiology of neuroblastoma. The human leukocyte antigen subtype G (HLA‐G) molecule plays an important role in immune response regulation and appears to regulate immune tolerance during early pregnancy as well as tumor immunosurveillance. Elevated levels of soluble HLA‐G (sHLA‐G) have been detected in a number of malignancies including serum samples from neuroblastoma and have been reported to be predictive of tumor relapse in neuroblastoma. In light of previous investigations suggesting that single nucleotide polymorphisms in the HLA‐G gene may impact on protein expression l... Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5284665 Sat, 01 Oct 2011 04:00:00 +0100 5284665 http://www.medworm.com/index.php?rid=5249939&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01760.x (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5249939 Sun, 25 Sep 2011 06:49:45 +0100 5249939 http://www.medworm.com/index.php?rid=5249938&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01759.x (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5249938 Sun, 25 Sep 2011 06:49:43 +0100 5249938 http://www.medworm.com/index.php?rid=5249937&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01758.x (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5249937 Sun, 25 Sep 2011 06:49:42 +0100 5249937 http://www.medworm.com/index.php?rid=5249936&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01768.x Tripartite motif 5α (TRIM5α) is a potent antiretroviral immune factor present in the cytoplasm of cells of most tissue types. The rhesus macaque TRIM5 gene has been shown to display polymorphism, with different variants being divided into three groups (TRIM5TFP, TRIM5Q, and TRIM5CypA), which may have divergent retroviral effects on infection. Along with rhesus macaques, cynomolgus macaques are also used in simian immunodeficiency virus (SIV) infection studies. As a consequence, TRIM5 genotyping of these animals will contribute to interpreting the outcome of such studies. The present communication covers Burmese, Chinese, and a large cohort of Indian‐origin rhesus macaques, and describes the first large cohort study on TRIM5 polymorphism in outbred cynomolgus macaques. We demonstrate th... Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5249936 Sun, 25 Sep 2011 06:49:16 +0100 5249936 http://www.medworm.com/index.php?rid=5249935&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01766.x The frequencies of human leukocyte antigen (HLA) class I and class II specificities and haplotypic associations were determined in 1940 unrelated donors from Castilla y León and compared with other Iberian, Mediterranean and European populations. Specificities were determined using polymerase chain reaction reverse sequence‐specific oligonucleotide or polymerase chain reaction sequence‐specific primer techniques. In the analysis, 19, 29 and 13 specificities were found for HLA‐A, ‐B and ‐DRB1, respectively, with HLA‐A*02 (26%), ‐A*01 (11%), ‐B*44 (16%), ‐B*35 (10%), ‐DRB1*07 (16%) and ‐DRB1*13 (14%) showing the highest frequencies. In addition, 10 common HLA‐A‐B‐DRB1 haplotypic associations were observed, A*01‐B*08‐DRB1*03 (3%) and A*29‐B*44‐DRB1*07 (3%)... Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5249935 Sun, 25 Sep 2011 06:49:14 +0100 5249935 http://www.medworm.com/index.php?rid=5249934&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01757.x In conclusion, we show that parous women non‐immunized are at low risk of HLA Ab production after transplantation. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5249934 Sun, 25 Sep 2011 06:49:12 +0100 5249934 http://www.medworm.com/index.php?rid=5249933&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01770.x As the immunobiological function of the HLA (human leucocyte antigen) class I and II molecules was revealed, we have seen an explosive development of the HLA field. Today, the HLA complex occupies a central position in basic and clinical immunology. In this Opinion article, I will briefly discuss some challenges which in my opinion are more important than others in the near future of HLA, with a focus on products of the classical HLA class I and II genes. Matching for HLA antigens will continue to be of importance in organ and hematopoietic stem cell transplantations. In the latter field, induction of graft‐versus‐leukemia effects will receive greater attention, where HLA will play a central role. It is anticipated that we will see an extensive development in our knowledge of the etiol... Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5249933 Sun, 25 Sep 2011 06:49:11 +0100 5249933 http://www.medworm.com/index.php?rid=5249932&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01771.x In this report, we describe the identification of the novel HLA‐DRB1*13:120 that differs from the closest matching allele HLA‐DRB1*13:65 at two nucleotidic position in the exon 2. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5249932 Sun, 25 Sep 2011 06:48:13 +0100 5249932 http://www.medworm.com/index.php?rid=5224011&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01769.x A*03:132 differs from A*03:01:01:01 at nucleotide 853 (codon 261) in exon 4. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5224011 Thu, 01 Sep 2011 04:00:00 +0100 5224011 http://www.medworm.com/index.php?rid=5207254&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01767.x We report a novel HLA‐B*13 allele, B*13:50, found using high‐resolution sequence‐based typing in a Chinese donor. B*13:50 differs from B*13:01:01 by a single‐nucleotide substitution (A→T) at position 482, in exon 3. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5207254 Thu, 01 Sep 2011 04:00:00 +0100 5207254 http://www.medworm.com/index.php?rid=5160553&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01764.x (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5160553 Sat, 27 Aug 2011 12:09:07 +0100 5160553 http://www.medworm.com/index.php?rid=5160558&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01752.x Two novel HLA‐A alleles differing from their closest related alleles by nucleotide exchanges in introns, A*29:02:01:02 and A*68:01:01:02, were identified. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5160558 Sat, 20 Aug 2011 23:00:00 +0100 5160558 http://www.medworm.com/index.php?rid=5160557&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01761.x The HLA‐B*40:74 allele has two nucleotide changes at positions 103 and 106 of exon 2 from the closest matching allele HLA‐B*40:01:01. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5160557 Sat, 20 Aug 2011 23:00:00 +0100 5160557 http://www.medworm.com/index.php?rid=5160556&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01762.x The new HLA‐B*15:220 allele shows a single‐nucleotide substitution in exon 1 at position 47 (C>T) when compared to its closest allele HLA‐B*15:03:01, resulting in an amino acid substitution from Ala to Val in the signal peptide at codon −9. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5160556 Sat, 20 Aug 2011 23:00:00 +0100 5160556 http://www.medworm.com/index.php?rid=5160555&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01763.x The new HLA‐A*23:38N allele shows a single‐base deletion in exon 2, resulting in a frame shift and a premature stop codon. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5160555 Sat, 20 Aug 2011 23:00:00 +0100 5160555 http://www.medworm.com/index.php?rid=5160554&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01756.x The full‐length sequences of exons 1–8 of this novel HLA‐A*02:230 allele are identical to those of HLA‐A*02:03:01, except for one nucleotide change at nt 858 in exon 3 from G to A. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5160554 Sat, 20 Aug 2011 23:00:00 +0100 5160554 http://www.medworm.com/index.php?rid=5096021&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01747.x (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5096021 Fri, 05 Aug 2011 15:21:04 +0100 5096021 http://www.medworm.com/index.php?rid=5096010&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01749.x We describe the use of real‐time polymerase chain reaction (PCR) assays that allow easy and quick detection of 16 KIR genes and the presence/absence of KIR‐ligands based on allelic discrimination at codon 80 in the HLA‐A/B Bw4 and HLA‐C C1/C2 genes. These methods overcome the tedious and expensive nature of conventional KIR genotyping and HLA class I typing using sequence‐specific primer (SSP) PCR, sequence‐specific oligonucleotide (SSO) hybridization or sequence‐based typing (SBT). Using these two cost‐effective assays, we measured the frequencies of KIRs, KIR‐ligands and KIR/KIR‐ligand pairs in a cohort of Black women recruited in South Africa. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5096010 Fri, 05 Aug 2011 15:20:17 +0100 5096010 http://www.medworm.com/index.php?rid=5096007&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01748.x To assess the potential contribution of major histocompatibility complex class I chain‐related gene A (MICA) polymorphisms toward the pathogenesis of leukemia, 107 leukemia patients and 162 ethnically matched controls from Hunan province, Southern China, were genotyped for the MICA polymorphism using polymerase chain reaction‐sequence‐specific priming (PCR‐SSP) and sequence‐based typing (PCR‐SBT). The relevance between these genotypes and risk of leukemia was assessed by means of odds ratio (OR) with 95% confidence intervals (95% CIs). Allele frequencies of MICA‐sequence and MICA‐STR were different in leukemia patients in comparison with normal controls (both P < 0.05). MICA A5 was directly associated with leukemia (OR = 2.3257, Pc < 0.0005), whereas MICA A5.1 and MIC... Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5096007 Fri, 05 Aug 2011 15:20:10 +0100 5096007 http://www.medworm.com/index.php?rid=5095987&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01755.x Keloid disease (KD) is a common abnormal cutaneous fibrotic disorder of unknown aetiopathogenesis. KD is reported to have a strong genetic component as it is often familial and has a high incidence in certain ethnicities, in particular those of Afro‐Caribbean origin. Genetic risk factors combined with aberrant lesional inflammatory responses point to the human leukocyte antigen (HLA) system as a viable target for investigating disease aetiology. Sequence specific primer polymerase chain reaction with allele sequencing was used to determine HLA‐DQA1 and DQB1 allele frequencies (AF) for 165 KD patients and 119 healthy controls of black Jamaican Afro‐Caribbean origin. HLA class I alleles A*01, A*03, A*25, B*07 and Cw*08:02, previously identified as KD associated in a different ethnicity... Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5095987 Fri, 05 Aug 2011 15:18:21 +0100 5095987 http://www.medworm.com/index.php?rid=5095994&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01742.x A single nucleotide deletion in codon 12 of the human leukocyte antigen HLA‐DRB1*01 results in a novel null allele, DRB1*01:33N. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5095994 Tue, 02 Aug 2011 23:00:00 +0100 5095994 http://www.medworm.com/index.php?rid=5095992&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01743.x We investigated the association of equine arteritis virus (EAV) infection and three short tandem repeat (STR) polymorphisms located within or in close proximity to equine lymphocyte antigen (ELA) region. We used a case–control design as a first approach before proceeding to select candidate genes. One hundred and sixty‐five Silla Argentino horses were taken in 2002 from positive serological detections of EAV in Argentina, to determine whether STR genotypes were correlated to genetic susceptibility to EVA. Allele frequency distribution did not show significant differences between both groups (P = 0.0781). However, in particular alleles, Fisher exact test and odds ratio calculations showed significant values >1 for TKY08 and LEX52, and <1 for UM011, TKY08, LEX52 and VHL20. Interest... Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5095992 Tue, 02 Aug 2011 23:00:00 +0100 5095992 http://www.medworm.com/index.php?rid=5095989&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01754.x Inconsistent reports of associations between human leukocyte antigen (HLA)‐DR and thyroid cancers exist. We conducted a comprehensive search of the PubMed, Scopus and Web of Science databases. Using random‐effects modeling, subgroup analyses, meta‐regression and prediction interval (PI) estimation, we combined the existing evidence from 13 studies (977 cases of thyroid cancer and 3735 controls). Only HLA‐DR1 and HLA‐DR11 were significantly associated; however, the evidence for HLA‐DR11 came from only three studies while that for HLA‐DR1 had large between‐study heterogeneity. All the PIs estimated in the study straddled unity. Therefore, current evidence for the studied association is incomplete as well as uncertain. Attempts to include HLA‐DR typing as a prognostic or the... Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5095989 Tue, 02 Aug 2011 23:00:00 +0100 5095989 http://www.medworm.com/index.php?rid=5086703&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01753.x B*15:228 differs from B*15:01:01:01 at three nucleotides in exon 4. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5086703 Sun, 31 Jul 2011 23:00:00 +0100 5086703 http://www.medworm.com/index.php?rid=5086705&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01750.x In this report we describe a novel allele B*44:127, which was identified in a Chinese voluntary bone marrow donor by sequence‐based typing. HLA‐B*44:127 showed one nucleotide difference from G to A with HLA‐B*44:02:01 at nucleotide 320. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5086705 Sat, 30 Jul 2011 23:00:00 +0100 5086705 http://www.medworm.com/index.php?rid=5086704&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01751.x The novel HLA‐C allele C*06:58 shows one nucleotide change from C*06:02:01:01 at nt 366 from G to A, resulting in an amino acid change at codon 98 of exon 3 from Met to Ile. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5086704 Sat, 30 Jul 2011 23:00:00 +0100 5086704 http://www.medworm.com/index.php?rid=5069357&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01741.x The new allele is identical to A*29:01:01:01 in exons 2 and 3, except for a single‐nucleotide substitution (TTG to TGG) at codon 156. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5069357 Wed, 27 Jul 2011 21:02:55 +0100 5069357 http://www.medworm.com/index.php?rid=5063017&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01744.x The allele was identified in a Chinese individual by sequence‐based typing. HLA‐B*40:162 differs from B*40: 06:01 by a single nucleotide at position 272 C→T in exon 2. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5063017 Tue, 26 Jul 2011 13:54:41 +0100 5063017 http://www.medworm.com/index.php?rid=5052050&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01745.x In this study we sequenced the bound peptides from three alleles belonging to the HLA‐A*74 group (HLA‐A*74:04, A*74:06 and A*74:07) that are distinguished by four polymorphic residues within the peptide‐binding region. Our data illustrates that A*74:04 exhibits preference for L, M or I at P2 and L, S or P at PΩ, while for A*74:07 the P2 anchor prefers L, P or I and the PΩ anchor S, P, L. In contrast A*74:06 features a P2 anchor motif of S or L, while a PΩ anchor could not be defined; however, a preference for polar residues S, T, Q or the charged residue R at the PΩ position could be detected. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5052050 Sat, 23 Jul 2011 13:54:43 +0100 5052050 http://www.medworm.com/index.php?rid=5052055&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01738.x Nucleotide sequence of HLA‐C*07:02:25 allele was different from that of HLA‐C*07:02:01:01 by a single nucleotide substitution at position 78C>G. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5052055 Sun, 17 Jul 2011 23:00:00 +0100 5052055 http://www.medworm.com/index.php?rid=5052054&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01739.x Nucleotide sequence of HLA‐DRB1*12:27 allele was different from that of HLA‐DRB1*12:02:01 by three‐nucleotide substitution at position 165A>C, 171G>C, and 175C>T. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5052054 Sun, 17 Jul 2011 23:00:00 +0100 5052054 http://www.medworm.com/index.php?rid=5052053&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01746.x The new allele HLA‐B*52:23 differs from B*52:01:01 at position 208 in exon 2. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5052053 Sun, 17 Jul 2011 23:00:00 +0100 5052053 http://www.medworm.com/index.php?rid=5052052&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01737.x We present a novel assay capable of resolving heterozygous HLA‐DQB1 allelotypes at two digits, with even greater specificity for the HLA‐DQB1*06 allele family, by using the multiplexed ligation‐dependent probe amplification technology. This assay provides more specific allele data than genome‐wide analysis and is more affordable than sequencing, making it a useful intermediate for researchers seeking to accurately allelotype human DNA samples. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5052052 Sun, 17 Jul 2011 23:00:00 +0100 5052052 http://www.medworm.com/index.php?rid=5052051&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01740.x DRB1*04:98 shows four nucleotide changes regarding DRB1*04:01:01, resulting in two amino acids replacement at positions A73G and A74R. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5052051 Sun, 17 Jul 2011 23:00:00 +0100 5052051 http://www.medworm.com/index.php?rid=5019709&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01730.x HLA‐C*08:43 differs from HLA‐C*08:02:01 by one nucleotide (A>G) at position 584 resulting in an amino acid change of 171 tyrosine to 171 cysteine. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5019709 Wed, 13 Jul 2011 13:54:24 +0100 5019709 http://www.medworm.com/index.php?rid=5009220&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01735.x Major histocompatibility complex (MHC) class I molecules provide the molecular basis for the comprehensive surveillance of an organism by the cytotoxic arm of the adaptive immune system. To exert this function correctly, class I molecules must be loaded with peptide ligands of appropriate length, sequence and affinity that provide a rapidly updated and sufficiently comprehensive picture of the state of the cell. This is accomplished by a sophisticated cellular machinery using a blend of cellular house‐keeping proteins and dedicated transporters, chaperones and peptidases. The last 10 years have seen substantial progress in our comprehension of this machinery. It seems now clear that a large proportion of MHC class I ligands are derived from short‐lived products of the ribosomal apparat... Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5009220 Sat, 09 Jul 2011 13:54:55 +0100 5009220 http://www.medworm.com/index.php?rid=5009225&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01717.x The new allele HLA‐B*15:220 is associated with a conserved haplotype. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5009225 Wed, 06 Jul 2011 23:00:00 +0100 5009225 http://www.medworm.com/index.php?rid=5009224&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01731.x Two hundred and thirty‐six novel human leukocyte antigen (HLA) alleles are described from volunteer donors of the China Marrow Donor Program: 71 HLA‐A alleles, 79 HLA‐B alleles, 43 HLA‐C, 16 HLA‐DRB1 alleles, 26 HLA‐DQB1 and 1 HLA‐DPB1. Two hundred and thirteen (90.3%) of the 236 novel alleles are single nucleotide substitution variants when compared with their most homologous allele. Seventy‐eight of these single nucleotide variants are silent substitutions. The remaining novel alleles differ from their most similar allele by two to four nucleotide substitutions. Some of the novel alleles encode amino acid changes at positions not previously reported to be polymorphic, such as codons 57, 62, 67, 41 and 52 in HLA‐A alleles; codons 133, 156, 201 and 215 in HLA‐B alleles;... Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5009224 Wed, 06 Jul 2011 23:00:00 +0100 5009224 http://www.medworm.com/index.php?rid=5009223&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01681.x Eight novel alleles, two HLA‐A and six HLA‐B, are described in Kazakh individuals. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5009223 Wed, 06 Jul 2011 23:00:00 +0100 5009223 http://www.medworm.com/index.php?rid=5009222&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01734.x In conclusion, IL21 has not been shown to be a major risk gene for MS. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5009222 Wed, 06 Jul 2011 23:00:00 +0100 5009222 http://www.medworm.com/index.php?rid=5009221&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01736.x We report here a high‐throughput, accurate and robust multiplex luminex bead assay for routine clinical testing of C282Y, H63D and S65C mutations in the HFE gene. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5009221 Wed, 06 Jul 2011 23:00:00 +0100 5009221 http://www.medworm.com/index.php?rid=4998210&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01663.x The HLA‐DRB1*15:02:08 allele differs from the closest allele HLA‐DRB1*15:02:01 by a single synonymous nucleotide change at position 116 in exon 2 from C to T. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=4998210 Tue, 05 Jul 2011 13:57:18 +0100 4998210 http://www.medworm.com/index.php?rid=4998209&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01721.x The aim of this study was to analyze the association between gene polymorphisms of killer‐cell immunoglobulin‐like receptors (KIRs) and their human leukocyte antigen (HLA) ligands and susceptibility to B‐cell chronic lymphocytic leukemia (B‐CLL) and the clinical course of disease. The distribution of individual KIR genes in 197 B‐CLL patients and 200 controls was similar, except for a tendency for lower frequencies of the KIR2DS3 and KIR2DL5 genes among B‐CLL patients (26.9% vs 35.5%, P = 0.06, 46.2% vs 55.5%, P = 0.06). The associations between KIR2DS3 and B‐CLL reached statistical significance in women (P = 0.05). Moreover, we found a trend toward a lower frequency of genotypes with the presence of five or six activating KIR genes in B‐CLL patients compared to controls (2... Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=4998209 Tue, 05 Jul 2011 13:57:10 +0100 4998209 http://www.medworm.com/index.php?rid=4998208&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01716.x Human leukocyte antigen‐G (HLA‐G) is a novel tumor marker and its soluble isoforms produce secretory proteins. Increased soluble HLA‐G (sHLA‐G) levels have been reported in patients with melanoma, neuroblastoma, lymphoproliferative disorders, breast, ovarian and colorectal carcinoma when compared to healthy controls or subjects with benign neoplasms. The aim of this study is to investigate whether or not plasma sHLA‐G can be used as a potential biomarker for cancer diagnosis. We measured plasma sHLA‐G levels in 166 patients with early stages of colorectal cancer (CRC, n = 37), gastric cancer (GC, n = 28), esophageal squamous cell carcinoma (ESCC, n = 58) and non‐small cell lung cancer (NSCLC, n = 43), and compared them to healthy controls (n = 260) by using a specific HLA‐G... Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=4998208 Tue, 05 Jul 2011 13:57:09 +0100 4998208 http://www.medworm.com/index.php?rid=4998207&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01714.x NK cells are important contributors to the early immune defence against infected or transformed cells. They are rapidly activated in response to cytokines, whereby they exert their effector functions. NK cell responses are controlled by a multitude of receptors, which are expressed by subpopulations of NK cells with distinct phenotypes and functionalities. Direct comparisons between species are often difficult because of differences in the expression of NK cell receptors and other markers. In addition, NK cells change their phenotype and effector functions during differentiation, by tissue‐specific factors, or upon activation, complicating interpretations. We will here review the similarities and differences between the major NK cell subsets in man and two well‐characterized rodent mod... Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=4998207 Tue, 05 Jul 2011 13:57:05 +0100 4998207 http://www.medworm.com/index.php?rid=5009227&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01722.x The novel allele HLA‐A*68:66 differs from HLA‐A*68:01: 01:01 by a synonymous single nucleotide exchange at position 102 (C→T) and three non‐synonymous exchanges at position 257 (G→A), position 259 (A→G) and position 261 (C→G) in exon 2. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5009227 Mon, 04 Jul 2011 23:00:00 +0100 5009227 http://www.medworm.com/index.php?rid=5009226&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01728.x Twenty‐one novel human leukocyte antigen (HLA) class I and class II alleles are described: seven HLA‐A alleles, five HLA‐C alleles, five HLA‐B alleles and four HLA‐DRB1 alleles. Seventeen (∼81%) of the 21 novel alleles are single nucleotide substitution variants when compared with their most homologous allele. Nine of these single nucleotide variants cause an amino acid substitution, while eight are silent substitutions. The remaining novel alleles differ from their most similar allele by two to three nucleotide substitutions. One novel HLA‐C locus allele encodes an amino acid change at codon 10 that previously has not been reported to be polymorphic for this locus. Some of the new alleles encode novel codons and unique amino acid changes at polymorphic positions in the HLA�... Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=5009226 Mon, 04 Jul 2011 23:00:00 +0100 5009226 http://www.medworm.com/index.php?rid=4969522&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01733.x We report HLA‐C*02:02:09 as a novel allele with a transition C‐>T at position 354. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=4969522 Mon, 27 Jun 2011 15:47:43 +0100 4969522 http://www.medworm.com/index.php?rid=4969530&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01720.x The new DQB1*03:02:05 differs from DQB1*03:02:01 by two nucleotide exchanges in exon 2. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=4969530 Sun, 26 Jun 2011 23:00:00 +0100 4969530 http://www.medworm.com/index.php?rid=4969529&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01723.x The novel HLA‐B*44:130 allele was found in a Spanish donor. B*44:130 differs from B*44:40 by four nucleotide changes at codons 11, 12 and 24, producing three amino acid replacements, 11A>S, 12M>V and 24T>S. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=4969529 Sun, 26 Jun 2011 23:00:00 +0100 4969529 http://www.medworm.com/index.php?rid=4969528&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01724.x The genomic full‐length sequences of C*04:03 and C*04:06 were first identified by cloning and sequencing. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=4969528 Sun, 26 Jun 2011 23:00:00 +0100 4969528 http://www.medworm.com/index.php?rid=4969527&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01725.x Nucleotide sequence of HLA‐B*13:41 allele was different from that of B*13:02:01 at position 538 C>T and 539 T>G, resulting in an amino acid from Leu to Trp at codon 156. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=4969527 Sun, 26 Jun 2011 23:00:00 +0100 4969527 http://www.medworm.com/index.php?rid=4969526&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01726.x The new allele B*35:01:25 showed a single nucleotide substitution compared with B*35:01:01 at codon 238 (GAT/GAC). (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=4969526 Sun, 26 Jun 2011 23:00:00 +0100 4969526 http://www.medworm.com/index.php?rid=4969525&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01727.x A new allele HLA‐B*48:01:03 showed one nucleotide difference with B*48:01:01 at codon 269 (CCC‐>CCT). (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=4969525 Sun, 26 Jun 2011 23:00:00 +0100 4969525 http://www.medworm.com/index.php?rid=4969524&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01729.x The novel HLA‐DQB1*06:43 allele differs from HLA‐DQB1*06:01:01 in one nucleotide substitution at codon 73 in exon 2. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=4969524 Sun, 26 Jun 2011 23:00:00 +0100 4969524 http://www.medworm.com/index.php?rid=4969523&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01732.x We report the new HLA‐DRB1*14:99 allele differing from DRB1*14:01:01 by one nucleotide in exon 2. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=4969523 Sun, 26 Jun 2011 23:00:00 +0100 4969523 http://www.medworm.com/index.php?rid=4969533&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01718.x The new HLA‐C*07:108 differs from C*07:01:01 by two transversions in exon 3. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=4969533 Sat, 25 Jun 2011 23:00:00 +0100 4969533 http://www.medworm.com/index.php?rid=4969532&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01715.x The novel HLA‐C allele HLA‐C*07:147 contains one nucleotide substitution in exon 2 leading to an amino acid change in the alpha 1 domain from phenylalanine to leucine. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=4969532 Sat, 25 Jun 2011 23:00:00 +0100 4969532 http://www.medworm.com/index.php?rid=4969531&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01719.x A novel HLA allele, DRB3*01:15, was likely derived via cis‐gene conversion. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=4969531 Sat, 25 Jun 2011 23:00:00 +0100 4969531 http://www.medworm.com/index.php?rid=4935725&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01696.x (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=4935725 Sat, 18 Jun 2011 13:55:30 +0100 4935725 http://www.medworm.com/index.php?rid=4935724&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01713.x Antibodies against human leukocyte antigens (HLAs) have long been associated with transfusion‐related acute lung injury (TRALI). In contrast to febrile transfusion reactions and refractoriness to platelet transfusions in immunized patients, the causative antibodies in TRALI are present in the transfused blood component, i.e. they are formed by the blood donor and not by the recipient. Consequently, blood components with high plasma volume are particularly associated with TRALI. In addition to antibodies against HLAs, antibodies directed against human neutrophil antigens (HNAs) present in the plasma of predominantly multiparous female blood donors can induce severe TRALI reactions. Especially, antibodies to HLA class II and HNA‐3a antigens can induce severe or even fatal ALI in critical... Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=4935724 Sat, 18 Jun 2011 13:55:20 +0100 4935724 http://www.medworm.com/index.php?rid=4935722&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01706.x The B*51:79 allele displays a conserved haplotype association with HLA‐A*68:01, C*01:02, DRB1*14:01 and DQB1*05:03. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=4935722 Sat, 18 Jun 2011 13:55:00 +0100 4935722 http://www.medworm.com/index.php?rid=4935723&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01710.x This study used long‐range polymerase chain reaction to sequence 4.5 or 4.3 kb of genomic DNA covering human leukocyte antigen C (HLA‐C) and its flanks in 45 Chinese Han subjects to better characterize variation in the gene in a single population. Sequences of 35 HLA‐C alleles were obtained from the population, including major alleles of 13 lineages of HLA‐C. Four novel alleles, C*03:04:01:02, C*04:01:01:03, C*08:22, and C*17:01:01:02, were identified, and complete full‐length sequences of 18 HLA‐C alleles were obtained for the first time. All sequences herein reported also represent extensions through the promoter region and the 3′‐untranslated region. Fourteen 5′‐nucleotide sequences and 14 3′‐nucleotide sequences were detected outside the coding region. In total,... Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=4935723 Wed, 08 Jun 2011 23:00:00 +0100 4935723 http://www.medworm.com/index.php?rid=4903335&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01692.x MICA*063N has one nucleotide different from MICA*027 at position 184 (C→T) in codon 62 (CAG→TAG), resulting in a premature stop codon in exon 2. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=4903335 Mon, 06 Jun 2011 23:00:00 +0100 4903335 http://www.medworm.com/index.php?rid=4903338&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01677.x We report herein the identification of 18 novel Mafa‐A alleles in cynomolgus macaques of Vietnamese origin. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=4903338 Sun, 05 Jun 2011 23:00:00 +0100 4903338 http://www.medworm.com/index.php?rid=4903337&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01693.x In this study, we investigated the MICA transmembrane polymorphism in hepatocellular carcinoma (HCC) patients in South China Han population. We found that the MICA‐A5.1 polymorphism, which gives rise to a truncated protein, was increased in HCC patients compared with healthy controls (Pc = 0.036). Furthermore, we found that HCC patients with MICA‐A5.1 polymorphism had higher serum levels of soluble MICA (sMICA). These results suggest that MICA‐A5.1 polymorphism is associated with HCC patients in South China Han population and the MICA‐A5.1 polymorphism may contribute to the development of HCC by promoting the release of sMICA to evade tumor immunosurveillance. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=4903337 Sun, 05 Jun 2011 23:00:00 +0100 4903337 http://www.medworm.com/index.php?rid=4903336&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01700.x HLA‐DQB1*02:01:04 differs from DQB1*02:01:01 by one nucleotide (G>A) at position 303 in exon 2 resulting in a silent substitution (codon 69 – GAG >GAA), conserved glutamate. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=4903336 Sun, 05 Jun 2011 23:00:00 +0100 4903336 http://www.medworm.com/index.php?rid=4903334&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01709.x This work presents survival data of 42 melanoma patients at high risk for disease recurrence who received an allogeneic melanoma vaccine composed of three cell lines, each matching at least one allele of the recipient's human leukocyte antigen (HLA)‐A and ‐B loci. The 5‐year overall survival (OS) rate and disease‐free survival (DFS) compared favorably with the standard interferon‐α regimen. Interestingly, patients bearing HLA‐B35 had significantly better OS and DFS (OS of 100% and DFS of 90% for HLA‐B35 vs 56% and 23%, for the non‐B35 patients). In contrast, patients expressing HLA‐B07 did not fare well with the vaccine. Although the data include a relatively small cohort of patients, it strongly hints toward a correlation between HLA types and potential benefit from ant... Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=4903334 Tue, 31 May 2011 23:00:00 +0100 4903334 http://www.medworm.com/index.php?rid=4877284&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01698.x HLA‐DRB1*08:41 shows seven nucleotide differences from DRB1*08:18 and result in three amino acid changes. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=4877284 Mon, 30 May 2011 13:54:39 +0100 4877284 http://www.medworm.com/index.php?rid=4877288&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01685.x HLA‐B plays an important role in unrelated donor hematopoietic stem cell transplantation. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=4877288 Sun, 29 May 2011 23:00:00 +0100 4877288 http://www.medworm.com/index.php?rid=4877287&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01699.x Two new HLA‐C alleles, C*02:29 and C*06:29, and one new HLA‐DQB1 allele, DQB1*03:24, are described. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=4877287 Sun, 29 May 2011 23:00:00 +0100 4877287 http://www.medworm.com/index.php?rid=4877286&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01691.x (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=4877286 Sun, 29 May 2011 23:00:00 +0100 4877286 http://www.medworm.com/index.php?rid=4877285&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01702.x The interleukin 12 (IL‐12) cytokine, encoded by polymorphic genes, plays a central role in the T helper 1 cell‐mediated immunity against tumors. We investigated whether the 3′ untranslated region +1188 A/C polymorphism (rs 3212227) influences the nasopharyngeal carcinoma (NPC) risk in Tunisian patients. DNA analysis of 247 patients and 284 healthy individuals showed a higher frequency of the 1188 C allele and the CC genotype in patients than in controls (P = 0.00001and P = 0.00005) suggesting that the C variant allele is associated with the susceptibility to NPC. Additional testing showed that the homozygous CC genotype is also associated with advanced stage of the tumor extension at presentation (P = 0.022). Our data suggest that the impaired production of IL‐12 behaves as a risk ... Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=4877285 Sun, 29 May 2011 23:00:00 +0100 4877285 http://www.medworm.com/index.php?rid=4877293&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01697.x The HLA‐A*31:01:09 differs from the closest allele HLA‐A*31:01:02 by a C to T silent substitution at position 447 in exon 3. The HLA‐A*33:30 differs from the closest allele HLA‐A*33:03:01 by a single nucleotide substitution at position 453 in exon 3, leading to a change of Arg131Cys. (Source: Tissue Antigens) Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=4877293 Sat, 28 May 2011 23:00:00 +0100 4877293 http://www.medworm.com/index.php?rid=4877292&cid=s_33167_3_f&fid=33167&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-0039.2011.01707.x Inflammatory bowel disease (IBD) is thought to be the most common cause of vomiting and diarrhoea in dogs. Although IBD can occur in any canine breed, certain breeds are more susceptible. We have previously shown that polymorphisms in the TLR4 and TLR5 (toll‐like receptor) genes are significantly associated with IBD in German Shepherd dogs (GSDs). In order to allow for the development of novel diagnostics and therapeutics suitable for all dogs suffering from IBD, it would be useful to determine if the described polymorphisms are also significantly associated with IBD in other breeds. Therefore, the aim of this study was to investigate whether polymorphisms in the canine TLR4 and TLR5 genes are associated with IBD in other non‐GSD canine breeds.The significance of the previously identif... Tissue Antigens journals http://www.medworm.com/rss/comments.php?id=4877292 Sat, 28 May 2011 23:00:00 +0100 4877292