MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Transfusion Clinique et Biologique' source. Sun, 21 Mar 2010 15:13:23 +0100 http://www.medworm.com/index.php?rid=3280713&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20153674%26dopt%3DAbstract CONCLUSION: The study confirms the necessity to re-examine the French notification system. It underlines the insufficiency of clinical and biological investigations, which could allow to reach accurate diagnosis. It gives prominence the necessity of taking into account the patient's pathology and targets at least two diagnoses of transfusion adverse effects which are not yet proposed on the FEIR model. This work brings an overture about evolution of the French haemovigilance database which will involve further developments. PMID: 20153674 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=3280713 Thu, 11 Feb 2010 00:00:00 +0100 3280713 http://www.medworm.com/index.php?rid=3221481&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20106699%26dopt%3DAbstract Authors: Courbil R, Romaszko JP, Odent-Malaure H, Fabrigli P, Chavarin P, Tournilhac O, Bay JO, Fressy P, Ergani A, Bouvet A, Bonnet R, Garraud O We recently observed a near fatal case of transfusion-transmitted infection with standard platelet concentrate. Streptococcus dysgalactiae subspecies equisimilis was isolated both from donor, residual component container and cultures of the patient's blood. This should question the usefulness of systematic bacterial detection in platelet concentrates, however a lethal accident has occurred recently which escaped bacterial detection. This observation calls for implementation of pathogen inactivation procedures for platelets concentrates. PMID: 20106699 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=3221481 Mon, 25 Jan 2010 00:00:00 +0100 3221481 http://www.medworm.com/index.php?rid=3221480&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20106700%26dopt%3DAbstract CONCLUSION: Universal leukocyte reduction significantly reduced the rate of transfusion reactions. PMID: 20106700 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=3221480 Mon, 25 Jan 2010 00:00:00 +0100 3221480 http://www.medworm.com/index.php?rid=3221479&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20106701%26dopt%3DAbstract Authors: Lassale B, Legrand D, Chiaroni J The Marseille public hospital system (APHM) has expressed its willingness to pool its services of immunohematology and delivery of labile blood products with those of the French blood institute Alps Mediterranean division (EFS AM). An agreement setting out the terms of this partnership was signed between the two parties. The users of the APHM and EFS AM blood watch wished to preserve the channels of distribution. Implementation of this reorganization has focused on ensuring transfusional safety, reinforcing harmonization of APHM practices, and finding ways to reduce costs. Despite joint information campaigns (to medical and paramedical personnel) carried out by the APHM and EFS AM blood watch, problems have arisen during start-up and adjustment... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=3221479 Mon, 25 Jan 2010 00:00:00 +0100 3221479 http://www.medworm.com/index.php?rid=3136507&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20044293%26dopt%3DAbstract Authors: Lefrère JJ, Berche P The discovery of ABO blood group was a major step in mastering transfusion therapy. Karl Landsteiner (1868-1843) was the author of this discovery. This paper retraces the hard career of this American scientist of Austrian origin, and describes the circumstances that led his research to the discoveries, which were turning points in the history of the immunology. PMID: 20044293 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=3136507 Tue, 29 Dec 2009 00:00:00 +0100 3136507 http://www.medworm.com/index.php?rid=3136508&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20042357%26dopt%3DAbstract Authors: Viguier M, Pouthier F, Tiberghien P, Aubin F Photopheresis or extracorporeal photochemotherapy (ECP) is a cellular therapy which combines a leukapheresis followed by ex vivo treatment using psoralen and ultraviolet A irradiation before reinfusion into the patient. Its mechanisms of action remain unclear and selective photodestruction of leukocytes cannot explain the long-lasting immunomodulatory effects. Recent studies demonstrated that ECP down regulates the immune response and induces tolerance through the maturation of dendritic cells and the production of regulatory T cells. Based on these effects, ECP is mainly used for treatment of Sezary syndrome, graft-versus-host disease, organ graft rejection and autoimmune diseases. However, it is still not clear how ECP both activa... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=3136508 Mon, 28 Dec 2009 00:00:00 +0100 3136508 http://www.medworm.com/index.php?rid=3027974&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19932630%26dopt%3DAbstract Authors: Sghaier W, Hergon E, Bocquet JC, Desroches A The organisations' performance is not restricted to economic criteria, it integrates other dimensions: social, safety, quality, environmental, ethical, scientific... There are few multicriteria design and management methods for organisations. In this article, we propose an analysis and modelling method of the values creation based on systematic approach. This method enables to integrate all the stakeholders' points of view and expectations in order to have a global vision of the performance. We have applied this method to one French Blood Establishment process. PMID: 19932630 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=3027974 Fri, 20 Nov 2009 00:00:00 +0100 3027974 http://www.medworm.com/index.php?rid=3027973&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19932631%26dopt%3DAbstract Authors: Garraud O, Andreu G PMID: 19932631 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=3027973 Fri, 20 Nov 2009 00:00:00 +0100 3027973 http://www.medworm.com/index.php?rid=3027972&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19932632%26dopt%3DAbstract Authors: Ivanovic Z, Boiron JM A new discipline was born and grew up over the last 4 decades of 20th century: Experimental Hematology. In addition to yield the concept of Stemness, a paradigm later applied for the other tissues than hematopoietic one, it provided the results allowing a preclinical development and a therapeutic exploitation. The concept of ex vivo expansion of hematopoietic cells for transplantation is directly issued from this knowledge. It enabled us to realize that a critical quantity of different sub-populations of stem and progenitor cells are necessary to obtain a rapid and sustained hematopoietic reconstitution. These principles, transposed to human cells (originating from: bone marrow, peripheral blood, cord blood) required some important technological innovatio... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=3027972 Fri, 20 Nov 2009 00:00:00 +0100 3027972 http://www.medworm.com/index.php?rid=3017325&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19926508%26dopt%3DAbstract CONCLUSION: It emerges from this study that the risk of blood transmitted virus is always high. Introduction of more sensitive tests (as nucleic acid testing) would allow us to deliver more safety products. PMID: 19926508 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=3017325 Mon, 16 Nov 2009 00:00:00 +0100 3017325 http://www.medworm.com/index.php?rid=2981524&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19896404%26dopt%3DAbstract Authors: Diarra A, Kouriba B, Baby M, Murphy E, Lefrere JJ Good data on background seroprevalence of major transfusion transmitted infections is lacking in Mali. We gathered data on the rate of positive donations of human immunodeficiency virus (HIV), hepatitis C virus (HCV), hepatitis B virus (HBV) and syphilis among blood donations in Mali for calendar year 2007. Donations with repeatedly reactive results on screening enzyme immunoassay (EIA) were considered to be seropositive. Rate of positive donations per blood unit collected was 2.6% for HIV, 3.3% for HCV, 13.9% for hepatitis B surface antigen (HBsAg) and 0.3% for syphilis. For HIV, HBsAg and syphilis, rate of positive donations was significantly (p<0.001) higher among donations from replacement donors than those from voluntee... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=2981524 Wed, 04 Nov 2009 00:00:00 +0100 2981524 http://www.medworm.com/index.php?rid=2981523&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19896405%26dopt%3DAbstract We report the successive stages of the reorganization of the blood transfusion sector in Togo. The starting point was the elaboration of the national policy of blood transfusion, then the adoption of a decree organizing the sector as well the various decree of application, particularly that related to transfusion good practices. The current policy recommends two poles of qualification of the blood ant its components and the creation of six stations of collection and distribution attached to these poles. The reorganization started with the rehabilitation of the National Blood Transfusion Centre (CNTS) in Lomé. If the problem of human resources is alarming, especially the availability of hemobiologists, the rehabilitation allowed the increase of the blood collection passing from 5272 do... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=2981523 Wed, 04 Nov 2009 00:00:00 +0100 2981523 http://www.medworm.com/index.php?rid=2955622&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19880338%26dopt%3DAbstract CONCLUSION: Although the new process was supposed to be more efficient and easier for the user, the global result on traceability by users is negative after 18months. PMID: 19880338 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=2955622 Fri, 30 Oct 2009 00:00:00 +0100 2955622 http://www.medworm.com/index.php?rid=2955621&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19880339%26dopt%3DAbstract Authors: Servant-Delmas A, Mercier M, Laperche S, Lefrère JJ The B19 Parvovirus (B19V) has for a long time been considered as the unique human virus belonging to the genus Erythrovirus. The genetic diversity of B19V isolates has been shown to be very low. The isolation of a variant (V9 strain), with a sequence markedly distinct from that of B19V which led to attributing this classification to this family of viruses. Phylogenetic analysis of sequences of V9-related isolates indicates an organization into three well-individualized genotypes. The B19V infection can be transmitted by transfusion. In immunocompetent recipients, B19V exposure by transfusion is most often inconsequential, since a large proportion is immunized. Such an infection may have serious clinical outcome in not im... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=2955621 Fri, 30 Oct 2009 00:00:00 +0100 2955621 http://www.medworm.com/index.php?rid=2955623&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19879788%26dopt%3DAbstract Authors: El Bakkouri J, Mamdouh A, Faez S, Medkouri G, Ramdani B, Benchemsi N A 37-year-old patient with moderate haemophilia A and end-stage renal disease underwent kidney transplantation in the University Hospital Ibn Rochd of Casablanca (Morocco). He received factor VIII replacement therapy perioperatively and until the 21st day postoperation. So, the activity rates of Factor VIII was higher than or equal to 80 % in the day of intervention and two to three days later, then between 30 and 60 % until healing. The evolution of the patient to 28 months post-transplantation is marked by a good renal function without episode of rejection or bleeding complications. The heavy surgical interventions are possible in patients with haemophilia, but depend on good replacement therapy in peri- an... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=2955623 Thu, 29 Oct 2009 00:00:00 +0100 2955623 http://www.medworm.com/index.php?rid=2843157&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19783191%26dopt%3DAbstract Authors: Tayou Tagny C, Diarra A, Yahaya R, Hakizimana M, Nguessan A, Mbensa G, Nébié Y, Dahourou H, Tapko JB, Shiboski C, Murphy E, Lefrère JJ In subsaharan Africa, knowledge of the organization and methods of transfusion centers, as well as blood donor characteristics, is essential in choosing strategies to improve transfusion practices and the security of blood products on this Continent. The present study was based on a analysis led in partnership with the transfusion of seven francophone African countries (Burkina-Faso, Cameroon, Congo, Ivory Cost, Mali, Niger, and Rwanda). The results showed that withstanding significant progress has been realized in the organization and safety, but much remains to be undertaken over the years to come in order to improve the organi... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=2843157 Thu, 24 Sep 2009 23:00:00 +0100 2843157 http://www.medworm.com/index.php?rid=2843158&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19782626%26dopt%3DAbstract Authors: Roussel P, Moll MC, Lassale B, Ragni J Analysing adverse events is part of the medical practice in so far as the part it plays is outstanding in terms of feedback and improved healthcare safety. The integrated implementation of this practice is based on a four-dimensional system: strategic (corporate policies), cultural (safety-oriented cultural mindset), structural (dedicated organization and resources) and technical (methodologies and utilities). Two case studies illustrate the sequencing process from selecting the to-be-analyzed event down to figuring out the appropriate action plan. Beyond the visible and obvious origin, thanks to the implemented methods such as causal tree or ALARM method, far-fetched analysis elements and identified factors likely to explain events can b... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=2843158 Wed, 23 Sep 2009 23:00:00 +0100 2843158 http://www.medworm.com/index.php?rid=2801195&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19748813%26dopt%3DAbstract We report a female group A, D- patient with cerebrovascular disease who was induced to develop IgG immune anti-D which can be detected on the 15th day of hospitalization after the relatively regular time interval of transfusion of 1800ml apheresis FFP. Therefore, in making clinical decisions to transfuse FFP or apheresis FFP, the best choice is considered as the same or compatibility with RhD group, in case Rh immunization can be induced and trigger some potential serious problems in future emergent transfusion or pregnancy, especially in high incidence of D antigen countries. PMID: 19748813 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=2801195 Thu, 10 Sep 2009 23:00:00 +0100 2801195 http://www.medworm.com/index.php?rid=2753174&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19716739%26dopt%3DAbstract Authors: Peyrard T, Rouger P Since the discovery of blood groups in humans, several hundred new red blood cell antigens have been identified. Multiple terminology modes have been used to denote each new antigen identified, but without any consistent rules, nor international consensus. This was largely due to the many discoverers of these antigens, using either letters of the alphabet, numbers, part of the patient or donor's name, place of discovery or animal names. Besides, alternative terminologies for the Rh system were implemented in the middle of the twentieth century (Rosenfield, Fisher-Race, Wiener). The International Society of Blood Transfusion described for the first time in 1980 the advantages of an alphanumeric and homogeneous nomenclature, keeping with the genetic bases of ... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=2753174 Wed, 26 Aug 2009 23:00:00 +0100 2753174 http://www.medworm.com/index.php?rid=2725649&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19695921%26dopt%3DAbstract Authors: Tagny CT In a context of high prevalence of syphilis in blood donor and of resources-limited settings, this review aims to describe biological elements which are available for the screening of the disease and the essentials considerations which participate to choose a screening test in subsaharan Africa. Treponemics, non treponemics, immunochromatographics or nucleic, the type of the chosen screening test must contribute to the blood transfusion safety as well as be affordable. PMID: 19695921 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=2725649 Mon, 17 Aug 2009 23:00:00 +0100 2725649 http://www.medworm.com/index.php?rid=2692793&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19665412%26dopt%3DAbstract CONCLUSION: Plasmodium represents the third risk of blood transmitted infectious agents after hepatitis B virus, syphilis, and before HCV and HIV in Senegal. The medical questionnaire is not useful enough for asymptomatic carriers deferral, and we propose to introduce Plasmodium screening. The screening for Plasmodium pLDH by Elisa technique seems to be the best tool in endemic area and the strategy of systematic screening is the most suited in terms of blood transfusion safety. PMID: 19665412 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=2692793 Wed, 05 Aug 2009 23:00:00 +0100 2692793 http://www.medworm.com/index.php?rid=2692792&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19665413%26dopt%3DAbstract CONCLUSION: Use of these safety tools has improved the safety culture regarding transfusion of blood components in hematopoietic transplant recipients at our institution. PMID: 19665413 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=2692792 Wed, 05 Aug 2009 23:00:00 +0100 2692792 http://www.medworm.com/index.php?rid=2661272&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19640755%26dopt%3DAbstract Authors: Lefrère JJ, Shiboski C, Fontanet A, Murphy EL A two-week, French language, clinical research course in transfusion medicine has recently been created at the Pasteur Institute in Paris under the joint leadership of faculty members from the University of California San Francisco (UCSF), the Blood Systems Research Institute (BSRI) and the National Institute of Transfusion of Paris. The goal is to train transfusion professionals from the developing world to conduct clinical research that will contribute to improving the quality of care and safety in transfusion practices in their respective countries. The course provides training on clinical and epidemiological research methods and their potential applications in transfusion medicine. As part of the course, each student devel... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=2661272 Sun, 26 Jul 2009 23:00:00 +0100 2661272 http://www.medworm.com/index.php?rid=2661271&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19640756%26dopt%3DAbstract CONCLUSION: The concentrates, used by the anaesthesiologists, are part of the treatment strategy care in case of severe bleeding. PMID: 19640756 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=2661271 Sun, 26 Jul 2009 23:00:00 +0100 2661271 http://www.medworm.com/index.php?rid=2533692&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19375969%26dopt%3DAbstract Authors: Douay L One has been trying for several years to find a substitute for red blood cells (RBC). The development of chemical or natural molecules to replace hemoglobin has nevertheless proved difficult and artificial blood is still unattainable. We have described a methodology permitting the massive ex vivo production of mature human RBC having all the characteristics of native adult RBC from hematopoietic stem cells (HSC) of diverse origins: blood, bone marrow or cord blood. This protocol allows both massive expansion of the HSC/progenitors and their complete differentiation to the stage of perfectly functional mature RBC. The levels of amplification obtained (10(5) to 2x10(5)) are compatible with an eventual transfusion application. We discuss here the state of the art of this ... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=2533692 Thu, 30 Apr 2009 23:00:00 +0100 2533692 http://www.medworm.com/index.php?rid=2533690&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19386532%26dopt%3DAbstract CONCLUSION: Usefulness of blood group genotyping in specialized immunohematology laboratories is obvious. However, the strategy for implementation of molecular methods remains to be defined. Use of high-throughput DNA analysis should change our way of working. PMID: 19386532 [PubMed - in process] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=2533690 Thu, 30 Apr 2009 23:00:00 +0100 2533690 http://www.medworm.com/index.php?rid=2533688&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19409827%26dopt%3DAbstract Authors: Godeau B Immune thrombopenic purpura (ITP) is an autoimmune disease characterized by a peripheral destruction of platelets. B lymphocytes play a key role but pathophysiology is more complex, involving humoral and cellular immunity associated with an inappropriate platelet production. The treatment of ITP is still based on uncontrolled studies. Prednisone and intravenous immunoglobulins remain the first line treatments. Splenectomy remains the best "curative" treatment for adults with chronic ITP. However, most patients are reluctant to undergo surgery and new treatments give promising results. Among them, rituximab and thrombopoietin receptor agonists could replace splenectomy in near future. PMID: 19409827 [PubMed - as supplied by publisher] (Source: Transfusion Clinique ... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=2533688 Thu, 30 Apr 2009 23:00:00 +0100 2533688 http://www.medworm.com/index.php?rid=2533686&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19409828%26dopt%3DAbstract Authors: Kaplan C Fetal and neonatal alloimmune thrombocytopenias result from maternal immunization against fetal specific platelet antigens inherited from the father that the mother lacks. The incidence has been estimated to one in 800 to one in 1000 live births. The most feared complication in case of severe thrombocytopenia is the occurrence of intracranial hemorrhage, leading to death or neurological sequelea. The diagnosis is straightforward when a maternal alloantibody is detected and the offending antigen identified in the infant. Any difficulties in confirming the diagnosis should not delay the treatment. Since the first description of these conditions in the 1950's, significant progress has been made in laboratory diagnosis and management. PMID: 19409828 [PubMed - in proce... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=2533686 Thu, 30 Apr 2009 23:00:00 +0100 2533686 http://www.medworm.com/index.php?rid=2533684&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19409829%26dopt%3DAbstract Authors: Bertrand G, Kaplan C Platelet alloantigens named Human Platelet Antigens (HPA) are involved in immune conflicts such as post-transfusion purpura, platelet transfusion refractoriness and neonatal alloimmune thrombocytopenia. Biological diagnosis relies on: (1) detection of alloantibodies; (2) identification of the alloantigen involved in the immune conflict. Since the development of methods based on molecular biology, platelet genotyping is preferred to phenotyping. Today, most of the Platelet Immunology Units use PCR-RFLP or PCR-SSP, and few use real-time PCR. An increasing amount of commercial kits based on new technologies is now available, for example microarrays, fluorescent or coloured microbeads, or a combination of both technologies. However, an increasing number of pol... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=2533684 Thu, 30 Apr 2009 23:00:00 +0100 2533684 http://www.medworm.com/index.php?rid=2533682&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19409830%26dopt%3DAbstract The objective of this article is to update the last estimates of residual risks of the major transfusion-transmitted viral infections (HIV, HTLV, HCV and HBV) and to present the work realized by the working group << Quantitative estimate of the risk of blood donation contamination by infectious agents>>. PMID: 19409830 [PubMed - in process] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=2533682 Thu, 30 Apr 2009 23:00:00 +0100 2533682 http://www.medworm.com/index.php?rid=2533681&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19419894%26dopt%3DAbstract Authors: Mannessier L Despite the generalization of immunoprophylaxis by anti-RH immunoglobulins over 40 years, fetomaternal incompatibility due to RH1 antigen (RhD) is not completely eradicated, although perinatal consequences might be extremely serious. Additionally, allo-immunizations against other antigens, especially anti-RH4 (anti-c) and anti-KEL1 (anti-Kell), may cause severe haemolytic disease. Follow-up of allo-immunization during pregnancy and its prevention are therefore still a concern for all pregnant women. Immunohaematological tests used in antenatal patients are under practice for a long time. However, despite significant progress, it is clear that these tests provide only an indirect indication and will only help the obstetrician, in conjunction with over fetal paramet... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=2533681 Thu, 30 Apr 2009 23:00:00 +0100 2533681 http://www.medworm.com/index.php?rid=2533680&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19427252%26dopt%3DAbstract Authors: Blajchman MA As a consequence of the many blood-safety interventions introduced since the mid-1980s, the major causes of transfusion-associated mortality have shifted from being mainly due to transfusion-transmitted infections (TTIs) to being mainly due to non-infectious serious events such as TRALI, hemolytic reactions, transfusion overload, and graft versus host disease. Thus, TTIs now account for only 10 to 15% of all transfusion associated mortalities! Relevantly, manufacturers of purified plasma protein fractions have, over the same time period, shown that pathogen inactivation technologies can be successfully implemented resulting in little or no transmission of HIV, HCV or HBV since the late 1980s. These technologies, however, cannot be applied to cellular blood compone... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=2533680 Thu, 30 Apr 2009 23:00:00 +0100 2533680 http://www.medworm.com/index.php?rid=2533678&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19442551%26dopt%3DAbstract Authors: Marimbert J PMID: 19442551 [PubMed - in process] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=2533678 Thu, 30 Apr 2009 23:00:00 +0100 2533678 http://www.medworm.com/index.php?rid=2533676&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19442552%26dopt%3DAbstract Authors: Verfaillie C The isolation of human embryonic stem cells (ESC) in 1998 has created the hope that stem cells will one day be used to regenerate tissues and organs, even though it is obvious that a number of hurdles will need to be overcome for such therapies to become reality. The cloning of "Dolly" in 1997, more than 40 years after the first frogs were cloned, combined with the very fast progress made in our understanding of the molecular processes that govern the pluripotency of ESC has lead to the ability of scientists to recreate a pluripotent state in fibroblasts and other cells from mouse, rat and man, named induced pluripotent stem cells (iPSC). This feat makes it theoretically possible to create patient specific pluripotent stem cells whose differentiated progeny could ... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=2533676 Thu, 30 Apr 2009 23:00:00 +0100 2533676 http://www.medworm.com/index.php?rid=2533674&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19442553%26dopt%3DAbstract Authors: Schneider T The need of plasma derivatives increases in France. The Etablissement français du sang (EFS) carries out plans for supplying plasma to the Laboratoire français du fractionnement et des biotechnologies (LFB). Different kinds of actions are taken or will be taken according to the way of plasma processing. For plasma issued from whole blood, the increase is correlated with the increase of whole blood collection for the patients' need of red cells concentrates and the optimized plasma volume of plasma concentrate. For plasma issued from combined aphaeresis and the production of pooled platelets concentrates, synthetic media is favoured. Plasma aphaeresis is a specific way to satisfy requirements of the LFB. Communication choice of the blood collection's place... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=2533674 Thu, 30 Apr 2009 23:00:00 +0100 2533674 http://www.medworm.com/index.php?rid=2533672&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19442554%26dopt%3DAbstract Authors: Rouger P Learned societies are a reality in the medical sector. They are currently tending to become a federation of professionals, which targets are to secure the independence of training programs and perpetuate the scientific knowledge of blood transfusion. This is the way the French Society of Blood Transfusion (SFTS) built its role and scope of action in the service of patients. PMID: 19442554 [PubMed - in process] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=2533672 Thu, 30 Apr 2009 23:00:00 +0100 2533672 http://www.medworm.com/index.php?rid=2533670&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19442555%26dopt%3DAbstract Authors: Courbil R, Fabrigli P, Garraud O In this article, we present transfusion counseling; its organization, actors, their formations and we deal with factual positions. Transfusion counseling needs better identification, tending to a homogeneous organization between every bloodbank centre. PMID: 19442555 [PubMed - in process] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=2533670 Thu, 30 Apr 2009 23:00:00 +0100 2533670 http://www.medworm.com/index.php?rid=2533668&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19442556%26dopt%3DAbstract Authors: Faber JC Since 2002, major progress has occurred worldwide in the context of haemovigilance and significant improvement of the blood chain has come out as a result. Nevertheless different scenarios exist throughout the European Union and outside of Europe: the systems are mandatory or voluntary, notification is required for recipients, donors, processes or activities in the broad context of blood component transfusion. Differing from country to country, notification is mandatory for all adverse reactions or only for serious ones; and so it is with adverse events. Under-reporting is generally considered to be the most important single problem. But there is no doubt that haemovigilance will continue to help improve quality and safety of blood transfusion. PMID: 19442556 [Pub... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=2533668 Thu, 30 Apr 2009 23:00:00 +0100 2533668 http://www.medworm.com/index.php?rid=2533666&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19442557%26dopt%3DAbstract Authors: Lefrère JJ, Coudurier N Donor and recipient sample biobanks are a precious tool in hemovigilance studies as well as in epidemiological and biological research, in particular with regards to safety against blood-borne agents. This paper describes the main transfusion biobanks existing in France and gives their advantages and limits. The National blood donation biobank, organized for medicolegal reasons, preserves samples of each blood donation for a 5-year period. The biobank of the Blood and Organ Transmissible Infectious Agents (BOTIA) project stocks paired donor-recipient samples with a research objective. Preserved over a long period of time, such transfusion biobanks will be useful in terms of public health, as a reflection of the biological state of a population at a... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=2533666 Thu, 30 Apr 2009 23:00:00 +0100 2533666 http://www.medworm.com/index.php?rid=2533664&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19442558%26dopt%3DAbstract Authors: Ozier Y, Mertes PM Transfusion-related acute lung injury (TRALI) is the inflammatory, exudative form and Transfusion-associated cardiac overload (TACO) is the hydrostatic, transudative form of transfusion-induced acute pulmonary edema. The distinction between these two entities may be difficult, but important because of different clinical management strategies and different implications. There is no unique diagnostic tool. The diagnostic search should gather several clinical information and may be helped by various techniques listed in this article. PMID: 19442558 [PubMed - in process] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=2533664 Thu, 30 Apr 2009 23:00:00 +0100 2533664 http://www.medworm.com/index.php?rid=2533662&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19443249%26dopt%3DAbstract Authors: Tiberghien P, Chabod J, Deconinck E, Pouthier F A cord blood graft is now frequently used in the context of allogeneic hematopoietic transplantation. In 2007, 27% of unrelated allotransplantations performed in France used a cord blood graft. In comparison to other sources of hematopoietic grafts, cord blood has a number of advantages (immediate availability of the graft, possibility of a lesser HLA compatibility between donor and recipient...) and inconveniences (a limited number of stem cells, increased risk of infectious complications...). Recently, the possibility of combining two cord blood grafts has been demonstrated. In 2007, 55% of unrelated cord blood grafts transplantation were performed as such. Results of multicentric studies published as of now, as well as conside... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=2533662 Thu, 30 Apr 2009 23:00:00 +0100 2533662 http://www.medworm.com/index.php?rid=2533660&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19443250%26dopt%3DAbstract Authors: Danic B, Bigey F The ministerial decree of 12 January 2009 fixing the criteria for the selection of blood donors establishes the list of contraindications for blood donation according to the appendix to the European directive 2004/33/EC. This text regroups the preexisting guidelines and reinforces their regulatory status, which illustrates the importance attributed to the selection of donors within the dispositions ensuring transfusion safety. It introduces more flexibility with respect to the preexisting criteria taking into account the improvement in life expectancy and the continual increase in transfusion requirements. Thus, the rules for donation authorize up to 24 donations annually and one may give whole blood up to six times per year for men and four times for women, u... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=2533660 Thu, 30 Apr 2009 23:00:00 +0100 2533660 http://www.medworm.com/index.php?rid=2533658&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19443251%26dopt%3DAbstract Authors: Bierling P Although a number of research have been realized in the aim to rationalize the use of platelet concentrates, these blood products remain absolutely necessary for patients with therapeutic aplasia and for some surgical patients. We will discuss in this work: the main rules of platelet transfusion procedures, threshold values for platelet transfusion, platelet doses, place of curative and prophylactic strategies, refractoriness to platelet transfusion, HLA immunization. PMID: 19443251 [PubMed - in process] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=2533658 Thu, 30 Apr 2009 23:00:00 +0100 2533658 http://www.medworm.com/index.php?rid=2533656&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19443252%26dopt%3DAbstract Authors: Naegelen C, Isola H, Dernis D, Maurel JP, Tardivel R, Bois S, Vignoli C, Cazenave JP The techniques for inactivation of pathogens in labile blood products (LBP) would appear to be the new strategy which will permit us to increase transfusion safety in the face of the risks of transmission of pathogenic agents by LBP. Various methods are in the course of development or already validated and used in France. The latter only apply however to plasma or platelet concentrates. The mechanisms of action and the efficacy of inactivation and attenuation of pathogenic agents vary with the different techniques. Each of these constitutes a preparative procedure composed of unit steps which have to be fully mastered in order to ensure the quality and transfusion efficacy of the treated produ... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=2533656 Thu, 30 Apr 2009 23:00:00 +0100 2533656 http://www.medworm.com/index.php?rid=2533654&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19443253%26dopt%3DAbstract Authors: Garraud O, Cognasse F Platelets exert not only hemostatic activities, but also pro-inflammatory effects. Platelet-linked inflammation seems essentially related to their capacity of secreting cytokines, chemokines and related molecules. This activity is important in terms of concentration of secreted products. This secretory function confers to platelets a regulatory role in immunity. Besides, platelets do exhibit non-self infectious danger detection molecules on their surfaces, belonging in particular to the "Toll-like receptor family"; through this property, platelets can bind infectious agents but also deliver differential signals for the secretion of cytokines and chemokines. Platelets, which are non-nucleated cells deprived of nuclear DNA, possess however some cellular mac... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=2533654 Thu, 30 Apr 2009 23:00:00 +0100 2533654 http://www.medworm.com/index.php?rid=2533652&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19443254%26dopt%3DAbstract Authors: Galeotti C, Maddur MS, Kazatchkine MD, Mouthon L, Kaveri SV Despite their widespread use since many years in autoimmune and inflammatory disorders, the mechanisms of action of IVIg have not been completely understood. These mechanisms depend on Fc and/or F(ab')2. IVIg interacts with the different components of the immune system: Fc receptors, complement, cytokines, T and B lymphocytes, dendritic cells, granulocytes and NK cells. Here, we discuss the recent advances in the understanding of the mechanisms of action of IVIg, in particular the importance of the sialylated Fc fragment. These advances maybe help us conceive better therapeutic strategies against autoimmune and inflammatory disorders. PMID: 19443254 [PubMed - as supplied by publisher] (Source: Transfusion Clinique... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=2533652 Thu, 30 Apr 2009 23:00:00 +0100 2533652 http://www.medworm.com/index.php?rid=2533650&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19443255%26dopt%3DAbstract Authors: Lemarchand P Despite important progress in cardiology, acute myocardial infarction (AMI) is the major cause of congestive heart failure and subsequent mortality. The rationale for cell therapy to be administered after AMI is derived from the assumption that given the insufficient regeneration in the injured heart tissue, stem cells from the bone marrow may be able to replace or repair damaged vascular and cardiac tissue. Results of the first phase I clinical trials using bone marrow stem/progenitor cell therapy for AMI were published in 2002 to 2004. Although not designed to test the efficacy of the intervention, the initial trials indicated a promising improvement in a number of clinical outcomes and cardiac function and suggested the intervention was safe. Recently, randomiz... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=2533650 Thu, 30 Apr 2009 23:00:00 +0100 2533650 http://www.medworm.com/index.php?rid=2533648&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19443256%26dopt%3DAbstract Authors: Behr-Gross ME In the context of increased demand of blood components, it is highly desirable to ensure development and implementation of established standards for ethical, organisational and regulatory fields in order to guarantee the sufficiency, quality and safety of blood components and their derivatives as well as the protection of donors and recipients. In Europe, the contributions of the European public institutions is fundamental for the achievement of these goals and for the harmonisation of practices inherent to transfusional medicine activities. The Council of Europe with its 47 member states constitutes the ideal platform to tackle these themes: for half a century, its public health and bioethics experts have contributed to the elaboration of conventions and recomme... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=2533648 Thu, 30 Apr 2009 23:00:00 +0100 2533648 http://www.medworm.com/index.php?rid=2533646&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19443257%26dopt%3DAbstract Authors: Andreu G, Vasse J, Tardivel R, Semana G The quality of platelet concentrates had been greatly improved since the implementation of processing techniques based on the use of the buffy-coat in the years 1980. More recently, in the last 10 years, it is in the domain of safety that the greatest advances have been done, by the introduction of platelet additive solutions, on one hand, and by the progressive availability of pathogen reduction techniques, on the other hand. These developments in quality and safety of platelet components are important, as they lead to the conclusion that nowadays, apheresis platelet concentrates and pooled random donor platelet concentrates can be considered as equivalent, the only specific indication of the former being the care of HLA or HPA allo-imm... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=2533646 Thu, 30 Apr 2009 23:00:00 +0100 2533646 http://www.medworm.com/index.php?rid=2533644&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19446482%26dopt%3DAbstract Authors: Vaquier C, Legrand D, Caldani C Since 1985, a Council Resolution defines a new approach to technical harmonization and standards. The directives resulting from this new approach establish the essential safety requirements with which products put on the market must conform, and which should therefore enjoy free movement throughout the European Union, owing to a presumption of conformity. However, if the manufacturer is responsible for the conformity of its product in terms of safety, it is the end-user who must make sure that its requirements for a specific use or a considered application are satisfied and that the product meets its needs. It is the objective of the procedure of validation, which calls upon protocols of qualification intended to show the aptitude of a material,... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=2533644 Thu, 30 Apr 2009 23:00:00 +0100 2533644 http://www.medworm.com/index.php?rid=2533642&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19446483%26dopt%3DAbstract CONCLUSIONS: These experiences, implemented in two BTE for different processes, confirm the applicability and usefulness of these methods to improve working organisations in BTE. PMID: 19446483 [PubMed - in process] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=2533642 Thu, 30 Apr 2009 23:00:00 +0100 2533642 http://www.medworm.com/index.php?rid=2533640&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19446484%26dopt%3DAbstract Authors: Renaudier P, Rebibo D, Waller C, Schlanger S, Vo Mai MP, Ounnoughene N, Breton P, Cheze S, Girard A, Hauser L, Legras JF, Saillol A, Willaert B, Caldani C Pulmonary oedemas occurring during or after a blood transfusion appear as the most frequent serious immediate incidents in the French hemovigilance database. They include transfusion-associated circulatory overload (TACO) and transfusion-related acute lung injury (TRALI). TACO are a major cause of transfusion-related death in France. TRALI are more and more recognized and notified. In no case, pooled fresh frozen plasma (100 donations) treated with solvent-detergent were involved in French TRALI cases. A logigrame will allow hemovigilance officers to better classify pulmonary oedemas in e-fit, the French hemovigilance databa... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=2533640 Thu, 30 Apr 2009 23:00:00 +0100 2533640 http://www.medworm.com/index.php?rid=2533638&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19446485%26dopt%3DAbstract Authors: Tardivel R, Bois S, Vignoli C, Naegelen C, Isola H The preparation of labile blood products in a blood bank is in permanent technological progress. Many operations, such as blood centrifugation, components separation, etc. are now performed by automated devices. A new generation of equipments is able to prepare blood products by reducing the number of manual operations. Therefore, buffy-coat platelet concentrate preparation and whole blood preparation can be prepared by these automated systems. Consequently, this directly impacts working conditions of employees, quality of blood products and process management. PMID: 19446485 [PubMed - in process] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=2533638 Thu, 30 Apr 2009 23:00:00 +0100 2533638 http://www.medworm.com/index.php?rid=2533636&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19447060%26dopt%3DAbstract This article explains the scientific data and models on that type of systemic control and proposes a factual application to transfusion. PMID: 19447060 [PubMed - in process] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=2533636 Thu, 30 Apr 2009 23:00:00 +0100 2533636 http://www.medworm.com/index.php?rid=2533694&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19372060%26dopt%3DAbstract CONCLUSIONS: Even when sociodemographic variables and self-rated health are considered, socioeconomical status stays associated to blood donor status. Thus, this article highlights the importance of socioeconomic status in the blood donors' population structure. This study also shows that occasional donors, that should be resensitized, belong to the same socioeconomical categories than regular donors. Finally, this article provides research and sensitizing clues for some of the socioeconomic status analysed. PMID: 19372060 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=2533694 Mon, 13 Apr 2009 23:00:00 +0100 2533694 http://www.medworm.com/index.php?rid=2533696&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19369104%26dopt%3DAbstract This study aims to assess the short-term efficiency of the red cell transfusion in SCD homozygous form. One hundred and twelve homozygous sickle-cell patients were enrolled in this prospective study: 59 females and 53 males, median age is 21,8 years (extremes: 2 and 45 years). These patients are mostly with very low income. Two groups of patients are included in this study. In the first group, patients present acute anemia crisis caused by infections disease (malaria, bacterial infections). In the second group (20 cases), SCD patients have particularly situations: pregnancy (10 cases); stroke (six cases); cardiac failure (two cases) and priapism (two cases). Transfusion treatment in first group is simple regimen. Transfusion of EC increased median Hb level at 2,9g/dl (extremes: 1,1 and 4,7... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=2533696 Sun, 12 Apr 2009 23:00:00 +0100 2533696 http://www.medworm.com/index.php?rid=2309304&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19329346%26dopt%3DAbstract We report a case of Wilson's disease revealed by acute intravascular repeating hemolytic anemia associated with liver failure. The initially negative etiologic investigation was directed by occurred of liver failure. The genetic study allowed to discover an other similar case. The evolution was favourable under treatment with zinc sulfate and penicillamine. DISCUSSION: Diagnosis of Wilson's disease must be considered in case of acute hemolytic anemia associated with liver failure in young adults. PMID: 19329346 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=2309304 Fri, 27 Mar 2009 04:00:00 +0100 2309304 http://www.medworm.com/index.php?rid=2309306&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19328031%26dopt%3DAbstract CONCLUSION: In about three cases out of four, transfusion-induced hypotension was associated with other clinical reactions. Indeed, hypotensive transfusion reactions were identified, having an incidence of 3.2 for 100000 blood units transfused. Furthermore, there was no explanation found for the incidence increase in our region during 2007. A national study was suggested to analyse the national data as well as a prospective study to clear out this type of transfusion reactions. PMID: 19328031 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=2309306 Wed, 25 Mar 2009 04:00:00 +0100 2309306 http://www.medworm.com/index.php?rid=2309308&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19324582%26dopt%3DAbstract Authors: Courbil R, Fabrigli P, Benamara H, Chavarin P, Bregeon M, Ruyer-Dumontier P, Goure D, Paulin P, Froget A, Taibi K, Rigal E, Garraud O We represent an organization of transfusionnel advice at a regional level and we develop arguments and stages having allowed us to lead to this choice. This target was reached in two stages, which took place over 3 years. The regional transfusionnel advice leans on three fundamental points: a planned permanent organization, skilled and formed actors as well as adapted tools. Tending to a homogeneous organization between every blood bank center seems to be coherent towards the current configuration of blood donation in France. PMID: 19324582 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=2309308 Tue, 24 Mar 2009 04:00:00 +0100 2309308 http://www.medworm.com/index.php?rid=2309310&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19318287%26dopt%3DAbstract Authors: Quaranta JF, Berthier F, Courbil R, Courtois F, Chenais F, Waller C, Leconte des Floris MF, Andreu G, Fontaine O, Le Niger C, Puntous M, Mercadier A, Nguyen L, Pélissier E, Gondrexon G, Staccini P, During the years 1994-2001, a progressive decrease of the number of blood units transfused has been reported in France. In contrast, since 2002, there is an increasing number of blood units issuing (+7.6% between 2001 and 2006) and this must be investigated. On behalf of the French Society of Blood Transfusion, the "Recipients" working group promoted a nation wide survey with the support of the regional blood transfusion centres. This survey was aimed at describing the profiles of the transfused patients: socio-demographical patterns, and reasons of the blood transfusion (main... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=2309310 Fri, 20 Mar 2009 04:00:00 +0100 2309310 http://www.medworm.com/index.php?rid=2288587&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19299180%26dopt%3DAbstract Authors: Roussel P, Lassale B Incidents and accidents analysis is one part of risk management in healthcare organisations. It is based on methods such as healthcare process analysis and the Association of Litigation and Risk Management (ALARM) method, to understand not only immediate causes but also root causes. The goal is to implement relevant remedial and preventive actions to secure healthcare processes. The hospital's risk management unit has to be involved in the methodological analysis of every grade zero transfusion incident. The system is based on a retrospective analysis process in compliance with the French National Authority for Health's ongoing requirements for risk reactive approach, allowing to identify failures and start relevant actions. Healthcare teams should overcom... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=2288587 Tue, 17 Mar 2009 04:00:00 +0100 2288587 http://www.medworm.com/index.php?rid=2277576&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19297222%26dopt%3DAbstract Authors: Courbil R, Gras A, Motta Cano A, Chenus F, Julien H, Garraud O Award ceremonies constitute an insigne mean of promotion among the blood donor population, and also the general population. They contribute to the development of blood donation loyalty. Even so, their organization must be rigorously and perfectly codified. With this aim, the établissement français du sang Auvergne-Loire, in partnership with the departmental representation of the blood donors national federation, worked out a guide for their associations. PMID: 19297222 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=2277576 Mon, 16 Mar 2009 04:00:00 +0100 2277576 http://www.medworm.com/index.php?rid=2173556&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19200762%26dopt%3DAbstract Authors: Cappellesso-Fleury S, Rage C, Tschaggeny F, Gaudé J, Gomez M, Bourin P ABO-incompatible bone marrow transplantation requires red blood cell depletion. Lots of laboratory adopted the technique of density gradient centrifugation (Ficoll-hypaque) using the COBE 2991 cell processor with simple-bag processing set. However, tubing of this set is not adapted to the currently available peristaltic pumps. Moreover, two other sets are required: one for the buffy-coat and one for postgradient cell washing. We developed a method using triple-bag processing set to conduct whole-step procedure (concentration, Ficoll and washing). Peristaltic PVC tubing is provided in one line of the set allowing a safe processing without several connections thus reducing risks of microbial contaminatio... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=2173556 Wed, 04 Feb 2009 05:00:00 +0100 2173556 http://www.medworm.com/index.php?rid=2129461&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19026581%26dopt%3DAbstract CONCLUSION: To insure optimal transfusion safety for sickle cell disease patients, three points have to be improved: blood donation within the Afro-Caribbean community living in France, access to history of immuno-hematological data, detection of variant antigens, especially within the RH blood system. PMID: 19026581 [PubMed - in process] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=2129461 Mon, 01 Dec 2008 05:00:00 +0100 2129461 http://www.medworm.com/index.php?rid=2129460&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19026582%26dopt%3DAbstract This article presents epidemiological and molecular characterizing this new viral family. PMID: 19026582 [PubMed - in process] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=2129460 Mon, 01 Dec 2008 05:00:00 +0100 2129460 http://www.medworm.com/index.php?rid=2129459&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19026583%26dopt%3DAbstract Authors: Guyard A, Albarède S, Mannessier L, Rouger P, Dumont G Further to a survey set up in 2006 over 2600 laboratories by the French agency for health product safety (AFSSAPS), seven ABO grouping errors and 53 negative answers to red blood cell antibody screening with a serum containing anti-RH1 antibody, have been found. A questionnaire sent to the involved laboratories revealed non-analytical errors already met in previous cases. Besides, the analytical stage has also induced red blood cell antibody screening errors due to a wrong serum collection by the automat. Here are displayed the analysis of the questionnaire results and proposed corrections. PMID: 19026583 [PubMed - in process] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=2129459 Mon, 01 Dec 2008 05:00:00 +0100 2129459 http://www.medworm.com/index.php?rid=1991795&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19026581%26dopt%3DAbstract CONCLUSION: To insure optimal transfusion safety for sickle cell disease patients, three points have to be improved: blood donation within the Afro-Caribbean community living in France, access to history of immuno-hematological data, detection of variant antigens, especially within the RH blood system. PMID: 19026581 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1991795 Wed, 19 Nov 2008 05:00:00 +0100 1991795 http://www.medworm.com/index.php?rid=1991794&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19026582%26dopt%3DAbstract This article presents epidemiological and molecular characterizing this new viral family. PMID: 19026582 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1991794 Wed, 19 Nov 2008 05:00:00 +0100 1991794 http://www.medworm.com/index.php?rid=1991793&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19026583%26dopt%3DAbstract Authors: Guyard A, Albarède S, Mannessier L, Rouger P, Dumont G Further to a survey set up in 2006 over 2600 laboratories by the French agency for health product safety (AFSSAPS), seven ABO grouping errors and 53 negative answers to red blood cell antibody screening with a serum containing anti-RH1 antibody, have been found. A questionnaire sent to the involved laboratories revealed non-analytical errors already met in previous cases. Besides, the analytical stage has also induced red blood cell antibody screening errors due to a wrong serum collection by the automat. Here are displayed the analysis of the questionnaire results and proposed corrections. PMID: 19026583 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1991793 Wed, 19 Nov 2008 05:00:00 +0100 1991793 http://www.medworm.com/index.php?rid=1939887&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18951820%26dopt%3DAbstract Authors: Renaudier P Predicting transfusion requirements relies both on epidemiology and therapeutic changes in hematology. The incidence rate of B-cell neoplasias especially non-Hodgkin lymphoma and myelodysplasia is increasing. Chemotherapy related myelodysplasia will reflect the improvement of solid tumor prognostic in the future. For myelodysplasias, therapeutic changes including oral iron chelators and more intensive transfusion policies will likely result in an increase of PRC requirements, a situation shared by sickle-cell disease. PMID: 18951820 [PubMed - in process] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1939887 Sat, 01 Nov 2008 04:00:00 +0100 1939887 http://www.medworm.com/index.php?rid=1911696&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18951056%26dopt%3DAbstract Authors: Lagneaux MC Blood transfusion is a medical act which a nurse or midwife can do with a medical consent and only if a doctor can intercede when he is called. The following presentation reminds us of the nurse's and midwife's responsability when doing a blood transfusion. All the guidelines are laid down in the Public Health Code for nurses and midwifes as well as in the circular of the 15December 2003. The nurse or midwife doing the transfusion must at all times respect the security guidelines, doing so along with close collaboration between nurse, midwife and doctor enables all transfusions to be conducted safely. PMID: 18951056 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1911696 Wed, 22 Oct 2008 04:00:00 +0100 1911696 http://www.medworm.com/index.php?rid=1907961&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18948049%26dopt%3DAbstract Authors: Colin Y, Rahuel C, Wautier MP, El Nemer W, Filipe A, Cartron JP, Le Van Kim C, Wautier JL Recent studies shed new lights on the biological function of blood group antigens, such as the adhesion properties of the Lutheran (Lu) blood group antigens carried by the Lu/BCAM glycoproteins. The Lu/BCAM adhesion glycoproteins were first identified as laminin-10/11 erythroid receptors involved in RBC adhesion to endothelium in sickle cell anemia. Lu/BCAM mediated cell adhesion to laminin is stimulated by epinephrine, a physiological stress mediator, and is dependent of phosphorylation by protein kinase A. More recently, we demonstrated that constitutive phosphorylation of Lu/BCAM is also involved in abnormal RBC adhesion to endothelium in patients with polycythemia vera (PV), a frequen... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1907961 Tue, 21 Oct 2008 04:00:00 +0100 1907961 http://www.medworm.com/index.php?rid=1895742&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18938098%26dopt%3DAbstract Authors: Aullen JP, Lassale B, Verdot JJ From 2005, PACA area has formed think-tank group a priori risk in the transfusional chain. It has enabled to determine each step of the elementary process and evaluate the frequency, the seriousness and critical effect of the errors. Blood sample and conformity are the most critical points and depend on the vigilance identity. In September 2007, the southern blood bank of France has settled 12 nonconformities levels of blood samples. They send the listing of the nonconformities every month. This listing enables the executive staff to determine the errors and, therefore, to solve them. The regional notification of 2007 to 2008 confirms analysis of the think-tank team. Hence, we were able to list the most serious cases. Publics and privates hospit... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1895742 Sat, 18 Oct 2008 04:00:00 +0100 1895742 http://www.medworm.com/index.php?rid=1895741&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18938099%26dopt%3DAbstract Authors: Doly A, Fressy P, Garraud O The French Health Products Safety Agency coordinates the national initiative of computerization of blood products traceability within regional blood banks and public and private hospitals. The Auvergne-Loire Regional French Blood Service, based in Saint-Etienne, together with a number of public hospitals set up a transfusion data network named EDITAL. After four years of progressive implementation and experimentation, a software enabling standardized data exchange has built up a regional nominative database, endorsed by the Traceability Computerization National Committee in 2004. This database now provides secured web access to a regional transfusion history enabling biologists and all hospital and family practitioners to take in charge the patient ... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1895741 Sat, 18 Oct 2008 04:00:00 +0100 1895741 http://www.medworm.com/index.php?rid=1895740&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18938100%26dopt%3DAbstract Authors: Frimat L Population-based study suggests that chronic kidney disease is frequent. Almost one third of people older than 70 years of age would have a significant decrease in renal function. Anemia appears when glomerular filtration rate falls under 40mL per minute per 1.73m(2). Concurrently with supplementary iron, erythropoiesis-stimulating agents (ESA) allow a strict control of hemoglobin. However, incomplete responses to ESA are possible. The following conditions - inflammatory disorders, chronic blood loss, hyperparathyroidism, surgical process, chronic diseases, adverse effects of immunosuppressive agents - may cause apparent resistance to ESA therapy. All these conditions may request transfusion. PMID: 18938100 [PubMed - as supplied by publisher] (Source: Transfusion ... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1895740 Sat, 18 Oct 2008 04:00:00 +0100 1895740 http://www.medworm.com/index.php?rid=1895755&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18930678%26dopt%3DAbstract Authors: Boisson C, Cuvillon P, Macheboeuf M, Ripart J During the years 1990, the focus was on transfusion hazards and blood savings strategies. This resulted in a decrease in labile blood products consumption. For a few years, there is a reverse tendency, with a reincrease in blood products consumption. In the same time, the limit of saving strategies has been attained, by identifying the risk of lack of transfusion (or too low transfusion threshold). A so-called multimodal blood savings strategy must be set. Vigilance is mandatory concerning the blood savings strategies that are detailed by scientific societies consensus conferences. Those strategies include a good anticipation of blood requirement, improvement of surgical techniques, pre- and intra-operative autologous transfusion, ... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1895755 Fri, 17 Oct 2008 04:00:00 +0100 1895755 http://www.medworm.com/index.php?rid=1895754&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18930679%26dopt%3DAbstract Authors: Carre J To manage the filing of blood components at the hospital of the city of Bayeux, the laboratory uses Cursus, a dedicated software for haemovigilance. Benefits for using this software at different steps of the blood bank management are: simplification, security and harmonization of practices during receipt and issurance of blood components, securing recordings with the use of bar codes for patient identification and blood components listing, implementation of a computerized tracking system for transfusion, traceability, limitation of written documents and availability of statistics on the management of the depot. PMID: 18930679 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1895754 Fri, 17 Oct 2008 04:00:00 +0100 1895754 http://www.medworm.com/index.php?rid=1895753&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18930680%26dopt%3DAbstract Authors: Quaranta JF, Canivet N, Darmon MJ, Jambou P, Rocher F, Staccini P, Benzaken S, Paquis P The sanitary vigilances represent a permanent sanitary surveillance. They signal, enregister, treat and investigate the adverse events occurring through the use of health products. They assure the traceability of these health products and the management of the sanitary alerts. The sanitary vigilances are part of the sanitary security. They are optimized when coordinated and integrated to the global risk management process of the health care establishments. PMID: 18930680 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1895753 Fri, 17 Oct 2008 04:00:00 +0100 1895753 http://www.medworm.com/index.php?rid=1895752&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18930681%26dopt%3DAbstract Authors: Galperine IR, Galperine M PMID: 18930681 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1895752 Fri, 17 Oct 2008 04:00:00 +0100 1895752 http://www.medworm.com/index.php?rid=1895751&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18930682%26dopt%3DAbstract Authors: Raynal MJ In hospitals, patients' identity mismatch is the cause of serious incidents during transfusion or other healthcare processes. With a wider use of healthcare software, new dysfunctions and risks may occur in case of ID mismatch between different software and for transfusion between blood bank and hospital. Four critical stages are to be considered when using software management of hospital care: initial patients' identification, modifications of identification data during hospital stay and then synchronization of all different software, proper use of patient's identification means by hospital staff and share of patient's identification data with others such as the Etablissement français du sang (EFS) for transfusional purposes. Perpignan Hospital has put in place... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1895751 Fri, 17 Oct 2008 04:00:00 +0100 1895751 http://www.medworm.com/index.php?rid=1895750&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18930683%26dopt%3DAbstract We present this original and collective approach of assessing practices leading to offers that both respond to a legal framework and improve blood products flows without damaging transfusion security. PMID: 18930683 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1895750 Fri, 17 Oct 2008 04:00:00 +0100 1895750 http://www.medworm.com/index.php?rid=1895749&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18930684%26dopt%3DAbstract Authors: Levy G ABO-incompatible transfusions remain frequent in Europe despite the technological progresses in relation with the potential number of human errors during the control procedures of the transfusion chain. The agglutination bedside-test is only one step of this chain and the amelioration of the security will be achieved by its replacement by an electronical check. PMID: 18930684 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1895749 Fri, 17 Oct 2008 04:00:00 +0100 1895749 http://www.medworm.com/index.php?rid=1895748&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18930685%26dopt%3DAbstract Authors: Godard M, Forest A, Verny M, Boddaert J The frequency of anemia is responsible of a frequent use of transfusion in elderly patients. However, transfusion in elderly patients requires several warnings. First, semiology of elderly patients is characterized with atypical clinical signs, and anemia tolerance is often difficult to appreciate. Second, numerous comorbidities make of elderly patients an heterogeneous population, in which guidelines are poorly applicable. Last, elderly patients are particularly sensitive to iatrogenic events, and the haemodynamic overload related to transfusion has to be carefully managed. All these difficulties raise the need of prospective studies on transfusion in elderly patients to validate clinical practice. PMID: 18930685 [PubMed - as suppli... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1895748 Fri, 17 Oct 2008 04:00:00 +0100 1895748 http://www.medworm.com/index.php?rid=1895747&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18930686%26dopt%3DAbstract Authors: Legrand D Patients receiving blood transfusion must benefit from the same quality of care, no matter where they are treated. In an effort to enhance transfusion safety, regulations applicable to blood depot facilities have been considerably reinforced over the last few years. At the present time, facilities authorized to store and distribute labile blood products are subject to the same principles of good practice as transfusion centers. A series of regulations published in 2007 established the duties and responsibilities of depot facilities according to category (emergency, intermediary or distribution) and set out the conditions for certification. PMID: 18930686 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1895747 Fri, 17 Oct 2008 04:00:00 +0100 1895747 http://www.medworm.com/index.php?rid=1895746&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18930687%26dopt%3DAbstract Authors: Roussel P, Guez P, Moll MC Risk management is a major stake for healthcare organisations. In a systemic approach, the process is based on methods and tools, of which the main ones are mentioned, for general application by clinical or technical teams, for some of them with quality and risk management support. PMID: 18930687 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1895746 Fri, 17 Oct 2008 04:00:00 +0100 1895746 http://www.medworm.com/index.php?rid=1895745&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18930688%26dopt%3DAbstract This article presents an organisation using a follow-up by electronic temperature monitors to record the temperature during the transportation and storage processes. PMID: 18930688 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1895745 Fri, 17 Oct 2008 04:00:00 +0100 1895745 http://www.medworm.com/index.php?rid=1895744&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18930689%26dopt%3DAbstract Authors: Lassale B Blood transfusion is a medical act, which follows the dictates of important rules in medical responsability. The following presentation will mention the legal responsibility of the practitioner throughout the transfusion process: first, giving the patient complete and precise information and geting his full consent; then, writing the appropriate prescription; finally, balancing the benefice and risk of therapy and using reglementation to avoid the practitioner's responsibility to be put at risks. PMID: 18930689 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1895744 Fri, 17 Oct 2008 04:00:00 +0100 1895744 http://www.medworm.com/index.php?rid=1895743&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18930690%26dopt%3DAbstract Authors: Béchon C PMID: 18930690 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1895743 Fri, 17 Oct 2008 04:00:00 +0100 1895743 http://www.medworm.com/index.php?rid=1895762&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18930419%26dopt%3DAbstract Authors: Lassale B, Courtinat C The hospital risk management department is firstly involved in the methodological analysis of grade zero transfusion incidents. The system is based on a subsequent analysis process in compliance with the ongoing requirements of the Haute Autorité de santé (HAS) for a reactive approach to risk, allowing to identify failures and start the appropriate preventive and corrective measures. The use of the association of litigation and risk management method makes easier the grade zero analysis and brings to light the team or institutional, organizational, temporal, individual factors representative of undesirable effects. Two main factors come out again from this analysis, the absence of the identification bracelet coupled with a disrespect of transfu... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1895762 Thu, 16 Oct 2008 04:00:00 +0100 1895762 http://www.medworm.com/index.php?rid=1895761&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18930420%26dopt%3DAbstract Authors: Mertes PM, Baumann A, Audibert G In neurosurgery, the question of the optimal transfusion "trigger" remains a controversial matter. Regarding the brain, the current data are still incomplete, justifying the continuation of experimental and clinical studies. The existing expert advices are based on these rather poor data and would probably evolve after the completion of clinical studies in progress. In spine surgery, the situation is simpler and the transfusional stakes are quite similar to those of orthopedics and traumatology. With regard to hemostasis, standardized recommendations exist depending on the laboratory test results or the anticoagulant treatments of the patient. PMID: 18930420 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1895761 Thu, 16 Oct 2008 04:00:00 +0100 1895761 http://www.medworm.com/index.php?rid=1895760&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18930421%26dopt%3DAbstract Authors: Rosencher N, Bellamy L, Chabbouh T, Arnaout L, Ozier Y In addition to more restrictive "transfusion triggers", presently available allogeneic blood conservation strategies in surgery include preoperative increase in red blood cells (RBC) mass, techniques or pharmaceutical agents that reduce blood loss, and perioperative blood salvage. Because of very important risk reduction in allogeneic blood, benefit/risk of preautologous blood donation (PAD) is quite questionable at this moment. Indeed, at this moment in France, we focus to avoid any transfusion (allogeneic and autologous blood). Therefore the most important techniques used are pharmacological: erythropoietin before surgery with a number of injections related to baseline Hb, and tranexamic acid during and after surgery. Ce... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1895760 Thu, 16 Oct 2008 04:00:00 +0100 1895760 http://www.medworm.com/index.php?rid=1895759&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18930422%26dopt%3DAbstract Authors: Renaudier P In the field of oncohematology, the rationale for the use of blood transfusion relies both on the proliferative advantage of the transformed clone over the others and on hematologic toxicity of chemotherapy. In France, transfusion thresholds are established by a consensus conference organized by the Agence française de sécurité sanitaire des produits de santé (Afssaps), the French health products safety agency: 80g/l for PRC and 10G/l for platelets concentrates in patients without additional hemorragic risk factors. For FFP especially in TTP, thresholds are more patient-related. Transfusion for sickle cell patients remains a scientific challenge. PMID: 18930422 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1895759 Thu, 16 Oct 2008 04:00:00 +0100 1895759 http://www.medworm.com/index.php?rid=1895758&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18930423%26dopt%3DAbstract Authors: Ozier Y Uncontrolled hemorrhage is the most common cause of potentially preventable death in massive trauma. In addition to the early identification of potential bleeding sources and angiographic embolisation or surgical bleeding control, in-hospital management will aim at maintain tissue oxygenation with volume replacement using crystalloids, colloids and RBC. In general, RBC transfusion is recommended to maintain hemoglobin between 7-10g/dL. The complex combination of clotting factors and platelets consumption, loss and dilution, shock, hypothermia, acidosis and colloid-induced hemostatic alterations leads to coagulopathic bleeding. Most guidelines recommend the use of FFP in significant bleeding complicated by coagulopathy (PT, aPTT >1.5 times control). Platelets should ... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1895758 Thu, 16 Oct 2008 04:00:00 +0100 1895758 http://www.medworm.com/index.php?rid=1895757&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18930424%26dopt%3DAbstract This study was reviewed on three years of transfusion in France. The main objective of this study was to see if there was a difference in frequency when these PCs were in solution or not. All adverse reactions in recipients (ARR) occurring among PCs recipients (with and without additive solution) were analysed. The categories of ARR specifically studied were: allergies, febril non haemolytic reactions (FNHR) and the category "unknown". This study shows that there is significantly lower incidence of allergies by introducing solution. For all ARRs, there is also a decrease in their frequency when PCs are in additive solution, it is significant except for the apheresis platelet concentrates. For categories FNHR and "unknown", the results are opposed and/or not significant. This study confirms... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1895757 Thu, 16 Oct 2008 04:00:00 +0100 1895757 http://www.medworm.com/index.php?rid=1895756&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18930425%26dopt%3DAbstract Authors: Daurat G ABO incompatible transfusions are still a frequent cause of serious adverse transfusion reactions. Bedside check is intended to detect patient errors and prevent ABO mismatch. France is one of the few countries that includes ABO agglutination test for red blood cells in bedside checks. Evaluation of this ABO agglutination test, performed with a special card, shows that, on the field, despite frequent users' mishandling, it can detect up to 93% of ABO incompatibilities. This is not enough to rely on this sole test for bedside checks. But, linking it with an another test, currently, checks that the right blood is given to the right patient, rises the sensitivity of the whole bedside procedure up to an estimated 99.65%, for detection of ABO incompatibilities. This linkag... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1895756 Thu, 16 Oct 2008 04:00:00 +0100 1895756 http://www.medworm.com/index.php?rid=1888578&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18926755%26dopt%3DAbstract CONCLUSION: Evolution understanding of blood products distribution requires precisions about the kind of products and the hospitals status and specialties: medical, surgical, even obstetrical or urgency-related. The present trend is a rise for public hospitals and medical specialties, which are both the largest. Blood transfusion needs will thus go on rising in the years to come. PMID: 18926755 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1888578 Tue, 14 Oct 2008 04:00:00 +0100 1888578 http://www.medworm.com/index.php?rid=1888577&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18926756%26dopt%3DAbstract Authors: Desaint C PMID: 18926756 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1888577 Tue, 14 Oct 2008 04:00:00 +0100 1888577 http://www.medworm.com/index.php?rid=1883708&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18922721%26dopt%3DAbstract Authors: Rouger P It is necessary for European countries to have references and guidelines to cope with the wide field of blood transfusion. It is the institutions and professionals' role to provide for technical specifications linked to the collection, qualification, preparation, storage and distribution of labile blood products. In this context, EuroNet-TMS publishes every five year (2005, 2010...) a White Book meant to issue statements on the current situation, activities in progress in Europe and future developments. PMID: 18922721 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1883708 Mon, 13 Oct 2008 04:00:00 +0100 1883708 http://www.medworm.com/index.php?rid=1883707&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18922722%26dopt%3DAbstract Authors: Legrand D The Alps-Mediterranean division of the French blood establishment (EFS Alpes-Mediterranée) has implemented a risk management program. Within this framework, the labile blood product distribution process was assessed to identify critical steps. Subsequently, safety measures were instituted including computer-assisted decision support, detailed written instructions and control checks at each step. Failure of these measures to prevent an incident underlines the vulnerability of the process to the human factor. Indeed root cause analysis showed that the incident was due to underestimation of the danger by one individual. Elimination of this type of risk will require continuous training, testing and updating of personnel. Identification and reporting of nonconformiti... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1883707 Mon, 13 Oct 2008 04:00:00 +0100 1883707 http://www.medworm.com/index.php?rid=1883706&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18922723%26dopt%3DAbstract Authors: Galperine IR PMID: 18922723 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1883706 Mon, 13 Oct 2008 04:00:00 +0100 1883706 http://www.medworm.com/index.php?rid=1865835&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18842434%26dopt%3DAbstract CONCLUSION: A global approach to the risk of postoperative anemia but also of MAE related to postoperative haemorrage can be obtained by monitoring electronic databases. PMID: 18842434 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1865835 Mon, 06 Oct 2008 04:00:00 +0100 1865835 http://www.medworm.com/index.php?rid=1865834&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18842435%26dopt%3DAbstract Authors: Cognasse F, Hamzeh-Cognasse H, Garraud O Platelets are nonnucleated cellular elements that play a role in the process of haemostasis, and also in various ways in innate immunity and in inflammation. Platelets also contain numerous secretory products and can exert critical roles in several aspects of haemostasis. In addition, they house and secrete a variety of cytokines, chemokines and associated molecules which behave as ligands for receptors/counterparts displayed by endothelial cells lining tissue vessels and most leukocyte subsets. These latter studies show that platelets have an important role in innate as well as adaptive immunity; thus platelets can take part in an immune directive response. Moreover, platelets display receptors for several types of cytokines/chemokines... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1865834 Mon, 06 Oct 2008 04:00:00 +0100 1865834 http://www.medworm.com/index.php?rid=1794826&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18789743%26dopt%3DAbstract We report a new case of anti-Xg(a) antibody found in a man who, after receiving six units of standard red blood cells, developed a minor nonhemolytic transfusion reaction (chills-hyperthermia). The patient sera was used for an immunophenotyping scale in 777 healthy Tunisian blood donors (678 men; 99 women). The phenotype frequencies of Xg(a+) and Xg(a-) were 67.4% and 32.6% in men and 89 and 11% in women, respectively. The gene frequencies of Xg(a) and Xg were 0.67 and 0.33, respectively. These frequencies are similar to that reported in predominantly white populations. PMID: 18789743 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1794826 Wed, 10 Sep 2008 04:00:00 +0100 1794826 http://www.medworm.com/index.php?rid=1794825&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18789744%26dopt%3DAbstract Authors: Courbil R, Chenus F, Julien H, Ruyer-Dumontier P, Garraud O Blood donation requires a partnership for its organization between Etablissement français du sang and associations. A partnership guide, conceived by and for the operations team in the first rank of which Associations for Altruistic Blood Donation, was worked out to remind or inform conditions necessary for the good sequence of a blood donation. Through this guide, the authors also wanted to clarify the role and the responsibilities of each partner for a better reception of the Candidate for donation. The elaboration of this guide is only a first stage towards an homogenization or even an overhaul of the organization of blood donation. PMID: 18789744 [PubMed - as supplied by publisher] (Source: Transfusion Cl... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1794825 Wed, 10 Sep 2008 04:00:00 +0100 1794825 http://www.medworm.com/index.php?rid=1755344&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18757223%26dopt%3DAbstract CONCLUSION: Blood group A may be associated with early-onset ovarian hyperstimulation syndrome in Caucasians. Depending on further studies, this possible association may be considered for an individualized hormone dosing in controlled ovarian stimulation. PMID: 18757223 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1755344 Fri, 29 Aug 2008 04:00:00 +0100 1755344 http://www.medworm.com/index.php?rid=1755343&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18757224%26dopt%3DAbstract CONCLUSIONS: RBC transfused in our ICU are old. The ICU outcome is independently associated with the number of leucodepleted RBC transfused, but not with their age. PMID: 18757224 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1755343 Fri, 29 Aug 2008 04:00:00 +0100 1755343 http://www.medworm.com/index.php?rid=1755342&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18760949%26dopt%3DAbstract CONCLUSION: - Preparation and storage procedure adopted in our centre did not significantly affect the quality SPC. Our study is the first to assess the PLA in PC. Studies assessing the PLA are warranted to appreciate the clinical impact of this parameter. PMID: 18760949 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1755342 Thu, 28 Aug 2008 04:00:00 +0100 1755342 http://www.medworm.com/index.php?rid=1631753&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18620885%26dopt%3DAbstract Authors: Garraud O, Pelletier B, Aznar C Various infectious agents can be transmitted by blood exposure, which comprises of transfusion, of which hemoparasites that are commonly absent from European countries but that can have infected blood donor candidates born, raised or having been living in the Tropics. Among those hemoparasites is Trypanosoma cruzi, responsible for Chagas disease. T. cruzi is responsible for acute post-transfusion infections every year in endemic areas (South America) and also, more incidently, in North America. There are situations which expose European blood donors to this risk and the present essay discusses arguments which have now been taken into consideration by certain transfusion systems such as the French one. PMID: 18620885 [PubMed - as supplied by ... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1631753 Thu, 10 Jul 2008 04:00:00 +0100 1631753 http://www.medworm.com/index.php?rid=1631754&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18619889%26dopt%3DAbstract Authors: Ben Nasr M, Jenhani F Apoptosis represents a particular form of programmed cell death which appears in all the damaged cells and potentially hazardous. It plays a crucial role in the development of multicellular organisms by assuring and maintaining the cellular homeostasis. Thus, apoptosis intervenes not only in the normal process of organisms' development but also in immune defence and in cancerous cells detection. Indeed, any blockage in the program of the apoptotic machinery would be responsible of some neurodegenerative and auto-immune diseases and could play a crucial role in different steps of carcinogenesis. Some researchers were very interested in studying apoptosis in hematopoietic stem cells CD34+ which could be intended to be reinfused to patients suffering from ma... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1631754 Wed, 09 Jul 2008 04:00:00 +0100 1631754 http://www.medworm.com/index.php?rid=1509364&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18538607%26dopt%3DAbstract Authors: Martinière K, Lucas S, Zorzi P Biovigilance is defined as the surveillance of therapeutic use in man of organs, tissues and cells. Four years after the implementation of the French biovigilance system, a first analysis of data collected has been performed by Afssaps. Quantitatively, with the exception of 2004, the first year of implementation, the average number of annual notifications reaches 166. Taking into account the total number of human applications, it has to be noted that events and adverse reactions notified and involving tissues are rather low compared to those involving organs and cells. From a qualitative point of view, this analysis allows to identify different categories of events and adverse reactions with the corresponding number of notifications for each... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1509364 Wed, 04 Jun 2008 04:00:00 +0100 1509364 http://www.medworm.com/index.php?rid=1509363&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18538608%26dopt%3DAbstract Authors: Burnouf T, Goubran HA, Radosevich M, El-Ekiaby M Non-virally inactivated plasma, cryoprecipitate and cryoprecipitate-poor plasma, prepared by blood establishments, are still used in many countries in the world, in both the developing world and industrialized countries, for the treatment of various hematological disorders. In the absence of viral inactivation treatment, these fractions may be involved, in spite of increasingly sensitive viral detection methods, into the transmission of plasma-borne viruses, most critically HIV and Hepatitis B (HBV) or C (HCV). We have adapted the well-established industrial solvent-detergent (SD) viral inactivation treatment to allow its application in a small scale using a single-use plastic bag system. The procedure can be used by blood estab... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1509363 Wed, 04 Jun 2008 04:00:00 +0100 1509363 http://www.medworm.com/index.php?rid=1497885&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18524660%26dopt%3DAbstract Authors: Saas P, Bonnefoy F, Kleinclauss F, Sun Y, Tiberghien P, Gaugler B, Perruche S In the past few years, significant advances have been performed in the field of cell-based therapies. This concerns mainly regenerative medicine with the use of stem cells, as well as the modulation of immune responses. In order to modulate allogeneic immune responses after transplantation, we have developed a cell therapy approach based on the immunomodulatory properties of intravenous donor apoptotic cell infusion. In allogeneic hematopoietic cell transplantation settings, we reported that intravenous apoptotic leukocyte infusion, simultaneously to allogeneic bone marrow grafts, favors hematopoietic engraftment, prevents alloimmunization and delays graft-versus-host disease. Here, we review the dif... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1497885 Mon, 02 Jun 2008 04:00:00 +0100 1497885 http://www.medworm.com/index.php?rid=1497884&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18524661%26dopt%3DAbstract CONCLUSION: Our QC data show an overall compliance with the requirements for cellular BC. Our data bank is useful to inform on the performance of leucoreduced BC preparation processes carried out with market available devices. PMID: 18524661 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1497884 Mon, 02 Jun 2008 04:00:00 +0100 1497884 http://www.medworm.com/index.php?rid=1488890&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18515167%26dopt%3DAbstract Authors: Cartron JP, Elion J In sickle cell disease, the complex scenario of vaso-occlusive crisis (VOC) typical of this disease is clearly multifactorial and not fully understood. Cell-cell and cell-cell matrix interactions mediated by adhesive molecules present on blood cells and endothelial cells (ECs) are thought to play an important role. Early studies have shown that sickle red blood cells (RBCs) are abnormally adherent to ECs and some of the molecules involved in these interactions have been identified, such as the alpha4beta1 integrin and CD36, exclusively present on stress reticulocytes, and CD47 on mature RBCs. More recently, attention focused on Lu/BCAM, the unique RBC receptor for laminin, and on ICAM-4, a red cell-specific adhesion receptor, which is a ligand for a large r... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1488890 Fri, 30 May 2008 04:00:00 +0100 1488890 http://www.medworm.com/index.php?rid=1488891&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18514562%26dopt%3DAbstract Authors: Mercereau-Puijalon O, Guillotte M, Vigan-Womas I The capacity of Plasmodium falciparum-infected red blood cells to bind uninfected red blood cells ("rosetting") has been associated with high parasite density in numerous geographic areas and with severe malaria in African children. We summarize here the associations that have emerged from field studies and describe the various experimental models of rosetting that have been developed. A variety of erythrocyte receptors, several serum factors and a number of rosette-mediating PfEMP1 adhesins have been identified. Several var genes code for rosette-forming PfEMP1 adhesins in each P. falciparum genome, so that each clonal line has the capacity to generate distinct types of rosettes. To clarify their respective role in malaria path... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1488891 Thu, 29 May 2008 04:00:00 +0100 1488891 http://www.medworm.com/index.php?rid=1488892&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18514010%26dopt%3DAbstract Authors: El Nemer W, Gauthier E, Wautier MP, Rahuel C, Gane P, Galactéros F, Wautier JL, Cartron JP, Colin Y, Le Van Kim C Lutheran (Lu) blood group and Basal Cell Adhesion Molecule (BCAM) antigens are both carried by two glycoprotein (gp) isoforms of the immunoglobulin superfamily representing receptors for laminin alpha(5) chain. They are expressed in red blood cells, in endothelial cells of vascular capillaries and in epithelial cells of several tissues. Lu/BCAM gps are overexpressed in sickle red blood cells (SS RBCs). Stimulation of SS RBCs by epinephrine activates the PKA depending signaling pathway and induces reinforced Lu/BCAM-mediated adhesion to laminin10/11. We have analyzed the phosphorylation state of Lu/BCAM long isoform cytoplasmic tail and showed that it is phosph... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1488892 Wed, 28 May 2008 04:00:00 +0100 1488892 http://www.medworm.com/index.php?rid=1470187&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18502676%26dopt%3DAbstract Authors: Zennadi R, De Castro L, Eyler C, Xu K, Ko M, Telen MJ Erythrocytes containing primarily hemoglobin S (SS RBCs) are abnormally adherent. We now know that SS RBCs express numerous adhesion molecules, and that many of these can undergo activation. SS RBCs exposed briefly to epinephrine show markedly increased adhesion to both laminin and endothelial cells. In vivo, infusion of epinephrine-activated but not unstimulated SS RBCs causes RBC adhesion, vaso-occlusion, organ trapping, and shortened RBC survival in the circulation. Epinephrine treatment of SS RBCs before infusion also induces adhesion of murine leukocytes to vascular walls. Indeed, in vitro, SS RBCs can activate leukocyte adhesion and cytokine production. We now have demonstrated both in vitro and in vivo evidence for t... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1470187 Fri, 23 May 2008 04:00:00 +0100 1470187 http://www.medworm.com/index.php?rid=1470186&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18502677%26dopt%3DAbstract Authors: Beuzard Y In the absence of a natural animal model for sickle cell disease, transgenic mouse models have been generated to better understand the complex pathophysiology of the disease and to evaluate potential specific therapies. In the early nineties, the simple addition of human globin genes induced the expression of hemoglobin S (HbS) or HbS-related human hemoglobins in mice still expressing mouse hemoglobin. To increase the proportion of human hemoglobin and the severity of the mouse sickle cell syndrome, the proportion of mouse hemoglobin could be decreased by a combination of mouse alpha- and beta-thalassemic defects, leading to complex genotypes and mild disease. Following the discovery of gene targeting in the mouse embryonic stem cells (ES cells), it was made possible... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1470186 Fri, 23 May 2008 04:00:00 +0100 1470186 http://www.medworm.com/index.php?rid=1470192&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18501652%26dopt%3DAbstract Authors: Hebbel RP Sickle RBC are abnormally adherent to vascular endothelial cells. We briefly review the mechanisms that underlie this type of cell/cell adhesion, expose a number of extant myths about RBC adhesion, and discuss some aspects that need consideration via future experimentation. The relationship of this phenomenon of RBC-endothelial adhesion to the cytoadherence of parasitized sickle RBC is not yet clear. PMID: 18501652 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1470192 Wed, 21 May 2008 04:00:00 +0100 1470192 http://www.medworm.com/index.php?rid=1470191&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18501653%26dopt%3DAbstract Authors: Tilley L, Hanssen E The most deadly of the human malaria parasites, Plasmodium falciparum, invades the erythrocytes of its host and initiates a remarkable series of morphological rearrangements within the host cell cytoplasm. The mature erythrocyte is effectively a floating sack of haemoglobin with no endogenous protein synthesis or protein trafficking machinery. In order to colonise and remodel its extracellular space, the parasite generates a series of novel structures that are involved in the export of virulence factors to the surface of the host cell. These include extensions of the parasite's vacuolar membrane, known as the tubulovesicular network, and structures referred to as Maurer's clefts. Maurer's clefts are convoluted collections of distorted discs that are tethere... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1470191 Wed, 21 May 2008 04:00:00 +0100 1470191 http://www.medworm.com/index.php?rid=1470190&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18501654%26dopt%3DAbstract Authors: Dondorp AM Reduced microcirculatory flow is a fundamental feature in the pathophysiology of severe Plasmodium falciparum malaria and sequestration of red blood cells containing mature parasites is considered a central cause of this. Direct microscopic observation of the microcirculation in the living patient with severe malaria has enabled us to quantify this phenomenon and link it to severity of disease, supporting the findings of pathology studies. Moreover, the sequestered parasite biomass, calculated from parasite derived plasma PfHRP2 concentrations, strongly correlates with disease severity. Artesunate prevents sequestration by killing ring form parasites, aborting their maturation, which can explain the mortality benefit of this drug compared to quinine in the treatment... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1470190 Wed, 21 May 2008 04:00:00 +0100 1470190 http://www.medworm.com/index.php?rid=1470189&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18501655%26dopt%3DAbstract Authors: van Buul JD, Hordijk PL Leukocyte transendothelial migration is controlled by chemokine-induced signalling in leukocytes and integrin-ligand-induced bidirectional signalling in both leukocytes and endothelial cells. It is now generally accepted that endothelial signalling following leukocyte adhesion, serves to facilitate the crossing of the endothelium, be it via the paracellular or transcellular route. This brief overview discusses the main findings within this area and highlights some recent findings that shed new light on adhesion-induced signalling in the context of leukocyte transendothelial migration. PMID: 18501655 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1470189 Wed, 21 May 2008 04:00:00 +0100 1470189 http://www.medworm.com/index.php?rid=1470188&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18501656%26dopt%3DAbstract Authors: Brittain JE, Parise LV The alpha4beta1 integrin is an adhesion receptor expressed on reticulocytes in sickle cell disease (SCD) and mediates the adhesion of these cells to sub-endothelial matrix proteins and the endothelium. In this review, we describe the mechanism of activation of the alpha4beta1 integrin on sickle reticulocytes and discuss novel roles for this integrin in SCD as a result of this activation. We also illustrate novel therapies in SCD that may target the integrin and alleviate vaso-occlusion. PMID: 18501656 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1470188 Wed, 21 May 2008 04:00:00 +0100 1470188 http://www.medworm.com/index.php?rid=1466341&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18499496%26dopt%3DAbstract Authors: de Montalembert M Hydoxyurea is the unique drug having demonstrated an efficacy in preventing recurrences of painful crises, acute chest syndromes and in reducing transfusional needs in patients severely affected with sickle cell disease. However, there is a wide variation in the clinical response to hydroxyurea in sickle cell patients, with children generally experiencing greater benefits than adults. Short- and middle-term tolerances are good. Our uncertainties about long-term tolerance are mainly that we do not know the consequences of the drug on ulterior fertility in boys treated early and for long periods. Hydroxyurea has just been licensed for sickle cell adults and children in Europe. Its prescription for the moment must be restricted to severely affected patients, enr... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1466341 Tue, 20 May 2008 04:00:00 +0100 1466341 http://www.medworm.com/index.php?rid=1466340&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18499497%26dopt%3DAbstract Transfus Clin Biol. 2008 May 20; Authors: Tsai R, Rodriguez P, Discher DE A method is being developed to study cytoskeletal reorganization in cell adhesion processes. The initial model process is adhesion and phagocytosis of beads or red blood cells by macrophages. Live cell labeling with Cys reactive fluorophores is performed before and during phagocytosis with different color labeling dyes. Since Cys is a relatively hydrophobic amino acid, its differential exposure and labeling in principle reflects changes in tertiary or quaternary structure of specific proteins. Similar studies conducted on red blood cells under fluid shear conditions showed that specific domains in spectrin undergo extensible unfolding within sheared cells. The initial work here with macrophages also suggests ... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1466340 Tue, 20 May 2008 04:00:00 +0100 1466340 http://www.medworm.com/index.php?rid=1466339&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18499498%26dopt%3DAbstract Authors: Cartron JP, Milon G PMID: 18499498 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1466339 Tue, 20 May 2008 04:00:00 +0100 1466339 http://www.medworm.com/index.php?rid=1464328&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18495515%26dopt%3DAbstract Authors: Higgins JM, Eddington DT, Bhatia SN, Mahadevan L Vaso-occlusive events are responsible for the majority of morbidity and mortality in sickle cell disease. Predisposing conditions are unclear, and proximal causes have not been established. Despite decades of intense study, until recently there has not been a well-controlled in vitro model of sickle cell vaso-occlusion. We have reported the development and initial use of such a model. Our experimental device relies on microfluidic technology and has allowed the initial analysis of the in vitro process of vaso-occlusion in terms of control parameters such as driving pressure, local oxygen concentration and flow vessel size. Our work demonstrates the potential of this type of device to lead to greater understanding of vaso-occlusi... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1464328 Mon, 19 May 2008 04:00:00 +0100 1464328 http://www.medworm.com/index.php?rid=1464327&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18495516%26dopt%3DAbstract Authors: Kaul DK Among multiple pathologies associated with sickle cell disease, sickle red cell-endothelial interaction has been implicated as a potential initiating mechanism in vaso-occlusive events that characterize this disease. Vast literature exists on various aspects of sickle red cell adhesion, but many issues remain unresolved, especially pertaining to the role of sickle red cell heterogeneity, the relative role of multiple adhesion mechanisms and targets of antiadhesive therapy. This review briefly analyzes these issues. PMID: 18495516 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1464327 Mon, 19 May 2008 04:00:00 +0100 1464327 http://www.medworm.com/index.php?rid=1401548&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18436463%26dopt%3DAbstract Authors: Daniels G, Finning K, Martin P, Summers J The most important application of blood group genotyping by molecular genetics is the prediction of fetal RhD phenotype in pregnant women with anti-D, in order to assess the risk of haemolytic disease of the fetus and newborn. This diagnostic test performed on cell-free fetal DNA in the maternal plasma, is now a routine procedure in some countries. High-throughput modifications of this form of fetal D-typing would be valuable for testing fetuses of all D-negative pregnant women to avoid unnecessary antenatal treatment with anti-D immunoglobulin in the 40% of D-negative pregnant women with a D-negative fetus. The results of trials in Bristol and Amsterdam suggest that such routine testing is feasible and accurate. PMID: 18436463 [Pu... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1401548 Tue, 22 Apr 2008 04:00:00 +0100 1401548 http://www.medworm.com/index.php?rid=1399463&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18434227%26dopt%3DAbstract Authors: Cabibbo S, Fidone C, Antolino A, Manenti OG, Garozzo G, Travali S, Bennardello F, Di Stefano R, Bonomo P The treatment of thalassemia is still essentially based on continuous transfusion supporting using red cell concentrates (RCC) prepared in different ways. For patients with sickle-cell disorders, either urgent or chronic red blood cell transfusion therapy, is widely used in the management of sickle cell disease (SCD) because it reduces HbS level and generally prevents recurrent vaso-occlusive disease (VOD). Recently, the introduction of prestorage filtration to remove leukocytes and the use of techniques for multicomponent donation have increased the types of blood components available for transfusion purposes. The clinical effects of different types of blood components in ... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1399463 Mon, 21 Apr 2008 04:00:00 +0100 1399463 http://www.medworm.com/index.php?rid=1396497&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18430601%26dopt%3DAbstract Authors: Pirie L, McClelland DB, Franklin IM, The EU optimal blood use project (EUOBUP) is cofunded by the European Commission and led by the Scottish National Blood Transfusion Service (SNBTS). Its purpose is to develop, evaluate and disseminate a manual that provides practical guidance and support for those seeking to improve the safety of the clinical transfusion process and the effectiveness of the prescribing of blood components. We define the optimal use of blood components as the safe, clinically effective and efficient use of the scarce resource of donated human blood. The project will build on the experience of a pilot project in optimal use of blood in the national health service in Scotland. This pilot developed training resources in the safe and effective use of blood and ... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1396497 Fri, 18 Apr 2008 04:00:00 +0100 1396497 http://www.medworm.com/index.php?rid=1396496&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18430602%26dopt%3DAbstract Authors: Stanworth SJ, Hyde CJ, Murphy MF There continues to be a general but unfounded enthusiasm for fresh frozen plasma (FFP) usage across a range of clinical specialties in hospital practice. Clinical use of plasma has grown steadily over the last two decades in many countries. In England and Wales, there has not been a significant reduction in the use of FFP over the last few years, unlike red cells. There is also evidence of variation in usage among countries - use in England and Wales may be proportionately less per patient than current levels of usage in other European countries and the United States. Plasma for transfusion is most often used where there is abnormal coagulation screening tests, either therapeutically in the face of bleeding, or prophylactically in non-bleeding ... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1396496 Fri, 18 Apr 2008 04:00:00 +0100 1396496 http://www.medworm.com/index.php?rid=1391389&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18424148%26dopt%3DAbstract Authors: Dietrich W The risk of transfusion of allogeneic blood products on outcome is well documented. Autologous blood donation prior to elective cardiac surgery has repeatedly shown to be an effective practice to reduce the exposure to allogeneic blood, but was criticized because of the alleged high costs. We analyzed the data of 4878 patients undergoing elective open-heart surgery, in whom 18% underwent autologous donation. Overall, autologous blood donation reduced the incidence of allogeneic blood transfusion from 48 to 13% during hospitalization. Additionally, it is shown that diagnosis adjusted autologous blood donation is cost-effective. The higher the probability of transfusion the better is efficacy and cost-effectiveness of predonation. Cardiac surgery is a high-transfusion... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1391389 Thu, 17 Apr 2008 04:00:00 +0100 1391389 http://www.medworm.com/index.php?rid=1387024&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18420438%26dopt%3DAbstract Authors: Rouger P Labile blood products are still here to stay for quite a long time. All European surveys come in agreement to reveal that indications, extremely heterogeneous from one country to another, are not fully under control. Both the EuroNet-TMS network and Euro'SAT congresses aim at improving the use of such products within an evidence-based medicine perspective. PMID: 18420438 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1387024 Tue, 15 Apr 2008 04:00:00 +0100 1387024 http://www.medworm.com/index.php?rid=1387023&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18420439%26dopt%3DAbstract Authors: van der Meer PF Platelet additive solutions (PASs) were first developed in the 1980s, and continued to be improved over the following years. The use of PASs as replacement for plasma has a number of benefits, both for the quality of the platelet concentrates and for the patients. However, some PASs have been associated with a lower platelet yield in the PCs, a shorter storage time, and a lower increment in the patient when compared to PCs in plasma. A number of reformulations of the PASs have taken place to counteract these disadvantages. Most PASs use acetate as nutrient for the platelets, which has the benefit of generating bicarbonate when oxidized by the platelets, thus supplying its own buffering capacity. Alternatively, glucose is used, but may cause deterioration of pH ... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1387023 Tue, 15 Apr 2008 04:00:00 +0100 1387023 http://www.medworm.com/index.php?rid=1382684&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18417400%26dopt%3DAbstract Authors: Lozano M, Cid J Platelet transfusion is about to commemorate its 50th year since its introduction in therapeutics. It is then surprising to see, that in spite of reaching this respectful age, we have not been able to definitely establish all the aspects related to its clinical use. Some of these facets are platelet transfusion threshold and the platelet dose to administer. Historically, two different transfusion triggers have been used for prophylactic and therapeutic platelet transfusions. For prophylactic platelet transfusion an increasing body of evidences suggests that a transfusion trigger of 10x10(9) per liter is appropriate for most clinical settings. In contrast, evidence for supporting a certain therapeutic transfusion trigger is lacking. Nevertheless, there is consen... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1382684 Mon, 14 Apr 2008 04:00:00 +0100 1382684 http://www.medworm.com/index.php?rid=1382683&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18417401%26dopt%3DAbstract Authors: Andreu G, Vasse J, Sandid I, Tardivel R, Semana G The respective use of random (RPC) and apheresis (APC) platelet concentrates is highly heterogeneous among countries, ranging from 10 to 98% RPC in countries supposed to provide a similar transfusion service to patients. Moreover, when considering each country in the past 10 years, one can observe that some have changed their policy, switching from a majority of APC to RPC or vice versa. This presentation intends to analyse which factors may impact such decisions. For many years, the only available platelet component was a RPC obtained from whole blood donation by a two centrifugation steps process, the "platelet rich plasma" or PRP method. Since the beginning of the 1970s, APCs became available, with in fact many different tec... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1382683 Mon, 14 Apr 2008 04:00:00 +0100 1382683 http://www.medworm.com/index.php?rid=1382682&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18417402%26dopt%3DAbstract We present the initial result of an ongoing survey addressed by the Madrid Blood Transfusion Centre. Based on the criteria of total amount of RBC transfused per year, large hospitals (more than 10,000 units of RBC) transfused an average of 23.87% of FFP, while medium hospitals (5000-10,000 units of RBC) used 19.5% and small ones (less than 5000) about 12.5%. It is important to point out that inside each group there were some important differences in ratio values for similar hospitals. This could indicate that much more is necessary to cope with indications. Although national figures of uses of FFP, whether in ratio or absolute terms, show a moderate consumption in comparison with published figures of other European countries, there can be no doubt that plasma overuses still seem to be pres... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1382682 Mon, 14 Apr 2008 04:00:00 +0100 1382682 http://www.medworm.com/index.php?rid=1373950&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18407773%26dopt%3DAbstract Authors: Benhamou D After a more than four-fold decrease in Fresh Frozen Plasma (FFP) consumption in the nineties in France, probably due to the consequences of HIV epidemics, the use of FFP is again increasing in recent years but at a slower rate. In the surgical and trauma area, recent data suggest that guidelines for the use of FFP may need to be modified. Indeed, contrary to traditional beliefs and guidelines, several studies evaluating conditions with severe hemorrhage (very often associated with coagulation abnormalities) have shown that early use of FFP may be associated with better patient outcome. This has indeed been shown in emergency major vascular surgery and in trauma patients. Although there is a trend to favor a larger use of FFP in specific circumstances (i.e., major h... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1373950 Fri, 11 Apr 2008 04:00:00 +0100 1373950 http://www.medworm.com/index.php?rid=1373949&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18407774%26dopt%3DAbstract Authors: Norda R, Tynell E The use of plasma in Sweden is relatively high compared to other countries in the European Union. An analysis of all transfusion recipients in Orebro county during the whole year 2000 was performed. There were 3159 transfusion recipients of whom 96% had a registered diagnosis and 50% had undergone a "true" operation. Seven hundred and eleven patients (23%) had received plasma. Significantly more operated than nonoperated and more men than women received plasma. The typical plasma recipient was a man undergoing cardiovascular surgery. In Sweden there are two main types of plasma components: fresh frozen (FFP) and nonfrozen liquid plasma stored for up to 14 days, both considered to be clinically equal for most indications. The quality of these components as wel... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1373949 Fri, 11 Apr 2008 04:00:00 +0100 1373949 http://www.medworm.com/index.php?rid=1368540&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18403227%26dopt%3DAbstract Authors: Peyrard T, Pham BN, Le Pennec PY, Rouger P A rare blood group is usually defined as the absence of a high prevalence antigen or the absence of several antigens within a single blood group system, if its prevalence in France is 4/1000 or less in the general population. An individual with a rare blood phenotype can develop a naturally-occurring or immune antibody corresponding to his rare specificity. In case an extremely low stock of compatible blood is available at the national level, a so-called "transfusion deadlock" is described. Most of the individuals with a rare blood group are coincidently identified when a routine pretransfusion testing or pregnancy follow-up is performed, if the antibody(ies) corresponding to the rare specificity is(are) present. Other individuals are... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1368540 Tue, 08 Apr 2008 04:00:00 +0100 1368540 http://www.medworm.com/index.php?rid=1341090&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18375165%26dopt%3DAbstract Transfus Clin Biol. 2008 Mar 27; Authors: Rouillac-Le Sciellour C, Sérazin V, Brossard Y, Oudin O, Le Van Kim C, Colin Y, Guidicelli Y, Menu M, Cartron JP Fetal RHD genotyping from maternal plasma was performed by real-time PCR amplification of exons 7 and 10 of the RHD gene and the amplified products were detected either with SYBR Green I dye according to our previously published method [Mol Diagn 8 (2004) 23-31] or with hydrolysis probes in a new Free DNA Fetal Kit RhD((R)). Plasma specimen from 300 RhD-negative pregnant women (between 10 to 34 weeks of gestation) were analysed and validation of the results was ascertained either by RHD genotyping on amniotic cells or by blood typing of the neonate at birth. We found 100% concordant results when comparing the two methods. Tw... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1341090 Thu, 27 Mar 2008 04:00:00 +0100 1341090 http://www.medworm.com/index.php?rid=1325592&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18359655%26dopt%3DAbstract Authors: Lienhart A The context of transfusion has changed in recent years. Some data could lead to an increased demand: the risk of viral transmission has significantly decreased; a national survey has revealed that the mortality related to an insufficient or delayed transfusion was higher to the side effects of the transfusion itself. Some other data could decrease the demand: the preoperative use of EPO is now easier; the intraoperative use of antifibrinolytic has been shown to be efficient. The number of allogenic red blood cells units (RBCs) transfused each year in France regularly increases, while the transfusion of predeposited autologous blood is in sharp decline. However, in hospitals still using but reducing this technique, the consumption of allogenic RBCs does not increase ... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1325592 Fri, 21 Mar 2008 04:00:00 +0100 1325592 http://www.medworm.com/index.php?rid=1325591&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18359656%26dopt%3DAbstract Authors: Novotny VM Many side-effects of red blood cell transfusion have been described. They include iron-overload, as well as allo- and autoantibody formation against red cells. During storage, erythrocytes undergo complex structural and biochemical changes. It has been suggested that accelerated and/or aberrant forms of the physiological erythrocyte aging process underlie the red cell storage lesion. This storage lesion may contribute to side-effects of transfusion as endothelial damage by release of internal erythrocyte constituents, (pro)inflammatory consequences, hampered microcirculation and oxygen delivery. Understanding the process that determines the fate of red blood cells after transfusion may contribute to the prevention of side-effects after red blood cell transfusion. Th... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1325591 Fri, 21 Mar 2008 04:00:00 +0100 1325591 http://www.medworm.com/index.php?rid=1325590&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18359657%26dopt%3DAbstract Authors: Desmond M Red cell salvage (RCS) is now an established therapy for patients undergoing surgery with an associated risk of heavy bleeding. It should always be available for such patients. It is, however, only one part of what should be a multifaceted approach to blood conservation and it does not replace the need for good quality surgical haemostasis. PMID: 18359657 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1325590 Fri, 21 Mar 2008 04:00:00 +0100 1325590 http://www.medworm.com/index.php?rid=1325589&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18359658%26dopt%3DAbstract The objective of this national audit was to examine the use of platelet transfusions against audit standards developed from national guidelines. Hospitals were asked to provide data on 40 consecutive patients receiving platelet transfusions (15 haematology patients, 10 cardiac, 10 critical care and five in other clinical specialties). One hundred and eighty-seven UK hospitals participated, including 168/263 (64%) hospitals in England. A total of 4421 patients receiving platelet transfusions were audited. The reason for transfusion was documented in the medical records for 93% of transfusions and 57% were used for prophylaxis (in the absence of bleeding). Overall 3726/4421 (84%) of the transfusions were evaluable and 43% (1601/3726) were found to be non-compliant with the audit standards. A... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1325589 Fri, 21 Mar 2008 04:00:00 +0100 1325589 http://www.medworm.com/index.php?rid=1278481&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18314367%26dopt%3DAbstract Authors: Cartron JP, Rouger P PMID: 18314367 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1278481 Fri, 29 Feb 2008 05:00:00 +0100 1278481 http://www.medworm.com/index.php?rid=1278482&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18313345%26dopt%3DAbstract CONCLUSION: In this study, the incidence of the complications for blood donation remains lower. The best choice of the donors by the doctor, taking into consideration the factors involved in these complications, reduces this incidence. PMID: 18313345 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1278482 Wed, 27 Feb 2008 05:00:00 +0100 1278482 http://www.medworm.com/index.php?rid=1258865&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18296094%26dopt%3DAbstract CONCLUSION: The results obtained confirm the negroïd character of guinean population. PMID: 18296094 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique) Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1258865 Fri, 22 Feb 2008 05:00:00 +0100 1258865 http://www.medworm.com/index.php?rid=1258864&cid=s_36126_19_f&fid=36126&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18296095%26dopt%3DAbstract Authors: Tayou Tagny C, Mbanya D, Garraud O, Lefrère JJ Malaria is a principal cause of mortality in Africa and represents a major blood-borne disease. The studies made on the continent show that transfusion-associated malaria is highly prevalent in blood donors groups and that some risk factors and clinical manifestations are frequently observed. The disease is mostly asymptomatic and the signs are mild, which reduces significantly an efficient selection of the blood donors during the predonation interview and a secure supply of blood products. Furthermore, the lack of appropriate screening assays of the malaria in blood banks on the continent limit the diagnosis of the disease and hamper the blood safety. However, the prevention of transfusion-associated malaria is a frequently ... Transfusion Clinique et Biologique journals http://www.medworm.com/rss/comments.php?id=1258864 Fri, 22 Feb 2008 05:00:00 +0100 1258864