MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Transfusion Medicine' source. Wed, 08 Feb 2012 17:42:14 +0100 http://www.medworm.com/index.php?rid=5553047&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2011.01128.x Conclusion: A subgroup of younger age donors was found to have no known risk factor. To develop better screening strategy, it is recommended that a more detailed analysis of this group of donors is required. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=5553047 Fri, 30 Dec 2011 05:00:00 +0100 5553047 http://www.medworm.com/index.php?rid=5553046&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2011.01129.x The RHD gene is highly polymorphic and the existence of a large number of alleles results in RhD variant phenotypes. RHD genotyping has been used to distinguish normal D antigen from D variants due to limitations of serologic methods. The purpose of this study was to determine the phenotypic frequency of RhD and RhCE antigens and to investigate the RHD alleles present in samples with the weak D or D− phenotypes from Brazilian blood donors. A total of 2007 donors were phenotyped for D, C, c, E and e antigens. Samples phenotyped as D− were genotyped by polymerase chain reaction‐sequence specific primers, and exon 10 and intron 4 of the RHD gene were analysed. D− samples containing the RHD gene or samples considered weak D were further characterised using genotyping platform or nucleo... Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=5553046 Fri, 30 Dec 2011 05:00:00 +0100 5553046 http://www.medworm.com/index.php?rid=5506088&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2011.01123.x Conclusion: We have shown that the thrombin clotting time test can be modified and used as a cheap and reliable marker for heparin contamination. We have successfully incorporated this modified test into our hospital's obstetric QC scheme. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=5506088 Fri, 16 Dec 2011 05:00:00 +0100 5506088 http://www.medworm.com/index.php?rid=5477390&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2011.01121.x Conclusion: Malaria parasites carriage is frequent among blood donors in Yaoundé. These data seem to describe high‐risk donor profile and may help improving blood safety related to transfusion‐transmitted malaria in Cameroon. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=5477390 Mon, 05 Dec 2011 05:00:00 +0100 5477390 http://www.medworm.com/index.php?rid=5469780&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2011.01119.x Conclusions: By simple monitoring, donors who may be at increased risk from the apheresis procedure can be identified. By performing pre‐donation pulse assessment of all apheresis donors, we fulfil our medicolegal duty by not putting donors at avoidable risk. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=5469780 Fri, 02 Dec 2011 05:00:00 +0100 5469780 http://www.medworm.com/index.php?rid=5649235&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2012.01134.x Conclusion: We describe here an optimal method to obtain enough number of metaphases for karyotype analysis of in vitro expanded MSCs, what is essential for their clinical use in cell therapy programmes. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=5649235 Thu, 01 Dec 2011 05:00:00 +0100 5649235 http://www.medworm.com/index.php?rid=5639115&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2012.01132.x Conclusions: Arm skin disinfection with 10% povidone–iodine produced better antimicrobial activity. We must acknowledge that 10% povidone–iodine technique has the limitation of being a two‐stage method. However, prevention of adverse events due to bacterial contamination and transfusion reactions should be prioritised. Production of hypoallergenic and stronger antiseptics that allowed a safe one‐stage disinfection technique should be encouraged in health systems, not only in Brazil but also around the world. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=5639115 Thu, 01 Dec 2011 05:00:00 +0100 5639115 http://www.medworm.com/index.php?rid=5629853&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2012.01133.x (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=5629853 Thu, 01 Dec 2011 05:00:00 +0100 5629853 http://www.medworm.com/index.php?rid=5583360&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2011.01131.x Conclusion: Serum ferritin values >10 000 µg L−1 are considered pathognomic for conditions characterised by abnormal macrophage activation. In our case, serum ferritin levels correlate well with the disease activity and clinical response. This further supports our previous proposal that the activated macrophages play an important role in HHTR. Serum ferritin is a nonspecific marker of inflammation. A rapid specific bio‐marker to measure the activity of macrophages in SCD in HHTR is desirable, and this area warrants further investigation. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=5583360 Thu, 01 Dec 2011 05:00:00 +0100 5583360 http://www.medworm.com/index.php?rid=5553045&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2011.01130.x Conclusion: High percentage of patients had adherence to iron chelation, which is in contrast to previous studies. This may be attributed to the vigorous efforts of governmental and non‐governmental organisations in educating patients and provision of free drug and equipment in the past few years. The results were satisfying but still more is to be done to increase drug adherence and to minimise reasons causing poor compliance. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=5553045 Thu, 01 Dec 2011 05:00:00 +0100 5553045 http://www.medworm.com/index.php?rid=5538718&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2011.01126.x This article re‐appraises critically, but with due consideration to the limited technology of the times, the first remarkable in vivo demonstration of the effects of platelets demonstrated by the serial ‘Bleeding Times' reported by William Duke in 1910, when fresh blood was transfused to two thrombocytopenic people. It also speculates on the possible causes of the thrombocytopenia with which Duke's main patient presented. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=5538718 Thu, 01 Dec 2011 05:00:00 +0100 5538718 http://www.medworm.com/index.php?rid=5526237&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2011.01127.x Conclusion: There is a significant quantity of PFHb in IRRAD28 RBC units, and potentially in washed allogeneic RBC units. Clinical correlation is required to determine if this quantity of PFHb and the transfusion of potentially fragile RBCs causes adverse events. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=5526237 Thu, 01 Dec 2011 05:00:00 +0100 5526237 http://www.medworm.com/index.php?rid=5506087&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2011.01125.x Conclusions: Limited data support the use of rFVIIa as a reversal agent for serious bleeding in patients who are anticoagulated with PSAs. The optimal dose, role for concomitant use of platelets or antifibrinolytic agents and exact indications for reversal remain to be determined. Such investigations are urgently needed as use of PSAs increases. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=5506087 Thu, 01 Dec 2011 05:00:00 +0100 5506087 http://www.medworm.com/index.php?rid=5495477&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2011.01122.x Conclusions: There is an association between ovarian cancer recurrence and allogeneic perioperative blood transfusion in patients with advanced ovarian cancer undergoing cytoreductive surgery. These findings may have important implications in the perioperative management of those patients. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=5495477 Thu, 01 Dec 2011 05:00:00 +0100 5495477 http://www.medworm.com/index.php?rid=5477389&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2011.01118.x Conclusions: Additional training in TM would be beneficial to and welcomed by physicians in all training levels in all specialties. Innovative specialty‐specific educational programmes need to be developed and tested to ensure efficacy and durability. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=5477389 Thu, 01 Dec 2011 05:00:00 +0100 5477389 http://www.medworm.com/index.php?rid=5469779&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2011.01120.x Conclusions: Phylogenetic analysis of HIV‐1 DNA sequences has been a decisive tool in verifying suspected transmission of the virus from blood donor to recipient in Brazil. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=5469779 Thu, 01 Dec 2011 05:00:00 +0100 5469779 http://www.medworm.com/index.php?rid=5442122&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2011.01116.x (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=5442122 Fri, 25 Nov 2011 10:26:11 +0100 5442122 http://www.medworm.com/index.php?rid=5442123&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2011.01112.x (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=5442123 Fri, 25 Nov 2011 05:00:00 +0100 5442123 http://www.medworm.com/index.php?rid=5409594&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01117.x (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=5409594 Thu, 17 Nov 2011 01:26:59 +0100 5409594 http://www.medworm.com/index.php?rid=5409593&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2011.01115.x (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=5409593 Thu, 17 Nov 2011 01:26:45 +0100 5409593 http://www.medworm.com/index.php?rid=5409592&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2011.01114.x (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=5409592 Thu, 17 Nov 2011 01:26:44 +0100 5409592 http://www.medworm.com/index.php?rid=5409591&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2011.01113.x (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=5409591 Thu, 17 Nov 2011 01:26:42 +0100 5409591 http://www.medworm.com/index.php?rid=5362626&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2011.01103.x Conclusion: Overall, our data suggest that the automated washing procedure is safe and suitable for processing of thawed HPC‐A products and can be daily used in clinical routine. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=5362626 Thu, 27 Oct 2011 04:00:00 +0100 5362626 http://www.medworm.com/index.php?rid=5362625&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2011.01110.x Conclusion: A high deferral of blood donors due to anaemia, mostly associated with poverty was observed and deserves attention from the public health perspective. Blood centres should consider the profile of donors and their geographic location when planning mobile blood collection or regional campaigns. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=5362625 Sat, 01 Oct 2011 04:00:00 +0100 5362625 http://www.medworm.com/index.php?rid=5316319&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2011.01111.x Conclusion: A novel FUT1 allele 235C was identified, which greatly diminished the activity of α‐(1,2)‐fucosyltransferase. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=5316319 Sat, 01 Oct 2011 04:00:00 +0100 5316319 http://www.medworm.com/index.php?rid=5274788&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2011.01093.x Conclusions: The new collection procedure significantly reduced bacterial contamination of RBC concentrates. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=5274788 Sat, 01 Oct 2011 04:00:00 +0100 5274788 http://www.medworm.com/index.php?rid=5251504&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2011.01108.x (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=5251504 Sun, 25 Sep 2011 22:21:28 +0100 5251504 http://www.medworm.com/index.php?rid=5251503&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2011.01107.x (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=5251503 Sun, 25 Sep 2011 22:21:26 +0100 5251503 http://www.medworm.com/index.php?rid=5251502&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2011.01109.x (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=5251502 Sun, 25 Sep 2011 22:21:25 +0100 5251502 http://www.medworm.com/index.php?rid=5210093&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2011.01106.x Conclusion: Our data show that neither the two dose nor the one dose regime appear to provide adequate cover at delivery for a large percentage of pregnant women. This appears to be associated with the duration of the pregnancy past the 28 week dose but not associated with the RhD status of the foetus. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=5210093 Tue, 13 Sep 2011 00:02:16 +0100 5210093 http://www.medworm.com/index.php?rid=5197017&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2011.01101.x (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=5197017 Wed, 07 Sep 2011 07:50:43 +0100 5197017 http://www.medworm.com/index.php?rid=5197016&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2011.01100.x (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=5197016 Wed, 07 Sep 2011 07:50:42 +0100 5197016 http://www.medworm.com/index.php?rid=5197015&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2011.01099.x (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=5197015 Wed, 07 Sep 2011 07:50:41 +0100 5197015 http://www.medworm.com/index.php?rid=5197013&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2011.01105.x Conclusion: The BacT/ALERT method is more sensitive and should continue to be the gold standard for identifying bacterial contaminations in blood samples. The real‐time PCR approach can be used for the screening of PCs for microbial detection before they are released from blood centres or shortly before they are used in blood transfusion, and thus allow an extended shelf life of the platelets. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=5197013 Wed, 07 Sep 2011 07:50:18 +0100 5197013 http://www.medworm.com/index.php?rid=5197014&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2011.01102.x Discussion: Use of fresh blood produced significantly higher pre‐transfusion Hb, giving credence to UK consensus. Lesser volumes of fresh blood appeared to achieve the target pre‐transfusion Hb, which may translate to reduced iron overload and chelation costs. Whether the assumption that the use of blood less than 7 days old in these patients would result in greater benefit requires further study. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=5197014 Sun, 04 Sep 2011 23:00:00 +0100 5197014 http://www.medworm.com/index.php?rid=5144898&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2011.01098.x Conclusions: In our hospital, where transfusion guidelines are overseen by transfusion medicine specialists and technologists, and policies for rapid blood component and laboratory turnaround times exist, it is possible to achieve high rates of appropriateness for cryoprecipitate transfusion in trauma. The current recommended dose causes a modest increase in fibrinogen levels (0·55 g L−1). (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=5144898 Wed, 17 Aug 2011 23:00:00 +0100 5144898 http://www.medworm.com/index.php?rid=5132963&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2011.01094.x Discussion: The systematic use of blood count reference intervals and pre‐donation multiparameter blood counts allowed prompt identification of WBC, PLT and MCV alterations, readmittance within 15 days of 12·70% of initially excluded donors and contributed to prompt management of supplement deficiency. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=5132963 Mon, 15 Aug 2011 23:00:00 +0100 5132963 http://www.medworm.com/index.php?rid=5184904&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2011.01097.x Conclusions: HLA or ABO antibodies did not appear to be stimulated by the 2009 influenza vaccine. Female blood donors with putatively unrecognised pregnancies may have higher risk for HLA sensitisation than previously thought. Further study using different vaccine formulations may lead to better understanding of the risks of bystander antibodies in the blood donor population. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=5184904 Sun, 31 Jul 2011 23:00:00 +0100 5184904 http://www.medworm.com/index.php?rid=5144897&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2011.01095.x (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=5144897 Sun, 31 Jul 2011 23:00:00 +0100 5144897 http://www.medworm.com/index.php?rid=5132962&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2011.01096.x (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=5132962 Sun, 31 Jul 2011 23:00:00 +0100 5132962 http://www.medworm.com/index.php?rid=5040818&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2011.01092.x (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=5040818 Wed, 20 Jul 2011 18:32:49 +0100 5040818 http://www.medworm.com/index.php?rid=5040819&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2011.01079.x Conclusion: This study confirms that interventions to improve the blood supply must take into account local attitudes and conditions. In Bamenda, a variety of pragmatic approaches are required including education around specific biological misperceptions identified in the study and the retention of replacement donors as repeat donors. Issues around compensation for blood donation require further work. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=5040819 Sun, 17 Jul 2011 23:00:00 +0100 5040819 http://www.medworm.com/index.php?rid=5010565&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2011.01091.x Introduction. Following on from 2009's successful meeting ‘Transfusion Today’, the Royal College of Pathologists presented another fascinating 2‐day symposium ‘Transfusion Tomorrow’ to consider the future impact of recent advances in transfusion medicine. Topics ranged from blood safety issues and regulation, through clinical and laboratory practice, to molecular advances in transfusion science. The meeting focussed on the evidence base for developments in clinical practice and drew in a wide cross‐section of scientific, clinical and technical staff. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=5010565 Sat, 09 Jul 2011 20:53:16 +0100 5010565 http://www.medworm.com/index.php?rid=5010564&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2011.01090.x (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=5010564 Sat, 09 Jul 2011 20:53:15 +0100 5010564 http://www.medworm.com/index.php?rid=5010563&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2011.01087.x (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=5010563 Sat, 09 Jul 2011 20:53:14 +0100 5010563 http://www.medworm.com/index.php?rid=5010562&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2011.01088.x (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=5010562 Sat, 09 Jul 2011 20:53:13 +0100 5010562 http://www.medworm.com/index.php?rid=4971163&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2011.01083.x Conclusion: These results suggest that exposure to 10 °C for 12 h or for 5 and 12 h did not adversely affect in vitro red cell quality for the remainder of the components shelf life. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=4971163 Sat, 25 Jun 2011 23:00:00 +0100 4971163 http://www.medworm.com/index.php?rid=4971162&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2011.01084.x Conclusion: For blood transfusion safety, it is important to establish an effective screening algorithm to identify rare phenotypes, such as the K0 phenotype, and to establish a database of rare blood groups. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=4971162 Sat, 25 Jun 2011 23:00:00 +0100 4971162 http://www.medworm.com/index.php?rid=4923892&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2011.01081.x Conclusions: There was a high degree of polymorphism of the membrane glycoprotein genes related to human platelet alloantigen‐1 to ‐17w systems in the Chinese Han population. These data could have some impact on the diagnosis, prevention and treatment of alloimmune thrombocytopenia. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=4923892 Wed, 08 Jun 2011 23:00:00 +0100 4923892 http://www.medworm.com/index.php?rid=4923891&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2011.01082.x Conclusion: The prevalence of IgA deficiency in Chinese is low. However, potential risks exist in performing blood transfusion to IgA‐deficient persons, and measures should be taken to reduce IgA anaphylaxis. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=4923891 Wed, 08 Jun 2011 23:00:00 +0100 4923891 http://www.medworm.com/index.php?rid=5000041&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2011.01089.x (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=5000041 Tue, 31 May 2011 23:00:00 +0100 5000041 http://www.medworm.com/index.php?rid=4971161&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2011.01086.x (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=4971161 Tue, 31 May 2011 23:00:00 +0100 4971161 http://www.medworm.com/index.php?rid=4962057&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2011.01080.x Conclusion: Altruism and being encouraged by others had the leading roles in peoples' positive attitude towards blood donation; whereas hard access to blood donation centres seemed to be the main inhibitory factor. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=4962057 Tue, 31 May 2011 23:00:00 +0100 4962057 http://www.medworm.com/index.php?rid=4938772&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2011.01077.x Conclusion: This study showed that internal motives are the main reason for blood donation in Iranian donors, especially in female, regular and high‐educated donors. Thus, altruistic and religious messages can be emphasized in recruiting and retaining donors, particularly in this group. Nearly half of the donors were motivated by external factors – mainly to improve their own health status, especially in older donors. This may be due to a psychological impact in which they feel improvement in their general health. As voluntary non‐remunerated blood donation is defined without considering the motivational factor, one might consider a new term such as ‘internal motivated voluntary blood donors' in accordance with their motivation and efforts could be centered about recruiting these s... Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=4938772 Tue, 31 May 2011 23:00:00 +0100 4938772 http://www.medworm.com/index.php?rid=4923890&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2011.01085.x This article describes the key characteristics, methodologies and methods of qualitative research and draws on examples to show how qualitative research approaches have been applied in the field of transfusion medicine. It is hoped that this overview will inform and encourage the application of qualitative research in the field of transfusion medicine. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=4923890 Tue, 31 May 2011 23:00:00 +0100 4923890 http://www.medworm.com/index.php?rid=4886288&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2011.01076.x Conclusions: Our findings provide a fast and efficient method for mesenchymal cell isolation from Wharton's jelly using the total length of the UC. This method resulted in a large number of cells while the cells retained their mesenchymal character after thawing. This method can be easily applied, along with UC blood, for UC banking. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=4886288 Tue, 31 May 2011 23:00:00 +0100 4886288 http://www.medworm.com/index.php?rid=4854974&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2011.01078.x Conclusion: These cases illustrate the potential severity of haemolysis after IVIG because of passively transferred antibodies to blood group antigens. Lack of recognition of IVIG as a cause for haemolysis by clinicians may be further confounded if routine testing fails to detect the passively transferred ABO blood group antibodies. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=4854974 Tue, 24 May 2011 17:36:29 +0100 4854974 http://www.medworm.com/index.php?rid=4749304&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2011.01075.x Conclusions: When tested at 24 h after surgery, cytokine GE in peripheral blood leucocytes showed no significant differences between those transfused and those not transfused. Some alterations were seen in those developing MOF compared to those who did not, but the findings offer no role of leukocyte depleted (LD) RBC transfusion in the development of MOF. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=4749304 Tue, 26 Apr 2011 15:06:29 +0100 4749304 http://www.medworm.com/index.php?rid=4659705&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2011.01074.x (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=4659705 Thu, 31 Mar 2011 17:10:20 +0100 4659705 http://www.medworm.com/index.php?rid=4545950&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2011.01072.x Conclusion: Efforts should be made to propagate a similar protocol for the production of ASEs in blood centres capable of collecting and processing blood products, making this service affordable and uniformly accessible to patients. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=4545950 Thu, 03 Mar 2011 00:00:00 +0100 4545950 http://www.medworm.com/index.php?rid=4545949&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2011.01073.x Conclusions: This study revealed a maternal RBC alloimmunisation rate of 2·2% which was comparable with findings from a Zimbabwean study where the prevalence was 1·7%. Given the 6·0% prevalence of anti‐D among RhD‐negative women in our study and the high immunogenicity of the D antigen, programmes for preventing anti‐D alloimmunisation and HDFN in Uganda should be considered seriously. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=4545949 Thu, 03 Mar 2011 00:00:00 +0100 4545949 http://www.medworm.com/index.php?rid=4407372&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2011.01069.x Conclusion: Information leaflets could increase the information available to patients, with minimal impact on health care professionals' time. Leaflets are available, free of charge, from the National Health Service Blood and Transplant website. These have been introduced at each bedside, in pre‐op packs and in outpatient clinics, with re‐assessment planned in 6 months. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=4407372 Thu, 27 Jan 2011 00:00:00 +0100 4407372 http://www.medworm.com/index.php?rid=4407371&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2011.01070.x Conclusions: Our study demonstrates that routine bacterial testing of PCs was successfully implemented and the established algorithm proved efficient. The BactiFlow flow cytometric assay is the first rapid screening method which is suitable for a routine application combined with a high sensitivity. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=4407371 Thu, 27 Jan 2011 00:00:00 +0100 4407371 http://www.medworm.com/index.php?rid=4401456&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01068.x Conclusions: Pre‐test clinical scoring correlates well with the development of H‐PF4 antibodies which are incriminated in the causation of thrombotic complications in patients with HIT. We also propose a protocol for diagnosing patients with clinical suspicion of HIT using pre‐test clinical scoring and immunoassay. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=4401456 Thu, 27 Jan 2011 00:00:00 +0100 4401456 http://www.medworm.com/index.php?rid=4401455&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2011.01071.x (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=4401455 Thu, 27 Jan 2011 00:00:00 +0100 4401455 http://www.medworm.com/index.php?rid=4363927&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01066.x (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=4363927 Mon, 17 Jan 2011 00:00:00 +0100 4363927 http://www.medworm.com/index.php?rid=4332828&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01067.x (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=4332828 Tue, 11 Jan 2011 00:00:00 +0100 4332828 http://www.medworm.com/index.php?rid=4315117&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01064.x Conclusion: Of the 12 sera containing HPA‐1a (n = 2), HPA‐3a (n = 6), HPA‐6b (n = 3) or HPA‐7 variant (n = 1) antibodies, all antibodies were detected and determined by our new method, except for two HPA‐3a antibodies. One of the two antibodies was also negative for conventional platelet MAIPA, suggesting that the cell line panel might be used as an alternative source of platelet antigens in the MAIPA assay. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=4315117 Thu, 06 Jan 2011 00:00:00 +0100 4315117 http://www.medworm.com/index.php?rid=4315116&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01065.x Conclusions: These results suggest that preservation of mitochondrial function is fundamental, but not fully sufficient, for the maintenance of platelet in vitro quality during storage. Further research is necessary to develop methods for preserving both mitochondrial and platelet functions in in vitro stored PCs. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=4315116 Thu, 06 Jan 2011 00:00:00 +0100 4315116 http://www.medworm.com/index.php?rid=4315115&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01062.x Conclusion: Interpretation of the results by the automated analyser Techno TwinStation may be disturbed in some difficult samples, but in most of these cases the analyser reports not a false, but a doubtful result, thus triggering visual reading by the operator. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=4315115 Thu, 06 Jan 2011 00:00:00 +0100 4315115 http://www.medworm.com/index.php?rid=4296772&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01063.x Conclusions: PCA and PS exposure of stored RBCs increased during storage and showed significant positive correlation. PCA of long‐term stored RBCs may not be reversed by transfusion. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=4296772 Wed, 29 Dec 2010 00:00:00 +0100 4296772 http://www.medworm.com/index.php?rid=4296773&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01060.x Conclusion: At least 25% of RhD+ Indians are heterozygous at the RHD gene. Both the genotyping techniques were equally robust and their complete concordance indicates RHD deletion as the main mechanism underlying RhD negativity in Indians. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=4296773 Tue, 28 Dec 2010 00:00:00 +0100 4296773 http://www.medworm.com/index.php?rid=4282655&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01061.x Conclusion: We describe a patient who appeared to have haemolytic anaemia and renal failure associated with antibodies to both TMP and SMX. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=4282655 Wed, 22 Dec 2010 00:00:00 +0100 4282655 http://www.medworm.com/index.php?rid=4254646&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01059.x Conclusions: We recommend the use of weight or volume of the RCCs as the basis of estimating haemoglobin in the RCC and postulate that this can be used in future studies to explore the effects of a haemoglobin dose‐based transfusion system. As the weight – and sometimes the volume – of the blood bag is easily accessible, in contrast to direct haemoglobin measurements from each individual unit, this method is feasible and simple. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=4254646 Sun, 12 Dec 2010 00:00:00 +0100 4254646 http://www.medworm.com/index.php?rid=4246775&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01056.x This article reports on the toxicology of DEHP and considers concerns regarding its use in the context of transfusion medicine. The benefits of using DEHP are evaluated and the use of alternative plasticisers to DEHP is explored. The article reports on international and European regulatory recommendations for DEHP use in transfusion medicine and examines the impact of legislation on the medical devices and blood industries. The article also reviews labelling considerations for blood components and offers some guidance for blood establishments in respect of DEHP use. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=4246775 Wed, 08 Dec 2010 00:00:00 +0100 4246775 http://www.medworm.com/index.php?rid=4215713&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01053.x (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=4215713 Tue, 30 Nov 2010 00:00:00 +0100 4215713 http://www.medworm.com/index.php?rid=4215712&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01057.x Conclusion: On the basis of the look‐back study among the repeat donors in Hyogo‐Prefecture, Japan, donations with HBV‐infected blood negative for MP‐NAT occurred with a frequency of 13 in 685 844 donations (∼1/53 000 donations). However, more than half of the recipients transfused with HBV‐infected blood negative for MP‐NAT could not be followed up. It is necessary to establish a more cautious follow‐up system. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=4215712 Tue, 30 Nov 2010 00:00:00 +0100 4215712 http://www.medworm.com/index.php?rid=4215710&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01054.x Conclusion: The Grifols DG Gel® 8‐column system is reliable and safe for routine tests performed in the immunohaematology laboratory. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=4215710 Tue, 30 Nov 2010 00:00:00 +0100 4215710 http://www.medworm.com/index.php?rid=4215709&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01058.x Conclusion: In this setting the CS yields greater value for money than the HC method for screening blood donors. The relative cost and effectiveness of CS and HC may be different in places with higher staff turnover, lower test accuracy, higher anaemia prevalence or lower workload than in Vietnam. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=4215709 Tue, 30 Nov 2010 00:00:00 +0100 4215709 http://www.medworm.com/index.php?rid=4192743&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01055.x Conclusion: The first case of p phenotype in Taiwan was caused by a non‐functional allele resulting from a homozygous complex mutation of A4GALT gene. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=4192743 Wed, 24 Nov 2010 05:12:41 +0100 4192743 http://www.medworm.com/index.php?rid=4192744&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01051.x Conclusions: These results may lead to a discussion around the most suitable preanalytical conditions in blood donation environments. Contrary to the current PEI guidelines that allow storage of whole blood specimens up to 18 h at 21 °C, these results suggest that immediate storage in a 5 °C container after blood donation is more suitable and would permit storage of whole blood up to 24 h prior to the separation of plasma from cells. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=4192744 Tue, 23 Nov 2010 00:00:00 +0100 4192744 http://www.medworm.com/index.php?rid=4180307&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01052.x (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=4180307 Fri, 19 Nov 2010 06:01:30 +0100 4180307 http://www.medworm.com/index.php?rid=4165187&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01050.x Conclusion: This study suggests that a fixed dose of 1040 IU of F IX may be an effective way to rapidly counteract VKA therapy in our patient population and provides a basis for future research. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=4165187 Mon, 15 Nov 2010 09:12:25 +0100 4165187 http://www.medworm.com/index.php?rid=4160559&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01047.x Variant Creutzfeldt–Jakob disease (vCJD) can be transmitted by transfusion. The risk depends on the number of infected donors in the community. An estimate of these numbers in a less genetically susceptible population, based on the epidemic seen so far, suggests a maximum of 300 more cases. From this, it is possible to predict a maximum of one transfusion acquired case in 3 years from plasma transfusion. Importation of plasma from outside the UK has been advocated to prevent these cases and would cost around £30 million per year. An alternative measure is to use the observed susceptibility and exposure to dietary vCJD by age, and to target low risk donors for the production of components such as fresh frozen plasma (FFP) and platelets. This will reduce the possible cases of plasma trans... Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=4160559 Sat, 13 Nov 2010 05:02:45 +0100 4160559 http://www.medworm.com/index.php?rid=4153039&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01045.x (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=4153039 Thu, 11 Nov 2010 04:30:50 +0100 4153039 http://www.medworm.com/index.php?rid=4153041&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01048.x Conclusions: In this small registry of patients with SAH, the age of transfused PRBCs was not associated with adverse events or outcomes. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=4153041 Wed, 10 Nov 2010 00:00:00 +0100 4153041 http://www.medworm.com/index.php?rid=4153040&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01049.x Conclusion: Our survey demonstrated a wide range of responses consistent with important variations in clinical practice and substantial clinical uncertainty in relation to FFP treatment for non‐bleeding ICU patients. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=4153040 Wed, 10 Nov 2010 00:00:00 +0100 4153040 http://www.medworm.com/index.php?rid=4078923&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01044.x (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=4078923 Tue, 19 Oct 2010 13:35:31 +0100 4078923 http://www.medworm.com/index.php?rid=4078922&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01040.x (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=4078922 Tue, 19 Oct 2010 13:35:31 +0100 4078922 http://www.medworm.com/index.php?rid=4062609&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01046.x (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=4062609 Thu, 30 Sep 2010 23:00:00 +0100 4062609 http://www.medworm.com/index.php?rid=4057300&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01041.x Background: (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=4057300 Thu, 30 Sep 2010 23:00:00 +0100 4057300 http://www.medworm.com/index.php?rid=4033164&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01042.x Background: (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=4033164 Thu, 30 Sep 2010 23:00:00 +0100 4033164 http://www.medworm.com/index.php?rid=4033163&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01043.x (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=4033163 Thu, 30 Sep 2010 23:00:00 +0100 4033163 http://www.medworm.com/index.php?rid=4014962&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01039.x Objectives: (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=4014962 Thu, 30 Sep 2010 14:55:11 +0100 4014962 http://www.medworm.com/index.php?rid=3989733&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01037.x Background and Objective: (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=3989733 Thu, 23 Sep 2010 06:49:23 +0100 3989733 http://www.medworm.com/index.php?rid=3944329&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01038.x (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=3944329 Thu, 09 Sep 2010 06:12:29 +0100 3944329 http://www.medworm.com/index.php?rid=3818679&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01033.x Conclusion: The SBOE is a more accurate and cost-saving tool in predicting blood use. It should replace the current unaided method of ordering for perioperative blood in femoral fracture surgery at Mulago Hospital. However, its introduction to other hospitals should be preceded by more rigorous research to strengthen its external validity. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=3818679 Tue, 03 Aug 2010 23:00:00 +0100 3818679 http://www.medworm.com/index.php?rid=3818680&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01031.x (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=3818680 Mon, 02 Aug 2010 23:00:00 +0100 3818680 http://www.medworm.com/index.php?rid=3900967&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01034.x (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=3900967 Sat, 31 Jul 2010 23:00:00 +0100 3900967 http://www.medworm.com/index.php?rid=3893306&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01035.x (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=3893306 Sat, 31 Jul 2010 23:00:00 +0100 3893306 http://www.medworm.com/index.php?rid=3883086&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01031.x (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=3883086 Sat, 31 Jul 2010 23:00:00 +0100 3883086 http://www.medworm.com/index.php?rid=3878526&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01036.x (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=3878526 Sat, 31 Jul 2010 23:00:00 +0100 3878526 http://www.medworm.com/index.php?rid=3874167&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01032.x (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=3874167 Sat, 31 Jul 2010 23:00:00 +0100 3874167 http://www.medworm.com/index.php?rid=3836633&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.00993.x (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=3836633 Sat, 31 Jul 2010 23:00:00 +0100 3836633 http://www.medworm.com/index.php?rid=3836632&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.00991.x (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=3836632 Sat, 31 Jul 2010 23:00:00 +0100 3836632 http://www.medworm.com/index.php?rid=3836631&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.00997.x (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=3836631 Sat, 31 Jul 2010 23:00:00 +0100 3836631 http://www.medworm.com/index.php?rid=3836630&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01014.x (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=3836630 Sat, 31 Jul 2010 23:00:00 +0100 3836630 http://www.medworm.com/index.php?rid=3836629&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01009.x Confusion still exists in the diagnosis of drug‐induced immune haemolysis (DIH). The aim of this study was to demonstrate antibodies specific to 5‐fluorouracil (5‐FU) in a patient with fatal immune haemolysis (IH). The case of a patient who died due to protracted IH is described. A 57‐year‐old female underwent treatment with oxaliplatin, 5‐FU and folinic acid due to cholangiocarcinoma. Following drug administration, she was transfused because of a mild non‐haemolytic anaemia and died following haemolysis. Serological testing including antibody screening, direct antiglobulin test and detection of drug‐dependent antibodies was performed using standard techniques. The patient's serum was observed to be red in colour due to the presence of free haemoglobin prior to and followin... Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=3836629 Sat, 31 Jul 2010 23:00:00 +0100 3836629 http://www.medworm.com/index.php?rid=3836628&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01006.x Thrombotic thrombocytopenic purpura (TTP) has been associated with human immunodeficiency virus (HIV) infection. With the high prevalence of HIV in sub‐Saharan Africa, HIV‐associated TTP is the most common form of this disease seen in the South African population. Several case reports describe myocardial infarction in HIV‐negative TTP patients. The case of the first HIV‐positive patient who presented with clinical signs and symptoms of TTP and myocardial injury is reported in this study. A patient with fragmentation haemolysis and thrombocytopenia presented with angina. Risk factors for ischaemic heart disease were absent. An electrocardiogram (EKG) revealed ST‐segment elevation and a significantly raised Troponin T level. The patient's HIV test was positive and a diagnosis of my... Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=3836628 Sat, 31 Jul 2010 23:00:00 +0100 3836628 http://www.medworm.com/index.php?rid=3836627&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.00999.x The aim of the study was to document the incidence of adverse reactions (ADRs) in subjects undergoing therapeutic plasma exchange with human albumin 4·5% solution (Zenalb® (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=3836627 Sat, 31 Jul 2010 23:00:00 +0100 3836627 http://www.medworm.com/index.php?rid=3836626&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.00998.x This study has pinpointed nine main barriers to blood donation among the French population, the most significant being medical reasons (for both lapsed and non‐donors), lack of time, cited more frequently by lapsed donors, and fear of donating blood, most often cited by non‐donors. Future studies are needed to gain greater insight into what these barriers represent for individuals to improve awareness and for recruitment of French blood donors. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=3836626 Sat, 31 Jul 2010 23:00:00 +0100 3836626 http://www.medworm.com/index.php?rid=3836625&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01000.x The aim of the study is to evaluate the effects of red blood cell (RBC) transfusions on pulmonary parameters in critically ill, non‐bleeding patients. Retrospective chart analysis was performed on critically ill patients without overt bleeding in the intensive care unit (ICU) of a university hospital. In 83 patients in a 5‐month period, who had received at least 1 RBC unit and stayed at least 24 h in the ICU, 199 transfusions of median 2 RBCs per transfusion (n (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=3836625 Sat, 31 Jul 2010 23:00:00 +0100 3836625 http://www.medworm.com/index.php?rid=3806849&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01024.x Conclusions: RCC produced following the remanufacture of RCC in plasma or the delayed manufacture of whole blood are of acceptable in vitro quality and should be assigned the same shelf life as standard RCC in SAG-M. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=3806849 Sat, 31 Jul 2010 23:00:00 +0100 3806849 http://www.medworm.com/index.php?rid=3796531&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01025.x Blood services routinely separate whole blood into components that are then stored under different conditions. The storage conditions used for whole blood prior to separation must therefore be a compromise between the needs of the red cells (which benefit from refrigeration) and plasma and platelets (which are better preserved at ambient temperature). For many years, the approach has been to manufacture plasma and platelet components on the day of blood collection, and to refrigerate any unprocessed blood for manufacture into red cell components on the following day. However, this can make it challenging to maintain adequate stocks of all components. The European practice of 'ambient hold' of whole blood for up to 24 hours prior to processing allows greater flexibility in blood component m... Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=3796531 Wed, 28 Jul 2010 23:00:00 +0100 3796531 http://www.medworm.com/index.php?rid=3796533&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01023.x Conclusions: The CR1 gene in the Chinese people is more conservative than that in the Caucasian or African people. Different Chinese ethnic groups may have their own different CR1 gene characteristics. The existence of 4646G in the Uigur and Tu ethnic groups suggests that both may carry certain Caucasian characteristics in the CR1 gene. The frequency of 4870G in the Lisu and Dong ethnic groups implies possible incidence of evolutionary pressure similar to what the Africans had experienced. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=3796533 Tue, 27 Jul 2010 23:00:00 +0100 3796533 http://www.medworm.com/index.php?rid=3796532&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01020.x Conclusion: The HPA-3 and -15 appear to the highest priority and HPA-2, -6, -5 -1 and -4 to be the second priority in Chinese Cantonese when it comes to the diagnosis of neonatal alloimmune thrombocytopenia and to provide the HPA-matched platelet for patients with platelet transfusion refractoriness. The PCR-SSP method makes it possible to detect genotype of HPA-1 to -16 in less than 4 h and to establish a donor database for HPA genotype in a blood bank. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=3796532 Tue, 27 Jul 2010 23:00:00 +0100 3796532 http://www.medworm.com/index.php?rid=3774060&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01022.x Conclusions: IVIG is used relatively infrequently in the critical care setting. The most common indications were GBS, TEN and NF. Mortality was high. There was no difference between community and academic ICUs. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=3774060 Wed, 21 Jul 2010 23:00:00 +0100 3774060 http://www.medworm.com/index.php?rid=3751992&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01018.x (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=3751992 Wed, 14 Jul 2010 23:00:00 +0100 3751992 http://www.medworm.com/index.php?rid=3836620&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01018.x (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=3836620 Wed, 30 Jun 2010 23:00:00 +0100 3836620 http://www.medworm.com/index.php?rid=3836619&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01020.x (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=3836619 Wed, 30 Jun 2010 23:00:00 +0100 3836619 http://www.medworm.com/index.php?rid=3685121&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01021.x Conclusion: This study shows the insufficient effectiveness of HBsAg screening in protecting blood recipients from HBV infection. Inclusion of anti-HBc testing should be considered in the screening of blood donors. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=3685121 Tue, 22 Jun 2010 23:00:00 +0100 3685121 http://www.medworm.com/index.php?rid=3650140&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01019.x (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=3650140 Thu, 10 Jun 2010 23:00:00 +0100 3650140 http://www.medworm.com/index.php?rid=3646274&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01017.x Conclusion: The occurrence of HE in several members suggests familial aggregation. Indeed, in repeated measures, stability of the MFI values is suggesting an inherited condition. Factors outside the ABO locus might be responsible for the HE phenotype. Whether the real mechanism of inheritance is either of a polygenic or of a discrete Mendelian nature remains to be elucidated. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=3646274 Wed, 09 Jun 2010 23:00:00 +0100 3646274 http://www.medworm.com/index.php?rid=3646275&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01013.x There is potential for inappropriate use of transfusion administration sets when used in combination with modern infusion pumps with consequences for patient safety. The aims of our study were to (i) establish if the design and testing of transfusion sets specified in International Standard ISO 1135-4 are adequate for their current applications, (ii) identify if infusion pumps currently supplied in the UK for blood component administration are suitable for this purpose and (iii) determine the additional control measures needed to be applied by manufacturers and users to ensure patient safety. Keyword literature search was carried out to review and correlate important transfusion parameters with resultant adverse effects. Units for occlusion pressure, flow rate and haemolysis were standardi... Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=3646275 Tue, 08 Jun 2010 23:00:00 +0100 3646275 http://www.medworm.com/index.php?rid=3619357&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01014.x (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=3619357 Tue, 01 Jun 2010 23:00:00 +0100 3619357 http://www.medworm.com/index.php?rid=3619356&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01015.x Conclusion: A considerable amount of blood does not reach hospitals because of process delays between collection and ultimate dispatch. This is caused by a thin staff working with inadequate materials, out-of-date methods and in an overcrowded environment. Provision of adequate staff and improved financial allocations to the Uganda Blood Transfusion Services will mitigate this situation. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=3619356 Tue, 01 Jun 2010 23:00:00 +0100 3619356 http://www.medworm.com/index.php?rid=3836621&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01021.x (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=3836621 Mon, 31 May 2010 23:00:00 +0100 3836621 http://www.medworm.com/index.php?rid=3612878&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01016.x Conclusion: In spite of the biochemical, structural and functional changes associated with the storage of RBCs, their in vitro interactions with oxygen were largely preserved through 42 days of storage. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=3612878 Sun, 30 May 2010 23:00:00 +0100 3612878 http://www.medworm.com/index.php?rid=3547577&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01011.x We report cases of highly HLA-sensitized patients whose only satisfactory platelet transfusion responses were consistently associated with products compatible for both HLA- and ABO-matched (HLA-m/ABO-m) platelets, and in whom unsatisfactory increments occurred if either form of major incompatibility was permitted (HLA-u or ABO-u). Absolute platelet increments (APIs) were measured and classified as satisfactory if [ge]10 and unsatisfactory if (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=3547577 Sun, 09 May 2010 23:00:00 +0100 3547577 http://www.medworm.com/index.php?rid=3547576&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01012.x (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=3547576 Sun, 09 May 2010 23:00:00 +0100 3547576 http://www.medworm.com/index.php?rid=3539980&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01010.x (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=3539980 Thu, 06 May 2010 23:00:00 +0100 3539980 http://www.medworm.com/index.php?rid=3531789&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01009.x Confusion still exists in the diagnosis of drug-induced immune haemolysis (DIH). The aim of this study was to demonstrate antibodies specific to 5-fluorouracil (5-FU) in a patient with fatal immune haemolysis (IH). The case of a patient who died due to protracted IH is described. A 57-year-old female underwent treatment with oxaliplatin, 5-FU and folinic acid due to cholangiocarcinoma. Following drug administration, she was transfused because of a mild non-haemolytic anaemia and died following haemolysis. Serological testing including antibody screening, direct antiglobulin test and detection of drug-dependent antibodies was performed using standard techniques. The patient's serum was observed to be red in colour due to the presence of free haemoglobin prior to and following blood transfus... Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=3531789 Tue, 04 May 2010 23:00:00 +0100 3531789 http://www.medworm.com/index.php?rid=3836622&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01010.x (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=3836622 Fri, 30 Apr 2010 23:00:00 +0100 3836622 http://www.medworm.com/index.php?rid=3500230&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01008.x In this study, the Haemonetics Cymbal device was used to collect RCC using citrate, phosphate and dextrose (CPD-50) anticoagulant. A total of 10 procedures each yielded two leucodepleted RCC in saline, adenine, glucose and mannitol (SAGM) additive solution. One of each pair of RCC was kept warm in an insulated transport bag for 8 h and the other for 6 h. In vitro assessments of the quality of the RCC were made during subsequent 42-day storage of the RCC at 2[ndash]6 °C, and compared with reference data. All collected RCC were within UK and European limits for volume, haematocrit and haemoglobin content. Haemolysis was within specification at Day 42 and was no different in RCC held warm for 6 or 8 hours, but tended to be higher than reference data from whole blood derived RCC. ATP, 2,3 DPG... Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=3500230 Fri, 23 Apr 2010 23:00:00 +0100 3500230 http://www.medworm.com/index.php?rid=3469484&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01007.x Because of the high prevalence of Hepatitis B virus (HBV), HBsAg tests play an extremely significant role in donor screening in China. In our multicentre study, the HBsAg assays used in blood screening were evaluated for their analytical sensitivity and the ability to detect mutants. A panel of eight samples was sent to 85 blood banks. The panel included four HBsAg-positive serum samples at concentrations of 0·16, 0·46, 0·9 and 1·73 IU mL[minus]1; three recombinant HBsAg mutants (G145R, T131I and K141E) with defined concentrations and one negative sample. All laboratories were required to detect the samples with their routine procedures.All the 85 blood banks reported their results before the closing date, and 170 data sets were submitted. The wild-type samples at concentrations of 1·... Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=3469484 Wed, 14 Apr 2010 23:00:00 +0100 3469484 http://www.medworm.com/index.php?rid=3469485&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01006.x Thrombotic thrombocytopenic purpura (TTP) has been associated with human immunodeficiency virus (HIV) infection. With the high prevalence of HIV in sub-Saharan Africa, HIV-associated TTP is the most common form of this disease seen in the South African population. Several case reports describe myocardial infarction in HIV-negative TTP patients. The case of the first HIV-positive patient who presented with clinical signs and symptoms of TTP and myocardial injury is reported in this study. A patient with fragmentation haemolysis and thrombocytopenia presented with angina. Risk factors for ischaemic heart disease were absent. An electrocardiogram (EKG) revealed ST-segment elevation and a significantly raised Troponin T level. The patient's HIV test was positive and a diagnosis of myocardial i... Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=3469485 Tue, 13 Apr 2010 23:00:00 +0100 3469485 http://www.medworm.com/index.php?rid=3445690&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01003.x The objective of this study was to investigate the presence of this microorganism among blood donors. Blood samples were collected between November 2004 and March 2005 from 196 healthy blood donors. Ten millilitre of blood was collected in ethylenediaminetetraacetic (EDTA) tube. Reverse transcription of RNA was performed with Moloney murine leukaemia virus (MMLV) reverse transcriptase and random primers hexamer. Polymerase chain reaction products were evaluated by electrophoresis. Data were analysed using the [chi]2 test and t-test. Of the 196 healthy blood donors, 7·1% were C. pneumoniae DNA positive (CI 95 % = 3·51[ndash] 10·69), which is slightly higher in female (8·5%) than male (6·5%) donors; this difference was not found to be significant (P = 0·4). The average age of study gro... Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=3445690 Wed, 07 Apr 2010 23:00:00 +0100 3445690 http://www.medworm.com/index.php?rid=3445689&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01005.x Sometimes commercial RBC sets for the screening of irregular antibodies contain Wr(a+) cells. The aim of this study was to define the usefulness of employing RBC sets for the screening of irregular antibodies containing Wr(a+) cells in pre-transfusion tests. Anti-Wra is a relatively common naturally occurring antibody in candidates to blood transfusion, although the risk of receiving a non-compatible unit is low. We have studied both the incidence of Wra antibodies and the effects of having a Wr(a+) cell in the screening test on routine work in an unselected population of 787 patients requiring RBC transfusion and in 151 new blood donors. Irregular antibodies were found in 64 sera, 58 of which were specific for Wra, 46 (5·8%) and 12 (7·9%) in patients and donors, respectively. The positi... Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=3445689 Wed, 07 Apr 2010 23:00:00 +0100 3445689 http://www.medworm.com/index.php?rid=3836624&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01005.x (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=3836624 Wed, 31 Mar 2010 23:00:00 +0100 3836624 http://www.medworm.com/index.php?rid=3836623&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01008.x (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=3836623 Wed, 31 Mar 2010 23:00:00 +0100 3836623 http://www.medworm.com/index.php?rid=3400803&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01004.x There have been efforts to increase the quality of cord blood (CB) collections aimed at banking and transplantation. Yet, the effect of CB collection techniques on haemostatic activation is scarcely studied, despite the unique nature of the neonatal haemostatic system. The aim of this study was to explore coagulation system and platelet (PLT) activation during CB collection at a national CB bank. At three time points over a 9-year period (in 1998, 2000 and 2006), CB collections were assessed to evaluate the collection process during bank setup and changes in procedures. Thrombin generation and PLT activation were assessed with prothrombin activation fragment 1 + 2 (F1 + 2) and PLT factor 4 (PF4), respectively. The median F1 + 2 level was 2·8 nmol L[minus]1 in 1998 (n = 11), 0·7 nmol L[mi... Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=3400803 Thu, 25 Mar 2010 00:00:00 +0100 3400803 http://www.medworm.com/index.php?rid=3400804&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01001.x (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=3400804 Wed, 24 Mar 2010 00:00:00 +0100 3400804 http://www.medworm.com/index.php?rid=3351968&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.01000.x The aim of the study is to evaluate the effects of red blood cell (RBC) transfusions on pulmonary parameters in critically ill, non-bleeding patients. Retrospective chart analysis was performed on critically ill patients without overt bleeding in the intensive care unit (ICU) of a university hospital. In 83 patients in a 5-month period, who had received at least 1 RBC unit and stayed at least 24 h in the ICU, 199 transfusions of median 2 RBCs per transfusion (n = 504) were studied. Pulmonary parameters were retrieved during the period between 24 h before the start of transfusion and 24[ndash]48 h after transfusion. Outcome was assessed. The PaO2/FIO2 dose-dependently decreased from 250 ± 105 at baseline to 240 ± 102 mmHg at 24 h after RBC transfusion (P = 0·003), irrespective of acute l... Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=3351968 Thu, 11 Mar 2010 00:00:00 +0100 3351968 http://www.medworm.com/index.php?rid=3351967&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.00999.x The aim of the study was to document the incidence of adverse reactions (ADRs) in subjects undergoing therapeutic plasma exchange with human albumin 4·5% solution (Zenalb® 4·5) and to explore whether there were any differences in tolerability with a change from UK to US plasma and a subsequent manufacturing modification. Zenalb® 4·5 was initially manufactured from recovered plasma from UK blood donations and later from source plasma from US donors. The modification was a salt diafiltration step. A prospective survey was conducted at three UK aphaeresis units; data from 154 subjects undergoing 1195 plasma exchanges using Zenalb® 4·5 were collected. Adverse events with at least a possible relationship to treatment were recorded. There were 20 ADRs per 1195 exchanges (1·7%), experienc... Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=3351967 Thu, 11 Mar 2010 00:00:00 +0100 3351967 http://www.medworm.com/index.php?rid=3299796&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.00989.x This study demonstrates that clear and detailed transfusion guidelines based on simple bedside clinical features can be used in a very busy children's hospital in sub-Saharan Africa. With minimal additional equipment, volume and duration of transfusion can be well controlled. Furthermore, having a protocol in place results in a significant reduction of avoidable transfusions. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=3299796 Wed, 24 Feb 2010 00:00:00 +0100 3299796 http://www.medworm.com/index.php?rid=3296059&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.00998.x This study has pinpointed nine main barriers to blood donation among the French population, the most significant being medical reasons (for both lapsed and non-donors), lack of time, cited more frequently by lapsed donors, and fear of donating blood, most often cited by non-donors. Future studies are needed to gain greater insight into what these barriers represent for individuals to improve awareness and for recruitment of French blood donors. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=3296059 Tue, 23 Feb 2010 00:00:00 +0100 3296059 http://www.medworm.com/index.php?rid=3252253&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.00996.x (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=3252253 Tue, 09 Feb 2010 00:00:00 +0100 3252253 http://www.medworm.com/index.php?rid=3252252&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.00997.x (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=3252252 Tue, 09 Feb 2010 00:00:00 +0100 3252252 http://www.medworm.com/index.php?rid=3241355&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.00993.x (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=3241355 Fri, 05 Feb 2010 00:00:00 +0100 3241355 http://www.medworm.com/index.php?rid=3237447&cid=s_29469_19_f&fid=29469&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-3148.2010.00995.x In this study, we demonstrated that the establishment of an HLA- and HPA-typed platelet aphaeresis donor registry is useful to improve the treatment outcome of PTR patients and to maintain a long-term platelet transfusion strategy. (Source: Transfusion Medicine) Transfusion Medicine journals http://www.medworm.com/rss/comments.php?id=3237447 Thu, 04 Feb 2010 00:00:00 +0100 3237447