MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Transfusion and Apheresis Science' source. Sun, 29 Jan 2012 17:38:29 +0100 http://www.medworm.com/index.php?rid=5442183&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211001893%2Fabstract%3Frss%3Dyes (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5442183 Fri, 25 Nov 2011 10:35:04 +0100 5442183 http://www.medworm.com/index.php?rid=5442182&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211001765%2Fabstract%3Frss%3Dyes Abstract: Amongst the presentations featured at Scotblood 2011 were advances in diagnostic tests for antibodies to red blood cells, the establishment of an islet isolation laboratory, and the development of a clinical product for corneal stem cell transplantation. In addition, the conference comprised presentations on state-of-the-art in collection, storage, and clinical utility of haemopoietic progenitor cells. It also included a session on blood banking systems dedicated to an SNBTS colleague, the late Russell Graham. Finally, the keynote lecture was delivered by Prof. John Forsythe on behalf of the Safety of Blood, Tissues and Organs (SaBTO) members, while the Iain Cook Memorial Lecture was delivered by the recently retired SNBTS R&D director, Prof. Chris Prowse. (Source: Transfusion an... Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5442182 Fri, 25 Nov 2011 10:35:04 +0100 5442182 http://www.medworm.com/index.php?rid=5442181&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211001601%2Fabstract%3Frss%3Dyes To Editor, Thrombotic thrombocytopenic purpura (TTP) is a syndrome characterized by fever, microangiopathic hemolytic anemia, thrombocytopenia, renal disease and neurologic changes. TTP constitutes a poorly understood multisystemic disease of vascular origin that may involve any organ by thrombotic occlusions of the small vessels. It may be idiopathic or secondary. There is a range of clinical conditions that trigger the onset of acute TTP. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5442181 Fri, 25 Nov 2011 10:35:04 +0100 5442181 http://www.medworm.com/index.php?rid=5442180&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211001753%2Fabstract%3Frss%3Dyes Abstract: Hemostasis is of critical importance in achieving a positive outcome in any surgical intervention. Different hemostatic methods can be employed and topical hemostatic agents are used in a wide variety of surgical settings. Procoagulation agents have different hemostatic properties and the choice of a specific one is determined by the type of surgical procedure and bleeding. Hemostatic treatments include fibrin sealants, microfibrillar collagen, gelatin hemostatic agents, oxidized regenerated cellulose and cyanoacrylates adhesives. Surgeons should be familiar with topical hemostatics to ensure an appropriate use. Our purpose is to illustrate the currently available agents, their mechanism of action and their effective applications, in order to ensure an optimal use in operating ro... Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5442180 Fri, 25 Nov 2011 10:35:04 +0100 5442180 http://www.medworm.com/index.php?rid=5442179&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211001741%2Fabstract%3Frss%3Dyes Abstract: Transfusions in cardiac surgery are associated with an increased morbidity and mortality rate. However, no information is available with respect to the recovery process of transfused patients after discharge from the hospital. Two-hundred-seventeen patients who underwent cardiac surgery operations requiring packed red cells transfusions were studied during the rehabilitation stay. The exercise tolerance (6-min walk test) was not dependent on the number of packed red cells units transfused. Conversely, the length of stay in the rehabilitation hospital was independently associated (P=0.004) with the number of packed red cells transfused, with an increase of 0.6days per each unit transfused. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5442179 Fri, 25 Nov 2011 10:35:04 +0100 5442179 http://www.medworm.com/index.php?rid=5442178&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS147305021100173X%2Fabstract%3Frss%3Dyes Abstract: This paper reviews co-factors that impact on oxygen delivery and uptake, in the attempt to unravel the mechanisms underlying the correlation between the decrease in oxygen delivery and oxygen consumption. In sequence, the following factors are analyzed that, besides a decrease in haemoglobin concentration, impair tissue metabolism: (1) lung diffusion and perfusion limitation in oxygen transport, (2) decrease in cardiac output, (3) impairment of peripheral microvascular perfusion and (4) reduced ability of cells to extract oxygen. The contribution of the various factors is modeled aiming to present a decisional flow chart for the functional evaluation of the efficiency of the oxygen transport system. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5442178 Fri, 25 Nov 2011 10:35:04 +0100 5442178 http://www.medworm.com/index.php?rid=5442177&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211001728%2Fabstract%3Frss%3Dyes Abstract: Massive bleeding accounts for more than 50% of all trauma-related deaths within the first 48h following hospital admission and it can significantly raise the mortality rate of any kind of surgery. Despite this great clinical relevance, evidence on the management of massive bleeding is surprisingly scarce, and its treatment is often based on empirical grounds. Successful treatment of massive haemorrhage depends on better understanding of the associated physiological changes as well as on good team work among the different specialists involved in the management of such a complex condition. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5442177 Fri, 25 Nov 2011 10:35:04 +0100 5442177 http://www.medworm.com/index.php?rid=5442176&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211001716%2Fabstract%3Frss%3Dyes Abstract: Background: Large use of allogeneic red blood cell concentrates (RBCc), albeit necessary in major surgery, may influence patients’ outcome.Design and methods: We introduced an integrated strategy including patients’ evaluation and supplementation associated with autologous blood collection and saving to support major elective surgery at our hospital since 2008. After 2years of stabilization of this approach, we analyzed the results obtained in 2010 in terms of allogeneic blood usage and reduction of transfusion of stored RBCc.Results: Analyzing 2010 results we found that usage of total autologous RBCc units was increased by 2.2 folds, of “not stored” autologous RBCc units by 2.4 folds and of allogeneic RBCc unit transfusion reduced by 65%. The significant reduction in the... Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5442176 Fri, 25 Nov 2011 10:35:04 +0100 5442176 http://www.medworm.com/index.php?rid=5442175&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211001704%2Fabstract%3Frss%3Dyes Conclusion: Continued use of aspirin does not increase the risk of overall bleeding or moderate and severe haematuria after prostatic biopsy, and thus stopping aspirin before such biopsies is unnecessary. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5442175 Fri, 25 Nov 2011 10:35:04 +0100 5442175 http://www.medworm.com/index.php?rid=5442174&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211001686%2Fabstract%3Frss%3Dyes Abstract: Acute normovolemic hemodilution (AHN) is a well known but poorly used “blood saving” method. The authors, based on their own experience and on the “low hematocrit” physiology, present some concepts on AHN and a clinical experience to demonstrate the usefulness and affordability of this method. Consequently we offer several tools concerning both the realization of AHN and the safe use of such dilution, suggesting simple and exciting methods to determine if, when and how to apply this blood saving system. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5442174 Fri, 25 Nov 2011 10:35:04 +0100 5442174 http://www.medworm.com/index.php?rid=5442173&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211001674%2Fabstract%3Frss%3Dyes Abstract: An efficient Blood Conservation Program (BCP) should be considered in preparation of the surgical patient transfusion requirement. BCP should account for the association between bleeding reduction and anemia during or post surgery. In this paper, our aim was to develop a predictive model of bleeding that could help direct decision making about the strategy to reduce unnecessary transfusions. Such a strategy could guarantee an adequate peri-operative hemoglobin value, to reduce the patients’ risk and rehabilitation time.Moreover, an accurate prediction of bleeding and anemia helps to plan preventive autologous transfusion or erythropoietic stimulus, to enhance a conservative transfusion approach, reducing both costs and risks. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5442173 Fri, 25 Nov 2011 10:35:04 +0100 5442173 http://www.medworm.com/index.php?rid=5442172&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211001698%2Fabstract%3Frss%3Dyes (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5442172 Fri, 25 Nov 2011 10:35:04 +0100 5442172 http://www.medworm.com/index.php?rid=5442171&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211001662%2Fabstract%3Frss%3Dyes That is not the beginning of a joke, but the beginning of ANEMO. ANEMO is born from an idea of two physicians, a hematologist (GI) and an anesthetist (MP) who care for blood saving: they started to inform, sensitize and involve physicians and surgeons about these issues through meetings and publications. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5442171 Fri, 25 Nov 2011 10:35:04 +0100 5442171 http://www.medworm.com/index.php?rid=5442170&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211001820%2Fabstract%3Frss%3Dyes Abstract: Objective: We analyzed the efficacy of continuous renal replacement therapy (CRRT) combined with blood transfusion for patients with crush syndrome from an earthquake.Methods: Eight patients with crush syndrome were included. CRRT were performed in six of eight patients with crush syndrome, and transfusion was performed in all eight patients. Routine blood tests, urea nitrogen, creatinine, blood coagulation function, electrolyte levels, and serum myoglobin were determined and analyzed.Results: Two patients regained their health completely, four patients required amputation but recovered well, and two patients died. The total amount of red blood cells transfused in the eight cases was 521U (mean volume=68.25U). CRRT was performed 164 times in six patients (mean 27.33 times per per... Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5442170 Fri, 25 Nov 2011 10:35:04 +0100 5442170 http://www.medworm.com/index.php?rid=5442169&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211001650%2Fabstract%3Frss%3Dyes We describe our experience with plasma exchange (PE) and immunoadsorption in patients with myasthenia gravis. The group of 27 patients consists of 21 patients treated with PE and 6 patients who received immunoadsorption. PE therapy led to stabilization in 20 patients. In patients treated with immunoadsorption, therapy could be discontinued in 2 patients after 13months of therapy, and the other 4 patients were stabilized without myasthenic crises after 6–9years of therapy. Extracorporeal elimination therapy through PE or immunoadsorption is effective and sometimes life saving and is safe in the hands of an experienced team (6% complication rate). (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5442169 Fri, 25 Nov 2011 10:35:04 +0100 5442169 http://www.medworm.com/index.php?rid=5442168&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211001649%2Fabstract%3Frss%3Dyes Abstract: In between the dates of February 2008–March 2009, by applying to Istanbul University CTF Microbiology and Clinical Microbiology Basic Sciences Branch and Duzen laboratories, 123 cases, where HCV RNA and anti-HCV positivity are identified with molecular (real-time PCR) and serologic (ELISA) methods as a positive control group, and 48 cases where HCV RNA and anti-HCV negativity are identified as a negative control group are established. The values of sensitivity, specificity, positive and negative approximation of recently developed HCV Core Ag (Abbott Diagnostics, Germany) kit are determined successively as 94.3%, 97.9%, 99.1%, 87%, 95.3% and 88%. Although the new HCV Ag assay is clearly not sensitive enough to replace HCV NAT it may serve as a valuable tool in the HCV diagnosti... Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5442168 Fri, 25 Nov 2011 10:35:04 +0100 5442168 http://www.medworm.com/index.php?rid=5442167&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211001625%2Fabstract%3Frss%3Dyes Conclusion: Our results of TPE in neurological disorders and in atypical hemolytic uremic syndrome are encouraging and it is a cost effective alternative to IvIg in neurological disorders. Currently, there is a need for establishment of an Indian apheresis registry to understand the scenario of TA across the country and in the expansion of appropriate and applicable indications for TA in our setting. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5442167 Fri, 25 Nov 2011 10:35:04 +0100 5442167 http://www.medworm.com/index.php?rid=5442166&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211001637%2Fabstract%3Frss%3Dyes International Congress of Clinical Transfusiology, Polish National Transfusion Service September 24th 2010, Hotel Ossa, Ossa, Poland This symposium was a part of the International Congress of Clinical Transfusiology, which took place in September 2010 in Ossa, Poland. An overview of the Mirasol Pathogen Reduction Technology (PRT) and the results from its use in research and clinical settings were presented. Among presenters were research scientists and doctors who used PRT treated blood components in the research laboratories and routinely for the transfusion support of patients. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5442166 Fri, 25 Nov 2011 10:35:04 +0100 5442166 http://www.medworm.com/index.php?rid=5442165&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211001832%2Fabstract%3Frss%3Dyes Blood and blood components have never been as safe as they are now. The substantial progress in safety improvement has been achieved through: more restrictive donor selection, implementation of more sensitive serological and molecular biology tests, quarantine of plasma, preparation within a closed system and quality assurance (QA) establishment in blood transfusion service. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5442165 Fri, 25 Nov 2011 10:35:04 +0100 5442165 http://www.medworm.com/index.php?rid=5442164&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211001881%2Fabstract%3Frss%3Dyes We are delighted to have information from the Polish Blood Transfusion Service featured in the International Forum of this issue. Dr. Pogłód has written a very comprehensive overview of the evolution of activities in that country and the current emphasis on blood safety as represented by the use of various plasmas that have been either quarantined or subject to one of two forms of pathogen inactivation. This is followed by a summary article from Dr. Anna Ettinger from Caridian in which she reviewed the information presented at the symposium at the International Congress of Clinical Transfusiology; Polish National Transfusion Service, held in Ossa, Poland, September 24th 2010. It is indeed interesting to see the effective manner in which some countries, such as Poland, are moving forward ... Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5442164 Fri, 25 Nov 2011 10:35:04 +0100 5442164 http://www.medworm.com/index.php?rid=5442163&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211001935%2Fabstract%3Frss%3Dyes (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5442163 Fri, 25 Nov 2011 10:35:04 +0100 5442163 http://www.medworm.com/index.php?rid=5286704&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS147305021100139X%2Fabstract%3Frss%3Dyes (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5286704 Sat, 01 Oct 2011 04:00:00 +0100 5286704 http://www.medworm.com/index.php?rid=5286703&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211001340%2Fabstract%3Frss%3Dyes Abstract: The year 2010 marked the 80th anniversary of the first volunteer blood donor panel in Scotland and the 70th anniversary of the first meeting of the Scottish National Blood Transfusion Association – the forerunner of today’s SNBTS. As such the annual Scotblood meeting hosted a distinguished group of speakers to present key note and award lectures on all aspects of Transfusion Medicine including red cell antigens, solving the problems, hazards that shaped our practice, the transfusion needs of patients, donor issues, and component therapy to cellular therapy and beyond. The Iain Cook Memorial Lecture was given by Prof. Dame Marcela Contreras and was entitled “Blood Transfusion International – A Partnership with the Developing World”. (Source: Transfusion and Apheresis Sci... Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5286703 Sat, 01 Oct 2011 04:00:00 +0100 5286703 http://www.medworm.com/index.php?rid=5286702&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211001212%2Fabstract%3Frss%3Dyes By its very nature, the process of apheresis involves the constant use of complex, costly and potentially dangerous medical devices. The process by which we evaluate the safety, efficacy and consistent performance of these devices is know as validation and in its simplicity determines that the equipment is fit for purpose . (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5286702 Sat, 01 Oct 2011 04:00:00 +0100 5286702 http://www.medworm.com/index.php?rid=5286701&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211001364%2Fabstract%3Frss%3Dyes Guest editor for the Listening Post section is Joy Sinclair, RGN. Ms. Sinclair has worked most of her 25years with Oncology and Haematology patients. She holds a Post-Graduate Diploma in Cancer Nursing and is currently Nurse Manager of the Clinical Apheresis Unit in Glasgow, Scotland. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5286701 Sat, 01 Oct 2011 04:00:00 +0100 5286701 http://www.medworm.com/index.php?rid=5286700&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211001200%2Fabstract%3Frss%3Dyes Abstract: The consumption of frozen plasma expressed as a function of consumption of red cells has been used to compare frozen plasma transfusion practices in various countries. This principle has been applied to consumption of frozen plasma in individual hospitals as a potential indicator of the desirability of audit of transfusion practice at the individual hospital level.Wide variation in the relative consumption of frozen plasma has been found both between groups of hospitals determined by size and academic affiliation and within these hospital groupings. Further, there is a close correlation between consumption of frozen plasma in relation to red cell consumption and the annual consumption of frozen plasma in relation to active (acute) treatment beds.It is suggested that high frozen p... Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5286700 Sat, 01 Oct 2011 04:00:00 +0100 5286700 http://www.medworm.com/index.php?rid=5286699&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211001418%2Fabstract%3Frss%3Dyes Conclusions: Autoimmunization to erythrocyte antigens is a frequent complication in patients with β thalassaemia major. Several factors might have contributed to the high autoimmunization rate observed in this study, including non phenotypic blood exposure and alloantibody formation prior to positive Coombs test. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5286699 Sat, 01 Oct 2011 04:00:00 +0100 5286699 http://www.medworm.com/index.php?rid=5286698&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211001431%2Fabstract%3Frss%3Dyes Conclusions: This study showed that anti-HBc positive blood donors may be a source of HBV transmission and further study for evaluation of HBV DNA in anti-HBc positive blood units is needed. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5286698 Sat, 01 Oct 2011 04:00:00 +0100 5286698 http://www.medworm.com/index.php?rid=5286697&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211001297%2Fabstract%3Frss%3Dyes Abstract: The role of plasmapheresis on the treatment of Leptospirosis has not been define, although it has already been used with beneficial effects in the reported case mentioned above, where was possible to contribute to the resolution of the toxic effects on the tubular renal cells. This case report show how plasma exchange prevents the multiorganic failure. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5286697 Sat, 01 Oct 2011 04:00:00 +0100 5286697 http://www.medworm.com/index.php?rid=5286696&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211001224%2Fabstract%3Frss%3Dyes Abstract: Sclerodermatous chronic graft-versus-host disease (cGVHD) following allogeneic hematopoietic stem cell transplantation (HSCT) in children is difficult to treat and life-threatening. Extracorporeal photochemotherapy (ECP; photopheresis), an immunomodulatory therapy that involves the infusion of autologous peripheral blood leukocytes after ex vivo exposure to the photoactive agent 8-methoxypsoralen and ultraviolet A radiation, is an effective treatment for steroid-refractory cGVHD. After undergoing allogeneic HSCT for pre-B-cell acute lymphoblastic leukemia, a 14-year-old boy developed extensive sclerodermatous cGVHD that was refractory to prednisone, tacrolimus, and sirolimus. ECP was administered over the course of 53months, during which the skin softened substantially and immuno... Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5286696 Sat, 01 Oct 2011 04:00:00 +0100 5286696 http://www.medworm.com/index.php?rid=5286695&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211001327%2Fabstract%3Frss%3Dyes We present a case of severe amitriptyline poisoning successfully treated with plasma exchange. Due to high plasma protein binding property of amitriptyline, plasma exchange therapy should be considered in cases of severe amitriptyline intoxication as a life saving therapeutic modality. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5286695 Sat, 01 Oct 2011 04:00:00 +0100 5286695 http://www.medworm.com/index.php?rid=5286694&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211001303%2Fabstract%3Frss%3Dyes Conclusion: The transfusion of I-PLT was associated with a good safety profile and adequate platelet count increments at 1–4h. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5286694 Sat, 01 Oct 2011 04:00:00 +0100 5286694 http://www.medworm.com/index.php?rid=5286693&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211001339%2Fabstract%3Frss%3Dyes Abstract: This retrospective study evaluates changes in transfusion practice and modified blood product utilisation that occurred over the course of eleven years in patients receiving massive transfusion. The mean number of fresh frozen plasma units transfused increased from 9.0±7.9 in 1998 to 11.3±6.7 in 2008 (p=0.03). The mean number of platelet units increased from 1.9±1.3 in 1998 to 2.6±1.7 in 2008 (p=0.02). The proportion of cryoprecipitate increased from 0.03±0.19 in 1998 to 1.3±1.6 in 2008 (p=0.001). Along with these changes was a trend toward decreased mortality (p=0.05). (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5286693 Sat, 01 Oct 2011 04:00:00 +0100 5286693 http://www.medworm.com/index.php?rid=5286692&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211001315%2Fabstract%3Frss%3Dyes Conclusions: The rate of red cell alloimmunization was found to be 9.48% in thalassemics receiving regular transfusions. The incidence of alloantibody development was higher if first transfusion was received at more than 2years of age. Early institution of red cell transfusions and Rh and Kell phenotyping followed by provision of matched blood could prevent alloimmunization. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5286692 Sat, 01 Oct 2011 04:00:00 +0100 5286692 http://www.medworm.com/index.php?rid=5286691&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211000711%2Fabstract%3Frss%3Dyes Abstract: Therapeutic plasma exchange (TPE) is a blood purification method that effectively allows for the removal of waste substances by separating out plasma from other components of blood and the removed plasma is replaced with solutions such as albumin and/or plasma, or crystalloid/colloid solutions. Plasma exchange therapies are becoming increasingly essential, being used in daily practice in critical care settings for various indications, either as a first-line therapeutic intervention or as an adjunct to conventional therapies. This retrospective clinical study analyzes 10-year therapeutic plasma exchange activity experience in an 18-bed ICU at a tertiary care university hospital with a large, critically-ill patient population. Medical records of 1188 plasma exchange procedures on 3... Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5286691 Sat, 01 Oct 2011 04:00:00 +0100 5286691 http://www.medworm.com/index.php?rid=5286690&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211001273%2Fabstract%3Frss%3Dyes Abstract: The patient, who was being followed up for Mantle Cell Lymphoma, was diagnosed with Mast Cell Leukemia 2years after receiving R-CHOP treatment. The results of flow cytometry, which was performed upon determining leucocytosis and detecting blasts in the peripheral smear following the patient’s presentation due to his poor general condition, was consistent with Mantle Cell Leukemia. This case is being presented since there are a very limited number of previously published cases on this topic. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5286690 Sat, 01 Oct 2011 04:00:00 +0100 5286690 http://www.medworm.com/index.php?rid=5286689&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211001285%2Fabstract%3Frss%3Dyes Conclusion: PRP is a novel way to cure the chronic wounds, which can be used as a substitution when a wound goes non-healing and responds badly to the conventional treatments, such as dressing changing and some recombinant growth factors. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5286689 Sat, 01 Oct 2011 04:00:00 +0100 5286689 http://www.medworm.com/index.php?rid=5286688&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211001248%2Fabstract%3Frss%3Dyes Abstract: Thrombotic thrombocytopenic purpura (TTP) is a syndrome with numerous neurological manifestations including altered mental status and seizures . However, status epilepticus (SE) has rarely been reported in this condition . Signs may be transient or fluctuate; however, permanent deficits do occur . Its prognosis was once considered uniformly poor, with a high mortality rate . Since the introduction of plasma infusions and exchanges, the prognosis of the disease has improved dramatically; remissions now occur in 80–90% of patients .Altered mental status in TTP often resolves with plasmapheresis . Likewise, we successfully treated a patient with thrombotic thrombocytopenic purpura (TTP) with pronounced clinical effects of status epilepticus with plasmapheresis and steroid treatmen... Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5286688 Sat, 01 Oct 2011 04:00:00 +0100 5286688 http://www.medworm.com/index.php?rid=5286687&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211001261%2Fabstract%3Frss%3Dyes Abstract: A 20year old woman, admitted with acute pancreatitis, subsequently developed microangiopathic haemolytic anaemia, thrombocytopenia and mild neurological compromise. A diagnosis of thrombotic thrombocytopenic purpura (TTP) was made, and she was treated with plasma exchange leading to complete resolution of this condition. TTP is a rare multisystem disorder which may be life threatening if not treated promptly. The increasing recognition of acute pancreatitis as a potential aetiological factor offers new insights into the pathogenesis, diagnosis and treatment of TTP. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5286687 Sat, 01 Oct 2011 04:00:00 +0100 5286687 http://www.medworm.com/index.php?rid=5286686&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS147305021100125X%2Fabstract%3Frss%3Dyes We report a 35year-old sAA male patient who initially underwent IST using rabbit ATG and Cyclosporine A (CsA). He was supportive transfusion dependent for the whole period of IST-phase. After the second IST-cycle, polymorphonuclear (PMN) cell count increase (>2.0×109/L) was observed, when SC mobilization, two large volume leukapheresis procedures and following autologous transplant were performed.The yields of harvested CD34+ and CD34+/CD90+ cells were 5.75×106/kgbm and 1.7×106/kgbm, respectively. The quantity of applied CD34+ and CD34+/CD90+ cells in autologous SC transplant were 5.45×106/kgbm (7-AADCD34+viability=95.42%) and 1.63×106/kgbm (7-AADCD34+/CD90+viability=95.42%), respectively. Hematopoietic reconstitution registered due to second month after autologous SC transplant and h... Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5286686 Sat, 01 Oct 2011 04:00:00 +0100 5286686 http://www.medworm.com/index.php?rid=5286685&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211001236%2Fabstract%3Frss%3Dyes Conclusion: We determined some differences in phenotype frequencies of blood group compared with other studies. We found higher frequencies of B blood group and also more frequencies of some rare phenotypes, Lu (a−b−), Le (a+b+) and Fy (a−b−). (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5286685 Sat, 01 Oct 2011 04:00:00 +0100 5286685 http://www.medworm.com/index.php?rid=5286684&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211001182%2Fabstract%3Frss%3Dyes Conclusions: Patients with TMA have an increased risk for moderate and severe AE compared to the general apheresis population. Many patients were severely ill at admission. The prognosis is worse if the patient also has a severe chronic disease. Even slightly increased ADAMTS13-antibody titers seem to have a negative impact on the ADAMTS13 levels. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5286684 Sat, 01 Oct 2011 04:00:00 +0100 5286684 http://www.medworm.com/index.php?rid=5286683&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211001194%2Fabstract%3Frss%3Dyes In conclusion TMA is the result of various etiology reasons and pathologic reactions with various clinical entities. It is important to focus on a thorough history including family history when deciding on a diagnosis. Analysis of ADAMTS 13 and ADAMTS 13-antibodies may help to decide continued therapy. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5286683 Sat, 01 Oct 2011 04:00:00 +0100 5286683 http://www.medworm.com/index.php?rid=5286682&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211001406%2Fabstract%3Frss%3Dyes The International Forum section of this issue of Transfusion and Apheresis Science presents a special feature on the World Apheresis Association (WAA) marking the 25th anniversary of the first WAA International Congress. The umbrella organization of the WAA was formed in Dijon, France, in the mid 1980s, and held its first formal meeting, the First International Congress, in Tokyo, Japan May 20–23, 1986. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5286682 Sat, 01 Oct 2011 04:00:00 +0100 5286682 http://www.medworm.com/index.php?rid=5286681&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS147305021100142X%2Fabstract%3Frss%3Dyes This issue of Transfusion and Apheresis Science, brings you a special International Forum, as we are marking the 25th year since the first meeting of the World Apheresis Association. It is introduced by a message from Dr. Robert Weinstein, current WAA. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5286681 Sat, 01 Oct 2011 04:00:00 +0100 5286681 http://www.medworm.com/index.php?rid=5286680&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211001455%2Fabstract%3Frss%3Dyes (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5286680 Sat, 01 Oct 2011 04:00:00 +0100 5286680 http://www.medworm.com/index.php?rid=5210191&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211001054%2Fabstract%3Frss%3Dyes (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5210191 Mon, 01 Aug 2011 04:00:00 +0100 5210191 http://www.medworm.com/index.php?rid=5163514&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211001054%2Fabstract%3Frss%3Dyes (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5163514 Sun, 31 Jul 2011 23:00:00 +0100 5163514 http://www.medworm.com/index.php?rid=5163513&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211000966%2Fabstract%3Frss%3Dyes Abstract: The Scottish National Blood Transfusion Service (SNBTS) originated in Edinburgh in the 1920’s by dentist Jack Copland. Since that time the scope of Transfusion Medicine has broadened significantly to accommodate advances in technologies such as cell isolation, culture and manipulation . Many transfusion services, including SNBTS, now provide expertise both in the traditional field of blood transfusion and the newer, wider field of human cell (including ‘adult’ and embryonic stem cells) and tissue procurement and culture – in all the new science of “regenerative medicine”.This paper describes the importance of Intellectual Property in the provision of Transfusion Medicine today and provides guidance on the management of Intellectual Property so that advances in the fie... Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5163513 Sun, 31 Jul 2011 23:00:00 +0100 5163513 http://www.medworm.com/index.php?rid=5163512&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211000954%2Fabstract%3Frss%3Dyes Abstract: In 1938, the field of Transfusion Medicine began as the simpler entity – Blood Banking. It was a discipline that focused on collecting, processing, storing and distributing end stage blood cells, plasma and plasma fractions to patients. Over the years, the field progressed to include clinical patient services such as apheresis technology and with the development of stem cell transplantation as a standard of care, Cell Therapy. Now the discipline is also finding a niche in the area of Regenerative Medicine. The role played by Transfusion Medicine practitioners in Cell Therapy and Regenerative Medicine was predicated on many factors: (1) pre-existing, established protocols for therapeutic leukapheresis, (2) prior experience with mononuclear cell collection and processing, (3) lon... Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5163512 Sun, 31 Jul 2011 23:00:00 +0100 5163512 http://www.medworm.com/index.php?rid=5163511&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211000942%2Fabstract%3Frss%3Dyes Abstract: Blood transfusion is a mainstay of modern clinical medicine. However, a number of fundamental problems persist, including insufficiency of supply, the threat of transfusion transmissible infectious disease and the problem of immune incompatibility. It would be extremely valuable, therefore, to develop a potentially limitless, infection free, immune neutral source of erythrocytes for transfusion. Human embryonic stem cells (hESC), have potentially limitless proliferative capacity and the potential to differentiate into the majority of adult cell types including erythrocytes. A number of barriers to the development of clinical cellular therapeutics from hESC have been posited, including HLA incompatibility between donor and recipient, difficulties in defining optimal cell phenotype... Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5163511 Sun, 31 Jul 2011 23:00:00 +0100 5163511 http://www.medworm.com/index.php?rid=5163510&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211000930%2Fabstract%3Frss%3Dyes Abstract: A primary function of blood transfusion services is to ensure the safety of the community’s blood supply. Multilayer strategies of safety need to be incorporated into the processing of blood components in order to minimize untoward transfusion events related to infections or the blood storage lesion. While there have been considerable technical advances over the past few decades to advance blood component safety, there is a need for continued improvement.One significant problem area is transfusion transmitted bacterial infections. In infectious disease, blood borne bacteria are the major cause of morbidity in transfusion medicine. Proactive implementation of pathogen inactivation technologies, PIT can help to eliminate bacterial contamination of blood. This is accomplished by i... Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5163510 Sun, 31 Jul 2011 23:00:00 +0100 5163510 http://www.medworm.com/index.php?rid=5163509&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211000929%2Fabstract%3Frss%3Dyes Abstract: Bacteria in transfused platelets can cause serious morbidity and, rarely, death. Most contaminating bacteria enter the blood at the time of venepuncture. While many of these contaminants fail to grow in the platelet unit, storage of platelets at 20–24°C facilitates growth of some organisms, and the cumulative risk of severe sepsis increases with the storage age of platelet components. Several methods have been developed or adapted to attempt to detect contaminating bacteria with high sensitivity and specificity, but the perfect test has yet to be found. Testing early in the platelet component’s shelf life, even using exquisitely sensitive culture-based tests, is compromised by major problems of sample error – there may be too few bacteria present at this stage to ensure th... Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5163509 Sun, 31 Jul 2011 23:00:00 +0100 5163509 http://www.medworm.com/index.php?rid=5163508&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211000917%2Fabstract%3Frss%3Dyes Abstract: During the last decade a number of blood establishments started using molecular methods for typing a subset of their blood donors for minor red cell antigens as a part of their routine work. It can be expected that this development will continue and that DNA testing will take a significant role in future.A sufficient number of antigen-typing in the donor-database allows for the efficient supply of red cell units for patients who carry irregular antibodies directed to red cell antigens. Therefore blood centres often operate antigen typing programs for a subset of their repeat donors. Large-scale donor typing programs are labour-intensive and costly. DNA testing is a feasible alternative to standard serological assays. The most important advantage is the easy access to a spectrum o... Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5163508 Sun, 31 Jul 2011 23:00:00 +0100 5163508 http://www.medworm.com/index.php?rid=5163507&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211000905%2Fabstract%3Frss%3Dyes Abstract: Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is caused by maternal antibodies that cross the placenta in connection with pregnancy and destroy fetal platelets. Recently, maternal T cell responses associated with FNAIT have been studied at the clonal level. These T cell clones recognize an integrin β3 epitope, which is anchored to the HLA-DRB3∗0101-encoded MHC molecule DR52a. The same MHC allele is strongly associated with FNAIT. As the production of pathological antibodies reactive with fetal platelets is likely dependent on these T cell responses, there exists a potential for preventing FNAIT by targeting these T cells. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5163507 Sun, 31 Jul 2011 23:00:00 +0100 5163507 http://www.medworm.com/index.php?rid=5163506&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211000899%2Fabstract%3Frss%3Dyes Abstract: Several miniaturized high throughput technologies have been developed in the last decade, primarily to study genomic structures and gene expression patterns under various conditions. At the same time, the microarrays, biosensors, integrated microfluidic lab-on-a-chip devices, next generation sequencing or digital PCR are gradually finding their diagnostic applications, although their suitability for specialised diagnostic fields has still to be assessed. In this review we discuss the potential applications of the new technologies to blood testing. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5163506 Sun, 31 Jul 2011 23:00:00 +0100 5163506 http://www.medworm.com/index.php?rid=5163505&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211000887%2Fabstract%3Frss%3Dyes This article will explore the impact of these challenges and consider the implications for blood services in the next decade in donor management and recruitment.The authors discuss the major strategic challenges of: (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5163505 Sun, 31 Jul 2011 23:00:00 +0100 5163505 http://www.medworm.com/index.php?rid=5163504&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211000978%2Fabstract%3Frss%3Dyes (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5163504 Sun, 31 Jul 2011 23:00:00 +0100 5163504 http://www.medworm.com/index.php?rid=5163503&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS147305021100098X%2Fabstract%3Frss%3Dyes Dr. Jerard Seghatchian currently serves as a private scientific consultant and advisor internationally in the multi-faceted field of blood banking. He has accumulated four decades of experience in the areas of blood components, apheresis technology, haemostasis, and thrombosis. He has published prolifically on many aspects of maintaining a safe and effective blood supply. He has more than 300 scientific publications and scholarly review papers to his credit and served as the co-editor of five books on various aspects of blood transfusion practice. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5163503 Sun, 31 Jul 2011 23:00:00 +0100 5163503 http://www.medworm.com/index.php?rid=5163502&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211000991%2Fabstract%3Frss%3Dyes These theme articles have been planned and assembled by Dr. Hagop Bessos and me, two close friends and colleagues, who have collaborated together in the past on the development of new generation molecular markers for storage lesion of platelets and red cells; published papers on these and other subjects; and co-chaired bi-annual blood components special interest group meetings of the British Blood Transfusion Society for almost a decade. We currently publish annual reports on Scotblood conferences in the journal of transfusion and apheresis science (TRASCI) making the contents of these conferences available to broader groups of readers of the journal. As the invited guest editor of this theme section, I would like to dedicate the section to my co-editor Dr. Hagop Bessos (from the Scottish ... Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5163502 Sun, 31 Jul 2011 23:00:00 +0100 5163502 http://www.medworm.com/index.php?rid=5163501&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211001042%2Fabstract%3Frss%3Dyes In this study we aim to investigate the incidence of PTR and potential risks in patients undergoing hematopoietic stem cell transplantation (HSCT).Method: A total of 69 HSCT patients were involved with their basic characteristics recorded. PTR was identified by 24h corrected count increment (24h-CCI) post platelet transfusion and we transformed it to the corrected platelet increment (CPI), which was compared between the PTR and non PTR groups. Age, gender, ABO incompatibility, disease and CPI were analyzed by Logistic regression analysis for PTR incidence. We searched our medical records to find possible risks of PTR with different levels of CPI.Results: There was no significant difference of platelet engraftment (PE) (P=0.271) and platelet requirement (PR) (P=0.333) between patients with ... Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5163501 Sun, 31 Jul 2011 23:00:00 +0100 5163501 http://www.medworm.com/index.php?rid=5163500&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211001030%2Fabstract%3Frss%3Dyes Abstract: Acute myeloid leukemia (AML) is malignant tumor of haemopoietic precursor cells of non-lymphoid lineage. AML can atypically present with non-spesific cutaneous lesions or wounds. There are rare acute leukemia cases which present with genital ulcerations or pyoderma gangrenosum in the literature. The effect of acute leukemia on wound healing is not known, but it is thought that cytopenias and chemotherapy can impair wound healing in patients with leukemia. The effects of chemotherapeutic agents on wound healing are arguable. Here we present wound care strategies and simultaneously applied chemotherapy in an AML patient. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5163500 Sun, 31 Jul 2011 23:00:00 +0100 5163500 http://www.medworm.com/index.php?rid=5163499&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211001029%2Fabstract%3Frss%3Dyes Abstract: We retrospectively reviewed peripheral blood stem cell (PBSCs) collections following 528 mobilization cycles over a 10-year period. A total of 206 (13.1%) AEs occurred in association with the 1572 procedures. One hundred and ninety-one (12.15%) of the AEs were classified as clinical AEs and 15 (0.95%) were classified as apheresis instrument related AEs. The most common clinical AE was numbness of the lips, tongue, or extremities (161 procedures, 10.2%) related to the infusion of acid citrate dextrose-A (ACD). Multivariate analysis revealed high amounts of ACD/weight (odds ratio [OR]=1.11, p=0.009), high numbers of procedures (OR=1.33, p (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5163499 Sun, 31 Jul 2011 23:00:00 +0100 5163499 http://www.medworm.com/index.php?rid=5163498&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211001017%2Fabstract%3Frss%3Dyes We report the case of a 36-year old pregnant woman with a Kell alloimmunization (anti-K1), probably secondary to a previous blood transfusion, and a severe hemolytic disease of the fetus. Once the first fetal blood transfusion by cordocentesis was performed, we started treatment with repeated plasmapheresis to maintain anti-K1 titer below 1:32. With this scheme we did not need to perform a second intrauterine fetal blood transfusion and only mild anemia was found in the newborn. Taking into account that the rate of serious complications with plasmapheresis is lower than that related with intrauterine blood transfusion, this could be an alternative approach to repeated transfusions. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5163498 Sun, 31 Jul 2011 23:00:00 +0100 5163498 http://www.medworm.com/index.php?rid=5163497&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211001005%2Fabstract%3Frss%3Dyes Conclusions: The decision to submit the patient with clinical evidence of HP caused by SHTG to apheresis was correct. The improvement in the clinical picture was fast and the recovery was complete. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5163497 Sun, 31 Jul 2011 23:00:00 +0100 5163497 http://www.medworm.com/index.php?rid=5163496&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211001066%2Fabstract%3Frss%3Dyes I am delighted to introduce two new Editorial Board members for Transfusion and Apheresis Science. We are honoured to welcome to our board, Dr. Kenneth E. Nollet, M.D., Ph.D., Department of Blood Transfusion and Transplantation Immunology, Specially Appointed Professor, Fukushima Medical University, Fukushima City, Japan; and Dr. Valery Leytin, Ph.D., Staff Scientist, Li Ka Shing Knowledge Institute (LKSKI) of St. Michael’s Hospital, Toronto, and Associate Professor in the Laboratory Medicine and Pathobiology, and Medicine Departments, University of Toronto, Ontario, Canada. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5163496 Sun, 31 Jul 2011 23:00:00 +0100 5163496 http://www.medworm.com/index.php?rid=5163495&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS147305021100108X%2Fabstract%3Frss%3Dyes (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5163495 Sun, 31 Jul 2011 23:00:00 +0100 5163495 http://www.medworm.com/index.php?rid=5110583&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211000735%2Fabstract%3Frss%3Dyes (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=5110583 Tue, 31 May 2011 23:00:00 +0100 5110583 http://www.medworm.com/index.php?rid=4923946&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211000735%2Fabstract%3Frss%3Dyes (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4923946 Tue, 31 May 2011 23:00:00 +0100 4923946 http://www.medworm.com/index.php?rid=4923945&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211000656%2Fabstract%3Frss%3Dyes The nurse lead photopheresis unit at Rotherham General Hospital in the UK has been operating since 1994 and recently became a Centre of Excellence. It accepts referrals from Yorkshire, Scotland, Birmingham, Leeds and Manchester. Patients at the Rotherham photopheresis unit are primarily treated for steroid refractory Chronic Graft versus Host Disease (CGvHD) and Cutaneous T-cell Lymphoma (CTCL). The treatment received is Extracorporeal Photopheresis (ECP). This unit has been involved in research programmes lead by the consultant haematologist, from which data on the positive effect of ECP on patients with CGvHD has been identified. Data on CTCL has still to be formally presented. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4923945 Tue, 31 May 2011 23:00:00 +0100 4923945 http://www.medworm.com/index.php?rid=4923944&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211000644%2Fabstract%3Frss%3Dyes Guest Editor for the Listening Post section is Joy Sinclair, RGN. Ms. Sinclair has worked most of her 25years with Oncology and Haematology patients. She holds a Post-Graduate Diploma in Cancer Nursing and is currently Nurse Manager of the Clinical Apheresis Unit in Glasgow, Scotland. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4923944 Tue, 31 May 2011 23:00:00 +0100 4923944 http://www.medworm.com/index.php?rid=4923943&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211000723%2Fabstract%3Frss%3Dyes (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4923943 Tue, 31 May 2011 23:00:00 +0100 4923943 http://www.medworm.com/index.php?rid=4923942&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211000632%2Fabstract%3Frss%3Dyes Abstract: Platelet storage lesion (PSL), correlating with reduced in vivo recovery/survival and hemostatic capacity after transfusion, is characterized essentially by morphological and molecular evidence of platelet activation and energy consumption in the medium. Processes that limit shelf-life are multifactorial, and include both necrosis and apoptosis. PSL is greatly influenced by factors including duration of storage, temperature, ratio of platelet number to media volume, solution composition with respect to energy content and buffering capacity, and gas permeability of the container. Recent progress for slowing PSL has been made with storage media that more effectively fuel ATP production and buffer the inevitable effects of metabolism. Improved oxygen-permeability of containers also ... Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4923942 Tue, 31 May 2011 23:00:00 +0100 4923942 http://www.medworm.com/index.php?rid=4923940&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211000619%2Fabstract%3Frss%3Dyes Abstract: Platelets (PLTs), play a key role in hemostasis, clot stability and retraction as well as in vascular repair and anti-microbial host defense. Upon vessel wall damage, PLTs undergo a highly regulated set including adhesion, spreading, aggregation, release reactions as well as exposure of procoagulant surfaces to rapidly form a hemostatic plug that occludes the site of damage. When PLT function is impaired, the bleeding risk increases, but (hyperreactive) PLTs are also involved in many pathophysiological events like thrombosis, vessel constriction, atherogenesis, tumor growth and metastasis, inflammation including atherosclerosis and the subsequent formation of arterial thrombi resulting in stroke and myocardial infarction.While hereditary PLT function disorders are very rare, acqu... Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4923940 Tue, 31 May 2011 23:00:00 +0100 4923940 http://www.medworm.com/index.php?rid=4923939&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211000607%2Fabstract%3Frss%3Dyes Abstract: For platelets to maintain their in vitro quality and in vivo effectiveness, they need to be stored at room temperature with gentle agitation in gas-permeable containers. The mode of agitation affects the quality of the platelets, and a gentle method of agitation, either a circular or a flat bed movement, provides the best results. Tumblers or elliptical agitators induce platelet activation and subsequent damage. As long as the platelets remain in suspension, the agitation speed is not important. Agitation of the platelet concentrates ensures that the platelets are continuously oxygenated, that sufficient oxygen can enter the storage container and that excess carbon dioxide can be expelled. During transportation of platelet concentrates, nowadays over long distances where they are... Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4923939 Tue, 31 May 2011 23:00:00 +0100 4923939 http://www.medworm.com/index.php?rid=4923938&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211000589%2Fabstract%3Frss%3Dyes Abstract: The metabolic conversion of glucose to energy and reducing power by platelets is examined. Although platelets concurrently metabolize glucose aerobically and anaerobically, the balance between the cytosolic and mitochondrial pathways is affected not only by physiological activation but also by conditions prevailing during in vitro storage. The development of platelet additive solutions and pathogen reduction technologies point to increased glucose metabolism and consequent high levels of lactate production as the effect of platelet damage, rather than the cause. Consequently a different perspective of the data suggests that reduction rather than support of platelet metabolism in vitro would result in a better quality of stored platelets. (Source: Transfusion and Apheresis Science... Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4923938 Tue, 31 May 2011 23:00:00 +0100 4923938 http://www.medworm.com/index.php?rid=4923937&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211000577%2Fabstract%3Frss%3Dyes This report considers the electrolytic composition of previously described platelet additive solutions, in order to draw general conclusions about what is required for platelet function and longevity. The optimal concentrations of Na+ and Cl− are 69–115mM. The presence of both K+ and Mg2+ in platelet suspension at nearly physiological concentrations (3–5mM and 1.5–3mM, respectively) is indispensable for good preservation capacity because both electrolytes are required to prevent platelet activation. In contrast to K+ and Mg2+, Ca2+ may not be important because no free Ca2+ is available in M-sol, which showed excellent platelet preservation capacity at less than 5% plasma concentration. The importance of bicarbonate (approximately 40mM) can be recognized when the platelets are suspe... Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4923937 Tue, 31 May 2011 23:00:00 +0100 4923937 http://www.medworm.com/index.php?rid=4923936&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211000590%2Fabstract%3Frss%3Dyes Abstract: Single-donor hyperconcentrated plateletapheresis (dry-platelets) collection has been introduced in the 90’s as a part of the newly developed multi-component collection strategy. This approach allowed to safely collect multiple components from a single apheresis donation, i.e. RBC, FFP and/or plateletpheresis units. Dry-platelets are usually resuspended in additive solution to maintain an adequate pH during the storage period until use.Some concern existed about possible higher degrees of platelet activation in dry-platelets units when compared to standard concentration (1.0–1.6×106/μL platelets) units and its possible correlation with lower in vivo efficiency and/or survival of the former units. Several authors investigated this specific issue, and dry-platelets units prove... Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4923936 Tue, 31 May 2011 23:00:00 +0100 4923936 http://www.medworm.com/index.php?rid=4923935&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211000565%2Fabstract%3Frss%3Dyes (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4923935 Tue, 31 May 2011 23:00:00 +0100 4923935 http://www.medworm.com/index.php?rid=4923934&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211000620%2Fabstract%3Frss%3Dyes Platelet preservation, the special theme of this issue, has been wisely chosen by the permanent editorial staff of Transfusion and Apheresis Science. How to collect, process, and preserve a safe and stable supply of platelets has long been a concern in our specialty, and recent developments have made these matters even more important. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4923934 Tue, 31 May 2011 23:00:00 +0100 4923934 http://www.medworm.com/index.php?rid=4923933&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211000668%2Fabstract%3Frss%3Dyes Abstract: As the first step of UCB banking, UCB collection has an important role in banking procedures. The aim of this study was to reveal the current status of UCB collection and discuss the management of the UCB bank. We conducted a questionnaire survey at medical centers collecting UCB, followed by semi-structured interviews with some respondents. Out of 38 institutes, 11 respondents (28.9%) thought that collection of UCB in addition to their routine medical services puts a burden on physicians. The obstetricians involved in the UCB collection are generally willing to participate in the procedure under current circumstances at medical institutes. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4923933 Tue, 31 May 2011 23:00:00 +0100 4923933 http://www.medworm.com/index.php?rid=4923932&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS147305021100067X%2Fabstract%3Frss%3Dyes Abstract: The likelihood of survival in cases of postpartum hemolytic uraemic syndrome (HUS) is as high as 80–90% with early diagnosis and aggressive treatment using plasma exchange (PE). The patients, referred to our center, diagnosed as postpartum HUS presented with thrombocytopenia, microangiopathic hemolytic anaemia with or without fever and severe renal failure, were managed aggressively with PE in conjunction with hemodialysis. All patients showed clinical improvement, along with laboratory indicators like normal renal function tests, increased platelet counts and decreased lactic dehydrogenase levels. Awareness amongst treating physicians, early diagnosis and treatment with PE could be the key factors in reducing maternal mortality due to postpartum HUS in developing countries. (S... Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4923932 Tue, 31 May 2011 23:00:00 +0100 4923932 http://www.medworm.com/index.php?rid=4923931&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211000681%2Fabstract%3Frss%3Dyes Abstract: Unmanipulated HLA-haploidentical/mismatch related transplantation with combined granulocyte-colony stimulating factor-mobilized peripheral blood stem cells (G-PBSCs) and granulocyte-colony stimulating factor-mobilized bone marrow (G-BM) has been used as an alternative transplantation strategy for patients without an HLA-matched donor. In this transplantation setting, factors associated with hematopoietic recovery have not been defined completely. The aim of this study was to investigate the factors influencing the engraftment in this transplantation setting for patients with leukemia. The study group comprised 104 patients with leukemia who underwent transplantation at a single institution between 2005 and 2008. Factors correlating with neutrophil and platelet engraftment post-tr... Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4923931 Tue, 31 May 2011 23:00:00 +0100 4923931 http://www.medworm.com/index.php?rid=4923930&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211000693%2Fabstract%3Frss%3Dyes Conclusions: We emphasize the need for prompt and sufficient calcium replacement, monitored by serum ionized calcium levels, in the early post-cardiac transplantation period when plasma exchange is performed with thawed fresh frozen plasma replacement. The persistently low serum calcium levels we observed post heart transplantation were possibly contributed to by increased myocardial calcium influx. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4923930 Tue, 31 May 2011 23:00:00 +0100 4923930 http://www.medworm.com/index.php?rid=4923929&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS147305021100070X%2Fabstract%3Frss%3Dyes Conclusions: Both higher and earlier responses obtained with high dose steroid may be significant in reducing hospitalization period of patients and eliminating life-threatening platelet values within the shortest time possible. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4923929 Tue, 31 May 2011 23:00:00 +0100 4923929 http://www.medworm.com/index.php?rid=4923928&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211000747%2Fabstract%3Frss%3Dyes I am pleased to announce that Transfusion and Apheresis Science is now accepting manuscripts through a new electronic submission system available on our website: http://ees.elsevier.com/trasci/ to better facilitate our commitment to bring comprehensive and up-to-date information to physicians and health care professionals involved in the rapidly changing fields of Transfusion Medicine and Apheresis Science. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4923928 Tue, 31 May 2011 23:00:00 +0100 4923928 http://www.medworm.com/index.php?rid=4923927&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211000760%2Fabstract%3Frss%3Dyes (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4923927 Tue, 31 May 2011 23:00:00 +0100 4923927 http://www.medworm.com/index.php?rid=4596565&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211000383%2Fabstract%3Frss%3Dyes (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4596565 Wed, 16 Mar 2011 17:37:44 +0100 4596565 http://www.medworm.com/index.php?rid=4596564&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211000371%2Fabstract%3Frss%3Dyes Abstract: Remarkable technological advances and increased awareness have both contributed to decrease substantially the uncertainty of the analytical phase, so that the manually intensive preanalytical activities currently represent the leading sources of errors in laboratory and transfusion medicine. Among preanalytical errors, misidentification and mistransfusion are still regarded as a considerable problem, posing serious risks for patient health and carrying huge expenses for the healthcare system. As such, a reliable policy of risk management should be readily implemented, developing through a multifaceted approach to prevent or limit the adverse outcomes related to transfusion reactions from blood incompatibility. This strategy encompasses root cause analysis, compliance with accredi... Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4596564 Wed, 16 Mar 2011 17:37:44 +0100 4596564 http://www.medworm.com/index.php?rid=4596563&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211000346%2Fabstract%3Frss%3Dyes Abstract: The novel agents including thalidomide, bortezomib and lenalidomide have been incorporated into combination regimens which are moving from the advanced/refractory setting to first-line treatment. For the majority of elderly patients, the following regimens are considered standard: melphalan+prednisone in combination with bortezomib or thalidomide and the combination of lenalidomide+low-dose dex. For transplant-eligible patients novel agents are included in the induction phase before and in the consolidation/maintenance phase after transplant. In the relapsed/refractory setting, combinations of novel agents generate the best results but cumulative toxicity is limiting. Several newer agents such as carfilzomib, pomalidomide and deacetylase inhibitors are entering phase II and III c... Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4596563 Wed, 16 Mar 2011 17:37:44 +0100 4596563 http://www.medworm.com/index.php?rid=4596562&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211000334%2Fabstract%3Frss%3Dyes Abstract: The definition of ‘atypical MPDs’ includes all chronic myeloid disorders that defy classification as either MDS or classic MPDs. These can be both molecularly defined or clinicopathologically assigned: chronic myelomonocytic leukemia, juvenile myelomonocytic leukemia, chronic neutrophilic leukemia, chronic basophilic leukemia, chronic eosinophilic leukemia, idiopathic eosinophilia including hypereosinophilic syndrome, systemic mastocytosis, unclassified MPD, and eosinophilic/mast cell disorders associated with mutations of PDGFR, FGFR1, and KIT all fall under the category of atypical MPDs. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4596562 Wed, 16 Mar 2011 17:37:44 +0100 4596562 http://www.medworm.com/index.php?rid=4596561&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211000358%2Fabstract%3Frss%3Dyes Abstract: Allogeneic hematopoietic stem cell transplantation (HSCT) following myeloablative (conventional) conditioning regimen is associated with a high incidence of transplant-related morbidity and mortality, limiting its use to younger patients without medical co-morbidities. Over the past few years, it has become more evident that the alloreactivity of transplanted donor immunocompetent cells against host tumor cells (graft-versus-tumor effects, GVT effects) plays a major role in eradicating malignancies after allogeneic HSCT. Based on these observations, several groups of investigators have developed reduced intensity conditioning (RIC) regimens allowing patients who are ineligible for conventional HSCT to benefit from the potentially curative GVT effects of allogeneic transplantation... Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4596561 Wed, 16 Mar 2011 17:37:44 +0100 4596561 http://www.medworm.com/index.php?rid=4596560&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211000322%2Fabstract%3Frss%3Dyes Abstract: Acute lymphoblastic leukemia remains a challenging disease in adults. With modern multi-drug induction chemotherapy regimens, complete remission can be achieved in most patients. However, without additional therapy at the time of the first remission, most patients will eventually relapse. Regardless of the treatment option chosen at the time of relapse, outcomes after relapse are poor, with only around 10% of all patients surviving after relapse. Thus, decision-making at the time of achieving the first complete remission is critical. Allogeneic stem cell transplantation is highly effective at preventing relapse, but with significant treatment related toxicity. Ongoing chemotherapy in the form of consolidation and maintenance may be less effective at preventing relapse, but with l... Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4596560 Wed, 16 Mar 2011 17:37:44 +0100 4596560 http://www.medworm.com/index.php?rid=4596559&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211000243%2Fabstract%3Frss%3Dyes The major role that human leukocyte antigens (HLA) have played in solid organ transplantation cannot be denied especially here in Cape Town, the home of the first heart transplant. However, this is now paralleled if not eclipsed by the role of HLA in haematopoietic stem cell transplantation. Such stem cell transplants can cure patients with malignant and non-malignant haematological disease. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4596559 Wed, 16 Mar 2011 17:37:44 +0100 4596559 http://www.medworm.com/index.php?rid=4596558&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS147305021100036X%2Fabstract%3Frss%3Dyes Conclusions: The HIV infection worsens significantly the prognosis of children with BL, in spite of anti-retroviral and cytostatic treatment. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4596558 Wed, 16 Mar 2011 17:37:44 +0100 4596558 http://www.medworm.com/index.php?rid=4596557&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211000255%2Fabstract%3Frss%3Dyes Abstract: Acute lymphoblastic leukemia is a heterogeneous disease comprising several clinico-biological entities. Karyotyping of leukemic cells identifies recurrent chromosome rearrangements. These are usually translocations that activate genes encoding transcription factor regulating B- or T-cell differentiation. Gene expression-array confirms the prognostic relevance of ALL subgroups identified by specific chromosomal rearrangements and isolates new subgroups. Analysis of genomic copy number changes and high throughput sequencing reveal new cryptic deletions.The challenge is now to understand how these cooperative genetic lesions interact in order to have the molecular rationales needed to select new therapeutic targets and to develop and combine inhibitors with high levels of anti-leuke... Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4596557 Wed, 16 Mar 2011 17:37:44 +0100 4596557 http://www.medworm.com/index.php?rid=4596556&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211000292%2Fabstract%3Frss%3Dyes Abstract: The outcome for patients with diffuse large B-cell lymphomas improved dramatically in the last decade, and the opportunity for improving therapy for patients with peripheral T-cell lymphoma exists as we begin to study specific subtypes of the disease. It is entirely possible that patients with different genetic subtypes of diffuse large B-cell lymphoma will eventually require different treatments, and the same will be true for patients with subtypes of peripheral T-cell lymphoma. These possibilities will be the focus of clinical investigation over the next decade. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4596556 Wed, 16 Mar 2011 17:37:44 +0100 4596556 http://www.medworm.com/index.php?rid=4596555&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211000310%2Fabstract%3Frss%3Dyes Abstract: Therapeutic monoclonal antibodies (MoAbs) have been the major breakthrough in the treatment of both indolent and aggressive B-cell non-Hodgkin’s lymphoma (NHL), and have become standard of care for these diseases. However, patients may not respond to antibody therapy, or resistance can develop. Radioimmunotherapy (RIT) makes use of continuous low dose radiation emitted by radioisotopes targeted directly to the lymphoma cells. Both the 131I-labeled murine CD20 MoAb tositumomab (Bexxar®) and 90Y-labeled ibritumomab-tiuxetan (Zevalin®) have been shown to be more effective than unlabeled MoAbs in terms of overall and complete response rates in follicular lymphoma (FL) patients, and both agents have a high response rate even in rituximab-resistant patients. Long-term responses, es... Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4596555 Wed, 16 Mar 2011 17:37:44 +0100 4596555 http://www.medworm.com/index.php?rid=4596554&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211000309%2Fabstract%3Frss%3Dyes Abstract: Positron emission tomography (PET) with [F-18]-fluoro-deoxy-glucose (FDG) has a well established and growing role in the management of most lymphomas. The interpretation of FDG PET scans in HIV positive patients is however challenging. This is largely due to scan changes giving a higher likelihood of false positive studies from both the direct effects of HIV and its treatment, and related to secondary HIV-related pathology. There is currently a need for further clinical research to evaluate to contribution of FDG PET in the management of HIV positive patients with lymphoma. In this paper existing studies related to FDG PET scanning in HIV positive patients will be reviewed, and potential pitfalls will be identified. These pitfalls can be avoided to some extent by the interpreter ... Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4596554 Wed, 16 Mar 2011 17:37:43 +0100 4596554 http://www.medworm.com/index.php?rid=4596553&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211000231%2Fabstract%3Frss%3Dyes This study is designed to qualify and establish the impact of HIV epidemic and the ARV roll-out treatment program on the incidence of HIV Related Lymphoma (HRL). Early data document that despite the ART roll out, cases of HRL are increasing in this geographical location, now accounting for 37% of all lymphomas seen in 2009 which is an increase from 5% in 2002. This is in contrast to trends seen in developed environments following the introduction of ART. Also noted are the emergence of subtypes not previously seen in this location such as Burkitt and plasmablastic lymphomas. Burkitt lymphoma is now the commonest HRL seen in this population followed by diffuse large B-cell lymphoma subtypes. The reasons for this observed increase in HRL are not ascribable to improved diagnostic capacity as ... Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4596553 Wed, 16 Mar 2011 17:37:43 +0100 4596553 http://www.medworm.com/index.php?rid=4596552&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211000267%2Fabstract%3Frss%3Dyes Abstract: Undoubtedly the most important event in the previous decade in lymphoma treatment was the establishment of immunotherapy as a prime modality. Addition of rituximab improves survival in almost every group of patients with CD20+ tumors. This has led to the appearance of a number of “me too” monoclonal antibodies (MoAbs) as well as MoAbs directed against other antigens whose usefulness remains to be proven during the next decade. We have also seen the raise and, probably unwarranted, fall of radioimmunotherapy. Conventional radiotherapy is losing ground.Regarding chemotherapy, the success of attempts to supplant R-CHOP-21 for front-line treatment of DLBCL with more dose-dense or dose-intense regimens remains doubtful and this issue is still unresolved. Bendamustine appeared as p... Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4596552 Wed, 16 Mar 2011 17:37:43 +0100 4596552 http://www.medworm.com/index.php?rid=4596551&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211000280%2Fabstract%3Frss%3Dyes (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4596551 Wed, 16 Mar 2011 17:37:43 +0100 4596551 http://www.medworm.com/index.php?rid=4596550&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211000279%2Fabstract%3Frss%3Dyes Historically the creation, followed by a registration, of this group was the brainchild of the late Professor Geoffrey Falkson, Professor Werner Bezwoda and Professor Peter Jacobs nearly three decades ago. The impetus was considerable confusion, both locally and internationally at that time, surrounding these lymphoreticular malignancies particularly in terms of diagnosis. Similarly little was known about pathophysiology and treatment options were, understandably, poorly standardised. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4596550 Wed, 16 Mar 2011 17:37:43 +0100 4596550 http://www.medworm.com/index.php?rid=4596549&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211000218%2Fabstract%3Frss%3Dyes Abstract: Large-volume leukapheresis (LVL) differs from standard leukapheresis by increased blood flow and an altered anticoagulation regimen. An open issue is to what degree a further increase in processed blood volume is reasonable in terms of higher yields and safety. In 30 LVL performed in patients with hematologic malignancies, 6 total blood volumes were processed. LVL resulted in a higher CD34+ cell yield without a change in graft quality. Although a marked platelet decrease can be expected, LVL is safe and can be recommended as the standard procedure for patients who mobilize low numbers of CD34+ cells and when high number of CD34+ cells are required. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4596549 Wed, 16 Mar 2011 17:37:43 +0100 4596549 http://www.medworm.com/index.php?rid=4596548&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211000188%2Fabstract%3Frss%3Dyes Abstract: Orbital lymphoma is a very rare type of primary Non-Hodgkin lymphoma. The disorder is often small B-cell lymphoma, although large cell morphology may also be identified in rare cases. It may sometimes be confused with non-malignant, benign-course lymphoid hyperplasia. Although involvement is usually unilateral (80%), bilateral cases are also reported. Response to radiotherapy is achieved in the majority of cases, whereas the prognosis is poor in orbital involvement with large cell lymphoma and response to combined chemotherapy is inadequate. In this paper, we report a case with a diagnosis of unilateral adnexal involvement, who previously received CHOP treatment and developed a relapse 6months later, then responded to treatment with Rituximab. (Source: Transfusion and Apheresis S... Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4596548 Wed, 16 Mar 2011 17:37:43 +0100 4596548 http://www.medworm.com/index.php?rid=4596547&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211000206%2Fabstract%3Frss%3Dyes Abstract: Hemorrhage is a frequent cause of death in hematologic patients. Factors influencing its occurrence are still not precisely defined. Hence, the objectives of this report were to define these factors in a group of patients suffering from severe (WHO grades 3 and 4) hemorrhage, hospitalized in the Department of Hematology, Oncology and Internal Medicine, The Medical University of Warsaw, Poland. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4596547 Wed, 16 Mar 2011 17:37:43 +0100 4596547 http://www.medworm.com/index.php?rid=4596546&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS147305021100022X%2Fabstract%3Frss%3Dyes We report on a patient undergoing major ABO incompatible allogeneic HSCT (donor/recipient: A/O) whose blood group was wrongly established to have completely switched to blood group A when using a routine tube method and micro gel column blood grouping card on the 68th day post transplantation. The major crossmatch test with added antiglobulin and blood group A red cells was still positive. After further investigation, an explanation was found because we could not detect IgG anti-A in the serum. At the same time, anti-A coated the patient’s RBCs and could be identified using a heat elution method although the DAT was negative. We also found an obvious mixed field with the LISS-IAT gel card. Hence, routine methods of ABO grouping are unfit for ABO incompatible allogeneic HSCT patients and ... Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4596546 Wed, 16 Mar 2011 17:37:43 +0100 4596546 http://www.medworm.com/index.php?rid=4596545&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS147305021100019X%2Fabstract%3Frss%3Dyes Conclusion: The trend of indications in our center is comparable to international data. However, the average number of procedures in our population is lower than world statistics and the method of plasma exchange has not been modified. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4596545 Wed, 16 Mar 2011 17:37:43 +0100 4596545 http://www.medworm.com/index.php?rid=4596544&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211000176%2Fabstract%3Frss%3Dyes Abstract: We conducted a multicenter study to investigate the efficacy of leukocytapheresis (LCAP) without concomitant steroid therapy in active ulcerative colitis (UC) patients. Twenty patients were enrolled. LCAP was performed twice a week for 3weeks. The results revealed a significant decrease of the Lichtiger’s clinical activity index (CAI) from 11.7±2.6 at baseline to 6.6±4.1 after the therapy. The endoscopic index and serum C-reactive protein levels also decreased significantly after the therapy. Of the 20 patients, 15 (75%) were assessed as responders (CAI⩽4 or ΔCAI⩾3), and 7 (35%) achieved complete remission (CAI⩽4). No serious adverse reactions were encountered. The results suggest that LCAP is an effective and safe option for patients with active UC who had not receive... Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4596544 Wed, 16 Mar 2011 17:37:43 +0100 4596544 http://www.medworm.com/index.php?rid=4596543&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211000395%2Fabstract%3Frss%3Dyes Our second issue of 2011 is substantial to be sure, with submitted papers from Japan, Iran, PR China, Poland, Turkey, and Croatia. A very interesting paper by Ashida et al. suggests that, according to the results of a multicentre study, leukocytapheresis is an effective and safe option for patients with active ulcerative colitis who had not received systemic steroid treatment. Drozd-Sokolowska et al. explore factors influencing the risk of severe (WHO Grade 3 and 4) hemorrhage as a frequent cause of death in hematologic patients. Their analytical evaluation of hospital records, to identify cases and to evaluate the circumstances of life-threatening hemorrhage of a large hematology ward, form the basis of their report. Bilgir et al., report on a case of orbital lymphoma with a diagnosis of... Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4596543 Wed, 16 Mar 2011 17:37:43 +0100 4596543 http://www.medworm.com/index.php?rid=4596542&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050211000413%2Fabstract%3Frss%3Dyes (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4596542 Wed, 16 Mar 2011 17:37:43 +0100 4596542 http://www.medworm.com/index.php?rid=4204234&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050210001953%2Fabstract%3Frss%3Dyes Abstract: It is an important goal in transfusion practice to improve the quality and safety of platelet transfusions. Accordingly, blood services have implemented several complimentary measures such as continual improvement in donor selection, donor testing, newer development in collection/processing, including the diversion of the first part of collection to reduce the potential risk of bacterial contamination and the use of various platelet additive solutions and reduction in donor exposures through production multiple doses by apheresis procedures. Unfortunately despite considerable improvement in blood components safety bacterial transmission by platelet transfusion remains the major microbial cause of morbidity and mortality in transfusion medicine. Currently two major interventions a... Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4204234 Sat, 27 Nov 2010 05:30:09 +0100 4204234 http://www.medworm.com/index.php?rid=4204233&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050210001485%2Fabstract%3Frss%3Dyes Abstract: An analysis of adverse reactions caused by single-donor fresh frozen plasma (FFP) and pooled (solvent/detergent) S/D-treated plasma reveals that these plasma products are significantly different. We are unaware of any reports associating pooled S/D-treated plasma with transfusion-associated acute lung injury, or post-transfusion-thrombocytopenia. In contrast, each of these transfusion reactions is a well-recognized adverse effect of single-donor FFP. Pooled S/D-treated plasma also has a more favorable clinical profile with reference to common acute reactions, such as fever, chills, and allergic reactions, which occur less frequently compared to single-donor FFP. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4204233 Sat, 27 Nov 2010 05:30:09 +0100 4204233 http://www.medworm.com/index.php?rid=4204232&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050210001461%2Fabstract%3Frss%3Dyes Conclusion: The initiative from the blood bank, i.e., transfusion packages for patients with uncontrollable bleeding and based on the thromboelastogram when hemodynamic control is established, has improved the transfusion practice and survival in massively transfused patients at our hospital. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4204232 Sat, 27 Nov 2010 05:30:09 +0100 4204232 http://www.medworm.com/index.php?rid=4204231&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050210001503%2Fabstract%3Frss%3Dyes Abstract: Efforts to reduce the risk of transfusion-transmitted infectious diseases began more than 4 decades ago with testing donated blood for syphilis. During the subsequent 4 decades, the number of recognized blood-borne transmissible agents and new laboratory tests has proliferated to a logistical breaking point. Further, the number of “emerging agents” which might enter the donor population is increasing continuously. In the search for an alternative to the laboratory testing strategy, pathogen-reduction technologies have emerged as the most promising. The model for this paradigm is pasteurization of a bottle of cow’s milk. No matter what infective agent may be present in freshly collected cow’s milk, pasteurization, i.e., a generic purification process can eliminate all pote... Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4204231 Sat, 27 Nov 2010 05:30:09 +0100 4204231 http://www.medworm.com/index.php?rid=4204230&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050210001473%2Fabstract%3Frss%3Dyes Abstract: Various experimental studies have shown infectivity in blood in relation to bovine spongiform encephalitis (BSE) and variant Creutzfeldt–Jakob disease (vCJD). Human to human transmission vCJD infection has been reported via transfusion of non-leukocyte-reduced red cells and, probably, via factor VIII concentrates. A number of precautionary measures are in place but uncertainties remain, especially concerning the number of BSE-infected people in the population. Additional measures such as prion filtration need consideration. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4204230 Sat, 27 Nov 2010 05:30:09 +0100 4204230 http://www.medworm.com/index.php?rid=4204229&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050210001497%2Fabstract%3Frss%3Dyes This article will give an overview of non-infectious side-effects associated with plasma transfusion by dividing them into two categories: hazards associated with the donor or the processing of blood, which will be attributed to as blood safety; and hazards which are associated with the clinical use of plasma, attributed to as transfusion safety. After having installed preventive measures against TRALI in most countries, blood safety is about to reach a very high level for plasma. In contrast, transfusion safety will remain a relevant issue for the next decade of plasma therapy. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4204229 Sat, 27 Nov 2010 05:30:08 +0100 4204229 http://www.medworm.com/index.php?rid=4204228&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050210001515%2Fabstract%3Frss%3Dyes (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4204228 Sat, 27 Nov 2010 05:30:08 +0100 4204228 http://www.medworm.com/index.php?rid=4204227&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050210001527%2Fabstract%3Frss%3Dyes (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4204227 Sat, 27 Nov 2010 05:30:08 +0100 4204227 http://www.medworm.com/index.php?rid=4204226&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS147305021000145X%2Fabstract%3Frss%3Dyes During the XIX Regional Congress of the International Society of Blood Transfusion in Cairo, Egypt (2009), two symposia were organized that focused on safety and indications for the use of plasma components. One symposium, entitled “Plasma Safety: Meet the Expert”, addressed the safety of plasma products and among the presenters were R. Knight (United Kingdom), U. Sachs (Germany), and S.G. Sandler (United States). The second symposium, entitled “The Blood Bank as Adviser in Plasma Transfusion Therapy”, addressed indications and presentations. Among the panel of invited presenters were P. Johansson (Denmark) and W. Mayr (Austria). Nearly 2years later, these five participants have been invited to summarize and update their presentations for readers of this Theme Section of Transfusio... Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4204226 Sat, 27 Nov 2010 05:30:08 +0100 4204226 http://www.medworm.com/index.php?rid=4204225&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050210001928%2Fabstract%3Frss%3Dyes Abstract: Anti-PP1Pk is a rare, biphasic antibody with the ability to cause immediate hemolytic transfusion reactions and early spontaneous abortions. The antibody is formed by individuals with the p phenotype. A blood donor with anti-PP1Pk and the p phenotype was identified through routine donor screening. A sister was found to also be p phenotype. At that time, the sister was 24weeks pregnant. Subsequently, the original blood donor became pregnant. Both individuals were followed throughout their pregnancies and delivered infants without complications from anti-PP1Pk antibodies. The literature regarding anti-PP1Pk, the p phenotype, and recurrent pregnancy loss in this setting is reviewed. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4204225 Sat, 27 Nov 2010 05:30:08 +0100 4204225 http://www.medworm.com/index.php?rid=4204224&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS147305021000193X%2Fabstract%3Frss%3Dyes Abstract: Being underweight is associated with a poorer outcome after haematopoietic stem cell transplantation (HSCT). We investigated whether nutritional status affects a patient’s ability to mobilise stem cells.Weights, heights, peripheral blood CD34 counts and total collected stem cells were collected on 305 patients.Those patients who were underweight had a lower median peripheral blood CD34 count than those who were not underweight (36.0 vs. 53.0×106/L (p=0.0047)). However, the proportion of patients achieving a collection containing the minimum number of CD34 cells required to define a successful stem cell collection was similar in those who were underweight and those who were not.Therefore being underweight may reduce a patient’s ability to mobilise peripheral blood stem cells ... Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4204224 Sat, 27 Nov 2010 05:30:08 +0100 4204224 http://www.medworm.com/index.php?rid=4204223&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050210001916%2Fabstract%3Frss%3Dyes Abstract: A 19-month-old boy presented RBC T-cryptantigen (TCA) activation with severe pneumonia complicated with abnormal coagulation. The boy received fresh frozen plasma before TCA activation was confirmed. He developed hemolysis and multiple organ failure. The hemolysis anemia was successfully treated with washed RBC transfusion. However, he had to use dialysis because of renal dysfunction. The case prompted an urgent call to screen RBC TCA-activation in selective pediatric patients. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4204223 Sat, 27 Nov 2010 05:30:08 +0100 4204223 http://www.medworm.com/index.php?rid=4204222&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050210001898%2Fabstract%3Frss%3Dyes Abstract: Pemphigus vulgaris (PV) and epidermolysis bullosa acquisita (EBA) sometimes resist treatments. In drug-resistant cases, adjuvant treatment with extracorporeal photochemotherapy (ECP) has been reported to induce remission. However, limited numbers of patients have been reported up to date. Eleven patients with drug-resistant autoimmune bullous diseases have been treated with ECP (8 patients with PV, 3 patients with EBA). The introduction of ECP to systemic therapies of the patients with PV resulted in complete response (CR) after a limited cycle (2–6 cycles) in all, except one patient. Prednisolone doses could be tapered in all patients. ECP resulted in CR in two patients while improvement was partial in one patient with EBA after 3–6 cycles. Our patients demonstrate the effic... Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4204222 Sat, 27 Nov 2010 05:30:07 +0100 4204222 http://www.medworm.com/index.php?rid=4204221&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050210001850%2Fabstract%3Frss%3Dyes Abstract: In thrombotic events and diseases such as cancer, HIV/AIDS, dysfibrinogenaemia, as well as acute incidents (e.g. burn wounds), ultrastructure of platelets and fibrin networks change. In the current study, we compare the ultrastructure of platelets and fibrin networks of apheresis platelets stored in citrated human plasma (CP) and in a first-generation platelet additive solution (PAS) (T-Sol), to that of fresh donor plasma (FP). Eighteen apheresis platelet donors donated platelets on Trima®-Accel™ V5.2 and V5.1 cell separators. Six collections were stored for five days in autologous citrated plasma (CP); six collections were stored in 40% citrated human plasma and 60% PAS solution (CP/PAS) controlled, for the duration of storage, at a constant temperature (22±2°C) with contin... Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4204221 Sat, 27 Nov 2010 05:30:07 +0100 4204221 http://www.medworm.com/index.php?rid=4204220&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050210001886%2Fabstract%3Frss%3Dyes Conclusion: Targeting inappropriate transfusions by vetting particularly for inappropriate transfusions not only re-directs blood away from those unlikely to benefit, but is also more effective at preserving the red blood cells than other measures during times of supply limitation. Contingency planning needs to accommodate the variable case-mix in hospitals, allocate resources for transfusion medicine specialists to review every transfusion request and may be better coordinated at a jurisdictional level. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4204220 Sat, 27 Nov 2010 05:30:07 +0100 4204220 http://www.medworm.com/index.php?rid=4204219&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050210001862%2Fabstract%3Frss%3Dyes Abstract: This was a prospective randomized controlled trial to evaluate the effects of immunoadsorption (IA) versus conventional PP (PP) as adjunctive therapy in the treatment of severe lupus nephritis (LN).Of 28 patients with biopsy-proven severe LN (ISN/RPS classes III or IV±V), 14 underwent 36 sessions of PP and the other 41 sessions of IA in addition to our center’s standard LN treatment protocol. Three patients in the PP group and 2 in the IA group experienced a transient, marked drop in platelets with the second session. Except for a higher pre treatment mean SLEDAI score in the PP group 17.4±2.0 vs. 13.5±4.8; p=0.009 and a serum creatinine of 163±7.9 vs. 81.7±10.2; p=0.33, there were no other baseline differences. Some differences did exist between the two therapies in the i... Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4204219 Sat, 27 Nov 2010 05:30:05 +0100 4204219 http://www.medworm.com/index.php?rid=4204218&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050210001874%2Fabstract%3Frss%3Dyes This report also reviews the literature to discuss established GVHD risk factors as well as provide recommendations for standardized reporting to better understand incidence rates and possible risk factors. This information would allow individual physicians and blood bank associations to make more informed decisions on the use of irradiated blood products. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4204218 Sat, 27 Nov 2010 05:30:05 +0100 4204218 http://www.medworm.com/index.php?rid=4204217&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050210001904%2Fabstract%3Frss%3Dyes Abstract: Seventeen cases of acute carbon-monoxide poisoning were treated with therapeutic red cell-exchange. Glasgow Coma Scale score was used to evaluate the level of consciousness. The mean carboxyhemoglobin level decreased from 0.286±0.1805 (28.6±18.05%) to 0.0613±0.0418 (6.13±4.18%) and Glasgow Coma Scale score increased from 10±3 to 13.76±1.89. While 11 patients scored 15 at the end of the treatment, four scored 15 in an hour after the treatment. None of the patients died. Two victims (11.7%) experienced ischemic encephalopathy. Therapeutic red cell-exchange therapy can be an effective treatment in reducing mortality and morbidity in carbon-monoxide poisoning. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4204217 Sat, 27 Nov 2010 05:30:05 +0100 4204217 http://www.medworm.com/index.php?rid=4204216&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050210001849%2Fabstract%3Frss%3Dyes In conclusion a single dose of Pegfilgrastim could be a valid alternative to unconjugated G-CSF to mobilize PBSC in lymphoma patients. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4204216 Sat, 27 Nov 2010 05:30:05 +0100 4204216 http://www.medworm.com/index.php?rid=4204215&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050210001643%2Fabstract%3Frss%3Dyes In this study we have determined that the number of the CD34 (+) cells in the grafts that were infused to 48 patients who underwent autologous and allogeneic hematopoietic cell transplantation and evaluated the number of colony forming units in vitro. Our aim was to determine whether there is a relation between these cell counts and post transplantation engraftment kinetics. A negative correlation was detected (p (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4204215 Sat, 27 Nov 2010 05:30:05 +0100 4204215 http://www.medworm.com/index.php?rid=4204214&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050210001588%2Fabstract%3Frss%3Dyes Conclusion: This study indicates the importance of proper specimen labeling and implemented cost-effective, non-compromising policy of rejecting each mislabelled specimen and realises the importance of ongoing quality monitoring to improve laboratory performance. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4204214 Sat, 27 Nov 2010 05:30:04 +0100 4204214 http://www.medworm.com/index.php?rid=4204213&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050210001606%2Fabstract%3Frss%3Dyes Conclusion: TPE through the plasma collection machine is a well tolerated, economic and effective treatment. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4204213 Sat, 27 Nov 2010 05:30:04 +0100 4204213 http://www.medworm.com/index.php?rid=4204212&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS147305021000162X%2Fabstract%3Frss%3Dyes Conclusions: Rituximab appears to be a safe, effective therapy and has a high response rate for the treatment of acute refractory or relapsing idiopathic TTP in adult patients. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4204212 Sat, 27 Nov 2010 05:30:04 +0100 4204212 http://www.medworm.com/index.php?rid=4204211&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050210001618%2Fabstract%3Frss%3Dyes Abstract: The current study evaluated the impact of blood donation coping brochures, adapted to address known predictors of non-donation, among Australians who had not previously donated blood. Participants read a donation coping brochure that either (1) incorporated a first-time donor narrative or (2) omitted the narrative, (3) a standard donor recruitment brochure, or (4) a control brochure focusing on exercise. Whilst both of the coping brochures resulted in significant changes in intention and a number of its predictors, the version with a donor narrative resulted in significantly greater improvements in self efficacy, intention, and fewer anticipated vasovagal reactions than the standard donor recruitment brochure. The findings indicate that specifically-designed brochures can enhance... Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4204211 Sat, 27 Nov 2010 05:30:03 +0100 4204211 http://www.medworm.com/index.php?rid=4204210&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050210001539%2Fabstract%3Frss%3Dyes We report here on two cases with severe (triglyceride level >1000mg/dL) hypertriglyceridemia-induced acute recurrent pancreatitis. Both patients had uncontrolled hypertriglyceridemia and suffered from acute pancreatitis. No cause of secondary hypertriglyceridemia was detected. While stage E pancreatitis (Ranson’s score: 2) was diagnosed in the first case, stage D pancreatitis with a null Ranson’s score was detected in the second case. Both patients were treated with classical treatment with fluid replacement, analgesic, antibiotics and discontinuation of oral intake. Therapeutic plasma exchange (TPE) with fresh frozen plasma was performed consecutively and with two procedures on the 2nd and 3rd day in the first case. After TPE, while the triglyceride levels decreased from 4408 to 302mg... Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4204210 Sat, 27 Nov 2010 05:29:59 +0100 4204210 http://www.medworm.com/index.php?rid=4204209&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050210001540%2Fabstract%3Frss%3Dyes Conclusion: Severe HDFN with rare antibodies can be managed successfully using maternal blood. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4204209 Sat, 27 Nov 2010 05:29:59 +0100 4204209 http://www.medworm.com/index.php?rid=4204208&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS147305021000159X%2Fabstract%3Frss%3Dyes Conclusions: ARCE can alter the CEC number, suggesting the possibility of suppression of endothelial activation. This may highlight the efficacy of ARCE for prevention or management of sickle cell vaso-occlusive crisis. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4204208 Sat, 27 Nov 2010 05:29:59 +0100 4204208 http://www.medworm.com/index.php?rid=4204207&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050210001576%2Fabstract%3Frss%3Dyes Abstract: Aim: Serologic tests having high sensitivity and specificity are used in order to prevent contamination with infectious agents from blood and blood products for transfusion safety. The present serologic tests have problems such as low sensitivity and weak detection capacity of infectious agents in the “window period”. We aimed to test the use of NAT (Nucleic Acid Amplification Test) in routine blood screening in the Blood Bank.Method: We used the Procleix Ultrio (Chiron Ltd., USA) test kit based TMA (Transcription Mediated Amplification) for the NAT study of serum samples from 18,200 donors who came to the Turkish Red Crescent between February 2007 and September 2008. The NAT positive samples were studied twice. The discrimination of HIV, HCV and HBV NAT positive samples was ... Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4204207 Sat, 27 Nov 2010 05:29:59 +0100 4204207 http://www.medworm.com/index.php?rid=4204206&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050210001564%2Fabstract%3Frss%3Dyes Conclusion: As a result, even we have detected one HBV transmission in every 2142 blood transfusion by HBsAg screening tests; we suggest that it is not necessary to add additional tests to detect isolated Anti-HBc for routine purposes in Blood Banking. The reasons are higher negativity rates (99%) of isolated Anti-HBc serum samples and the rejection of blood donors with Anti-HBc positivity. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4204206 Sat, 27 Nov 2010 05:29:58 +0100 4204206 http://www.medworm.com/index.php?rid=4204205&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050210001552%2Fabstract%3Frss%3Dyes Abstract: Antigen D incompatibility between mother and fetus is the most frequent cause of red-cell alloimmunization. However there are surface antigens capable of producing hemolytic disease other than antigen D. Populational antigen frequencies may be country specific. The aim of this retrospective study was to evaluate the incidence of red-cell alloimmunization due to non-anti-D antibodies during pregnancy. We evaluated the indirect antiglobulin test results of 535 pregnant women performed between March 2003 and 2009. The incidence of non-anti-D antibodies was found 1.21%, similar with reported in literature, but the spectrum of non-anti-D antibodies was different from other countries. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4204205 Sat, 27 Nov 2010 05:29:58 +0100 4204205 http://www.medworm.com/index.php?rid=4204204&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050210001631%2Fabstract%3Frss%3Dyes This study evaluates the cost-effectiveness of OctaplasLG® (pharmaceutically licensed plasma for transfusion) versus fresh frozen plasma (FFP) in critically ill patients in the UK using a decision-analytic approach. Transfusion with OctaplasLG® resulted in 0.03 quality adjusted life years (QALYs) and 0.03 life years saved compared with FFP. The discounted cost per life year was £949 ($1504), and the discounted cost per QALY saved was £1030 ($1632) with OctaplasLG® in the UK. Based on a higher price of £70 ($111) for OctaplasLG® versus £28.42 ($45.04) for FFP, OctaplasLG® is considered to be cost-effective at a threshold of £30,000 ($47,548) per QALY. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4204204 Sat, 27 Nov 2010 05:29:58 +0100 4204204 http://www.medworm.com/index.php?rid=4204203&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050210001965%2Fabstract%3Frss%3Dyes I would like to recognize three members of our Editorial Board who have stepped down during the past year. With gratitude for their many years of valuable work and dedication, I sincerely thank Dr. John Freedman, Dr. Ed Taft, and Dr. Leo McCarthy, and wish them the very best in the future. Also, at this time we are delighted to welcome two new members to the Editorial Board: Dr. Hans Vrielink from the Netherlands, and Dr. Rainer Moog from Germany. I look forward to working with these two people in the years ahead. (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4204203 Sat, 27 Nov 2010 05:29:58 +0100 4204203 http://www.medworm.com/index.php?rid=4204202&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050210001990%2Fabstract%3Frss%3Dyes (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4204202 Sat, 27 Nov 2010 05:29:58 +0100 4204202 http://www.medworm.com/index.php?rid=4101984&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050210001795%2Fabstract%3Frss%3Dyes (Source: Transfusion and Apheresis Science) Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4101984 Thu, 30 Sep 2010 23:00:00 +0100 4101984 http://www.medworm.com/index.php?rid=4101983&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050210001199%2Fabstract%3Frss%3Dyes We read with interest the comprehensive Canadian review of the off-label use of recombinant activated factor VII (rFVIIa) in cardiac surgery by Karkouti and colleagues published recently in Circulation . This observational study showed the pattern of use of rFVIIa in Canadian cardiac centers and highlighted the difference between the centers of high and low treatment rates. In that respect the authors fulfilled one of the objectives they set out to achieve. However, when it comes to the second and probably the main objective of the study as was stated in the background section of the abstract, the assessment of predictors of effectiveness and risk, we do not believe the authors were as successful. The only bivariate analysis shown in the manuscript was the one that was run between survivor... Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4101983 Thu, 30 Sep 2010 23:00:00 +0100 4101983 http://www.medworm.com/index.php?rid=4101982&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050210001205%2Fabstract%3Frss%3Dyes Abstract: We evaluated the efficiency, safety and risks of three techniques which were used for autologous PBPC collections: (a) large-volume leukapheresis (LVL), (b) standard collections, and (c) a new modified technique which was named as “Mixed” collections.In spite of the fact that the standard and LVL collection techniques are used routinely, there may occur special conditions in which the procedures cannot be recommended. Some patients may suffer from serious clinical complications and they cannot tolerate either standard procedures with administration of higher doses of ACD-A, or the high extent of procedure in the course of LVL. We tried to find the safe and efficient collection technique which could help this group of patients to overcome their problems. The “Mixed” collec... Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4101982 Thu, 30 Sep 2010 23:00:00 +0100 4101982 http://www.medworm.com/index.php?rid=4101981&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050210001217%2Fabstract%3Frss%3Dyes Abstract: As the demand for kidney transplantation is constantly growing methods to expand the donor pool have become increasingly important. ABO-incompatibility has hitherto been regarded as an absolute contraindication to living donor donation. However, as ABO-incompatibility has accounted for the majority of living donor exclusions, efforts have been made to overcome this immunologic barrier. Successful desensitization protocols thus far, have combined plasmapheresis for antibody removal with splenectomy to reduce the antibody producing B-cell pool, in addition to quadruple immunosuppression. Although good graft function has been achieved, the high risks involved have been deterrent.We have developed a protocol for ABO-incompatible kidney transplantation based on antigen-specific immuno... Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4101981 Thu, 30 Sep 2010 23:00:00 +0100 4101981 http://www.medworm.com/index.php?rid=4101980&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS147305021000128X%2Fabstract%3Frss%3Dyes Abstract: Therapeutic apheresis, a novel approach for immunodisorders, has been used in the last decade for the treatment of ulcerative colitis with promising result, and represents an alternative to conventional pharmacological therapy. Selective apheresis is aimed at reducing the number of circulating lymphocytes, interfering with recruitment and activation of mucosal granulocytes and macrophages, reducing cytokine and chemokine production which are thought to contribute to induction and perpetuation of inflammation. The article briefly reports indications, treatment schedule and clinical results of leukocytapheresis in ulcerative colitis. Available data for the two selective adsorption devices so far approved for clinical use (granulocyte-monocyte apheresis- Adacolumn- and leukocytapher... Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4101980 Thu, 30 Sep 2010 23:00:00 +0100 4101980 http://www.medworm.com/index.php?rid=4101979&cid=s_36125_19_f&fid=36125&url=http%3A%2F%2Fwww.trasci.com%2Farticle%2FPIIS1473050210001291%2Fabstract%3Frss%3Dyes Abstract: Apheresis technology for pediatric patients and donors is still cumbersome, it is rare, mostly done in departments specialized for apheresis in adult patients, and therefore the staff is more or less anxious about dealing with especially little pediatric patients or donors. Our center is specialized in pediatrics and has a department for apheresis. We offered training courses for interested centers, which want to use the AMICUS™ system for leukapheresis in small children. In a 1–2day course the principles of leukapheresis in very small children were trained. To investigate the reproducibility of this training courses we invited the centers to share their data with us. As a standard we used a formula (C=[(AD):B×0.5]:1000) for predicting the CD34+ cell yield (C) by calculating... Transfusion and Apheresis Science journals http://www.medworm.com/rss/comments.php?id=4101979 Thu, 30 Sep 2010 23:00:00 +0100 4101979