MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Vox Sanguinis' source. Thu, 18 Mar 2010 14:32:02 +0100 http://www.medworm.com/index.php?rid=3375960&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2010.01322.x (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=3375960 Thu, 18 Mar 2010 00:00:00 +0100 3375960 http://www.medworm.com/index.php?rid=3364642&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2010.01307.x Conclusion In this study, restrictive ET criteria in neonates with Rh hemolytic disease lead to a reduction of the rate of ET but an increase in the number of top-up transfusions for neonatal anemia. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=3364642 Mon, 15 Mar 2010 00:00:00 +0100 3364642 http://www.medworm.com/index.php?rid=3351969&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2010.01319.x (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=3351969 Thu, 11 Mar 2010 00:00:00 +0100 3351969 http://www.medworm.com/index.php?rid=3351972&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2010.01329.x Conclusion Understanding current practice will help in the design of future studies for CTP storage and transportation. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=3351972 Wed, 10 Mar 2010 00:00:00 +0100 3351972 http://www.medworm.com/index.php?rid=3351971&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2010.1315.x (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=3351971 Wed, 10 Mar 2010 00:00:00 +0100 3351971 http://www.medworm.com/index.php?rid=3351970&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2010.01321.x Conclusion Post-transfusion increment in circulating haemoglobin can be predicted from the haemoglobin content of transfused cells, but knowledge of the patient's blood volume improves the accuracy of prediction. It may be feasible to select the high haemoglobin content RBC for patients with largest blood volume and vice versa. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=3351970 Wed, 10 Mar 2010 00:00:00 +0100 3351970 http://www.medworm.com/index.php?rid=3317202&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2010.01320.x Conclusions The psychological and behavioural impacts of the earthquake on blood donors extended far from the epicentre. After a disaster, it is important to emphasize that donors must be truthful on the donor questionnaire as some donors appear willing to be less than honest when they perceive an increased need for blood products. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=3317202 Mon, 01 Mar 2010 00:00:00 +0100 3317202 http://www.medworm.com/index.php?rid=3308655&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2010.01317.x Conclusion 2008 Serious Hazards of Transfusion data showed that 29/39 (74%) of laboratory errors resulting in 'wrong blood' occurred out of hours whilst our audit shows that only 25% of crossmatch requests are made in that time period, suggesting that crossmatching performed outside core hours carries increased risks. The reason for increased risk of error needs further research, but 25 laboratories had only one member of staff working out of hours, often combining blood transfusion, haematology and coagulation work. A total of 25% of out of hours requests were not clinically urgent. Hospitals should develop policies to define indications for out of hours transfusion testing, empower laboratory staff to challenge inappropriate requests and ensure that staffing and expertise is appropriate ... Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=3308655 Fri, 26 Feb 2010 00:00:00 +0100 3308655 http://www.medworm.com/index.php?rid=3308656&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2010.01314.x Conclusion 07/164 was established as the 2nd IS for hepatitis B immunoglobulin with an assigned potency of 100 IU/ampoule by the WHO Expert Committee on Biological Standardisation. The United States Food and Drug Administration has adopted the same standard as the new Reference for Hepatitis B Immunoglobulin, Lot 3. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=3308656 Thu, 25 Feb 2010 00:00:00 +0100 3308656 http://www.medworm.com/index.php?rid=3299799&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01302.x Conclusion The elaborated protocol allows temperatures to be maintained between 2 and 6°C as required by European guidelines for at least 36 h each and between 1 and 10°C as required by German guidelines for at least 48 or 64 h at ambient temperatures between [minus]10 and 40°C. Preliminary results indicate that care must be taken concerning additional factors such as air pressure variation or vibration. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=3299799 Wed, 24 Feb 2010 00:00:00 +0100 3299799 http://www.medworm.com/index.php?rid=3299798&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2010.01312.x Conclusion Transfusion data from a limited sample of hospitals can be used to estimate national distributions of blood recipient characteristics. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=3299798 Wed, 24 Feb 2010 00:00:00 +0100 3299798 http://www.medworm.com/index.php?rid=3296060&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2010.01313.x Conclusions The data reported in this study suggest a link between the specific whole blood donor and the haemolysis levels observed in red-blood-cell units stored refrigerated for 42 days. Additional research to identify possible donor characteristics associated with haemolysis during storage is warranted. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=3296060 Tue, 23 Feb 2010 00:00:00 +0100 3296060 http://www.medworm.com/index.php?rid=3260653&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2010.01310.x (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=3260653 Thu, 11 Feb 2010 00:00:00 +0100 3260653 http://www.medworm.com/index.php?rid=3260652&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2010.01311.x Conclusion Neutrophils activated with sera containing HLA Class I alloantibody caused the preferential degranulation of azurophilic granules and secretory vesicles. This process was at least in part mediated by p38 MAP kinase-involved signal transduction. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=3260652 Thu, 11 Feb 2010 00:00:00 +0100 3260652 http://www.medworm.com/index.php?rid=3233246&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2010.01309.x (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=3233246 Wed, 03 Feb 2010 00:00:00 +0100 3233246 http://www.medworm.com/index.php?rid=3233249&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01258.x (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=3233249 Tue, 02 Feb 2010 00:00:00 +0100 3233249 http://www.medworm.com/index.php?rid=3233248&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01280.x (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=3233248 Tue, 02 Feb 2010 00:00:00 +0100 3233248 http://www.medworm.com/index.php?rid=3233247&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2010.01308.x (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=3233247 Tue, 02 Feb 2010 00:00:00 +0100 3233247 http://www.medworm.com/index.php?rid=3218365&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01301.x (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=3218365 Fri, 29 Jan 2010 00:00:00 +0100 3218365 http://www.medworm.com/index.php?rid=3169140&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01306.x Conclusion Potentially infectious donors can be identified by measuring CMV DNA, IgM antibodies or avidity of IgG antibodies. Alternatively, blood products donated during the first year after seroconversion should not be used for immunocompromised patients. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=3169140 Thu, 14 Jan 2010 00:00:00 +0100 3169140 http://www.medworm.com/index.php?rid=3165305&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01299.x Previous work has shown that optimal ex vivo expansion and differentiation of CD34+ progenitor cells into neutrophils is by addition of Flt3-L, SCF and G-CSF. Here we report that a variety of genes involved in the WNT pathway are transcriptionally active in both undifferentiated and differentiated umbilical cord blood CD34+ cells, however statistically significant changes in gene expression are not always consistent across UCB samples. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=3165305 Tue, 12 Jan 2010 00:00:00 +0100 3165305 http://www.medworm.com/index.php?rid=3161178&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01305.x Conclusion The lot release system has proved to be effective in objectively assessing assay performance to ensure that there is no significant lot-to-lot variation such that the performance of the assay may fall below that originally determined at evaluation. The few assays that have failed lot release did have proven performance issues that were subsequently accepted by the manufacturers.Contents Summary Description of the Lot Release Testing system for serology infectious disease screening assays in use within NHSBT with a critical analysis and review of the data generated in the 7 years that the system has been in use. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=3161178 Tue, 12 Jan 2010 00:00:00 +0100 3161178 http://www.medworm.com/index.php?rid=3161180&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01298.x (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=3161180 Mon, 11 Jan 2010 00:00:00 +0100 3161180 http://www.medworm.com/index.php?rid=3161179&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01304.x Conclusions The present case illustrates the importance of introducing highly sensitive HBV NAT screening strategy to prevent possible HBV transfusion-transmitted infections from donors with low viral load. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=3161179 Mon, 11 Jan 2010 00:00:00 +0100 3161179 http://www.medworm.com/index.php?rid=3150709&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01292.x (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=3150709 Fri, 08 Jan 2010 00:00:00 +0100 3150709 http://www.medworm.com/index.php?rid=3138134&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01295.x There is an ongoing debate whether platelet concentrates (PCs) prepared from either whole-blood donations or by plateletpheresis are superior. Usage of these two product types varies greatly between countries and individual institutions. Some use mainly apheresis PCs; others prefer pooled PCs which are produced from whole-blood donations. This review summarizes the existing information on these product types. In the first part data on quality, efficacy and safety are reviewed. It is important to note that the issue cannot be answered just by comparing 'the' apheresis platelet concentrate versus 'the' pooled platelet concentrate. Other factors which determine the quality of a product, e.g. residual leukocyte count, plasma content, additive solution or storage period may be even more importa... Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=3138134 Mon, 04 Jan 2010 00:00:00 +0100 3138134 http://www.medworm.com/index.php?rid=3138133&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01296.x Conclusions The knowledge of staff at the extreme ends of the clinical interface in their counterparts' working domain is far from adequate. However, they have well formed opinions on strategies to improve this interface. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=3138133 Mon, 04 Jan 2010 00:00:00 +0100 3138133 http://www.medworm.com/index.php?rid=3138132&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01297.x Conclusion The effects of education level and cultural aspects should be taken into account as influencers on donation behaviour. The concept of power distance, in particular, presents a challenge to blood donor managers in cross-cultural and multi-cultural donor management contexts. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=3138132 Mon, 04 Jan 2010 00:00:00 +0100 3138132 http://www.medworm.com/index.php?rid=3138131&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01300.x Conclusion RBCs, collected from bone marrow harvests, can be used for autologous blood support to minimize allogeneic blood transfusions in donors and patients after large volume BM donation. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=3138131 Mon, 04 Jan 2010 00:00:00 +0100 3138131 http://www.medworm.com/index.php?rid=3073120&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01290.x Conclusions Risk-adjusted assessments of blood product use based on administrative data allow hospital-wide evaluation of transfusion use. Comparing blood use between different hospitals contributes toward establishing appropriate transfusion practices. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=3073120 Thu, 10 Dec 2009 00:00:00 +0100 3073120 http://www.medworm.com/index.php?rid=3073119&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01274.x Conclusion A national emergency, September 11, 2001, inspired people to donate blood for the first time. However, the proportion of return donations amongst them was not increased. Females and males in certain age groups were more likely to become repeat donors due to the residual effect of September 11, 2001. Additional efforts are needed to retain eligible FTD in donor pools. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=3073119 Thu, 10 Dec 2009 00:00:00 +0100 3073119 http://www.medworm.com/index.php?rid=3064743&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01291.x Conclusion The detailed frequencies distribution of ABO alleles was studied in the Chinese Han population. We identified 14 alleles, including 3 novel alleles. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=3064743 Tue, 08 Dec 2009 00:00:00 +0100 3064743 http://www.medworm.com/index.php?rid=3064742&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01288.x Conclusions On the basis of the data presented in this collaborative study, Sample 2 (code number 99/802) was established as the 2nd International Standard for parvovirus B19 DNA for NAT-based assays with a potency of 106 IU/ml (500 000 IU/vial). (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=3064742 Tue, 08 Dec 2009 00:00:00 +0100 3064742 http://www.medworm.com/index.php?rid=3064744&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.1293.x (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=3064744 Mon, 07 Dec 2009 00:00:00 +0100 3064744 http://www.medworm.com/index.php?rid=3041471&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01289.x Introduction Mirasol Pathogen Reduction Technology® (PRT) treatment uses riboflavin and UV light to inactivate pathogens in blood components. Neutrophil [polymorphonuclear cells (PMN)] priming activity accumulates during routine storage of cellular blood components, and this activity has been implicated in transfusion-related acute lung injury (TRALI). We hypothesize that PRT-treatment of blood components affects the priming activity generated during storage of packed RBCs (PRBCs) or platelet concentrates (PCs), which can elicit ALI in vivo.Methods Plasma, PRBCs and PCs were isolated from healthy donor's whole blood or by apheresis. Half of a collected unit was treated with PRT treatment and the remainder was left as an unmodified control. Supernatant was collected during storage of PCs a... Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=3041471 Tue, 01 Dec 2009 00:00:00 +0100 3041471 http://www.medworm.com/index.php?rid=3028020&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01286.x There exists considerable risk for transfusion transmission of arboviruses due to short periods of asymptomatic viraemia in populations with variable and sometimes extremely high incidence of arboviral infections. Aside from West Nile virus, few arbovirus transfusion transmissions have been proven, mostly due to difficulties in ruling out vector-borne transmission in recipients with arbovirus disease. Nevertheless, arbovirus transfusion risk models and assessments of viraemia prevalence in blood donations indicate substantial transfusion transmission of dengue and Chikungunya viruses in epidemic areas. Many other arboviruses, several of which are importation risks in the Americas, Europe and Asia, also cause large outbreaks and threaten transfusion safety. Prevention largely depends on exc... Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=3028020 Thu, 26 Nov 2009 00:00:00 +0100 3028020 http://www.medworm.com/index.php?rid=3028023&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01281.x The objective of our study was to further optimize donor selection by finding donor characteristics which predict the total nucleated cell concentration in unrelated bone marrow products.Material and Methods Data were collected retrospectively from the pre-donation medical records. The outcome variable was concentration of total nucleated cells in the final products. We investigated several candidate predictors, including demographic variables and peripheral blood counts. A backward selection procedure was performed, using multivariable multilevel analysis.Results A total of 471 donations were included. Significant predictors were increase of age (ratio per 5 years 0·971), cytomegalovirus (ratio 0·947 if positive), smoking (ratio 1·079 if yes), higher haemoglobin (ratio 1·052 per mmol/... Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=3028023 Wed, 25 Nov 2009 00:00:00 +0100 3028023 http://www.medworm.com/index.php?rid=3028022&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01282.x Chronic hepatitis B affects approximately 400 million people in the world with a substantial disease burden like liver cirrhosis and hepatocellular carcinoma (HCC). Treatment for chronic hepatitis B has improved dramatically in the last decade, resulting in more patients achieving a state of inactive disease. Currently two treatment strategies are available; treatment with peginterferon (peg-IFN) or nucleos(t)ide analogues with the aim to suppress hepatitis B virus (HBV) DNA to subsequently avoid the development of cirrhosis and HCC. Unfortunately, treatment with peg-IFN can be suboptimal with important adverse effects and nucleos(t)ide analogues provoke resistance. At present, no new promising compounds attacking the HBV life cycle are in development. However, for prediction of sustained ... Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=3028022 Wed, 25 Nov 2009 00:00:00 +0100 3028022 http://www.medworm.com/index.php?rid=3028021&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01285.x Conclusions Capillary haemoglobin levels of 12·0[ndash]12·5 g/dl in healthy females or 13·0[ndash]13·5 g/dl in healthy males are substantively equivalent to venous haemoglobin levels of [ge] 12·5 and [ge] 13·5 g/dl for women and men respectively. This finding has permitted an additional 32 990 blood units to be collected over the period of the study, a gain of 9·4%. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=3028021 Wed, 25 Nov 2009 00:00:00 +0100 3028021 http://www.medworm.com/index.php?rid=3020488&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01277.x Conclusion The low prevalence Rh antigen, Bea, is associated with a single nucleotide change in exon 5 of RHCE*ce; that of 662C>G and this change is predicted to alter proline at amino acid position 221 of Rhce to arginine. The fundamental differences in the properties of these two amino acids may impose a steric and/or charge-related effect on the protein, and thereby provide an explanation for the weakened expression of c, e and f (ce) antigens in the Bea phenotype. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=3020488 Tue, 24 Nov 2009 00:00:00 +0100 3020488 http://www.medworm.com/index.php?rid=3005936&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01284.x Conclusion Overall, the NHSBT screening programme for infectious agents in deceased tissue donors is very effective with a relatively low overall loss of donors because of non-specific reactivity. However, unnecessary loss of tissue products is not acceptable, and although this programme compares favourably with the outcomes of other such programmes, the confirmatory results obtained demonstrate both the need and the potential for improving the outcomes. This is particularly important as one donor may donate more than one product, and can be achieved very easily with a change to the screening algorithm followed, using the confirmatory data obtained to support and validate this change.Contents Summary Critical analysis of the NHSBT screening programme for infectious agents in deceased tissu... Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=3005936 Thu, 19 Nov 2009 00:00:00 +0100 3005936 http://www.medworm.com/index.php?rid=3005937&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01283.x Conclusion PLT concentrates in plasma, SSP+ and Composol scored better using an arbitrary rating system as PLTs stored in T-Sol or InterSol; PR further impaired rating parameters. The applicability of these differences in rating for clinical effects needs a clinical study. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=3005937 Wed, 18 Nov 2009 00:00:00 +0100 3005937 http://www.medworm.com/index.php?rid=2956466&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01272.x Conclusion Diagnostic efficacy of the evaluated HBsAg test kits differed substantially. Laboratories should therefore be aware of the analytical sensitivity for HBsAg and check for the relevant HBV variants circulating in the relevant population. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2956466 Wed, 04 Nov 2009 00:00:00 +0100 2956466 http://www.medworm.com/index.php?rid=2949242&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01252.x (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2949242 Mon, 02 Nov 2009 00:00:00 +0100 2949242 http://www.medworm.com/index.php?rid=2949241&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01271.x Conclusion It was shown that suitable complement batches have to be identified in a screening procedure. Furthermore, it could be demonstrated that IgG polymers formed in the neutral pH range during heat treatment were potential ACA inducing compounds. Manufacturing the IVIG preparations under acidic conditions may help to avoid the formation of those ACA active polymers. Thus, intensive analysis of ACA during process development and validation is recommended. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2949241 Mon, 02 Nov 2009 00:00:00 +0100 2949241 http://www.medworm.com/index.php?rid=2949240&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01273.x Conclusions The experience of vasovagal symptoms may not deter people who are generally confident in their ability to tolerate blood donation. However, among people who are ambivalent about needles, symptoms may 'confirm' pre-existing doubts about their suitability for blood donation and lead to drop-out. Targeted interventions that give the uncertain volunteer a sense of confidence that they might be able to realize their goal and become a regular blood donor may be useful. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2949240 Mon, 02 Nov 2009 00:00:00 +0100 2949240 http://www.medworm.com/index.php?rid=2949239&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01265.x Conclusion Although there is some evidence to support the increase use of plasma and platelets in massive transfusion, the true efficacy of such practice has not yet been proven by prospective randomized controlled trials. The available retrospective studies raise many important questions that need to be addressed in future clinical trials. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2949239 Mon, 02 Nov 2009 00:00:00 +0100 2949239 http://www.medworm.com/index.php?rid=2949238&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01278.x Conclusion When an AHG XM becomes reactive after negative ABS result, this is caused with very few exceptions by clinically irrelevant reactivities. This especially accounts for reactive AHG XM using the MCT. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2949238 Mon, 02 Nov 2009 00:00:00 +0100 2949238 http://www.medworm.com/index.php?rid=2941173&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01276.x Conclusions These findings raise the important question of whether lower doses of rFVIIa may be as effective as higher doses in the treatment of severe bleeding in cardiac surgery patients. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2941173 Fri, 30 Oct 2009 00:00:00 +0100 2941173 http://www.medworm.com/index.php?rid=2941175&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01263.x (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2941175 Thu, 29 Oct 2009 00:00:00 +0100 2941175 http://www.medworm.com/index.php?rid=2941174&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01275.x Conclusions No identified study indicated that raised baseline blood pressure level, treated hypertension or diabetes was predictive of increased adverse reactions in blood donors but the level of overall evidence was limited. This is the first attempt to systematically review a donor area as part of an approach to change longstanding practice recommendations, and may have implications for other recommendations for changes in donor acceptance criteria. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2941174 Thu, 29 Oct 2009 00:00:00 +0100 2941174 http://www.medworm.com/index.php?rid=2932569&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01270.x Conclusion Iron supplementation had a significant positive impact on the restoration of iron status one week after donation. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2932569 Wed, 28 Oct 2009 00:00:00 +0100 2932569 http://www.medworm.com/index.php?rid=2928856&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01268.x Conclusions Donor and maternal platelet concentrates are effective sources for the treatment of FAIT. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2928856 Tue, 27 Oct 2009 00:00:00 +0100 2928856 http://www.medworm.com/index.php?rid=2888183&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01269.x The ABO system is the most important blood group system in transfusion and transplantation medicine. Over the last decade ABO genotyping was introduced to complement serological analysis but because of the enormous diversity at the ABO locus, DNA-based typing is highly sophisticated. In some genotype combinations and especially when dealing with hybrid genes, cis/trans linkage analysis is necessary. Therefore, we developed a simple and reliable approach to isolate ABO haplotypes. The described method physically separates diploid genomic DNA using probe-dependent allele hybridization followed by magnetic bead separation. After this haplotype-specific extraction (HSE), sequencing based typing (SBT) was performed to analyze coding and non-coding respectively regulatory regions of ABO. (Source... Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2888183 Tue, 13 Oct 2009 23:00:00 +0100 2888183 http://www.medworm.com/index.php?rid=2881868&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01264.x The increase in platelets in patients with immune thrombocytopenia (ITP) by intravenous administration of human immunoglobulin concentrates (IVIG) reflects a therapeutic immunomodulatory intervention targeted at the disturbed immune response in many inflammatory and autoimmune disorders. These immunoglobulin concentrates contain large numbers of antibodies as well as trace levels of various other immunologically active molecules. Clinical and laboratory studies have documented various mechanisms of action of IVIG. The complex network of immunological reactions resulting from the infusion of IVIG includes changes in several cytokines, interactions with dendritic cells, T- and B- lymphocyte effects, macrophage effects, mediated by distinct Fc-gamma receptors. In addition, effects on compleme... Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2881868 Sun, 11 Oct 2009 23:00:00 +0100 2881868 http://www.medworm.com/index.php?rid=2867179&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01267.x Conclusion Most of the gender differences in donation patterns could be ascribed to absence because of pregnancy and lactation. Practical problems and discomfort during donation were important reasons why women reported to have stopped donation. Current deferral criteria pose problems for the recruitment and retention especially of young women. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2867179 Tue, 06 Oct 2009 23:00:00 +0100 2867179 http://www.medworm.com/index.php?rid=2826120&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01255.x Conclusion Our results suggest that PLTs stored in PAS with addition of magnesium, potassium and glucose (PSM2 and PSM3) and 20% plasma carry-over maintained metabolic and cellular characteristics, equivalent to PLTs stored in 100% plasma during 9 days of storage. Our results also suggest that presence of potassium in addition to magnesium or alternatively the concentration of phosphate as well as the supply of additional glucose to normal plasma levels improve in vitro data of PLTs stored in PAS. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2826120 Wed, 23 Sep 2009 23:00:00 +0100 2826120 http://www.medworm.com/index.php?rid=2808779&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01256.x Conclusion Data on Micros 60 demonstrated that capillary predonation counts may represent a feasible and effective approach to realize an accurate enrolment process of blood and Plt donors. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2808779 Fri, 18 Sep 2009 23:00:00 +0100 2808779 http://www.medworm.com/index.php?rid=2808780&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01250.x Conclusions Design of the CUE form and characteristics of the CUE process may considerably influence the CUE rates. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2808780 Thu, 17 Sep 2009 23:00:00 +0100 2808780 http://www.medworm.com/index.php?rid=2791660&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01236.x Conclusion The data do not provide any indication of a safety benefit from CUE, but CUE use results in a small but constant loss of apparently safe donations. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2791660 Sun, 13 Sep 2009 23:00:00 +0100 2791660 http://www.medworm.com/index.php?rid=2791659&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01242.x Conclusion This study failed to find any association between the incidence of wound infection after knee arthroplasty and allogeneic transfusion. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2791659 Sun, 13 Sep 2009 23:00:00 +0100 2791659 http://www.medworm.com/index.php?rid=2791658&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01244.x (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2791658 Sun, 13 Sep 2009 23:00:00 +0100 2791658 http://www.medworm.com/index.php?rid=2776277&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01251.x Conclusion The study findings support the efficacy and safety of a targeted screening strategy combining a sensitive antibody screening test with a 4-month cellular component restriction period for donors with a declared malarial risk. The TTM risk in Australia remains low and did not measurably change after implementing the testing strategy. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2776277 Tue, 08 Sep 2009 23:00:00 +0100 2776277 http://www.medworm.com/index.php?rid=2776278&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01243.x Conclusion The three red cell antigens encoded by RHAG form the RHAG blood group system: Duclos is RHAG1 (030001); Ola is RHAG2 (030002); and DSLK is provisionally RHAG3 (030003). (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2776278 Mon, 07 Sep 2009 23:00:00 +0100 2776278 http://www.medworm.com/index.php?rid=2764016&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01248.x (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2764016 Thu, 03 Sep 2009 23:00:00 +0100 2764016 http://www.medworm.com/index.php?rid=2764018&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01246.x (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2764018 Wed, 02 Sep 2009 23:00:00 +0100 2764018 http://www.medworm.com/index.php?rid=2764017&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01247.x (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2764017 Wed, 02 Sep 2009 23:00:00 +0100 2764017 http://www.medworm.com/index.php?rid=2746652&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01238.x Conclusion Riboflavin and UV light-treated plasma demonstrates reductions in several plasma coagulation factors following treatment. This reduction in activity levels is noted immediately after treatment and remains relatively constant during 2 years of storage at [minus]30°C. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2746652 Sun, 30 Aug 2009 23:00:00 +0100 2746652 http://www.medworm.com/index.php?rid=2746654&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01249.x Conclusions Harboe and Drabkin's methods are suitable for measuring total haemoglobin and supernatant haemoglobin in RCC. The analyser gave higher haematocrit values (11% on average) than did microcapillary centrifugation. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2746654 Sat, 29 Aug 2009 23:00:00 +0100 2746654 http://www.medworm.com/index.php?rid=2746653&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01224.x Conclusion Treatment of plasma with the INTERCEPT Blood System preserves proteins necessary for haemostasis without inappropriate activation of coagulation, fibrinolytic or complement pathways. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2746653 Sat, 29 Aug 2009 23:00:00 +0100 2746653 http://www.medworm.com/index.php?rid=2728243&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01235.x Conclusions Pulmonary damage in TRALI is related to formation of cholesterol crystals that appear to pierce endothelial membranes of venules. The endothelial defects lead to plasma extravasation into the alveoli causing TRALI. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2728243 Mon, 24 Aug 2009 23:00:00 +0100 2728243 http://www.medworm.com/index.php?rid=2728244&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01241.x Conclusions The prevalence of RBC alloimmunization in transfused Ugandans was 6·1% and was associated with the number of donor exposures. This immunization rate is similar to that observed in transfused Caucasians despite differences in RBC antigen distributions. Patients with malaria were less likely to develop RBC alloantibodies. Alloantibodies were mainly against E and S antigens. We recommend the introduction of pretransfusion antibody tests in Uganda depending on the recipient's diagnosis. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2728244 Sun, 23 Aug 2009 23:00:00 +0100 2728244 http://www.medworm.com/index.php?rid=2714087&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01228.x Conclusion There is wide variability in transfusion practices to reduce the risk of TT-CMV. Lack of a consensus approach may reflect the conflicting data that exist in the literature as well as adherence to longstanding practice. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2714087 Wed, 19 Aug 2009 23:00:00 +0100 2714087 http://www.medworm.com/index.php?rid=2714086&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01239.x Conclusions The new proposed method, based on a double bag and storage freezer without liquid or gas phase nitrogen into a cryogenic chamber, significantly reduces bag rupture and bio-hazard and improves stem cell viability and neutrophil engraftment remarkably. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2714086 Wed, 19 Aug 2009 23:00:00 +0100 2714086 http://www.medworm.com/index.php?rid=2714085&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01233.x Conclusions Our data show that polymorphisms in the CD177 are associated with variations in the HNA-2 expression and may be the cause of atypical expressions. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2714085 Wed, 19 Aug 2009 23:00:00 +0100 2714085 http://www.medworm.com/index.php?rid=2704672&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01231.x Conclusion A significant proportion of postpartum RBC transfusions are possibly inappropriate, partly due to over-transfusion. If current guidelines would be more specific, in particular, with respect to the target Hb levels, the total amount of RBC transfusions may be considerably decreased. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2704672 Sun, 16 Aug 2009 23:00:00 +0100 2704672 http://www.medworm.com/index.php?rid=2672840&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01232.x Objective In an observational cohort study (2006[ndash]2007) the Paul-Ehrlich-Institut collected epidemiological data to investigate the frequency and causes of TRALI.Methods Diagnosis of TRALI was confirmed according to criteria of the European Haemovigilance Network. Subsequent testing of white blood cell antibodies (WBC-Ab) against HLA or human neutrophil alloantigens was performed.Results Of a total of 187 reported TRALI cases, 44 could be confirmed consisting of 35 cases of antibody-mediated TRALI and nine cases of non-immune-mediated TRALI. Eight of 44 affected patients (18%) had a fatal outcome, seven cases with WBC-Ab positive plasma donors and one case with red blood cell donors. WBC antibodies were found in one male and 39 female donors. In 34 female donors, a history of pregnanc... Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2672840 Wed, 05 Aug 2009 23:00:00 +0100 2672840 http://www.medworm.com/index.php?rid=2672839&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01222.x Conclusions A retrospective review of the medical case notes of the deceased recipients of vCJD-implicated blood components found no evidence that any further cases expressed clinical signs or symptoms suggestive of vCJD during life, but only four of the recipients survived for more than 5 years post-transfusion. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2672839 Wed, 05 Aug 2009 23:00:00 +0100 2672839 http://www.medworm.com/index.php?rid=2665322&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01134.x Conclusions Transfused ICU patients have a higher incidence of nosocomial infection and worse outcomes. Transfused patients had a shorter onset of infection. Acinetobacter infection appears to be particularly common among these patients. Further investigation is merited to better elucidate the mechanism for these findings and their therapeutic and clinical implications. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2665322 Mon, 03 Aug 2009 23:00:00 +0100 2665322 http://www.medworm.com/index.php?rid=2665321&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01218.x Discussion Analysis of test results of an external QC sample can be used as a statistical process control through ongoing measurement of imprecision. When laboratories test the same QC sample in the same assay and submit test results to a single database, the results can be compared and a measure of bias can be calculated. The resulting QC programme can offer detection of unexpected variation in the testing processes and the source of variation investigated. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2665321 Mon, 03 Aug 2009 23:00:00 +0100 2665321 http://www.medworm.com/index.php?rid=2665320&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01219.x Conclusions The MPX test on s 201 system is a fully automated NAT system suitable for routine blood donor screening. The analytical sensitivity as well as the diagnostic sensitivity fulfilled all requirements of the Paul Ehrlich Institute for blood donor screening in mini-pools up to 96 donations per pool. A major benefit of the automated NAT system is the reduced personnel time and the extensive complete barcode-controlled process documentation. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2665320 Mon, 03 Aug 2009 23:00:00 +0100 2665320 http://www.medworm.com/index.php?rid=2665319&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01221.x Conclusion Two of 158 transfusions of PCs released as 'negative to date', but with a confirmed positive BacT/ALERT result, were initially associated with transfusion reactions. However, the imputability of both reactions was low. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2665319 Mon, 03 Aug 2009 23:00:00 +0100 2665319 http://www.medworm.com/index.php?rid=2665318&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01223.x Therapeutic red blood cell (RBC) transfusion is widely utilized in the management of anaemia. Critically ill intensive care unit (ICU) patients in particular, as well as medical and haematology[ndash]oncology patients, are among the largest groups of users of RBC products. While anaemia is common in these patients, its treatment and management, including appropriate thresholds for RBC transfusion, remain controversial. We review here the function of RBCs in oxygen transport and physiology, with a view to their role in supporting and maintaining systemic tissue oxygenation. Adaptive and physiological compensatory mechanisms in the setting of anaemia are discussed, along with the limits of compensation. Finally, data from clinical studies will be examined in search of evidence for, or agains... Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2665318 Mon, 03 Aug 2009 23:00:00 +0100 2665318 http://www.medworm.com/index.php?rid=2663408&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01207.x Conclusion Increased awareness of the risks of iron overload from chronic transfusion therapy should result in greater use of interventions such as iron chelation to reduce total body iron and the risk of long-term sequelae. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2663408 Sun, 02 Aug 2009 23:00:00 +0100 2663408 http://www.medworm.com/index.php?rid=2663407&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.001215.x Conclusion The surgical treatment of ruptured ectopic pregnancy with intraperitoneal haemorrhage was rendered safe and efficient with this new salvaging equipment. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2663407 Sun, 02 Aug 2009 23:00:00 +0100 2663407 http://www.medworm.com/index.php?rid=2663406&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01227.x Mesenchymal Stem Cells/Multipotent Marrow Stromal Cells (MSC) are multipotent adult stem cells present in all tissues, as part of the perivascular population. As multipotent cells, MSCs can differentiate into different tissues originating from mesoderm ranging from bone and cartilage, to cardiac muscle. Conflicting data show that MSCs could be pluripotent and able to differentiate into tissues and cells of non-mesodermic origin as neurons or epithelial cells. Moreover, MSCs exhibit non-HLA restricted immunosuppressive properties. This wide range of properties leads to increasing uses of MSC for immunomodulation or tissue repair. Based on their immunosuppressive properties MSC are used particularly in the treatment of graft versus host disease, For tissue repair, MSCs can work by different ... Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2663406 Sun, 02 Aug 2009 23:00:00 +0100 2663406 http://www.medworm.com/index.php?rid=2651681&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01226.x This article reviews the developments that have led to modern IVIG preparations, the current methods used for plasma collection and fractionation, the safety measures implemented to minimize the risks of pathogen transmission and the major quality control tests that are available for product development and as part of mandatory batch release procedures. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2651681 Wed, 29 Jul 2009 23:00:00 +0100 2651681 http://www.medworm.com/index.php?rid=2642926&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01217.x Conclusion In vitro analysis allows comparison of the complement-inhibitory properties of IVIG preparations. The extent of complement scavenging varies between the products. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2642926 Mon, 27 Jul 2009 23:00:00 +0100 2642926 http://www.medworm.com/index.php?rid=2628197&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01225.x Conclusions Implementation of a uniform transfusion protocol for elective lower joint arthroplasty patients is feasible, but does not always lead to a RBC reduction. Length of hospital stay was not affected. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2628197 Wed, 22 Jul 2009 23:00:00 +0100 2628197 http://www.medworm.com/index.php?rid=2554244&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.001212.x Although the use of umbilical cord blood (UCB) for transfusion purposes has been proposed decades ago, the employ is still limited. In this article we review studies evaluating UCB collection efficiency and sterility, examine processing and storage of UCB-derived red blood cells (RBC) and discuss clinical studies in which UCB was used for transfusion purposes. Efforts to provide preterm newborns with autologous RBC derived from UCB have not been very successful. UCB collected after full-term deliveries can however easily be processed into RBC products and could be used autologous in case surgery of the neonate is indicated early after birth, or for allogeneic small volume paediatric transfusions. To harvest enough UCB volume, immediate clamping of the umbilical cord is commonly used as sta... Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2554244 Mon, 29 Jun 2009 23:00:00 +0100 2554244 http://www.medworm.com/index.php?rid=2554243&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.001213.x Conclusions The PCR-SBT method is reliable and accurate for HPA genotyping, suitable for routine HPA analysis, and can screen large numbers of donors. We identified 14 new polymorphisms, two of which led to amino acid changes. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2554243 Mon, 29 Jun 2009 23:00:00 +0100 2554243 http://www.medworm.com/index.php?rid=2554242&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.001214.x Conclusions Extra-binding of anti-C3 together with anti-idiotypic NAbs to senescent RBC-associated C3 fragments may suppress complement-dependent RBC phagocytosis and may prolong the in vivo life span of RBCs. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2554242 Mon, 29 Jun 2009 23:00:00 +0100 2554242 http://www.medworm.com/index.php?rid=2516087&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01211.x Conclusion The sequence analyses and the epidemiological data revealed that the plasma donor was most probably infected with a swine HEV. This case supports the ongoing discussion of an obligatory HEV nucleic acid testing of blood products for special recipient risk groups. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2516087 Thu, 25 Jun 2009 23:00:00 +0100 2516087 http://www.medworm.com/index.php?rid=2490659&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01203.x Conclusion Baseline expression of Fy antigen on mature red blood cells and reticulocytes is quite variable between individuals, but appears not to be greatly affected by mild to moderate reticulocytosis following blood loss in an autologous blood donation model. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2490659 Wed, 24 Jun 2009 23:00:00 +0100 2490659 http://www.medworm.com/index.php?rid=2490661&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01206.x Conclusion This new single-use, disposable PrPSc-harvesting gel ensures a very high capacity in terms of removing the pathogenic agent causing vCJD from the new generation OctaplasLG®, in the event that prions can be found in plasma from donors incubating the disease and thereby contaminating the raw material plasma used for manufacturing. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2490661 Sun, 21 Jun 2009 23:00:00 +0100 2490661 http://www.medworm.com/index.php?rid=2490660&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01209.x Blood group antigens, present on the cell membrane of red blood cells and platelets, can be defined either serologically or predicted based on the genotypes of genes encoding for blood group antigens. At present, the molecular basis of many antigens of the 30 blood group systems and 17 human platelet antigens is known. In many laboratories, blood group genotyping assays are routinely used for diagnostics in cases where patient red cells cannot be used for serological typing due to the presence of auto-antibodies or after recent transfusions. In addition, DNA genotyping is used to support (un)-expected serological findings. Fetal genotyping is routinely performed when there is a risk of alloimmune-mediated red cell or platelet destruction. In case of patient blood group antigen typing, it i... Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2490660 Sun, 21 Jun 2009 23:00:00 +0100 2490660 http://www.medworm.com/index.php?rid=2479760&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01205.x Conclusion It is unlikely that any of the UK vCJD clinical cases to date were infected through exposure to fractionated plasma products. However, the possibility that such transmission may result in vCJD cases in the future cannot be excluded. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2479760 Tue, 16 Jun 2009 04:00:00 +0100 2479760 http://www.medworm.com/index.php?rid=2479762&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01201.x Conclusion Our results show that different donor profiles can be distinguished. Differences between active and resigned donors include age, the number of donations, sex, socio-economic-status, ethnicity, and urbanization level. The factors highly associated with being a multi-gallon donor are sex, age, socio-economic status, and to a lesser extent urbanization level. Donor profiles do provide the blood bank with knowledge on their donor population, which may be used as valuable information for donor recruitment and retention policies. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2479762 Tue, 09 Jun 2009 04:00:00 +0100 2479762 http://www.medworm.com/index.php?rid=2479761&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01202.x Conclusion Acute citrate load resulted in profound alterations of the bone markers OC and CTX. The short-term increase of CTX suggests a temporary shift to a higher bone turnover rate, although the clinical consequence of the observed changes in bone markers remains open. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2479761 Tue, 09 Jun 2009 04:00:00 +0100 2479761 http://www.medworm.com/index.php?rid=2479764&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01198.x Conclusion Massive transfusion occurs rarely but has a high mortality and requires a disproportionate amount of blood products. An increased ratio of fresh frozen plasma to red blood cells was associated with improved outcome. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2479764 Wed, 03 Jun 2009 04:00:00 +0100 2479764 http://www.medworm.com/index.php?rid=2479763&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01200.x Conclusions In anaemic hip fracture patients managed with perioperative intravenous iron and restrictive transfusion protocol, preoperative administration of rHuEPO is associated with reduced ABT requirements. However, appropriate training, education and awareness are needed to avoid protocol violations and to limit further exposure to ABT and ABT-related risks. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2479763 Wed, 03 Jun 2009 04:00:00 +0100 2479763 http://www.medworm.com/index.php?rid=2479765&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01199.x Conclusion Misidentification at the bedside persists as the main cause of ABO-incompatible transfusion. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2479765 Wed, 20 May 2009 04:00:00 +0100 2479765 http://www.medworm.com/index.php?rid=2479768&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01196.x Conclusion PAS-G's novel presentation allows incorporation of glucose into the additive solution so that it is roughly equivalent to plasma for the maintenance of buffy-coat PCs. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2479768 Mon, 11 May 2009 04:00:00 +0100 2479768 http://www.medworm.com/index.php?rid=2479767&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01197.x Conclusion The advantage of an extension of platelet storage time beyond day 5 should be balanced against the increased need for platelet transfusions that may occur and the conceivable risk of transfusion failure. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2479767 Mon, 11 May 2009 04:00:00 +0100 2479767 http://www.medworm.com/index.php?rid=2479766&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01195.x We report two instances of human immunodeficiency virus (HIV) serological screening reactivity in blood donations which were subsequently determined to be due to donor participation in HIV vaccine trials. Both donations were screen reactive with atypical patterns on confirmation; no definitive conclusion could be given for either donor. Subsequent questioning identified that both donors had been involved in HIV vaccine trials. In both cases the screening and confirmation identified the presence of HIV antibodies, although vaccine induced. While clinical trials of vaccines are important, the implications of some need careful consideration if they are not to adversely impact other areas of healthcare. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2479766 Mon, 11 May 2009 04:00:00 +0100 2479766 http://www.medworm.com/index.php?rid=2479770&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01193.x Conclusion In comparison to PRT platelets resuspended in 100% plasma, a mixture of plasma and PAS improves pH and platelet metabolism but not platelet activation. Prolonged shelf-life for up to 7 days may be possible. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2479770 Mon, 27 Apr 2009 04:00:00 +0100 2479770 http://www.medworm.com/index.php?rid=2479769&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01194.x Conclusions The establishment of preparations 07/306, 07/308 and 07/310 as reference reagents by the World Health Organization will facilitate global standardization of haemagglutination tests for anti-A and anti-B, ensure that such tests are sufficiently sensitive and specific, and facilitate identification of batches that exceed maximum recommended levels of anti-A and anti-B. The Commission of the European Pharmacopoeia and the United States Food and Drug Administration have adopted the same reference reagents including the maximal specifications defined by preparation 07/310. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2479769 Mon, 27 Apr 2009 04:00:00 +0100 2479769 http://www.medworm.com/index.php?rid=2479771&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01186.x (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2479771 Thu, 23 Apr 2009 04:00:00 +0100 2479771 http://www.medworm.com/index.php?rid=2479775&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01183.x Conclusion By virtue of being a sensitive and accurate predictor of preharvest CD34+ counts, our data support the use of the HPC parameter in optimizing the timing of PBSC harvest. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2479775 Thu, 09 Apr 2009 04:00:00 +0100 2479775 http://www.medworm.com/index.php?rid=2479774&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01188.x Conclusions Similar methods for platelet gel preparation revealed different performances concerning growth factor recovery and the kinetics of its release from the gel. It is unclear whether these noticeable differences are important for clinical management. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2479774 Thu, 09 Apr 2009 04:00:00 +0100 2479774 http://www.medworm.com/index.php?rid=2479773&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01189.x Conclusion From these in vitro data, PC produced from buffy coats prepared using the Atreus appear suitable for clinical use, and WB may be held at ambient temperature overnight without the use of active cooling devices. Optimizing the secondary processing conditions to handle Atreus 2C+ derived BC may increase the platelet yield. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2479773 Thu, 09 Apr 2009 04:00:00 +0100 2479773 http://www.medworm.com/index.php?rid=2479772&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01190.x Conclusion The studies confirmed that the affinity ligand chromatography under the developed conditions can be introduced into the Octaplas® manufacturing process, as a mean to reduce potentially present PrPSc, without hampering the proven quality of this product. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2479772 Thu, 09 Apr 2009 04:00:00 +0100 2479772 http://www.medworm.com/index.php?rid=2479776&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01185.x Conclusion Blood group genotyping by DNA array contributes to the management of transfusions in SCD patients by facilitating the transfusion support with antigen-matched blood. It has the potential to improve the life of thousands of SCD-transfused patients by reducing mortality due to transfusion reactions and immunization. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2479776 Wed, 08 Apr 2009 04:00:00 +0100 2479776 http://www.medworm.com/index.php?rid=2490662&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01181.x Conclusion About 4·35% apparent D negative Chinese individuals were weak D or partial D, while 17·60% were DEL. Novel DEL alleles are rare, and all but 11 of the 279 DELs were due to the most common DEL allele, RHD (K409 K). The RHD 3G > A might be the second most frequent DEL allele in Chinese. Exploration of a complete molecular basis for DEL in Chinese ethnic groups is a long-term endeavour. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2490662 Sun, 29 Mar 2009 23:00:00 +0100 2490662 http://www.medworm.com/index.php?rid=2490663&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.01180.x Conclusion Standardized and functional virally inactivated HPGF can be prepared from human PC for possible applications in cell therapy and regenerative medicine. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2490663 Mon, 23 Mar 2009 00:00:00 +0100 2490663 http://www.medworm.com/index.php?rid=2251894&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19250133%26dopt%3DAbstract Authors: PMID: 19250133 [PubMed - in process] (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2251894 Wed, 11 Mar 2009 14:48:20 +0100 2251894 http://www.medworm.com/index.php?rid=2237066&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19254233%26dopt%3DAbstract Authors: Pottgiesser T, Schumacher YO, Funke H, Rennert K, Baumstark MW, Neunuebel K, Mosig S PMID: 19254233 [PubMed - as supplied by publisher] (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2237066 Tue, 24 Feb 2009 05:00:00 +0100 2237066 http://www.medworm.com/index.php?rid=2237065&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19254234%26dopt%3DAbstract Conclusions This study suggests that ABO-compatible non-identical plasma is less safe than identical plasma. Subanalyses by blood group suggest a role for circulating immune complexes. Our findings may have policy implications for improving transfusion safety. PMID: 19254234 [PubMed - as supplied by publisher] (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2237065 Tue, 24 Feb 2009 05:00:00 +0100 2237065 http://www.medworm.com/index.php?rid=2203308&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19228368%26dopt%3DAbstract Conclusion The proposed tests allow signalling of outlier centres and trends in incidence rates both at individual centre and at national levels. Graphical support and the use of as much relevant historical data as possible is recommended. The statistical tests described are generic and can be applied by any blood establishment and plasma fractionation institute. PMID: 19228368 [PubMed - as supplied by publisher] (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2203308 Tue, 17 Feb 2009 05:00:00 +0100 2203308 http://www.medworm.com/index.php?rid=2197469&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19220827%26dopt%3DAbstract This report of the International Society of Blood Transfusion Working Party on Transmissible Spongiform Encephalopathy will focus on the state of the art in relation to blood components and plasma safety. Latest information on the pathogenicity of the infectious agent, the frequency and dynamics of infection in blood and transfusion transmissibility will be documented. Preventive measures including donor deferral policies, technologies for prion removal from labile blood components and for prion detection in plasma, the absence of a sensitive and rapid reference assay able to confirm the positive results from any putative blood screening assay will be updated. At last, as many uncertainties remain and a number of assumptions await confirmation, the areas to continue to explore are listed. ... Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2197469 Tue, 10 Feb 2009 05:00:00 +0100 2197469 http://www.medworm.com/index.php?rid=2185655&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19215624%26dopt%3DAbstract Conclusions Substrate-related contributors to the highly variable phenotype and clinical course of TTP warrant further investigation. PMID: 19215624 [PubMed - as supplied by publisher] (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2185655 Tue, 10 Feb 2009 05:00:00 +0100 2185655 http://www.medworm.com/index.php?rid=2490664&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1423-0410.2009.001164.x Conclusions Substrate-related contributors to the highly variable phenotype and clinical course of TTP warrant further investigation. (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2490664 Tue, 10 Feb 2009 00:00:00 +0100 2490664 http://www.medworm.com/index.php?rid=2185656&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19215623%26dopt%3DAbstract Authors: Daniels G, van der Schoot CE, Gassner C, Olsson ML The Third International Society of Blood Transfusion Workshop on Molecular Blood Group Genotyping was held in 2008, with a feedback meeting at the International Society of Blood Transfusion Congress in Macao SAR, China. Thirty-three laboratories participated, eight less than in 2006. Six samples were distributed: sample 1 representing DNA from a sample referred because of abnormal serological results in D testing; samples 2 and 3 from transfusion-dependent patients for testing for all clinically important polymorphisms; sample 4 a mixture of two DNA samples designed to simulate a chimera, referred because of abnormal serological results in donor testing; and samples 5 and 6 plasma samples from RhD-negative pregnant women, for ... Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2185656 Mon, 09 Feb 2009 05:00:00 +0100 2185656 http://www.medworm.com/index.php?rid=2118484&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19152602%26dopt%3DAbstract Authors: Zimrin AB, Hess JR The development of blood storage systems allowed donation and transfusion to be separated in time and space. This separation has permitted the regionalization of donor services with subsequent economies of scale and improvements in the quality and availability of blood products. However, the availability of storage raises the question of how long blood products can and should be stored and how long they are safe and effective. The efficacy of red blood cells was originally measured as the increment in haematocrit and safety began with typing and the effort to reduce the risk of bacterial contamination. Appreciation of a growing list of storage lesions of red blood cells has developed with our increasing understanding of red blood cell physiology and our expe... Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2118484 Thu, 22 Jan 2009 03:59:24 +0100 2118484 http://www.medworm.com/index.php?rid=2118483&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19152603%26dopt%3DAbstract Conclusions In patients who experience massive bleeding, HCR with platelets and plasma, as guided by thrombelastography, is associated with improved survival. While confirmation from a randomized controlled trial is urgently needed, HCR may be considered in these patients. PMID: 19152603 [PubMed - in process] (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2118483 Thu, 22 Jan 2009 03:59:17 +0100 2118483 http://www.medworm.com/index.php?rid=2118482&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19152604%26dopt%3DAbstract Conclusion The results show that an elevated tHb induced by autologous transfusion allowed continuous identification although, as expected, a slow decrease of tHb has been revealed in the observation period. In reference to anti-doping, CO rebreathing permits proof of a supraphysiologically elevated tHb but possibly only if a stable baseline value is known. PMID: 19152604 [PubMed - in process] (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2118482 Thu, 22 Jan 2009 03:59:08 +0100 2118482 http://www.medworm.com/index.php?rid=2118481&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19152605%26dopt%3DAbstract Conclusion In this study, we demonstrated that a new Fc function assay incorporating frozen red blood cells, microtitre format and derivative analysis of haemolysis curves has been shown to be comparable to the standard BP procedure. It offers a more convenient and quicker means of performing analysis of Fc function of immunoglobulins. PMID: 19152605 [PubMed - in process] (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2118481 Thu, 22 Jan 2009 03:59:04 +0100 2118481 http://www.medworm.com/index.php?rid=2118480&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19152606%26dopt%3DAbstract Conclusion The present results show that the RCVRS provides a simple and easy-to-use process for obtaining red blood cell depletion and volume reduction of HUCB with good cell viability and recoveries. PMID: 19152606 [PubMed - in process] (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2118480 Thu, 22 Jan 2009 03:58:59 +0100 2118480 http://www.medworm.com/index.php?rid=2118479&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19152607%26dopt%3DAbstract Authors: Daniels G, Castilho L, Flegel WA, Fletcher A, Garratty G, Levene C, Lomas-Francis C, Moulds JM, Moulds JJ, Olsson ML, Overbeeke M, Poole J, Reid ME, Rouger P, van der Schoot E, Scott M, Sistonen P, Smart E, Storry JR, Tani Y, Yu LC, Wendel S, Westhoff C, Yahalom V, Zelinski T PMID: 19152607 [PubMed - in process] (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2118479 Thu, 22 Jan 2009 03:58:51 +0100 2118479 http://www.medworm.com/index.php?rid=2118478&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19152608%26dopt%3DAbstract Authors: Traore AN, Delage G, McCombie N, Robillard P, Heddle NM, Hyson C, Goldman M Transfusion of a bacterially contaminated blood product can have serious consequences. We undertook an electronic survey of representative Canadian hospitals to determine current clinical and laboratory practices for investigating such reactions, prior to the development of national guidelines. There was considerable variability in symptoms and signs that would trigger investigation of possible contamination. The most frequent laboratory investigations performed were aerobic blood cultures of recipients and the residual component. If there is no residual product in the component bag, 36% of respondents would use a segment to perform testing. Guidelines could be helpful in improving and standardizing th... Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2118478 Thu, 22 Jan 2009 03:58:42 +0100 2118478 http://www.medworm.com/index.php?rid=2118477&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19152609%26dopt%3DAbstract Authors: Davidson F, Yirrell DL, Lycett C, Petrik J, Dow BC The aim of our study was to determine human immunodeficiency virus 1 subtypes in Scottish blood donors. We were able to document virus subtypes present in this population over a period of 19 years and examine associated risk factors where available. Subtype B was found to be the predominant cause of human immunodeficiency virus 1 infection in Scottish blood donors with subtype C increasing in this population after 2002. Non-B subtypes were found mainly in heterosexuals but also in all other risk categories with the exception of men having sex with men (MSM). Within Scotland there is an increase in transmission via heterosexual contact and the consequential introduction of non-B subtypes. PMID: 19152609 [PubMed - in process... Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2118477 Thu, 22 Jan 2009 03:58:34 +0100 2118477 http://www.medworm.com/index.php?rid=2118476&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19152610%26dopt%3DAbstract Conclusion Leucocyte depletion within 10 h of blood donation will reduce the concentrations of pyrogenic mediators. PMID: 19152610 [PubMed - in process] (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2118476 Thu, 22 Jan 2009 03:58:24 +0100 2118476 http://www.medworm.com/index.php?rid=2118475&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19152611%26dopt%3DAbstract Authors: Valeri CR, Ragno G PMID: 19152611 [PubMed - in process] (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2118475 Thu, 22 Jan 2009 03:58:21 +0100 2118475 http://www.medworm.com/index.php?rid=2118474&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19152612%26dopt%3DAbstract On the quality of transfused packed red blood cell concentrates in Trauma Registry of the Deutsche Gesellschaft für Unfallchirurgie-affiliated centres and hospitals. Vox Sang. 2009 Feb;96(2):181 Authors: Maegele M, Bauerfeind U PMID: 19152612 [PubMed - in process] (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2118474 Thu, 22 Jan 2009 03:58:14 +0100 2118474 http://www.medworm.com/index.php?rid=2082523&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19121192%26dopt%3DAbstract Authors: Muñoz M, García-Erce JA, Villar I, Thomas D Several major orthopaedic surgical procedures may result in significant blood loss and the need for allogeneic blood transfusion (ABT). However, overall concerns about adverse effects of ABT have prompted the review of transfusion practice and the search for transfusion alternatives to decrease or avoid the use of ABT. These strategies include the correction of perioperative anaemia, pharmacological and non-pharmacologic measures to reduce blood loss, preoperative autologous blood donation and perioperative red blood cell salvage. We have reviewed the efficacy and safety of these strategies and where appropriate offer evidence-based recommendations on their use in orthopaedic surgery. We also reviewed the European regulatio... Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2082523 Thu, 01 Jan 2009 05:00:00 +0100 2082523 http://www.medworm.com/index.php?rid=2082522&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19121193%26dopt%3DAbstract Conclusion Heat treatment and high hydrostatic pressure treatment revealed differences in inactivation efficiencies among cell-adapted HAV strains, and each strain reacted differently depending on the treatment. KRM238 may be the best candidate for virus validation to ensure the safety of blood products against viral contamination, as it is harder to inactivate and it replicates better in cell culture than the other strains. PMID: 19121193 [PubMed - in process] (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2082522 Thu, 01 Jan 2009 05:00:00 +0100 2082522 http://www.medworm.com/index.php?rid=2082521&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19121194%26dopt%3DAbstract Conclusion The study provides essential data regarding the extent and risk factors for non-compliance of HCV-positive blood donors with recommendation to seek medical advice. Our results can assist in identifying blood donors who would not seek counselling, based on demographic factors and past exposure to risk factors for HCV. Improvements in the notification process and additional training of general practitoners regarding the management of HCV disease are needed. PMID: 19121194 [PubMed - in process] (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2082521 Thu, 01 Jan 2009 05:00:00 +0100 2082521 http://www.medworm.com/index.php?rid=2082520&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19121195%26dopt%3DAbstract Conclusion There are no significant differences between the two preparation methods regarding the clinical outcome of platelet transfusions, as the difference in 1-h CI is explained by differences in platelet content. PMID: 19121195 [PubMed - in process] (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2082520 Thu, 01 Jan 2009 05:00:00 +0100 2082520 http://www.medworm.com/index.php?rid=2082519&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19121196%26dopt%3DAbstract Conclusion Adult ECMO patients with lower Hb(nadir) require more daily red blood cell and FFP. Hypertension increases daily FFP requirements. Recent antiplatelet agents, larger Hb decline and longer ECMO duration increase daily platelet requirements. Patients with sepsis or on ECMO for medical reasons have longer ECMO duration, which is associated with total transfusion requirements. Some of these factors may be identified early to optimize blood product support. PMID: 19121196 [PubMed - in process] (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2082519 Thu, 01 Jan 2009 05:00:00 +0100 2082519 http://www.medworm.com/index.php?rid=2082518&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19121197%26dopt%3DAbstract Conclusion Oxygen transport rate increases during storage; blood units with similar haemoglobin content may have significant differences in OTR. Studies examining blood parameters at the time of donation and blood storage on patient outcomes should consider measuring OTR, as it may contribute to differences in observed efficacy of tissue oxygenation. PMID: 19121197 [PubMed - in process] (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2082518 Thu, 01 Jan 2009 05:00:00 +0100 2082518 http://www.medworm.com/index.php?rid=2082517&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19121198%26dopt%3DAbstract Conclusion Iron status of women who want to serve as blood donors has deteriorated in the last 10 years, leading to an increased rejection due to haemoglobin below the inclusion criterion for blood donors. PMID: 19121198 [PubMed - in process] (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2082517 Thu, 01 Jan 2009 05:00:00 +0100 2082517 http://www.medworm.com/index.php?rid=2082516&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19121199%26dopt%3DAbstract Conclusion The major glycolipid difference between the A(1) and A(2) phenotypes is the dominance of A type 4 glycolipids in the A(1) phenotype. PMID: 19121199 [PubMed - in process] (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2082516 Thu, 01 Jan 2009 05:00:00 +0100 2082516 http://www.medworm.com/index.php?rid=2082515&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19121200%26dopt%3DAbstract Authors: New HV, Stanworth SJ, Engelfriet CP, Reesink HW, McQuilten ZK, Savoia HF, Wood EM, Olyntho S, Trigo F, Wendel S, Lin Y, Hume H, Petäjä J, Krusius T, Villa S, Ghirardello S, von Lindern J, Brand A, Hendrickson JE, Josephson CD, Strauss RG, Luban NL, Paul W PMID: 19121200 [PubMed - in process] (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2082515 Thu, 01 Jan 2009 05:00:00 +0100 2082515 http://www.medworm.com/index.php?rid=2082514&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19121201%26dopt%3DAbstract Authors: PMID: 19121201 [PubMed - in process] (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2082514 Thu, 01 Jan 2009 05:00:00 +0100 2082514 http://www.medworm.com/index.php?rid=2082513&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19121202%26dopt%3DAbstract Authors: Armstrong B PMID: 19121202 [PubMed - in process] (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2082513 Thu, 01 Jan 2009 05:00:00 +0100 2082513 http://www.medworm.com/index.php?rid=2044212&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19076337%26dopt%3DAbstract Conclusion The implementation of leucoreduction did not modify the blood HTLV-screening policy, except for Norway and Finland. Several screening strategies in low endemic countries performing leucoreduction were discussed. However, the withdrawal of anti-HTLV screening should be decided after assessing the remaining HTLV transfusion risk. PMID: 19076337 [PubMed - as supplied by publisher] (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2044212 Fri, 05 Dec 2008 05:00:00 +0100 2044212 http://www.medworm.com/index.php?rid=2044211&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19076338%26dopt%3DAbstract Authors: Davenport RD Chemokines are a set of structurally related peptides that were first characterized as chemoattractants and have subsequently been shown to have many functions in homeostasis and pathophysiology. Diversity and redundancy of chemokine function is imparted by both selectivity and overlap in the specificity of chemokine receptors for their ligands. Chemokines have roles impacting transfusion medicine in haematopoiesis, haematologic malignancies, transfusion reactions, graft-versus-host disease, and viral infections. In haematopoietic cell transplantation, chemokines are active in mobilization and homing of progenitor cells, as well as mediating T-cell recruitment in graft-versus-host disease. Platelets are rich source of chemokines that recruit and activate leucocyte... Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2044211 Fri, 05 Dec 2008 05:00:00 +0100 2044211 http://www.medworm.com/index.php?rid=2044210&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19076339%26dopt%3DAbstract Conclusions When diluted 1 in 2, most laboratories were able to detect the presence of anti-HPA-1a in both materials and the participants agreed that this was an appropriate level to set as the minimum sensitivity required. In October 2007, the World Health Organization Expert Committee on Biological Standardization approved the material 05/106 as an International Reference Reagent. PMID: 19076339 [PubMed - as supplied by publisher] (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2044210 Fri, 05 Dec 2008 05:00:00 +0100 2044210 http://www.medworm.com/index.php?rid=2044216&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19076333%26dopt%3DAbstract Conclusion The nucleotide 340C>T change in RHCE exon 3 (predicted to encode 114Trp) of the RHCE*ce(S)(340) allele is associated with a JAL+ phenotype and the altered expression of the c, V and VS antigens. This alteration in the c antigen allowed the patient to make an alloanti-c. This case reveals that the RHCE*ce(S)(340) allele encodes a partial c antigen. PMID: 19076333 [PubMed - as supplied by publisher] (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2044216 Thu, 04 Dec 2008 05:00:00 +0100 2044216 http://www.medworm.com/index.php?rid=2044215&cid=s_29472_19_f&fid=29472&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19076334%26dopt%3DAbstract Conclusion Pre-storage leucoreduction for autologous blood may be effective to suppress cytokine accumulation. However, clinical benefits such as prevention of febrile non-haemolytic reactions could not be demonstrated. PMID: 19076334 [PubMed - as supplied by publisher] (Source: Vox Sanguinis) Vox Sanguinis journals http://www.medworm.com/rss/comments.php?id=2044215 Thu, 04 Dec 2008 05:00:00 +0100 2044215