MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'World Journal of Gastroenterology' source. Wed, 27 Jan 2010 14:17:55 +0100 http://www.medworm.com/index.php?rid=3127054&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20037627%26dopt%3DAbstract Authors: Talley NJ PMID: 20037627 [PubMed - as supplied by publisher] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=3127054 Sat, 28 Nov 2009 00:00:00 +0100 3127054 http://www.medworm.com/index.php?rid=2793738&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19750565%26dopt%3DAbstract Authors: Pillai AA, Levitsky J Continued advances in surgical techniques and immunosuppressive therapy have allowed liver transplantation to become an extremely successful treatment option for patients with end-stage liver disease. Beginning with the revolutionary discovery of cyclosporine in the 1970s, immunosuppressive regimens have evolved greatly and current statistics confirm one-year graft survival rates in excess of 80%. Immunosuppressive regimens include calcineurin inhibitors, anti-metabolites, mTOR inhibitors, steroids and antibody-based therapies. These agents target different sites in the T cell activation cascade, usually by inhibiting T cell activation or via T cell depletion. They are used as induction therapy in the immediate peri- and post-operative period, as long-ter... World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2793738 Sun, 13 Sep 2009 23:00:00 +0100 2793738 http://www.medworm.com/index.php?rid=2793737&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19750566%26dopt%3DAbstract Authors: Lakatos PL Inflammatory bowel diseases (IBD) are chronic diseases with a relapsing-remitting disease course necessitating lifelong treatment. However, non-adherence has been reported in over 40% of patients, especially those in remission taking maintenance therapies for IBD. The economical impact of non-adherence to medical therapy including absenteeism, hospitalization risk, and the health care costs in chronic conditions, is enormous. The causes of medication non-adherence are complex, where the patient-doctor relationship, treatment regimen, and other disease-related factors play key roles. Moreover, subjective assessment might underestimate adherence. Poor adherence may result in more frequent relapses, a disabling disease course, in ulcerative colitis, and an increased ri... World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2793737 Sun, 13 Sep 2009 23:00:00 +0100 2793737 http://www.medworm.com/index.php?rid=2793736&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19750567%26dopt%3DAbstract Authors: Aljiffry M, Walsh MJ, Molinari M Several advances in diagnosis, treatment and palliation of cholangiocarcinoma (CC) have occurred in the last decades. A multidisciplinary approach to this disease is therefore recommended. CC is a relatively rare tumor and the main risk factors are: chronic inflammation, genetic predisposition and congenital abnormalities of the biliary tree. While the incidence of intra-hepatic CC is increasing, the incidence of extra-hepatic CC is trending down. The only curative treatment for CC is surgical resection with negative margins. Liver transplantation has been proposed only for selected patients with hilar CC that cannot be resected who have no metastatic disease after a period of neoadjuvant chemo-radiation therapy. Magnetic resonance imaging/magn... World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2793736 Sun, 13 Sep 2009 23:00:00 +0100 2793736 http://www.medworm.com/index.php?rid=2793735&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19750568%26dopt%3DAbstract Authors: Taxonera C, Schwartz DA, García-Olmo D Complex perianal fistulas have a negative impact on the quality of life of sufferers and should be treated. Correct diagnosis, characterization and classification of the fistulas are essential to optimize treatment. Nevertheless, in the case of patients whose fistulas are associated with Crohn's disease, complete closure is particularly difficult to achieve. Systemic medical treatments (antibiotics, thiopurines and other immunomodulatory agents, and, more recently, anti-tumor necrosis factor-alpha agents such as infliximab) have been tried with varying degrees of success. Combined medical (including infliximab) and less aggressive surgical therapy (drainage and seton placement) offer the best outcomes in complex Crohn's fistulas whil... World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2793735 Sun, 13 Sep 2009 23:00:00 +0100 2793735 http://www.medworm.com/index.php?rid=2793734&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19750569%26dopt%3DAbstract CONCLUSION: EMR is an effective technique for the resection of large colorectal polyps and offers an alternative to surgery. PMID: 19750569 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2793734 Sun, 13 Sep 2009 23:00:00 +0100 2793734 http://www.medworm.com/index.php?rid=2793733&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19750570%26dopt%3DAbstract CONCLUSION: The combination regimen of 5-Fluorouracil, irinotecan, bevacizumab and sirolimus in advanced colorectal carcinoma after failure of classical treatment is feasible and promising. Further evaluation of this combination is required. PMID: 19750570 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2793733 Sun, 13 Sep 2009 23:00:00 +0100 2793733 http://www.medworm.com/index.php?rid=2793732&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19750571%26dopt%3DAbstract CONCLUSION: Early propranolol's administration in portal hypertensive cirrhotic rats seems to prevent intense gastric vascular congestion that characterizes portal hypertensive gastropathy. PMID: 19750571 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2793732 Sun, 13 Sep 2009 23:00:00 +0100 2793732 http://www.medworm.com/index.php?rid=2793731&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19750572%26dopt%3DAbstract CONCLUSION: H pylori eradication therapy for peptic ulcer patients with a mean age of 52.9 years at registration did not significantly decrease the incidence of gastric cancer. PMID: 19750572 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2793731 Sun, 13 Sep 2009 23:00:00 +0100 2793731 http://www.medworm.com/index.php?rid=2793730&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19750573%26dopt%3DAbstract CONCLUSION: SES + ELBD did not show significant benefits compared to conventional EST, especially for the removal of large (>/= 15 mm) bile duct stones. PMID: 19750573 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2793730 Sun, 13 Sep 2009 23:00:00 +0100 2793730 http://www.medworm.com/index.php?rid=2793729&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19750574%26dopt%3DAbstract CONCLUSION: S-PAC patients should not be regarded as early PAC. Only higher albumin level (> 3.5 g/dL) and early stage disease (stage I, II) were the favorable prognosis factors for S-PAC patients. PMID: 19750574 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2793729 Sun, 13 Sep 2009 23:00:00 +0100 2793729 http://www.medworm.com/index.php?rid=2793728&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19750575%26dopt%3DAbstract CONCLUSION: Baseline serum ALT, TSH, and TT4 levels, especially in combination, have high predictive values of virological response to Peginterferon alpha-2b in HBeAg-positive CHB patients. PMID: 19750575 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2793728 Sun, 13 Sep 2009 23:00:00 +0100 2793728 http://www.medworm.com/index.php?rid=2793727&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19750576%26dopt%3DAbstract CONCLUSION: The expression of TS and of GST-pi may be used as molecular markers for the characterization of ESCC. Poorly-differentiated cells showed increased expression of TS and reduced expression of GST-pi. PMID: 19750576 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2793727 Sun, 13 Sep 2009 23:00:00 +0100 2793727 http://www.medworm.com/index.php?rid=2793726&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19750577%26dopt%3DAbstract CONCLUSION: Endoscopic hemoclip application was an effective and safe method for acute nonvariceal bleeding in the upper GI tract with satisfactory outcomes. PMID: 19750577 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2793726 Sun, 13 Sep 2009 23:00:00 +0100 2793726 http://www.medworm.com/index.php?rid=2793725&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19750578%26dopt%3DAbstract This report highlights the importance of accurate histological diagnosis and clinical follow-up of lupus patients with GI symptoms undergoing intense immunosuppression. PMID: 19750578 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2793725 Sun, 13 Sep 2009 23:00:00 +0100 2793725 http://www.medworm.com/index.php?rid=2793724&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19750579%26dopt%3DAbstract Authors: Wotton FT, Akoh JA Permacol(R) mesh has shown promise when used in abdominal wall repair, especially in the presence of a contaminated surgical field. This biomaterial, derived from porcine dermis collagen, has proposed advantages over synthetic materials due to increased biocompatibility and reduced foreign body reaction within human tissues. However, we present a case report describing a patient who displayed rejection to a Permacol(R) mesh when used in the repair of abdominal wound dehiscence following an emergency laparotomy. Review of the English language literature using PubMed and Medline, showed only two previously published cases of explantation of Permacol(R) due to sepsis or wound breakdown. The authors believe this is the first case of severe foreign body reaction ... World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2793724 Sun, 13 Sep 2009 23:00:00 +0100 2793724 http://www.medworm.com/index.php?rid=2793723&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19750580%26dopt%3DAbstract Authors: Poves I, Burdío F, Iglesias M, Martínez-Serrano MA, Aguilar G, Grande L A 33-year-old woman who presented with epigastric discomfort and diarrhea underwent an abdominal ultrasound (US). This investigation and subsequent contrast-enhanced computed tomography, magnetic resonance imaging and endoscopic US with fine needle aspiration (FNA) revealed a 40 mm well-circumscribed mass in the uncinate process of the pancreas. Findings were suggestive of a mucinous or solid-cystic pseudopapillary tumor of the pancreas, although other lesions such as a non-functioning neuroendocrine tumor could not be ruled out. FNA samples were negative for malignant cells, but of limited value due to poor cellularity. It was decided to surgically remove the tumor because malignancy could not b... World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2793723 Sun, 13 Sep 2009 23:00:00 +0100 2793723 http://www.medworm.com/index.php?rid=2793722&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19750581%26dopt%3DAbstract We report a Thai female infant who presented with progressive cholestatic jaundice since 1 mo of age, with normal serum gamma-glutamyltransferase. Immunohistochemical staining of the liver did not demonstrate BSEP along the canaliculi, while multidrug resistance protein 3 was expressed adequately. Novel mutations in ABCB11, a four-nucleotide deletion in exon 3, c.90_93delGAAA, and a single-nucleotide insertion in exon 5, c.249_250insT, were identified, with confirmation in her parents. These mutations were predicted to lead to synthesis of truncated forms of BSEP. Immunostaining and mutation analysis thus established the diagnosis of PFIC type 2. PMID: 19750581 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2793722 Sun, 13 Sep 2009 23:00:00 +0100 2793722 http://www.medworm.com/index.php?rid=2793721&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19750582%26dopt%3DAbstract Authors: Lai LH, Romagnuolo J, Adams D, Yang J Squamous cell carcinoma of the pancreas has been sparsely described since the 1940s, and generally has a poor prognosis. Herein, we present a case of primary squamous cell carcinoma of the pancreas with liver metastasis, both confirmed by endoscopic ultrasound-guided fine needle aspiration (EUS-FNA). To the best of our knowledge, this is the first case report in literature utilizing EUS-FNA for a cell-type specific diagnosis of primary pancreatic squamous cell carcinoma with a liver metastasis. PMID: 19750582 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2793721 Sun, 13 Sep 2009 23:00:00 +0100 2793721 http://www.medworm.com/index.php?rid=2793720&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19750583%26dopt%3DAbstract Authors: Yilmaz Y, Dolar E In light of the growing epidemics of nonalcoholic fatty liver disease (NAFLD), identification and validation of the novel biochemical surrogate markers for nonalcoholic steatohepatitis (NASH) are paramount to reduce the necessity for liver biopsy. The availability of such markers has tremendous potential to radically alter the management strategies of NAFLD patients and to monitor the disease activity. Although current biomarkers do not entirely fulfill the many requirements for the identification of patients with NASH, they should not discourage our quest, but remind us that we need to cognize the challenges ahead. PMID: 19750583 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2793720 Sun, 13 Sep 2009 23:00:00 +0100 2793720 http://www.medworm.com/index.php?rid=2533870&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%2520%28%2522World%2520J%2520Gastroenterol%2522%255Bta%255D%29%2520AND%2520%25222009%252F04%252F07%252023.54%2522%255BEDAT%255D%253A%25222009%252F06%252F27%252013.19%2522%255BEDAT%255D%29 221 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "World J Gastroenterol"[ta] These pubmed results were generated on 2009/06/27PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2533870 Sat, 27 Jun 2009 17:19:02 +0100 2533870 http://www.medworm.com/index.php?rid=2309597&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19325896%26dopt%3DAbstract Authors: Osna NA PMID: 19325896 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2309597 Sat, 14 Mar 2009 04:00:00 +0100 2309597 http://www.medworm.com/index.php?rid=2221104&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19248187%26dopt%3DAbstract This article reviews the epidemiology, pathophysiology, diagnosis, and management of liver diseases seen in pregnancy. PMID: 19248187 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2221104 Sat, 28 Feb 2009 05:00:00 +0100 2221104 http://www.medworm.com/index.php?rid=2221103&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19248188%26dopt%3DAbstract This article reviews the clinical application of hepatic x-ray computed tomography perfusion in some liver diseases. PMID: 19248188 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2221103 Sat, 28 Feb 2009 05:00:00 +0100 2221103 http://www.medworm.com/index.php?rid=2221102&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19248189%26dopt%3DAbstract CONCLUSION: This rabbit model produces the key features of pediatric NASH and may provide a realistic model for future studies. Adiponectin level partially reflects the severity of liver steatosis, but not the degree of liver inflammation. PMID: 19248189 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2221102 Sat, 28 Feb 2009 05:00:00 +0100 2221102 http://www.medworm.com/index.php?rid=2221101&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19248190%26dopt%3DAbstract CONCLUSION: Although aspirin increases the susceptibility of H pylori to metronidazole, it has no effect on the mutations of rdxA gene of H pylori. Aspirin increases endocellular concentrations of antimicrobials probably by altering the OMP expression. PMID: 19248190 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2221101 Sat, 28 Feb 2009 05:00:00 +0100 2221101 http://www.medworm.com/index.php?rid=2221100&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19248191%26dopt%3DAbstract CONCLUSION: Patients with ulcerative colitis who do not undergo an operation during their hospitalization have similar or higher rates of thromboembolism than other medical patients who are considered to be high risk for thromboembolism. PMID: 19248191 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2221100 Sat, 28 Feb 2009 05:00:00 +0100 2221100 http://www.medworm.com/index.php?rid=2221099&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19248192%26dopt%3DAbstract CONCLUSION: Three months of pantoprazole therapy induced ultrastructural healing of mucosal damage in 89% and 93% of ERD and non-erosion patients, respectively. Moreover, long-term pantoprazole treatment may be helpful in increasing the capability for esophageal cell proliferation in GERD, particularly in ERD patients. PMID: 19248192 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2221099 Sat, 28 Feb 2009 05:00:00 +0100 2221099 http://www.medworm.com/index.php?rid=2221098&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19248193%26dopt%3DAbstract CONCLUSION: Angiotensin receptor blockers seem to be efficient in hypertension-associated NASH. Telmisartan showed a higher efficacy regarding insulin resistance and histology, perhaps because of its specific PPAR-gamma ligand effect. PMID: 19248193 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2221098 Sat, 28 Feb 2009 05:00:00 +0100 2221098 http://www.medworm.com/index.php?rid=2221097&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19248194%26dopt%3DAbstract CONCLUSION: Homocysteine levels are dependent on Marsh classification and the regular use of B-vitamin supplements is effective in reduction of homocysteine levels in patients with celiac disease and should be considered in disease management. PMID: 19248194 [PubMed - as supplied by publisher] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2221097 Sat, 28 Feb 2009 05:00:00 +0100 2221097 http://www.medworm.com/index.php?rid=2221096&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19248195%26dopt%3DAbstract CONCLUSION: The prevalence of GERD (33%) is very high in Qashqai migrating nomads which may be due to a lower socioeconomic and educational level of these people and difference in the life style. Older age, frequent consumption of fruits and vegetables, smoking and NSAIDs are risk factors for GERD in this population. PMID: 19248195 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2221096 Sat, 28 Feb 2009 05:00:00 +0100 2221096 http://www.medworm.com/index.php?rid=2221095&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19248196%26dopt%3DAbstract CONCLUSION: The (13)C-MBT provides a rapid, non-invasive assessment of liver function in acute severe liver disease of diverse etiologies. The results of this pilot clinical trial suggest that the MBT may offer greater sensitivity than standard clinical tests for managing patients with severe acute liver disease. PMID: 19248196 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2221095 Sat, 28 Feb 2009 05:00:00 +0100 2221095 http://www.medworm.com/index.php?rid=2221094&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19248197%26dopt%3DAbstract CONCLUSION: These results suggest that EA-mediated protection against ASA-induced ulceration in rats may occur via gastric defense components. PMID: 19248197 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2221094 Sat, 28 Feb 2009 05:00:00 +0100 2221094 http://www.medworm.com/index.php?rid=2221093&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19248198%26dopt%3DAbstract CONCLUSION: Surgical palliation does not increase the morbidity or mortality rates, but it does increase the survival rate and improve the quality of life in elderly patients with unresectable pancreatic head cancer. PMID: 19248198 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2221093 Sat, 28 Feb 2009 05:00:00 +0100 2221093 http://www.medworm.com/index.php?rid=2221092&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19248199%26dopt%3DAbstract CONCLUSION: Scientific and rational detection strategy can improve the detection rate of HNPCC. Based on traditional molecular genetics and combined with epigenetics, multiple detection methods can accurately diagnose HNPCC. PMID: 19248199 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2221092 Sat, 28 Feb 2009 05:00:00 +0100 2221092 http://www.medworm.com/index.php?rid=2221091&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19248200%26dopt%3DAbstract CONCLUSION: Esomeprazole may be more effective than omeprazole, lansoprazole, and pantoprazole for the rapid relief of heartburn symptoms and acid reflux symptoms in patients with reflux esophagitis. PMID: 19248200 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2221091 Sat, 28 Feb 2009 05:00:00 +0100 2221091 http://www.medworm.com/index.php?rid=2221090&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19248201%26dopt%3DAbstract CONCLUSION: Without highly active antiretroviral therapies (HAART), HIV accelerates HCV disease progression, including death, histological fibrosis/cirrhosis and decompensated liver disease. However, the rate of hepatocellular carcinoma is similar in persons who had HCV infection and were positive for HIV or negative for HIV. PMID: 19248201 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2221090 Sat, 28 Feb 2009 05:00:00 +0100 2221090 http://www.medworm.com/index.php?rid=2221089&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19248202%26dopt%3DAbstract We report a case of severe AIH following varicella zoster infection in a 23-year-old man, and speculate that, based on the molecular mimicry hypothesis, the liver damage was caused by an immune cross reaction to the viral proteins. Varicella-zoster-induced AIH has not been reported previously. PMID: 19248202 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2221089 Sat, 28 Feb 2009 05:00:00 +0100 2221089 http://www.medworm.com/index.php?rid=2221088&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19248203%26dopt%3DAbstract Authors: Ikeda S, Takeda H, Yoshimitsu M, Hinoi T, Yoshida M, Sumitani D, Takakura Y, Kawaguchi Y, Shimomura M, Tokunaga M, Kawahori K, Ohdan H, Okajima M In this paper, we report an extremely rare case of an abscess that developed in the inguinal hernial sac after surgery for peritonitis. A 60-year-old man underwent laparoscopic low anterior resection for rectal cancer. One day after this operation, peritoneal drainage and ileostomy were performed for rectal anastomotic leakage. Five days after the second operation, computed tomography revealed an abscess in the left inguinal hernial sac. Subsequently, hernioplasty and resection of the inflamed sac were performed. PMID: 19248203 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2221088 Sat, 28 Feb 2009 05:00:00 +0100 2221088 http://www.medworm.com/index.php?rid=2221087&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19248204%26dopt%3DAbstract We report a patient who had solitary pancreatic tuberculosis masquerading as pancreatic serous cystadenoma. PMID: 19248204 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2221087 Sat, 28 Feb 2009 05:00:00 +0100 2221087 http://www.medworm.com/index.php?rid=2221086&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19248205%26dopt%3DAbstract In this report, a literature review of liver lesions involving multiple myeloma is also provided. PMID: 19248205 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2221086 Sat, 28 Feb 2009 05:00:00 +0100 2221086 http://www.medworm.com/index.php?rid=2221085&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19248206%26dopt%3DAbstract Authors: Kapoor S The recent article by Zhou et al was highly interesting and thought provoking. The authors have clearly shown that triptolide administration is associated with up-regulation of the Bax gene, resulting in an attenuating effect on cell growth in gastrointestinal malignancies such as pancreatic carcinomas. The article by Zhou et al is all the more important because it highlights the rapidly increasing role of triplodide in the management of systemic malignancies. For instance, triptolide acts on the PI3K/Akt/NF-kappaB pathway, thereby enhancing apoptosis secondary to the administration of bortezomib in multiple myeloma cells. Similar synergisms are seen when triptolide is administered along with 5-fluoruracil for the management of colonic carcinomas. Similarly, triptolid... World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2221085 Sat, 28 Feb 2009 05:00:00 +0100 2221085 http://www.medworm.com/index.php?rid=2204005&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19230038%26dopt%3DAbstract Authors: Holder-Murray J, Fichera A Preservation of the anal transition zone has long been a significant source of controversy in the surgical management of ulcerative colitis. The two techniques for restorative proctocolectomy and ileal pouch anal anastomosis (RPC IPAA) in common practice are a stapled anastomosis and a handsewn anastomosis; these techniques differ in the amount of remaining rectal mucosa and therefore the presence of the anal transition zone following surgery. Each technique has advantages and disadvantages in long-term functional outcomes, operative and postoperative complications, and risk of neoplasia. Therefore, we propose a selective approach to performing a stapled RPC IPAA based on the presence of dysplasia in the preoperative endoscopic evaluation. PMID: ... World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2204005 Sat, 21 Feb 2009 05:00:00 +0100 2204005 http://www.medworm.com/index.php?rid=2204004&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19230039%26dopt%3DAbstract Authors: Drozdowski LA, Clandinin MT, Thomson AB The process of intestinal adaptation ("enteroplasticity") is complex and multifaceted. Although a number of trophic nutrients and non-nutritive factors have been identified in animal studies, successful, reproducible clinical trials in humans are awaited. Understanding mechanisms underlying this adaptive process may direct research toward strategies that maximize intestinal function and impart a true clinical benefit to patients with short bowel syndrome, or to persons in whom nutrient absorption needs to be maximized. In this review, we consider the morphological, kinetic and membrane biochemical aspects of enteroplasticity, focus on the importance of nutritional factors, provide an overview of the many hormones that may alter the adapt... World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2204004 Sat, 21 Feb 2009 05:00:00 +0100 2204004 http://www.medworm.com/index.php?rid=2204003&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19230040%26dopt%3DAbstract Authors: Yun J, Xu CT, Pan BR Inflammatory bowel disease (IBD) includes two similar yet distinct conditions called ulcerative colitis (UC) and Crohn's disease (CD). These diseases affect the digestive system and cause the inflammation of intestinal tissue, form sores and bleed easily. Most children with IBD are diagnosed in late childhood and adolescence. However, both UC and CD have been reported as early as in infancy. Most information pertaining to the epidemiology of IBD is based upon adult studies. Symptoms include abdominal pain, cramping, fatigue and diarrhea. Genetic factors play a significant role in determining IBD susceptibility. Epidemiological data support a genetic contribution to the pathogenesis of IBD. Recently, numerous new genes have been identified as being involved... World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2204003 Sat, 21 Feb 2009 05:00:00 +0100 2204003 http://www.medworm.com/index.php?rid=2204002&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19230041%26dopt%3DAbstract Authors: Monte MJ, Marin JJ, Antelo A, Vazquez-Tato J The family of bile acids includes a group of molecular species of acidic steroids with very peculiar physical-chemical and biological characteristics. They are synthesized by the liver from cholesterol through several complementary pathways that are controlled by mechanisms involving fine-tuning by the levels of certain bile acid species. Although their best-known role is their participation in the digestion and absorption of fat, they also play an important role in several other physiological processes. Thus, genetic abnormalities accounting for alterations in their synthesis, biotransformation and/or transport may result in severe alterations, even leading to lethal situations for which the sole therapeutic option may be liver tra... World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2204002 Sat, 21 Feb 2009 05:00:00 +0100 2204002 http://www.medworm.com/index.php?rid=2204001&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19230042%26dopt%3DAbstract Authors: Macias RI, Marin JJ, Serrano MA In adults, the hepatobiliary system, together with the kidney, constitute the main routes for the elimination of several endogenous and xenobiotic compounds into bile and urine, respectively. However, during intrauterine life the biliary route of excretion for cholephilic compounds, such as bile acids and biliary pigments, is very poor. Although very early in pregnancy the fetal liver produces bile acids, bilirubin and biliverdin, these compounds cannot be efficiently eliminated by the fetal hepatobiliary system, owing to the immaturity of the excretory machinery in the fetal liver. Therefore, the potentially harmful accumulation of cholephilic compounds in the fetus is prevented by their elimination across the placenta. Owing to the presence of... World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2204001 Sat, 21 Feb 2009 05:00:00 +0100 2204001 http://www.medworm.com/index.php?rid=2204000&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19230043%26dopt%3DAbstract CONCLUSION: Vascular and capsular invasion with superimposed spread into the adjacent pancreatic parenchyma and nearby structures in SPTs of the pancreas can be accurately revealed by MDCT preoperatively. These imaging findings are predictive of the malignant potential associated with the aggressive behavior of the tumor, even in the pathologically benign cases. PMID: 19230043 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2204000 Sat, 21 Feb 2009 05:00:00 +0100 2204000 http://www.medworm.com/index.php?rid=2203999&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19230044%26dopt%3DAbstract CONCLUSION: Progress from adhesion to detachment of EC9706 cells causes DR5 relocalization, and promotes cytoplasmic translocation of DR5 to cell surfaces via a Golgi-dependent pathway. Moreover, it might also result in DR5 aggregation to render apoptosis of detached cells. PMID: 19230044 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2203999 Sat, 21 Feb 2009 05:00:00 +0100 2203999 http://www.medworm.com/index.php?rid=2203998&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19230045%26dopt%3DAbstract CONCLUSION: These data demonstrate that the production of anti-tTG IgA is directly correlated to the production of anti-DGP IgG and IgA, whereas anti-tTG IgG is only weakly correlated. This result therefore supports the hapten-carrier theory that in well-established celiac patients anti-tTG IgA is produced by a set of B cells that are reacting against the complex of tTG-DGP in the absence of a tTG-specific T cell. PMID: 19230045 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2203998 Sat, 21 Feb 2009 05:00:00 +0100 2203998 http://www.medworm.com/index.php?rid=2203997&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19230046%26dopt%3DAbstract CONCLUSION: Despite the estimated two-fold reduction of HBsAg prevalence in the general population from about 18%-19% to 9.5%, Albania remains a highly endemic country (i.e. over 8% of HBsAg prevalence rate). PMID: 19230046 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2203997 Sat, 21 Feb 2009 05:00:00 +0100 2203997 http://www.medworm.com/index.php?rid=2203996&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19230047%26dopt%3DAbstract CONCLUSION: Serum biomarker tests can be used to differentiate between subjects with healthy and diseased gastric mucosa with high accuracy. PMID: 19230047 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2203996 Sat, 21 Feb 2009 05:00:00 +0100 2203996 http://www.medworm.com/index.php?rid=2203995&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19230048%26dopt%3DAbstract CONCLUSION: One- or two-week furazolidone and amoxicillin-based quadruple rescue therapy with a low dose furazolidone (100 mg bid) for the eradication of H pylori is effective. Extending the antibiotic course to 14 d could improve the eradication rates. PMID: 19230048 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2203995 Sat, 21 Feb 2009 05:00:00 +0100 2203995 http://www.medworm.com/index.php?rid=2203994&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19230049%26dopt%3DAbstract CONCLUSION: The finger print mass spectrum of saliva protein in patients with gastric cancer can be established using gastric cancer proteomics. A diagnostic model for distinguishing protein expression mass spectra of gastric cancer from non-gastric-cancer saliva can be established according to the different expression of proteins 1472.78 Da, 2936.49 Da, 6556.81 Da and 7081.17 Da. The method for early diagnosis of gastric cancer is of certain value for screening special biological markers. PMID: 19230049 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2203994 Sat, 21 Feb 2009 05:00:00 +0100 2203994 http://www.medworm.com/index.php?rid=2203993&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19230050%26dopt%3DAbstract CONCLUSION: Oxaliplatin plus capecitabine regimen is effective and tolerable in metastatic ESCC patients. The regimen has improved the survival moderately and merits further studies. PMID: 19230050 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2203993 Sat, 21 Feb 2009 05:00:00 +0100 2203993 http://www.medworm.com/index.php?rid=2203992&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19230051%26dopt%3DAbstract We present a case of a 19-year-old female who developed subacute obstruction due to giant inflammatory polyps, having undergone treatment for left-sided ulcerative colitis. This is followed by a review of the literature. PMID: 19230051 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2203992 Sat, 21 Feb 2009 05:00:00 +0100 2203992 http://www.medworm.com/index.php?rid=2203991&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19230052%26dopt%3DAbstract In this report, we present a 75-year-old woman with extensive hepatic portal and mesenteric venous gas due to colonic diverticulitis. She had a 10-year history of type II diabetes mellitus and hypertension. She was treated by sigmoid resection and Hartmann's procedure and discharged from the hospital without any complications. PMID: 19230052 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2203991 Sat, 21 Feb 2009 05:00:00 +0100 2203991 http://www.medworm.com/index.php?rid=2203990&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19230053%26dopt%3DAbstract Authors: Uzun MA, Koksal N, Kayahan M, Celik A, Kilicoglu G, Ozkara S Duodenal duplication, a rare congenital malformation, can also be observed in adulthood. Although it can be cystic or tubular, communicating or non-communicating, cystic and non-communicating forms are the most common. Several complications, such as obstruction, bleeding, perforation and pancreatitis, may result. Optimal treatment is total excision, although endoscopic procedures have also been described in appropriate cases. If total excision is not possible, subtotal excision and internal derivation can be performed. The 38-year-old woman presented here had occasional attacks of abdominal pain and obstruction, and we considered the diagnosis of duodenal duplication by abdominal computerized tomography. As we confir... World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2203990 Sat, 21 Feb 2009 05:00:00 +0100 2203990 http://www.medworm.com/index.php?rid=2203989&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19230054%26dopt%3DAbstract We describe a case of a 68-year-old female patient with DVT after gastrectomy for gastric carcinoma. The patient was treated with anticoagulants and thrombolytics and subjected to necessary laboratory monitoring. The patient recovered well after treatment and was symptom-free during a 3-mo follow-up. We conclude that correct diagnosis and treatment of DVT are crucial. PMID: 19230054 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2203989 Sat, 21 Feb 2009 05:00:00 +0100 2203989 http://www.medworm.com/index.php?rid=2203988&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19230055%26dopt%3DAbstract We report a rare case of SRCC of the ampulla of Vater in a 38-year-old woman who presented with a small tumor at the Vater, discovered by the contrast-enhanced ultrasound (CEUS). Histopathological examination showed prominent signet-ring features. We also describe the imaging features of SRCC of ampulla of Vater in CEUS. PMID: 19230055 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2203988 Sat, 21 Feb 2009 05:00:00 +0100 2203988 http://www.medworm.com/index.php?rid=2120147&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19152442%26dopt%3DAbstract Authors: Drozdowski L, Thomson AB There are various hormones and growth factors which may modify the intestinal absorption of nutrients, and which might thereby be useful in a therapeutic setting, such as in persons with short bowel syndrome. In part I, we focus first on insulin-like growth factors, epidermal and transferring growth factors, thyroid hormones and glucocorticosteroids. Part II will detail the effects of glucagon-like peptide (GLP)-2 on intestinal absorption and adaptation, and the potential for an additive effect of GLP2 plus steroids. PMID: 19152442 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2120147 Thu, 22 Jan 2009 05:55:01 +0100 2120147 http://www.medworm.com/index.php?rid=2120146&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19152443%26dopt%3DAbstract Authors: Marinis A, Yiallourou A, Samanides L, Dafnios N, Anastasopoulos G, Vassiliou I, Theodosopoulos T Intussusception of the bowel is defined as the telescoping of a proximal segment of the gastrointestinal tract within the lumen of the adjacent segment. This condition is frequent in children and presents with the classic triad of cramping abdominal pain, bloody diarrhea and a palpable tender mass. However, bowel intussusception in adults is considered a rare condition, accounting for 5% of all cases of intussusceptions and almost 1%-5% of bowel obstruction. Eight to twenty percent of cases are idiopathic, without a lead point lesion. Secondary intussusception is caused by organic lesions, such as inflammatory bowel disease, postoperative adhesions, Meckel's diverticulum, benign an... World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2120146 Thu, 22 Jan 2009 05:54:57 +0100 2120146 http://www.medworm.com/index.php?rid=2120145&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19152444%26dopt%3DAbstract Authors: Dai LC Midkine (MK) is a heparin-binding growth factor with its gene first identified in embryonal carcinoma cells at early stages of retinoic acid-induced differentiation. MK is frequently and highly expressed in a variety of human carcinomas. Furthermore, the blood MK level is frequently elevated with advance of human carcinomas, decreased after surgical removal of the tumors. Thus, it is expected to become a promising marker for evaluating the progress of carcinomas. There is mounting evidence that MK plays a significant role in carcinogenesis-related activities, such as proliferation, migration, anti-apoptosis, mitogenesis, transforming, and angiogenesis. In addition, siRNA and anti-sense oligonucleotides for MK have yielded great effects in anti-tumor activities. Therefor... World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2120145 Thu, 22 Jan 2009 05:54:51 +0100 2120145 http://www.medworm.com/index.php?rid=2120144&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19152445%26dopt%3DAbstract Authors: Mendoza JL, Lana R, Diaz-Rubio M The hypothesis postulating that Mycobacterium avium paratuberculosis (MAP) is the cause of Crohn's disease (CD) has been circulating for many years. Advances in molecular techniques, such as polymerase chain reaction and culture methods, have enabled researchers to demonstrate that there is an association between MAP and CD. Recently, genome-wide association studies have identified novel susceptibility genes for CD, which are critical for generation of an adaptive immune response that is protective against intracellular pathogens, including M. tuberculosis infection. However, the role of MAP as a cause of CD suffered a setback with the report that administration of antimycobacterial therapy failed to lead to a sustained response in CD patients.... World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2120144 Thu, 22 Jan 2009 05:54:47 +0100 2120144 http://www.medworm.com/index.php?rid=2120143&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19152446%26dopt%3DAbstract Authors: Barcena Marugan R, Garcia Garzon S Hepatitis B virus (HBV) infection is a global public health problem that concerns 350 million people worldwide. Individuals with chronic hepatitis B (CHB) are at increased risk of developing liver cirrhosis, hepatic de-compensation and hepatocellular carcinoma. To maintain undetectable viral load reduces chronic infection complications. There is no treatment that eradicates HBV infection. Current drugs are expensive, are associated with adverse events, and are of limited efficacy. Current guidelines try to standardize the clinical practice. Nevertheless, controversy remains about management of asymptomatic patients with CHB who are hepatitis B e antigen (HBeAg)-positive with normal alanine aminotransferase, and what is the cut-off value of vi... World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2120143 Thu, 22 Jan 2009 05:54:43 +0100 2120143 http://www.medworm.com/index.php?rid=2120142&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19152447%26dopt%3DAbstract CONCLUSION: pSUPER-shRNA/mdr1 vector system allows simple, stable and durable nonviral knockdown of P-gp by RNAi in malignant cells and animals to restore their sensitivity to adriamycin. PMID: 19152447 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2120142 Thu, 22 Jan 2009 05:54:38 +0100 2120142 http://www.medworm.com/index.php?rid=2120141&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19152448%26dopt%3DAbstract CONCLUSION: Activation of PPARgamma inhibits the growth of pancreatic carcinoma both in vitro and in vivo. Suppression of tumor angiogenesis by down-regulating the expression of VEGF may be one of the mechanisms by which PPARgamma activation inhibits the growth of pancreatic carcinoma. PMID: 19152448 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2120141 Thu, 22 Jan 2009 05:54:34 +0100 2120141 http://www.medworm.com/index.php?rid=2120140&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19152449%26dopt%3DAbstract CONCLUSION: Both regimens were well tolerated and offered effective tumor growth control in this outpatient setting. Severe gastrointestinal toxicities and thromboembolic events were rare and if observed were never fatal. PMID: 19152449 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2120140 Thu, 22 Jan 2009 05:54:29 +0100 2120140 http://www.medworm.com/index.php?rid=2120139&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19152450%26dopt%3DAbstract CONCLUSION: Beside nonsteroidal anti-inflammatory steroid drug use, antihypertensive medication and concomitant arteriosclerotic diseases are risk factors for colonic diverticular hemorrhage. Our results support the hypothesis of an altered arteriosclerotic vessel as the source of bleeding. PMID: 19152450 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2120139 Thu, 22 Jan 2009 05:54:24 +0100 2120139 http://www.medworm.com/index.php?rid=2120138&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19152451%26dopt%3DAbstract CONCLUSION: These data may indicate that hepatitis C virus infection is a risk factor for insulin resistance. PMID: 19152451 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2120138 Thu, 22 Jan 2009 05:54:20 +0100 2120138 http://www.medworm.com/index.php?rid=2120137&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19152452%26dopt%3DAbstract CONCLUSION: Preoperative immunonutrition provided a significant increase in prealbumin levels, while it did not significantly alter T lymphocyte subpopulation counts, the rate of postoperative complications and the duration of hospital stay. PMID: 19152452 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2120137 Thu, 22 Jan 2009 05:54:12 +0100 2120137 http://www.medworm.com/index.php?rid=2120136&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19152453%26dopt%3DAbstract CONCLUSION: The prevalence of NAFLD in Brazilian adolescents was low. The ethnicity may have influence this frequency in the population studied, which had a large proportion of African descendents. PMID: 19152453 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2120136 Thu, 22 Jan 2009 05:53:58 +0100 2120136 http://www.medworm.com/index.php?rid=2120135&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19152454%26dopt%3DAbstract CONCLUSION: A significant difference was observed in IHNC of infectious etiology, in which erythropoiesis was more severe than that in genetic-endocrine-metabolic and idiopathic etiologies, whereas there were no significant differences among cholestasis, eosinophilia, giant cells, siderosis, portal fibrosis, and the presence of a septum. PMID: 19152454 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2120135 Thu, 22 Jan 2009 05:53:51 +0100 2120135 http://www.medworm.com/index.php?rid=2120134&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19152455%26dopt%3DAbstract CONCLUSION: Association between higher score of H pylori in histology and a positive stool-PCR make it a very useful test for detection of H pylori active infection in children. We also suggest that a simple stool-PCR method can be a useful test for detection of H pylori virulence genes in stool. PMID: 19152455 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2120134 Thu, 22 Jan 2009 05:53:42 +0100 2120134 http://www.medworm.com/index.php?rid=2120133&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19152456%26dopt%3DAbstract CONCLUSION: Macroscopic findings are of value in differentiation between high grade intraepithelial neoplasia and superficial gastric cancer. This may simplify patient work-up and save costs for patients and healthcare system. PMID: 19152456 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2120133 Thu, 22 Jan 2009 05:53:39 +0100 2120133 http://www.medworm.com/index.php?rid=2120132&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19152457%26dopt%3DAbstract CONCLUSION: The majority of patients with esophageal carcinoma can tolerate fast track surgery. Patients younger than 65 or who have no preoperative diseases have the best results. Median length of hospital stay has been reduced to 7 d. PMID: 19152457 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2120132 Thu, 22 Jan 2009 05:53:36 +0100 2120132 http://www.medworm.com/index.php?rid=2120131&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19152458%26dopt%3DAbstract Authors: Ahmed K, Darakhshan A, Au E, Khamashta MA, Katsoulis IE The antiphospholipid syndrome (APS) is a multi-systemic disease being characterized by the presence of antiphospholipid antibodies that involves both arterial and venous systems resulting in arterial or venous thrombosis, fetal loss, thrombocytopenia, leg ulcers, livedo reticularis, chorea, and migraine. We document a previously unreported case of a 37-year-old female in whom APS was first manifested by infarction and cecal perforation following cesarean section. At laparotomy the underlying cause of colonic perforation was not clear and after resection of the affected bowel an ileo-colostomy was performed. The diagnosis of APS was established during post-operative hospital stay and the patient was commenced on warfarin. ... World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2120131 Thu, 22 Jan 2009 05:53:31 +0100 2120131 http://www.medworm.com/index.php?rid=2120130&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19152459%26dopt%3DAbstract Authors: Kapoor S The role of nm23H1 genetic instability is not limited to gastrointestinal malignancies. A similar close relationship exists between nm23H1 genetic instability and other non gastrointestinal systemic malignancies. For instance, in oral malignant melanomas with lymphoid metastasis, the nm23H1 expression is significantly lower in contrast to tumors with no lymphoid metastasis. Similarly, increased metastasis is seen in non small cell lung cancers following down regulation of nm23H1 in conjunction with KAI-1 down regulation. There is an inverse relationship between tumor stage and metastasis and nm23H1 expression in individuals with prostate carcinomas and a similar relationship exists between microsatellite instability of the nm23H1 gene and ovarian carcinogenesis. For i... World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2120130 Thu, 22 Jan 2009 05:53:28 +0100 2120130 http://www.medworm.com/index.php?rid=2072392&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19115463%26dopt%3DAbstract Authors: Burkitt MD, Varro A, Pritchard DM In addition to regulating acid secretion, the gastric antral hormone gastrin regulates several important cellular processes in the gastric epithelium including proliferation, apoptosis, migration, invasion, tissue remodelling and angiogenesis. Elevated serum concentrations of this hormone are caused by many conditions, particularly hypochlorhydria (as a result of autoimmune or Helicobacter pylori (H pylori)-induced chronic atrophic gastritis or acid suppressing drugs) and gastrin producing tumors (gastrinomas). There is now accumulating evidence that altered local and plasma concentrations of gastrin may play a role during the development of various gastric tumors. In the absence of H pylori infection, marked hypergastrinemia frequently result... World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2072392 Sat, 03 Jan 2009 06:01:43 +0100 2072392 http://www.medworm.com/index.php?rid=2072391&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19115464%26dopt%3DAbstract Authors: Gupte AR, Draganov PV Eosinophilic esophagitis is increasingly recognized in adults. The diagnosis is based on the presence of both typical symptoms and pathologic findings on esophageal biopsy. Patients usually present with dysphagia, food impaction and/or reflux-like symptoms, and biopsy of the esophagus shows more than 15 eosinophils per high-power field. In addition, it is essential to exclude the presence of known causes of tissue eosinophilia such as gastroesophageal reflux disease, infections, malignancy, collagen vascular diseases, hypersensitivity, and inflammatory bowel disease. There are no standardized protocols for the therapy of eosinophilic esophagitis. A variety of therapeutic approaches including acid suppression, dietary modifications, topical corticosteroids... World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2072391 Sat, 03 Jan 2009 06:01:32 +0100 2072391 http://www.medworm.com/index.php?rid=2072390&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19115465%26dopt%3DAbstract Authors: Waseem S, Moshiree B, Draganov PV Gastroparesis refers to abnormal gastric motility characterized by delayed gastric emptying in the absence of mechanical obstruction. The most common etiologies include diabetes, post-surgical and idiopathic. The most common symptoms are nausea, vomiting and epigastric pain. Gastroparesis is estimated to affect 4% of the population and symptomatology may range from little effect on daily activity to severe disability and frequent hospitalizations. The gold standard of diagnosis is solid meal gastric scintigraphy. Treatment is multimodal and includes dietary modification, prokinetic and anti-emetic medications, and surgical interventions. New advances in drug therapy, and gastric electrical stimulation techniques have been introduced and might ... World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2072390 Sat, 03 Jan 2009 06:01:22 +0100 2072390 http://www.medworm.com/index.php?rid=2072389&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19115466%26dopt%3DAbstract Authors: Habashi S, Draganov PV Pancreatic pseudocysts are complications of acute or chronic pancreatitis. Initial diagnosis is accomplished most often by cross-sectional imaging. Endoscopic ultrasound with fine needle aspiration has become the preferred test to help distinguish pseudocyst from other cystic lesions of the pancreas. Most pseudocysts resolve spontaneously with supportive care. The size of the pseudocyst and the length of time the cyst has been present are poor predictors for the potential of pseudocyst resolution or complications, but in general, larger cysts are more likely to be symptomatic or cause complications. The main two indications for some type of invasive drainage procedure are persistent patient symptoms or the presence of complications (infection, gastric ou... World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2072389 Sat, 03 Jan 2009 06:01:11 +0100 2072389 http://www.medworm.com/index.php?rid=2072388&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19115467%26dopt%3DAbstract Authors: Hutchins GF, Draganov PV Cystic neoplasms of the pancreas are increasingly recognized due to the expanding use and improved sensitivity of cross-sectional abdominal imaging. Major advances in the last decade have led to an improved understanding of the various types of cystic lesions and their biologic behavior. Despite significant improvements in imaging technology and the advent of endoscopic-ultrasound (EUS)-guided fine-needle aspiration, the diagnosis and management of pancreatic cystic lesions remains a significant clinical challenge. The first diagnostic step is to differentiate between pancreatic pseudocyst and cystic neoplasm. If a pseudocyst has been effectively excluded, the cornerstone issue is then to determine the malignant potential of the pancreatic cystic neopl... World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2072388 Sat, 03 Jan 2009 06:01:01 +0100 2072388 http://www.medworm.com/index.php?rid=2072387&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19115468%26dopt%3DAbstract Authors: Reddy SC, Draganov PV Guidewires are routinely used at the time of endoscopic retrograde cholangiopancreatography (ERCP) to gain and maintain access to the desired duct and aid in the advancement of various devices. Limitations of the traditional long-wire systems have led to the introduction of three proprietary short-wire systems. These systems differ in many respects but share two main principles: They lock a shorter wire in position to allow advancement or removal of various devices without displacement of the wire and they all allow for physician control of the wire. In this comprehensive review, we describe the key features of the three currently available short-wire systems: RX, Fusion and V systems. We also focus on the potential benefits and drawbacks that accompany t... World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2072387 Sat, 03 Jan 2009 06:00:50 +0100 2072387 http://www.medworm.com/index.php?rid=2072386&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19115469%26dopt%3DAbstract Authors: Ahmadi A, Polyak S, Draganov PV Patients with inflammatory bowel disease (IBD) are at increased risk for colorectal cancer (CRC). Risk factors for the development of CRC in the setting of IBD include disease duration, anatomic extent of disease, age at time of diagnosis, severity of inflammation, family history of colon cancer, and concomitant primary sclerosing cholangitis. The current surveillance strategy of surveillance colonoscopy with multiple random biopsies most likely reduces morbidity and mortality associated with IBD-related CRC. Unfortunately, surveillance colonoscopy also has severe limitations including high cost, sampling error at time of biopsy, and interobserver disagreement in histologically grading dysplasia. Furthermore, once dysplasia is detected there is ... World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2072386 Sat, 03 Jan 2009 06:00:43 +0100 2072386 http://www.medworm.com/index.php?rid=2072385&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19115470%26dopt%3DAbstract Authors: Senousy BE, Draganov PV Some patients with ascites due to liver cirrhosis become no longer responsive to diuretics. Once other causes of ascites such as portal vein thrombosis, malignancy or infection and non-compliance with medications and low sodium diet have been excluded, the diagnosis of refractory ascites can be made based on strict criteria. Patients with refractory ascites have very poor prognosis and therefore referral for consideration for liver transplantation should be initiated. Search for reversible components of the underlying liver pathology should be undertaken and targeted therapy, when available, should be considered. Currently, serial large volume paracentesis (LVP) and transjugular intrahepatic portasystemic stent-shunt (TIPS) are the two mainstay treatmen... World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2072385 Sat, 03 Jan 2009 06:00:36 +0100 2072385 http://www.medworm.com/index.php?rid=2072384&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19115471%26dopt%3DAbstract Authors: Mai V, Draganov PV The complex gut microbial flora harbored by individuals (microbiota) has long been proposed to contribute to intestinal health as well as disease. Pre- and probiotic products aimed at improving health by modifying microbiota composition have already become widely available and acceptance of these products appears to be on the rise. However, although required for the development of effective microbiota based interventions, our basic understanding of microbiota variation on a population level and its dynamics within individuals is still rudimentary. Powerful new parallel sequence technologies combined with other efficient molecular microbiota analysis methods now allow for comprehensive analysis of microbiota composition in large human populations. Recent find... World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2072384 Sat, 03 Jan 2009 06:00:26 +0100 2072384 http://www.medworm.com/index.php?rid=2072383&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19115472%26dopt%3DAbstract CONCLUSION: Infection rate of clonorchiasis was still high in patients with gastrointestinal diseases in Korea, and has not decreased very much during the last two decades. Cholangiocarcinoma was related to clonorchiasis, which suggested an etiological role for the parasite. PMID: 19115472 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2072383 Sat, 03 Jan 2009 06:00:03 +0100 2072383 http://www.medworm.com/index.php?rid=2072382&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19115473%26dopt%3DAbstract CONCLUSION: Treatment with c-myc shRNA-3 can control CPC and reduce the lithogenic potentiality of CPC. PMID: 19115473 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2072382 Sat, 03 Jan 2009 05:59:57 +0100 2072382 http://www.medworm.com/index.php?rid=2072381&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19115474%26dopt%3DAbstract CONCLUSION: This study reflects the need of the Kuwaiti population for an HAV vaccine. PMID: 19115474 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2072381 Sat, 03 Jan 2009 05:59:52 +0100 2072381 http://www.medworm.com/index.php?rid=2072380&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19115475%26dopt%3DAbstract CONCLUSION: The present study confirms the presence of iron overload in alcoholics, which was more severe in the subset of subjects with liver disease, in parallel with an increased frequency of H63D HFE mutation. PMID: 19115475 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2072380 Sat, 03 Jan 2009 05:59:36 +0100 2072380 http://www.medworm.com/index.php?rid=2072379&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19115476%26dopt%3DAbstract CONCLUSION: Despite being active, ABZ metabolites did not provide a marked advantage over 20% hypertonic saline. According to these results, we think creating a newly improved and more active preparation is necessary for hydatid cyst treatment. PMID: 19115476 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2072379 Sat, 03 Jan 2009 05:59:22 +0100 2072379 http://www.medworm.com/index.php?rid=2072378&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19115477%26dopt%3DAbstract This report is followed by a comprehensive review of the literature. PMID: 19115477 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2072378 Sat, 03 Jan 2009 05:59:16 +0100 2072378 http://www.medworm.com/index.php?rid=2072377&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19115478%26dopt%3DAbstract In conclusion, we think that the BDL model is not suitable for the study of the natural history of HRS, but the chronic BDL model might be valid for the study of established HRS and its potential therapies. PMID: 19115478 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2072377 Sat, 03 Jan 2009 05:58:50 +0100 2072377 http://www.medworm.com/index.php?rid=2045185&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19084927%26dopt%3DAbstract Authors: Larrubia JR, Benito-Martinez S, Calvino M, Sanz-de-Villalobos E, Parra-Cid T Chemokines produced in the liver during hepatitis C virus (HCV) infection induce migration of activated T cells from the periphery to infected parenchyma. The milieu of chemokines secreted by infected hepatocytes is predominantly associated with the T-helper cell/Tc1 T cell (Th1/Tc1) response. These chemokines consist of CCL3 (macrophage inflammatory protein-1alpha; MIP-1alpha), CCL4 (MIP-1beta), CCL5 (regulated on activation normal T cell expressed and secreted; RANTES), CXCL10 (interferon-gamma-inducible protein-10; IP-10), CXCL11 (interferon-inducible T-cell alpha chemoattractant; I-TAC), and CXCL9 (monokine induced by interferon gamma; Mig) and they recruit T cells expressing either CCR5 or CXCR3 ... World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2045185 Thu, 18 Dec 2008 06:08:51 +0100 2045185 http://www.medworm.com/index.php?rid=2045184&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19084928%26dopt%3DAbstract Authors: Freeman HJ The intestinal epithelial lining plays a central role in the digestion and absorption of nutrients, but exists in a harsh luminal environment that necessitates continual renewal. This renewal process involves epithelial cell proliferation in the crypt base and later cell migration from the crypt base to the luminal surface. This process is dependent on multi-potent progenitor cells, or stem cells, located in each crypt. There are about 4 to 6 stem cells per crypt, and these stem cells are believed to generate distinct end-differentiated epithelial cell types, including absorptive cells, goblet cells, enteroendocrine cells and Paneth cells, while also maintaining their own progenitor cell state. Earlier studies suggested that intestinal stem cells were located either... World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2045184 Thu, 18 Dec 2008 06:08:47 +0100 2045184 http://www.medworm.com/index.php?rid=2045183&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19084929%26dopt%3DAbstract Authors: Soumian S, Thomas S, Mohan PP, Khan N, Khan Z, Raju T Colonic diverticulosis can either be asymptomatic or present with complications resulting in significant morbidity and mortality. A key presentation of complicated disease is abscess formation (Hinchey type II). The natural course of this is unclear and therefore treatments range from conservative approach with antibiotics and percutaneous guided drainage (PCD) to surgery. There is no clear consensus on the exact management strategy. A Medline based literature search specifically looking at studies dealing with Hinchey type II diverticulitis and its management was carried out. For comparison, five-year retrospective data of diverticular abscesses from our institution was collected and the outcome analysed. Various studies h... World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2045183 Thu, 18 Dec 2008 06:08:43 +0100 2045183 http://www.medworm.com/index.php?rid=2045182&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19084930%26dopt%3DAbstract This article provides an up to date overview of the role of laser ablation in the local treatment of HCC. General principles, technique, image guidance and patient selection are discussed. A review of published data on treatment efficacy, long term outcome and complication rates of laser ablation is included and comparison with RFA made. The role of laser ablation in combination with transcatheter arterial chemoembolisation is also discussed. PMID: 19084930 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2045182 Thu, 18 Dec 2008 06:08:39 +0100 2045182 http://www.medworm.com/index.php?rid=2045181&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19084931%26dopt%3DAbstract CONCLUSION: GABA and GABRA3 play important roles in HCC development and progression and can be a promising molecular target for the development of new diagnostic and therapeutic strategies for HCC. PMID: 19084931 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2045181 Thu, 18 Dec 2008 06:08:31 +0100 2045181 http://www.medworm.com/index.php?rid=2045180&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19084932%26dopt%3DAbstract CONCLUSION: CE-US revealed that the change in intratumor blood flow correlated with both serum CA19-9 level and outcome. Patients with serum CA19-9 that decreased to less than half the baseline level, and patients with an abundant intratumor blood flow, had a significantly better outcome. Thus, CE-US is potentially useful for evaluating treatment efficacy and outcome in the early stages of pancreatic cancer chemotherapy. PMID: 19084932 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2045180 Thu, 18 Dec 2008 06:08:28 +0100 2045180 http://www.medworm.com/index.php?rid=2045179&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19084933%26dopt%3DAbstract CONCLUSION: Metformin significantly inhibits cell proliferation and apoptosis in all pancreatic cell lines. And the metformin-induced apoptosis is associated with PARP cleavage, activation of caspase-3, -8, and -9 in a time- and dose-dependent manner. Hence, both caspase-8 and -9-initiated apoptotic signaling pathways contribute to metformin-induced apoptosis in pancreatic cell lines. PMID: 19084933 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2045179 Thu, 18 Dec 2008 06:08:24 +0100 2045179 http://www.medworm.com/index.php?rid=2045178&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19084934%26dopt%3DAbstract CONCLUSION: Over-expression of the Tp53, CCND1, and C-myc genes appears to play a role in development of human cancer by regulating the expression of mRNA. Tp53, CCND1 and C-myc genes are significantly correlated with the development of different carcinomas. PMID: 19084934 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2045178 Thu, 18 Dec 2008 06:08:20 +0100 2045178 http://www.medworm.com/index.php?rid=2045177&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19084935%26dopt%3DAbstract CONCLUSION: There is only a tendency that Vitamin E may promote HBeAg seroconversion. Therefore larger studies are needed to clarify the role of antioxidants in the therapy of chronic hepatitis B. PMID: 19084935 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2045177 Thu, 18 Dec 2008 06:08:16 +0100 2045177 http://www.medworm.com/index.php?rid=2045176&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19084936%26dopt%3DAbstract CONCLUSION: The increase of the arginine/ADMA ratio after TIPS placement suggests an increase in intracellular NO bioavailability. In addition, this study suggests that TIPS placement does not alter dimethylarginine dimethylaminohydrolase (DDAH) activity and confirms the major role of the liver as an ADMA clearing organ. PMID: 19084936 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2045176 Thu, 18 Dec 2008 06:08:12 +0100 2045176 http://www.medworm.com/index.php?rid=2045175&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19084937%26dopt%3DAbstract CONCLUSION: Our results show that a 4-wk course of peg-IFN-alpha2a monotherapy can achieve a high SVR rate in "IFN-sensitive" patients, without negatively affecting outcome. PMID: 19084937 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2045175 Thu, 18 Dec 2008 06:08:08 +0100 2045175 http://www.medworm.com/index.php?rid=2045174&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19084938%26dopt%3DAbstract CONCLUSION: Peg-IFNalpha-2b plus RBV combination therapy demonstrated good tolerability in Japanese patients with CHC and resulted in a SVR rate of 44.3%. Treatment of elderly female patients is still challenging and maintenance of adherence to peg-IFNalpha-2b is important in improving the SVR rate. PMID: 19084938 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2045174 Thu, 18 Dec 2008 06:08:02 +0100 2045174 http://www.medworm.com/index.php?rid=2045173&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19084939%26dopt%3DAbstract CONCLUSION: HBV genotype D appears to be the only circulating type in Jordanian patients. The YMDD mutations were detected in 31% of lamivudine-treated cases with similar patterns to those found in the literature. We also found a relatively low prevalence of HBeAg expression among examined cases (17%). Awareness of these serologic, genotypic and resistance patterns might help in the formulation of management plans and for predicting clinical outcomes. Further larger scale studies are needed to confirm our results and to examine possible associations among clinical, serologic, and genetic patterns of HBV infections in Jordan. PMID: 19084939 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2045173 Thu, 18 Dec 2008 06:07:58 +0100 2045173 http://www.medworm.com/index.php?rid=2045172&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19084940%26dopt%3DAbstract CONCLUSION: Tuberculous peritonitis has to be clinically suspected in all patients with slowly progressive abdominal distension, particularly when it is accompanied by fever and pain. Laparoscopy and peritoneal biopsy are still the most reliable, quick and safe methods for the diagnosis of tuberculous peritonitis. PMID: 19084940 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2045172 Thu, 18 Dec 2008 06:07:55 +0100 2045172 http://www.medworm.com/index.php?rid=2045171&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19084941%26dopt%3DAbstract CONCLUSION: RGZ treatment can ameliorate increased hepatic IL-18 production and histological changes in liver of NAFLD rats. The beneficial effects of RGZ on NAFLD may be partly due to its inhibitory effect on hepatic IL-18 production. PMID: 19084941 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2045171 Thu, 18 Dec 2008 06:07:48 +0100 2045171 http://www.medworm.com/index.php?rid=2045170&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19084942%26dopt%3DAbstract CONCLUSION: Hepatectomy for benign hepatic lesions can be performed safely with a low morbidity and mortality, provided that it is carried out with optimized perioperative management and an innovative surgical technique. PMID: 19084942 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2045170 Thu, 18 Dec 2008 06:07:43 +0100 2045170 http://www.medworm.com/index.php?rid=2045169&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19084943%26dopt%3DAbstract Authors: Ikuta S, Aihara T, Yasui C, Iida H, Yanagi H, Mitsunobu M, Kakuno A, Yamanaka N Mucinous cystic neoplasms (MCNs) of the pancreas occur mostly in females and are potentially sex hormone-sensitive. However, a MCN occurring during pregnancy is quite rare. A 30-year-old woman in the tenth week of pregnancy was referred to us because of a rapid increase in left hypochondrial distending pain. On ultrasound, the patient had a large intra-abdominal cystic lesion. She was thereafter diagnosed with missed abortion and a computed tomography scan showed that the lesion was a cystic tumor 18 cm in diameter originating from the pancreatic tail. The patient subsequently underwent tumor resection with distal pancreatectomy, sparing the spleen. Histopathological analysis of the specimen reveal... World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2045169 Thu, 18 Dec 2008 06:07:38 +0100 2045169 http://www.medworm.com/index.php?rid=2045168&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19084944%26dopt%3DAbstract Authors: Terada T The author reports a very rare case of sporadic primary multiple extragastrointestinal stromal tumors (EGISTs) of the omentum associated with different mutations of the exon 11 of the c-kit gene in a 75-year-old man with gastric cancer. During an operation for the cancer, two solid tumors (10 mm and 8 mm) were found in the omentum. Both tumors consisted of cellular spindle cells. Mitotic figures were two and three per 50 high power fields. The tumor cells were positive for KIT, CD34 and vimentin, but negative for desmin, S100 protein, alpha-smooth muscle actin and p53 protein. Ki67 labeling was 2% and 3%. The larger EGIST showed a deletion of codons 552-558 of exon 11 of the c-kit gene, while the smaller EGIST had a point mutation at codon 559 (GTT-->GAT) in exon 1... World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2045168 Thu, 18 Dec 2008 06:07:35 +0100 2045168 http://www.medworm.com/index.php?rid=2045167&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19084945%26dopt%3DAbstract We present intraoperative pulmonary hypertension in a 41-year-old male patient with hepatic cirrhosis. Since this patient had no preoperation laboratory data supporting the diagnosises of pulmonary hypertension and was asymptomatic for a number of years, it was necessary to send him to the intensive care unit after operation. Further study should be focued on the diagnosis and treatment of pulmonary arterial hypertension in order to reduce its mortality. PMID: 19084945 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2045167 Thu, 18 Dec 2008 06:07:31 +0100 2045167 http://www.medworm.com/index.php?rid=2045166&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19084946%26dopt%3DAbstract Authors: Xia D, He HY, Xu L, Quan Y, Zuo HQ, Yan LN, Li B, Zeng Y, Pan GD The safety and feasibility of pregnancy following liver transplantation (LT) have been accredited in a series of LT center. The first case in mainland China is reported. The follow-up data of a 22-year-old pregnant patient with end-stage liver disease undergone orthotopic liver transplantation were analyzed retrospectively. After surgery, the patient was uneventfully recovered and became pregnant 33 mo after LT. The patient was closely monitored and treated with a standard and individualized triple-drug immunosuppressive therapy throughout her pregnancy. Caesarean section was performed in March 18, 2004, and a health live-born infant was delivered. After the delivery, a 4-year follow-up period indicated that the ... World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2045166 Thu, 18 Dec 2008 06:07:28 +0100 2045166 http://www.medworm.com/index.php?rid=2045165&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19084947%26dopt%3DAbstract Authors: Ma L, Liu YP, Geng CZ, Tian ZH, Wu GX, Wang XL The clinical characteristics of undifferentiated (embryonal) sarcoma of the liver (UESL) were investigated and the best treatment modalities were recommended. Both histology and immuno-histochemistry demonstrated the cellular features of this peculiar tumor. The tumor size was 12 cm multiply 9 cm multiply 8 cm in the right liver lobe. The patient underwent surgical resection of the tumor. The postoperative recovery was uneventful and she died eight months after diagnosis. The tumor showed mixed spindle and polygonal cells within the myxoid matrix. Some tumor cells contained eosinophilic hyaline globules that were positive for resistant diastase. Immunohistochemistry showed positive vimentin. Stellate and spindle cells were positiv... World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2045165 Thu, 18 Dec 2008 06:07:23 +0100 2045165 http://www.medworm.com/index.php?rid=2045164&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19084948%26dopt%3DAbstract Authors: Filik L, Biyikoglu I The differential diagnosis of Behcet's disease (BD) from inflammatory bowel disease (IBD) is sometimes difficult and challenging. Hereby, we suggested the utility of anti-saccharomyces cerevisiae antibody (ASCA) and anti-neutrophilic cytoplasmic antibody (p-ANCA) in the differential diagnosis of BD from IBD. PMID: 19084948 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2045164 Thu, 18 Dec 2008 06:07:20 +0100 2045164 http://www.medworm.com/index.php?rid=2045202&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19084910%26dopt%3DAbstract Authors: Hopfner M, Schuppan D, Scherubl H The limited efficacy of cytotoxic therapy for advanced biliary tract and gallbladder cancers emphasizes the need for novel and more effective medical treatment options. A better understanding of the specific biological features of these neoplasms led to the development of new targeted therapies, which take the abundant expression of several growth factors and cognate tyrosine kinase receptors into account. This review will briefly summarize the status and future perspectives of antiangiogenic and growth factor receptor-based pharmacological approaches for the treatment of biliary tract and gallbladder cancers. In view of multiple novel targeted approaches, the rationale for innovative therapies, such as combinations of growth factor (receptor)... World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2045202 Sun, 14 Dec 2008 05:00:00 +0100 2045202 http://www.medworm.com/index.php?rid=2045201&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19084911%26dopt%3DAbstract Authors: Sirica AE Aberrant expression and signaling of epidermal growth factor receptor (ErbB) family receptor tyrosine kinases, most notably that of ErbB2 and ErbB1, have been implicated in the molecular pathogenesis of intrahepatic cholangiocarcinoma. Constitutive overexpression of ErbB2 and/or ErbB1 in malignant cholangiocytes has raised interest in the possibility that agents which selectively target these receptors could potentially be effective in cholangiocarcinoma therapy. However, current experience with such ErbB-directed therapies have at best produced only modest responses in patients with biliary tract cancers. This review provides a comprehensive and critical analysis of both preclinical and clinical studies aimed at assessing the role of altered ErbB2 and/or ErbB1 expre... World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2045201 Sun, 14 Dec 2008 05:00:00 +0100 2045201 http://www.medworm.com/index.php?rid=2045200&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19084912%26dopt%3DAbstract Authors: Lehmann GL, Larocca MC, Soria LR, Marinelli RA This review focuses on current knowledge on hepatocyte aquaporins (AQPs) and their significance in bile formation and cholestasis. Canalicular bile secretion results from a combined interaction of several solute transporters and AQP water channels that facilitate water flow in response to the osmotic gradients created. During choleresis, hepatocytes rapidly increase their canalicular membrane water permeability by modulating the abundance of AQP8. The question was raised as to whether the opposite process, i.e. a decreased canalicular AQP8 expression would contribute to the development of cholestasis. Studies in several experimental models of cholestasis, such as extrahepatic obstructive cholestasis, estrogen-induced cholestasis, ... World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2045200 Sun, 14 Dec 2008 05:00:00 +0100 2045200 http://www.medworm.com/index.php?rid=2045199&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19084913%26dopt%3DAbstract Authors: Mottino AD, Catania VA The canalicular membrane represents the excretory pole of hepatocytes. Bile is an important route of elimination of potentially toxic endo- and xenobiotics (including drugs and toxins), mediated by the major canalicular transporters: multidrug resistance protein 1 (MDR1, ABCB1), also known as P-glycoprotein, multidrug resistance-associated protein 2 (MRP2, ABCC2), and the breast cancer resistance protein (BCRP, ABCG2). Their activities depend on regulation of expression and proper localization at the canalicular membrane, as regulated by transcriptional and post-transcriptional events, respectively. At transcriptional level, specific nuclear receptors (NR)s modulated by ligands, co-activators and co-repressors, mediate the physiological requirements of t... World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2045199 Sun, 14 Dec 2008 05:00:00 +0100 2045199 http://www.medworm.com/index.php?rid=2045198&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19084914%26dopt%3DAbstract CONCLUSION: Colorectal irradiation induces Th2 polarization, defective IL-10/STAT3 pathway activation and SOCS3 overexpression. These changes, in turn, maintain a immunological imbalance that persists in the long term. PMID: 19084914 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2045198 Sun, 14 Dec 2008 05:00:00 +0100 2045198 http://www.medworm.com/index.php?rid=2045197&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19084915%26dopt%3DAbstract CONCLUSION: This MC classification seems to be easily explainable and learnable as shown by excellent intra- and inter-observer agreement, and improved agreement with reference. A web system such as the one used in this study may be useful for endoscopic or other image based diagnostic procedures with respect to definition, education and dissemination. PMID: 19084915 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2045197 Sun, 14 Dec 2008 05:00:00 +0100 2045197 http://www.medworm.com/index.php?rid=2045196&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19084916%26dopt%3DAbstract CONCLUSION: The molecular events involved in liver regeneration are significantly influenced by the extent of resection as SH leads to suppression and delay of liver regeneration compared to PH, which is associated with delayed activation of NF-kappaB and suppression of proregenerative cytokines. PMID: 19084916 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2045196 Sun, 14 Dec 2008 05:00:00 +0100 2045196 http://www.medworm.com/index.php?rid=2045195&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19084917%26dopt%3DAbstract CONCLUSION: These results suggest that resveratrol has protective effects against hepatic I/R injury, and is a potential therapeutic drug for ischemia reperfusion-related liver injury. PMID: 19084917 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2045195 Sun, 14 Dec 2008 05:00:00 +0100 2045195 http://www.medworm.com/index.php?rid=2045194&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19084918%26dopt%3DAbstract CONCLUSION: This study provides identification of HPV infection in almost 80% of ESP using either ACISH or PCR; overall, all of these lesions show low expression of cell-cycle markers. We suggest ACISH as an alternative diagnostic tool for HPV detection in ESP. PMID: 19084918 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2045194 Sun, 14 Dec 2008 05:00:00 +0100 2045194 http://www.medworm.com/index.php?rid=2045193&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19084919%26dopt%3DAbstract CONCLUSION: We report for the first time the immunolocalization of NPC in the pancreas of mice of different ages (3 d to 8 wk) with reference to insulin and glucagon positive cells. The heterogeneous localization of the NPC observed may be of functional and developmental significance and suggest(s) that mice pancreatic tissue can be a potential source of progenitor cells. NPC from the pancreas can be isolated, proliferated and programmed to differentiate into insulin secreting cells under the appropriate microenvironment. PMID: 19084919 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2045193 Sun, 14 Dec 2008 05:00:00 +0100 2045193 http://www.medworm.com/index.php?rid=2045192&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19084920%26dopt%3DAbstract CONCLUSION: The APRI >= 1.5 in combination with a HA cut-off point > 300 ng/mL can detect moderate to severe fibrosis (stages 2-4) in CHB patients. PMID: 19084920 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2045192 Sun, 14 Dec 2008 05:00:00 +0100 2045192 http://www.medworm.com/index.php?rid=2045191&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19084921%26dopt%3DAbstract CONCLUSION: HM has the best efficacy in patients with recurrent achlasia who were treated with HM as first-line treatment. Future studies should focus on how to increase the success rate and decrease the complications of HM. PMID: 19084921 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2045191 Sun, 14 Dec 2008 05:00:00 +0100 2045191 http://www.medworm.com/index.php?rid=2045190&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19084922%26dopt%3DAbstract CONCLUSION: BM-derived DCs pulsed with tumor lysates can induce anti-tumor immunity specific to gastric cancer ex vivo. PMID: 19084922 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2045190 Sun, 14 Dec 2008 05:00:00 +0100 2045190 http://www.medworm.com/index.php?rid=2045189&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19084923%26dopt%3DAbstract Authors: Orenbuch-Harroch E, Levy L, Ben-Chetrit E Hepatitis B virus (HBV) infection constitutes a serious global health problem. In countries with intermediate or high endemicity for HBV, exacerbations of chronic hepatitis B may be the first presentation of HBV infection. Some of these patients may be diagnosed mistakenly as having acute hepatitis B. Accurate diagnosis in these cases is very important for deciding whether to start treatment or not, because acute hepatitis B does not require therapy, while exacerbation of chronic hepatitis may benefit from it. Clinical and routine laboratory findings cannot help distinguishing between these two conditions. Therefore, several assays have been proposed for this purpose during the last few years. The presence of high levels of anti-HBe an... World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2045189 Sun, 14 Dec 2008 05:00:00 +0100 2045189 http://www.medworm.com/index.php?rid=2045188&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19084924%26dopt%3DAbstract Authors: Sheng LM, Zhang LZ, Xu HM, Zhu Y Metastatic palatine tonsil cancer is extremely rare, with nearly 100 such tumors reported in the English literature. The prognosis of metastatic palatine tonsil cancer is poor. A 53-year-old man presented with painless left palatine tonsillar swelling and a cervical mass following right hemicolectomy for an ascending colon adenocarcinoma. Physical examination showed an ulcerated mass located on the upper pole of the left palatine tonsil. A punch biopsy was taken for histological examination which showed a moderately-differentiated adenocarcinoma. The patient was treated with palliative radiotherapy and chemotherapy. He was still alive when we wrote this paper. Our case shows that immunohistochemical diagnosis of metastatic palatine tonsil cance... World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2045188 Sun, 14 Dec 2008 05:00:00 +0100 2045188 http://www.medworm.com/index.php?rid=2045187&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19084925%26dopt%3DAbstract Authors: Kounis GN, Kouni SA, Hahalis G, Kounis NG 5-aminosalicylic acid (mesalamine) rarely induces hypersensitivity reactions. If chest pain associated with atypical electrocardiographic changes are seen during its administration, one should always bear in mind type I variant of Kounis syndrome. This variant includes patients, of any age, with normal coronary arteries, without predisposing factors for coronary artery disease, in whom the acute release of inflammatory mediators from mast cells can induce either sudden coronary artery narrowing, without increase of cardiac enzymes and troponins, or coronary artery spasm that progresses to acute myocardial infarction, with elevated cardiac enzymes and troponins. PMID: 19084925 [PubMed - in process] (Source: World Journal of Gastroen... World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2045187 Sun, 14 Dec 2008 05:00:00 +0100 2045187 http://www.medworm.com/index.php?rid=2045186&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19084926%26dopt%3DAbstract Authors: Garg P Song et al have reported a 100% success rate of acellular extracellular matrix (AEM) anal fistula plug in low fistula-in-ano. The results with this product in high fistula-in-ano are keenly awaited. PMID: 19084926 [PubMed - in process] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2045186 Sun, 14 Dec 2008 05:00:00 +0100 2045186 http://www.medworm.com/index.php?rid=2015923&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19058322%26dopt%3DAbstract Authors: Pantopoulos K Hereditary hemochromatosis (HH) is caused by chronic hyperabsorption of dietary iron. Progressive accumulation of excess iron within tissue parenchymal cells may lead to severe organ damage. The most prevalent type of HH is linked to mutations in the HFE gene, encoding an atypical major histocompatibility complex class I molecule. Shortly after its discovery in 1996, the hemochromatosis protein HFE was shown to physically interact with transferrin receptor 1 (TfR1) and impair the uptake of transferrin-bound iron in cells. However, these findings provided no clue why HFE mutations associate with systemic iron overload. It was later established that all forms of HH result from misregulation of hepcidin expression. This liver-derived circulating peptide hormone cont... World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2015923 Sun, 07 Dec 2008 05:00:00 +0100 2015923 http://www.medworm.com/index.php?rid=2015922&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19058323%26dopt%3DAbstract Authors: Papatheodoridis GV, Manolakopoulos S, Archimandritis AJ The optimal approach to the management of several marginal cases with chronic hepatitis B virus (HBV) infection is controversial. Serum HBV DNA and aminotransferase levels, and the degree of necroinflammation and fibrosis determine the therapeutic decisions. All patients with elevated aminotransferase (> twice the upper limit of normal) and serum HBV DNA above 20000 IU/mL should be treated. Liver biopsy is important for therapeutic decisions in cases with mild aminotransferase elevations and serum HBV DNA below 20000 IU/mL. Chronic HBV patients who do not receive treatment should be followed for life. There are seven agents licensed for chronic hepatitis B: standard and pegylated interferon-alpha, lamivudine, adefovir,... World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2015922 Sun, 07 Dec 2008 05:00:00 +0100 2015922 http://www.medworm.com/index.php?rid=2015921&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19058324%26dopt%3DAbstract Authors: Freeman HJ There is an increased awareness that celiac disease may occur in the elderly although presentations with either diarrhea, weight loss or both may be less common causing delays in diagnosis for prolonged periods. Higher detection rates also seem evident owing to active case screening, largely through serodiagnostic measures. In some elderly patients who are genetically predisposed, it has been hypothesized that celiac disease might be precipitated late in life by an antigen, possibly from an infectious agent. As a result, peptide mimicry or other poorly-defined mechanisms may precipitate an autoimmune gluten-dependent clinical state. Although diarrhea and weight loss occur, only isolated iron deficiency anemia may be present at the time of initial diagnosis. In addit... World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2015921 Sun, 07 Dec 2008 05:00:00 +0100 2015921 http://www.medworm.com/index.php?rid=2015920&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19058325%26dopt%3DAbstract Authors: Leenders MW, Nijkamp MW, Borel Rinkes IH Primary liver cancer remains one of the most lethal malignancies worldwide. Due to differences in prevalence of etiological factors the incidence of primary liver cancer varies among the world, with a peak in East-Asia. As this disease is still lethal in most of the cases, research has to be done to improve our understanding of the disease, offering insights for possible treatment options. For this purpose, animal models are widely used, especially mouse models. In this review, we describe the different types of mouse models used in liver cancer research, with emphasis on genetically engineered mice used in this field. We focus on hepatocellular carcinoma (HCC), as this is by far the most common type of primary liver cancer, accounting ... World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2015920 Sun, 07 Dec 2008 05:00:00 +0100 2015920 http://www.medworm.com/index.php?rid=2015919&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19058326%26dopt%3DAbstract CONCLUSION: H pylori induces no obvious damage to HGBEC. PMID: 19058326 [PubMed - as supplied by publisher] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2015919 Sun, 07 Dec 2008 05:00:00 +0100 2015919 http://www.medworm.com/index.php?rid=2015918&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19058327%26dopt%3DAbstract CONCLUSION: Though the total accuracy and specificity rates by the computer-aided screening for the enteric lesions with IPS are much lower than those by the CE readers, the computer-aided screening diagnosis can exclude a large number of the normal images and confine the enteric lesions to 5000 images on average, which can reduce the workload of the readers in the scanning of the images. This computer-aided screening technique can make a correct diagnosis as efficiently as possible in most of the patients. PMID: 19058327 [PubMed - as supplied by publisher] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2015918 Sun, 07 Dec 2008 05:00:00 +0100 2015918 http://www.medworm.com/index.php?rid=2015917&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19058328%26dopt%3DAbstract CONCLUSION: Wy14643 pretreatment exerts significant protection against hepatic I/R injury in rats. The protective effects are possibly associated with enhancement of anti-oxidant and inhibition inflammation response. PMID: 19058328 [PubMed - as supplied by publisher] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2015917 Sun, 07 Dec 2008 05:00:00 +0100 2015917 http://www.medworm.com/index.php?rid=2015916&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19058329%26dopt%3DAbstract CONCLUSION: Our modified model is a simplified method to induce cirrhosis which is rapid (6 to 9 wk), efficient and stable up to 3 mo. Using this method, "Child Pugh A" or "Child Pugh BC" cirrhotic rats were obtained. Our models of cirrhosis and hepatectomy can be used in various situations focusing on postoperative survival. PMID: 19058329 [PubMed - as supplied by publisher] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2015916 Sun, 07 Dec 2008 05:00:00 +0100 2015916 http://www.medworm.com/index.php?rid=2015915&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19058330%26dopt%3DAbstract CONCLUSION: This prospective study showed that CD has a high prevalence (1:48) in adult dyspeptic patients and suggests the routine use of duodenal biopsy in this type of patient undergoing EGD. PMID: 19058330 [PubMed - as supplied by publisher] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2015915 Sun, 07 Dec 2008 05:00:00 +0100 2015915 http://www.medworm.com/index.php?rid=2015914&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19058331%26dopt%3DAbstract CONCLUSION: Transient colonization with C. concisus was observed in mice with loss of body weight. Future studies should concentrate on the first few days after inoculation and in other strains of mice. PMID: 19058331 [PubMed - as supplied by publisher] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2015914 Sun, 07 Dec 2008 05:00:00 +0100 2015914 http://www.medworm.com/index.php?rid=2015913&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19058332%26dopt%3DAbstract CONCLUSION: Despite lower antioxidant levels there was no increase in the circulating markers of oxidative stress on the first day after major abdominal surgery. The rise in F2-isoprostane in patients receiving the antioxidant supplement may be related to the conversion of antioxidants to oxidants which raises questions on antioxidant supplementation. Module AOX restored the postoperative decrease in selenium levels. The rapid decrease in LBP levels in the antioxidant group suggests a possible protective effect on gut wall integrity. Further studies are needed on the role of oxidative stress on outcome and the use of antioxidants in patients undergoing major abdominal surgery. PMID: 19058332 [PubMed - as supplied by publisher] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2015913 Sun, 07 Dec 2008 05:00:00 +0100 2015913 http://www.medworm.com/index.php?rid=2015912&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19058333%26dopt%3DAbstract CONCLUSION: Our study demonstrated that pancreatic fistulas are related to age and a dilated pancreatic duct. The surgeon must take these risk factors into consideration when performing a pancre-aticoduodenectomy. PMID: 19058333 [PubMed - as supplied by publisher] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2015912 Sun, 07 Dec 2008 05:00:00 +0100 2015912 http://www.medworm.com/index.php?rid=2015911&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19058334%26dopt%3DAbstract CONCLUSION: For women of childbearing age with acute pain in the upper right abdomen alone or together with pain in the lower abdomen, Fitz-Hugh-Curtis syndrome should be considered during differential diagnosis. Moreover, in cases suspected to be Fitz-Hugh-Curtis syndrome, abdominal CT, rather than abdominal sonography, assists in the diagnosis. PMID: 19058334 [PubMed - as supplied by publisher] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2015911 Sun, 07 Dec 2008 05:00:00 +0100 2015911 http://www.medworm.com/index.php?rid=2015910&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19058335%26dopt%3DAbstract CONCLUSION: MCRC is associated with a non-significant decrease in median survival and TTP, particularly when mucin content is > 75% of tumor volume. However, it tends to be more poorly differentiated. A larger study matching for stage and grade is needed. PMID: 19058335 [PubMed - as supplied by publisher] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2015910 Sun, 07 Dec 2008 05:00:00 +0100 2015910 http://www.medworm.com/index.php?rid=2015909&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19058336%26dopt%3DAbstract CONCLUSION: Low consumption of green vegetables and fresh fruits, alcohol drinking, and unsafe water (shallow well, or river) and polymorphisms in MTHFR and CYP4502E1 genes are important risk factors for EC. There is a synergistic interaction among polymorphisms in MTHFR and CYP4502E1 genes and environment factors. MTHFR and CYP4502E1 genes can be used as biomarkers for prevention of EC in Kazakh, Xinjiang Uygur Autonomous Region, China. PMID: 19058336 [PubMed - as supplied by publisher] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2015909 Sun, 07 Dec 2008 05:00:00 +0100 2015909 http://www.medworm.com/index.php?rid=2015908&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19058337%26dopt%3DAbstract CONCLUSION: Chronic stress can induce mast cell proliferation, activation, and granule hyperplasia in gastric antrum. Fluoxetine counteracts such changes in the depressed rat model. PMID: 19058337 [PubMed - as supplied by publisher] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2015908 Sun, 07 Dec 2008 05:00:00 +0100 2015908 http://www.medworm.com/index.php?rid=2015907&cid=s_30379_17_f&fid=30379&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19058338%26dopt%3DAbstract We report two cases of acute hepatitis in the setting of Hydroxycut exposure and describe possible mechanisms of liver injury. We also comprehensively review and summarize the existing literature on commonly used weight loss supplements, and their individual components which have demonstrated potential for liver toxicity. An increased effort to screen for and educate patients and physicians about supplement-associated hepatotoxicity is warranted. PMID: 19058338 [PubMed - as supplied by publisher] (Source: World Journal of Gastroenterology) World Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=2015907 Sun, 07 Dec 2008 05:00:00 +0100 2015907