World Journal of Surgical Oncology via MedWorm.com

The diagnostic challenge of mediastinal sarcoidosis accompanying esophageal cancer

World Journal of Surgical Oncology — Fri, 12 Mar 2010 00:00:00 +0100

The primary staging of an oesophageal cancer can be difficult, if accompanied by sarcoidosis. In these patients endosonography, CT and PET may not be sufficient for staging purposes concerning lymph node and distant metastases. In these special cases operative biopsies of enlarged lymph nodes and unclear pulmonary nodules have to be obtained. In connection with the radiographic examinations the histopathological results of the biopsies contribute to further precise staging and help to decide on a curative versus a palliative therapy concept. (Source: World Journal of Surgical Oncology)

Pheochromocytoma associated with neurofibromatosis type 1: concepts and current trends

World Journal of Surgical Oncology — Wed, 10 Mar 2010 00:00:00 +0100

Conclusion: Nowadays in the era of laparoscopy, patients with pheochromocytoma reach the operating theatre easier than in the past. Despite, the feasibility and oncological efficacy of the laparoscopic approach to the adrenals, continued long term follow-up is needed to establish the minimally invasive technique as the preferred approach. Furthermore, these patients should be further investigated for other neoplasias and stigmata of other neurocutaneous syndromes, taking into account the association of the familial pheochromo-cytoma with other familial basis inherited diseases. (Source: World Journal of Surgical Oncology)

Surgical management of mediastinal liposarcoma extending from hypopharynx to carina: Case report

World Journal of Surgical Oncology — Tue, 02 Mar 2010 00:00:00 +0100

We describe the complete resection of a giant, well-differentiated mediastinal liposarcoma extending retropharynx to envelop the aortic arch, trachea and esophagus following preoperative radiotherapy. (Source: World Journal of Surgical Oncology)

Primary carcinoid tumor of the gallbladder: A case report and brief review of the literature

World Journal of Surgical Oncology — Tue, 23 Feb 2010 00:00:00 +0100

Conclusion: Primary carcinoid tumor of the gallbladder is uncommon. The definite diagnosis is often made on histopathological results after surgery. (Source: World Journal of Surgical Oncology)

Can primary optimal cytoreduction be predicted in advanced epithelial ovarian cancer preoperatively?

World Journal of Surgical Oncology — Fri, 19 Feb 2010 00:00:00 +0100

Conclusions: Because of small populations in our study the results are not reproducible in alternate populations. Only the patient who is most unlikely to undergo optimal cytoreduction should be offered neoadjuvant chemotherapy, unless her medical condition renders her unsuitable for primary surgery. (Source: World Journal of Surgical Oncology)

Expression of cell cycle proteins in male breast carcinoma

World Journal of Surgical Oncology — Fri, 12 Feb 2010 00:00:00 +0100

Conclusion: Aberrant cell cycle protein expression supports our view that these are important pathways involved in the etiopathogenesis of MBC. Tumors with overexpression of Cyclin D1 and c-myc had better outcomes, in contrast to tumors with overexpression of p21, p57, and PCNA with significantly worse outcomes. P27 appears to be a predictive marker for lymph nodal status. Such observation strongly suggests that dysregulation of cell cycle proteins may play a unique role in the initiation and progression of disease in male breast cancer. Such findings open up new avenues for the treatment of MBC as a suitable candidate for novel CDK-based anticancer therapies in the future. (Source: World Journal of Surgical Oncology)

Probing the link between oestrogen receptors and oesophageal cancer

World Journal of Surgical Oncology — Wed, 10 Feb 2010 00:00:00 +0100

Conclusion: We postulate that differential oestrogen receptor status may be considered a biomarker of poor clinical outcome based on tissue dedifferentiation or advanced stage of the disease. Further, if we can establish the importance of oestrogen and its receptors in the context of oesophageal cancer, then this may lead to a new future direction in the management of this malignancy. (Source: World Journal of Surgical Oncology)

Pathological complete response induced by first-line chemotherapy with single agent docetaxel in a patient with advanced non small cell lung cancer

World Journal of Surgical Oncology — Fri, 05 Feb 2010 00:00:00 +0100

Conclusion: In non-operable NSCLC patients not eligible for a platinum-based treatment, single-agent docetaxel can provide complete pathologic responses. Failure to obtain a response after the first few cycles should not automatically discourage to continue treatment. (Source: World Journal of Surgical Oncology)

Solitary adrenal metastasis from invasive ductal breast cancer: an uncommon finding

World Journal of Surgical Oncology — Thu, 28 Jan 2010 00:00:00 +0100

Conclusion: This is the first case of a patient with solitary, metachronous adrenal metastasis from IDC of the breast to be reported. For patients in this condition, complete removal of metastasized organ may translate into survival benefit. (Source: World Journal of Surgical Oncology)

Ductal carcinoma in situ and sentinel lymph node metastasis in breast cancer

World Journal of Surgical Oncology — Wed, 27 Jan 2010 00:00:00 +0100

Background: The impact of sentinel lymph node biopsy on breast cancer mimicking ductal carcinoma in situ (DCIS) is a matter of debate. Methods: We studied the rate of occurrence of sentinel lymph node metastasis in 255 breast cancer patients with pure DCIS showing no invasive components on routine pathological examination. We compared this to the rate of occurrence in 177 patients with predominant intraductal-component (IDC) breast cancers containing invasive foci equal to or less than 0.5 cm in size. Results: Most of the clinical and pathological baseline characteristics were the same between the two groups. However, peritumoral lymphatic permeation occurred less often in the pure DCIS group than in the IDC-predominant invasive-lesion group (1.2% vs. 6.8%, p=0.002). One patient (0.39%) wi...

The effect of intraoperative specimen inking on lumpectomy re-excision rates

World Journal of Surgical Oncology — Mon, 18 Jan 2010 00:00:00 +0100

Conclusions: Intraoperative inking in this practice offered a simple way to reduce re-excision rates after lumpectomy and affect an improvement in quality of patient care (Source: World Journal of Surgical Oncology)

Intramedullary non-specific inflammatory lesion of thoracic spine: A case report

World Journal of Surgical Oncology — Fri, 15 Jan 2010 00:00:00 +0100

Conclusions: Intramedullary lesions that mimick a tumor can be various and difficult to interpret. Preoperative MRI does not allow a certain diagnosis because these lesions have a very similar signal intensity pattern. Specific tests for infective pathologies are useful for diagnosis, but histological examination is essential for establishing a certain diagnosis. In our case the final histological examination and the specific tests that we performed have not cleared our doubts regarding the nature of the lesion that remains controversial. (Source: World Journal of Surgical Oncology)

Blurred vision due to choroidal metastasis as the first manifestation of lung cancer: A case report

World Journal of Surgical Oncology — Fri, 08 Jan 2010 00:00:00 +0100

Conclusion: Blurred vision due to choroidal metastasis as the primary symptom of lung cancer is very uncommon. A great index of suspicion is essential when a choroidal lesion appears. (Source: World Journal of Surgical Oncology)

A pre-operative elevated neutrophil: lymphocyte ratio does not predict survival from oesophageal cancer resection

World Journal of Surgical Oncology — Wed, 06 Jan 2010 00:00:00 +0100

Background: Elevated pre-operative neutrophil: lymphocyte ratio (NLR) has been identified as a predictor of survival in patients with hepatocellular and colorectal cancer. The aim of this study was to examine the prognostic value of an elevated preoperative NLR following resection for oesophageal cancer. Methods: Patients who underwent resection for oesophageal carcinoma from June 1997 to September 2007 were identified from a local cancer database. Data on demographics, conventional prognostic markers, laboratory analyses including blood count results, and histopathology were collected and analysed. Results: A total of 294 patients were identified with a median age at diagnosis of 65.2 (IQR 59-72) years. The median pre-operative time of blood sample collection was three days (IQR 1-8). The...

Nine years experience in surgical approach of leiomyomatosis of esophagus.

World Journal of Surgical Oncology — Wed, 23 Dec 2009 00:00:00 +0100

Conclusions: Esophageal leiomyoma is a benign tumor, which causes symptoms only if its size becomes large. Surgical enucleation is considered to be safe and effective, without complications.Key Words: Esophageal leiomyoma, surgical treatment. (Source: World Journal of Surgical Oncology)

Supracricoid partial laryngectomy with cricohyoidoepiglottopexy in patients with radiation therapy failure

World Journal of Surgical Oncology — Sat, 19 Dec 2009 00:00:00 +0100

Conclusions: In selected patient with persistence and/or recurrence after radiotherapy due to cancer of the larynx, SCPL with CHEP seems to be feasible with acceptable local control and toxicity. Complications may occur as in previously non-irradiated patients. These complications must be treated conservatively to avoid altering laryngeal function. (Source: World Journal of Surgical Oncology)

Atypical presentation of angiosarcoma of the scalp in the setting of Human Immunodeficiency Virus (HIV)

World Journal of Surgical Oncology — Fri, 18 Dec 2009 00:00:00 +0100

Conclusions: South Africa is at the epicenter of the HIV epidemic. Consequently, the management of patients in the field of oncology in our clinical practice is often burdened with malignancies manifesting with an atypical disease presentation and clinical course. (Source: World Journal of Surgical Oncology)

Gamma Knife radiosurgery for vestibular schwannoma: case report and review of the literature

World Journal of Surgical Oncology — Fri, 18 Dec 2009 00:00:00 +0100

We present a contemporary case report, describing the finding of a vestibular schwannoma in a patient who presented with dizziness and a "clicking" sensation in the ear, but no hearing deficit. Audible clicking is a symptom that, to our knowledge, has not been associated with vestibular schwannoma in the literature. We discuss the diagnosis and patient's decision-making process, which led to treatment with Gamma Knife radiosurgery. Treatment resulted in an excellent radiographic response and complete hearing preservation. This case highlights an atypical presentation of vestibular schwannoma, associated with audible "clicks" and normal hearing. We also provide a concise review of the available literature on modern vestibular schwannoma treatment, which may be useful in guiding treatment de...

Pancreatic adenocarcinoma in a patient with Situs Inversus: a case report of this rare coincidence

World Journal of Surgical Oncology — Fri, 18 Dec 2009 00:00:00 +0100

Conclusion: SI is a rare condition with concurrent pancreatic cancer being even rarer. Despite the rarity, pancreaticoduodenectomy in these patients for resectable lesions is safe as long as special consideration to the anatomy is taken. Additionally, radiographic imaging has significantly improved detection of early pancreatic cancer; however, there continues to be a need for improved detection of small neoplasms. (Source: World Journal of Surgical Oncology)

Identification of a novel germ-line mutation in the TP53 gene in a Mexican family with Li-Fraumeni syndrome

World Journal of Surgical Oncology — Thu, 17 Dec 2009 00:00:00 +0100

Conclusion: To our knowledge, this specific alteration has not been reported previously, but we believe it is the cause of the Li-Fraumeni syndrome in this family. (Source: World Journal of Surgical Oncology)

Isolated recurrence of distal adenocarcinoma of the extrahepatic bile duct on a draining sinus scar after curative resection: Case Report and review of the literature

World Journal of Surgical Oncology — Mon, 14 Dec 2009 00:00:00 +0100

Conclusions: The ideal management of these patients still remains undefined. Decisions are made based on clinical parameters from retrospective series, such as tumor grade, surgical margins or lymph node involvement. Prospective studies, that include molecular and genetic markers, are needed to improve patient selection and outcomes on this population. (Source: World Journal of Surgical Oncology)

Paraganglioma of the filum terminale: case report

World Journal of Surgical Oncology — Fri, 11 Dec 2009 00:00:00 +0100

Conclusions: This extremely rare pathology can usually be successfully treated by total surgical resection, which represents the gold standard. In the event of incomplete removal, assiduous long-term follow-up is mandatory. (Source: World Journal of Surgical Oncology)

Three synchronous primary carcinomas in a patient with HNPCC associated with a novel germline mutation in MLH1: Case report

World Journal of Surgical Oncology — Tue, 08 Dec 2009 00:00:00 +0100

Conclusions: Our case demonstrates that HNPCC patients with MLH1 mutations are also at risk for ureteral neoplasms, and therefore urological surveillance is essential. This case adds to the growing list of disease-causing MMR mutations, and contributes to the development of genotype-phenotype correlations essential for assessing individual cancer risk and tailoring of optimal surveillance strategies. Additionally, our case draws attention to limitations of the Amsterdam Criteria and the need to maintain a high index of suspicion when newly diagnosed colorectal cancer meets the Bethesda Criteria. Establishment of the diagnosis is the crucial first step in initiating appropriate surveillance for colorectal cancer and other HNPCC-associated tumors in at-risk individuals. (Source: World Journa...

A huge intraductal papillary mucinous carcinoma of the bile duct treated by right trisectionectomy with caudate lobectomy

World Journal of Surgical Oncology — Sat, 05 Dec 2009 00:00:00 +0100

Conclusion: Considering a favorable prognosis of IPMN-B compared to non-papillary biliary neoplasms, this tumor can be a good indication for aggressive surgical resection regardless of its tumor size. (Source: World Journal of Surgical Oncology)

Neuromesenchymal hamartoma of small bowel - an extremely rare entity: a case report

World Journal of Surgical Oncology — Fri, 27 Nov 2009 00:00:00 +0100

We present the case of a 60-year-old male patient admitted twice in a month with abdominal pain. On the third admission with clinical signs of acute abdomen, an exploratory laparotomy was performed. The clinical and laboratory findings that occurred after the patient's evaluation, the intraoperative findings and the pathological features of this lesion are reported. (Source: World Journal of Surgical Oncology)

Prediction of post-operative necrosis after mastectomy: A pilot study utilizing optical diffusion imaging spectroscopy

World Journal of Surgical Oncology — Wed, 25 Nov 2009 00:00:00 +0100

Conclusion: StO2 reductions may be utilized to identify impaired perfusion in mastectomy skin flaps. (Source: World Journal of Surgical Oncology)

Prediction of post-operative necrosis after mastectomy: A pilot study utilizing optical diffusion imaging spectroscopy

World Journal of Surgical Oncology — Wed, 25 Nov 2009 00:00:00 +0100

Conclusion: StO2 reductions may be utilized to identify impaired perfusion in mastectomy skin flaps. (Source: World Journal of Surgical Oncology)

Treatment of pathologic spinal fractures with combined radiofrequency ablation and balloon kyphoplasty

World Journal of Surgical Oncology — Mon, 16 Nov 2009 00:00:00 +0100

Conclusion: In our experience the treatment of pathologic spinal fractures with combined radiofrequency ablation and balloon kyphoplasty is safe and effective for immediate pain relief in painful spinal lesions in neurologically intact patients. (Source: World Journal of Surgical Oncology)

P38 MAP Kinase inhibition promotes primary tumour growth via VEGF independent mechanism

World Journal of Surgical Oncology — Sun, 15 Nov 2009 00:00:00 +0100

Background: The surgical insult induces an inflammatory response that activates P38 MAP kinases and solid tumours can also release cytokines. Therfore inhibition of these pathways may reduce tumour growth We set out to examine the effects of P38-MAPK inhibition on apoptosis, proliferation, VEGF release and cell cycle effects in-vitro and on primary tumour growth in-vivo. Methods: 4T-1 cells (2x105cells/well) were incubated, in 24 well plates with control, 25, 50 or 100ng/ml of SB-202190 for 24 hours. Cells were subsequently asessed for apoptosis, proliferation, VEGF release and cell cycle analysis. Balb-c mice each received 1x106 4T1 cells subcutaneously in the flank and were then randomised to receive control or SB202190 (2.5 muM/kg) by intraperitoneal injection daily. Tumour size was m...

Relapse in resected lung cancer revisited: does intensified follow up really matter? A prospective study

World Journal of Surgical Oncology — Thu, 12 Nov 2009 00:00:00 +0100

Conclusions: the intensified follow up did not increase either the proportion of patients detected with asymptomatic relapse or the number of patients with specific oncological treatment of relapse. (Source: World Journal of Surgical Oncology)

Serum estradiol should be monitored not only during the peri-menopausal period but also the post-menopausal period at the time of aromatase inhibitor administration

World Journal of Surgical Oncology — Thu, 12 Nov 2009 00:00:00 +0100

Conclusion: The results indicate that, in some breast cancer patients with ordinary menopause, E2 rebounds following AI therapy. In the future, E2 monitoring should be performed for a larger number of patients being administered AI therapy.Trial registration: Our trial registration number is 19-11-1211. (Source: World Journal of Surgical Oncology)

Primary pleomorphic adenoma of minor salivary gland in the parapharyngeal space

World Journal of Surgical Oncology — Thu, 12 Nov 2009 00:00:00 +0100

Conclusions: Pleomorphic adenoma arising de novo in the parapharyngeal space is of rare occurrence. High index of suspicion and an adequate clearance of the tumour with a cuff of surrounding dispensable normal tissues is the key to successful treatment of such tumours. (Source: World Journal of Surgical Oncology)

Frontal skull craniotomy combined with moderate-dose radiotherapy effectively ameliorate a rare case of non-secretory, multiple myeloma with orbital involvement

World Journal of Surgical Oncology — Thu, 12 Nov 2009 00:00:00 +0100

Conclusion: Although the effectiveness and applicability of this approach remains to be determined, this case report demonstrates that accurate and early detection combined with local surgical treatment and appropriate radio/chemotherapy, can be applied to effectively extend an orbital multiple myeloma patient's life. (Source: World Journal of Surgical Oncology)

Late cutaneous metastases to the face from malignant pleural mesothelioma: A case report and review of the literature

World Journal of Surgical Oncology — Mon, 09 Nov 2009 00:00:00 +0100

Conclusion: Mesothelioma metastases should be suspected in any known Mesothelioma patient with newly developed skin lesion. (Source: World Journal of Surgical Oncology)

Comparison of immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) assessment for Her-2 status in breast cancer

World Journal of Surgical Oncology — Mon, 09 Nov 2009 00:00:00 +0100

We report a prospective study to reflect the concordance between IHC and FISH in Guilin city, People's Republic of China. Methods: Fifty cases of invasive ductal carcinoma of breast tested by IHC and scored as 0, 1+, 2+ and 3+ by pathologists were further analyzed by FISH using a commercially available double-color probe, and the FISH findings were compared with IHC testresults. Results: A total concordance of 82.0% was observed with a Kappa coefficient of 0.640 (P (Source: World Journal of Surgical Oncology)

Urachal tumour: case report of a poorly understood carcinoma

World Journal of Surgical Oncology — Sat, 07 Nov 2009 00:00:00 +0100

Conclusions: The urachus is the embryological remnant of urogenital sinus and allantois. Involution usually happens before birth and urachus is present as a median umbilical ligament. The pathogenesis of urachal tumours is not fully understood. Surgery is the treatment of choice and role of adjuvant treatment is not clearly understood. (Source: World Journal of Surgical Oncology)

Composite paraganglioma-ganglioneuroma in the retroperitoneum

World Journal of Surgical Oncology — Thu, 05 Nov 2009 00:00:00 +0100

We present an unusual case of retroperitoneal composite paraganglioma-ganglioneuroma discovered on computed tomography in a 63-year-old female patient. Routine hematological examination and biochemical tests were within normal limits. Plasma adrenaline was 0.042 ng/ml, plasma noradrenaline 0.341 ng/ml, and plasma dopamine (Source: World Journal of Surgical Oncology)

Transarterial chemoembolisation (TACE) using irinotecan-loaded beads for the treatment of unresectable metastases to the liver in patients with colorectal cancer: an interim report

World Journal of Surgical Oncology — Tue, 03 Nov 2009 00:00:00 +0100

Conclusions: Chemoembolization using Irinotecan loaded beads was safe and effective in the treatment of patients as demonstrated by a minimal complication rate and acceptable tumor response. (Source: World Journal of Surgical Oncology)

Novel deployment of a covered duodenal stent in open surgery to facilitate closure of a malignant duodenal perforation

World Journal of Surgical Oncology — Tue, 27 Oct 2009 00:00:00 +0100

Conclusion: We describe a novel technique using a covered duodenal stent deployed at open surgery to aid closure of a malignant duodenal perforation. (Source: World Journal of Surgical Oncology)

Liposarcoma of the colon presenting as an endoluminal mass

World Journal of Surgical Oncology — Thu, 22 Oct 2009 23:00:00 +0100

Conclusions: Although no guidelines are available for the management of liposarcoma of the colon, surgical resection should be performed when feasible. Our patient's overall survival was satisfactory in spite of the multiple negative prognostic factors. (Source: World Journal of Surgical Oncology)

Predictive factors for breast cancer in patients diagnosed atypical ductal hyperplasia at core needle biopsy

World Journal of Surgical Oncology — Thu, 22 Oct 2009 23:00:00 +0100

Conclusions: Age (over 50-years) at the time of biopsy is an independent predictive factor for breast cancer at surgical excision in patients with diagnosed ADH at CNB. For patients diagnosed with ADH at CNB, only complete surgical excision is the suitable treatment option, because we could not find any combination of factors that can safely predict the absence of DCIS or invasive cancer in a case of ADH. (Source: World Journal of Surgical Oncology)

Clinical experience of novel interconnected porous hydroxyapatite ceramics for the revision of tumor prosthesis: a case report

World Journal of Surgical Oncology — Tue, 20 Oct 2009 23:00:00 +0100

Conclusion: When revision of uncemented tumor prostheses of the distal femur was performed, we avoided fibula graft by using Neobone with the patient's own bone tissue. Our experience with this case may indicate that adequate strength is achieved. (Source: World Journal of Surgical Oncology)

Superior vena cava (SVC) reconstruction using autologous tissue in two cases of differentiated thyroid carcinoma presenting with SVC syndrome

World Journal of Surgical Oncology — Mon, 12 Oct 2009 23:00:00 +0100

Herein, we report two extremely rare cases of differentiated thyroid carcinoma (DTC) with extended tumor thrombus or mediastinum lymph node metastasis (LNM) involving the superior vena cava (SVC), causing SVC syndrome. Both of these patients were successfully treated with radical resection and reconstruction of the SVC using autologous tissue instead of an expanded polytetrafluoroethylene (ePTFE) graft. The left brachiocephalic vein was used to reconstruct the SVC in a papillary thyroid carcinoma patient with mediastinum LNM and a pericardial patch was used in a follicular thyroid carcinoma patient with tumor thrombus. Our search of the English-language literature found sporadic reports of SVC resection with reconstruction by vascular graft (ePTFE), interposed between the brachiocephalic v...

Retroperitoneal abscess complicated with necrotizing fasciitis of the thigh in a patient with sigmoid colon cancer

World Journal of Surgical Oncology — Tue, 06 Oct 2009 23:00:00 +0100

Conclusion: Necrotizing fasciitis of the thigh due to the spread of sigmoid colon cancer is unusual, but this fatal complication should be considered during chemotherapy for patients with unresectable colorectal cancer. (Source: World Journal of Surgical Oncology)

Clostridium septicum sepsis and colorectal cancer - a reminder

World Journal of Surgical Oncology — Mon, 05 Oct 2009 23:00:00 +0100

Conclusion: Although uncommon, the possibility of clostridium septicum sepsis should be borne in mind in patients who present with underlying malignancy and have sepsis. The cumulative effect of sepsis and malignant perforation is associated with a high morbidity and mortality. Awareness and early diagnosis of clostridium septicum may improve the prognosis of what is usually regarded as a fatal infection. (Source: World Journal of Surgical Oncology)

Update and Review of the Multidisciplinary Management of Stage IV Colorectal Cancer with Liver Metastases

World Journal of Surgical Oncology — Mon, 28 Sep 2009 23:00:00 +0100

Conclusions: Improvements in modern day chemotherapy has allowed clinicians to pursue a more aggressive surgical approach in the management of stage IV colorectal cancer with CLM. Additionally, locoregional and adjunctive therapies has expanded the armamentarium of treatment options available. As a result, the management of patients with CLM requires a comprehensive, multidisciplinary approach utilizing various modalities and a more aggressive approach may now be pursued in patients with stage IV colorectal cancer with CLM to achieve optimal outcomes. (Source: World Journal of Surgical Oncology)

Vulvar fibroadenoma: a common neoplasm in an uncommon site

World Journal of Surgical Oncology — Sun, 27 Sep 2009 23:00:00 +0100

We report a case of a 19 years old woman with a large slow growing mass in the right labia majora with the final diagnosis of fibroadenoma with mammary tissue surrounding it and positive hormone receptors. In this case, we support the origin in ectopic mammary tissue. (Source: World Journal of Surgical Oncology)

The stylomastoid artery as an anatomical landmark to the facial nerve during parotid surgery: a clinico-anatomic study

World Journal of Surgical Oncology — Sun, 27 Sep 2009 23:00:00 +0100

Conclusion: This anatomical aid, the stylomastoid artery, when supplemented by the other more commonly known anatomical landmarks and intra-operative facial nerve monitoring further reduces the risk of iatrogenic facial nerve damage and operative time. (Source: World Journal of Surgical Oncology)

Gastric cancer: predictors of recurrence when lymph-node dissection is inadequate

World Journal of Surgical Oncology — Wed, 16 Sep 2009 23:00:00 +0100

Conclusions: Invasion depth of tumor and LNR were independent predictors ofrecurrence in gastric cancer after potentially curative resection with an inadequatenumber of lymph nodes examined. (Source: World Journal of Surgical Oncology)

Surgical management of giant Brunner's gland hamartoma: case report and literature review

World Journal of Surgical Oncology — Tue, 01 Sep 2009 23:00:00 +0100

We report here an unusual case of a giant BGH that was not amenable to endoscopic or surgical local resection thus requiring a pancreaticoduodenectomy for extirpation. The relevant literature is discussed. (Source: World Journal of Surgical Oncology)

Central pancreatectomy without anastomosis

World Journal of Surgical Oncology — Sun, 30 Aug 2009 23:00:00 +0100

Conclusions: Central pancreatectomy without pancreatico-enteric anastomosis for lesions in the neck and proximal pancreas is a safe and effective procedure. Morbidity is low because there is no anastomosis. Long term endocrine and exocrine function has been maintained. (Source: World Journal of Surgical Oncology)

Body image disturbance and surgical decision making in egyptian post menopausal breast cancer patients

World Journal of Surgical Oncology — Wed, 12 Aug 2009 23:00:00 +0100

Conclusion: Body image is an important factor for postmenopausal women with breast cancer in developing countries where that concept is widely ignored. We should not deprive those cases from their right of less mutilating option of treatment as BCT. (Source: World Journal of Surgical Oncology)

Supracricoid hemilaryngopharyngectomy for selected pyriform sinus carcinoma patients - a retrospective chart review

World Journal of Surgical Oncology — Mon, 10 Aug 2009 23:00:00 +0100

Conclusions: Supracricoid hemilaryngopharyngectomy in experienced hands is a reliable technique for selected patients with pyriform sinus cancer. (Source: World Journal of Surgical Oncology)

Incidental thyroid lesions detected by FDG-PET/CT: prevalence and risk of thyroid cancer

World Journal of Surgical Oncology — Sun, 09 Aug 2009 23:00:00 +0100

Background: Incidentally found thyroid lesions are frequently detected in patients undergoing FDG-PET/CT. The aim of this study was to investigate the prevalence of incidentally found thyroid lesions in patients undergoing FDG-PET/CT and determine the risk for thyroid cancer. Methods: FDG-PET/CT was performed on 3,379 patients for evaluation of suspected or known cancer or cancer screening without any history of thyroid cancer between November 2003 and December 2005. Medical records related to the FDG-PET/CT findings including maximum SUV(SUVmax) and pattern of FDG uptake, US findings, FNA, histopathology received by operation were reviewed retrospectively. Results: Two hundred eighty five patients (8.4%) were identified to have FDG uptake on FDG-PET/CT. 99 patients with focal or diffuse F...

Uncommon mucosal metastases to the stomach

World Journal of Surgical Oncology — Sun, 02 Aug 2009 23:00:00 +0100

Conclusions: While the accurate recognition of these lesions at endoscopy is fraught with difficulty, pathological awareness of such uncommon metastases in the gastric mucosa is essential for accurate diagnosis and optimal patient management. (Source: World Journal of Surgical Oncology)

Gastrointestinal stromal tumor

World Journal of Surgical Oncology — Fri, 31 Jul 2009 23:00:00 +0100

Conclusion: The clinical presentation of GIST is variable but the most usual symptoms include the presence of a mass or bleeding. Surgical resection of the local disease is the mainstay therapy. However, therapeutic agents, such as Imatinib have now been approved for the treatment of advanced GISTs and others such as everolimus, rapamycin, heat shock protein 90 and IGF are in trial stage demonstrate promising results for the management of GISTs. (Source: World Journal of Surgical Oncology)

Mantle cell lymphoma of the gastrointestinal tract presenting with multiple intususceptions - a case report and review of literature

World Journal of Surgical Oncology — Thu, 30 Jul 2009 23:00:00 +0100

Conclusion: This is a rare case of intestinal polyposis due to Mantle cell lymphoma presenting with multiple small bowel intussusceptions. The literature is reviewed and discussed. (Source: World Journal of Surgical Oncology)

Mesenteric rheumatoid nodules masquerading as an intra-abdominal malignancy: a case report and review of the literature

World Journal of Surgical Oncology — Tue, 14 Jul 2009 23:00:00 +0100

Conclusion: Rheumatoid nodules should be considered in the differential diagnosis of a patient who presents with an intra-abdominal mass and a history of rheumatoid arthritis. Currently, no tests or imaging modality can discriminate with sufficient accuracy to rule out a malignancy in this difficult diagnostic delimma. Hopefully, this case will serve as impetus for further study and biomarker discovery to allow for improved diagnostic power. (Source: World Journal of Surgical Oncology)

Spontaneous pneumothorax as a first sign of pulmonary carcinoma

World Journal of Surgical Oncology — Mon, 29 Jun 2009 23:00:00 +0100

Conclusions: Spontaneous pneumothorax in association with lung cancer is rarely seen. Pneumothorax can be the first sign of lung cancer. The most common possibility for SP complicating lung cancer is the tumor necrosis mechanism or, in separate cases, rupture of the emphysematous bullae. Lung cancer should always be considered as a possible cause of SP in elderly patients or in heavy smokers. (Source: World Journal of Surgical Oncology)

Leiomyosarcoma of the inferior vena cava: Radical surgery and vascular reconstruction

World Journal of Surgical Oncology — Thu, 25 Jun 2009 23:00:00 +0100

Conclusions: This paper presents two cases of successfully managed leiomyosarcomas of the vena cava and exemplifies two different options for vascular reconstruction in level II sarcomas and includes a thorough review of the literature. (Source: World Journal of Surgical Oncology)

Primary hepatic embryonal sarcoma masquerading as metastatic ovarian cancer

World Journal of Surgical Oncology — Mon, 22 Jun 2009 23:00:00 +0100

Conclusions: Primary liver tumors should be considered in differential diagnoses in patients with ovarian cancer who subsequently present with liver tumors. This is particularly important when there is no direct evidence of recurrence of ovarian cancer. (Source: World Journal of Surgical Oncology)

Ectopic pancreatic-type malignancy presenting in a Meckel's diverticulum: a case report and review of the literature

World Journal of Surgical Oncology — Sun, 21 Jun 2009 23:00:00 +0100

Conclusion: We believe this is the first case of pancreatic adenocarcinoma in a Meckel's diverticulum to be reported in the literature. The diagnosis of Meckel's should be considered in patients with acute gastrointestinal complaints; when found incidentally at laparotomy, it should be carefully examined for any gross abnormality and resection should be considered. (Source: World Journal of Surgical Oncology)

Spontaneous regression in alveolar soft part sarcoma: case report and literature review

World Journal of Surgical Oncology — Wed, 10 Jun 2009 04:00:00 +0100

Conclusions: ASPS is a rare type of sarcomas that affect primarily the lower limbs. This tumor does rarely metastasize to the gastrointestinal tract. (Source: World Journal of Surgical Oncology)

Surgical treatment for locally advanced lower third rectal cancer after neoadjuvent chemoradiation with capecitabine: prospective phase II trial

World Journal of Surgical Oncology — Tue, 09 Jun 2009 04:00:00 +0100

Conclusion: In patients with low lying, locally advanced rectal cancer, preoperative chemoradiation using oral capecitabine 825 mg/m2, twice a day on radiotherapy days, was tolerable and effective in downstaging and resulted in 46.5% anal sphincter preservation rate. (Source: World Journal of Surgical Oncology)

Incidence of synchronous appendiceal neoplasm in patients with colorectal cancer and its clinical significance

World Journal of Surgical Oncology — Tue, 02 Jun 2009 04:00:00 +0100

Conclusions: The incidence of synchronous primary appendiceal neoplasm and secondary (metastatic) appendiceal neoplasm in colorectal cancer patients was 0.3 and 1.0 percent, respectively. However, these findings did not change the postoperative clinical management. (Source: World Journal of Surgical Oncology)

Ruptured gallbladder as the first presentation of breast cancer

World Journal of Surgical Oncology — Mon, 01 Jun 2009 04:00:00 +0100

Conclusion: We present a rare case of gall bladder perforation from metastatic breast cancer. (Source: World Journal of Surgical Oncology)

The combination effect of sodium butyrate and 5-Aza-2'-deoxycytidine on radiosensitivity in RKO colorectal cancer and MCF-7 breast cancer cell lines

World Journal of Surgical Oncology — Thu, 21 May 2009 04:00:00 +0100

In this study, we investigated the effect of a demethylating agent, a histone deacetylase(HDAC) inhibitor ,and the two agents combined on radiosensitivity in human colon and breast cancer cell lines. Methods: In this study, we used RKO colorectal cancer cell line and MCF-7 breast cancer cell lines and normal colon cell lines. On each of the cell lines, we used three different agents: the HDAC inhibitor sodium butyrate(SB), the demethylating agent 5-Aza-2'-deoxycytidine(5-aza-DC), and radiation. We then estimated the percentage of the cell survival using the XTT method and experimented to determine if there was an augmentation in the therapeutic effect by using different combinations of the two or three of the treatment methods. Results: After treatment of each cell lines with 5-aza-DC, SB ...

Mucinous cystic neoplasms of the mesentery: a case report and review of the literature

World Journal of Surgical Oncology — Tue, 19 May 2009 04:00:00 +0100

Conclusions: Mucinous cystic neoplasms of the mesentery present almost exclusively in women and must be considered in the differential diagnosis of mesenteric tumors. Only full histological examination of a mucinous cystic neoplasm can exclude a borderline or malignant component. An updated classification of mesenteric cysts and cystic tumors is proposed. (Source: World Journal of Surgical Oncology)

Management of appendiceal pseudomyxoma peritonei diagnosed during pregnancy

World Journal of Surgical Oncology — Tue, 19 May 2009 04:00:00 +0100

Conclusion: The management of an appendiceal tumor with pseudomyxoma peritonei diagnosed during pregnancy requires full knowledge of the natural history of this disease to achieve a balance of concern for maternal survival and fetal health. (Source: World Journal of Surgical Oncology)

Ovarian serous adenocarcinoma identified during IVF: diagnostic approach, surgical management, and reproductive outcome

World Journal of Surgical Oncology — Thu, 14 May 2009 04:00:00 +0100

Conclusion: Suspicious adnexal structures noted during controlled ovarian hyperstimulation for IVF warrant assessment, and this report confirms the role of aspiration cytology in such cases. If uterine conservation is possible, successful livebirth can be achieved from IVF if donor oocyes are utilised, as described here. (Source: World Journal of Surgical Oncology)

Cutaneous skull metastasis from uterine leiomyosarcoma: a case report

World Journal of Surgical Oncology — Mon, 11 May 2009 04:00:00 +0100

Conclusions: The appearance of a cutaneous nodule in a patient with a history of uterine leiomyosarcoma might indicate a metastatic tumor lesion. Biopsy and immunohistochemistry are essential for correct diagnosis. (Source: World Journal of Surgical Oncology)

The "Win-Win" initiative: a global, scientifically based approach to resource sparing treatment for systemic breast cancer therapy

World Journal of Surgical Oncology — Tue, 05 May 2009 04:00:00 +0100

Conclusions: The intended result would assure sustained affordability and accessibility in breast cancer systemic therapy for patients in low and middle income countries. As an added benefit, the example of breast cancer could be expanded to include other cancers in diverse settings around the world. (Source: World Journal of Surgical Oncology)

Synchronous infiltrating ductal carcinoma and primary extramedullary plasmacytoma of the breast

World Journal of Surgical Oncology — Fri, 24 Apr 2009 04:00:00 +0100

Conclusion: In this case, careful histopathology examination was essential to make the correct diagnosis and therapy for these synchronous lesions. The patient finished chemotherapy and radiotherapy without significant adverse effects. (Source: World Journal of Surgical Oncology)

Myxoid liposarcoma: a rare soft-tissue tumor with a misleading benign appearance

World Journal of Surgical Oncology — Wed, 22 Apr 2009 04:00:00 +0100

Conclusions: When any suspicious soft-tissue tumor is diagnosed, the combined information gathered from accurate preoperative radiographic planning and X-rays or surgical biopsy is of tremendous value for establishing the most appropriate therapeutic program, highly adapted to the histopathological findings. (Source: World Journal of Surgical Oncology)

Intramucosal adenocarcinoma of the ileum originated 40 years after ileosigmoidostomy

World Journal of Surgical Oncology — Tue, 21 Apr 2009 04:00:00 +0100

Conclusion: Adenocarcinoma of the ileum at such an early stage is a very rare event. In this case, there is a possibility that the ileosigmoidostomy resulted in a back flow of colonic stool to the ileum that caused the carcinogenesis of the small intestine. (Source: World Journal of Surgical Oncology)

Venous obstruction of thyroid malignancy origin: the Antoine Lacassagne Institute experience

World Journal of Surgical Oncology — Fri, 17 Apr 2009 04:00:00 +0100

Conclusion: Despite small numbers of patients, it seems that aggressive treatment modalities including surgery are required to improve survival. In our experience, US was a useful non-invasive method to describe tumor extensions to great veins of the neck (invasion versus compression, tumor thrombus versus blood clot) and should be recommended to depict early venous invasion in cases of suspected thyroid malignancy. (Source: World Journal of Surgical Oncology)

ACTH-producing carcinoma of the pituitary with refractory Cushing's Disease and hepatic metastases: a case report and review of the literature

World Journal of Surgical Oncology — Wed, 08 Apr 2009 04:00:00 +0100

Conclusions: Pituitary carcinomas are extremely rare neoplasms, representing only 0.1% to 0.2% of all pituitary tumors. To date, little is understood about the molecular basis of malignant transformation. The latency period between initial presentation of a pituitary adenoma and the development of distal metastases marking carcinoma is extremely variable, and some patients may live well over 10 years with pituitary carcinoma (Source: World Journal of Surgical Oncology)

Genomic and oncoproteomic advances in detection and treatment of colorectal cancer

World Journal of Surgical Oncology — Wed, 01 Apr 2009 04:00:00 +0100

Conclusions: If a set of discriminating genes could be used for characterization and prediction of chemotherapeutic response, an individualized tailored therapeutic regime could become the standard of care for those undergoing systemic treatment for colorectal cancer. New laboratory techniques of protein identification may eventually allow identification of a clinically useful biomarker that could be used for screening and treatment. At present however, both expression of different gene signatures and isolation of various protein peaks has been limited by study size. Independent multi-centre correlation of results with larger sample sizes is needed to allow translation into clinical practice. (Source: World Journal of Surgical Oncology)

A pilot study to assess the feasibility of evaluation of markers of response to chemotherapy at one day & 21 days after first cycle of chemotherapy in carcinoma of breast: a prospective non-randomized observational study

World Journal of Surgical Oncology — Mon, 30 Mar 2009 04:00:00 +0100

Conclusion: We report a detectable change in biomarkers as early as 24-48 hours after the first chemotherapy along with a definite trend in change that can possibly be used to predict response to chemotherapy in an individual patient. The statistical significance and clinical utility of such changes needs to be evaluated and confirmed in larger trials. (Source: World Journal of Surgical Oncology)

Comparison of intraoperative frozen section analysis for sentinel lymph node biopsy during breast cancer surgery for invasive lobular carcinoma and invasive ductal carcinoma

World Journal of Surgical Oncology — Tue, 24 Mar 2009 04:00:00 +0100

Conclusions: Since there was no statistically significant difference in sensitivity, specificity, accuracy, false negative rate, negative predictive value, and positive predictive value between frozen section analysis of SLNs for patients with ILC and IDC, the clinical accuracy of confirming metastatic involvement of SLNs on frozen section analysis for ILC should not be considered inferior to the clinical accuracy for IDC. Therefore, frozen section analysis of all SLNs during breast cancer surgery in patients with ILC should remain the standard of care in order to reduce the risk of the need of a later, separate axillary lymph node dissection. (Source: World Journal of Surgical Oncology)

Taurolidine reduces the tumor stimulating cytokine interleukin-1beta in patients with resectable gastrointestinal cancer: a multicentre prospective randomized trial

World Journal of Surgical Oncology — Mon, 23 Mar 2009 04:00:00 +0100

Conclusions: Reduced cytokine levels might explain a short term antitumorigenic intraperitoneal effect of TRD. But, this study analyzed different types of cancer. Therefore, we set up a multicentre randomized trial in patients undergoing curative colorectal cancer resection. Trial registration: ISRCTN66478538 (Source: World Journal of Surgical Oncology)

Synchronous colorectal adenocarcinoma and gastrointestinal stromal tumor in Meckel's diverticulum; an unusual association

World Journal of Surgical Oncology — Mon, 23 Mar 2009 04:00:00 +0100

Conclusions: Whenever GIST is encountered, the surgeon should be alert to recognize a possible coexistent tumor with different histological origin. Correct diagnosis of synchronous tumors of different origin is the cornerstone of treatment. (Source: World Journal of Surgical Oncology)

A giant hemolymphangioma of the pancreas in a 20-year-old girl: a report of one case and review of the literature

World Journal of Surgical Oncology — Wed, 18 Mar 2009 04:00:00 +0100

Conclusion: From this case and literature, we can conclude that hemolymphangioma of the pancreas in adult is a rare benign tumor, and accurate diagnosis can not be preoperatively established. Tumor resection should be performed whenever possible. The risk of recurrence seems very low. (Source: World Journal of Surgical Oncology)

Dramatic response of a gastrointestinal stromal tumor to neadjuvant imatinib therapy

World Journal of Surgical Oncology — Mon, 16 Mar 2009 04:00:00 +0100

We report the case of a 61-year old man who was treated with neoadjuvant imatinib for a massive gastric GIST with the hope of avoiding a potential multi-visceral resection. (Source: World Journal of Surgical Oncology)

Gastric outlet obstruction due to adenocarcinoma in a patient with Ataxia-Telangiectasia syndrome: a case report and review of the literature

World Journal of Surgical Oncology — Thu, 12 Mar 2009 04:00:00 +0100

Conclusions: A literature search of adenocarcinoma associated with ataxia-telangiectasia revealed 6 cases. All patients presented with non-specific gastrointestinal complaints suggestive of ulcer disease. Although there was no correlation between immunoglobulin levels and development of gastric adenocarcinoma, the presence of chronic gastritis and intestinal metaplasia seem to lead to the development of gastric adenocarcinoma. One should consider adenocarcinoma in any patient with ataxia-telangiectasia who presents with non-specific gastrointestinal complaints, since this can lead to earlier diagnosis. (Source: World Journal of Surgical Oncology)

Outcomes of resection and non-resection strategies in management of patients with advanced colorectal cancer

World Journal of Surgical Oncology — Tue, 10 Mar 2009 04:00:00 +0100

Conclusion: In an unselected bowel cancer population surgical resection of the primary tumour in patients presenting with incurable disease does not improve survival and is associated with a high risk of post-operative mortality. (Source: World Journal of Surgical Oncology)

Mucin pattern reflects the origin of the adenocarcinoma in Barrett's esophagus: a retrospective clinical and laboratorial study

World Journal of Surgical Oncology — Mon, 09 Mar 2009 04:00:00 +0100

Conclusions: Barrett's esophagus adenocarcinoma shows either gastric or intestinal type pattern of mucin expression. The two types of tumors developed in Barrett's esophagus may reflect the original cell type involved in the malignant transformation. (Source: World Journal of Surgical Oncology)

Lymphangiosis carcinomatosa in squamous cell carcinomas of larynx and hypopharynx – value of conventional evaluation and additional immunohistochemical staining of D2-40

World Journal of Surgical Oncology — Wed, 04 Mar 2009 05:00:00 +0100

Conclusion: The status of lymphatic vessel invasion should be documented in standardized tumor reports. A benefit of an additional immunohistochemical investigation was not found, for the daily routine HE-stain seems sufficient. (Source: World Journal of Surgical Oncology)

Tongue carcinoma in an adult Down's syndrome patient: a case report

World Journal of Surgical Oncology — Wed, 04 Mar 2009 05:00:00 +0100

Conclusions: To our knowledge, this is the first case of tongue carcinoma arising in a patient with Down's syndrome. This unique case might not be sufficient to make a significant conclusion on the prognosis and survival of these patients but will increase the awareness about this possibility and will help in the appropriate management of Down's syndrome patients. (Source: World Journal of Surgical Oncology)

Intraoperative radiation therapy in the treatment of early-stage breast cancer utilizing xoft axxent electronic brachytherapy

World Journal of Surgical Oncology — Mon, 02 Mar 2009 05:00:00 +0100

Conclusions: Further research on XB and other methods of IORT is needed to establish clinical efficacy and safety for patients with early-stage breast cancer (Source: World Journal of Surgical Oncology)

Curative resection of a primarily unresectable acinar cell carcinoma of the pancreas after chemotherapy

World Journal of Surgical Oncology — Wed, 25 Feb 2009 05:00:00 +0100

Conclusions: ACC responded well to 5-FU monochemotherapy. Therefore, neoadjuvant chemotherapy could be an option to reduce a primarily unresectable ACC to a point where curative resection can be achieved. (Source: World Journal of Surgical Oncology)

Synchronous association of rectal adenocarcinoma and three ileal carcinoids: a case report

World Journal of Surgical Oncology — Thu, 19 Feb 2009 05:00:00 +0100

Conclusions: During resection of a gastrointestinal tumour, a thorough inspection of the abdominal cavity should be undertaken to investigate the possibility of metastatic secondaries or a synchronous tumour as is reported in this case. (Source: World Journal of Surgical Oncology)

Serous adenocarcinoma of the fallopian tube, associated with verrocous carcinoma of the uterine cervix: a case report of synchronic rare gynecological tumors

World Journal of Surgical Oncology — Tue, 17 Feb 2009 05:00:00 +0100

Conclusions: Reasons for our presentation of this work are: first, due to the rarity of these, and second, because of the usefulness of possessing a case report for establishing a norm for later behavior with respect to treatment of these patients. (Source: World Journal of Surgical Oncology)

Brachytherapy versus radical hysterectomy after external beam chemoradiation: a non-randomized matched comparison in IB2-IIB cervical cancer patients

World Journal of Surgical Oncology — Mon, 16 Feb 2009 05:00:00 +0100

Conclusions: The results of this study suggest that radical hysterectomy can be used after EBRT-CT without compromising survival in FIGO stage IB2-IIB cervical cancer patients in settings were brachytherapy is not available. A randomized study is needed to uncover the value of surgery after EBRT-CT. (Source: World Journal of Surgical Oncology)

Pancreatic insulinoma co-existing with gastric GIST in the absence of neurofibromatosis-1

World Journal of Surgical Oncology — Fri, 13 Feb 2009 05:00:00 +0100

Background: Gastrointestinal stromal tumours (GIST) frequently occur in patients with neurofibromatosis type 1 (NF-1). It has been reported that GIST may co-exist with pancreatic endocrine tumors but this has only been in association with NF-1. Case presentationA 76 year old woman presented with a 12 month history of hypoglycaemia symptoms. Abdominal CT scan demonstrated a 13mm insulinoma localized in the tail of her pancreas. She was commenced on diazoxide and later underwent surgery for enucleation of insulinoma when a small ( (Source: World Journal of Surgical Oncology)

Interstitial pneumonitis following intrapleural chemotherapy

World Journal of Surgical Oncology — Thu, 12 Feb 2009 05:00:00 +0100

Conclusion: This manuscript is the first case report describing interstitial pneumonitis and lung fibrosis following intrapleural chemotherapy. Since pulmonary toxicity from chemotherapy is a dose-dependent phenomenon, dose reduction of intrapleural as compared to intraperitoneal hyperthermic chemotherapy may be necessary. (Source: World Journal of Surgical Oncology)

Intradural squamous cell carcinoma in the sacrum

World Journal of Surgical Oncology — Wed, 11 Feb 2009 05:00:00 +0100

Conclusions: We report the first case of a patient with intradural squamous cell carcinoma with unknown origin that developed independently in the sacrum. (Source: World Journal of Surgical Oncology)

Proximal major limb amputations - a retrospective analysis of 45 oncological cases

World Journal of Surgical Oncology — Mon, 09 Feb 2009 05:00:00 +0100

Conclusions: Proximal major limb amputations severely interfere with patients' body function and are the last, albeit valuable, option within the treatment concept of extremity malignancies or severe infections. Besides short survival, high complication rates, and postoperative pain, patients' quality of life can be improved for the time they have remaining. (Source: World Journal of Surgical Oncology)

A rare coexistence of adrenal cavernous hemangioma with extramedullar hemopoietic tissue: a case report and brief review of the literature

World Journal of Surgical Oncology — Thu, 05 Feb 2009 05:00:00 +0100

Conclusions: Although adrenal hemangiomas are rare and their preoperative diagnosis is difficult, they should always be included in the differential diagnosis of adrenal neoplasms. (Source: World Journal of Surgical Oncology)

Diagnosis and management of retroperitoneal ancient schwannomas

World Journal of Surgical Oncology — Mon, 02 Feb 2009 05:00:00 +0100

Conclusions: A diagnosis of ancient schwannoma should be entertained for any heterogeneous, well encapsulated mass in the retroperitoneum. In these cases less radical surgical resection should be considered as malignant transformation of these tumors is extremely rare and recurrence is uncommon following excision. (Source: World Journal of Surgical Oncology)

A comprehensive overview of radioguided surgery using gamma detection probe technology

World Journal of Surgical Oncology — Tue, 27 Jan 2009 05:00:00 +0100

The concept of radioguided surgery, which was first developed some 60 years ago, involves the use of a radiation detection probe system for the intraoperative detection of radionuclides. The use of gamma detection probe technology in radioguided surgery has tremendously expanded and has evolved into what is now considered an established discipline within the practice of surgery, revolutionizing the surgical management of many malignancies, including breast cancer, melanoma, and colorectal cancer, as well as the surgical management of parathyroid disease. The impact of radioguided surgery on the surgical management of cancer patients includes providing vital and real-time information to the surgeon regarding the location and extent of disease, as well as regarding the assessment of surgical...

Minute ampullary carcinoid tumor with lymph node metastases: a case report and review of literature

World Journal of Surgical Oncology — Thu, 22 Jan 2009 05:00:00 +0100

Conclusion: Recently there have been some reports of endoscopic ampullectomy for small carcinoid tumors. However, this case suggests that attention should be paid to the possibility of lymph node metastases as well as that of regional infiltration of the tumor even for minute ampullary carcinoid tumors to provide the best chance for cure. (Source: World Journal of Surgical Oncology)

A case of Meigs syndrome mimicking metastatic breast carcinoma

World Journal of Surgical Oncology — Thu, 22 Jan 2009 05:00:00 +0100

Conclusions: Despite the high probability of disseminated malignancy when an ovarian mass associated with ascites if found in a patient with a breast cancer and pleural effusion, clinicians should be aware about rare benign syndromes, like Meigs', which may mimic a similar picture and mislead the diagnosis and management plan. (Source: World Journal of Surgical Oncology)

When is a GIST not a GIST? A case report of synchronous metastatic gastrointestinal stromal tumor and fibromatosis

World Journal of Surgical Oncology — Wed, 21 Jan 2009 05:00:00 +0100

Conclusions: Differentiating localized progression of GIST from other diseases has important prognostic and therapeutic implications. The potential for co-existence of non-malignant soft tissue neoplasm should always be considered. (Source: World Journal of Surgical Oncology)

Perioperative immune responses in cancer patients undergoing digestive surgeries

World Journal of Surgical Oncology — Mon, 12 Jan 2009 05:00:00 +0100

Conclusions: Patients with malignancy showed an abnormal perioperative Th1/Th2 balance suggesting predominance of a type-2 immune response. Major abdominal surgeries induce a marked shift in Th1/Th2 balance toward Th2 in the early postoperative stage. (Source: World Journal of Surgical Oncology)

Peritoneal carcinomatosis: patients selection, perioperative complications and quality of life related to cytoreductive surgery and hyperthermic intraperitoneal chemotherapy

World Journal of Surgical Oncology — Thu, 08 Jan 2009 05:00:00 +0100

Conclusions: Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) provide a promising combined treatment strategy for selected patients with peritoneal carcinomatosis that can improve patient survival and quality of life. The extent of intraperitoneal tumor dissemination and the completeness of cytoreduction are the leading predictors of postoperative patient outcome. Thus, consistent preoperative diagnostics and patient selection are crucial to obtain a complete macroscopic cytoreduction (CCR-0/1). (Source: World Journal of Surgical Oncology)

Preoperative Y-90 microsphere selective internal radiation treatment for tumor downsizing and future liver remnant recruitment: a novel approach to improving the safety of major hepatic resections

World Journal of Surgical Oncology — Thu, 08 Jan 2009 05:00:00 +0100

Conclusion: Selective internal radiation treatment (SIRT) with yttrium-90 (Y-90) microspheres has emerged as an effective liver-directed therapy with a favorable therapeutic ratio. We present this case report to suggest that the portal vein radiation dose can be substantially increased with the intent of inducing portal/periportal fibrosis. Such a therapeutic manipulation in lobar Y-90 microsphere treatment could accomplish the end points of PVE with avoidance of the concern regarding tumor progression. (Source: World Journal of Surgical Oncology)

Intraductal and invasive adenocarcinoma of duct of Luschka, mimicking chronic cholecystitis and cholelithiasis

World Journal of Surgical Oncology — Wed, 07 Jan 2009 05:00:00 +0100

Conclusion: Adenocarcinoma of ducts of Luschka should be considered among differential diagnoses for the patients with typical clinical presentations of chronic cholecystitis and cholelithiasis. (Source: World Journal of Surgical Oncology)

Does Doxycycline work in synergy with cisplatin and oxaliplatin in colorectal cancer?

World Journal of Surgical Oncology — Tue, 06 Jan 2009 05:00:00 +0100

Conclusions: We concluded that doxycycline has role in apoptosis induction in the colorectal cancer. However, it did not show any synergy with platinum compounds in the colorectal cancer cells. This study also pointed towards possible caspase-independent actions of doxycycline with cisplatin and oxaliplatin. However, further work is required to underpin the mechanisms of actions of doxycycline. (Source: World Journal of Surgical Oncology)

Pancreatic and multiorgan resection with inferior vena cava reconstruction for retroperitoneal leiomyosarcoma

World Journal of Surgical Oncology — Tue, 06 Jan 2009 05:00:00 +0100

Conclusions: To our knowledge, this is the first case of resection of an IVC sarcoma with prosthetic graft reconstruction in combination with pancreatic resection. Aggressive surgical resection including vascular reconstruction is warranted for select IVC tumors to achieve a potentially curative outcome. (Source: World Journal of Surgical Oncology)

Hepatic splenosis mimicking HCC in a patient with hepatitis C liver cirrhosis and mildly raised alpha feto protein; the important role of explorative laparoscopy

World Journal of Surgical Oncology — Mon, 05 Jan 2009 05:00:00 +0100

Conclusion: Hepatic splenosis is not a rare event and should be suspected in patients with a history of splenic trauma or splenectomy. Correct diagnosis is essential and will determine subsequent management plans. In doubtful cases laparoscopic investigation can offere essential information and should be part of the standard protocol for investigating suspected splenosis. (Source: World Journal of Surgical Oncology)

A case of radiation-induced sternal malignant fibrous histiocytoma treated with neoadjuvant chemotherapy and surgical resection

World Journal of Surgical Oncology — Tue, 30 Dec 2008 05:00:00 +0100

Conclusions: Neoadjuvant chemotherapy was an effective method. In planning the surgical resection, the size of the tumor before chemotherapy should be considered as the initial size and surgical margins should be determined accordingly. (Source: World Journal of Surgical Oncology)

Bilateral gluteal metastases from a misdiagnosed intrapelvic gastrointestinal stromal tumor

World Journal of Surgical Oncology — Tue, 30 Dec 2008 05:00:00 +0100

Conclusion: The correct diagnosis of the extra-gastrointestinal stromal tumor is a challenge even for experienced pathologists. CD117 (KIT) positivity is the most important immunohistochemical feature in the histological diagnosis. To our knowledge a metastatic EGIST (extra-gastrointestinal stromal tumor) to the skeletal muscle bilaterally has not been described previously in the English medical literature. (Source: World Journal of Surgical Oncology)

A rare tumoral combination, synchronous lung adenocarcinoma and mantle cell lymphoma of the pleura

World Journal of Surgical Oncology — Mon, 29 Dec 2008 05:00:00 +0100

Conclusions: This is the first reported case of a rare tumoral combination involving simultaneously lung and pleura, emphasizing at the incidental discovery of the two coexisting neoplasms during a procedure performed for a benign condition. Any tissue specimen resected during operations performed for non-tumoral conditions should be routinely sent for pathologic examination. (Source: World Journal of Surgical Oncology)

Advantage of vacuum assisted closure on healing of wound associated with omentoplasty after abdominoperineal excision: a case report

World Journal of Surgical Oncology — Tue, 23 Dec 2008 05:00:00 +0100

Conclusions: The satisfactory results showed in the present report appear to be favored by association of omentoplasty and VAC system. Those findings led us to favor VAC system in the case of pelvic exenteration associated with high risk of infection. (Source: World Journal of Surgical Oncology)

Squamous cell carcinoma of the breast: a case report

World Journal of Surgical Oncology — Sun, 21 Dec 2008 05:00:00 +0100

Conclusion: The presentation of squamous cell carcinoma could be similar to that of an adenocarcinoma. However, a squamous cell carcinoma of the breast could also develop from a complicated breast cyst or abscess. Therefore, pathological examination of these apparent benign abnormalities is mandatory. (Source: World Journal of Surgical Oncology)

Ileoileal intussusception induced by a gastrointestinal stromal tumor

World Journal of Surgical Oncology — Wed, 17 Dec 2008 05:00:00 +0100

Conclusions: This case presents an unusual malignant cause of adult intussusception and highlights the importance of computed tomography scanning in the accurate diagnosis of this rare entity. (Source: World Journal of Surgical Oncology)

Adrenocortical oncocytic carcinoma with recurrent metastases: a case report and review of the literature

World Journal of Surgical Oncology — Wed, 17 Dec 2008 05:00:00 +0100

Conclusions: Histological classification of adrenocortical oncocytic tumors has been so far a matter of debate. There is no officially established histological scoring system regarding these rare neoplasms and therefore many diagnostic difficulties occur for pathologists (Source: World Journal of Surgical Oncology)

A paraneoplastic manifestation of metastatic breast cancer responding to endocrine therapy: a case report

World Journal of Surgical Oncology — Tue, 16 Dec 2008 05:00:00 +0100

Conclusion: This case is an example of breast cancer presenting with paraneoplastic manifestations. It took several months to establish the cause of symptoms in this patient thus illustrating the need for physicians to maintain a high index of suspicion for paraneoplastic syndromes in women presenting with unusual neurological symptoms with no obvious cause. It is a unique case as it illustrates how treatment with an aromatase inhibitor leading to cancer regression can result in an improvement in the paraneoplastic symptoms. (Source: World Journal of Surgical Oncology)

Intramucosal leiomyosarcoma of the stomach following hereditary retinoblastoma in childhood - a case report and review of the literature

World Journal of Surgical Oncology — Sun, 14 Dec 2008 05:00:00 +0100

Conclusions: This is the unique report of an intramucosal gastric leiomyosarcoma and the first account of a gastric leiomyosarcoma after retinoblastoma in childhood. A careful clinical follow-up is advised because of increased risk of developing further metachronous malignancies. (Source: World Journal of Surgical Oncology)

Hepatobiliary cystadenoma exhibiting morphologic changes from simple hepatic cyst shown by 11-year follow up imagings

World Journal of Surgical Oncology — Thu, 11 Dec 2008 05:00:00 +0100

Conclusion: We believe this case provides evidence of a simple hepatic cyst gradually changing into hepatobiliary cystadenoma. (Source: World Journal of Surgical Oncology)

Post-radiation sciatic neuropathy: a case report and review of the literature

World Journal of Surgical Oncology — Thu, 11 Dec 2008 05:00:00 +0100

Conclusions: This is the first case of post-radiation involvement of the sciatic nerve reported in the literature. (Source: World Journal of Surgical Oncology)

A study of lymph node ratio in stage IV colorectal cancer

World Journal of Surgical Oncology — Mon, 01 Dec 2008 05:00:00 +0100

Background: The finding of metastasis in colorectal cancer, stage IV disease, has a major impact on prognosis and treatment strategy. Known important factors include the extent of the metastasis and the patients' performance status. The lymph node factors are of known importance in earlier cancer stages but less described in metastatic disease. The aim of the study was to evaluate lymph node status and ratio as prognostic markers in stage IV colorectal cancer.MethodThe study was retrospective and assessing all patients operated, with bowel resection, for an initial stage IV colorectal cancer during 1999-2003 (n=136). Basic demographic data as well as given treatment was assessed. The Lymph node ratio (LNR), the quota between the number of lymph node metastasis and assessed lymph nodes, was...

The use of fulvestrant, a parenteral endocrine agent, in intestinal obstruction due to metastatic lobular breast carcinoma

World Journal of Surgical Oncology — Mon, 01 Dec 2008 05:00:00 +0100

Conclusions: Fulvestrant may obviate the use of chemotherapy while achieving sustained clinical benefit with less toxicity, in appropriately selected patients. (Source: World Journal of Surgical Oncology)

The complicated management of a patient following transarterial chemoembolization for metastatic carcinoid

World Journal of Surgical Oncology — Tue, 25 Nov 2008 05:00:00 +0100

Conclusions: TACE remains an effective and safe treatment for metastatic carcinoid not amenable to resection, this case illustrates the complexity of complications that can arise. A multi-disciplinary approach including ready access to advanced critical care facilities is recommended in managing such complex patients. (Source: World Journal of Surgical Oncology)

Neoangiogenesis in early cervical cancer: Correlation between color Doppler findings and risk factors. A prospective observational study

World Journal of Surgical Oncology — Tue, 25 Nov 2008 05:00:00 +0100

Conclusion: The results are consistent with a relationship between tumor angiogenesis and prognostic factors for recurrence in early cervical cancer. "Abundant" vascularization and PI < 0.82 may be related to postoperative treatment due to risk factors. (Source: World Journal of Surgical Oncology)

Delayed malignant melanoma recurrence simulating primary ovarian cancer

World Journal of Surgical Oncology — Thu, 20 Nov 2008 05:00:00 +0100

Conclusions: Secondary ovarian involvement is associated with a poor prognosis and efforts should be made for adequate palliation. Pathologic diagnosis with non-invasive procedures is crucial in order to avoid unnecessary surgery. Surgical interventions may be undertaken only in selected cases of limited metastatic disease, where complete resection is expected (Source: World Journal of Surgical Oncology)

Giant breast tumors: Surgical management of phyllodes tumors, potential for reconstructive surgery and a review of literature