MedWorm: Biotechnology

Il-1 trap go-ahead

Nature Biotechnology — Sat, 17 May 2008 14:28:08 +0100

IL-1 trap go-ahead Nature Biotechnology 26, 485 (2008). doi:10.1038/nbt0508-485 Author: Mark Ratner (Source: Nature Biotechnology)

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Current perspectives on stability of protein drug products during formulation, fill and finish operations

Biotechnology Progress — Sat, 17 May 2008 14:12:27 +0100

Nitin Rathore and Rahul S. RajanWeb Release Date: Sat, 17 May 2008 00:00:00 EDT (Article) DOI: 10.1021/bp070462h (Source: Biotechnology Progress)

Antibacterial colorants: characterization of prodiginines and their applications on textile materials

Biotechnology Progress — Sat, 17 May 2008 04:00:00 +0100

Farzaneh Alihosseini, Kou-San Ju, Jozsef Lango, Bruce D. Hammock, and Gang SunWeb Release Date: Sat, 17 May 2008 00:00:00 EDT (Article) DOI: 10.1021/bp070481r (Source: Biotechnology Progress)

Forum to tout biotech efforts

bizjournals.com Health Care:Biotechnology headlines — Fri, 16 May 2008 18:34:22 +0100

Biotech 2008, a conference showcasing the top biotechnology companies and emerging startups from around North Carolina, will take place Monday and Tuesday in Winston-Salem, and will include a focus on efforts taking place outside Research Triangle Park. (Source: bizjournals.com Health Care:Biotechnology headlines)

Boston scientific heart failure treatment device gets fda approval

bizjournals.com Health Care:Biotechnology headlines — Fri, 16 May 2008 17:04:48 +0100

The U.S. Food and Drug Administration has approved a device Boston Scientific Corp. has developed to help treat heart failure, the company announced Friday. (BSX) (Source: bizjournals.com Health Care:Biotechnology headlines)

Labcorp launches new commercial test for prostate cancer

bizjournals.com Health Care:Biotechnology headlines — Fri, 16 May 2008 15:16:33 +0100

Laboratory Corp. of America Holdings said Friday it will launch the first commercial gene methylation test for key tissue markers in prostate cancer. (Source: bizjournals.com Health Care:Biotechnology headlines)

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Xanthus picked up by british firm antisoma for $52m

bizjournals.com Health Care:Biotechnology headlines — Fri, 16 May 2008 12:47:24 +0100

Xanthus Pharmaceuticals Inc. reports it has agreed to be acquired by Antisoma plc, a U.K.-based biotechnology company, for $52.2 million. (Source: bizjournals.com Health Care:Biotechnology headlines)

Ceg hosts biotech forum in nyc

bizjournals.com Health Care:Biotechnology headlines — Fri, 16 May 2008 12:27:15 +0100

The Center for Economic Growth Inc. is hosting a panel discussion on biotechnology in New York City. (Source: bizjournals.com Health Care:Biotechnology headlines)

Report says knowledge economy key to phila.-area's prosperity

bizjournals.com Health Care:Biotechnology headlines — Fri, 16 May 2008 12:23:13 +0100

The Philadelphia metropolitan area continues to grow its knowledge economy and the region's educational level is increasing along with it, according to Select Greater Philadelphia's State of the Region report. (Source: bizjournals.com Health Care:Biotechnology headlines)

Wiring-up hydrogenase with single-walled carbon nanotubes.

Nano Letters — Fri, 16 May 2008 04:00:00 +0100

Wiring-Up Hydrogenase with Single-Walled Carbon Nanotubes.

Nano Lett. 2008 May 16;

Authors: McDonald TJ

PMID: 18481895 [PubMed - as supplied by publisher]

(Source: Nano Letters)

Self-transducing silicon nanowire electromechanical systems at room temperature.

Nano Letters — Fri, 16 May 2008 04:00:00 +0100

Self-Transducing Silicon Nanowire Electromechanical Systems at Room Temperature.

Nano Lett. 2008 May 16;

Authors: He R, Feng XL, Roukes ML, Yang P

Electronic readout of the motions of genuinely nanoscale mechanical devices at room temperature imposes an important challenge for the integration and application of nanoelectromechanical systems (NEMS). Here, we report the first experiments on piezoresistively transduced very high frequency Si nanowire (SiNW) resonators with on-chip electronic actuation at room temperature. We have demonstrated that, for very thin ( approximately 90 nm down to approximately 30 nm) SiNWs, their time-varying strain can be exploited for self-transducing the devices' resonant motions at frequencies as high as approximately 100 MHz. The strain of wire elongation, which is only second-order in doubly clamped structures, enables efficient displacement transducer because of the enhanced piezoresistance effect in these SiNWs. This intrinsically integrated transducer is uniquely suited for a class of very thin wires and beams where metallization and multilayer complex patterning on devices become impractical. The 30 nm thin SiNW NEMS offer exceptional mass sensitivities in the subzeptogram range. This demonstration makes it promising to advance toward NEMS sensors based on ultrathin and even molecular-scale SiNWs, and their monolithic integration with microelectronics on the same chip.

PMID: 18481896 [PubMed - as supplied by publisher]

(Source: Nano Letters)

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Substantially improved pharmacokinetics of recombinant human butyrylcholinesterase by fusion to human serum albumin

BMC Biotechnology - Latest articles — Fri, 16 May 2008 04:00:00 +0100

Background: Human butyrylcholinesterase (huBChE) has been shown to be an effective antidote against multiple LD50 of organophosphorus compounds. A prerequisite for such use of huBChE is a prolonged circulatory half-life. This study was undertaken to produce recombinant huBChE fused to human serum albumin (hSA) and characterize the fusion protein. Results: Secretion level of the fusion protein produced in vitro in BHK cells was ~30 mg/liter. Transgenic mice and goats generated with the fusion constructs expressed in their milk a bioactive protein at concentrations of 0.04-1.1 g/liter. BChE activity gel staining and a size exclusion chromatography (SEC)-HPLC revealed that the fusion protein consisted of predominant dimers and some monomers. The protein was confirmed to have expected molecular mass of ~150 kDa by Western blot. The purified fusion protein produced in vitro was injected intravenously into juvenile pigs for pharmacokinetic study. Analysis of a series of blood samples using the Ellman assay revealed a substantial enhancement of the plasma half-life of the fusion protein (~32 h) when compared with a transgenically produced huBChE preparation containing >70% tetramer (~3 h). In vitro nerve agent binding and inhibition experiments indicated that the fusion protein in the milk of transgenic mice had similar inhibition characteristics compared to human plasma BChE against the nerve agents tested. Conclusion: Both the pharmacokinetic study and the in vitro nerve agent binding and inhibition assay suggested that a fusion protein retaining both properties of huBChE and hSA is produced in vitro and in vivo. The production of the fusion protein in the milk of transgenic goats provided further evidence that sufficient quantities of BChE/hSA can be produced to serve as a cost-effective and reliable source of BChE for prophylaxis and post-exposure treatment. (Source: BMC Biotechnology - Latest articles)

Construction of a series of vectors for high throughput cloning and expression screening of membrane proteins from mycobacterium tuberculosis

BMC Biotechnology - Latest articles — Fri, 16 May 2008 04:00:00 +0100

Background: One of the major challenges for membrane protein structural genomics is establishing high-throughput cloning and expression screening methods to obtain enough purified protein in a homogeneous preparation for structural and functional studies. Here a series of ligation independent cloning based vectors were constructed to address this challenge. Results: The feasibility of these vectors was tested with 41 putative membrane proteins from Mycobacterium tuberculosis. The efficiency for direct cloning of these target genes from PCR products was 95% (39/41). Over 40% of cloned genes were overexpressed in Escherichia coli BL21 (DE3)-RP codon plus strain in the first round of expression screening. For those proteins which showed no expression, three protein fusion partners were prepared and it was found that each of the target proteins could be overexpressed by at least one of these fusions, resulting in the overexpression of two thirds of the cloned genes. Conclusion: This expression platform features high throughput cloning, high flexibility for different constructs, and high efficiency for membrane protein overexpression, and is expected to be useful in membrane protein structural and functional studies. (Source: BMC Biotechnology - Latest articles)

Book review: graphics of large datasets. visualizing a million. by a. unwin, m. theus, and h. hofmann

Biometrical Journal — Fri, 16 May 2008 04:00:00 +0100

No Abstract (Source: Biometrical Journal)

Biothreats workshop to take place in ws

bizjournals.com Health Care:Biotechnology headlines — Thu, 15 May 2008 18:21:07 +0100

Clean Earth Technologies will partner with N.C. State University to put on the first annual Biothreat Agents (Bacillus) Workshop at the Piedmont Triad Research Park on May 28. (Source: bizjournals.com Health Care:Biotechnology headlines)

Stowers researchers find key genetic mutation in spinal defects

bizjournals.com Health Care:Biotechnology headlines — Thu, 15 May 2008 18:16:16 +0100

Researchers at the Stowers Institute for Medical Research have helped identify a genetic mutation that causes congenital vertebral abnormalities in humans. (Source: bizjournals.com Health Care:Biotechnology headlines)

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Duncan family gives $35m to m. d. anderson

bizjournals.com Health Care:Biotechnology headlines — Thu, 15 May 2008 16:20:51 +0100

The Dan L. Duncan Family Foundation has given The University of Texas M.D. Anderson Cancer Center $35 million -- the institution's largest gift to its cancer prevention program and the second-largest gift in its 67-year history. (Source: bizjournals.com Health Care:Biotechnology headlines)

Fate finds new executive chairman in mendlein

bizjournals.com Health Care:Biotechnology headlines — Thu, 15 May 2008 14:41:27 +0100

Less than a year from the sale of his Massachusetts life sciences firm, John Mendlein has been named executive chairman of biotech startup Fate Therapeutics Inc. (Source: bizjournals.com Health Care:Biotechnology headlines)

Lawyer e. stewart jones pledges $150k to ualbany's cancer research center

bizjournals.com Health Care:Biotechnology headlines — Thu, 15 May 2008 13:50:30 +0100

Attorney E. Stewart Jones announced today that he is pledging $150,000 to support the University at Albany's Cancer Research Center. (Source: bizjournals.com Health Care:Biotechnology headlines)

The role of dynamic stimulation pattern in the analysis of bistable intracellular networks.

Biosystems — Thu, 15 May 2008 10:07:11 +0100

The role of dynamic stimulation pattern in the analysis of bistable intracellular networks.

Biosystems. 2008 Jun;92(3):270-81

Authors: Millat T, Sreenath SN, Soebiyanto RP, Avva J, Cho KH, Wolkenhauer O

Bistable systems play an important role in the functioning of living cells. Depending on the strength of the necessary positive feedback one can distinguish between (irreversible) "one-way switch" or (reversible) "toggle-switch" type behavior. Besides the well- established steady-state properties, some important characteristics of bistable systems arise from an analysis of their dynamics. We demonstrate that a supercritical stimulus amplitude is not sufficient to move the system from the lower (off-state) to the higher branch (on-state) for either a step or a pulse input. A switching surface is identified for the system as a function of the initial condition, input pulse amplitude and duration (a supercritical signal). We introduce the concept of bounded autonomy for single level systems with a pulse input. Towards this end, we investigate and characterize the role of the duration of the stimulus. Furthermore we show, that a minimal signal power is also necessary to change the steady state of the bistable system. This limiting signal power is independent of the applied stimulus and is determined only by systems parameters. These results are relevant for the design of experiments, where it is often difficult to create a defined pattern for the stimulus. Furthermore, intracellular processes, like receptor internalization, do manipulate the level of stimulus such that level and duration of the stimulus is conducive to characteristic behavior.

PMID: 18474306 [PubMed - in process]

(Source: Biosystems)

Coherently controlled ballistic charge currents injected in single-walled carbon nanotubes and graphite.

Nano Letters — Thu, 15 May 2008 04:00:00 +0100

Coherently Controlled Ballistic Charge Currents Injected in Single-Walled Carbon Nanotubes and Graphite.

Nano Lett. 2008 May 15;

Authors: Newson RW, Ménard JM, Sames C, Betz M, Driel HM

Ballistic electrical currents are optically injected into aligned single-walled carbon nanotubes and bulk graphite at 300 K via quantum interference between single and two photon absorption of phase-related 700 and 1400 nm, 150 fs pulses. The transient currents are detected via the emitted terahertz radiation. Optical phase and power dependence are consistent with the quantum interference optical process. Under similar excitation conditions, the peak current for a forest of nanotubes, with a diameter distribution of approximately 2.5 +/- 1.5 nm, is 9 +/- 1 times larger than that in graphite. At peak focused intensities of 10 GW cm (-2) (1400 nm) and 0.15 GW cm (-2) (700 nm), the peak current is approximately 1 nA per nanotube. The peak current for pump light polarized along the tubes is approximately 3.5 times higher than that for light polarized perpendicular to the tubes.

PMID: 18479170 [PubMed - as supplied by publisher]

(Source: Nano Letters)

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Residual pattern based test for interactions in two-way anova

Biometrical Journal — Thu, 15 May 2008 04:00:00 +0100

This article proposes a new test to detect interactions in replicated two-way ANOVA models, more powerful than the classical F -test and more general than the test of Terbeck and Davies (1998, Annals of Statistics 26, 1279-1305) developed for the case with unconditionally identifiable interaction pattern. We use the parameterization without the conventional restrictions on the interaction terms and base our test on the maximum of the standardized disturbance estimates. We show that our test is unbiased and consistent, and discuss how to estimate the p -value of the test. In a 3 × 3 case, which is our main focus in this article, the exact p -value can be computed by using four-dimensional integrations. For a general I × J case which requires an (I - 1) × (J - 1) dimensional integration for a numerical evaluation of the exact p -value, we propose to use an improved Bonferroni inequality to estimate an upperbound of the p -value and simulations indicate a reasonable accuracy of the upperbound. Via simulations, we show that our test is more powerful than the classical F -test and also that it can deal with both situations: unconditionally identifiable and non-unconditionally identifiable cases. An application to genetic data is presented in which the new test is significant, while the classical F -test failed to detect interactions. (© 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) (Source: Biometrical Journal)

Simultaneous inference in general parametric models

Biometrical Journal — Thu, 15 May 2008 04:00:00 +0100

Simultaneous inference is a common problem in many areas of application. If multiple null hypotheses are tested simultaneously, the probability of rejecting erroneously at least one of them increases beyond the pre-specified significance level. Simultaneous inference procedures have to be used which adjust for multiplicity and thus control the overall type I error rate. In this paper we describe simultaneous inference procedures in general parametric models, where the experimental questions are specified through a linear combination of elemental model parameters. The framework described here is quite general and extends the canonical theory of multiple comparison procedures in ANOVA models to linear regression problems, generalized linear models, linear mixed effects models, the Cox model, robust linear models, etc. Several examples using a variety of different statistical models illustrate the breadth of the results. For the analyses we use the R add-on package multcomp, which provides a convenient interface to the general approach adopted here. (© 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) (Source: Biometrical Journal)

Book review: angewandte statistik 1. by m. precht, r. kraft und m. bachmaier

Biometrical Journal — Thu, 15 May 2008 04:00:00 +0100

No Abstract (Source: Biometrical Journal)

Book review: practical guide to clinical data management. by s. prokscha

Biometrical Journal — Thu, 15 May 2008 04:00:00 +0100

No Abstract (Source: Biometrical Journal)

Barshop institute director recognized nationally for aging research

bizjournals.com Health Care:Biotechnology headlines — Wed, 14 May 2008 18:50:28 +0100

The director of the Sam and Ann Barshop Institute for Longevity and Aging Studies at the University of Texas Health Science Center at San Antonio has won a national honor from the American Federation for Aging Research. (Source: bizjournals.com Health Care:Biotechnology headlines)

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Proventys raises $5.65m, hires ceo, strikes mckesson deal

bizjournals.com Health Care:Biotechnology headlines — Wed, 14 May 2008 18:17:47 +0100

Personalized medicine company Proventys said Wednesday that it has closed on a $5.65 million round of venture financing, hired a new CEO and reached a deal with health-care giant McKesson. (MCK) (Source: bizjournals.com Health Care:Biotechnology headlines)

Dose finding for continuous and ordinal outcomes with a monotone objective function: a unified approach

Biometrics — Wed, 14 May 2008 18:08:42 +0100

Biometrics, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Summary. In many phase I trials, the design goal is to find the dose associated with a certain target toxicity rate. In some trials, the goal can be to find the dose with a certain weighted sum of rates of various toxicity grades. For others, the goal ... (Source: Biometrics)

Three leaders to be inducted into tech valley business hall of fame

bizjournals.com Health Care:Biotechnology headlines — Wed, 14 May 2008 15:56:28 +0100

Three business leaders are being inducted into the Tech Valley Business Hall of Fame on Thursday. (Source: bizjournals.com Health Care:Biotechnology headlines)

Ku hospital board supports cancer partners' name

bizjournals.com Health Care:Biotechnology headlines — Wed, 14 May 2008 14:55:17 +0100

The University of Kansas Hospital's board of directors passed a resolution supporting a new name for an advisory board that will guide the region's cancer initiative. (Source: bizjournals.com Health Care:Biotechnology headlines)

Boston scientific gets fda ok for new heart implants

bizjournals.com Health Care:Biotechnology headlines — Wed, 14 May 2008 14:54:44 +0100

Officials at Boston Scientific Corp. report that the U.S. Food and Drug Administration has granted the medical devices giant approvals for two new cardiac implants. (BSX) (Source: bizjournals.com Health Care:Biotechnology headlines)

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Una ryan steps down as avant ceo

bizjournals.com Health Care:Biotechnology headlines — Wed, 14 May 2008 13:15:32 +0100

Biotech industry veteran Una Ryan is leaving her long-time post as CEO of Needham-based Avant Immunotherapeutics Inc., the company reports. (Source: bizjournals.com Health Care:Biotechnology headlines)

Characterization of healthy skin using near infrared spectroscopy and skin impedance

Medical and Biological Engineering and Computing — Wed, 14 May 2008 06:08:24 +0100

Abstract Near infrared spectroscopy (NIR) and skin impedance (IMP) spectroscopy are two methods suggested for diagnoses of diseases inducing adverse effects in skin. The reproducibility of these methods and their potential value in non-invasive diagnostics were investigated. Measurements were performed in vivo on healthy skin at five anatomic body sites on eight young women. partial least squares discriminant analysis showed that both methods were useful for classification of the skin characteristics at the sites. Inter-individually the NIR model gave 100% correct classification while the IMP model provided 92%. Intra-individually the NIR model gave 88% correct classification whereas the IMP model did not provide any useful classification. The correct classification was increased to 93% when both datasets were combined, which demonstrates the value of adding information. Partial least squares discriminant analysis gave 72% correct predictions of skin sites while the combined model slightly improved to 73%. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s11517-008-0343-xAuthors Ida Bodén, Umeå University Department of Surgical and Perioperative Sciences/Surgery 901 87 Umeå SwedenDavid Nilsson, UmBio AB Box 7978 907 19 Umeå SwedenPeter Naredi, Umeå University Department of Surgical and Perioperative Sciences/Surgery 901 87 Umeå SwedenBritta Lindholm-Sethson, Umeå University Department of Chemistry 901 87 Umeå Sweden Journal Medical and Biological Engineering and ComputingOnline ISSN 1741-0444Print ISSN 0140-0118 (Source: Medical and Biological Engineering and Computing)

Finite difference iterative solvers for electroencephalography: serial and parallel performance analysis

Medical and Biological Engineering and Computing — Wed, 14 May 2008 06:08:24 +0100

Abstract Currently the resolution of the head models used in electroencephalography (EEG) studies is limited by the speed of the forward solver. Here, we present a parallel finite difference technique that can reduce the solution time of the governing Poisson equation for a head model. Multiple processors are used to work on the problem simultaneously in order to speed up the solution and provide the memory for solving large problems. The original computational domain is divided into multiple rectangular partitions. Each partition is then assigned to a processor, which is responsible for all the computations and inter-processor communication associated with the nodes in that particular partition. Since the forward solution time is mainly spent on solving the associated matrix equation, it is desirable to find the optimum matrix solver. A detailed comparison of various iterative solvers was performed for both isotropic and anisotropic realistic head models constructed from MRI images. The conjugate gradient (CG) method preconditioned with an advanced geometric multigrid technique was found to provide the best overall performance. For an anisotropic model with 256 × 128 × 256 cells, this technique provides a speedup of 508 on 32 processors over the serial CG solution, with a speedup of 20.1 and 25.3 through multigrid preconditioning and parallelization, respectively. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s11517-008-0344-9Authors Derek N. Barnes, New Mexico State University Klipsch School of Electrical and Computer Engineering MSC 3-O Las Cruces NM 88003 USAJohn S. George, Los Alamos National Laboratory Biological and Quantum Physics Group MS D454 Los Alamos NM 87545 USAKwong T. Ng, New Mexico State University Klipsch School of Electrical and Computer Engineering MSC 3-O Las Cruces NM 88003 USA Journal Medical and Biological Engineering and ComputingOnline ISSN 1741-0444Print ISSN 0140-0118 (Source: Medical and Biological Engineering and Computing)

Performance of a new protein a affinity membrane for the primary recovery of antibodies

Biotechnology Progress — Tue, 13 May 2008 23:22:38 +0100

Cristiana Boi, Simone Dimartino, and Giulio C. SartiWeb Release Date: Tue, 13 May 2008 00:00:00 EDT (Article) DOI: 10.1021/bp0704743 (Source: Biotechnology Progress)

Model-based geostatistics by gönen, m

Biometrics — Tue, 13 May 2008 23:22:15 +0100

Biometrics, Volume 64, Issue 2, Page 659, June 2008. (Source: Biometrics)

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Discussions

Biometrics — Tue, 13 May 2008 23:22:14 +0100

Biometrics, Volume 64, Issue 2, Page 587-589, June 2008. (Source: Biometrics)

Discussions

Biometrics — Tue, 13 May 2008 23:22:13 +0100

Biometrics, Volume 64, Issue 2, Page 586-587, June 2008. (Source: Biometrics)

Biometric practice

Biometrics — Tue, 13 May 2008 23:21:14 +0100

Biometrics, Volume 64, Issue 2, Page 669, June 2008. P. Bacchetti, C. E. McCulloch, and M. R. Segal 577 Simple, Defensible Sample Sizes Based on Cost Efficiency Il est d'usage de choisir une taille d'échantillon garantissant une puissance de test de 80% ou plus, sans prendre en compte le coût impliqué. ... (Source: Biometrics)

Simple, defensible sample sizes based on cost efficiency

Biometrics — Tue, 13 May 2008 23:21:00 +0100

Biometrics, Volume 64, Issue 2, Page 577-585, June 2008. Summary. The conventional approach of choosing sample size to provide 80% or greater power ignores the cost implications of different sample size choices. Costs, however, are often impossible for investigators and funders to ignore in actual practice. ... (Source: Biometrics)

Data clustering: theory algorithms and applications by gan, g., chaoqun, m. a., and wu, j

Biometrics — Tue, 13 May 2008 23:20:59 +0100

Biometrics, Volume 64, Issue 2, Page 656-657, June 2008. (Source: Biometrics)

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Information criteria and statistical modeling by konishi, s. and kitagawa, g

Biometrics — Tue, 13 May 2008 23:20:48 +0100

Biometrics, Volume 64, Issue 2, Page 661, June 2008. (Source: Biometrics)

Modelling for field biologists and other interesting people by kokko, h

Biometrics — Tue, 13 May 2008 23:20:30 +0100

Biometrics, Volume 64, Issue 2, Page 662, June 2008. (Source: Biometrics)

Discussions

Biometrics — Tue, 13 May 2008 23:20:29 +0100

Biometrics, Volume 64, Issue 2, Page 589-591, June 2008. (Source: Biometrics)

Model-based geostatistics by diggle, p. j. and ribeiro, p. j

Biometrics — Tue, 13 May 2008 23:20:19 +0100

Biometrics, Volume 64, Issue 2, Page 653-654, June 2008. (Source: Biometrics)

Correction to "doubly robust estimation in missing data and causal inference models," by h. bang and j. m. robins; 61, 962–972, december 2005

Biometrics — Tue, 13 May 2008 23:20:19 +0100

Biometrics, Volume 64, Issue 2, Page 650, June 2008. (Source: Biometrics)

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Model-based geostatistics by do, k.-a., müller, p., and vannucci, m

Biometrics — Tue, 13 May 2008 23:20:00 +0100

Biometrics, Volume 64, Issue 2, Page 654-655, June 2008. (Source: Biometrics)

Rejoinder

Biometrics — Tue, 13 May 2008 23:19:14 +0100

Biometrics, Volume 64, Issue 2, Page 592-594, June 2008. (Source: Biometrics)

Applied asymptotics: case studies in small sample statistics by brazzale, a. r., davison, a. c., and reid, n

Biometrics — Tue, 13 May 2008 23:19:13 +0100

Biometrics, Volume 64, Issue 2, Page 660, June 2008. (Source: Biometrics)

Reliability and risk: a bayesian perspective by singpurwalla, n. d

Biometrics — Tue, 13 May 2008 23:19:13 +0100

Biometrics, Volume 64, Issue 2, Page 657-658, June 2008. (Source: Biometrics)