MedWorm: Cancer & Oncology

Electronic Pages Abstract

Oral Oncology — Fri, 20 Nov 2009 13:50:28 +0100

(Source: Oral Oncology)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Editorial Board/Aims & Scope

Oral Oncology — Fri, 20 Nov 2009 13:50:22 +0100

(Source: Oral Oncology)

Morphine Supports Tumor Cell Proliferation and Angiogenesis

OncologySTAT What Patients Are Reading — Fri, 20 Nov 2009 13:50:20 +0100

Morphine and other opiate-based painkillers appear to foster the growth of cancer cells. Two new studies, conducted in cell lines and in mice, add evidence to this previously reported observation. Morphine... (Source: OncologySTAT What Patients Are Reading)

AS feasible for favorable-risk prostate cancer patients

MedWire News - Prostate Cancer — Fri, 20 Nov 2009 13:49:33 +0100

Active surveillance is a feasible treatment option for men with favorable-risk prostate cancer, and for those who are over 70 years old with intermediate-risk disease, say Canadian researchers. (Source: MedWire News - Prostate Cancer)

Lapatinib monotherapy feasible for HER2-positive metastatic breast cancer

MedWire News - Oncology — Fri, 20 Nov 2009 13:49:33 +0100

Lapatinib monotherapy is an effective treatment for patients with human epidermal growth factor receptor 2-positive advanced or metastatic breast cancer that has relapsed after trastuzumab treatment, Japanese research suggests. (Source: MedWire News - Oncology)

Lapatinib monotherapy feasible for HER2-positive metastatic breast cancer

MedWire News - Breast Cancer — Fri, 20 Nov 2009 13:49:33 +0100

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

CAM National Baseline Report

Cancer Plan Newsfeed — Fri, 20 Nov 2009 13:45:21 +0100

The Department of Health has published 'CAM National... (Source: Cancer Plan Newsfeed)

Annual evidence update on lung cancer

Cancer Plan Newsfeed — Fri, 20 Nov 2009 13:45:21 +0100

This is the 5th Annual Evidence Update (AEU) on lung cancer... (Source: Cancer Plan Newsfeed)

Manual for Cancer Services 2008: Children’s Cancer Measures

Cancer Plan Newsfeed — Fri, 20 Nov 2009 13:45:21 +0100

Following a three month consultation period , this is the... (Source: Cancer Plan Newsfeed)

Experts contest review article declaring breast MRI causes more harm than good by encouraging radical Rx

Cancer Network — Fri, 20 Nov 2009 13:30:01 +0100

A review article asserting breast MRI does not improve surgical planning, reduce follow-up surgeries, or reduce the risk of local recurrences drew the ire of the breast imaging community. (Source: Cancer Network)

NICE Appraisal Of Sorafenib For Advanced Hepatocellular Carcinoma

Cancer / Oncology News From Medical News Today — Fri, 20 Nov 2009 10:00:00 +0100

The National Institute for Health and Clinical Excellence (NICE) is currently appraising the use of sorafenib for advanced hepatocellular carcinoma (HCC) in patients for whom surgery or therapies in the region the cancer arose have failed or are not suitable. In its latest draft guidance, published yesterday (19 November 2009), NICE does not recommend sorafenib. (Source: Cancer / Oncology News From Medical News Today)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Esteemed Endorsements Recognize Promising Future Of Breast-Specific Gamma Imaging (BSGI)

Breast Cancer News From Medical News Today — Fri, 20 Nov 2009 10:00:00 +0100

Breast-Specific Gamma Imaging/Molecular Breast Imaging (BSGI/MBI) has been recognized and endorsed by two highly esteemed organizations for the fight against breast cancer: The Society of Breast Imaging (SBI) and the American College of Surgeons. Both societies published articles supporting the further application of this breakthrough imaging technology for the early detection of breast cancer. (Source: Breast Cancer News From Medical News Today)

New Cancer Research Tool: Roche's CIM-Plate 16 Enables Real-Time Analysis Of Cell Migration On The XCELLigence System

Cancer / Oncology News From Medical News Today — Fri, 20 Nov 2009 09:00:00 +0100

Roche Applied Science announces the availability of the new CIM-Plate 16 for their xCELLigence System for cell analysis, for use in cancer research. The 16-well culture plate features electronic sensors for the direct study of cell migration and invasion on the xCELLigence RTCA DP Instrument. (Source: Cancer / Oncology News From Medical News Today)

Alnylam Presents New Pre-clinical Data On ALN-VSP, An RNAi Therapeutic For The Treatment Of Liver Cancer

Cancer / Oncology News From Medical News Today — Fri, 20 Nov 2009 09:00:00 +0100

Alnylam Pharmaceuticals, Inc. (Nasdaq: ALNY), a leading RNAi therapeutics company, announced new pre-clinical data from its ALN-VSP program presented at the AACR-NCI-EORTC Molecular Targets and Cancer Therapeutics International conference being held November 15 - 19, 2009 in Boston, Mass. ALN-VSP is an RNAi therapeutic currently in a Phase I clinical trial for the treatment of liver cancers, including hepatocellular carcinoma (HCC) and other solid tumors with liver involvement. (Source: Cancer / Oncology News From Medical News Today)

Treatment With Folic Acid, Vitamin B12 Associated With Increased Risk Of Cancer, Death

Cancer / Oncology News From Medical News Today — Fri, 20 Nov 2009 09:00:00 +0100

Patients with heart disease in Norway, a country with no fortification of foods with folic acid, had an associated increased risk of cancer and death from any cause if they had received treatment with folic acid and vitamin B12, according to a study in the November 18 issue of JAMA. (Source: Cancer / Oncology News From Medical News Today)

'Chemofog' Takes Toll On Cancer Patients, Australia

Cancer / Oncology News From Medical News Today — Fri, 20 Nov 2009 09:00:00 +0100

A condition that affects the memory and concentration of cancer patients undergoing chemotherapy is sustained in a subgroup of patients, compromising their ability to function and long-term quality of life, according to research presented on wednesday at a major cancer conference. (Source: Cancer / Oncology News From Medical News Today)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

What Is Laryngeal Cancer (Cancer Of The Larynx)? What Causes Laryngeal Cancer?

Cancer / Oncology News From Medical News Today — Fri, 20 Nov 2009 08:00:00 +0100

Laryngeal cancer (cancer of the larynx) is a rare type of cancer. It can cause hoarseness of the voice and swelling of the throat. The larynx, also known as the voice box, is a tube-like structure found at the entrance of the trachea (windpipe). The lump at the front of the throat, commonly known as the Adam's apple, is the larynx. (Source: Cancer / Oncology News From Medical News Today)

New Toxicity Testing Approach Could Make Chemo Drugs Safer

Cancer / Oncology News From Medical News Today — Fri, 20 Nov 2009 08:00:00 +0100

For cancer patients on chemotherapy, the "cure" can be as deadly as the disease itself. Adverse drug reactions are one of the leading causes of death among patients receiving cancer treatment. Jackson Laboratory Professor Gary Churchill wants to change that. With a new two-year, $1 million grant from the National Cancer Institute, Churchill is launching a radical new approach to testing three chemotherapeutic drugs for potential toxic effects. (Source: Cancer / Oncology News From Medical News Today)

Cancers' Sweet Tooth May Be Weakness

Cancer / Oncology News From Medical News Today — Fri, 20 Nov 2009 08:00:00 +0100

The pedal-to-the-metal signals driving the growth of several types of cancer cells lead to a common switch governing the use of glucose, researchers at Winship Cancer Institute of Emory University have discovered. Scientists who study cancer have known for decades that cancer cells tend to consume more glucose, or blood sugar, than healthy cells. (Source: Cancer / Oncology News From Medical News Today)

'Fly Paper' To Capture Circulating Cancer Cells

Cancer / Oncology News From Medical News Today — Fri, 20 Nov 2009 08:00:00 +0100

Just as fly paper captures insects, an innovative new device with nano-sized features developed by researchers at UCLA is able to grab cancer cells in the blood that have broken off from a tumor. These cells, known as circulating tumor cells, or CTCs, can provide critical information for examining and diagnosing cancer metastasis, determining patient prognosis, and monitoring the effectiveness of therapies. (Source: Cancer / Oncology News From Medical News Today)

Exelixis Reports Encouraging Phase 1 Data For The PI3K Inhibitor Xl147 (SAR245408) In Combination With Erlotinib At The AACR-NCI-EORTC Conference

Cancer / Oncology News From Medical News Today — Fri, 20 Nov 2009 07:00:00 +0100

Exelixis, Inc. (Nasdaq:EXEL) reported interim data from an ongoing phase 1 dose-escalation trial of XL147 (SAR245408) in combination with the EGFR inhibitor erlotinib in patients with advanced solid tumors. XL147 is a selective, orally available small molecule inhibitor of phosphoinositide-3-kinase (PI3K). Activation of the PI3K pathway is a frequent event in human tumors, promoting cell proliferation, survival, and resistance to chemotherapy and radiotherapy. (Source: Cancer / Oncology News From Medical News Today)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Genentech And Biogen Idec Receive A Complete Response From The FDA For Rituxan For Chronic Lymphocytic Leukemia

Cancer / Oncology News From Medical News Today — Fri, 20 Nov 2009 04:00:00 +0100

Genentech, Inc., a wholly-owned member of the Roche Group (SIX: RO, ROG; OTCQX: RHHBY), and Biogen Idec (Nasdaq: BIIB) announced today that the U.S. Food and Drug Administration (FDA) issued a complete response on the companies' applications for Rituxan® (rituximab) plus fludarabine and cyclophosphamide (FC) for the treatment of people with previously untreated and previously treated chronic lymphocytic leukemia (CLL). (Source: Cancer / Oncology News From Medical News Today)

Definitive molecular cytogenetic characterization of 15 colorectal cancer cell lines

Genes, Chromosomes and Cancer — Fri, 20 Nov 2009 00:00:00 +0100

In defining the genetic profiles in cancer, cytogenetically aberrant cell lines derived from primary tumors are important tools for the study of carcinogenesis. Here, we present the results of a comprehensive investigation of 15 established colorectal cancer cell lines using spectral karyotyping (SKY), fluorescence in situ hybridization, and comparative genomic hybridization (CGH). Detailed karyotypic analysis by SKY on five of the lines (P53HCT116, T84, NCI-H508, NCI-H716, and SK-CO-1) is described here for the first time. The five lines with karyotypes in the diploid range and that are characterized by defects in DNA mismatch repair had a mean of 4.8 chromosomal abnormalities per line, whereas the 10 aneuploid lines exhibited complex karyotypes and a mean of 30 chromosomal abnormalities....

UK Professor Helps Develop Test To Detect Ovarian Cancer

Cancercompass News: Gynecological Cancer — Fri, 20 Nov 2009 00:00:00 +0100

After four years of research, a new test will help identify cancer in women with ovarian cysts before surgery. Until the OVA1 blood test was created, a precise diagnosis before surgery wasn't possible, said Dr. Frederick R. Ueland, associate professor of gynecologic oncology at the University of Kentucky College of Medicine and a principal investigator on the research project. (Source: Cancercompass News: Gynecological Cancer)

Synta Presents Preclinical Data On Next Generation Hsp90 Inhibitor, STA-9090

Cancercompass News: Colorectal Cancer — Fri, 20 Nov 2009 00:00:00 +0100

Synta Pharmaceuticals Corp, a biopharmaceutical company focused on discovering, developing, and commercializing small molecule drugs to treat severe medical conditions, today announced that preclinical data presented at the AACR-NCI-EORTC Conference on Molecular Targets and Cancer Therapeutics shows that STA-9090, a novel, synthetic inhibitor of heat shock protein 90 (Hsp90), demonstrated strong activity in multiple tumor models. (Source: Cancercompass News: Colorectal Cancer)

Breast Cancer Survivors Disagree With New Mammogram Advice

Cancercompass News: Breast Cancer — Fri, 20 Nov 2009 00:00:00 +0100

After losing her mother to cancer, Shelia Weeks, 61, was advised by her doctor to begin receiving mammograms when she was 36. Her mother's cancer was found in her liver, but started in her breast. There was no widespread detection method such as mammograms at that time. She passed away in 1982. (Source: Cancercompass News: Breast Cancer)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Management of Symptomatic Bone Metastases from Breast Cancer with Concomitant Use of External Radiotherapy and Ibandronate: Results of a Prospective, Pilot Study

The Breast Journal — Fri, 20 Nov 2009 00:00:00 +0100

(Source: The Breast Journal)

In vitro and in vivo evidence that a combination of lapatinib plus S-1 is a promising treatment for pancreatic cancer

Cancer Science — Fri, 20 Nov 2009 00:00:00 +0100

Lapatinib is a small molecule inhibitor of both HER2 and the epidermal growth factor receptor (EGFR). We investigated the effect of treatment with lapatinib alone or in combination with a fluoropyrimidine derivative S-1 against pancreatic cancer. The HER2/EGFR expression in each of the four pancreatic cancer cell lines MiaPaca-2, PANC-1, Capan-1 and Capan-2 was measured by flow cytometry. The anti-tumor effects of lapatinib (30 mg/kg) and/or S-1 (10 mg/kg) were evaluated using female BALB/c nude mice xenografts generated using these four cell lines. Synergy between lapatinib and S-1 was examined by median effect analysis in vitro. Resected pancreatic cancer tissues from 137 patients were immunohistochemically stained with anti-human HER2 and EGFR antibodies. The administration of lapatinib...

The effect of low-level laser irradiation (Ga-Al-AsP - 660nm) on in vitro and in vivo melanoma

BMC Cancer — Fri, 20 Nov 2009 00:00:00 +0100

Conclusions: LLLT Irradiation should be avoided over melanomas as the combination of high irradiance (2.5W/cm2) and high dose (1050J/cm2) significantly increases melanoma tumor growth in vivo. (Source: BMC Cancer)

Editor-in-Chief's Note

Tumor Biology — Thu, 19 Nov 2009 23:00:00 +0100

Tumor Biol 2009;30:I (DOI:10.1159/000260566) (Source: Tumor Biology)

Publisher's Note

Tumor Biology — Thu, 19 Nov 2009 23:00:00 +0100

Tumor Biol 2009;30:II (DOI:10.1159/000260567) (Source: Tumor Biology)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Hepatic Angiomyolipoma with Minimal Intratumoral Fat Content

Karger Publishers — Thu, 19 Nov 2009 23:00:00 +0100

Case Rep Gastroenterol 2009;3:324-331 (DOI:10.1159/000255355) (Source: Karger Publishers)

Extramammary Perianal Paget's Disease

Karger Publishers — Thu, 19 Nov 2009 23:00:00 +0100

Case Rep Gastroenterol 2009;3:332-337 (DOI:10.1159/000256382) (Source: Karger Publishers)

Duodenal Gastrointestinal Stromal Tumor Treated by Wedge Resection in a Patient with Neurofibromatosis Type 1: Report of a Case and Review of the Japanese Literature

Karger Publishers — Thu, 19 Nov 2009 23:00:00 +0100

Case Rep Gastroenterol 2009;3:343-349 (DOI:10.1159/000255019) (Source: Karger Publishers)

Interleukin-1 Gene --511 CT Polymorphism and the Risk of Alzheimer's Disease in a Polish Population

Karger Publishers — Thu, 19 Nov 2009 23:00:00 +0100

Dement Geriatr Cogn Disord 2009;28:461-464 (DOI:10.1159/000259460) (Source: Karger Publishers)

Adult Kasabach-Merritt Syndrome due to Hepatic Giant Hemangioma

Karger Publishers — Thu, 19 Nov 2009 23:00:00 +0100

Case Rep Gastroenterol 2009;3:306-312 (DOI:10.1159/000242420) (Source: Karger Publishers)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Kidney Volume and Albuminuria as Markers of Birth Weight-Blood Pressure Relationship in Essential Hypertension

Karger Publishers — Thu, 19 Nov 2009 23:00:00 +0100

Kidney Blood Press Res 2009;32:399-404 (DOI:10.1159/000260041) (Source: Karger Publishers)

Metabolic Syndrome Components in Patients with Autosomal-Dominant Polycystic Kidney Disease

Karger Publishers — Thu, 19 Nov 2009 23:00:00 +0100

Kidney Blood Press Res 2009;32:405-410 (DOI:10.1159/000260042) (Source: Karger Publishers)

Interleukin-6 Polymorphisms and Gender: Relationship with the Occurrence of Hepatocellular Carcinoma in Patients with End-Stage Liver Disease

Karger Publishers — Thu, 19 Nov 2009 23:00:00 +0100

Oncology 2009;77:304-313 (DOI:10.1159/000260057) (Source: Karger Publishers)

Neuroendocrine Carcinomas Arising in Solid-Organ Transplant Recipients: Rare but Aggressive Malignancies

Karger Publishers — Thu, 19 Nov 2009 23:00:00 +0100

Oncology 2009;77:314-317 (DOI:10.1159/000260058) (Source: Karger Publishers)

Evaluating Major Depressive Episodes through the Algorithmically Structured Systematic Exploration of Subject's State of Mind

Karger Publishers — Thu, 19 Nov 2009 23:00:00 +0100

Psychopathology 2010;43:41-52 (DOI:10.1159/000260043) (Source: Karger Publishers)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Are There Valid Subtypes of Schizophrenia? A Grade of Membership Analysis

Karger Publishers — Thu, 19 Nov 2009 23:00:00 +0100

Psychopathology 2010;43:53-62 (DOI:10.1159/000260044) (Source: Karger Publishers)

Psychiatric Profile in Rubinstein-Taybi Syndrome

Karger Publishers — Thu, 19 Nov 2009 23:00:00 +0100

Psychopathology 2010;43:63-68 (DOI:10.1159/000260045) (Source: Karger Publishers)

Radiation Schedules in Relation to Obliteration and Complications in Hypofractionated Conformal Stereotactic Radiotherapy of Arteriovenous Malformations

Karger Publishers — Thu, 19 Nov 2009 23:00:00 +0100

Stereotact Funct Neurosurg 2010;88:24-28 (DOI:10.1159/000260076) (Source: Karger Publishers)

Construction of Relational Topographies from the Quantitative Measurements of Functional Deep Brain Stimulation Using a 'Roving Window' Interpolation Algorithm

Karger Publishers — Thu, 19 Nov 2009 23:00:00 +0100

Stereotact Funct Neurosurg 2010;88:16-23 (DOI:10.1159/000260075) (Source: Karger Publishers)

Electrocorticographic Frequency Alteration Mapping of Speech Cortex during an Awake Craniotomy: Case Report

Karger Publishers — Thu, 19 Nov 2009 23:00:00 +0100

Stereotact Funct Neurosurg 2010;88:11-15 (DOI:10.1159/000260074) (Source: Karger Publishers)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Stimulation-Induced Dyskinesia in the Early Stage after Subthalamic Deep Brain Stimulation

Karger Publishers — Thu, 19 Nov 2009 23:00:00 +0100

Stereotact Funct Neurosurg 2010;88:29-34 (DOI:10.1159/000260077) (Source: Karger Publishers)

Co-Expression of p53 and Bcl-2 Proteins in Human Papillomavirus-Induced Premalignant Lesions of the Uterine Cervix: Correlation with Progression to Malignancy

Karger Publishers — Thu, 19 Nov 2009 23:00:00 +0100

Tumor Biol 2009;30:276-285 (DOI:10.1159/000259911) (Source: Karger Publishers)

Regulation of Clusterin Expression in Human Cancer via DNA Methylation

Karger Publishers — Thu, 19 Nov 2009 23:00:00 +0100

Tumor Biol 2009;30:286-291 (DOI:10.1159/000259912) (Source: Karger Publishers)

Targeting Vascular Endothelial Growth Factor in Renal Cell Carcinoma

Karger Publishers — Thu, 19 Nov 2009 23:00:00 +0100

Tumor Biol 2009;30:292-299 (DOI:10.1159/000260241) (Source: Karger Publishers)

Harvard Catalyst awards its second round of pilot grants

DF/HCC: Latest News — Thu, 19 Nov 2009 21:47:00 +0100

(Source: DF/HCC: Latest News)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Axel Grothey, MD - Modifying Treatment, Maximizing Benefit: A Case-Based Exploration of Advanced CRC Management

PeerView CME/CE Video Podcast - Oncology — Thu, 19 Nov 2009 18:59:52 +0100

Please be sure to view the accompanying (PDF) file for full CME/CNE/CPE information. (Source: PeerView CME/CE Video Podcast - Oncology)

Axel Grothey, MD - Modifying Treatment, Maximizing Benefit: A Case-Based Exploration of Advanced CRC Management

PeerView CME/CE Audio Podcast - Oncology — Thu, 19 Nov 2009 18:59:52 +0100

Please be sure to view the accompanying (PDF) file for full CME/CNE/CPE information. (Source: PeerView CME/CE Audio Podcast - Oncology)

CME/CNE/CPE - Modifying Treatment, Maximizing Benefit: A Case-Based Exploration of Advanced CRC Management

PeerView CME/CE Video Podcast - Oncology — Thu, 19 Nov 2009 18:59:46 +0100

Please view this PDF file for full CME/CNE/CPE information. You will need Adobe Acrobat reader software to access this file. (Source: PeerView CME/CE Video Podcast - Oncology)

CME/CNE/CPE - Modifying Treatment, Maximizing Benefit: A Case-Based Exploration of Advanced CRC Management

PeerView CME/CE Audio Podcast - Oncology — Thu, 19 Nov 2009 18:59:46 +0100

Please view this PDF file for full CME/CNE/CPE information. You will need Adobe Acrobat reader software to access this file. (Source: PeerView CME/CE Audio Podcast - Oncology)

David X

Stand Up 2 Cancer — Thu, 19 Nov 2009 18:28:42 +0100

At twenty-one, I was diagnosed with brain cancer. I felt some relief at knowing why I had been experiencing fits of insanity and rage, but the whole cancer deal was a bit terrifying. For the first time in my life, I was given the chance to practice what I preached: to smile through the rough times, and to laugh when the river was by all means traveling too swift and deep. read more (Source: Stand Up 2 Cancer)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

The Martinez Family

Stand Up 2 Cancer — Thu, 19 Nov 2009 18:22:14 +0100

The beautiful baby boy they decided to call Alec was already in Vananh’s womb when she and Stephen got married. They would later refer to him as their miracle child; his conception had reunited the couple after a five-year separation. In a new, custom-built home in a quiet suburb of Portland, Stephen and Vananh quickly settled into their life as a newlywed couple, parents to a wonderful, healthy boy. Looking around, they couldn’t help but feel blessed. read more (Source: Stand Up 2 Cancer)

Secretary Sebelius Statement On New Breast Cancer Recommendations

Breast Cancer News From Medical News Today — Thu, 19 Nov 2009 17:00:00 +0100

HHS Secretary Kathleen Sebelius issued the following statement today on new breast cancer screening recommendations from the U.S. Preventive Services Task Force: "There is no question that the U.S. Preventive Services Task Force Recommendations have caused a great deal of confusion and worry among women and their families across this country. I want to address that confusion head on. The U.S. (Source: Breast Cancer News From Medical News Today)

You can cast your vote on health care reform now!

Kidney Cancer Association — Thu, 19 Nov 2009 14:01:54 +0100

Should the Senate pass the $849 billion health care reform package?11/19/2009 (Source: Kidney Cancer Association)

CytRx To Initiate Phase 2 Clinical Trial With INNO-206 In Patients With Advanced Gastric Cancer

Cancer / Oncology News From Medical News Today — Thu, 19 Nov 2009 14:00:00 +0100

CytRx Corporation (NASDAQ: CYTR), a biopharmaceutical company, today announced plans to initiate an open-label, multinational Phase 2 clinical trial with its doxorubicin prodrug INNO-206 as a second-line treatment in patients with advanced gastric (stomach) cancer. CytRx President and CEO Steven A. Kriegsman said, "This planned clinical trial is a key step forward in our plans to build a commercial oncology franchise for CytRx. (Source: Cancer / Oncology News From Medical News Today)

Breast Cancer Campaign: New Breast Cancer Research Funding For Belfast

Breast Cancer News From Medical News Today — Thu, 19 Nov 2009 14:00:00 +0100

Individualised radiotherapy treatment based on a person's genetic make up could soon become a reality, according to Breast Cancer Campaign. Professor Kevin Prise from Queen's University Belfast has been awarded a three year project grant by the charity to study how genes are involved in the effectiveness of radiotherapy treatment for breast cancer. The grant, worth more than Â£160,000, is part of Â£2 million awarded to 20 projects in the UK and Ireland. (Source: Breast Cancer News From Medical News Today)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Some Physicians Say New Breast Cancer Screening Guidelines Unlikely To Alter Their Practices

Breast Cancer News From Medical News Today — Thu, 19 Nov 2009 14:00:00 +0100

One day after the release of new breast cancer screening guidelines, many physicians and some medical groups are saying that they do not plan to adopt the new recommendations -- which represent a drastic change -- the New York Times reports (Belluck, New York Times, 11/18). The guidelines, released by the U.S. (Source: Breast Cancer News From Medical News Today)

Showdown set for 2-thousand page health bill

Kidney Cancer Association — Thu, 19 Nov 2009 13:58:42 +0100

Senate Majority Leader Harry Reid set the stage for a climactic debate in the Senate over health care by unveiling a 10-year, $848 billion bill that would extend insurance to 31 million Americans without coverage. Mr. Reid's proposed legislation, 2,074 pages, is the Senate's answer to a bill that narrowly passed the House Nov. 7. 11/19/2009 (Source: Kidney Cancer Association)

Lymphoproliferative Disorders in Patients Receiving Thiopurines for Inflammatory Bowel Disease: A Prospective Observational Cohort Study

OncologySTAT Journal Scans — Thu, 19 Nov 2009 13:50:50 +0100

Patients receiving thiopurines for inflammatory bowel disease have an increased risk of developing lymphoproliferative disorders. Background: Reports of an increased risk of lymphoproliferative disorders... (Source: OncologySTAT Journal Scans)

Shorter Radiation Course Effective in High-Risk Prostate Cancer

OncologySTAT Latest News — Thu, 19 Nov 2009 13:50:49 +0100

CHICAGO (EGMN) -Delivery of a lower total radiation dose in fewer but more intense fractions improved control of high-risk prostate cancer without increasing toxicity in a multicenter, phase III trial... (Source: OncologySTAT Latest News)

Targeting the Epidermal Growth Factor Receptor in Epithelial Ovarian Cancer: Current Knowledge and Future Challenges

Journal of Oncology — Thu, 19 Nov 2009 13:50:13 +0100

The epidermal growth factor receptor is overexpressed in up to 60% of ovarian epithelial malignancies. EGFR regulates complex cellular events due to the large number of ligands, dimerization partners, and diverse signaling pathways engaged. In ovarian cancer, EGFR activation is associated with increased malignant tumor phenotype and poorer patient outcome. However, unlike some other EGFR-positive solid tumors, treatment of ovarian tumors with anti-EGFR agents has induced minimal response. While the amount of information regarding EGFR-mediated signaling is considerable, current data provides little insight for the lack of efficacy of anti-EGFR agents in ovarian cancer. More comprehensive, systematic, and well-defined approaches are needed to dissect the roles that EGFR plays in the com...

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

A Case Report of Tongue Metastasis from Lung Carcinoma

Chinese Journal of Lung Cancer — Thu, 19 Nov 2009 13:50:07 +0100

(Source: Chinese Journal of Lung Cancer)

Expression of PTEN, p53 and P-glycoprotein in Non-small cell Lung Cancer and Their Predictive Values

Chinese Journal of Lung Cancer — Thu, 19 Nov 2009 13:50:06 +0100

Conclusion To some extent, the expression level of PTEN, p53 and P-gp may predict the effect of radiotherapy, chemotherapy and prognosis of NSCLC. (Source: Chinese Journal of Lung Cancer)

Roles of Volume-sensitive Cl- Channel on Apoptosis and Drug Resistance in Cancer Cells

Chinese Journal of Lung Cancer — Thu, 19 Nov 2009 13:50:06 +0100

(Source: Chinese Journal of Lung Cancer)

Dll4/Notch Signaling Pathway and Tumor Angiogenesis

Chinese Journal of Lung Cancer — Thu, 19 Nov 2009 13:50:06 +0100

(Source: Chinese Journal of Lung Cancer)

Pathogenesis of Molecular Signaling Pathways Changes in Smoking-induced Lung Cancer

Chinese Journal of Lung Cancer — Thu, 19 Nov 2009 13:50:06 +0100

(Source: Chinese Journal of Lung Cancer)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Inflammation -- A Driving Force Speeds Cancer Metastasis

Chinese Journal of Lung Cancer — Thu, 19 Nov 2009 13:50:06 +0100

(Source: Chinese Journal of Lung Cancer)

Updates in Cancer Research: Insights from the AACR 100th Annual Meeting

Chinese Journal of Lung Cancer — Thu, 19 Nov 2009 13:50:06 +0100

(Source: Chinese Journal of Lung Cancer)

The Comparison of Clinical Effect of Rh-endostar on Retreated Non-Small Cell Lung Cancer and Colorectal Cancer

Chinese Journal of Lung Cancer — Thu, 19 Nov 2009 13:50:06 +0100

Conclusion The clinical efficacy of rh-endostatin on retreated colorectal cancer was better than on retreated non-small cell lung cancer, which suggested that it was necessary to perform more clinical observations on the digestive tumors. (Source: Chinese Journal of Lung Cancer)

Comparison of the Clinical Effects of Paclitaxel and Paclitaxel plus Oxaliplatin as the Second-line Treatment of Advanced Non-small Cell Lung Cancer

Chinese Journal of Lung Cancer — Thu, 19 Nov 2009 13:50:06 +0100

Conclusion Singlepaclitaxel administration as the second-lined treatment of advanced NSCLC is tolerable and has the response effect no worse than the combined chemotherapy. (Source: Chinese Journal of Lung Cancer)

Detection of Chemerin and It’s Clinical Significance in Peripheral Blood of Patients with Lung Cancer

Chinese Journal of Lung Cancer — Thu, 19 Nov 2009 13:50:06 +0100

Conclusion Chemerin has the potential to lung cancer diagnosis as a marker. (Source: Chinese Journal of Lung Cancer)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

The Clinical Analysis of 21 Patients with Lymphoepithelioma-like Carcinoma after Operation

Chinese Journal of Lung Cancer — Thu, 19 Nov 2009 13:50:06 +0100

Conclusion Lymphoepitheliomalike carcinoma of the lung is a very rare and unique subtype of large cell carcinomas of the lung, which has a better prognosis with surgical, chemotherapy and radiotherapy. (Source: Chinese Journal of Lung Cancer)

The Role of Postoperative Radiotherapy on Stage N2 Non-small Cell Lung Cancer

Chinese Journal of Lung Cancer — Thu, 19 Nov 2009 13:50:06 +0100

Conclusion PORT can improve overall survival for N2 NSCLC, especially the patients with the factors as follows: tumor size > 3 cm and multiple station N2 can benefit from PORT more or less. (Source: Chinese Journal of Lung Cancer)

Down-regulation of GRP78 Enhances Chemotherapy Sensitivity to VP-16 in Lung Adenocarcinoma

Chinese Journal of Lung Cancer — Thu, 19 Nov 2009 13:50:06 +0100

Conclusion BAPTA-AM is highly effective in the inhibition of GRP78, down-regulation of GRP78 can significantly increase the sensitivity of adenocacinoma lung cancer to VP-16. All these suggest that inhibition of the expression of GRP78 by chemicals such as BAPTA-AM or anti-sense RNA may be a new therapeutic strategies to lung cancer. (Source: Chinese Journal of Lung Cancer)

Comparative Proteomic Analysis of Human Lung Adenocarcinoma Cisplatin-resistant Cell Strain A549/CD

Chinese Journal of Lung Cancer — Thu, 19 Nov 2009 13:50:06 +0100

Conclusion These differentially expressed proteins give some clues to elucidate the mechanism of lung cancer cell resistant of cisplatin, providing the basis of searching for potential target of chemotherapy of lung cancer. (Source: Chinese Journal of Lung Cancer)

Expression and Significance of Nrf2 and Its Target Genes in Pulmonary Adenocarcinoma A549 Cells Resistant to Cisplatin

Chinese Journal of Lung Cancer — Thu, 19 Nov 2009 13:50:05 +0100

Conclusion It proves that the transcription factor Nrf2 and it’s signal pathways are closely related with drug resistance of tumors. Moreover, this provides a new direction to reverse drug resistance and have significance to avoid and overcome drug resistance of tumor. (Source: Chinese Journal of Lung Cancer)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Trichostatin A Induced Bcl-2 Protein Level Decrease Mediated A549/CDDP Cells Apoptosis by Mitochondria Pathway

Chinese Journal of Lung Cancer — Thu, 19 Nov 2009 13:50:05 +0100

Conclusion TSA induce A549/CDDP cell apoptosis by mitochondria pathway. (Source: Chinese Journal of Lung Cancer)

Lobectomy with Bronchoplasty and Reconstruction of Pulmonary Artery by Minitrauma-technique for Lung Cancer

Chinese Journal of Lung Cancer — Thu, 19 Nov 2009 13:50:05 +0100

Conclusion Lobectomy with bronchoplasty and reconstruction of pulmonary artery by minitrauma-technique for lung cancer could finished the same work with the traditional thoracic lateral incision and had less trauma, less pain, less recovery time. (Source: Chinese Journal of Lung Cancer)

The Relationship between Nano-quartz Oxidative Damage and the High Expression of Nuclear Factor NF-κB of Lung Cancer in Xuanwei, Yunnan

Chinese Journal of Lung Cancer — Thu, 19 Nov 2009 13:50:05 +0100

(Source: Chinese Journal of Lung Cancer)

Longer consultations improve patient satisfaction with surgical treatment

MedWire News - Oncology — Thu, 19 Nov 2009 13:49:56 +0100

Most low-income women with breast cancer are extremely satisfied with the treatment they received from their surgeon, study findings indicate. (Source: MedWire News - Oncology)

Radiation Rx prevents melanoma’s invasion of lymph nodes

Cancer Network — Thu, 19 Nov 2009 13:30:02 +0100

CHICAGO—Radiation of the lymph nodes of high-risk melanoma patients appears to significantly reduce the risk that cancer will recur in those nodes, researchers said at ASTRO 2009. The study was deemed practice-changing, representing the first advance in the management of melanoma in nearly two decades. (Source: Cancer Network)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Tempest Over New Mammography Guidelines Affect Health Legislation, Insurance Coverage

Breast Cancer News From Medical News Today — Thu, 19 Nov 2009 13:00:00 +0100

Newspapers across the country featured front-page follow-up stories on new mammogram recommendations today.The U.S. Preventive Services Task Force -- "which recommended that women in their 40s should no longer get annual mammograms to screen for breast cancer -- sparked an outcry from those who say that the federal government is more interested in saving money than in improving women's health, even though the panel did not consider costs in its analysis," the (Source: Breast Cancer News From Medical News Today)

CIRM Awards Two $19 Million Grants for Brain Tumor Research

National Brain Tumor Society — Thu, 19 Nov 2009 12:45:00 +0100

Of the 14 research teams to receive 4-year grants expected to result in clinical trials, two focus on brain tumor research. (Source: National Brain Tumor Society)

Senate introduces health care bill that requires insurance coverage

HemOncToday.com — Thu, 19 Nov 2009 12:01:00 +0100

(Source: HemOncToday.com)

Making the most of gastric imaging requires clear communication between oncologists and radiologist

Cancer Network — Thu, 19 Nov 2009 12:00:00 +0100

There is a complex array of tests for imaging the abdomen, but there are really only three things that oncologists need to tell radiologists in order to get the most from these imaging studies, according to Fergus V. Coakley, MD, chief of abdominal imaging (Source: Cancer Network)

People Looking For Information On Cancer Say Variety Is Key, UK

Cancer / Oncology News From Medical News Today — Thu, 19 Nov 2009 10:00:00 +0100

PEOPLE looking for detailed information about cancer outside of hospitals need a range of different information sources, reveals a Cancer Research UK survey published in the November issue of Cancer Nursing Practice*. Cancer Research UK's information nurse team used data from 300 telephone and email user satisfaction surveys** to examine why and how Cancer Research UK's Information Services*** were being used. (Source: Cancer / Oncology News From Medical News Today)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

US Mammogram Policy Will Not Change Says Health Secretary

Breast Cancer News From Medical News Today — Thu, 19 Nov 2009 10:00:00 +0100

US secretary for Health and Human Services (HHS) has issued a statement saying that the government policy on what age routine screening mammograms should begin has not changed, following a recent task force recommendation that routine screening mammograms should start at age 50 and not age 40. (Source: Breast Cancer News From Medical News Today)

Media Coverage Of New Mammography Guidelines Confusing To Some, Says Expert

Breast Cancer News From Medical News Today — Thu, 19 Nov 2009 10:00:00 +0100

The public may have problems this week sorting through news articles about a government task force's opposition to routine mammograms for women under 50 and articles about breast cancer survivors touting the benefits of early mammograms. But to properly interpret the news, the public must learn to balance the research with the anecdotal evidence says University of Alabama at Birmingham (UAB) Associate Professor of English Cynthia Ryan, Ph.D. (Source: Breast Cancer News From Medical News Today)

ASCO issues specific recommendations for chemotherapy in stage IV NSCLC

HemOncToday.com — Thu, 19 Nov 2009 09:22:00 +0100

(Source: HemOncToday.com)

Epoetin alfa had no effect on survival, tumor outcomes in head and neck cancers

HemOncToday.com — Thu, 19 Nov 2009 09:04:00 +0100

(Source: HemOncToday.com)

NeoPharm Presents The Phase I Data For Patients With Metastatic Solid Tumors

Cancer / Oncology News From Medical News Today — Thu, 19 Nov 2009 09:00:00 +0100

NeoPharm, Inc. (Other OTC: NEOL.PK) announced the results of a Phase I clinical trial of Liposome Encapsulated Docetaxel (LE-DT) an active component of Taxotere® at a joint International Conference of the American Association for Cancer Research (AACR), the National Cancer Institute (NCI) and the European Organization for Research and Treatment of Cancer (EORTC) being held in Boston, MA. (Source: Cancer / Oncology News From Medical News Today)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Family Caregivers, Simple Touch Techniques Reduce Symptoms In Cancer Patients

Cancer / Oncology News From Medical News Today — Thu, 19 Nov 2009 08:00:00 +0100

Family caregivers can significantly reduce suffering in cancer patients at home through use of simple touch and massage techniques. These findings were recently reported at the 6th International Conference of the Society for Integrative Oncology. The study, sponsored by the National Cancer Institute, evaluated outcomes of a 78 minute DVD instructional program and illustrated manual in a sample of 97 patients and their caregivers. (Source: Cancer / Oncology News From Medical News Today)

What Is Bone Cancer (Sarcoma)? What Causes Bone Cancer?

Cancer / Oncology News From Medical News Today — Thu, 19 Nov 2009 08:00:00 +0100

Bone cancer is an uncommon cancer that begins in a bone. It can originate in any bone in the body, but the long bones that make up the arms and legs are most commonly affected. Several types of bone cancer exist. Some types of bone cancer occur primarily in children, while others affect mostly adults. Primary bone cancer is cancer that starts in the bone. (Source: Cancer / Oncology News From Medical News Today)

Great American Smokeout '09: Time to Quit

MedicineNet Cancer General — Thu, 19 Nov 2009 07:00:00 +0100

Title: Great American Smokeout '09: Time to QuitCategory: Health NewsCreated: 11/19/2009 8:10:00 AMLast Editorial Review: 11/19/2009 (Source: MedicineNet Cancer General)

Morphine May Help Tumors Spread in Cancer Patients

MedicineNet Cancer General — Thu, 19 Nov 2009 07:00:00 +0100

Title: Morphine May Help Tumors Spread in Cancer PatientsCategory: Health NewsCreated: 11/18/2009 12:10:00 PMLast Editorial Review: 11/19/2009 (Source: MedicineNet Cancer General)

Laser therapy can aggravate skin cancer

EurekAlert! - Cancer — Thu, 19 Nov 2009 05:00:00 +0100

(BioMed Central) High irradiances of low-level laser therapy should not be used over melanomas. Researchers writing in the open-access journal BMC Cancer studied the pain relieving, anti-inflammatory "cold laser," finding that it caused increased tumor growth in a mouse model of skin cancer. (Source: EurekAlert! - Cancer)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

ImmunoGen, Inc. Announces Encouraging Clinical Data With Its IMGN901 Compound In The Treatment Of Merkel Cell Carcinoma

Cancer / Oncology News From Medical News Today — Thu, 19 Nov 2009 05:00:00 +0100

ImmunoGen, Inc. (Nasdaq: IMGN), a biopharmaceutical company that develops targeted anticancer therapeutics, today reported encouraging clinical data with its IMGN901 product candidate in the treatment of Merkel cell carcinoma (MCC). Meaningful evidence of anticancer activity has been noted among the limited number of patients with MCC who have received IMGN901. (Source: Cancer / Oncology News From Medical News Today)

Susan G. Komen For The Cure(R) Recommends No Impediments To Breast Cancer Screening

Breast Cancer News From Medical News Today — Thu, 19 Nov 2009 02:00:00 +0100

Susan G. Komen for the Cure®, the world's leading breast cancer advocacy organization, has carefully reviewed the data and new recommendations from the U.S. Preventive Services Task Force (USPSTF) concerning mammography screening. Komen for the Cure issued the following statement today from Eric P. Winer, M.D., chief scientific advisor and chair of Komen's Scientific Advisory Board. "Susan G. (Source: Breast Cancer News From Medical News Today)

TURP useful for excluding prostate cancer after negative biopsy

MedWire News - Prostate Cancer — Thu, 19 Nov 2009 00:00:00 +0100

Men with repeated negative biopsy results but persistent indications of prostate cancer may best have the disease ruled out by transurethral resection of the prostate, report Italian researchers. (Source: MedWire News - Prostate Cancer)

TURP useful for excluding prostate cancer after negative biopsy

MedWire News - Oncology — Thu, 19 Nov 2009 00:00:00 +0100

AS feasible for favorable-risk prostate cancer patients

MedWire News - Oncology — Thu, 19 Nov 2009 00:00:00 +0100

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Oocyte retrieval does not delay adjuvant chemotherapy

MedWire News - Oncology — Thu, 19 Nov 2009 00:00:00 +0100

Procedures to safeguard the fertility of young women with breast cancer do not significantly delay the start of adjuvant chemotherapy, US researchers report. (Source: MedWire News - Oncology)

Oocyte retrieval does not delay adjuvant chemotherapy

MedWire News - Breast Cancer — Thu, 19 Nov 2009 00:00:00 +0100

Procedures to safeguard the fertility of young women with breast cancer do not significantly delay the start of adjuvant chemotherapy, US researchers report. (Source: MedWire News - Breast Cancer)

Transcriptomic analysis of pathways regulated by toll-like receptor 4 in a murine model of chronic pulmonary inflammation and carcinogenesis

Molecular Cancer — Thu, 19 Nov 2009 00:00:00 +0100

Conclusion: This transcriptomic study determined the protective effect of TLR4 in lung carcinogenesis inhibition of multiple pathways including EGFR (e.g. Ereg), inflammatory response genes (e.g. Cxcl5), chemotaxis (e.g. Ccr1) and other cell proliferation genes (e.g. Arg1, Pthlh). Future studies will determine the utility of these pathways as indicators of immune system deficiencies and tumorigenesis. (Source: Molecular Cancer)

iNOS activity is necessary for the cytotoxic and immunogenic effects of doxorubicin in human colon cancer cells

Molecular Cancer — Thu, 19 Nov 2009 00:00:00 +0100

Conclusions: Our data suggest that chemo- and immuno-resistance to anthracyclines are associated in colon cancer cells and rely on a common mechanism, that is the inability of doxorubicin to induce iNOS. Therefore NO donors might represent a promising strategy to restore both chemosensitivity and immunosensitivity to doxorubicin in resistant cells. (Source: Molecular Cancer)

Review: Personalised cancer therapy with selective kinase inhibitors

NeLM - Oncology — Thu, 19 Nov 2009 00:00:00 +0100

Source: J Clin Oncol Area: News In this review, the authors summarise recent developments in personalised cancer therapy with selective kinase inhibitors under the following headings: . Genomic heterogeneity in cancer and the response to drug therapy . Targeting kinases in cancer therapy . Mutationally activated kinases and the clinical response to kinase-targeted therapeutics . Genotype-directed kinase inhibition: the case of epidermal growth factor receptor mutations in lung cancer . Expanding the domain of genotype-associated response to kinase-directed therapies . Preclinical findings suggest a broad role for drug-sensitising alleles of oncogenic kinases . Low-frequency drug...

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

FNCLCC-PACS 04 trial of trastuzumab for patients with axillary-node-positive breast cancer finds no benefit in adjuvant setting

NeLM - Oncology — Thu, 19 Nov 2009 00:00:00 +0100

Source: J Clin Oncol Area: News The PACS04 trial initiated in 2001 aimed to evaluate the efficacy of concomitant use of docetaxel with anthracyclines, and the efficacy of trastuzumab given for 1 year after the end of adjuvant chemotherapy in patients with axillary node-positive breast cancer. In this paper, results of the second randomisation (i.e. evaluation of trastuzumab efficacy in the adjuvant setting in human epidermal growth factor receptor 2 (HER2)-positive patients -FNCLCC-PACS 04 trial) are reported. The initial study involved 3010 patients with operable node-positive breast cancer who were randomised to receive adjuvant anthracycline-based chemotherapy with or without docetaxel. Those who presented HER2-overexpressing tumours (n= 528) were secondarily randomised to e...

Anti-TNF drugs do not seem to increase medium-term cancer risk in rheumatoid arthritis patients

NeLM - Oncology — Thu, 19 Nov 2009 00:00:00 +0100

Source: Arthr Rheum Area: News Over a period of at least six years, treatment of rheumatoid arthritis (RA) with drugs inhibiting tumour necrosis factor -alpha (anti-TNF drugs) does not seem to raise the risk of cancer, according to a population-based observational study. Patients with RA may be at modestly increased risk of cancer, and there is some concern that the anti-TNF drugs may further increase the risk; however clinical trials are not long enough to detect whether this is so in practice. Observational studies are necessary to identify such risks, and this paper reports such a study using the population of Sweden. The authors used three national registries to identify most, if not all, patients diagnosed with RA in Sweden since 1998; they then compared the incidence of c...

NICE issues negative Final Appraisal Determination on sorafenib (first line) for advanced and metastatic hepatocellular carcinoma

NeLM - Oncology — Thu, 19 Nov 2009 00:00:00 +0100

Source: NICE Area: News In its Final Appraisal Determination, NICE has not recommended the use of sorafenib (first line) for the treatment of advanced and metastatic hepatocellular carcinoma in patients for whom surgical or locoregional therapies have failed or are not suitable, as it was not considered a cost-effective use of NHS resources. The appeal period for this appraisal will close on 3rd December 2009. (Source: NeLM - Oncology)

AQUA Technology Recognized As Promising New Strategy For Hormone Receptor Testing In Breast Cancer By NCCN Task Force

Cancercompass News: Breast Cancer — Thu, 19 Nov 2009 00:00:00 +0100

HistoRx today announced that the Company's proprietary AQUA technology, an automated image analysis platform based on tissue-based quantitative immunofluorescence, was noted in a recent National Comprehensive Cancer Network (NCCN) Task Force Report on hormone receptor testing in breast cancer as one of the promising new strategies being developed for the measurement of ER and PgR in breast cancer tissue. (Source: Cancercompass News: Breast Cancer)

Radiation Breakthrough Gives Breast Cancer Patients Hope in Single Dose

Cancercompass News: Breast Cancer — Thu, 19 Nov 2009 00:00:00 +0100

A radiation breakthrough to treat breast cancer patients in one day, as opposed to the current average of six weeks, has arrived at Cancer Treatment Centers of America(R) (CTCA) in Philadelphia. CTCA will become the first in the country to offer this treatment option using the Novac7 technology from Rome, Italy. (Source: Cancercompass News: Breast Cancer)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Myoid Hamartoma of the Breast: A Very Rare Entity

The Breast Journal — Thu, 19 Nov 2009 00:00:00 +0100

(Source: The Breast Journal)

Does the Patient's Opinion Differ From the Clinicians' Regarding Breast Cosmesis after BCT?

The Breast Journal — Thu, 19 Nov 2009 00:00:00 +0100

(Source: The Breast Journal)

Obesity Increases the Risk of Postmenopausal Breast Cancer and is Associated with More Advanced Stage at Presentation But no Impact on Survival

The Breast Journal — Thu, 19 Nov 2009 00:00:00 +0100

(Source: The Breast Journal)

Estrogen Deprivation Therapy and Colon Cancer Risk in Breast Cancer Patients

The Breast Journal — Thu, 19 Nov 2009 00:00:00 +0100

(Source: The Breast Journal)

Clinical Implications of Subcategorizing BI-RADS 4 Breast Lesions associated with Microcalcification: A Radiology–Pathology Correlation Study

The Breast Journal — Thu, 19 Nov 2009 00:00:00 +0100

Abstract: Currently radiologists have the option of subcategorizing BI-RADS 4 breast lesions into 4A (low suspicion for malignancy), 4B (intermediate suspicion of malignancy), and 4C (moderate concern, but not classic for malignancy). To determine the clinical significance of BI-RADS 4 subcategories and the common pathologic changes associated with these mammographic lesions, a retrospective review of 239 consecutive stereotactic-needle core biopsies (SNCB) for microcalcifications was performed. All 239 SNCBs were BI-RADS 4 lesions, and of these, 191 were subcategorized to 4A, 4B or 4C. Ninety-four of 191 (49%) were 4A, 73 (38%) were 4B, and 24 (13%) were 4C. Fibrocystic change was the most common finding (66/239; 28%) followed by ductal carcinoma in situ (DCIS) accounting for 23% of cases...

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Early Response to Neo-adjuvant Chemotherapy in Carcinoma of the Breast Predicts Both Successful Breast-Conserving Surgery and Decreased Risk of Ipsilateral Breast Tumor Recurrence

The Breast Journal — Thu, 19 Nov 2009 00:00:00 +0100

In conclusion, the early response to neo-adjuvant chemotherapy may be a useful predictor of both selection of surgical method and IBTR risk. (Source: The Breast Journal)

Discontinuation of Radiation Treatment among Medicaid-Enrolled Women with Local and Regional Stage Breast Cancer

The Breast Journal — Thu, 19 Nov 2009 00:00:00 +0100

Abstract: For women with nonmetastatic breast cancer, radiation therapy is recommended as a necessary component of the breast conserving surgery (BCS) treatment option. The degree to which Medicaid-enrolled women complete recommended radiation therapy protocols is not known. We evaluate radiation treatment completion rates for Medicaid enrollees aged 18[ndash]64 diagnosed with breast cancer. We determine clinical and socio-demographic factors associated with not starting treatment, and with interruptions or not completing radiation treatment. Using data from the Washington State Cancer Registry linked to Medicaid enrollment and claims records, we identified Medicaid enrollees diagnosed with breast cancer from 1997 to 2003 who received BCS. Among the 402 women who met inclusion criteria, 10...

Breast Reconstruction with Implants, Tissue Expanders and AlloDerm: Predicting Volume and Maximizing the Skin Envelope in Skin Sparing Mastectomies

The Breast Journal — Thu, 19 Nov 2009 00:00:00 +0100

Abstract: AlloDerm has been used as a tissue supplement in conjunction with the pectoralis major muscle to provide full coverage over an implant in breast reconstruction. While this method of reconstruction has shown promising results there is little known on the relationship of AlloDerm size and potential immediate expansion volume. A retrospective chart review was completed evaluating all tissue expander or primary implant reconstructions using AlloDerm. Data recorded included: The type/size of implant/expander, dimensions of the AlloDerm used, initial fill volume, number of expansions and time period of expansion. Statistical analysis was completed with a linear regression model. AlloDerm was used on 49 patients (72 reconstructions). Thirty-four patients (50 reconstructions) underwent r...

Initial activation of EpCAM cleavage via cell-to-cell contact

BMC Cancer — Thu, 19 Nov 2009 00:00:00 +0100

Conclusions: Activation of EpCAM's cleavage and oncogenic capacity is dependent on cellular interaction (juxtacrine) to provide for initial signals of regulated intramembrane proteolysis, which then support signalling via soluble EpEX (paracrine). (Source: BMC Cancer)

Investigation into the controversial association of Streptococcus gallolyticus with colorectal cancer and adenoma

BMC Cancer — Thu, 19 Nov 2009 00:00:00 +0100

Conclusions: S. gallolyticus most likely plays an essential role in the oncogenic progression of normal colorectal mucosa to adenoma and to CRC. This promoting/propagating role of S. gallolyticus might take place by utilizing certain inflammatory, anti-apoptotic, and angiogenic factors of transformation including NF-kappaB and IL-8. (Source: BMC Cancer)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Secondhand Smoke Lung Cancer

About.com Lung Cancer — Thu, 19 Nov 2009 00:00:00 +0100

The link is now well established between secondhand smoke and lung cancer. What are the statistics about secondhand smoke and lung cancer, and how can you protect yourself? (Source: About.com Lung Cancer)

SPECT/CT for preoperative sentinel node localization

Journal of Surgical Oncology — Thu, 19 Nov 2009 00:00:00 +0100

The value of SPECT/CT for detection and localization of sentinel nodes is reviewed. SPECT/CT depicts extra sentinel nodes and identifies non-nodal tracer accumulation. SPECT/CT is indicated in patients with complex lymphatic drainage as often present in patients with head, neck and scapular melanoma, breast cancer patients with extra-axillary sentinel nodes and patients with tumors draining to pelvic nodes. SPECT/CT also clarifies the drainage pattern of inconclusive conventional images (non-visualization or unclear location of the nodes). J. Surg. Oncol. © 2009 Wiley-Liss, Inc. (Source: Journal of Surgical Oncology)

A blood-based biomarker panel for stratifying current risk for colorectal cancer

International Journal of Cancer — Thu, 19 Nov 2009 00:00:00 +0100

Colorectal cancer (CRC) is often curable and preventable using current screening modalities. Unfortunately, screening compliance remains low, partly due to patient dissatisfaction with faecal/endoscopic testing. Recent guidelines advise CRC screening should begin with risk stratification. A blood-based test providing clinically actionable CRC risk information would likely improve screening compliance and enhance clinical decision making. We analyzed 196 gene expression profiles to select candidate CRC biomarkers. qRT-PCR was performed on 642 samples to develop a 7-gene biomarker panel using 112 CRC/120 controls (training set) and 202 CRC/208 controls (independent, blind test set). Panel performance characteristics and disease prevalence (0.7%) were then used to develop a scale assessing an...

Large intragenic deletions of the NF2 gene: Breakpoints and associated phenotypes

Genes, Chromosomes and Cancer — Thu, 19 Nov 2009 00:00:00 +0100

In this study, the breakpoints of six large intragenic deletions in the NF2 gene are determined, which had initially been detected by multiplex ligation-dependent probe amplification. While one breakpoint occurred within an exon, the remaining 11 lied in the corresponding flanking introns. Two of the deletions were most likely caused by nonallelic homologous recombination between Alu sequences, while the other four appeared to be the result of nonhomologous endjoining, possibly facilitated by rearrangement-promoting elements at the junctions in some cases. The clinical features of patients with large intragenic deletions and individuals with mutations affecting single or multiple nucleotides of the NF2 gene are relatively similar. However, patients with deletions of the 3[prime] exons 15 a...

Chemotherapy intensity and toxicity among black and white women with advanced and recurrent endometrial cancer

Cancer — Thu, 19 Nov 2009 00:00:00 +0100

The purpose of this study was to confirm whether black and white women with endometrial cancer are equally tolerant of chemotherapy and identify factors that impact survival.A retrospective review of 169 black women and 982 white women with the International Federation of Gynecologists and Obstetricians stage III, stage IV, or recurrent endometrial carcinoma was performed. All patients received doxorubicin combined with cisplatin. Chemotherapy parameters that were reviewed included relative dose, relative time, and relative dose intensity. Treatment cycles [ge]7 were defined as treatment completion.Although black patients were more likely to experience grades 3-4 anemia (20% vs 14%) and genitourinary (5% vs 1%) toxicity, and less likely to experience severe gastrointestinal toxicity (10% v...

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Yondelis 0.25mg, 0.5mg powder for infusion (trabectedin) - Change to therapeutic indication

NeLM - Oncology — Thu, 19 Nov 2009 00:00:00 +0100

Source: eMC (electronic Medicines Compendium) Area: Other Library Updates > SPC Changes Revised SPC includes changes to: Section 4.1 (Therapeutic indications) Yondelis in combination with pegylated liposomal doxorubicin (PLD) is indicated for the treatment of patients with relapsed platinum-sensitive ovarian cancer. Section 4.2 (Posology and method of administration) For the treatment of ovarian cancer Yondelis is administered every three weeks as a 3-hour infusion at a dose of 1.1 mg/m2, immediately after PLD 30 mg/m2. To minimize the risk of PLD infusion reactions, the initial dose is administered at a rate no greater than 1 mg/minute. If no infusion reaction is observed, subsequent PLD infusions may be administered over a 1-hour period. (See also PLD Summary Product Characte...

Breast Cancer: Search of Hidden Culprits

The Breast Journal — Thu, 19 Nov 2009 00:00:00 +0100

(Source: The Breast Journal)

Influence of GSTP1 I105V polymorphism on cumulative neuropathy and outcome of FOLFOX-4 treatment in Asian patients with colorectal carcinoma

Cancer Science — Thu, 19 Nov 2009 00:00:00 +0100

Glutathione S-transferase P1 (GSTP1) participates in detoxification of potentially genotoxic compounds that may alter the efficacy and toxicity of platinum-based chemotherapy. We analyzed the influence of I105V polymorphism of GSTP1 on clinico-pathological features and outcomes in 166 Chinese patients with metastatic colorectal carcinoma who had been treated with first-line FOLFOX-4. Combined analysis of GSTP1 I105V, ERCC1-118, and XPD-751 polymorphisms was also conducted. The results showed that, in comparison with Caucasian populations, a remarkably lower prevalence of Val105 allele variants was noted (24.7%). Patients with Val105 allele variants had a higher response to FOLFOX-4 (56.1%vs 37.6%, P = 0.04), and a longer progression-free (P < 0.01) as well as overall (P < 0.01) survival. B...

Call for Clarity in the Reporting of Benefit Associated With Anticancer Therapies [CORRESPONDENCE]

Journal of Clinical Oncology — Wed, 18 Nov 2009 23:02:38 +0100

(Source: Journal of Clinical Oncology)

Consensus Report of the National Cancer Institute Clinical Trials Planning Meeting on Pancreas Cancer Treatment [SPECIAL ARTICLE]

Journal of Clinical Oncology — Wed, 18 Nov 2009 23:02:37 +0100

Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer mortality, despite significant improvements in diagnostic imaging and operative mortality rates. The 5-year survival rate remains less than 5% because of microscopic or gross metastatic disease at time of diagnosis. The Clinical Trials Planning Meeting in pancreatic cancer was convened by the National Cancer Institute's Gastrointestinal Cancer Steering Committee to discuss the integration of basic and clinical knowledge in the design of clinical trials in PDAC. Major emphasis was placed on the enhancement of research to identify and validate the relevant targets and molecular pathways in PDAC, cancer stem cells, and the microenvironment. Emphasis was also placed on developing rational combinations of targeted age...

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Personalized Cancer Therapy With Selective Kinase Inhibitors: An Emerging Paradigm in Medical Oncology [BIOLOGY OF NEOPLASIA]

Journal of Clinical Oncology — Wed, 18 Nov 2009 23:02:37 +0100

Selective kinase inhibitors have emerged as an important class of anticancer agents, with demonstrated clinical efficacy and generally favorable toxicity profiles in several common disease settings where conventional treatments have previously provided only modest benefit. Consequently, a substantial effort is now underway to identify additional therapeutically relevant kinase targets and to develop and test inhibitors of those proteins in a variety of human malignancies. However, it has also become clear that the clinical benefit associated with these agents is typically limited to a subset of treated patients, who in many cases are defined by a specific genomic lesion within their tumor cells—frequently, an activating mutation within the gene encoding the target kinase. This discov...

Magnetic Resonance Imaging Screening of the Contralateral Breast in Women With Newly Diagnosed Breast Cancer: Systematic Review and Meta-Analysis of Incremental Cancer Detection and Impact on Surgical Management [REVIEW ARTICLE]

Journal of Clinical Oncology — Wed, 18 Nov 2009 23:02:37 +0100

Conclusion MRI detects contralateral lesions in a substantial proportion of women, but does not reliably distinguish benign from malignant findings. Relatively high ICDR may be due to selection bias and/or overdetection. Women must be informed of the uncertain benefit and potential harm, including additional investigations and surgery. (Source: Journal of Clinical Oncology)

Randomized Phase II/III Trial Assessing Gemcitabine/ Carboplatin and Methotrexate/Carboplatin/Vinblastine in Patients With Advanced Urothelial Cancer "Unfit" for Cisplatin-Based Chemotherapy: Phase II--Results of EORTC Study 30986 [Genitourinary Cancer]

Journal of Clinical Oncology — Wed, 18 Nov 2009 23:02:37 +0100

Conclusion Both combinations are active in this group of unfit patients. However, patients with PS 2 and GFR less than 60 mL/min do not benefit from combination CHT. Alternative treatment modalities should be sought in this subgroup of poor-risk patients. (Source: Journal of Clinical Oncology)

Prospective Study of Prostate Tumor Angiogenesis and Cancer-Specific Mortality in the Health Professionals Follow-Up Study [Genitourinary Cancer]

Journal of Clinical Oncology — Wed, 18 Nov 2009 23:02:37 +0100

Conclusion Aggressive tumors form vessels that are primitive in morphology and function, with consequences for metastases. Vascular size and irregularity reflect the angiogenic potential of prostate cancer and may serve as biomarkers to predict prostate cancer mortality several years after diagnosis. (Source: Journal of Clinical Oncology)

Genetic Abnormalities of the EGFR Pathway in African American Patients With Non-Small-Cell Lung Cancer [Thoracic Oncology]

Journal of Clinical Oncology — Wed, 18 Nov 2009 23:02:37 +0100

Conclusion African American patients with NSCLC are significantly less likely than white counterparts to harbor activating mutations of EGFR, which suggests that EGFR tyrosine kinase inhibitors (TKIs) are unlikely to yield major remissions in this population. Our findings add to a growing body of evidence that points to genetic heterogeneity of the EGFR pathway in NSCLC among different ethnic groups and that underscores the need for consideration of these differences in the design of future trials of agents that target the EGFR pathway. (Source: Journal of Clinical Oncology)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Targeted High-Resolution Ultrasound Is Not an Effective Substitute for Sentinel Lymph Node Biopsy in Patients With Primary Cutaneous Melanoma [Melanoma]

Journal of Clinical Oncology — Wed, 18 Nov 2009 23:02:37 +0100

Conclusion US is not an appropriate substitute for SLN biopsy, but it is of value in preoperative SLN assessment and postoperative monitoring. (Source: Journal of Clinical Oncology)

Evidence-Based Approach to the Introduction of Positron Emission Tomography in Ontario, Canada [Health Services and Outcomes]

Journal of Clinical Oncology — Wed, 18 Nov 2009 23:02:37 +0100

Conclusion The proliferation of health technologies is a key driver of increasing health care costs. The Ontario approach to the introduction of PET is a model worth consideration by health systems seeking to ensure that they receive value for money based on a strong evidentiary base when introducing new health technologies. (Source: Journal of Clinical Oncology)

Cediranib, an Oral Inhibitor of Vascular Endothelial Growth Factor Receptor Kinases, Is an Active Drug in Recurrent Epithelial Ovarian, Fallopian Tube, and Peritoneal Cancer [Gynecologic Cancer]

Journal of Clinical Oncology — Wed, 18 Nov 2009 23:02:37 +0100

Conclusion Cediranib has activity in recurrent EOC, tubal cancer, and peritoneal cancer with predictable toxicities observed with other TKIs. (Source: Journal of Clinical Oncology)

Reply to G. Ferretti et al [CORRESPONDENCE]

Journal of Clinical Oncology — Wed, 18 Nov 2009 23:02:37 +0100

(Source: Journal of Clinical Oncology)

Darbepoetin Alfa and History of Thromboembolic Events [CORRESPONDENCE]

Journal of Clinical Oncology — Wed, 18 Nov 2009 23:02:37 +0100

(Source: Journal of Clinical Oncology)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Reply to A. Vazquez-Martin et al [CORRESPONDENCE]

Journal of Clinical Oncology — Wed, 18 Nov 2009 23:02:37 +0100

(Source: Journal of Clinical Oncology)

If Mammalian Target of Metformin Indirectly Is Mammalian Target of Rapamycin, Then the Insulin-Like Growth Factor-1 Receptor Axis Will Audit the Efficacy of Metformin in Cancer Clinical Trials [CORRESPONDENCE]

Journal of Clinical Oncology — Wed, 18 Nov 2009 23:02:37 +0100

(Source: Journal of Clinical Oncology)

Reply to F. Puglisi [CORRESPONDENCE]

Journal of Clinical Oncology — Wed, 18 Nov 2009 23:02:37 +0100

(Source: Journal of Clinical Oncology)

What Does Similarity Mean in Clinical Trials? [CORRESPONDENCE]

Journal of Clinical Oncology — Wed, 18 Nov 2009 23:02:37 +0100

(Source: Journal of Clinical Oncology)