MedWorm: Cancer & Oncology

Multiengine Speech Processing Using SNR Estimator in Variable Noisy Environments

Journal of Oncology — Wed, 08 Feb 2012 13:24:10 +0100

We introduce a multiengine speech processing system that can detect the location and the type of audio signal in variable noisy environments. This system detects the location of the audio source using a microphone array; the system examines the audio first, determines if it is speech/nonspeech, then estimates the value of the signal to noise (SNR) using a Discrete-Valued SNR Estimator. Using this SNR value, instead of trying to adapt the speech signal to the speech processing system, we adapt the speech processing system to the surrounding environment of the captured speech signal. In this paper, we introduced the Discrete-Valued SNR Estimator and a multiengine classifier, using Multiengine Selection or Multiengine Weighted Fusion. Also we use the SI as example of the speech processing. T...

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Visual Field Loss Morphology in High- and Normal-Tension Glaucoma

Journal of Oncology — Wed, 08 Feb 2012 13:24:10 +0100

Conclusions. These data suggested that there was no relevant difference in the pointwise analysis between NTG and HTG; however, when visual field areas were compared, no difference in paracentral areas was found between NTG and HTG, but superior nasal step and inferior and superior scotomata showed to be deeper in HTG than in NTG. (Source: Journal of Oncology)

Microarray Analyses of Genes Differentially Expressed by Diet (Black Beans and Soy Flour) during Azoxymethane-Induced Colon Carcinogenesis in Rats

Journal of Oncology — Wed, 08 Feb 2012 13:24:10 +0100

The objective of this study was to identify genes altered by carcinogen treatment in normal-appearing colonic mucosa and those attenuated by bean feeding. Ninety-five male F344 rats were fed control (AIN) diets upon arrival. At 4 and 5 weeks, rats were injected with AOM (15 mg/kg) or saline and one week later administered an AIN, BB-, or SF-based diet. Rats were sacrificed after 31 weeks, and microarrays were conducted on RNA isolated from the distal colonic mucosa. AOM treatment induced a number of genes involved in immunity, including several MHC II-associated antigens and innate defense genes (RatNP-3, Lyz2, Pla2g2a). BB- and SF-fed rats exhibited a higher expression of genes involved in energy metabolism and water and sodium absorption and lower expression of innate (RatNP-3, Pl...

Electrical Properties of Rapidly Annealed Ir and Ir/Au Schottky Contacts on n-Type InGaN

Journal of Oncology — Wed, 08 Feb 2012 13:24:10 +0100

The effect of annealing temperature on electrical characteristics of iridium (Ir) and iridium/gold (Ir/Au) Schottky contacts to n-type InGaN have been investigated by means of current-voltage (I-V) and capacitance-voltage (C-V) techniques. It is observed that the barrier height of Ir/n-InGaN and Au/Ir/n-InGaN Schottky diodes increases after annealing at 300∘C for 1 min in N2 ambient compared to the as-deposited. However, the barrier heights are found to be decreased somewhat after annealing at 500∘C for the both Ir and Ir/Au Schottky contacts. From the above observations, it is clear that the optimum annealing temperature for both Ir and Ir/Au Schottky contacts is 300∘C. Moreover, the barrier height (ϕb), ideality factor (n) and series resistance (RS) are...

Effects of Brugmansia arborea Extract and Its Secondary Metabolites on Morphine Tolerance and Dependence in Mice

Journal of Oncology — Wed, 08 Feb 2012 13:24:10 +0100

The aim of the present study was to investigate, in vivo, the effect of a Brugmansia arborea extract (BRU), chromatographic fractions (FA and FNA), and isolated alkaloids on the expression and the acquisition of morphine tolerance and dependence. Substances were acutely (for expression) or repeatedly (for acquisition) administered in mice treated with morphine twice daily for 5 or 6 days, in order to make them tolerant or dependent. Morphine tolerance was assessed using the tail-flick test at 1st and 5th days. Morphine dependence was evaluated through the manifestation of withdrawal symptoms induced by naloxone injection at 6th day. Results showed that BRU significantly reduced the expression of morphine tolerance, while it was ineffective to modulate its acquisition. Chromatographic fract...

Design and Optimization of a Millimetre Wave Compact Folded Magic-T

Journal of Oncology — Wed, 08 Feb 2012 13:24:10 +0100

A millimetre wave-folded magic-T junction compensated with metal cone is designed using a particle swarm optimization (PSO) algorithm. An off-centred metallic frustum was used to enhance the bandwidth and a metallic post is used to compensate the mismatched E-arm. The geometrical parameters of the frustum and the post are optimized by PSO. The optimized magic-T for W-band application is designed and tested. The design features are simple in structure and easy to fabricate. The 2% bandwidth with centre frequency of 94 GHz and return loss less than −20 dB is achieved. (Source: Journal of Oncology)

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Spectral Distortion in Lossy Compression of Hyperspectral Data

Journal of Oncology — Wed, 08 Feb 2012 13:24:10 +0100

Distortion allocation varying with wavelength in lossy compression of hyperspectral imagery is investigated, with the aim of minimizing the spectral distortion between original and decompressed data. The absolute angular error, or spectral angle mapper (SAM), is used to quantify spectral distortion, while radiometric distortions are measured by maximum absolute deviation (MAD) for near-lossless methods, for example, differential pulse code modulation (DPCM), or mean-squared error (MSE) for lossy methods, for example, spectral decorrelation followed by JPEG 2000. Two strategies of interband distortion allocation are compared: given a target average bit rate, distortion may be set to be constant with wavelength. Otherwise, it may be allocated proportionally to the noise level of each band, a...

Factors That Influence HIV Risk among Hispanic Female Immigrants and Their Implications for HIV Prevention Interventions

Journal of Oncology — Wed, 08 Feb 2012 13:24:10 +0100

Hispanics are the fastest growing minority group in North Carolina with increasing incidence of HIV infection. Gender roles, cultural expectations, and acculturation of women may explain some of Hispanic women’s risks. The perspectives of Hispanic female immigrants and community-based providers were sought to identify services they offer, understand HIV risk factors, and support the adaptation of a best-evidence HIV behavioural intervention for Hispanic women. Two sets of focus groups were conducted to explicate risks and the opportunities to reach women or couples and the feasibility to conduct HIV prevention in an acceptable manner. Salient findings were that Hispanic female immigrants lacked accurate HIV/AIDS and STI knowledge and that traditional gender roles shaped issues surroundin...

Seasonal Changes in Testes Vascularisation in the Domestic Cat (Felis domesticus): Evaluation of Microvasculature, Angiogenic Activity, and Endothelial Cell Expression

Journal of Oncology — Wed, 08 Feb 2012 13:24:10 +0100

The objective of this study was to understand the effect of seasonality on: (i) microvasculature of cat testes; (ii) angiogenic activity in testicular tissue in vitro; and (iii) testicular endothelial cells expression throughout the year. Testicular vascular areas increased in March and April, June and July, being the highest in November and December. Testes tissue differently stimulated in vitro angiogenic activity, according to seasonality, being more evident in February, and November and December. Even though CD143 expression was higher in December, smaller peaks were present in April and July. As changes in angiogenesis may play a role on testes vascular growth and regression during the breeding and non-breeding seasons, data suggest that testicular vascularisation in cats is increased...

Lung Cancer — Wed, 08 Feb 2012 13:23:50 +0100

(Source: Lung Cancer)

Editorial Board

Lung Cancer — Wed, 08 Feb 2012 13:23:50 +0100

(Source: Lung Cancer)

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Repeat flexible sigmoidoscopy increases colorectal cancer detection rate

MedWire News - Oncology — Wed, 08 Feb 2012 13:23:41 +0100

Repeat screening by flexible sigmoidoscopy after 3 to 5 years increases the detection of colorectal cancer or advanced adenoma by a quarter in women and by a third in men, show results of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. (Source: MedWire News - Oncology)

Living with rotationplasty—Quality of life in rotationplasty patients from childhood to adulthood

Journal of Surgical Oncology — Wed, 08 Feb 2012 13:16:21 +0100

ConclusionsThe assessment of QoL by the SF‐36 questionnaire was effective, and a correspondence was found between what emerged from the quantitative study and the contents of the interview. Knowing the strengths and weaknesses that were highlighted is indispensable for parents and operators when choosing among the various surgical options and to facilitate coming to terms with the injury and the “scars”. J. Surg. Oncol. 2012;105:331–336. © 2012 Wiley Periodicals, Inc. (Source: Journal of Surgical Oncology)

Does preoperative therapy optimize outcomes in patients with resectable pancreatic cancer?

Journal of Surgical Oncology — Wed, 08 Feb 2012 13:14:09 +0100

The objective of this study was to compare survival between all patients with radiographically resectable adenocarcinoma of the proximal pancreas who underwent preoperative chemoradiation therapy (PRE‐OP CRT) or surgical exploration first (SURGERY) with “intention to resect.” Pancreatic cancer patients who undergo resection after PREOP CRT live longer than patients who undergo resection without PREOP CRT, a difference that may be attributable to patient selection. We retrospectively identified 236 patients with pancreatic head adenocarcinoma seen between 1999 and 2007 with sufficient data to be confirmed medically and radiographically resectable. The outcomes of 144 patients who underwent PREOP CRT were compared to those of 92 patients who proceeded straight to SURGERY. The groups we...

FDA Grants Imatinib (Gleevec) Full Approval for Adjuvant Treatment of GIST

Cancer Network — Wed, 08 Feb 2012 13:00:02 +0100

The FDA has granted imatinib full approval as an adjuvant treatment following surgical removal of CD117-positive gastrointestinal stromal tumors in adult patients. This comes after results from a phase III trial showed that patients taking imatinib for 36 months had a 5-year overall survival of 92%, compared to 82% for those patients who took the drug for the standard 12 months of treatment. (Source: Cancer Network)

The results of treatment of children with metastatic Wilms tumours (WT) in an African setting: Do liver metastases have a negative impact on survival?

Pediatric Blood and Cancer — Wed, 08 Feb 2012 12:57:11 +0100

ConclusionsIn Africa liver metastases do not appear to worsen the prognosis of children with Stage IV WT. Despite the poor socio‐economic circumstances survival is comparable to other countries. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer)

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Antiparkinsonian Mechanism of Electroconvulsive Therapy in MPTP-Lesioned Non-Human Primates

Karger Publishers — Wed, 08 Feb 2012 12:48:07 +0100

Neurodegenerative Dis (DOI:10.1159/000334497) (Source: Karger Publishers)

Evaluation of Neurodegeneration in a Mouse Model of Infantile Batten Disease by Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy

Karger Publishers — Wed, 08 Feb 2012 12:48:07 +0100

Neurodegenerative Dis (DOI:10.1159/000334838) (Source: Karger Publishers)

APOE-Mimetic Peptides Reduce Behavioral Deficits, Plaques and Tangles in Alzheimer's Disease Transgenics

Karger Publishers — Wed, 08 Feb 2012 12:48:07 +0100

Neurodegenerative Dis (DOI:10.1159/000334914) (Source: Karger Publishers)

The Gastrin-Releasing Peptide Receptor as a Marker of Dysplastic Alterations in Cervical Epithelial Cells

Karger Publishers — Wed, 08 Feb 2012 12:48:07 +0100

Oncology 2012;82:90-97 (DOI:10.1159/000335955) (Source: Karger Publishers)

Expression of Epidermal Growth Factors, erbBs, in the Nasal Mucosa of Patients with Chronic Hypertrophic Rhinitis

Karger Publishers — Wed, 08 Feb 2012 12:48:07 +0100

ORL 2012;74:57-63 (DOI:10.1159/000335583) (Source: Karger Publishers)

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Planned Neck Dissection before Combined Chemoradiation in Organ Preservation Protocol for N2-N3 of Supraglottic or Hypopharyngeal Carcinoma

Karger Publishers — Wed, 08 Feb 2012 12:48:07 +0100

ORL 2012;74:64-69 (DOI:10.1159/000333111) (Source: Karger Publishers)

Leptin in Anorexia and Cachexia Syndrome

Clinical and Developmental Immunology — Wed, 08 Feb 2012 11:20:54 +0100

Leptin is a product of the obese (OB) gene secreted by adipocytes in proportion to fat mass. It decreases food intake and increases energy expenditure by affecting the balance between orexigenic and anorexigenic hypothalamic pathways. Low leptin levels are responsible for the compensatory increase in appetite and body weight and decreased energy expenditure (EE) following caloric deprivation. The anorexia-cachexia syndrome is a complication of many chronic conditions including cancer, chronic obstructive pulmonary disease, congestive heart failure, chronic kidney disease, and aging, where the decrease in body weight and food intake is not followed by a compensatory increase in appetite or decreased EE. Crosstalk between leptin and inflammatory signaling known to be activated in these condi...

MOfinder: A Novel Algorithm for Detecting Overlapping Modules from Protein-Protein Interaction Network

Clinical and Developmental Immunology — Wed, 08 Feb 2012 11:20:54 +0100

In this study, a new method, MOfinder, was developed to detect overlapping modules in a protein-protein interaction (PPI) network. We demonstrate that our method is more accurate than other 5 methods. Then, we applied MOfinder to yeast and human PPI network and explored the overlapping information. Using the overlapping modules of human PPI network, we constructed the module-module communication network. Functional annotation showed that the immune-related and cancer-related proteins were always together and present in the same modules, which offer some clues for immune therapy for cancer. Our study around overlapping modules suggests a new perspective on the analysis of PPI network and improves our understanding of disease. (Source: Clinical and Developmental Immunology)

Targeting HLA class I expression to increase tumor immunogenicity

Tissue Antigens — Wed, 08 Feb 2012 11:12:45 +0100

The dynamic interaction between the host immune system and growing cancer has been of central interest to the field of tumor immunology over the past years. Recognition of tumor‐associated antigens (TAA) by self‐HLA (human leukocyte antigen) class I‐restricted CD8+ T cells is a main feature in the detection and destruction of malignant cells. The discovery and molecular characterization of TAA has changed the field of cancer treatment and introduced a new era of cancer immunotherapy aimed at increasing tumor immunogenicity and T‐cell‐mediated anti‐tumor immunity. Unfortunately, while these new protocols of cancer immunotherapy are mediating induction of tumor‐specific T lymphocytes in patients with certain malignancies, they have not yet delivered substantial clinical benefit...

The impact of lung cancer on patients and carers.

Chronic Respiratory Disease — Wed, 08 Feb 2012 09:06:02 +0100

This article aims to provide a brief review of the literature with regard to the impact of lung cancer on patients and their informal carers. Compared to other types of cancer, the distress associated with lung cancer has been found to be the most intense. Rather than focusing on symptoms in isolation recent emphasis regarding the symptom experience has been on symptoms clusters, as understanding these clusters may improve the management of ongoing and unrelieved symptoms. However, the disparities in methodology are significant barriers to producing comparable results, although recent efforts have been made to address these. Whilst research into symptoms has enormous potential for the management of symptom clusters, it needs to move away from the essentially reductionist stance which curre...

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For Personalizing Cancer Therapy, Metabolic Profiles Are Essential

Health News from Medical News Today — Wed, 08 Feb 2012 09:00:00 +0100

One way to tackle a tumor is to take aim at the metabolic reactions that fuel their growth. But a report in the February Cell Metabolism, a Cell Press Publication, shows that one metabolism-targeted cancer therapy will not fit all. That means that metabolic profiling will be essential for defining each cancer and choosing the best treatment accordingly, the researchers say. The evidence comes from studies in mice showing that tumors' metabolic profiles vary based on the genes underlying a particular cancer and on the tissue of origin... (Source: Health News from Medical News Today)

Early Signs Of Disease Detected By Metabolic 'Breathalyzer'

Health News from Medical News Today — Wed, 08 Feb 2012 09:00:00 +0100

The future of disease diagnosis may lie in a "breathalyzer"-like technology currently under development at the University of Wisconsin-Madison. New research published online in February in the peer-reviewed journal Metabolism demonstrates a simple but sensitive method that can distinguish normal and disease-state glucose metabolism by a quick assay of blood or exhaled air. Many diseases, including diabetes, cancer, and infections, alter the body's metabolism in distinctive ways... (Source: Health News from Medical News Today)

Key Finding In Stem Cell Self-Renewal

Health News from Medical News Today — Wed, 08 Feb 2012 09:00:00 +0100

A University of Minnesota-led research team has proposed a mechanism for the control of whether embryonic stem cells continue to proliferate and stay stem cells, or differentiate into adult cells like brain, liver or skin. The work has implications in two areas. In cancer treatment, it is desirable to inhibit cell proliferation. But to grow adult stem cells for transplantation to victims of injury or disease, it would be desirable to sustain proliferation until a sufficient number of cells have been produced to make a usable organ or tissue... (Source: Health News from Medical News Today)

More Accurate Diagnosis, Prognosis In Challenging Breast Cancer Cases Provided By PET Techniques

Health News from Medical News Today — Wed, 08 Feb 2012 08:00:00 +0100

In two new studies featured in the February issue of The Journal of Nuclear Medicine, researchers are revealing how molecular imaging can be used to solve mysteries about difficult cases of breast cancer. One article focuses on an imaging agent that targets estrogen receptors in estrogen receptor-positive breast cancer patients with formerly inconclusive assessments, and the second highlights a different imaging agent's ability to help predict the prognosis for patients undergoing chemotherapy for a very aggressive type of breast cancer... (Source: Health News from Medical News Today)

Patient Sensitivity To Important Drug Target In Deadly Brain Cancer Predicted

Health News from Medical News Today — Wed, 08 Feb 2012 08:00:00 +0100

A recent discovery by Van Andel Research Institute (VARI) scientists enables the prediction of patient sensitivity to proposed drug therapies for glioblastoma - the most common and most aggressive malignant brain tumor in humans. The study, published in the Proceedings of the National Academy of Science, investigated glioblastoma models characterized by cell signaling activation and gene amplification for their susceptibility to inhibitors of both the human MET oncogene and the epidermal growth factor receptor (EFGR). An oncogene is a gene with the potential to cause cancer... (Source: Health News from Medical News Today)

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Zinc Control Mechanisms Could Be Key To Aggressive Breast Cancer Treatments

Health News from Medical News Today — Wed, 08 Feb 2012 08:00:00 +0100

The body's control mechanisms for delivering zinc to cells could be key to improving treatment for some types of aggressive breast cancer. New research by Cardiff University and King's College London has identified the switch which releases zinc into cells, with important implications for a number of diseases. Zinc has long been known to play a vital part in human health. Too much zinc, or too little, can cause cell death. A growing body of evidence links zinc to disease states including neurodegeneration, inflammation, diabetes and cancer... (Source: Health News from Medical News Today)

Women Born To Older Mothers Have A Higher Risk Of Developing Breast Cancer

Health News from Medical News Today — Wed, 08 Feb 2012 08:00:00 +0100

A new study analyses the influence that certain birth and infancy characteristics have on mammographic density - an important indicator of breast cancer risk. The results reveal that women born to mothers aged over 39 years and women who were taller and thinner than the average girl prior to puberty have a higher breast density. This brings with it an increased risk of developing breast cancer... (Source: Health News from Medical News Today)

Men with low-risk prostate cancer may benefit from dutasteride, active surveillance

HemOncToday.com — Wed, 08 Feb 2012 07:38:00 +0100

Fleshner NE. Lancet. 2012;doi:10.1016/S0140-6736(11)61619-X. (Source: HemOncToday.com)

After Outcry, Karen Handel Resigns From Komen

NYT — Wed, 08 Feb 2012 06:04:06 +0100

Karen Handel’s resignation came just days after the cancer foundation reversed its decision to cut funds to Planned Parenthood. (Source: NYT)

Top9ColCanRiskFactors

About.com Colon Cancer — Wed, 08 Feb 2012 05:00:00 +0100

Many of the top nine colon cancer risk factors are things you can change. Take the steps needed for better health and eliminate many of your colon cancer risk factors, too. (Source: About.com Colon Cancer)

basics of lymphedema

About.com Breast Cancer — Wed, 08 Feb 2012 05:00:00 +0100

Lymphedema is swelling that occurs due to the accumulation of lymphatic fluid (also called lymph) in an arm, or sometimes a leg. Many people who've undergone treatment for breast cancer worry about developing lymphedema. What are the symptoms of lymphedema to be on the lookout for? Arm yourself with knowledge about who gets lymphedema, how it is diagnosed, and how it is treated. (Source: About.com Breast Cancer)

Overexpression of DNA damage-induced 45 alpha gene contributes to esophageal squamous cell cancer by promoter hypomethylation

Journal of Experimental and Clinical Cancer Research — Wed, 08 Feb 2012 05:00:00 +0100

Conclusion: Overexpression of GADD45alpha gene is due to DNA hypomethylation in ESCC. GADD45alpha may be a protective factor in DDP chemotherapy for esophageal squamous cell carcinoma. (Source: Journal of Experimental and Clinical Cancer Research)

Improving adherence to surveillance and screening recommendations for people with colorectal cancer and their first degree relatives: A randomized controlled trial

BMC Cancer — Wed, 08 Feb 2012 05:00:00 +0100

DiscussionResults of this study will contribute to the evidence base about effective strategies to a) improve adherence to surveillance recommendation for people with CRC; and b) improve adherence to screening recommendation for FDRs of people with CRC. The use of a population-based cancer registry to access the target population may have significant advantages in increasing the reach of the intervention. (Source: BMC Cancer)

The role and function of cadherins in the mammary gland

Breast Cancer Research — Wed, 08 Feb 2012 05:00:00 +0100

Cadherins are transmembrane receptors that function through calcium-dependent homophilic and heterophilic interactions that provide cell-cell contact and communication in many different organ systems. In the mammary gland only a few of the cadherins that make up this large superfamily of proteins have been characterized. Frequently in metastatic breast cancer, the genes for cadherins are epigenetically silenced, mutated, or regulated differently. During epithelial mesenchymal transition, cadherins that are expressed normally in the epithelial cells are down regulated, while cadherins expressed in the mesenchyme are up regulated. This process is known as cadherin switching, and its regulation can sometime facilitates the increase motility, invasiveness and proliferation that occurs in meta...

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Key signaling nodes in mammary gland development and cancer: Smad signal integration in epithelial cell plasticity

Breast Cancer Research — Wed, 08 Feb 2012 05:00:00 +0100

Smad proteins are the key intermediates of TGF-beta-signaling during development and in tissue homeostasis. Pertubations in TGF-beta/Smad signaling have been implicated in cancer, and other diseases. In the cell nucleus Smad complexes trigger cell type- and context-specific transcriptional programs, thereby transmitting and integrating signals from a variety of ligands of the TGF-beta-superfamily and other stimuli in the cell micro-environment. The actual transcriptional and biological outcome of Smad activation critically depends on the genomic integrity and the modification state of genome and chromatin of the cell. The cytoplasmic and nuclear Smads can also modulate the activity of other signal transducers and enzymes such as microRNA processing factors. In the case of breast cancer the...

Research partnership to improve treatments for cancer patients

EurekAlert! - Medicine and Health — Wed, 08 Feb 2012 05:00:00 +0100

(Walter and Eliza Hall Institute) The Australian Cancer Research Foundation has committed $2 million towards the fit-out of two new cancer research laboratories at the Walter and Eliza Hall Institute. (Source: EurekAlert! - Medicine and Health)

Prognostic value of bcl-2 and bax tumor cell expression in patients with non muscle-invasive bladder cancer receiving bacillus calmette-guerin immunotherapy.

Ultrastructural Pathology — Wed, 08 Feb 2012 03:06:09 +0100

In conclusion, the expression of Bcl-2 and Bax in NMIBC could have a prognostic value in assessing the risk of recurrence after BCG immunotherapy. These findings require further investigations on larger cohort in order to ascertain new molecular markers of the response to BCG immunotherapy. PMID: 22292735 [PubMed - in process] (Source: Ultrastructural Pathology)

Pilot study on evaluation of any correlation between MR perfusion (K(trans)) and diffusion (apparent diffusion coefficient) parameters in brain tumors at 3 Tesla.

Cancer Imaging — Wed, 08 Feb 2012 00:30:02 +0100

Conclusion: We found that irrespective of brain tumor type, there is an inverse correlation between ADC and K(trans). Our findings highlight an intricate relationship between vascular permeability and the tumor microenvironment, probably modulating and/or interacting with changes such as increased cellularity, ischemic insult and varying extracellular matrix composition. PMID: 22275724 [PubMed - in process] (Source: Cancer Imaging)

Diffuse pulmonary uptake on FDG-PET with normal CT diagnosed as intravascular large B-cell lymphoma: a case report and a discussion of the causes of diffuse FDG uptake in the lungs.

Cancer Imaging — Wed, 08 Feb 2012 00:30:02 +0100

Authors: Wagner T, Brechemier D, Dugert E, Le Guellec S, Julian A, Hitzel A, Beyne-Rauzy O Abstract A 71-year-old woman was admitted to our hospital with asthenia, weight loss, fever, cognitive impairment and shortness of breath. Physical examination showed hemiparesis and cerebellar ataxia. There was no superficial lymphadenopathy. Blood tests showed raised levels of C-reactive protein and lactate dehydrogenase. Bone marrow aspiration and biopsy were negative. [(18)F]fluorodeoxyglucose (FDG)-positron emission tomography (PET)/computed tomography (CT) showed intense uptake within a right apical nodule and intense and diffuse uptake of FDG in the lungs without corresponding structural CT abnormality. Lung biopsy showed intravascular large B-cell lymphoma (IVLBCL). FDG-PET findings i...

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The emergence of diagnostic imaging technologies in breast cancer: discovery, regulatory approval, reimbursement, and adoption in clinical guidelines.

Cancer Imaging — Wed, 08 Feb 2012 00:30:02 +0100

Authors: Gold LS, Klein G, Carr L, Kessler L, Sullivan SD Abstract In this article, we trace the chronology of developments in breast imaging technologies that are used for diagnosis and staging of breast cancer, including mammography, ultrasonography, magnetic resonance imaging, computed tomography, and positron emission tomography. We explore factors that affected clinical acceptance and utilization of these technologies from discovery to clinical use, including milestones in peer-reviewed publication, US Food and Drug Administration approval, reimbursement by payers, and adoption into clinical guidelines. The factors driving utilization of new imaging technologies are mainly driven by regulatory approval and reimbursement by payers rather than evidence that they provide benefits...

Atypical lipomatous tumor with unusual extensive metaplastic ossification.

Cancer Imaging — Wed, 08 Feb 2012 00:30:02 +0100

We report a case of ALT/WDLPS with unusual extensive metaplastic bone formation without an element of dedifferentiated liposarcoma. PMID: 22294061 [PubMed - in process] (Source: Cancer Imaging)

CT-based quantitative SPECT for the radionuclide (201)Tl: experimental validation and a standardized uptake value for brain tumour patients.

Cancer Imaging — Wed, 08 Feb 2012 00:30:02 +0100

Authors: Willowson K, Bailey D, Schembri G, Baldock C Abstract We have previously reported on a method for reconstructing quantitative data from (99m)Tc single photon emission computed tomography (SPECT) images based on corrections derived from X-ray computed tomography, producing accurate results in both experimental and clinical studies. This has been extended for use with the radionuclide (201)Tl. Accuracy was evaluated with experimental phantom studies, including corrections for partial volume effects where necessary. The quantitative technique was used to derive standardized uptake values (SUVs) for (201)Tl evaluation of brain tumours. A preliminary study was performed on 26 patients using (201)Tl SPECT scans to assess residual tumour after surgery and then to monitor response...

Risk of Death From Certain Breast Cancers May Rise With Age

Cancercompass News: Breast Cancer — Wed, 08 Feb 2012 00:00:00 +0100

Research focused on estrogen-sensitive tumors; undertreatment might play a role, expert says (Source: Cancercompass News: Breast Cancer)

Komen official resigns over Planned Parenthood dispute

USATODAY.com Health — Tue, 07 Feb 2012 23:06:15 +0100

An executive with a major U.S. breast-cancer charity has resigned after a dispute over funding for the best-known family planning organizati ... (Source: USATODAY.com Health)

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Perception versus Reality: The Measuring of Pleural Fluid pH in the United States

Karger Publishers — Tue, 07 Feb 2012 23:00:00 +0100

Respiration (DOI:10.1159/000335134) (Source: Karger Publishers)

Topical Imiquimod 5% Cream for Pediatric Plaque Morphea: A Prospective, Multiple-Baseline, Open-Label Pilot Study

Karger Publishers — Tue, 07 Feb 2012 23:00:00 +0100

Dermatology (DOI:10.1159/000335560) (Source: Karger Publishers)

Systolic Heart Function, Kidney Filtration and the Number of Coronary Atherosclerotic Plaques in Lean and Overweight Patients

Karger Publishers — Tue, 07 Feb 2012 23:00:00 +0100

Cardiorenal Med 2012;2:110-116 (DOI:10.1159/000335561) (Source: Karger Publishers)

High Incidence of Internal Malignancy in Papuloerythroderma of Ofuji: A Case Series from Japan

Karger Publishers — Tue, 07 Feb 2012 23:00:00 +0100

Dermatology (DOI:10.1159/000335563) (Source: Karger Publishers)

Diagnosis and Treatment of Hyper-Delayed Graft Function after Renal Transplantation

Karger Publishers — Tue, 07 Feb 2012 23:00:00 +0100

Urol Int (DOI:10.1159/000335818) (Source: Karger Publishers)

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Feasibility and Safety of Early Removal of Incisional Dressings following Thoracic Surgery

Karger Publishers — Tue, 07 Feb 2012 23:00:00 +0100

Med Princ Pract (DOI:10.1159/000335987) (Source: Karger Publishers)

Evolution of Sensory Development – Lessons from the Lateral Line

Karger Publishers — Tue, 07 Feb 2012 23:00:00 +0100

Brain Behav Evol 2012;79:73–74 (DOI:10.1159/000335696) (Source: Karger Publishers)

Alcohol Consumption and Its Relation to Visceral and Subcutaneous Adipose Tissues in Healthy Male Koreans

Karger Publishers — Tue, 07 Feb 2012 23:00:00 +0100

Ann Nutr Metab 2012;60:64-73 (DOI:10.1159/000334710) (Source: Karger Publishers)

Cholesterol Is Associated with the Presence of a Lipid Core in Carotid Plaque of Asymptomatic, Young-to-Middle-Aged African Americans with and without HIV Infection and Cocaine Use Residing in Inner-City Baltimore, Md., USA

Karger Publishers — Tue, 07 Feb 2012 23:00:00 +0100

Cerebrovasc Dis 2012;33:295-301 (DOI:10.1159/000334661) (Source: Karger Publishers)

Genetic Polymorphisms of FcγRIIa and FcγRIIIa Are Not Predictive of Clinical Outcomes after Cetuximab plus Irinotecan Chemotherapy in Patients with Metastatic Colorectal Cancer

Karger Publishers — Tue, 07 Feb 2012 23:00:00 +0100

Oncology 2012;82:83-89 (DOI:10.1159/000335959) (Source: Karger Publishers)

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Cochlear Implantation in Posttraumatic Bilateral Temporal Bone Fracture

Karger Publishers — Tue, 07 Feb 2012 23:00:00 +0100

ORL 2012;74:52-56 (DOI:10.1159/000335931) (Source: Karger Publishers)

Differences in Survival between Patients with Dementia with Lewy Bodies and Patients with Alzheimer's Disease - Measured from a Fixed Cognitive Level

Karger Publishers — Tue, 07 Feb 2012 23:00:00 +0100

Dement Geriatr Cogn Disord 2011;32:408-416 (DOI:10.1159/000335364) (Source: Karger Publishers)

Trends in the Incidence of Biopsy-Proven Glomerular Diseases in the Adult Population in Central Poland in the Years 1990-2010

Karger Publishers — Tue, 07 Feb 2012 23:00:00 +0100

Kidney Blood Press Res 2012;35:254-258 (DOI:10.1159/000334418) (Source: Karger Publishers)

Older Age Worsens Breast Cancer Prognosis (CME/CE)

MedPage Today State Required CME — Tue, 07 Feb 2012 22:13:11 +0100

(MedPage Today) -- Older age at diagnosis of postmenopausal, hormone receptor-positive breast cancer may independently worsen outcomes, researchers found. (Source: MedPage Today State Required CME)

Breast cancer kills older women more often

Reuters: Health — Tue, 07 Feb 2012 21:39:25 +0100

NEW YORK (Reuters Health) - Breast cancer is often considered more deadly among younger women, but a new study shows older women are actually more likely to die of the disease. (Source: Reuters: Health)

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Komen VP quits after Planned Parenthood funds restored

bizjournals.com Health Care:Physician Practices headlines — Tue, 07 Feb 2012 21:26:50 +0100

Karen Handel, vice president for public policy of the Dallas-based Susan G. Komen for the Cure breast-cancer charity, has resigned in protest of the group's restoration of funding to Planned Parenthood, according to a Fox News report. In a letter, Handel said that she supported the charity's move last week to cut off funding to Planned Parenthood. The decision was later reversed after a firestorm of protest erupted across the nation. "I am deeply disappointed by the gross mischaracterizations of the strategy, its rationale, and my involvement in it,” Handel said in her letter... (Source: bizjournals.com Health Care:Physician Practices headlines)

Ovarian Cancer Screening Common Despite Lack of Proof (CME/CE)

MedPage Today Public Health — Tue, 07 Feb 2012 18:44:38 +0100

(MedPage Today) -- More than 90% of primary care physicians reported ordering ovarian cancer screening tests not recommended for women with a low or average risk for the disease, a national survey showed. (Source: MedPage Today Public Health)

Komen Official Quits After Controversy

MedPage Today Public Health — Tue, 07 Feb 2012 18:23:16 +0100

(MedPage Today) -- A vice-president at the Susan G. Komen for the Cure Foundation has resigned in the wake of the controversy surrounding the organization's decision -- since reversed -- to stop funding Planned Parenthood's breast cancer programs. (Source: MedPage Today Public Health)

Roche breast cancer drug gets FDA priority review

Reuters: Health — Tue, 07 Feb 2012 18:15:26 +0100

(Reuters) - Health regulators granted a priority review for an experimental Roche breast cancer drug that in clinical trials added six months to the time before the disease worsened. (Source: Reuters: Health)

Breast Cancer Drug May Weaken Bones, Study Finds

The Doctors Lounge - Oncology — Tue, 07 Feb 2012 18:00:00 +0100

Researchers say postmenopausal women taking Aromasin need to be monitored (Source: The Doctors Lounge - Oncology)

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Navigating Treatment Decisions

Kidney Cancer Association — Tue, 07 Feb 2012 17:54:52 +0100

This article focuses on treatment for clear cell disease, but some of these treatments are also appropriate for patients with non-clear cell disease. Some patients may have only a single metastatic tumor that can be removed by surgery. But most patients with metastatic disease have tumors in many parts of the body. In order to treat all of these tumors, patients are given systemic therapies, which are drugs that travel through the bloodstream and can directly reach cells throughout the body. Immunotherapy is a type of treatment that gives a boost to the immune system. The goal of immunotherapy is to help the patient’s immune system attack the cancer cells. Immunotherapy treatments have been available for decades and have generated renewed interest for treating metastatic RCC ...

Well Blog: A Better Way to Spend Breast Cancer Funds?

NYT — Tue, 07 Feb 2012 17:43:25 +0100

We must move breast cancer advocacy to the next level, beyond screening for cancers that are already there, even beyond the cure, to finding the cause, writes Dr. Susan Love. (Source: NYT)

Komen VP steps down after Planned Parenthood flap

Reuters: Health — Tue, 07 Feb 2012 16:40:26 +0100

WASHINGTON (Reuters) - A senior executive of the breast cancer charity Susan G. Komen for the Cure has resigned after a public outcry over the group's decision to cut funding to women's health organization Planned Parenthood. (Source: Reuters: Health)

Komen official quits breast cancer charity over dispute

USATODAY.com Health — Tue, 07 Feb 2012 16:33:33 +0100

An executive with a major U.S. breast-cancer charity has resigned after a dispute over funding for the best-known family planning organizati ... (Source: USATODAY.com Health)

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Komen official quits over Planned Parenthood

Health News: CBSNews.com — Tue, 07 Feb 2012 15:48:01 +0100

High-ranking official in breast-cancer charity resigns, saying she supported decision to pull Planned Parenthood funding (Source: Health News: CBSNews.com)

Official quits breast cancer charity over funding dispute

CTV Health — Tue, 07 Feb 2012 15:44:18 +0100

An executive with a major U.S. breast-cancer charity has resigned after a dispute over funding for the country's best-known family planning organization. The resignation came in a letter obtained by The Associated Press. (Source: CTV Health)

Official quits breast cancer charity over dispute

USATODAY.com Health — Tue, 07 Feb 2012 15:42:17 +0100

An executive with a major U.S. breast-cancer charity has resigned after a dispute over funding for the best-known family planning organizati ... (Source: USATODAY.com Health)

What is Palliative Care?

Kidney Cancer Association — Tue, 07 Feb 2012 15:30:18 +0100

Dr. Robert Miller discusses the goals of palliative care and how it helps improve patients’ quality of life 02/08/2012 (Source: Kidney Cancer Association)

For physicians: VEGF tyrosine kinase inhibitor treatment risks

Kidney Cancer Association — Tue, 07 Feb 2012 15:22:50 +0100

A recent study led by scientists at Dana-Farber Cancer Institute found an slightly increased risk of fatal side effects in certain patients treated with VEGF-tyrosine kinase inhibitors. Dr. Toni Choueiri, who led the study, explains what physicians need to know about their patients' medical histories, and how they can help educate patients about the benefits and potential risks of these therapies. 02/08/2012 (Source: Kidney Cancer Association)

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FDA grants priority review for HER-2—positive breast cancer treatment

HemOncToday.com — Tue, 07 Feb 2012 15:19:00 +0100

(Source: HemOncToday.com)

Live Kidney Cancer Chat on Tuesdays

Kidney Cancer Association — Tue, 07 Feb 2012 15:10:03 +0100

Join us for a live Facebook chat every Tuesday at 8 a.m. and 8 p.m. Central. The Kidney Cancer Association has more than 45,000 friends on Facebook and anyone interested in the eradication of death and suffering from this disease is welcome to join.02/07/2012 (Source: Kidney Cancer Association)

Primary Cutaneous Melanoma Arising in a Long-Standing Irradiated Keloid

Journal of Nanomaterials — Tue, 07 Feb 2012 14:50:03 +0100

We describe a case in which a primary desmoplastic melanoma arose in a long-standing, previously irradiated keloid. (Source: Journal of Nanomaterials)

FDA questions Amgen drug for prostate cancer

USATODAY.com Health — Tue, 07 Feb 2012 14:15:14 +0100

The FDA will ask a panel of outside experts whether the benefits of Amgen's Xgeva outweigh its risks, which included bone disease. (Source: USATODAY.com Health)

Expanded Palliative Care for All NSCLC PatientsExpanded Palliative Care for All NSCLC Patients

Medscape Today Headlines — Tue, 07 Feb 2012 13:45:52 +0100

An ASCO provisional clinical opinion recommends that all patients with metastatic nonsmall-cell lung cancer (NSCLC) be offered palliative care concurrent with standard therapy, starting at diagnosis. Medscape Medical News (Source: Medscape Today Headlines)

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An orthotopic model of platinum-sensitive high grade serous fallopian tube carcinoma.

International Journal of Clinical and Experimental Pathology — Tue, 07 Feb 2012 13:36:02 +0100

Authors: Khabele D, Fadare O, Liu AY, Wilson AJ, Wass E, Osteen K, Crispens MA Abstract Fallopian tube carcinoma (FTCA) is a very rare cancer type, but may be a useful platform for investigating high grade serous tumors of the pelvis that originate from a serous tubal intraepithelial carcinoma (STIC) precursor. Metastatic tumors from a patient diagnosed with Stage IIIC high grade serous FTCA (P0) were transplanted via intraperitoneal (IP) injection into a small cohort of mice (passage, P1). Patient information was obtained from the medical record. Tumors were grown, harvested and re-implanted or archived through P3. The P3 cohort was treated with saline (n=8) or cisplatin, 5 mg/kg (n=8), weekly for 4 weeks. After sacrifice, tumors from each passage and treatment group were passaged...

Pathologic observations of the duodenum in 615 consecutive duodenal specimens: I. benign lesions.

International Journal of Clinical and Experimental Pathology — Tue, 07 Feb 2012 13:36:02 +0100

Authors: Terada T Abstract The author investigated histopathology of 615 consecutive duodenal specimens in our pathology laboratory. Computer search of the duodenal lesions was performed. Review of histological slides was done, when appropriate. The duodenal specimens were composed of 567 benign lesions and 48 malignant lesions. The 567 benign lesions were composed of chronic non-specific duodenitis in 334 cases (60.0%), duodenal ulcer in 101 cases (17,8%), heterotopic gastric mucosa in 81 cases (14.3%), hyperplastic polyp in 16 cases (2.8%), Brunner's gland hyperplasia in 14 cases (2.5%), Brunner's gland adenoma in 8 cases (1.4%), lymphoid polyp in 5 cases (0.8%), tubular adenoma in 4 cases (0.7%), lymphangioma in 2 cases (0.4%), endocrine nests in 1 case (0.2%), and amyloidosis i...

Pathologic observations of the duodenum in 615 consecutive duodenal specimens in a single Japanese hospital: II. malignant lesions.

International Journal of Clinical and Experimental Pathology — Tue, 07 Feb 2012 13:36:02 +0100

Authors: Terada T Abstract The author investigated histopathology of 615 consecutive duodenal specimens in our pathology laboratory in Japan. A computer review of the duodenal specimens was done. In cases of malignancy, histological slides were reviewed. The duodenal specimens were composed of 567 benign lesions (92%) and 48 malignant lesions (8%). The 48 malignant lesions were composed of 20 cases (42%) of primary adenocarcinoma, 10 cases (21%) of primary adenocarcinoma of ampulla Vater, 4 cases (8%) of primary squamous cell carcinoma, 1 (2%) cases of primary spindle cell carcinoma, 4 (8%) cases of carcinoid tumors, 1 (2%) case of malignant lymphoma, and 8 cases (17%) of secondary carcinoma from the pancreatic carcinoma or bile duct carcinoma. The primary adenocarcinoma (n=20) was...

Clinicopathologic study of endometrial dedifferentiated endometrioid adenocarcinoma: a case report.

International Journal of Clinical and Experimental Pathology — Tue, 07 Feb 2012 13:36:02 +0100

We report herein a first case of endometrial dedifferentiated endometrioid carcinoma in a 51-year old woman in Chinese population. We performed immunoperoxidase studies for 12 markers. Among them, cytokeratins, keratin 7, keratin 18, EMA, estrogen receptor (ER), progesterone receptor (PR), and vimentin show significantly differential expression between differentiated and undifferentiated area. PMID: 22295150 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)

Spindle cell carcinoma progressed from transitional cell carcinoma of the urinary bladder.

International Journal of Clinical and Experimental Pathology — Tue, 07 Feb 2012 13:36:02 +0100

Authors: Terada T Abstract The author reports a very rare case of spindle cell carcinoma (SpCC) of the urinary bladder progressed from ordinary papillary transitional cell carcinoma (TCC). A 63-year-old man complained of hematuria. A transurethral endoscopic examination revealed a papillary tumor, and transuthetral resection of bladder tumor (TUR-BT) was performed and was diagnosed as ordinary papillary urothelial TCC. Since then, he was treated with TUR-BT eight times. Chemotherapy, radiation, radical cystectomy and lymph nodes dissection were performed 16 years after the first TUR-BT. However, he developed rectal mucosal metastasis. He is now alive 17 years after the first presentation. All the TUR-BT specimens were ordinary papillary TCCs without invasion (pTa). Immunohistochemi...

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Malignant intraductal oncocytic papillary neoplasm of the common bile duct.

International Journal of Clinical and Experimental Pathology — Tue, 07 Feb 2012 13:36:02 +0100

Authors: Terada T Abstract Recently, several cases of intraductal oncocytic papillary neoplasm (IOPN) of the liver and hepatic bile ducts have been reported. The author herein reports the first case of IOPN of the common bile duct (CBD). A 78-year-old man was admitted to our hospital because of jaundice. Imaging modalities including US, CT, MRI revealed an intraductal tumor of the middle CBD and biliary dilation distal to the tumor. A partial resection of the CBD was performed. Grossly, a papillary tumor measuring 20 × 15 mm was found within the CBD. Mucus is absent. Histologically, the papillary tumor was composed of atypical oncocytes. The atypia was enough to be diagnosed as adenocarcinoma. No invasive features were noted. Immunohistochemically, the tumor cells were positive fo...

Acquired hemophilia associated with bullous pemphigoid: a case report.

International Journal of Clinical and Experimental Pathology — Tue, 07 Feb 2012 13:36:02 +0100

We described the case of a 60-year-old female patient who developed bullous pemphigoid for 3 month and presented with bleeding tendency and hematoma in the tongue. Therapy with methylprednisolone, cyclophosphamide, intravenous immunoglobulin and factor VIII reposition was instituted, resulting in a remission of the bleeding and negativity for antibodies against factor VIII titers. We concluded that, despite its rarity, the presence of acquired factor VIII inhibitors should be investigated when patients with autoimmune diseases develop bleeding manifestations. PMID: 22295154 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)

Lymphoepithelioma-like carcinoma of the colon.

International Journal of Clinical and Experimental Pathology — Tue, 07 Feb 2012 13:36:02 +0100

Authors: Delaney D, Chetty R Abstract An 85-year old female had a polypoid tumour in the sigmoid colon that histologically conformed to a lymphoepithelioma-like (LEL) carcinoma. The tumour was arranged in cords, chains, clusters and microalveoli of pleomorphic, irregular cells set within a dense intratumoral lymphocytic stroma. The tumour was EBV-negative and showed loss of MLH-1 and PMS-2 mismatch repair proteins. The patient did not fulfil the criteria for HNPCC. Only 5 other cases of primary colonic LEL carcinoma have been described previously and only one case appears to have an unequivocal association with EBV. In addition, one of the cases was encountered in a HNPCC patient. This is an unusual morphologic variant of a microsatellite unstable tumour with a LEL pattern, not ass...

Benefit of Bone Drug in Prostate Cancer in Doubt

MedPage Today Public Health — Tue, 07 Feb 2012 13:00:00 +0100

WASHINGTON (MedPage Today) -- FDA reviewers have questioned whether expanding the indication for Amgen's denosumab (Xgeva) to prevent the spread of prostate cancer to the bones would provide much added benefit. (Source: MedPage Today Public Health)

News From The Journal Of Clinical Investigation: Feb. 6, 2012

Health News from Medical News Today — Tue, 07 Feb 2012 10:00:00 +0100

IMMUNOLOGY: How a stomach-colonizing bacterium protects against asthma The bacterium Helicobacter pylori can be found colonizing the stomach lining of almost half the world's population. Although persistent infection with Helicobacter pylori increases an individual's risk of developing stomach cancer, it also decreases their risk of developing asthma. A team of researchers led by Anne Muller, at the University of ZÃ¼rich, Switzerland, has now identified a cellular mechanism by which persistent infection with Helicobacter pylori protects mice from developing allergic asthma... (Source: Health News from Medical News Today)

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Increased Risk Of Fatal Side Effects From 3 'Targeted' Cancer Drugs

Health News from Medical News Today — Tue, 07 Feb 2012 09:00:00 +0100

Treatment with three relatively new "targeted" cancer drugs has been linked to a slightly elevated chance of fatal side effects, according to a new analysis led by scientists at Dana-Farber Cancer Institute. They added that the risk remains low, but should be taken into account by physicians and patients. The incidence of fatal complications was 1.5 percent in patients who received any of the three drugs, which block the vascular endothelial growth factor (VEGF) tyrosine kinase receptors in cancer cells, according to the study published February 6 in the Journal of Clinical Oncology... (Source: Health News from Medical News Today)

New Prostate Cancer Drug Target Identified

Health News from Medical News Today — Tue, 07 Feb 2012 09:00:00 +0100

Research led by Wanguo Liu, PhD, Associate Professor of Genetics at LSU Health Sciences Center New Orleans, has identified a new protein critical to the development and growth of prostate cancer. The findings are published online in the Early Edition of Proceedings of the National Academy of Sciences, available the week of February 6, 2012. Dr. Liu and his team discovered a protein called ARD1 which is involved with the male hormone, androgen, and its receptor. Prostate cancer is a hormone-regulated disease and the main hormone is androgen... (Source: Health News from Medical News Today)

A Particular Breast Cancer Subtype May Respond To Drugs Targeting Chromosomal Instability

Health News from Medical News Today — Tue, 07 Feb 2012 09:00:00 +0100

Another layer in breast cancer genetics has been peeled back. A team of researchers at Jefferson's Kimmel Cancer Center (KCC) led by Richard G. Pestell, M.D., PhD., FACP, Director of the KCC and Chair of the Department of Cancer Biology, have shown in a study published online in the Journal of Clinical Investigation that the oncogene cyclin D1 may promote a genetic breakdown known as chromosomal instability (CIN). CIN is a known, yet poorly understood culprit in tumor progression... (Source: Health News from Medical News Today)

More Accurate Diagnosis Of Genetic Mutations Expected Using New Virtual Tool

Health News from Medical News Today — Tue, 07 Feb 2012 09:00:00 +0100

DNA sequencing to detect genetic mutations can aid in the diagnosis and selection of treatment for cancer. Current methods of testing DNA samples, Sanger sequencing and pyrosequencing, occasionally produce complex results that can be difficult or impossible to interpret. Scientists at the Johns Hopkins University School of Medicine have developed a free software program, Pyromaker, that can more accurately identify such complex genetic mutations... (Source: Health News from Medical News Today)

Key To Immune Cell's 'internal Guidance' System Discovered

Health News from Medical News Today — Tue, 07 Feb 2012 09:00:00 +0100

University of British Columbia researchers have discovered the molecular pathway that enables receptors inside immune cells to find, and flag, fragments of pathogens trying to invade a host. The discovery of the role played by the molecule CD74 could help immunologists investigate treatments that offer better immune responses against cancers, viruses and bacteria, and lead to more efficient vaccines. The findings are published in this week's edition of Nature Immunology... (Source: Health News from Medical News Today)

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The final frontier in the war on cancer

Telegraph Health — Tue, 07 Feb 2012 08:28:48 +0100

Frustrated by glacial progress, the US has turned to physicists to fight the disease, reveals Paul Davies. (Source: Telegraph Health)

No Breast Cancer Protections From Soy Isoflavone Supplements

Health News from Medical News Today — Tue, 07 Feb 2012 08:00:00 +0100

Soy isoflavone supplements did not decrease breast cancer cell proliferation in a randomized clinical trial, according to a study published in Cancer Prevention Research, a journal of the American Association for Cancer Research. Lead researcher Seema A. Khan, M.D., professor of surgery at the Robert H. Lurie Comprehensive Cancer Center of Northwestern University, said the results of this study are consistent with the findings of previous studies that were designed to test cancer prevention benefits of dietary supplements. "Simply put, supplements are not food... (Source: Health News from Medical News Today)

Reviewing Ways To Balance The Benefits Of Oxaliplatin With Its Side Effects When Treating Colon Cancer

Health News from Medical News Today — Tue, 07 Feb 2012 08:00:00 +0100

The drug oxaliplatin is a major reason the prognosis for metastatic colon cancer has gone from an expected survival of several months to a couple years. Unfortunately, the drug can also carry with it debilitating neurological side effects, which generally start as the sensation of pins and needles in fingers and toes and can leave patients unable to walk or dress independently... (Source: Health News from Medical News Today)

Breakthroughs Demonstrate Importance Of Targeted Therapies For Lung Cancer

Health News from Medical News Today — Tue, 07 Feb 2012 08:00:00 +0100

Different kinds of lung cancer behave in different ways, suggesting they are fundamentally different diseases. According to a University of Colorado Cancer Center study published in Cancer, the official journal of the American Cancer Society, different subgroups of non-small cell lung cancer (NSCLC) show distinct patterns of spread in the body... (Source: Health News from Medical News Today)

'Biopsy In A Blood Test' - Effective New Diagnostic For Cancer

Health News from Medical News Today — Tue, 07 Feb 2012 08:00:00 +0100

Scientists from The Scripps Research Institute, Scripps Health, and collaborating cancer physicians have successfully demonstrated the effectiveness of an advanced blood test for detecting and analyzing circulating tumor cells (CTCs) - breakaway cells from patients' solid tumors - from cancer patients. The findings, reported in five new papers, show that the highly sensitive blood analysis provides information that may soon be comparable to that from some types of surgical biopsies... (Source: Health News from Medical News Today)

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Study Identifies Molecular Switch That Allows Melanoma To Resist Therapy

Health News from Medical News Today — Tue, 07 Feb 2012 08:00:00 +0100

The National Cancer Institute (NCI) estimates that as many as one in 51 men and women will be diagnosed with melanoma - the deadliest form of skin cancer - at some point during their lifetimes. A research team led by Ze'ev Ronai, Ph.D. at Sanford-Burnham Medical Research Institute (Sanford-Burnham) is working to unravel the molecular mechanisms underlying the development and progression of this disease in hopes of improving prevention and treatment strategies... (Source: Health News from Medical News Today)

Silver Compounds Found To Be Toxic To Cancer

Health News from Medical News Today — Tue, 07 Feb 2012 08:00:00 +0100

The internet is awash with stories of how silver can be used to treat cancer. Now, lab tests have shown that it is as effective as the leading chemotherapy drug - and may have fewer side-effects. Results from the study at the University of Leeds, published in Dalton Transactions, show that particular silver compounds are as toxic to cancer cells as the platinum-based drug Cisplatin, which is widely used to treat a range of cancers. But the crucial difference is that silver is thought to be much less toxic to healthy human cells, and in some cases, can be beneficial... (Source: Health News from Medical News Today)

Oncology Translational Imaging For Early Phase Anticancer Drug Development - Conference, 14-15 March 2012, London

Health News from Medical News Today — Tue, 07 Feb 2012 08:00:00 +0100

Join SMi at their 8th annual Imaging in Cancer Drug Development conference to be held on the 14th & 15th March 2012 in London, that promises to be interactive and informative. With an increasing verity of imaging modalities available and each of them offering benefits at different stages and in different ways, there is a great deal of benefit that can be gained from their implementation... (Source: Health News from Medical News Today)

SPACE: Addition of sorafenib delayed progression in intermediate HCC

HemOncToday.com — Tue, 07 Feb 2012 07:24:00 +0100

(Source: HemOncToday.com)

Avoid Window Seats to Cut Risk for In-Flight Blood Clots: Study

MedicineNet Cancer General — Tue, 07 Feb 2012 07:00:00 +0100

Title: Avoid Window Seats to Cut Risk for In-Flight Blood Clots: StudyCategory: Health NewsCreated: 2/7/2012 10:05:00 AMLast Editorial Review: 2/7/2012 (Source: MedicineNet Cancer General)

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Antidepressants May Not Raise Suicide Risk in Youth: Study

MedicineNet Cancer General — Tue, 07 Feb 2012 07:00:00 +0100

Title: Antidepressants May Not Raise Suicide Risk in Youth: StudyCategory: Health NewsCreated: 2/6/2012 6:06:00 PMLast Editorial Review: 2/7/2012 (Source: MedicineNet Cancer General)

Certain Cancer Drugs May Have Fatal Side Effects: Analysis

MedicineNet Cancer General — Tue, 07 Feb 2012 07:00:00 +0100

Title: Certain Cancer Drugs May Have Fatal Side Effects: AnalysisCategory: Health NewsCreated: 2/6/2012 6:06:00 PMLast Editorial Review: 2/7/2012 (Source: MedicineNet Cancer General)

Health Highlights: Feb. 6, 2012

MedicineNet Cancer General — Tue, 07 Feb 2012 07:00:00 +0100

Title: Health Highlights: Feb. 6, 2012Category: Health NewsCreated: 2/6/2012 2:05:00 PMLast Editorial Review: 2/7/2012 (Source: MedicineNet Cancer General)

Diagnosis and treatment of diffuse large B-cell lymphoma.

Swiss Medical Weekly — Tue, 07 Feb 2012 05:36:02 +0100

Authors: Mey U, Hitz F, Lohri A, Pederiva S, Taverna C, Tzankov A, Meier O, Yeow K, Renner C Abstract Diffuse large B-cell lymphoma (DLBCL) is the most frequently-occurring type of malignant lymphoma in the Western world. It has an aggressive natural history, with a median survival of less than one year if left untreated. Immunochemotherapy regimens, consisting of the anti-CD20 antibody rituximab typically in combination with cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP), are currently the treatment backbone. Despite remarkable progress in improving patient survival, clinical outcomes are still unsatisfactory for certain subsets of patients, including the elderly and very elderly and those with highly aggressive disease. This review outlines some of the current ...

UT MD Anderson, Texas A&M Team Up to Treat Canine Lymphoma

M. D. Anderson Cancer Center - News Releases — Tue, 07 Feb 2012 05:00:00 +0100

New therapy combination prolongs survival in dogs and furthers research for human trials (Source: M. D. Anderson Cancer Center - News Releases)

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UT MD Anderson Regional Care Center in the Bay Area Now Offers Surgery

M. D. Anderson Cancer Center - News Releases — Tue, 07 Feb 2012 05:00:00 +0100

Surgical Oncologist Returns to Area, Bringing Specialized Skills, Experience (Source: M. D. Anderson Cancer Center - News Releases)

A National Survey of the Availability of Intensity-Modulated Radiation Therapy and Stereotactic Radiosurgery in Canada

Radiation Oncology — Tue, 07 Feb 2012 05:00:00 +0100

Conclusions: The survey showed a growing adoption of IMRT and SRS in Canada, although the latter was available in less than half of responding centers. Barriers to implementation differed for IMRT compared to SRS. Enhancing human resources is an important consideration in the implementation of new RT technologies, due to the multidisciplinary nature of the planning and treatment process. (Source: Radiation Oncology)

Long‐term psychological distress in women at risk for hereditary breast cancer adhering to regular surveillance: a risk profile

Psycho-Oncology — Tue, 07 Feb 2012 05:00:00 +0100

Conclusion: On the basis of the identified risk profile, it is possible to identify vulnerable women at an early stage, who then may be offered additional and individually tailored support. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Psycho-Oncology)

Scientific rigour in psycho‐oncology trials: why and how to avoid common statistical errors

Psycho-Oncology — Tue, 07 Feb 2012 05:00:00 +0100

ConclusionsTo increase the scientific rigour in psycho‐oncology, researchers should involve a biostatistician from the beginning of the study and should commit to continuing education on best practices in the fields of statistics and reporting. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Psycho-Oncology)

Initial testing (stage 1) of the cyclin dependent kinase inhibitor SCH 727965 (dinaciclib) by the pediatric preclinical testing program

Pediatric Blood and Cancer — Tue, 07 Feb 2012 05:00:00 +0100

ConclusionsSCH 727965 shows an interesting pattern of activity suggesting its potential applicability against selected childhood cancers, particularly leukemias. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer)

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Hemophagocytic lymphohistiocytosis associated with necrotizing enterocolitis in premature newborns

Pediatric Blood and Cancer — Tue, 07 Feb 2012 05:00:00 +0100

AbstractHemophagocytic lymphohistiocytosis (HLH) is a systemic disease resulting from the excessive release of inflammatory cytokines by macrophages under prolonged antigenic stimulation. If untreated, it leads to multiorgan failure and death. Necrotizing enterocolitis (NEC) has not previously been associated with HLH. Here we report four preterm infants who were diagnosed with HLH associated with NEC. Two patients received chemotherapy and one survived. The other two infants succumbed to multiorgan failure. These results suggest that NEC may be a common clinical manifestation of HLH in premature neonates. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer)

Evaluation of arsenic trioxide by the pediatric preclinical testing program with a focus on Ewing sarcoma

Pediatric Blood and Cancer — Tue, 07 Feb 2012 05:00:00 +0100

AbstractArsenic trioxide was tested against the PPTP in vitro panel (1.0 nM to 10 µM) and against the PPTP Ewing sarcoma in vivo panel administered intraperitoneally at a dose of 2.5 mg/kg daily × 5 per week for a planned treatment duration of 3 weeks. Arsenic trioxide showed a median relative IC50 value of 0.9 µM, with Ewing sarcoma cell lines having IC50 values similar to those of the remaining PPTP cell lines. Arsenic trioxide did not induce significant differences in EFS distribution compared to control in any of the Ewing sarcoma xenografts studied, and no objective responses were observed. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer)

Improving the histopathologic diagnosis of pediatric malignancies in a low‐resource setting by combining focused training and telepathology strategies

Pediatric Blood and Cancer — Tue, 07 Feb 2012 05:00:00 +0100

ConclusionsBrief, focused training in pediatric cancer histopathology can improve diagnostic accuracy. Dynamic and static telepathology analyses are equally effective for diagnostic review. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer)

Laparoscopic versus Open Colectomy for Colon Cancer in an Older Population: A Cohort Study

World Journal of Surgical Oncology — Tue, 07 Feb 2012 05:00:00 +0100

Conclusions: In this older population, laparoscopic colectomy practice patterns were associated with factors which likely correlate with tertiary referral centers. Although short-term and long-term survival are comparable, laparoscopic colectomy offers shorter hospitalizations and less intensive care. (Source: World Journal of Surgical Oncology)

Risk of Death From Certain Breast Cancers May Rise With Age

The Doctors Lounge - Oncology — Tue, 07 Feb 2012 05:00:00 +0100

Research focused on estrogen-sensitive tumors; undertreatment might play a role, expert says (Source: The Doctors Lounge - Oncology)

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Immunohistochemical discrimination of wild-type EGFR from EGFRvIII in fixed tumour specimens using anti-EGFR mAbs ICR9 and ICR10

British Journal of Cancer AOP — Tue, 07 Feb 2012 05:00:00 +0100

Authors: H Modjtahedi, S A Khelwatty, R S Kirk, A M Seddon, S Essapen, C A Del Vecchio, A J Wong & S Eccles (Source: British Journal of Cancer AOP)

Socioeconomic position, treatment, and survival of non-Hodgkin lymphoma in Denmark – a nationwide study

British Journal of Cancer AOP — Tue, 07 Feb 2012 05:00:00 +0100

Socioeconomic position, treatment, and survival of non-Hodgkin lymphoma in Denmark – a nationwide study British Journal of Cancer advance online publication, February 7, 2012. doi:10.1038/bjc.2012.3 Authors: B L Frederiksen, S O Dalton, M Osler, M Steding-Jessen & P de Nully Brown (Source: British Journal of Cancer AOP)

Concentrations of IGF-I and IGFBP-3 and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition

British Journal of Cancer AOP — Tue, 07 Feb 2012 05:00:00 +0100

Authors: S Rohrmann, V A Grote, S Becker, S Rinaldi, A Tjønneland, N Roswall, H Grønbæk, K Overvad, M C Boutron-Ruault, F Clavel-Chapelon, A Racine, B Teucher, H Boeing, D Drogan, V Dilis, P Lagiou, A Trichopoulou, D Palli, G Tagliabue, R Tumino, P Vineis, A Mattiello, L Rodríguez, E J Duell, E Molina-Montes, M Dorronsoro, J-M Huerta, E Ardanaz, S Jeurnink, P H M Peeters, B Lindkvist, D Johansen, M Sund, W Ye, K-T Khaw, N J Wareham, N E Allen, F L Crowe, V Fedirko, M Jenab, D S Michaud, T Norat, E Riboli, H B Bueno-de-Mesquita & R Kaaks (Source: British Journal of Cancer AOP)

Acquisition of EMT phenotype in the gefitinib-resistant cells of a head and neck squamous cell carcinoma cell line through Akt/GSK-3β/snail signalling pathway

British Journal of Cancer AOP — Tue, 07 Feb 2012 05:00:00 +0100

Acquisition of EMT phenotype in the gefitinib-resistant cells of a head and neck squamous cell carcinoma cell line through Akt/GSK-3β/snail signalling pathway British Journal of Cancer advance online publication, February 7, 2012. doi:10.1038/bjc.2012.24 Authors: S Maseki, K Ijichi, H Tanaka, M Fujii, Y Hasegawa, T Ogawa, S Murakami, E Kondo & H Nakanishi (Source: British Journal of Cancer AOP)

Direct improvement of quality of life using a tailored quality of life diagnosis and therapy pathway: randomised trial in 200 women with breast cancer

British Journal of Cancer AOP — Tue, 07 Feb 2012 05:00:00 +0100

Authors: M Klinkhammer-Schalke, M Koller, B Steinger, C Ehret, B Ernst, J C Wyatt, F Hofstädter & W Lorenz (Source: British Journal of Cancer AOP)

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Prognostic significance of gamma-glutamyltransferase in patients with endometrial cancer: a multi-centre trial

British Journal of Cancer AOP — Tue, 07 Feb 2012 05:00:00 +0100

Authors: V Seebacher, S Polterauer, C Grimm, J Rahhal, G Hofstetter, E-M Bauer, H Husslein, H Leipold, C Marth, A Reinthaller & N Concin (Source: British Journal of Cancer AOP)

Circulating sphingosine-1-phosphate and erythrocyte sphingosine kinase-1 activity as novel biomarkers for early prostate cancer detection

British Journal of Cancer AOP — Tue, 07 Feb 2012 05:00:00 +0100

Authors: J Nunes, M Naymark, L Sauer, A Muhammad, H Keun, J Sturge, J Stebbing, J Waxman & D Pchejetski (Source: British Journal of Cancer AOP)

Pre-treatment lactate dehydrogenase levels as predictor of efficacy of first-line bevacizumab-based therapy in metastatic colorectal cancer patients

British Journal of Cancer AOP — Tue, 07 Feb 2012 05:00:00 +0100

Authors: M Scartozzi, R Giampieri, E Maccaroni, M Del Prete, L Faloppi, M Bianconi, E Galizia, C Loretelli, L Belvederesi, A Bittoni & S Cascinu (Source: British Journal of Cancer AOP)

Malignant mesotheliomas in former miners and millers of crocidolite at Wittenoom (Western Australia) after more than 50 years follow-up

British Journal of Cancer AOP — Tue, 07 Feb 2012 05:00:00 +0100

Authors: G Berry, A Reid, P Aboagye-Sarfo, N H de Klerk, N J Olsen, E Merler, P Franklin & A W Musk (Source: British Journal of Cancer AOP)

A phase 1 trial of recombinant human IL-21 in combination with cetuximab in patients with metastatic colorectal cancer

British Journal of Cancer AOP — Tue, 07 Feb 2012 05:00:00 +0100

Authors: N Steele, A Anthony, M Saunders, B Esmarck, E Ehrnrooth, P E G Kristjansen, A Nihlén, L T Hansen & J Cassidy (Source: British Journal of Cancer AOP)

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Metabolic profiles essential for personalizing cancer therapy

EurekAlert! - Cancer — Tue, 07 Feb 2012 05:00:00 +0100

(Cell Press) One way to tackle a tumor is to take aim at the metabolic reactions that fuel their growth. But a report in the February Cell Metabolism, a Cell Press Publication, shows that one metabolism-targeted cancer therapy will not fit all. That means that metabolic profiling will be essential for defining each cancer and choosing the best treatment accordingly, the researchers say. (Source: EurekAlert! - Cancer)

Toxicities effects of pharmaceutical, olive mill and textile wastewaters before and after degradation by Pseudomonas putida mt-2

Cancer Cell International — Tue, 07 Feb 2012 05:00:00 +0100

Conclusion: Toxicity was totally removed when mice were treated by the bio remediated effluent. This indicates that P. putida was able to completely detoxify the toxic industrial effluent. (Source: Cancer Cell International)

Forkhead box transcription factor, forkhead box A1, shows negative association with lymph node status in endometrial cancer, and represses cell proliferation and migration of endometrial cancer cells

Cancer Science — Tue, 07 Feb 2012 05:00:00 +0100

Endometrial cancer is the most common malignancy of the female genital tract and is associated with poor prognosis. It is primarily a hormone‐dependent cancer that is regulated by steroid hormones, including estrogen and progesterone. Forkhead box A1 (FOXA1) is a member of the forkhead box transcription factor family and functions as a pioneer factor in estrogen receptor (ER)‐positive breast cancer. In the present study, we investigated the expression of FOXA1 in endometrial cancers by immunohistochemical analysis. Nuclear immunoreactivity for FOXA1 was detected in 40 of 109 cases (37%), and was found to be negatively associated with lymph node status (P = 0.033). In ER‐positive Ishikawa endometrial cancer cells, small interfering RNA‐mediated downregulation of FOXA1 promoted cel...

The association between Toll-like receptor 2 single-nucleotide polymorphisms and hepatocellular carcinoma susceptibility

BMC Cancer — Tue, 07 Feb 2012 05:00:00 +0100

Conclusions: These results suggested that TLR2 rs3804099 C/T and rs3804100 C/T polymorphisms were closely associated with HCC. In addition, the haplotypes composed of these two TLR2 synonymous SNPs have stronger effects on the susceptibility of HCC. (Source: BMC Cancer)

Increased serum sTRAIL levels were correlated with survival in bevacizumab-treated metastatic colon cancer

BMC Cancer — Tue, 07 Feb 2012 05:00:00 +0100

Conclusions: Serum sTRAIL levels might be a useful predictor of prognosis in metastatic colon cancer, in the early evaluation stages following bevacizumab treatment. (Source: BMC Cancer)

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Neck control after definitive radiochemotherapy without planned neck dissection in node-positive head and neck cancers

BMC Cancer — Tue, 07 Feb 2012 05:00:00 +0100

Conclusions: The neck failure rate after definitive radiochemotherapy without planned neck dissection was 22%. Two-thirds of these were successfully salvaged with neck dissection and the ultimate neck control rate was 92%. Our results suggest that planned neck dissection might not be necessary in patients with complete response of primary site, no evidence of residual lesion >1.5 cm, or no necrotic lymph nodes at the 1-2 months follow-up evaluation after radiotherapy. (Source: BMC Cancer)

Peripheral T-lymphocytes express WNT7A and its restoration in leukemia-derived lymphoblasts inhibits cell proliferation

BMC Cancer — Tue, 07 Feb 2012 05:00:00 +0100

Conclusions: To our knowledge, this is the first report evidencing quantitatively decreased WNT7A levels in leukemia-derived cells and that WNT7A restoration in T-lymphocytes inhibits cell proliferation. In addition, our results also support the possible function of WNT7A as a tumor suppressor gene as well as a therapeutic tool. (Source: BMC Cancer)

Anti-apoptotic gene transcription signature of salivary gland neoplasms

BMC Cancer — Tue, 07 Feb 2012 05:00:00 +0100

Conclusion: In conclusion, we show an anti-apoptotic gene expression profile in salivary neoplasms in association with p53 staining, but independent of cell proliferation and tumour size. (Source: BMC Cancer)

Response: Re: Inconsistencies in Findings from the Early Lung Cancer Action Project Studies of Lung Cancer Screening

JNCI — Tue, 07 Feb 2012 05:00:00 +0100

(Source: JNCI)

Re: Inconsistencies in Findings from the Early Lung Cancer Action Project Studies of Lung Cancer Screening

JNCI — Tue, 07 Feb 2012 05:00:00 +0100

(Source: JNCI)

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Re: Inconsistencies in Findings From the Early Lung Cancer Action Project Studies of Lung Cancer Screening

JNCI — Tue, 07 Feb 2012 05:00:00 +0100

(Source: JNCI)

Genome-Wide Association Study of Classical Hodgkin Lymphoma and Epstein-Barr Virus Status-Defined Subgroups

JNCI — Tue, 07 Feb 2012 05:00:00 +0100

Conclusion Overall, these results provide strong evidence that EBV status is an etiologically important classification of cHL and also suggest that some components of the pathological process are common to both EBV-positive and EBV-negative patients. (Source: JNCI)

Effect of KRAS Oncogene Substitutions on Protein Behavior: Implications for Signaling and Clinical Outcome

JNCI — Tue, 07 Feb 2012 05:00:00 +0100

Conclusions Not all mutant KRas proteins affect patient survival or downstream signaling in a similar way. The heterogeneous behavior of mutant KRas proteins implies that therapeutic interventions may need to take into account the specific mutant KRas expressed by the tumor. (Source: JNCI)

Comparative Effectiveness of Oxaliplatin vs Non-Oxaliplatin-containing Adjuvant Chemotherapy for Stage III Colon Cancer

JNCI — Tue, 07 Feb 2012 05:00:00 +0100

Conclusion The addition of oxaliplatin to 5-FU appears to be associated with better survival among patients receiving adjuvant colon cancer treatment in the community. (Source: JNCI)

MedWorm: Cancer & Oncology

Multiengine Speech Processing Using SNR Estimator in Variable Noisy Environments

Visual Field Loss Morphology in High- and Normal-Tension Glaucoma

Microarray Analyses of Genes Differentially Expressed by Diet (Black Beans and Soy Flour) during Azoxymethane-Induced Colon Carcinogenesis in Rats

Electrical Properties of Rapidly Annealed Ir and Ir/Au Schottky Contacts on n-Type InGaN

Effects of Brugmansia arborea Extract and Its Secondary Metabolites on Morphine Tolerance and Dependence in Mice

Design and Optimization of a Millimetre Wave Compact Folded Magic-T

Spectral Distortion in Lossy Compression of Hyperspectral Data

Factors That Influence HIV Risk among Hispanic Female Immigrants and Their Implications for HIV Prevention Interventions

Seasonal Changes in Testes Vascularisation in the Domestic Cat (Felis domesticus): Evaluation of Microvasculature, Angiogenic Activity, and Endothelial Cell Expression

Contents

Editorial Board

Repeat flexible sigmoidoscopy increases colorectal cancer detection rate

Living with rotationplasty—Quality of life in rotationplasty patients from childhood to adulthood

Does preoperative therapy optimize outcomes in patients with resectable pancreatic cancer?

FDA Grants Imatinib (Gleevec) Full Approval for Adjuvant Treatment of GIST

The results of treatment of children with metastatic Wilms tumours (WT) in an African setting: Do liver metastases have a negative impact on survival?

Antiparkinsonian Mechanism of Electroconvulsive Therapy in MPTP-Lesioned Non-Human Primates

Evaluation of Neurodegeneration in a Mouse Model of Infantile Batten Disease by Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy

APOE-Mimetic Peptides Reduce Behavioral Deficits, Plaques and Tangles in Alzheimer's Disease Transgenics

The Gastrin-Releasing Peptide Receptor as a Marker of Dysplastic Alterations in Cervical Epithelial Cells

Expression of Epidermal Growth Factors, erbBs, in the Nasal Mucosa of Patients with Chronic Hypertrophic Rhinitis

Planned Neck Dissection before Combined Chemoradiation in Organ Preservation Protocol for N2-N3 of Supraglottic or Hypopharyngeal Carcinoma

Leptin in Anorexia and Cachexia Syndrome

MOfinder: A Novel Algorithm for Detecting Overlapping Modules from Protein-Protein Interaction Network

Targeting HLA class I expression to increase tumor immunogenicity

The impact of lung cancer on patients and carers.

For Personalizing Cancer Therapy, Metabolic Profiles Are Essential

Early Signs Of Disease Detected By Metabolic 'Breathalyzer'

Key Finding In Stem Cell Self-Renewal

More Accurate Diagnosis, Prognosis In Challenging Breast Cancer Cases Provided By PET Techniques

Patient Sensitivity To Important Drug Target In Deadly Brain Cancer Predicted

Zinc Control Mechanisms Could Be Key To Aggressive Breast Cancer Treatments

Women Born To Older Mothers Have A Higher Risk Of Developing Breast Cancer

Men with low-risk prostate cancer may benefit from dutasteride, active surveillance

After Outcry, Karen Handel Resigns From Komen

Top9ColCanRiskFactors

basics of lymphedema

Overexpression of DNA damage-induced 45 alpha gene contributes to esophageal squamous cell cancer by promoter hypomethylation

Improving adherence to surveillance and screening recommendations for people with colorectal cancer and their first degree relatives: A randomized controlled trial

The role and function of cadherins in the mammary gland

Key signaling nodes in mammary gland development and cancer: Smad signal integration in epithelial cell plasticity

Research partnership to improve treatments for cancer patients

Prognostic value of bcl-2 and bax tumor cell expression in patients with non muscle-invasive bladder cancer receiving bacillus calmette-guerin immunotherapy.

Pilot study on evaluation of any correlation between MR perfusion (K(trans)) and diffusion (apparent diffusion coefficient) parameters in brain tumors at 3 Tesla.

Diffuse pulmonary uptake on FDG-PET with normal CT diagnosed as intravascular large B-cell lymphoma: a case report and a discussion of the causes of diffuse FDG uptake in the lungs.

The emergence of diagnostic imaging technologies in breast cancer: discovery, regulatory approval, reimbursement, and adoption in clinical guidelines.

Atypical lipomatous tumor with unusual extensive metaplastic ossification.

CT-based quantitative SPECT for the radionuclide (201)Tl: experimental validation and a standardized uptake value for brain tumour patients.

Risk of Death From Certain Breast Cancers May Rise With Age

Komen official resigns over Planned Parenthood dispute

Perception versus Reality: The Measuring of Pleural Fluid pH in the United States

Topical Imiquimod 5% Cream for Pediatric Plaque Morphea: A Prospective, Multiple-Baseline, Open-Label Pilot Study

Systolic Heart Function, Kidney Filtration and the Number of Coronary Atherosclerotic Plaques in Lean and Overweight Patients

High Incidence of Internal Malignancy in Papuloerythroderma of Ofuji: A Case Series from Japan

Diagnosis and Treatment of Hyper-Delayed Graft Function after Renal Transplantation

Feasibility and Safety of Early Removal of Incisional Dressings following Thoracic Surgery

Evolution of Sensory Development – Lessons from the Lateral Line

Alcohol Consumption and Its Relation to Visceral and Subcutaneous Adipose Tissues in Healthy Male Koreans

Cholesterol Is Associated with the Presence of a Lipid Core in Carotid Plaque of Asymptomatic, Young-to-Middle-Aged African Americans with and without HIV Infection and Cocaine Use Residing in Inner-City Baltimore, Md., USA

Genetic Polymorphisms of FcγRIIa and FcγRIIIa Are Not Predictive of Clinical Outcomes after Cetuximab plus Irinotecan Chemotherapy in Patients with Metastatic Colorectal Cancer

Cochlear Implantation in Posttraumatic Bilateral Temporal Bone Fracture

Differences in Survival between Patients with Dementia with Lewy Bodies and Patients with Alzheimer's Disease - Measured from a Fixed Cognitive Level

Trends in the Incidence of Biopsy-Proven Glomerular Diseases in the Adult Population in Central Poland in the Years 1990-2010

Older Age Worsens Breast Cancer Prognosis (CME/CE)

Breast cancer kills older women more often

Komen VP quits after Planned Parenthood funds restored

Ovarian Cancer Screening Common Despite Lack of Proof (CME/CE)

Komen Official Quits After Controversy

Roche breast cancer drug gets FDA priority review

Breast Cancer Drug May Weaken Bones, Study Finds

Navigating Treatment Decisions

Well Blog: A Better Way to Spend Breast Cancer Funds?

Komen VP steps down after Planned Parenthood flap

Komen official quits breast cancer charity over dispute

Komen official quits over Planned Parenthood

Official quits breast cancer charity over funding dispute

Official quits breast cancer charity over dispute

What is Palliative Care?

For physicians: VEGF tyrosine kinase inhibitor treatment risks