MedWorm: Chemistry Top 20

CD8+ T-Cell Deficiency, Epstein-Barr Virus Infection, Vitamin D Deficiency, and Steps to Autoimmunity: A Unifying Hypothesis

International Journal of Photoenergy — Tue, 24 Jan 2012 18:18:57 +0100

CD8+ T-cell deficiency is a feature of many chronic autoimmune diseases, including multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus, Sjögren's syndrome, systemic sclerosis, dermatomyositis, primary biliary cirrhosis, primary sclerosing cholangitis, ulcerative colitis, Crohn's disease, psoriasis, vitiligo, bullous pemphigoid, alopecia areata, idiopathic dilated cardiomyopathy, type 1 diabetes mellitus, Graves' disease, Hashimoto's thyroiditis, myasthenia gravis, IgA nephropathy, membranous nephropathy, and pernicious anaemia. It also occurs in healthy blood relatives of patients with autoimmune diseases, suggesting it is genetically determined. Here it is proposed that this CD8+ T-cell deficiency underlies the development of chronic autoimmune dise...

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Walnuts pack the biggest punch when it comes to healthy nuts

RSC News — Sun, 15 Jan 2012 07:04:44 +0100

Walnuts have been crowned king of nuts when it comes to health benefits, according to scientists. (Source: RSC News)

Optimization of solid-phase extraction and liquid chromatography-tandem mass spectrometry for the determination of domoic acid in seawater, phytoplankton, and mammalian fluids and tissues.

Analytica Chimica Acta — Mon, 23 Jan 2012 01:13:11 +0100

Authors: Wang Z, Maucher-Fuquay J, Fire SE, Mikulski CM, Haynes B, Doucette GJ, Ramsdell JS Abstract We previously reported a solid-phase extraction (SPE) method for determination of the neurotoxin domoic acid (DA) in both seawater and phytoplankton by liquid chromatography-tandem mass spectrometry (LC-MS/MS) with the purpose of sample desalting without DA pre-concentration. In the present study, we optimized the SPE procedure with seawater and phytoplankton samples directly acidified with aqueous formic acid without addition of organic solvents, which allowed sample desalting and also 20-fold pre-concentration of DA in seawater and phytoplankton samples. In order to reduce MS contamination, a diverter valve was installed between LC and MS to send the LC eluant to waste, except for...

A dicarbazole-triazine hybrid bipolar host material for highly efficient green phosphorescent OLEDs

RSC - J. Mater. Chem. latest articles — Tue, 24 Jan 2012 18:17:11 +0100

J. Mater. Chem., 2012, Advance ArticleDOI: 10.1039/C2JM14686J, PaperChih-Hao Chang, Ming-Cheng Kuo, Wei-Chieh Lin, Yu-Ting Chen, Ken-Tsung Wong, Shu-Hua Chou, Ejabul Mondal, Raymond C. Kwong, Sean Xia, Tetsuya Nakagawa, Chihaya AdachiA dicarbazole-triazine bipolar host CzT with promising physical properties was utilized to achieve highly efficient yellowish-green phosphorescent OLEDs.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - J. Mater. Chem. latest articles)

Separation of Electrical and Optical Energy Gaps for Constructing Bipolar Organic Wide Bandgap Materials

RSC - Chem. Commun. latest articles — Fri, 03 Feb 2012 17:53:59 +0100

Chem. Commun., 2012, Accepted ManuscriptDOI: 10.1039/C2CC17682C, CommunicationYuguang Ma, Dehua Hu, Fangzhong Shen, He Liu, Ping Lu, Ying Lv, Dandan LiuElectrical and optical energy gaps separated strategy is put forward for the design of organic wide bandgap semiconductors. This new principle could achieve an optimization of wide bandgap (both high...The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Chem. Commun. latest articles)

Selective localization of Alzheimer's amyloid beta in membrane lateral compartments

RSC - Soft Matter latest articles — Fri, 03 Feb 2012 17:54:06 +0100

Soft Matter, 2012, Advance ArticleDOI: 10.1039/C2SM07185A, CommunicationMasamune Morita, Tsutomu Hamada, Yuiko Tendo, Takahiro Hata, Mun'delanji C. Vestergaard, Masahiro TakagiModel membrane systems revealed that lateral heterogeneity of the membrane mediates the localization of amyloid beta peptides in a peptide aggregation-dependent manner.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Soft Matter latest articles)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Immunogold Labeling-Induced Synergy Effect for Amplified Photoelectrochemical Immunoassay of Prostate-Specific Antigen

RSC - Chem. Commun. latest articles — Tue, 24 Jan 2012 18:17:05 +0100

Chem. Commun., 2012, Accepted ManuscriptDOI: 10.1039/C2CC17942C, CommunicationJing-Juan Xu, Wei-Wei Zhao, Xiao-Ya Dong, Jing Wang, Fenying Kong, Hong-Yuan ChenA synergy effect based photoelectrochemical immunoassay of prostate cancer marker (prostate-specific antigen, PSA) is successfully developed with the use of gold nanoparticle functionalized with horseradish peroxidase (HRP).The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Chem. Commun. latest articles)

Was 50th anniversary movie Dr No negative for nuclear?

RSC News — Sun, 15 Jan 2012 07:04:44 +0100

Nuclear energy is a vital part of the UK energy mix - but has its representation in popular culture added to public mistrust? (Source: RSC News)

Whistleblowers accuse FDA of spying, persecution

Chemistry World | Latest News — Fri, 03 Feb 2012 17:53:57 +0100

US FDA employees sue agency, saying they were subjected to secret surveillance for expressing safety concerns about medical devices (Source: Chemistry World | Latest News)

A newly developed highly selective ratiometric fluoride ion sensor: Spectroscopic, NMR and density functional studies

RSC - Analyst latest articles — Fri, 27 Jan 2012 18:02:43 +0100

Analyst, 2012, Advance ArticleDOI: 10.1039/C2AN16132J, PaperArabinda Mallick, Ujjal Kanti Roy, Basudeb Haldar, Sanjay PratiharA tailor-made anion sensor, 3,3[prime or minute]-bis(indolyl)-4-chlorophenylmethane, shows selectivity towards fluoride ions established by spectrophotometric based ratiometric response, NMR titrimetric study and DFT calculations.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)

Discovery of (S)-6-(3-Cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic Acid as a Hepatoselective Glucokinase Activator Clinical Candidate for Treating Type 2 Diabetes Mellitus

Journal of Medicinal Chemistry — Tue, 24 Jan 2012 12:54:02 +0100

Journal of Medicinal ChemistryDOI: 10.1021/jm2014887 (Source: Journal of Medicinal Chemistry)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Metastability in a bi-component hydrogel of thymine and 6-methyl-1,3,5-triazine-2,4-diamine: ultrasound induced vs. thermo gelation

RSC - Soft Matter latest articles — Sat, 21 Jan 2012 17:45:48 +0100

Soft Matter, 2012, Advance ArticleDOI: 10.1039/C2SM07225D, CommunicationBappaditya Roy, Partha Bairi, Arun K. NandiA bi-component hydrogel shows different stability; the ultrasound-induced gels breaks more quickly than the thermo gels and Ostwald ripening is the probable cause of the metastability.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Soft Matter latest articles)

Electrochemical genosensor array for the simultaneous detection of multiple high-risk human papillomavirus sequences in clinical samples.

Analytica Chimica Acta — Mon, 23 Jan 2012 01:12:41 +0100

Authors: Civit L, Fragoso A, Hölters S, Dürst M, O'Sullivan CK Abstract An electrochemical genosensor array for the simultaneous detection of three high-risk human papillomavirus (HPV) DNA sequences, HPV16, 18 and 45, exhibiting high sensitivity and selectivity is presented. The electrodes of a 4×4 array were modified via co-immobilization of a 1:100 (mol/mol) mixture of a thiolated probe and an oligoethyleneglycol-terminated bipodal thiol. Detection of synthetic and PCR products was carried out in a sandwich type format, with the target hybridized between a surface immobilized probe and a horseradish peroxidase-labelled secondary reporter probe. The detection limits obtained in the detection of each individual target were in the pM range, allowing the application of this sensor...

Streptococcus suis II immunoassay based on thorny gold nanoparticles and surface enhanced Raman scattering

RSC - Analyst latest articles — Fri, 27 Jan 2012 18:02:43 +0100

Analyst, 2012, Advance ArticleDOI: 10.1039/C2AN15997J, PaperKun Chen, Heyou Han, Zhihui LuoAn immunoassay based on surface enhanced Raman scattering spectroscopy (SERS) was developed to detect muramidase released protein (MRP) antibody against Streptococcus suis II utilizing thorny gold nanoparticles as SERS substrates.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)

Macular Hole Progression after Intravitreal Bevacizumab for Hemicentral Retinal Vein Occlusion

International Journal of Photoenergy — Tue, 31 Jan 2012 11:10:23 +0100

Macular edema secondary to retinal vein occlusion is commonly being treated with off-label intravitreal bevacizumab with good outcomes. A significant reduction in macular edema and improvement in visual acuity is seen following such a treatment with no serious adverse effects. In the reported case, a full-thickness macular hole was noticed one month after intravitreal bevacizumab for macular edema secondary to hemicentral retinal vein occlusion. On a detailed review of the pre- and postoptical coherence tomography scans, it was realized that there was a preexisting stage 2-3 macular hole which was masked by the hemorrhages and edema at the fovea and the macular hole had progressed following the injection. (Source: International Journal of Photoenergy)

Interaction of CYP3A4 with Bromoergocryptine [Protein Structure and Folding]

Journal of Biological Chemistry — Fri, 27 Jan 2012 05:00:00 +0100

Cytochrome P4503A4 (CYP3A4), a major human drug-metabolizing enzyme, is responsible for the oxidation and clearance of the majority of administered drugs. One of the CYP3A4 substrates is bromoergocryptine (BEC), a dopamine receptor agonist prescribed for the inhibition of prolactin secretion and treatment of Parkinson disease, type 2 diabetes, and several other pathological conditions. Here we present a 2.15 Å crystal structure of the CYP3A4-BEC complex in which the drug, a type I heme ligand, is bound in a productive mode. The manner of BEC binding is consistent with the in vivo metabolite analysis and identifies the 8′ and 9′ carbons of the proline ring as the primary sites of oxidation. The crystal structure predicts the importance of Arg212 and Thr224 for binding of the tripeptide...

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Studying ancient crop provenance: implications from δ(13) C and δ(15) N values of charred barley in a Middle Bronze Age silo at Ebla(NW Syria).

Rapid Communications in Mass Spectrometry : RCM — Mon, 09 Jan 2012 20:38:38 +0100

Authors: Fiorentino G, Caracuta V, Casiello G, Longobardi F, Sacco A Abstract The discovery of a storeroom full of barley and other cereals (L.9512) in the proto-historic site of Ebla has provided a unique opportunity to study the centralized storage system of the early city-state from a different perspective. Epigraphic evidence available within the site reveals a complex system of taxation which included gathering grain tributes from satellite sites and redistributing semi-finished products such as flour. In this paper, we intend to explore the possibilities of a combined approach to studying the storage system, based on estimated barley grain volumes and δ(13) C-δ(15) N analyses. This approach is used to distinguish between grain from different harvesting sites and to identify...

Reversible addition-fragmentation chain transfer polymerization in microemulsion

RSC - Chemical Society Reviews — Sun, 15 Jan 2012 07:03:14 +0100

Chem. Soc. Rev., 2012, Advance ArticleDOI: 10.1039/C2CS15275D, Tutorial ReviewJennifer M. O'DonnellThe mechanism of RAFT polymerization in microemulsion is discussed, including polymerization kinetics, polymer molecular weight and polydispersity, and particle size.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Chemical Society Reviews)

Direct SERS detection of contaminants in a complex mixture: rapid, single step screening for melamine in liquid infant formula

RSC - Analyst latest articles — Sun, 15 Jan 2012 07:03:06 +0100

Analyst, 2012, Advance ArticleDOI: 10.1039/C2AN15846A, CommunicationJordan F. Betz, Yi Cheng, Gary W. RubloffMelamine contamination of infant formula can be directly detected using a SERS substrate formed on the surface of a coin.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)

Synthesis and thermal behavior of chiral dimers: occurrence of highly frustrated and cholesteric liquid crystal phases

RSC - New J. Chem. latest articles — Tue, 24 Jan 2012 18:17:13 +0100

New J. Chem., 2012, Advance ArticleDOI: 10.1039/C2NJ21035E, PaperG. Shanker, C. V. YelamaggadOccurrence of chiral nematic and/or highly frustrated liquid crystal phases over a wide thermal range in newly synthesized nonsymmetric dimers derived from cholesterol and phenyl cinnamate segments has been reported.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - New J. Chem. latest articles)