MedWorm: Databases & Libraries

Handbook of Clinical Gender Medicine

Karger Publishers — Wed, 08 Feb 2012 15:49:10 +0100

(ISBN: 978-3-8055-9929-0) (Source: Karger Publishers)

MedWorm Sponsor Message: Find the best January Sales in the UK.

Retinal Diseases

Karger Publishers — Wed, 08 Feb 2012 15:49:10 +0100

ISBN: 978-3-8055-9990-0 (Source: Karger Publishers)

Mayo Clinic Study Finds Obesity Affects Severity of Symptoms in Fibromyalgia Patients

News from Mayo Clinic — Wed, 08 Feb 2012 12:49:50 +0100

One factor associated with fibromyalgia symptoms is a patient's weight, according to a Mayo Clinic study published this month in "Arthritis Care & Research." A higher rate of obesity in those who have fibromyalgia may be caused by a cycle of pain and physical inactivity. (Source: News from Mayo Clinic)

Pulmonary Bacterial Communities in Surgically Resected Noncystic Fibrosis Bronchiectasis Lungs Are Similar to Those in Cystic Fibrosis

Clinical and Developmental Immunology — Wed, 08 Feb 2012 11:20:54 +0100

Conclusions. Our data indicate significant diversity in the pulmonary bacterial community of both CF and non-CF bronchiectasis patients and suggest that this community is similar in surgically resected lungs of CF and non-CF bronchiectasis patients. (Source: Clinical and Developmental Immunology)

PubMed for Trainers in Chicago

The Cornflower — Tue, 07 Feb 2012 21:31:06 +0100

Register for a FREE hands-on PubMed for Trainers class provided by the staff of the National Library of Medicine Training Center (NTC)! Would you like to gain new skills, brush up on existing PubMed skills and collaborate with colleagues to help create an effective training strategy? Join us for three Adobe Connect distance education classes and a one-day in-person class at the University of Illinois at Chicago Library of Health Sciences in Chicago, IL. These hands-on classes will include 9 presentations created by the National Library of Medicine, interactive demonstrations, hands-on exercises and networking opportunities. Upon completion of all four sessions the course will be worth 15 hours of MLA CE credit. View the full announcement and register at: http://nnlm.gov/ntc/promos/PMT_Chi...

EDUCATION: Breezing Along with the RML -Wed. February 15, 2012 10:00 Mountain Time, 11:00 Central Time

Midcontinental Region News — Tue, 07 Feb 2012 17:46:09 +0100

Updates from : 1) Marty Magee on “Education Topics” and 2) Barb Jones will be hosting Catherine Craven, MLS, who has worked at Johns Hopkins in the clinical librarianship program. URL: https://webmeeting.nih.gov/mcr/ Equipment: connection to the Internet and a phone, Login: as a guest with your first and last name. Instructions to connect to the audio will show up once you’ve logged in. Captioning will be provided a few minutes before the hour. Questions to mmagee@unmc.edu. (mm) (Source: Midcontinental Region News)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

How Reading Books Fosters Language Development around the World

Computational Intelligence and Neuroscience — Tue, 07 Feb 2012 11:42:45 +0100

This article reviews research on the connections between language and later reading, environmental factors associated with language learning, and interventions developed in varied countries for encouraging book use by parents of young children. (Source: Computational Intelligence and Neuroscience)

Identifying effective behavioural models and behaviour change strategies underpinning preschool‐ and school‐based obesity prevention interventions aimed at 4–6‐year‐olds: a systematic review

Obesity Reviews — Tue, 07 Feb 2012 10:44:24 +0100

SummaryThe aim of this comprehensive systematic review was to identify the most effective behavioural models and behaviour change strategies, underpinning preschool‐ and school‐based interventions aimed at preventing obesity in 4–6‐year‐olds. Searching was conducted from April 1995 to April 2010 using MEDLINE, EMBASE, CINAHL, PsycINFO and The Cochrane Library. Epidemiological studies relevant to the research question with controlled assignment of participants were included in the review, if they had follow‐up periods of 6 months or longer. Outcomes included markers of weight gain; markers of body composition; physical activity behaviour changes and dietary behaviour changes. Twelve studies were included in the review. The most commonly used model was social cognitive theory (SC...

Critical narrative review to identify educational strategies promoting physical activity in preschool

Obesity Reviews — Tue, 07 Feb 2012 10:44:22 +0100

SummaryThe aim of this narrative review is critically to evaluate educational strategies promoting physical activity that are used in the preschool setting in the context of obesity prevention programmes. Literature search was conducted between April and August 2010 in English and German databases (PubMED, PsychINFO, PSYNDEX, ERIC, FIS Bildung). Outcomes considered were time and intensity of physical activity, motor skills or measures of body composition. A total of 19 studies were included. Ten studies added physical activity lessons into their curriculum, one study provided more time for free play, eight studies focused on the social and play environment. Studies reporting positive outcomes implemented physical activity sessions that lasted at least 30 min d−1. Several studies show...

Energy balance‐related behaviours associated with overweight and obesity in preschool children: a systematic review of prospective studies

Obesity Reviews — Tue, 07 Feb 2012 10:44:17 +0100

SummaryThe current review aimed to systematically identify dietary, physical activity and sedentary behaviours in preschool children (4–6 years of age) that are prospectively related to overweight or obesity later in childhood. Prospective studies published between January 1990 and June 2010 were selected from searches in PubMed, EMBASE, PsycINFO, CINAHL and Cochrane Library. Studies examining the prospective association between at least one relevant behaviour measured during preschool period (children aged 4–6 years at baseline) in relation to at least one anthropometric measurement at follow‐up (age <18 years) were included. Harvest plots were used to summarize the results and draw conclusions from the evidence.Of the 8,718 retrieved papers, 23 papers reporting on 15 different s...

A systematic review on use of Chinese medicine and acupuncture for treatment of obesity

Obesity Reviews — Tue, 07 Feb 2012 10:43:24 +0100

SummaryObesity is a major health hazard and despite lifestyle modification, many patients frequently regain any lost body weight. The use of western anti‐obesity drugs has been limited by side effects including mood changes, suicidal thoughts, and gastrointestinal or cardiovascular complications. The effectiveness and safety of traditional Chinese medicine including Chinese herbal medicine (CHM) and acupuncture provide an alternative established therapy for this medical challenge. In this systematic review, we used standard methodologies to search, review, analyse and synthesize published data on the efficacy, safety and relapse of weight regain associated with use of CHM and acupuncture. We also examined the rationale, mechanisms and potential utility of these therapies. A total of 12 e...

MedWorm Sponsor Message: Find the best January Sales in the UK.

Laparoscopic versus Open Colectomy for Colon Cancer in an Older Population: A Cohort Study

World Journal of Surgical Oncology — Tue, 07 Feb 2012 05:00:00 +0100

Conclusions: In this older population, laparoscopic colectomy practice patterns were associated with factors which likely correlate with tertiary referral centers. Although short-term and long-term survival are comparable, laparoscopic colectomy offers shorter hospitalizations and less intensive care. (Source: World Journal of Surgical Oncology)

Comparative Effectiveness of Oxaliplatin vs Non-Oxaliplatin-containing Adjuvant Chemotherapy for Stage III Colon Cancer

JNCI — Tue, 07 Feb 2012 05:00:00 +0100

Conclusion The addition of oxaliplatin to 5-FU appears to be associated with better survival among patients receiving adjuvant colon cancer treatment in the community. (Source: JNCI)

Mild cognitive impairment is associated with disability and neuropsychiatric symptoms

EurekAlert! - Social and Behavioral Science — Tue, 07 Feb 2012 05:00:00 +0100

(Public Library of Science) In low- and middle-income countries, mild cognitive impairment -- an intermediate state between normal signs of cognitive aging, such as becoming increasingly forgetful, and dementia, which may or may not progress -- is consistently associated with higher disability and with neuropsychiatric symptoms but not with most socio-demographic factors, according to a large study published in this week's PLoS Medicine. (Source: EurekAlert! - Social and Behavioral Science)

More focus on men needed in HIV prevention

EurekAlert! - Social and Behavioral Science — Tue, 07 Feb 2012 05:00:00 +0100

(Public Library of Science) Edward Mills of the University of Ottawa, Canada and colleagues argue in this week's PLoS Medicine that the HIV/AIDS response in Africa needs a more balanced approach to gender, so that both men and women are involved in HIV treatment and prevention. (Source: EurekAlert! - Social and Behavioral Science)

Concordance between psychotropic prescribing for Veterans with PTSD and clinical practice guidelines

NeLM - Mental Health — Tue, 07 Feb 2012 05:00:00 +0100

This study aimed to determine which characteristics of veterans with diagnosed PTSD were associated with receiving prescriptions for benzodiazepines and mood stabilisers and second-generation antipsychotics. Methods: The survey responses of 482 veterans with PTSD were combined with prescription information from the US Veterans Affairs national pharmacy databases. The researchers assessed the use of eight classes of psychotropics prescribed for patients with PTSD in the year after a new PTSD diagnosis. Multivariate logistic regressions identified demographic ... (Source: NeLM - Mental Health)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Use of clopidogrel and calcium channel blockers and risk of major adverse cardiovascular events

European Journal of Clinical Investigation — Tue, 07 Feb 2012 02:06:17 +0100

Conclusions Concomitant use of CCBs as a class did not modify the protective effect of clopidogrel and was not associated with increased cardiovascular risk among patients using clopidogrel after coronary stent implantation. (Source: European Journal of Clinical Investigation)

EDUCATION: Spotlight! on NLM Resources -Feb. 8, 2012 1:00 Mountain Time, 2:00 Central Time -Mobile Resources

Midcontinental Region News — Mon, 06 Feb 2012 21:37:22 +0100

Ipads and tablets are the rage! What can you do with them? And other mobile resources? John Bramble will have some answers as he will be presenting the Spotlight! session on Feb 8 (not our usual end of month time but we didn’t want to conflict with the E-Science events at the University of Utah!) Taking the one-hour class and completing the exercises and class evaluation makes you eligible to receive 1 Medical Library Association Continuing Education credit. This online training is FREE. Register online at http://tinyurl.com/mcrclasses (registration is not required but is appreciated). URL: https://webmeeting.nih.gov/mcr/ Equipment: connection to the Internet and a phone, Login: as a guest with your first and last name. Instructions to connect to the audio will show up onc...

Access More Than 32,000 Harmonized Tariff Codes Now in CHEMLIST on STN

CAS - Chemical Abstracts Service — Mon, 06 Feb 2012 17:40:00 +0100

You can now search the new Harmonized Tariff Code (HTC) field in the CHEMLIST database on STN. Other CHEMLIST enhancements include EU Customs Codes display in the HTC field and chemical names in more languages. (Source: CAS - Chemical Abstracts Service)

February NIH News in Health Now Available

Midcontinental Region News — Mon, 06 Feb 2012 17:35:07 +0100

The February 2012 issue of NIH News in Health is now available online. This month learn steps you can take to reduce heart risks and find out the symptoms of irritable bowel syndrome. Visit the NIH News in Health Facebook page to suggest topics or start a discussion about the newsletter. da (Source: Midcontinental Region News)

Am J Geriatr Psychiatry; +17 new citations

Am J Geriatr Psychia... — Mon, 06 Feb 2012 15:06:02 +0100

17 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Geriatr Psychiatry These pubmed results were generated on 2012/02/06PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Geriatr Psychia...)

MedWorm Sponsor Message: Find the best January Sales in the UK.

Am J Trop Med Hyg; +67 new citations

Am J Trop Med Hyg — Mon, 06 Feb 2012 14:54:02 +0100

67 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Trop Med Hyg These pubmed results were generated on 2012/02/06PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Trop Med Hyg)

Community of Science Transformed to ‘Pivot’

What's New on JEFFLINE — Mon, 06 Feb 2012 14:41:19 +0100

The old familiar Community of Science (COS) Funding Opportunities database has gone away. In its place, you’ll find the new COS Pivot database. Pivot is a major step forward for COS, combining a much easier searching interface with a new profile option for grant seekers. Rest assured – your funding search still covers all the tens of thousands of opportunities the old database offered. You can still search by title, sponsor, abstract, deadline, amount of award, and more. You’ll be able to get regular alerts, share information about opportunities with colleagues, and track individual opportunities. But click on the Profiles tab, and you’ll find that you probably already have a record in the database, so that potential collaborators can find you and vice versa. Register...

New ‘JeffHELP’ Team to Offer Support After a Loss

What's New on JEFFLINE — Mon, 06 Feb 2012 13:38:57 +0100

As students, faculty members and employees of Jefferson, all of us share a common goal — to deliver high-quality care to patients in need. Sometimes, though, we, too, need access to resources to help care for ourselves during defining moments that can forever change our lives. The death of a loved one or important person in our lives, through suicide or other traumatic event can be one of the most difficult and stressful experiences we ever face. With that loss comes a strong feeling of helplessness, loneliness and lack of hope. Having access to the right tools to cope with our grief and loss is essential to the healing process. Recognizing this, Jefferson has recently formed JeffHELP, a campus-wide suicide prevention team. The group is currently in the process of determining ways in...

Osmotic Stress Induces the Expression of VvMAP Kinase Gene in Grapevine (Vitis vinifera L.)

Advances in Urology — Mon, 06 Feb 2012 12:46:42 +0100

Abiotic stress adversely affects the growth of grapevine plants. In order to study the early expression changes of genes particularly involved in signal transduction upon salt and drought stresses in grapevines, ESTs derived from a suppressive subtractive hybridization approach (SSH) were selected for expression studies. We were particularly interested in the expression behaviour of the MAP kinase cDNA clone identified by differential screening of the salt-stressed SSH libraries. Interestingly, VvMAP kinase transcript showed a differential expression towards salt and drought treatment in the salt tolerant cultivar Razegui. The upregulation of this transcript was confirmed by RNA blot analysis. Our results revealed that the VvMAP kinase gene could be classified as an osmotic stress responsi...

Monitoring adverse drug reactions across a nationwide health care system using information technology.

American Journal of Health-System Pharmacy : AJHP — Mon, 06 Feb 2012 12:06:42 +0100

Conclusion In recent years, the refinement of two databases for ADR reporting has increased VA's capability to systematically monitor, track, and report ADRs across its national network of health care facilities. Linking the two databases has further strengthened those capabilities, enhancing medication safety practices and aiding in pharmacovigilance. PMID: 22302257 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

DNA2.0 Introduces Protein Variant Libraries

PRWeb: Medical Pharmaceuticals — Mon, 06 Feb 2012 06:00:14 +0100

Powerful Research Tools for Protein and Antibody Engineering Through Directed Evolution(PRWeb February 02, 2012)Read the full story at http://www.prweb.com/releases/2012/2/prweb9151697.htm (Source: PRWeb: Medical Pharmaceuticals)

Cost-effectiveness of transcatheter aortic valve replacement in patients ineligible for conventional aortic valve replacement

Heart — Mon, 06 Feb 2012 05:00:00 +0100

Conclusions TAVI is highly likely to be a cost-effective treatment for patients with severe aortic stenosis who are currently ineligible for SAVR. (Source: Heart)

Small interfering RNA library screen identified polo-like kinase-1 (PLK1) as a potential therapeutic target for breast cancer that uniquely eliminates tumour-initiating cells

Breast Cancer Research — Mon, 06 Feb 2012 05:00:00 +0100

Conclusion: Inhibiting PLK1 with siRNA or BI 2536 blocked growth of TNBCs including the CD44high/CD24-/low TIC subpopulation and mammosphere formation. Thus, PLK1 could be a potential therapeutic target for the treatment of TNBC as well as other subtypes of breast cancer. (Source: Breast Cancer Research)

Goitrogens

About.com Eating Disorders — Mon, 06 Feb 2012 05:00:00 +0100

and Thyroid Drugs, Mary Shomon's Thyroid Drug Database, featuring Thyroid Drugs & Manufacturers, and Information on Drugs Including Synthroid, Levothyroxine, Armour, Cytomel, T3 and Others (Source: About.com Eating Disorders)

Automated 3D MRI volumetry reveals regional atrophy differences in Rasmussen encephalitis

Epilepsia — Mon, 06 Feb 2012 05:00:00 +0100

In this study we present a fully automated volumetric approach applied to serial MRI scans of 12 patients with Rasmussen encephalitis.Methods: We retrospectively analyzed 12 patients with Rasmussen encephalitis with a disease onset between 2001 and 2008. All patients underwent a total of 66 serial MRI scans including a three‐dimensional T1 data set. The volumetric analysis was based on standard procedures of the freely available software FMRIB Software Library (FSL) and required about 45 min per scan. Furthermore, planimetric analyses were performed on 51 scans as described previously.Key Findings: The relative and absolute volume loss of the affected hemisphere was significantly higher compared to the unaffected hemisphere. Referring to regional atrophy differences our results s...

MedWorm Sponsor Message: Find the best January Sales in the UK.

Mechanism and specificity of the human paracaspase MALT1

BJ Signal — Mon, 06 Feb 2012 05:00:00 +0100

The paracaspase domain of MALT1 (mucosa-associated lymphoid tissue lymphoma translocation protein 1) is a component of a gene translocation fused to the N-terminal domains of the cellular inhibitor of apoptosis protein 2. The paracaspase itself, commonly known as MALT1, participates in the NF-κB pathway, likely by driving survival signals downstream of the B-cell antigen receptor through MALT1 proteolytic activity. We have developed methods for the expression and purification of recombinant full-length MALT1 and its constituent catalytic domain alone. Both are activated by dimerization without cleavage, with a similar dimerization barrier to the distantly related cousins, the apical caspases. By using positional scanning peptidyl substrate libraries we demonstrate that the activity ...

New database aims to improve emergency general surgery care and outcomes

EurekAlert! - Medicine and Health — Mon, 06 Feb 2012 05:00:00 +0100

(Weber Shandwick Worldwide) Researchers at Wake Forest Baptist Medical Center in Winston-Salem, N.C., have successfully created and implemented an emergency general surgery registry that will advance the science of acute surgical care by allowing surgeons to track and improve surgical patient outcomes, create performance metrics, conduct valid research and ensure quality care for all emergency general surgery patients. (Source: EurekAlert! - Medicine and Health)

Medicago truncatula transporter database: a comprehensive database resource for M. truncatula transporters

BMC Genomics - Latest articles — Mon, 06 Feb 2012 05:00:00 +0100

Conclusions: In summary, the MTDB enables the exploration and comparative analysis of putative transporters in M. truncatula. A user-friendly web interface and regular updates make MTDB valuable to researchers in related fields. The MTDB is freely available now to all users at http://bioinformatics.cau.edu.cn/MtTransporter/. (Source: BMC Genomics - Latest articles)

Heavy smoking during pregnancy as a marker for other risk factors of adverse birth outcomes: a population-based study in British Columbia, Canada

BMC Public Health - Latest articles — Mon, 06 Feb 2012 05:00:00 +0100

Conclusion: Our data suggests that self reports of heavy smoking early in pregnancy could be used as a marker for lifestyle risk factors that in combination with smoking influence birth outcomes. This information may be used for planning targeted intervention programs for not only smoking cessation, but potentially other support services such as nutrition and healthy pregnancy education. (Source: BMC Public Health - Latest articles)

"Atherosclerosis"; +115 new citations

Atherosclerosis — Mon, 06 Feb 2012 03:12:01 +0100

115 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Atherosclerosis" These pubmed results were generated on 2012/02/05PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Atherosclerosis)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Meta-analysis of the clinical effect of ligustrazine on diabetic nephropathy.

The American Journal of Chinese Medicine — Mon, 06 Feb 2012 03:06:02 +0100

Authors: Wang B, Ni Q, Wang X, Lin L Abstract Ligustrazine, a bioactive component contained in Chuanxiong (Ligusticum chuanxiong Hort), is widely applied in the treatment of vascular diseases in China, e.g. myocardial and cerebral infarction. The aim of this study was to perform a meta-analysis of randomized controlled trials (RCTs) to evaluate the clinical effect of Ligustrazine on diabetic nephropathy (DN). PUBMED, EMBASE, the Cochrane Central Register of Controlled Trials (CENTRAL), Chinese Biological Medicine Database (CBM), China National Knowledge Infrastructure (CNKI) Database, etc. were searched by computer and manual methods to identify RCTs that were used to evaluate the clinical effect of Ligustrazine on DN patients. Twenty five studies comprising 25 RCTs were involved i...

Mitral valve myxoma: Clinical features, current diagnostic approaches, and surgical management.

Cardiology Journal — Mon, 06 Feb 2012 00:36:02 +0100

Conclusions: Two- and three-dimensional echocardiography and magnetic resonance imaging are the major diagnostic tools for the diagnosis of a cardiac myxoma. After diagnosis, surgery should be performed urgently, in order to prevent complications such as embolic events or obstruction of the mitral orifice. Due to the fact that myxomas can recur, regular, postoperative cardiological control is mandatory. (Cardiol J 2012; 19, 1: 105-109). PMID: 22298179 [PubMed - in process] (Source: Cardiology Journal)

What Are the Major Diseases Involving Copper Metabolism?

PediatricEducation.org — Mon, 06 Feb 2012 00:08:49 +0100

Discussion Nutritional problems can occur in all parts of the world and in all socioeconomic strata. Caloric and/or protein inadequacy unfortunately plagues too many people because of inadequate supplies or availability. Supplemental food programs around the world attempt to provide appropriate nutrition, but can be stymied because of war, political instability, economic instability and many other social factors. The most common specific nutrient deficiencies are iron and Vitamin D deficiencies. Minerals important for essential nutrition include copper, iodine, selenium and zinc. A typical mixed diet usually provides enough minerals. In the United States, mineral deficiencies are usually uncommon unless there is an underlying disease process or abnormal food restrictions or diet. Vegan an...

The European internet-based patient and research database for primary immunodeficiencies: update 2011.

Clinical and Developmental Immunology — Sun, 05 Feb 2012 16:25:37 +0100

Authors: Gathmann B, Binder N, Ehl S, Kindle G, Abstract In order to build a common data pool and estimate the disease burden of primary immunodeficiencies (PID) in Europe, the European Society for Immunodeficiencies (ESID) has developed an internet-based database for clinical and research data on patients with PID. This database is a platform for epidemiological analyses as well as the development of new diagnostic and therapeutic strategies and the identification of novel disease-associated genes. Since its start in 2004, 13 708 patients from 41 countries have been documented in the ESID database. Common variable immunodeficiency (CVID) represents the most common entity with 2880 patients or 21% of all entries, followed by selective immunoglobulin A (sIgA) deficiency (1424 pat...

Vortex Formation in the Cardiovascular System(Kheradvar et al.)

Springer Medicine titles — Sun, 05 Feb 2012 15:44:11 +0100

(Source: Springer Medicine titles)

MedWorm Sponsor Message: Find the best January Sales in the UK.

Battling Lung Cancer With Combination Drug Therapy

Health News from Medical News Today — Sun, 05 Feb 2012 08:00:00 +0100

Combination drug therapy may be needed to combat non-small cell lung cancer (NSCLC), according to a study by the Translational Genomics Research Institute (TGen) and Van Andel Research Institute (VARI). The study, "STAT3 is Activated by JAK2 Independent of Key Oncogenic Driver Mutation in Non-Small Cell Lung Carcinoma," was published online by the Public Library of Science (PLoS) ONE. The study found that in NSCLC - the most common form of lung cancer - that the STAT3 gene is activated in some NSCLC cell lines by the JAK2 protein... (Source: Health News from Medical News Today)

Molecular Biology of Diabetes, Part II

Springer Medicine titles — Sun, 05 Feb 2012 06:01:08 +0100

Insulin Action, Effects on Gene Expression and Regulation, and Glucose TransportThese comprehensive yet concise collections of articles by world experts survey the latest findings on the molecular biology of diabetes and insulin action and synthesize a coherent understanding of the subject. Topics include the etiology of type I and type II diabetes, molecular and cellular aspects of insulin action, and the mechanism of the insulin-stimulated glucose uptake. (Source: Springer Medicine titles)

Use and Costs of Prescription Medications and Alternative Treatments in Patients with Osteoarthritis and Chronic Low Back Pain in Community‐Based Settings

Pain Practice — Sun, 05 Feb 2012 05:00:00 +0100

Conclusions: Patients with OA and CLBP used a variety of pain‐related and adjunctive medications. Although, alternative treatments are widely recommended, we found limited use of several of these in clinical practice, potentially due to the source of our data (commercial claims). Further research is needed to ascertain the extent to which such therapies contribute to the total costs of OA and CLBP management. (Source: Pain Practice)

Satisfaction, Motivation, and Future of Community Preceptors (Robyn Latessa MD)

Family Medicine Digital Resources Library (FMDRL) Recently Uploaded — Sun, 05 Feb 2012 05:00:00 +0100

Findings from repeat of longitudinal study conducted in one state of all AHEC community-based primary care preceptors of health science students, comparing current findings with those from six years earlier, and reporting on satisfaction, motivation, incentives/rewards valued, reasons for teaching, likelihood to continue, and discussion of implications. (Source: Family Medicine Digital Resources Library (FMDRL) Recently Uploaded)

Rupert Sheldrake: the 'heretic' at odds with scientific dogma

Guardian Unlimited Science — Sun, 05 Feb 2012 00:04:00 +0100

Rupert Sheldrake has researched telepathy in dogs, crystals and Chinese medicine in his quest to explore phenomena that science finds hard to explainIt is not often, in liberal north London, that you come face to face with a heretic, but Rupert Sheldrake has worn that mantle, pretty cheerfully, for 30 years now. Sitting in his book-lined study, overlooking Hampstead Heath, he appears a highly unlikely candidate for apostasy; he seems more like the Cambridge biochemistry don he once was, one of the brightest Darwinians of his generation, winner of the university botany prize, researcher at the Royal Society, Harvard scholar and fellow of Clare College.All that, though, was before he was cast out into the wilderness. Sheldrake's untouchable status was conferred one morning in 1981 when, a co...

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Nuclear Medicine Imaging: An Encyclopedic Dictionary(Thie)

Springer Medicine titles — Sun, 05 Feb 2012 00:02:05 +0100

(Source: Springer Medicine titles)

Genes Linked To Alzheimer's Are The Same For Early- And Late-Onset

Health News from Medical News Today — Sat, 04 Feb 2012 08:00:00 +0100

The same gene mutations linked to inherited, early-onset Alzheimer's disease have been found in people with the more common late-onset form of the illness. The discovery by researchers at Washington University School of Medicine in St. Louis may lead doctors and researchers to change the way Alzheimer's disease is classified. They reported their findings in the online journal PLoS One (Public Library of Science)... (Source: Health News from Medical News Today)

Medical Spanish Close to Home--An Inner-City Spanish Immersion Elective for Medical Students (Keith Nokes MD, MPH)

Family Medicine Digital Resources Library (FMDRL) Recently Uploaded — Sat, 04 Feb 2012 05:00:00 +0100

(Source: Family Medicine Digital Resources Library (FMDRL) Recently Uploaded)

Medical Student Teaching in Teaching Health Centers (Keith Nokes MD, MPH)

Family Medicine Digital Resources Library (FMDRL) Recently Uploaded — Sat, 04 Feb 2012 05:00:00 +0100

(Source: Family Medicine Digital Resources Library (FMDRL) Recently Uploaded)

C-STAHR: Reducing Discrimination in Healthcare (Brooke Thurman Medical student)

Family Medicine Digital Resources Library (FMDRL) Recently Uploaded — Sat, 04 Feb 2012 05:00:00 +0100

We are C-STAHR: Community-Students Against Healthcare Racism, a group of medical students from the University of Colorado working with 2040 Partners for health and community leaders to improve health care experiences in Denver and Aurora. We are Latino, black, white, men, women, old and young. What brings us together is the desire to combat racism and improve medical care. Our vision: For students and the community to work together to better understand perceived discrimination and design a feasible intervention to better equip future physicians and community members to reduce its effects (Source: Family Medicine Digital Resources Library (FMDRL) Recently Uploaded)

MedWorm Sponsor Message: Find the best January Sales in the UK.

Using Formative Assessment in Active Learning Environments: Transitioning from Preclinical to Clinical Training (Linda Chang PharmD)

Family Medicine Digital Resources Library (FMDRL) Recently Uploaded — Sat, 04 Feb 2012 05:00:00 +0100

Many medical students struggle as they enter the clinical setting because they have difficulty in integrating and applying what they have learned in the preclinical classroom. In order to address this challenge, active learning activities were added to the Essentials of Patient Care course for second year medical students. This PowerPoint was presented at the 38th Annual STFM Conference on Medical Student Education and presents 1) the structure of the course that encompasses cultural competency, health policy, preventive medicine, epidemiology/evidence-based medicine, and medical ethics; 2) examples of the active learning activities; 3) the formative assessment of students' performance in these activities qualitatively and quantitatively; and 4) the use of these assessment data to improve ...

Summary of Discussion Session S5 Teaching Practice Standards MSE12 conference (Beat Steiner MD, MPH)

Family Medicine Digital Resources Library (FMDRL) Recently Uploaded — Sat, 04 Feb 2012 05:00:00 +0100

Summary of discussion from Session S5 on Feb 3 2012 by about 30 medical student educators discussion standards for community teaching practices (Source: Family Medicine Digital Resources Library (FMDRL) Recently Uploaded)

From Motivational Interviewing to Systems Based Care (Carolyn Wellbery MD, PhD)

Family Medicine Digital Resources Library (FMDRL) Recently Uploaded — Sat, 04 Feb 2012 05:00:00 +0100

From Motivational Interviewing to Systems based care: A Third-Year Clerkship Chronic Care Model Curriculum and OSCE (Source: Family Medicine Digital Resources Library (FMDRL) Recently Uploaded)

MS/MS library facilitated MRM quantification of native peptides prepared by denaturing ultrafiltration

BioMed Central — Sat, 04 Feb 2012 05:00:00 +0100

Naturally occurring native peptides provide important information about physiological states of an organism and its changes in disease conditions but protocols and methods for assessing their abundance are not well-developed. In this paper, we describe a simple procedure for the quantification of non-tryptic peptides in body fluids. The workflow includes an enrichment step followed by two-dimensional fractionation of native peptides and MS/MS data management facilitating the design and validation of LC- MRM MS assays. The added value of the workflow is demonstrated in the development of a triplex LC-MRM MS assay used for quantification of peptides potentially associated with the progression of liver disease to hepatocellular carcinoma. (Source: BioMed Central)

STIR: software for tomographic image reconstruction release 2.

Physics in Medicine and Biology — Sat, 04 Feb 2012 04:38:20 +0100

We present a new version of STIR (Software for Tomographic Image Reconstruction), an open source object-oriented library implemented in C++ for 3D positron emission tomography reconstruction. This library has been designed such that it can be used for many algorithms and scanner geometries, while being portable to various computing platforms. This second release enhances its flexibility and modular design and includes additional features such as Compton scatter simulation, an additional iterative reconstruction algorithm and parametric image reconstruction (both indirect and direct). We discuss the new features in this release and present example results. STIR can be downloaded from http://stir.sourceforge.net. PMID: 22290410 [PubMed - in process] (Source: Physics in Medicine and Biol...

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Myeloproliferative Neoplasms

Springer Medicine titles — Sat, 04 Feb 2012 00:09:38 +0100

Critical Concepts and Managementseries:Hematologic MalignanciesMyeloproliferative neoplasms (MPNs) are clonal stem cell diseases that, under the World Health Organization classification, are subcategorized into eight clinicopathologic entities. The current book focuses on three of these categories: polycythemia vera, essential thrombocythemia, and primary myelofibrosis. A number of important questions regarding the diagnosis, prognosis, and treatment of ... (Source: Springer Medicine titles)

Interested in an iPad Programming Class?

NN/LM Middle Atlantic Region Blog — Fri, 03 Feb 2012 21:32:57 +0100

Carnegie Mellon University, known as one of the nation’s leading computer science schools, offered a course on iPad programming. On the first day, the 30-person class saw 90 students show up and had a 75-student waiting list. The school is putting the course lectures online for free on iTunesU. The course is intended to help [...] (Source: NN/LM Middle Atlantic Region Blog)

The NIH Public Access Policy (February 2012)

NN/LM Middle Atlantic Region Blog — Fri, 03 Feb 2012 21:32:10 +0100

The NIH released a February 2012 document summarizing its public access policy… “WHAT IS AT STAKE UNDER THE PUBLIC ACCESS POLICY: Opening up to the public 90,000 new scientific articles each year reporting research that U.S. taxpayers have funded through NIH’s annual 32 billion dollar investment in biomedical research… HOW IT WORKS: The NIH policy [...] (Source: NN/LM Middle Atlantic Region Blog)

New Rural Health Information Technology (HIT) Toolkit

NN/LM Middle Atlantic Region Blog — Fri, 03 Feb 2012 21:30:14 +0100

The Rural Assistance Center and the National Rural Health Resources Center recently announced the release of an online health IT toolkit aimed at helping rural health care providers plan and implement health IT projects. HHS’ Office of Rural Health Policy provided funding to support the development of the online toolkit (AHA News, 1/27). Toolkit Details [...] (Source: NN/LM Middle Atlantic Region Blog)

NeHC University: HIT Orientation

NN/LM Middle Atlantic Region Blog — Fri, 03 Feb 2012 21:29:41 +0100

National eHealth Collaborative (NeHC) University is back in session. The new Spring 2012 semester kicked off February 1st. The NeHC University will welcome Gwenn Darlinger, Project Manager at Blue Cross and Blue Shield Association, to lead another installment of HIT Orientation, a comprehensive introduction to health IT in under two hours! The HIT Orientation program [...] (Source: NN/LM Middle Atlantic Region Blog)

MedWorm Sponsor Message: Find the best January Sales in the UK.

2011-2016 NNLM Membership Certificates Forthcoming

NN/LM Middle Atlantic Region Blog — Fri, 03 Feb 2012 21:28:42 +0100

MAR is in the process of reviewing and updating the contents of our membership files. So we want you all to know that it may be several weeks before we’re able to send new certificates out to all our members. We thank you for your patience. If you have any questions, please contact our Network [...] (Source: NN/LM Middle Atlantic Region Blog)

PubMed for Trainers Coming to Our Region

NN/LM Middle Atlantic Region Blog — Fri, 03 Feb 2012 21:26:52 +0100

The National Library of Medicine Training Center is bringing their PubMed for Trainers course to Syracuse, NY, April 16-30, 2012. The course requires attendance at all sessions, both online and in-person: Online session: April 16, 2012 (10:00 am – 12:00 pm ET) Online session: April 18, 2012 (10:00 am – 12:00 pm ET) [...] (Source: NN/LM Middle Atlantic Region Blog)

Discussion following the 2012 Priscilla M. Mayden Lecture: eScience and the Evolution of Library Services

Midcontinental Region News — Fri, 03 Feb 2012 21:25:05 +0100

Join us on Wednesday, February 29 at 10 MT/11 CT, for a follow-up discussion of Bart Ragon’s keynote address, eScience and the Evolution of Library Services, and the expert panel discussion. The 2012 Priscilla Mayden lecture on February 22 is sponsored by the Spencer S. Eccles Health Sciences Library, University of Utah. The Mayden lecture will be broadcast February 22, beginning at 1:00-2:00 pm MT/2:00-3:00 pm CT, followed by a broadcast of the panel discussion from 2:30 – 4 MT/3:30 – 5 CT. On February 29, 10 MT/11 CT, all who attended either online or in person will have an opportunity to share thoughts and reactions to Bart’s and the panelists’ messages using Adobe Connect. We’ll meet in https://webmeeting.nih.gov/mcr. Mark your calendar now – listen to the Mayden lecture...

Semimonthly new journal report by provider (02/03/2012)

Library-LinkOut Announcements — Fri, 03 Feb 2012 20:50:00 +0100

LinkOut journals added since 01/16/2012, arrangedby provider. (Source: Library-LinkOut Announcements)

Are Nuisance Jellyfish Really Taking Over the World's Oceans?

BioScience Press Releases — Fri, 03 Feb 2012 19:26:33 +0100

In recent years, media reports of jellyfish blooms and some scientific publications have fueled the idea that jellyfish and other gelatinous floating creatures are becoming more common and may dominate the seas in coming decades. The growing impacts of humans on the oceans, including overfishing and climate change, have been suggested as possible causes of this apparently alarming trend. A careful evaluation of the evidence by Robert H. Condon of Dauphin Island Sea Lab and his 16 coauthors, however, finds the idea that jellyfish, comb jellies, salps and similar organisms are surging globally to be lacking support. Rather, Condon and his colleagues suggest, the perception of an increase is the result of more scientific attention being paid to phenomena such as jellyfish blooms and media fa...

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

High-precision map of Milky Way's magnetic fields charted

ScienceDaily Headlines — Fri, 03 Feb 2012 19:15:15 +0100

Scientists have pooled their radio observations into a database, producing the highest precision map to date of the magnetic field within our own Milky Way galaxy. (Source: ScienceDaily Headlines)

MDCT of abdominal wall lumbar hernias: anatomical review, pathologic findings and differential diagnosis

Surgical and Radiologic Anatomy — Fri, 03 Feb 2012 17:12:01 +0100

Conclusions Currently available MDCT provides an excellent opportunity for reviewing the normal anatomy of the wall lumbar region and may be considered a useful modality for evaluating lumbar hernias. Content Type Journal ArticleCategory Anatomic Bases of Medical, Radiological and Surgical TechniquesPages 1-9DOI 10.1007/s00276-012-0937-8Authors Joaquín Martín, Department of Radiology, Hospital Reina Sofía, Ctra Tarazona km 3, 31500 Tudela, Navarra, SpainJosé María Mellado, Department of Radiology, Hospital Reina Sofía, Ctra Tarazona km 3, 31500 Tudela, Navarra, SpainSusana Solanas, Department of Radiology, Hospital Reina Sofía, Ctra Tarazona km 3, 31500 Tudela, Navarra, SpainNerea Yanguas, Department of Radiology, Hospital Reina Sofía, Ctra Tarazona km 3, 315...

Men with Strokes Call for Help Quicker Than Women, Mayo Clinic Study Says

News from Mayo Clinic — Fri, 03 Feb 2012 16:45:46 +0100

A Mayo Clinic study, presented at the American Stroke Conference in New Orleans in early February, says that men experiencing a stroke call for emergency help quicker than women, especially if they are married. (Source: News from Mayo Clinic)

Equality for all: delivering safe care - seven days a week

The Kings Fund - Health Management Specialist Collection — Fri, 03 Feb 2012 14:44:30 +0100

This publication brings together case studies which demonstrate where extended working days or weeks have been successfully implemented to ensure that patients are able to readily access both acute, elective and reablement services across primary and secondary care. Report NHS Improvement - publications (Source: The Kings Fund - Health Management Specialist Collection)

Resources for clinical commissioning groups (CCGs)

The Kings Fund - Health Management Specialist Collection — Fri, 03 Feb 2012 14:33:05 +0100

These are resources which may be useful for emerging CCGs. They include guidance and process documents, toolkits and other information around authorisation, governance, establishment and commissioning support. Developing CCGs: towards authorisation Towards establishment: creating responsible and accountable CCGs Developing commissioning support: towards service excellence NHS Commissioning Board - publications (Source: The Kings Fund - Health Management Specialist Collection)

MedWorm Sponsor Message: Find the best January Sales in the UK.

Paying for quality: an analysis of the impact of the 2012/11 Commissioning for Quality and Innovation Scheme (CQUINs) in London

The Kings Fund - Health Management Specialist Collection — Fri, 03 Feb 2012 14:13:43 +0100

This report provides a detailed analysis of the impact of CQUINs in London, examining which issues were incentivised in 2010/11, how providers performed against their targets, as well the financial impact of this performance. It found that in 2010/11, London hospitals missed out on nearly £22 million of revenue as a result of failing to meet CQUIN goals – some 23% of the total available. Report MHP Health Mandate - news (Source: The Kings Fund - Health Management Specialist Collection)

Books received this week | @GrrlScientist

Guardian Unlimited Science — Fri, 03 Feb 2012 14:00:01 +0100

This is my "quick skim impression" of three books -- a field guide to birds of New Zealand, and two Lab Lit novels -- and an audio CD of birdsongs of the northern NeotropicsOne of many shelves in GrrlScientist's library [ (Source: Guardian Unlimited Science)

"Angew Chem Int Ed Engl"[ta]; +126 new citations

Angewandte Chemie — Fri, 03 Feb 2012 12:36:02 +0100

126 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Angew Chem Int Ed Engl"[ta] These pubmed results were generated on 2012/02/03PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Angewandte Chemie)

Vitamin D - advice on supplements for at risk groups

The Kings Fund - Health Management Specialist Collection — Fri, 03 Feb 2012 11:56:25 +0100

This letter from the Chief Medical Officers for the United Kingdom published today, raises awareness of the risk of vitamin D deficiency amongst certain groups in the population. It contains a list of recommendations issued by all the UK health departments for people at risk on whether they may need to take vitamin D supplements. Letter Department of Health - letters (Source: The Kings Fund - Health Management Specialist Collection)

Genetic diversity of Metrodorea nigra (Rutaceae) from a small forest remnant in Brazil assessed with microsatellite markers.

Genetics and Molecular Research — Fri, 03 Feb 2012 11:24:05 +0100

Genetic diversity of Metrodorea nigra (Rutaceae) from a small forest remnant in Brazil assessed with microsatellite markers. Genet Mol Res. 2012;11(1):10-6 Authors: Guidugli MC, Ferreira-Ramos R, de Sousa AC, Cidade FW, Marconi TG, Mestriner MA, Groppo M, Alzate-Marin AL Abstract Metrodorea nigra (Rutaceae) is an endemic Brazilian tree of great ecological importance, frequently found in the submontane regions of ombrophilous dense and semideciduous forests. This tree is useful for reforesting degraded areas and the wood can be employed in construction. We developed 12 microsatellite markers from a genomic library enriched for GA/CA repeats, for this species. Polymorphisms were assessed in 40 trees of a highly fragmented population found in Cravinhos, State of São Paulo, in...

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Intraoperative, postoperative and reoperative problems with ileoanal pouches

British Journal of Surgery — Fri, 03 Feb 2012 11:07:28 +0100

Conclusion:A structured management plan will minimize the adverse consequences of the problems associated with pouches. Copyright © 2012 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. (Source: British Journal of Surgery)

Malaria deaths 'higher than expected'

NHS News Feed — Fri, 03 Feb 2012 09:42:00 +0100

Conclusion This study has looked at a lot of data and used systematic methods to examine trends in malaria mortality over the past 30 years. It shows that malaria in 2010 was the cause of death for 1.2 million individuals, including 714,000 deaths in children younger than five years and 524,000 in individuals aged five years or older. The results tend to show an increase in mortality from 1980 to peak levels in 2004, but since then a clear decline. The researchers say that the recent decrease in malaria mortality in Africa in particular is due to malaria control activities being increased, supported by international help. They say that support from international donors needs to increase further if malaria is to be eradicated. However, the primary aim of this study was to predict trends ove...

Aggressive Management of Peritoneal Carcinomatosis from Mucinous Appendiceal Neoplasms

Annals of Surgical Oncology — Fri, 03 Feb 2012 07:21:20 +0100

Conclusions Aggressive management of PC from mucinous appendiceal neoplasms, by experienced surgeons, to achieve complete cytoreduction provides long-term survival with low major morbidity. Content Type Journal ArticleCategory Regional Cancer TherapiesPages 1-8DOI 10.1245/s10434-012-2241-6Authors Frances Austin, Division of Surgical Oncology, University of Pittsburgh, Pittsburgh, PA, USAArun Mavanur, Division of Surgical Oncology, University of Pittsburgh, Pittsburgh, PA, USAMagesh Sathaiah, Division of Surgical Oncology, University of Pittsburgh, Pittsburgh, PA, USAJennifer Steel, Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USADiana Lenzner, Biostatistics Facility, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USALekshmi Ramali...

Importance of Histologic Subtype in the Staging of Appendiceal Tumors

Annals of Surgical Oncology — Fri, 03 Feb 2012 07:21:18 +0100

Conclusions Histologic subtype is an important predictor of disease-specific survival and overall survival in patients with appendiceal neoplasms. Addition of the histologic subtype to the TNM staging is simple and may improve prognostication. Content Type Journal ArticleCategory Regional Cancer TherapiesPages 1-7DOI 10.1245/s10434-012-2238-1Authors Kiran K. Turaga, Division of Surgical Oncology, Medical College of Wisconsin, Milwaukee, WI, USASam G. Pappas, Division of Surgical Oncology, Medical College of Wisconsin, Milwaukee, WI, USAT. Clark Gamblin, Division of Surgical Oncology, Medical College of Wisconsin, Milwaukee, WI, USA Journal Annals of Surgical OncologyOnline ISSN 1534-4681Print ISSN 1068-9265 (Source: Annals of Surgical Oncology)

Cytoreductive Surgery with Selective Versus Complete Parietal Peritonectomy Followed by Hyperthermic Intraperitoneal Chemotherapy in Patients with Diffuse Malignant Peritoneal Mesothelioma: A Controlled Study

Annals of Surgical Oncology — Fri, 03 Feb 2012 07:21:17 +0100

Conclusions CPP improved survival in patients with DMPM undergoing combined treatment. This information may contribute to standardize surgical options for DMPM and other peritoneal malignancies. Content Type Journal ArticleCategory Regional Cancer TherapiesPages 1-9DOI 10.1245/s10434-012-2237-2Authors Dario Baratti, Department of Surgery, Fondazione IRCCS Istituto Nazionale Tumori, Milan, ItalyShigeki Kusamura, Department of Surgery, Fondazione IRCCS Istituto Nazionale Tumori, Milan, ItalyAntonello Domenico Cabras, Department of Pathology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, ItalyMarcello Deraco, Department of Surgery, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy Journal Annals of Surgical OncologyOnline ISSN 1534-4681Print ISSN 1068...

MedWorm Sponsor Message: Find the best January Sales in the UK.

Neuromodulators for pain management in rheumatoid arthritis

Prescriber — Fri, 03 Feb 2012 06:47:12 +0100

(Source: Prescriber)

New international standards to aid data sharing

MEDEV News — Fri, 03 Feb 2012 06:38:29 +0100

Led by researchers at University of Oxford (UK) and the Harvard Stem Cell Institute (HSCI) at Harvard University, (USA), more than 50 collaborators at over 30 scientific organizations around the globe have agreed on a common standard for integrating biological data sets. This will make it possible to consistently describe the enormous and radically different databases that are compiled in the biosciences in fields ranging from genetics to stem cell science, to environmental studies.This collaborative effort provides a way for scientists in widely disparate life science fields to co-ordinate each other's findings by allowing behind-the-scenes combination of the mountains of data produced by modern, technology driven science. This will allow researchers to put data to work more effectively a...

Neurodevelopmental delay in small babies at term. A systematic review.

The Ultrasound Review of Obstetrics and Gynecology — Fri, 03 Feb 2012 05:00:00 +0100

Authors: Arcangeli T, Thilaganathan B, Hooper R, Khan KS, Bhide A Abstract Background: Being small for gestational age (SGA) or having fetal growth restriction (FGR) may be associated with poorer neurodevelopmental outcomes compared to being appropriate for gestational age (AGA). The aim of this paper was to evaluate the existence and magnitude of decrease in neurodevelopmental scores in SGA and FGR infants born at term from a systematic review of the existing literature. Methods: Studies of neurodevelopment in SGA/FGR babies were identified from a search of the internet scientific databases. Studies which included preterm births and those that did not define absolute indices of standardised cognitive outcome were excluded. SGA was defined as birthweight below the 10(th) centile fo...

Radio Frequency Ablation vs. Bipolar Umbilical Cord Coagulation in the Management of Complex Monochorionic Pregnancies.

The Ultrasound Review of Obstetrics and Gynecology — Fri, 03 Feb 2012 05:00:00 +0100

CONCLUSION: Despite the smaller caliber of the instrument, RFA is not associated with a decrease in the overall complication rate for selective termination procedures. The technique used for selective termination should still be determined by technical considerations but patients should be informed of the survival associated with each technique. Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd. PMID: 22302774 [PubMed - as supplied by publisher] (Source: The Ultrasound Review of Obstetrics and Gynecology)

Regulation of Myb by Cdk2 in Giardia [Microbiology]

Journal of Biological Chemistry — Fri, 03 Feb 2012 05:00:00 +0100

The protozoan Giardia lamblia parasitizes the human small intestine to cause diseases. It undergoes differentiation into infectious cysts by responding to intestinal stimulation. How the activated signal transduction pathways relate to encystation stimulation remain largely unknown. During encystation, genes encoding cyst wall proteins (CWPs) are coordinately up-regulated by a Myb2 transcription factor. Because cell differentiation is linked to cell cycle regulation, we tried to understand the role of cell cycle regulators, cyclin-dependent kinases (Cdks), in encystation. We found that the recombinant Myb2 was phosphorylated by Cdk-associated complexes and the levels of phosphorylation increased significantly during encystation. We have identified a putative cdk gene (cdk2) by searching th...

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Development and characterization of highly polymorphic long TC repeat microsatellite markers for genetic analysis of peanut

BMC Research Notes — Fri, 03 Feb 2012 05:00:00 +0100

Conclusions: The microsatellite markers described here are a useful resource for genetics and genomics in Arachis. In particular, the 66 markers that are highly polymorphic in cultivated peanut are a significant step towards routine genetic mapping and marker-assisted selection for the crop. (Source: BMC Research Notes)

Neurodevelopmental delay in small babies at term. A systematic review

Ultrasound in Obstetrics and Gynecology — Fri, 03 Feb 2012 05:00:00 +0100

AbstractBackground: Being small for gestational age (SGA) or having fetal growth restriction (FGR) may be associated with poorer neurodevelopmental outcomes compared to being appropriate for gestational age (AGA). The aim of this paper was to evaluate the existence and magnitude of decrease in neurodevelopmental scores in SGA and FGR infants born at term from a systematic review of the existing literature.Methods: Studies of neurodevelopment in SGA/FGR babies were identified from a search of the internet scientific databases. Studies which included preterm births and those that did not define absolute indices of standardised cognitive outcome were excluded. SGA was defined as birthweight below the 10th centile for gestation and FGR as the same birthweight standard with abnormal umbilical a...

Radio Frequency Ablation vs. Bipolar Umbilical Cord Coagulation in the Management of Complex Monochorionic Pregnancies

Ultrasound in Obstetrics and Gynecology — Fri, 03 Feb 2012 05:00:00 +0100

Living, Breathing and Teaching the Core Values of Family Medicine (Donald Woolever MD)

Family Medicine Digital Resources Library (FMDRL) Recently Uploaded — Fri, 03 Feb 2012 05:00:00 +0100

Core values of family medicine; definitions, committment, how to teach and how to measure (Source: Family Medicine Digital Resources Library (FMDRL) Recently Uploaded)

Enhancing Students' Literature Searches by Integrating Personal Librarian Feedback into a PBL Course (Suzanne Edmunds MD)

Family Medicine Digital Resources Library (FMDRL) Recently Uploaded — Fri, 03 Feb 2012 05:00:00 +0100

Peer presentation about a curriculum intervention for 1st year medical students in which they received electronic feedback from their "personal librarians" about search strategies related to learning issues in 6 PBL cases over a period of time. (Source: Family Medicine Digital Resources Library (FMDRL) Recently Uploaded)

MedWorm Sponsor Message: Find the best January Sales in the UK.

Longitudinal Approach to Teaching PubMed Search Strategy Skills to Medical Students (Harald Lausen DO)

Family Medicine Digital Resources Library (FMDRL) Recently Uploaded — Fri, 03 Feb 2012 05:00:00 +0100

(Source: Family Medicine Digital Resources Library (FMDRL) Recently Uploaded)

fmConnect: Putting Critical Pieces Together for Successful Family Medicine Student Recruitment (Judy Gary MEd)

Family Medicine Digital Resources Library (FMDRL) Recently Uploaded — Fri, 03 Feb 2012 05:00:00 +0100

Presentation given at 2012 Medical Student Education Conference (Source: Family Medicine Digital Resources Library (FMDRL) Recently Uploaded)

fmSTAT: Family Medicine Scholars Training and Admission Track (Judy Gary MEd)

Family Medicine Digital Resources Library (FMDRL) Recently Uploaded — Fri, 03 Feb 2012 05:00:00 +0100

1 General information about the VCU Department of Family Medicine fmSTAT Program 2 Description of a new dual admission program at Virginia Commonwealth University School of Medicine. 3 Sample of supplemental fmSTAT application. 4 Snapshot of curricular elements, format, and benefits of the program for participants 5 A values inventory used during the interviewing day. (Source: Family Medicine Digital Resources Library (FMDRL) Recently Uploaded)

Clerkship Projects as Supplemental Educational Tools (Suzanne Harrison MD)

Family Medicine Digital Resources Library (FMDRL) Recently Uploaded — Fri, 03 Feb 2012 05:00:00 +0100

National Survey of Clerkship Directors on projects included in clerkships; information includes types of projects, curricular themes, and examples as they relate to ACGME competencies. (Source: Family Medicine Digital Resources Library (FMDRL) Recently Uploaded)

A systematic review of the impact of foreign postings on accompanying spouses of military personnel

Nursing and Health Sciences — Fri, 03 Feb 2012 05:00:00 +0100

AbstractMilitary spouses frequently cope with separation, but limited research reviewing the impact of an overseas relocation when a spouse accompanies their serving husband/wife has been conducted. A search for studies reviewing the impact of foreign postings on these accompanying spouses was undertaken utilizing 12 databases and other resources. Ultimately, 12 studies were analyzed and four key themes produced: functioning of a military family on an international posting, loss, wellbeing and support. Overall, additional stressors are associated with an overseas posting and experiences are specific to an individual and their circumstances. Further research is required to examine the potential relationship between a spouse's experiences overseas and the impact on their health and wellbeing...

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Efficacy and safety of human urinary kallidinogenase injection for acute ischemic stroke: a systematic review

Journal of Evidence-Based Medicine — Fri, 03 Feb 2012 05:00:00 +0100

Conclusions: Available evidence suggests that HUK injection reduces neurological impairment after acute ischemic stroke and improves long‐term outcomes, though a few patients suffered from transient hypotension. Further high‐quality, large scale randomized trials are needed to confirm these results. (Source: Journal of Evidence-Based Medicine)

Silver‐coated endotracheal tube versus non‐coated endotracheal tube for preventing ventilator‐associated pneumonia among adults: A systematic review of randomized controlled trials

Journal of Evidence-Based Medicine — Fri, 03 Feb 2012 05:00:00 +0100

Conclusion: The limited evidence from meta‐analysis of two RCTs showed that using silver‐coated ETTs reduced the incidence of VAP, microbiologic burden, and device‐related adverse events among adult patients. Additional rigorous randomized trials are needed to confirm these findings. (Source: Journal of Evidence-Based Medicine)

Prevalence of non-alcoholic fatty liver disease and advanced fibrosis in Hong Kong Chinese: a population study using proton-magnetic resonance spectroscopy and transient elastography

Gut — Fri, 03 Feb 2012 05:00:00 +0100

Conclusion NAFLD is found in over a quarter of the general adult Chinese population, but the proportion of patients with advanced fibrosis is low. Modest alcohol consumption does not increase the risk of fatty liver or liver fibrosis. (Source: Gut)

Meta‐analysis of one‐ vs. two‐stage laparoscopic/endoscopic management of common bile duct stones

HPB: official journal of the International Hepato Pancreat Biliary Association — Fri, 03 Feb 2012 05:00:00 +0100

Conclusions: Outcomes after one‐stage laparoscopic/endoscopic management of bile duct stones are no different to the outcomes after two‐stage management. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)

Global malaria mortality between 1980 and 2010: a systematic analysis

NeLM - News — Fri, 03 Feb 2012 05:00:00 +0100

Source: Lancet Area: News An analysis published in the Lancet suggests that that the malaria mortality burden globally is larger than previously estimated, especially in adults. The analysis used computer modelling to build a historical database for malaria between 1980 and 2010. Global malaria deaths increased from 995,000 in 1980 to a peak of 1,817,000 in 2004, decreasing to 1,238 000 in 2010. The data show that there were 1.24 million deaths from malaria worldwide in 2010 - around twice the figure of 655 000 estimated by the World Health Organisation (WHO) for the same year. However, both the study and the WHO indicate global death rates due to malaria are now falling. A related editorial calls for urgent action to review these data and re-align priorities in malaria control. ...

MedWorm Sponsor Message: Find the best January Sales in the UK.

Use of glucocorticoids and risk of breast cancer: a Danish population-based case-control study

Breast Cancer Research — Fri, 03 Feb 2012 05:00:00 +0100

IntroductionGlucocorticoids are widely prescribed drugs. In the human body, glucocorticoid is the main stress hormone, and controls a variety of physiological and cellular processes, including metabolism and immune response. It belongs to the same steroid superfamily as estrogens, which are known to play a role in breast cancer. However, the effect of glucocorticoid use on the risk of breast cancer is not clear. Methods: We conducted a case-control study using population-based medical databases from Northern Denmark (1.8 million inhabitants) to investigate the association between glucocorticoid prescriptions and breast cancer risk. The study included 9,488 incident breast cancer cases diagnosed between 1994 and 2008 and 94,876 population controls. We estimated the odds ratios (ORs) and 95%...

Deciphering the role of Paenibacillus strain Q8 in the organic matter recycling in the acid mine drainage of Carnoules

Microbial Cell Factories — Fri, 03 Feb 2012 05:00:00 +0100

Conclusions: AMDs have been studied for years especially with regard to interactions between bacteria and the inorganic compartment hosting them. To date, no study reported the role of microorganisms in the recycling of the organic matter. The present work suggests that the strain Q8 might play an important role in the community by recycling the scarce organic matter (cellulose, hemicellulose, starch...), especially when the conditions change. Furthermore, function-based screening of a Q8 DNA library allowed to assign an amylolytic function to a gene previously unknown. AMDs could be considered as a reservoir of genes with potential biotechnological properties. (Source: Microbial Cell Factories)

Disorders of Sex Development

Springer Medicine titles — Fri, 03 Feb 2012 00:27:11 +0100

An Integrated Approach to ManagementThe birth of a baby with ambiguous genitalia triggers a chain reaction of difficulties that rapidly spread to the entire family and most medical attendants, leading to lasting effects on the gender identity, personality, and sexual functioning of the unfortunate individual. The rapid advances in medicine over the last 50 years have totally changed the outlook for children with disorders of ... (Source: Springer Medicine titles)

Serum osmolarity as an outcome predictor in hospital emergency medical admissions.

European Journal of Internal Medicine — Fri, 03 Feb 2012 00:25:42 +0100

CONCLUSION: Admission osmolarity, a simple calculation, is associated with the risk of mortality in acutely ill medical patients; deviations outside the normal range are relevant. A useful clinical predictive algorithm requires the incorporation of additional predictors. PMID: 22284254 [PubMed - in process] (Source: European Journal of Internal Medicine)

Countering health threats by chemicals with a potential terrorist background - creating a rapid alert system for Europe.

European Journal of Internal Medicine — Fri, 03 Feb 2012 00:24:52 +0100

CONCLUSION: The RAS-CHEM database works and will be integrated into the Health Emergency Operations Facility (HEOF) with other European Rapid Alert Systems. Poisons centres receive a large number of enquiries and could be important sentinels in this field of toxicovigilance. PMID: 22284259 [PubMed - in process] (Source: European Journal of Internal Medicine)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

GNU Health 1.4.3 released

GNU/Linux And Open Source Medical Software News — Thu, 02 Feb 2012 23:15:46 +0100

GNU Solidario is happy to announce the release of Health 1.4.3. This version contains many enhancements and fixes. Check at the end of this article for some important links. As a summary : - Improved menus, icons and navigation - Integrate neonatology and PSC (Pediatric Symptoms Checklist ) in a new Pediatrics menu - Now we can refer to the patient using directly the social security number, in addition to the internal health center ID - Add product categories for Insurance plans - Create initial admin rights for the main modules - Create a .mo template for each module, so we can update the transifex source language (only in the tar.gz distribution) - Added patient lastname in the party tree view - Include in the translation project in transifex many data files ( occupations, drugs, ICD-1...

Am J Physiol Renal Physiol; +22 new citations

Am J Physiol Renal P... — Thu, 02 Feb 2012 22:48:06 +0100

22 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Renal Physiol These pubmed results were generated on 2012/02/02PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Renal P...)

Semantic memory and language dysfunction in early Alzheimer's disease: a review

International Journal of Geriatric Psychiatry — Thu, 02 Feb 2012 21:34:56 +0100

ConclusionsIdentifying and classifying the nature and degree of language impairment more closely could aid in developing targeted therapies. Treatments already established in other aphasic states, such as post‐stroke, may be especially relevant. The nature of these and the protective nature of cognitive reserve are potential therapeutic avenues. Copyright © 2012 John Wiley & Sons, Ltd. (Source: International Journal of Geriatric Psychiatry)

Randomized Clinical Trial Results in PubMed

Dragonfly — Thu, 02 Feb 2012 21:22:19 +0100

Of recent interest to medical librarians is an article that was published in BMJ regarding search results in PubMed and how evidence from randomized clinical trials is retrieved. Here is some updated information from the National Library of Medicine, Bibliographic Services Division: Re: Wieland LS, Robinson KA, Dickersin K. Understanding why evidence from randomised clinical trials may not be retrieved from Medline: comparison of indexed and non-indexed records. BMJ. 2012 Jan 3;344:d7501. doi: 10.1136/bmj.d7501. PubMed PMID: 22214757. Readers of this article should recognize that the authors assumed no changes took place in the NLM indexing of Randomized Controlled Trial [publication type]. In fact, NLM has made changes since 2005 that we think affect the conclusions and projections ma...

New NLM Web Page: Disaster Apps and Mobile Optimized Web Pages

Network News — Thu, 02 Feb 2012 21:18:34 +0100

The Disaster Information Management Research Center (DIMRC) recently launched a new web page titled “Disaster Apps and Mobile Optimized Web Page”: http://disasterinfo.nlm.nih.gov/dimrc/disasterapps.html . This page includes links to various mobile tools and apps that have been selected based upon utility in a disaster or emergency context and which adhere to the National Library of Medicine’s (NLM) Selection Guidelines for non-NLM resources. The page is organized into three sections based on the type of information provided by the app or web site: Disaster Medicine Tools – tools which provide medical or health information that might be useful in preparing for, responding to, or recovering from a disaster or emergency. Disaster Resources: tools that provide informatio...

MedWorm Sponsor Message: Find the best January Sales in the UK.

New NLM Webpage: Disaster Apps and Mobile Optimized Web Pages

Network News — Thu, 02 Feb 2012 21:18:34 +0100

The Disaster Information Management Research Center (DIMRC) recently launched a new web page titled “Disaster Apps and Mobile Optimized Web Page”: http://disasterinfo.nlm.nih.gov/dimrc/disasterapps.html . This page includes links to various mobile tools and apps that have been selected based upon utility in a disaster or emergency context and which adhere to NLM’s Selection Guidelines for non-NLM resources. The page is organized into three sections based on the type of information provided by the app or web site: Disaster Medicine Tools – tools which provide medical or health information that might be useful in preparing for, responding to, or recovering from a disaster or emergency. Disaster Resources: tools that provide information on resources that may be needed in a ...

NEW TITLE IN PMC: Frontiers in Genetics

PubMed Central News — Thu, 02 Feb 2012 20:00:00 +0100

The following new journal from Frontiers Media SA has been added to PubMed Central. Frontiers in GeneticsISSN: 1662-5188 (electronic)URL: http://www.pubmedcentral.gov/tocrender.fcgi?journal=1681Archive includes v. 1 (2010) to presentNote: There is no embargo delay for this journal (Source: PubMed Central News)

Women Copy Each Others' Eating Patterns

Health News from Medical News Today — Thu, 02 Feb 2012 19:00:00 +0100

When two women are eating together, one is more likely to put food in her mouth when the other one is doing so too - while one's food-filled fork is coming towards her mouth, the other one is more likely to do the same within five seconds, researchers from Radboud University Nijmegen, the Netherlands, reported in PLoS One (The Public Library of Science 1). Behavioral mimicry, the authors suggest, occurs unwittingly during a meal. Roel Hermans, PhD... (Source: Health News from Medical News Today)

2012 HigherEd Edition of the Horizon Report is out!

The Cornflower — Thu, 02 Feb 2012 18:38:33 +0100

The 2012 HigherEd edition of the Horizon Report has been released. It can be found here: http://www.nmc.org/publications/horizon-report-2012-higher-ed-edition. Here is a summary compiled by my colleague at UIC, Ed Garay. Some key trends: 1) People expect to be able to work, learn, and study whenever and wherever they want to 2) The technologies we use are increasingly cloud-based, and our notions of IT support are decentralized 3) The world of work is increasingly collaborative, driving changes in the way student projects are structured 4) The abundance of resources and relationships made easily accessible via the Internet is increasingly challenging us to revisit our roles as educators 5) Education paradigms are shifting to include online learning, hybrid learning and collaborative ...

Outcome Following Management of Dysphagia after Laparoscopic Anti-reflux Surgery

World Journal of Surgery — Thu, 02 Feb 2012 18:12:34 +0100

Conclusions Approximately two thirds of patients with troublesome post-fundoplication dysphagia have a satisfactory outcome following either endoscopic dilatation or revisional surgery. However, approximately one third continue to be troubled by symptoms, despite further intervention. Content Type Journal ArticlePages 1-6DOI 10.1007/s00268-011-1416-9Authors Huiqi Yang, Flinders University Department of Surgery, Room 3D211, Flinders Medical Centre, Bedford Park, SA 5042, AustraliaCindy Meun, Flinders University Department of Surgery, Room 3D211, Flinders Medical Centre, Bedford Park, SA 5042, AustraliaXiangyu Sun, Flinders University Department of Surgery, Room 3D211, Flinders Medical Centre, Bedford Park, SA 5042, AustraliaDavid I. Watson, Flinders University Depart...

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Scientists sign petition to boycott academic publisher Elsevier

Guardian Unlimited Science — Thu, 02 Feb 2012 18:07:55 +0100

Cost of Knowledge petition criticises 'exorbitantly high' price of Elsevier's scientific journals and the publisher's 'huge profits'More than 3,000 academics, including several Fields medal-winning mathematicians, have put their names to a petition declaring their intention to boycott the academic publisher Elsevier.The "Cost of Knowledge" petition claims Elsevier charges "exorbitantly high" prices for its journals and criticises its practice of selling journals in "bundles" so libraries "must buy a large set with many unwanted journals, or none at all". It says the publisher makes "huge profits by exploiting their essential titles, at the expense of other journals".The petition also criticises Elsevier's support for the Stop Online Piracy Act (SOPA), PIPA and the US Research Works Act, wh...

The use of novel hemostatic sealant (Tisseel®) in laparoscopic myomectomy: a case–control study

Surgical Endoscopy — Thu, 02 Feb 2012 18:07:53 +0100

Conclusions The use of Tisseel® during LM may represent a valid alternative solution for obtaining hemostasis, reducing intra- and postoperative bleeding. Furthermore, it may help the surgeon to obtain a rapid healing of the injured surfaces, probably reducing the use of electrocoagulation and traumatisms. Content Type Journal ArticlePages 1-8DOI 10.1007/s00464-012-2154-2Authors Roberto Angioli, Department of Obstetrics and Gynecology, “Campus Bio Medico” University of Rome, Via Álvaro del Portillo, 200-00128 Rome, ItalyFrancesco Plotti, Department of Obstetrics and Gynecology, “Campus Bio Medico” University of Rome, Via Álvaro del Portillo, 200-00128 Rome, ItalyRoberto Ricciardi, Department of Obstetrics and Gynecology, “Campus Bio Medico” University...

Stereotactic radiosurgery for central neurocytoma: a quantitative systematic review

Journal of Neuro-Oncology — Thu, 02 Feb 2012 17:58:52 +0100

Abstract Central neurocytoma was originally described as a rare benign neuronal tumor. However, progression and local recurrences after surgery are well recognized. Stereotactic radiosurgery is another option for treatment of CN. In order to evaluate the efficacy of SRS, we performed a quantitative systematic review of the available data on SRS for CN. To identify eligible studies, systematic searches for all CNs treated with SRS were conducted in major scientific publication databases. English studies published prior to May 2011 were reviewed and summarized with reference to the inclusion and exclusion criteria. Tumor local control was analyzed. Heterogeneity and publication bias were assessed, and the summary control rate and 95% confidence interval (CI) were calculated ...

Young Children Exposed to Anesthesia Multiple Times Show Elevated Rates of ADHD

News from Mayo Clinic — Thu, 02 Feb 2012 17:40:21 +0100

Mayo Clinic researchers have found that multiple exposures to anesthesia at a young age are associated with higher rates of attention-deficit/hyperactivity disorder (ADHD). (Source: News from Mayo Clinic)

When doctors ditch pens, medical errors drop

ICMCC: The International Council on Medical and Care Compunetics — Thu, 02 Feb 2012 16:35:29 +0100

Source: Sarah Kliff, The Washington Post Content: “There’s a lot of interest in health care right now in digitizing doctors’ decision-making, using computer databases to assist in diagnoses and treatments (Exhibit A: Wellpoint’s pilot project using Dr. Watson, the Jeopardy-winning super-computer, to assist doctors in the exam room). NPR flags new research that underscores how [...] (Source: ICMCC: The International Council on Medical and Care Compunetics)

MedWorm Sponsor Message: Find the best January Sales in the UK.

Contemporary Status of Home Dialysis in Japan

Karger Publishers — Thu, 02 Feb 2012 15:51:22 +0100

ISBN: (Source: Karger Publishers)

New online databases help patients find adverse event

ICMCC: The International Council on Medical and Care Compunetics — Thu, 02 Feb 2012 14:44:49 +0100

Source: Sara Jackson, FierceHealthIT Content: “Two health IT startups aim to help patients sift through the reams of adverse event data collected by the U.S. Food and Drug Administration, according to a report today in the Wall Street Journal. The two companies, AdverseEvents and Clarimed, have developed websites backed by algorithms that sort FDA adverse event [...] (Source: ICMCC: The International Council on Medical and Care Compunetics)

Differences in Treatment Patterns and Outcomes Between Hispanics and Non-Hispanic Whites Treated for ST-Segment Elevation Myocardial Infarction: Results From the NCDR ACTION Registry–GWTG

Journal of the American College of Cardiology — Thu, 02 Feb 2012 13:55:34 +0100

To the Editor: Ethnic disparities in contemporary ST-segment elevation myocardial infarction (STEMI) management have not been well characterized (). The National Cardiovascular Data Registry Acute Coronary Treatment and Intervention Outcome Network–Get With The Guidelines Registry (ACTION Registry–GWTG) is the largest national database including consecutive acute coronary syndrome patients from all U.S. geographic regions and therefore provides a unique opportunity to compare contemporary treatment patterns and outcomes between Hispanic and non-Hispanic white STEMI patients. (Source: Journal of the American College of Cardiology)

Sex-Related Differences in Clinical Presentation and Outcome of Transcatheter Aortic Valve Implantation for Severe Aortic Stenosis

Journal of the American College of Cardiology — Thu, 02 Feb 2012 13:55:34 +0100

Conclusions: Female sex is associated with better baseline clinical characteristics and improved survival, and is identified as a predictor of midterm survival after TAVI. (Source: Journal of the American College of Cardiology)

Nature Launches Global Scientific Calendar

What's New on JEFFLINE — Thu, 02 Feb 2012 13:00:46 +0100

Nature Publishing Group (NPG) has launched an online calendar of global scientific events. The calendar provides users with a new way to search for science events, which can also be personalized and synced to a personal online or mobile calendar. The calendar is hosted on nature.com; it is free both to view and to contribute to. The calendar provides users with an innovative way to find important dates in science, as well as events that have been specifically selected by Nature editors. Content includes: Conferences Training courses Careers events Journal publication dates International observances Congress Historical anniversaries Astronomical events Webinars/virtual events Users can synchronize their personal calendar automatically with the events calendar using the iCal feed. Feeds...

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Genetic variations in CHRNA7 or CHRFAM7 and susceptibility to dementia.

Current Drug Targets — Thu, 02 Feb 2012 05:00:00 +0100

Authors: Neri M, Bonassi S, Russo P Abstract The presence of memory impairment and cognitive deficits in the Alzheimer's disease (AD), dementia with Lewy bodies (DLB), and Pick's disease (PiD) has been associated to dysfunction of cholinergic transmission, possibly due to the loss of cholinergic neurons and to the elimination of nAChR in dementia patients. Alternative hypotheses take into account molecular interactions of the β-amyloid peptide Aβ with nAChR, which may lead to deregulation of the receptor function. Genetic polymorphisms of CHRNA7 and CHRFAM7A, a fusion gene containing a partial CHRNA7 duplication, have been investigated as possible susceptibility traits to dementia, potentially useful either to identify high risk individuals or as therapeutic targets. To summarize...

Professionalism Education: Making a Difference vs. Finding a Deviance (Stephanie Cizek BS)

Family Medicine Digital Resources Library (FMDRL) Recently Uploaded — Thu, 02 Feb 2012 05:00:00 +0100

(Source: Family Medicine Digital Resources Library (FMDRL) Recently Uploaded)

Lack of association between human Oxoguanine Glycosylase 1 (hOGG1) S326C polymorphism and the risk of gastric cancer: a meta-analysis.

Neoplasma — Thu, 02 Feb 2012 05:00:00 +0100

Authors: Ding R, Chen DJ, Lin SL Abstract Results from published studies on the association of Human Oxoguanine Glycosylase 1 (hOGG1) S326C genetic polymorphism with the risk of gastric cancer are inconsistent. We performed a meta-analysis to summarize the possible association. Eleven case-control studies including 2168 cases and 4058 controls were identified from electronic databases (Pubmed, Elsevier Science Direct, Chinese National Knowledge Infrastructure (CNKI), Chinese Biomedical Literature Database (CBM), and the Chinese database, Wanfang). No significant association between hOGG1 S326C genetic polymorphism and risk of gastric cancer was observed in the overall analysis. In the stratified analysis based on ethnicity, still no significant association was observed in Europea...

Bezafibrate for primary biliary cirrhosis

NeLM - Drug Specific Reviews — Thu, 02 Feb 2012 05:00:00 +0100

Source: Cochrane Library Area: Evidence > Drug Specific Reviews Background Treatment of primary biliary cirrhosis is complicated. There are studies suggesting that bezafibrate, alone or in combination with ursodeoxycholic acid (UDCA), is effective in the treatment of primary biliary cirrhosis, but no systematic review has summarised the evidence yet. Objectives To assess the beneficial and harmful effects of bezafibrate in patients with primary biliary cirrhosis. Search methods The Cochrane Hepato-Biliary Group Controlled Trials Register, The Cochrane Central Register of Controlled Trials (CENTRAL) in The Cochrane Library, MEDLINE, EMBASE, Science Citation Index Expanded, LILACS, Clinicaltrials.gov, the WHO International Clinical Trials ...

Interferon beta for secondary progressive multiple sclerosis

NeLM - Drug Specific Reviews — Thu, 02 Feb 2012 05:00:00 +0100

Source: Cochrane Library Area: Evidence > Drug Specific Reviews Background Therapy with either recombinant beta-1a or beta-1b interferons (IFNs) is worldwide approved for Relapsing Remitting Multiple Sclerosis (RRMS). A major unanswered question is whether this treatment is able to safely reverse or retard the progressive phase of the disease. Objectives The main objective was to verify whether IFNs treatment in Secondary Progressive Multiple Sclerosis (SPMS) is more effective than placebo in reducing the number of patients who experience disability progression. Search methods We searched the Cochrane Multiple Sclerosis Group's Trials Register (1995 to 15 February 2011), the reference lists of relevant articles and conference proceedings. Reg...

MedWorm Sponsor Message: Find the best January Sales in the UK.

Interventions for fatigue and weight loss in adults with advanced progressive illness

NeLM - Drug Specific Reviews — Thu, 02 Feb 2012 05:00:00 +0100

Source: Cochrane Area: Evidence > Drug Specific Reviews Background Fatigue and unintentional weight loss are two of the commonest symptoms experienced by people with advanced progressive illness. Appropriate interventions may bring considerable improvements in function and quality of life to seriously ill people and their families, reducing physical, psychological and spiritual distress. Objectives To conduct an overview of the evidence available on the efficacy of interventions used in the management of fatigue and/or unintentional weight loss in adults with advanced progressive illness by reviewing the evidence contained within Cochrane reviews. Methods We searched the Cochrane Database of Systematic Reviews (CDSR) for all systematic re...

Intracutaneous or subcutaneous sterile water injection compared with blinded controls for pain management in labour

NeLM - Drug Specific Reviews — Thu, 02 Feb 2012 05:00:00 +0100

Source: Cochrane Library Area: Evidence > Drug Specific Reviews Background Intracutaneous or subcutaneous injection of sterile water is rapidly gaining popularity as a method of pain relief in labour and it is therefore essential that it is properly evaluated. Adequate analgesia in labour is important to women worldwide. Sterile water injection is inexpensive, requires basic equipment, and appears to have few side effects. It is purported to work for labour pain. Objectives To determine the efficacy of sterile water injections for relief of pain (both typical contraction pain and intractable back pain) during labour compared to placebo (isotonic saline injections) or non-pharmacological interventions, and to identify any relevant effects on mode and timing of delivery, or ...

Androgenic suppression combined with radiotherapy for the treatment of prostate adenocarcinoma: a systematic review

BMC Cancer — Thu, 02 Feb 2012 05:00:00 +0100

Conclusions: Based on the findings of this systematic review, the evidence supports the use of androgen suppression with goserelin monotherapy as the standard treatment for patients with prostate cancer treated with radiotherapy, which are at high risk of recurrence or metastases. (Source: BMC Cancer)

Quercetin-3-methyl ether suppresses proliferation of mouse epidermal JB6 P+ cells by targeting ERKs

Carcinogenesis — Thu, 02 Feb 2012 05:00:00 +0100

Chemoprevention has been acknowledged as an important and practical strategy for the management of skin cancer. Quercetin-3-methyl ether, a naturally occurring compound present in various plants, has potent anticancer-promoting activity. We identified this compound by in silico virtual screening of the Traditional Chinese Medicine Database using extracellular signal-regulated kinase 2 (ERK2) as the target protein. Here, we showed that quercetin-3-methyl ether inhibited proliferation of mouse skin epidermal JB6 P+ cells in a dose- and time-dependent manner by inducing cell cycle G2–M phase accumulation. It also suppressed 12-O-tetradecanoylphorbol-13-acetate-induced neoplastic cell transformation in a dose-dependent manner. Its inhibitory effect was greater than quercetin. The activat...

Do Prescription Monitoring Programs Impact State Trends in Opioid Abuse/Misuse?

Pain Medicine — Thu, 02 Feb 2012 05:00:00 +0100

Conclusions. Two observational data sources offer preliminary support that PMPs are effective. Future efforts should evaluate what PMP characteristics are most effective and which opioids are most impacted. (Source: Pain Medicine)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Qualitative and semi-quantitative analysis of Lactobacillus species in vagina of healthy fertile and postmenopausal Chinese women.

Journal of Medical Microbiology — Thu, 02 Feb 2012 05:00:00 +0100

In conclusion, this study provided detailed information on Lactobacillus species colonizing the vagina of healthy Chinese fertile and postmenopausal women. The study also showed that the diversity of Lactobacillus species in fertile women was higher than in postmenopausal women. According to our study, different techniques such as species-specific PCR and clone library resulted in different findings regarding species prevalence. This fact lightens the importance of standardization of techniques used for evaluation of bacterial communities. According to our findings regarding species associations, L. iners and L. gasseri may have influences on colonization and proliferation of other vaginal Lactobacillus species. PMID: 22301614 [PubMed - as supplied by publisher] (Source: Journal of Med...

Human anti-EGFL7 recombinant full-length antibodies selected from a mammalian cell-based antibody display library.

Molecular and Cellular Biochemistry — Thu, 02 Feb 2012 05:00:00 +0100

We describe here the isolation of an EGFL7-specific antibody from a mammalian cell-based full-length antibody display library generated from peripheral blood mononuclear cells of patients with hepatocellular carcinoma. Using a novel vector, contained glycosylphosphatidylinositol anchor and restriction enzyme sites NheI and ClaI, antibody libraries are displayed as whole IgG molecules on the cell surface and screened for specific antigen binding by a combination of magnetic beads and measured by cell ELISA. Anti-EGFL7 antibody was successfully isolated from the library. The mammalian cell-based full-length antibody display library is a great potential application for rapid identification and cloning of human mAbs of targeting hepatocellular carcinoma. PMID: 22297616 [PubMed - as supplie...

Researchers boycott Elsevier

Physics Today News Picks — Thu, 02 Feb 2012 05:00:00 +0100

Chronicle of Higher Education: The latest development in the controversy concerning open access to scholarly research is the boycott of Elsevier, the world's largest scientific journal publisher. By Tuesday evening about 2400 scientists had signed an online pledge not to publish or do any editorial work for the company's journals, writes Josh Fischman for the Chronicle of Higher Education. It began with an irate blog post on 21 January by Timothy Gowers, a mathematician at the University of Cambridge. The boycotters claim that Elsevier charges too much for journal content, that its bundling of subscriptions forces libraries to pay for journals they don't want in order to get the ones they do, and that the company is a strong supporter of the Research Works Act. Representatives of Else...

Differences of Z chromosome and genomic expression between early- and late-feathering chickens.

Molecular Biology Reports — Thu, 02 Feb 2012 05:00:00 +0100

This study suggested that increasing PRLR expression that resulted from the special variant on chicken Z chromosome caused the late-feathering phenotype. PMID: 22297689 [PubMed - as supplied by publisher] (Source: Molecular Biology Reports)

Expression characteristics of two ubiquitin/ribosomal fusion protein genes in the developing testis, accessory gonad and ovary of Chinese mitten crab, Eriocheir sinensis.

Molecular Biology Reports — Thu, 02 Feb 2012 05:00:00 +0100

Authors: Wang Q, Chen L, Wang Y, Li W, He L, Jiang H Abstract The ubiquitin/proteasome pathway plays an important role in gametogenesis. Ubiquitin/ribosomal fusion protein is the precursor of mono-ubiquitin. We identified two ubiquitin/ribosomal fusion proteins genes in testis of Eriocheir sinensis. The ubiquitin-ribosomal proteins S27 and L40 are denoted as UBS27 and UBL40, respectively. The full length Es-UBS27 cDNA (565 bp) was cloned using PCR, based upon an initial expressed sequence tag (EST) isolated from a testicular cDNA library and the result of 3' RACE. The sequence contained a 465-nucleotide open reading frame (ORF) that encoded a protein of 154 amino acids. It contained a Ubiquitin (UB) domain and the ribosomal protein S27. The full-length Es-UBL40 cDNA (521 bp) cont...

MedWorm Sponsor Message: Find the best January Sales in the UK.

ACE2 gene polymorphism and essential hypertension: an updated meta-analysis involving 11,051 subjects.

Molecular Biology Reports — Thu, 02 Feb 2012 05:00:00 +0100

Authors: Lu N, Yang Y, Wang Y, Liu Y, Fu G, Chen D, Dai H, Fan X, Hui R, Zheng Y Abstract The polymorphisms of angiotensin-converting enzyme 2 (ACE2) gene have been suggested to be linked to increase risk of essential hypertension in multiple populations. However, the results are still debatable. To assess the association between ACE2 G8970A genetic polymorphism and essential hypertension, we conducted a meta-analysis of case-control studies across different ethnicity. PubMed, Embase, CBM, Wanfang and VIP databases were searched, and a total of 11 separate studies in females and nine separate studies in males met the inclusion criteria. Because ACE2 is on the X chromosome, data for each sex were analyzed separately. The selected studies contained 7,251 (4,472 females/2,779 males) h...

Comparison of Inside-Out and All-Inside Techniques for the Repair of Isolated Meniscal Tears: A Systematic Review

The American Journal of Sports Medicine — Thu, 02 Feb 2012 05:00:00 +0100

Conclusion: There are no differences in clinical failure rate or subjective outcome between inside-out and all-inside meniscus repair techniques. Complications are associated with both techniques. More nerve symptoms are associated with the inside-out repair and more implant-related complications are associated with the all-inside technique. Clinical Relevance: Rates of structural healing and complications are comparable for inside-out and all-inside repair techniques for isolated meniscal injury. Differences in observed healing rates after meniscal repair may be more dependent on tear pattern and associated anterior cruciate ligament reconstruction rather than an inside-out versus all-inside surgical approach. (Source: The American Journal of Sports Medicine)

Long-term Results of Surgical Decompression of Chronic Exertional Compartment Syndrome of the Forearm in Motocross Racers

The American Journal of Sports Medicine — Thu, 02 Feb 2012 05:00:00 +0100

Conclusion: Surgical fasciotomy and fasciectomy of the forearm flexor compartment are equally successful in motocross racers suffering from forearm CECS. (Source: The American Journal of Sports Medicine)

Community Preceptor Payment and Recruitment (Lisa Slatt MEd)

Family Medicine Digital Resources Library (FMDRL) Recently Uploaded — Thu, 02 Feb 2012 05:00:00 +0100

Results of a survey of clerkship directors on issues relating to recruitment and payment of community practices used in clerkship teaching. (Source: Family Medicine Digital Resources Library (FMDRL) Recently Uploaded)

Asian age‐related macular degeneration phenotyping study: rationale, design and protocol of a prospective cohort study

Clinical and Experimental Ophthalmology — Thu, 02 Feb 2012 05:00:00 +0100

Conclusions: This study will provide in‐depth longitudinal data of the evolution of clinical features, risk factors, natural history and treatment pattern and response of Asian age‐related macular degeneration and polypoidal choroidovasculopathy, allowing unique insights into pathogenesis and the design of new treatment strategies.© 2012 The Authors. Journal compilation © 2012 Royal Australian and New Zealand College of Ophthalmologists (Source: Clinical and Experimental Ophthalmology)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

An assessment of the accuracy and availability of data in electronic patient tracking systems for patients receiving HIV treatment in central Mozambique

BMC Health Services Research — Thu, 02 Feb 2012 05:00:00 +0100

Conclusions: Electronic patient tracking systems have been deployed to respond to the growing monitoring, evaluation and reporting requirements. In our cross-sectional study of clinics in Manica and Sofala provinces of Mozambique, we found high levels of completeness and reliability for key variables indicating that these electronic databases provided adequate data not only for monitoring and evaluation but also for research. Routine evaluations of the completeness and reliability of these databases need to occur to ensure high quality data are being used for reporting and research. (Source: BMC Health Services Research)

A small molecule screening strategy with validation on human leukemia stem cells uncovers the therapeutic efficacy of kinetin riboside

Blood — Thu, 02 Feb 2012 05:00:00 +0100

Gene regulatory networks that govern hematopoietic stem cells (HSCs) and leukemia-initiating cells (L-ICs) are deeply entangled. Thus, the discovery of compounds that target L-ICs while sparing HSC is an attractive but difficult endeavor. Presently, most screening approaches fail to counter-screen compounds against normal hematopoietic stem/progenitor cells (HSPCs). Here, we present a multistep in vitro and in vivo approach to identify compounds that can target L-ICs in acute myeloid leukemia (AML). A high-throughput screen of 4000 compounds on novel leukemia cell lines derived from human experimental leukemogenesis models yielded 80 hits, of which 10 were less toxic to HSPC. We characterized a single compound, kinetin riboside (KR), on AML L-ICs and HSPCs. KR demonstrated comparable effic...

Rational opioid dosing in the elderly: dose and dosing interval when initiating opioid therapy

NeLM - Care of Older People — Thu, 02 Feb 2012 05:00:00 +0100

Source: Clinical Pharmacology and Therapeutics Area: Evidence > Medicines Management > References Opioids are the mainstay of treatment for moderate to severe pain. However, opioid therapy in the elderly is often associated with significant morbidity because of excessive ventilatory depression. The large amount of interindividual variability in opioid dose-response relationships makes it difficult to individualise the dose and dosing interval to provide safe and effective analgesia. By examining how aging affects the pharmacokinetics (PK) and pharmacodynamics (PD) of opioids, it is possible to provide a rational basis for age adjustment in opioid dosing. Authors conclude that 'simulations with PK-PD models confirm the clinical impression that elderly patients n...

Reducing the burden of morbidity and medical utilization of older patients by outpatient geriatric services: Implications to primary health‐care settings

Geriatrics and Gerontology International — Thu, 02 Feb 2012 05:00:00 +0100

Conclusion: Outpatient GEM could effectively reduce growth of BOM and medical utilization for relatively healthy elderly patients in Taiwan where elderly patients haverelatively free access to general and specialty care. The results of this study implied the potential benefits of systematically implementing GEM in primary health‐care settings to improve the quality of care and slow down the growth of BOM for elderly patients. Geriatr Gerontol Int 2012; ••: ••–••. (Source: Geriatrics and Gerontology International)