MedWorm: Dermatology

Psoriasis not independently linked to ischemic heart disease

MedWire News - Psoriasis — Sat, 07 Nov 2009 13:59:13 +0100

Psoriasis may not be a clinical risk factor for ischemic heart disease hospitalization, Dutch study findings suggest. (Source: MedWire News - Psoriasis)

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Psoriasis not independently linked to ischemic heart disease

MedWire News - Dermatology — Sat, 07 Nov 2009 13:59:13 +0100

Psoriasis may not be a clinical risk factor for ischemic heart disease hospitalization, Dutch study findings suggest. (Source: MedWire News - Dermatology)

Novexel Starts Phase II Clinical Trial With NXL103 In Adults With Acute Bacterial Skin And Skin Structure Infections (ABSSSI)

Dermatology News From Medical News Today — Sat, 07 Nov 2009 09:00:00 +0100

Novexel, a speciality pharmaceutical company focused on the discovery and development of novel antibiotics designed to overcome the significant global problem of microbial resistance, announces that its most advanced oral antibacterial NXL103 (flopristin/linopristin), has started a Phase II clinical trial in adults with acute bacterial skin and skin structure infections (ABSSSI). (Source: Dermatology News From Medical News Today)

Theravance And Astellas Announce The Commercial Launch Of VIBATIVTM (telavancin) In The United States

Dermatology News From Medical News Today — Fri, 06 Nov 2009 18:00:00 +0100

Theravance, Inc. (NASDAQ: THRX) and Astellas Pharma US, Inc. announced today the commercial launch of VIBATIV™ (telavancin) in the United States. On September 11, 2009, the U.S. Food and Drug Administration (FDA) approved VIBATIV for the treatment of adult patients with complicated skin and skin structure infections (cSSSI) caused by susceptible Gram-positive bacteria, including Staphylococcus aureus, both methicillin-resistant (MRSA) and methicillin-susceptible (MSSA) strains. (Source: Dermatology News From Medical News Today)

Lichen Planus and dyslipidaemia: a Case–control Study

Medscape Dermatology Headlines — Fri, 06 Nov 2009 13:33:08 +0100

This case study investigates the association between lichen planus and dyslipidaemia. The British Journal of Dermatology (Source: Medscape Dermatology Headlines)

Post surgical radiotherapy lowers lymph node recurrence in melanoma patients

MedWire News - Dermatology — Fri, 06 Nov 2009 00:00:00 +0100

Results from a randomized trial show that high-risk melanoma patients who undergo radiotherapy following lymphadenectomy surgery have a reduced risk for further regional relapse. (Source: MedWire News - Dermatology)

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Gestational diabetes increases risk for infant atopic dermatitis

MedWire News - Dermatology — Fri, 06 Nov 2009 00:00:00 +0100

Exposure to gestational diabetes increases the risk for atopic dermatitis and early childhood allergen sensitization in babies born at term, report US researchers. (Source: MedWire News - Dermatology)

Essentials of dermatology - for all sections of medical fraternity-D M Thappa

Indian Journal of Dermatology — Thu, 05 Nov 2009 14:03:54 +0100

Sengupta S RIndian Journal of Dermatology 2009 54(4):393-393 (Source: Indian Journal of Dermatology)

Sanitary pad dermatitis

Indian Journal of Dermatology — Thu, 05 Nov 2009 14:03:54 +0100

Wiwanitkit VirojIndian Journal of Dermatology 2009 54(4):391-392 (Source: Indian Journal of Dermatology)

Simultaneous co-occurrence of porokeratosis of mibelli with disseminated superficial actinic porokeratosis

Indian Journal of Dermatology — Thu, 05 Nov 2009 14:03:54 +0100

Mehta Vandana, Balachandran CIndian Journal of Dermatology 2009 54(4):390-391 (Source: Indian Journal of Dermatology)

Idiopathic calcinosis cutis

Indian Journal of Dermatology — Thu, 05 Nov 2009 14:03:54 +0100

Lanka Padmavathy, Lanka Lakshmana Rao, Ethirajan N, Krishnaswamy B, Manohar UIndian Journal of Dermatology 2009 54(4):388-389 (Source: Indian Journal of Dermatology)

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Malignant melanoma with a seborrheic keratosis-like clinical presentation

Indian Journal of Dermatology — Thu, 05 Nov 2009 14:03:54 +0100

Haruna Kunitaka, Suga Yasushi, Mizuno Yuki, Ikeda ShigakuIndian Journal of Dermatology 2009 54(4):387-388 (Source: Indian Journal of Dermatology)

Species identification of Candida isolates obtained from oral lesions of HIV infected patients

Indian Journal of Dermatology — Thu, 05 Nov 2009 14:03:54 +0100

Baradkar V P, Kumar SIndian Journal of Dermatology 2009 54(4):385-386A total of 60 patients suspected to have AIDS with oral lesions suggestive of oral candidiasis were studied. Candida species were isolated from 50 patients. Candida albicans was the commonest isolate (70 %) followed Candida parapsilosis (15%), Candida glabrata (7.5%) and Candida tropicalis (5%) respectively. Candida dubliniensis was isolated from a single case only. Though the reports from developed countries show mor...

Cutaneous zygomycosis due to Saksenaea vasiformis in an immunocompetent host

Indian Journal of Dermatology — Thu, 05 Nov 2009 14:03:54 +0100

Baradkar V P, Kumar SIndian Journal of Dermatology 2009 54(4):382-384Saksenaea vasiformis is an emerging zygomycete species, most often associated with cutaneous, subcutaneous and rhino- orbito-cerebral infections. Herein, we report a case of cutaneous zygomycosis of face caused by Saksenaea vasiformis in a 54-year-old immunocompetent female. The diagnosis was carried out by microscopy using KOH mount, Gram staining, Gomori's methenamine silver staining, hemotoxylin and eosin staining and culture on Sabouraud's Dextrose agar without actidione. Slide cultures were put up on Czapek Dox agar, which showed typical flask-shaped sporangium with rhizoids. The patient was treated successful...

Recurrent ovarian malignancy presenting as cutaneous metastasis

Indian Journal of Dermatology — Thu, 05 Nov 2009 14:03:54 +0100

We report the case of the woman who presented to us with clitoral nodules and skin nodules. Histopathological examination of nodules confirmed the diagnosis of metastasis of an ovarian carcinoma. Despite poor prognosis, the patient responded and survived well beyond the expected four months survival of similar cases. (Source: Indian Journal of Dermatology)

Hyper IgE syndrome with umbilical hernia

Indian Journal of Dermatology — Thu, 05 Nov 2009 14:03:54 +0100

Hiremath N C, Madan Mohan N T, Srinivas C, Sangolli Prabhakar M, Srinivas K, Soumya NIndian Journal of Dermatology 2009 54(4):378-379Hyper IgE Syndrome (HIES) is a rare multi system genetic immunodeficiency disorder, with immunological and non-immunological features. Immunolgical features are 1) Recurrent cutaneous abscesses, 2) Atopic dermatitis like lesions, 3) Sino pulmonary infections, 4) Elevated serum IgE levels and 5) Abnormal neutrophil chemotaxis. Non immunological features include cranio facial and skeletal abnormalities. We are reporting a girl with classical features of HIES with umbilical hernia with her younger brother suffering from right sided inguinal hernia, as both herniae are hitherto unreported in patients with HIES. (Source: Indian Journal of Dermatology)

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Cutis marmorata telangiectatica congenita with skin ulcerations in a new born

Indian Journal of Dermatology — Thu, 05 Nov 2009 14:03:54 +0100

Chatterjee Rita, Dey SubhenduIndian Journal of Dermatology 2009 54(4):375-377Cutis marmorata telangiectatica congenita (CMTC) is a rare congenital disorder with persistent cutis marmorata, telengiectasia, and phlebectesia, which may be associated with cutaneaus atrophy and ulceration of the involved skin. We herewith report a full-term newborn female baby with CMTC at birth with ulceration over the extensor aspects of both the knee joints and right elbow joint. CMTC is a benign vascular anomaly representing dilatation of capillaries and veins of dermis and is apparent at birth. The baby had a reticulated bluish purple skin changes all over the body including the face and limb. Although it resembled physiological cutis marmorata, it was strikingly pronounced and definitely was unvarying and...

Rare association of hyper IgE syndrome with cervical rib and natal teeth

Indian Journal of Dermatology — Thu, 05 Nov 2009 14:03:54 +0100

We report here a classical case of HIES with rare associations of natal teeth, bilateral cervical ribs, and conductive deafness. The patient was being treated with monteleukast and dapsone. (Source: Indian Journal of Dermatology)

Diffuse plane xanthomatosis in a patient with Budd-Chiari syndrome and monoclonal gammopathy

Indian Journal of Dermatology — Thu, 05 Nov 2009 14:03:54 +0100

We present a case of diffuse plane xanthoma in a 62-year-old man who developed normolipemic plane xanthomas coinciding with Budd-Chiari syndrome and monoclonal gammopathy. We review the English-language literature regarding the rare association of xanthomas and Budd-Chiari syndrome. (Source: Indian Journal of Dermatology)

Comparative evaluation of long pulse alexandrite laser and intense pulsed light systems for pseudofolliculitis barbae treatment with one year of follow up

Indian Journal of Dermatology — Thu, 05 Nov 2009 14:03:54 +0100

Conclusions: Our results showed that both systems might improve PFB but Alexandrite laser was more effective at reducing PFB than IPL. (Source: Indian Journal of Dermatology)

Treatment of periocular hyperpigmentation due to lead of kohl (surma) by penicillamine: A single group non-randomized clinical trial

Indian Journal of Dermatology — Thu, 05 Nov 2009 14:03:54 +0100

Conclusion: Regardless other causes, this study spots the light on a new concept for periocular hyperpigmentation from lead toxicity in adult females using kohl and suggests D-PCN in a low divided dose (750 mg/day) for its treatment. (Source: Indian Journal of Dermatology)

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Vitiligo treatment with vitamins, minerals and polyphenol supplementation

Indian Journal of Dermatology — Thu, 05 Nov 2009 14:03:54 +0100

Conclusion: Our findings suggest that an antioxidant supplementation is significantly beneficial in contributing superior clinical efficacy to cure vitiligo. (Source: Indian Journal of Dermatology)

Efficacy and tolerability of cefditoren pivoxil in uncomplicated skin and skin structure infections in Indian patients

Indian Journal of Dermatology — Thu, 05 Nov 2009 14:03:54 +0100

Conclusion: Cefditoren pivoxil 200 mg b.i.d. was effective and well tolerated in the treatment of uSSSI. (Source: Indian Journal of Dermatology)

Pattern of sexually transmitted infections in a tertiary care centre at Puducherry

Indian Journal of Dermatology — Thu, 05 Nov 2009 14:03:54 +0100

Conclusions: Herpes genitalis was the most common ulcerative STD, while genital wart was the most common nonulcerative STI in our study. The prevalence of HIV among STI clients in India has been on the rise, but has quite alarmingly become the most common STI in our study. (Source: Indian Journal of Dermatology)

Recurrence pattern in squamous cell carcinoma of skin of lower extremities and abdominal wall (Kangri cancer) in Kashmir valley of Indian subcontinent: Impact of various treatment modalities

Indian Journal of Dermatology — Thu, 05 Nov 2009 14:03:54 +0100

Conclusion: Post operative radiotherapy significantly decreases the loco-regional recurrences and a trial of prophylactic nodal irradiation is justified in a selected group of such patients. (Source: Indian Journal of Dermatology)

Dermatological manifestations in HIV-infected patients at a tertiary care hospital in a tribal (Bastar) region of Chhattisgarh, India

Indian Journal of Dermatology — Thu, 05 Nov 2009 14:03:54 +0100

Conclusion : This study showed high prevalence of dermatological manifestations in HIV-infected subjects, and they occur more frequently with progression of HIV and decline in immune functions. Therefore, early diagnosis and management of skin disorders can improve the quality of life of HIV-infected subjects. (Source: Indian Journal of Dermatology)

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Familial reactive perforating collagenosis

Indian Journal of Dermatology — Thu, 05 Nov 2009 14:03:54 +0100

Conclusion: Oral and topical retinoids in combination with emollients is the best treatment option. (Source: Indian Journal of Dermatology)

Dermatology life quality index scores in vitiligo: Reliability and validity of the Tunisian version

Indian Journal of Dermatology — Thu, 05 Nov 2009 14:03:54 +0100

Conclusions: The study findings showed that the Tunisian version of the DLQI questionnaire has a good structural characteristic and is a reliable and valid instrument that can be used for measuring the effects of vitiligo on quality of life. (Source: Indian Journal of Dermatology)

Photo-stimulatory effect of low energy helium-neon laser irradiation on excisional diabetic wound healing dynamics in wistar rats

Indian Journal of Dermatology — Thu, 05 Nov 2009 14:03:54 +0100

Conclusion: The biochemical analysis and clinical observation suggested that 3-6 J/cm 2 laser photo stimulation facilitates the tissue repair process by accelerating collagen production in diabetic wound healing. (Source: Indian Journal of Dermatology)

Quantitation of mast cells and collagen fibers in skin tags

Indian Journal of Dermatology — Thu, 05 Nov 2009 14:03:54 +0100

Conclusion: The positive correlation between mast cell count and percentage of collagen mean area suggests the critical role of mast cells in the etiogenesis of skin tags through its interaction with fibroblasts. (Source: Indian Journal of Dermatology)

Vitiligo and the melanocyte reservoir

Indian Journal of Dermatology — Thu, 05 Nov 2009 14:03:54 +0100

Falabella RafaelIndian Journal of Dermatology 2009 54(4):313-318Repigmentation of vitiligo depends on available melanocytes from three possible sources: from the hair follicle unit which is the main provider of pigment cells, from the border of vitiligo lesions, and from unaffected melanocytes within depigmented areas; pigment cells at these locations originate a perifollicular, border spreading and a diffuse repigmentation pattern. In order for repigmentation to take place under stimulation with diverse therapies, melanocytes should be present in appropriate numbers. Melanocyte tissue stem cells located in the niche at the bulge region of the hair follicle are the most important sources for providing immature pigment cells that undergo terminal differentiation and originate repigmentation...

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Chronic urticaria and treatment options

Indian Journal of Dermatology — Thu, 05 Nov 2009 14:03:54 +0100

Godse Kiran VasantIndian Journal of Dermatology 2009 54(4):310-312Chronic urticaria has a wide spectrum of clinical presentations and causes. Still, despite our best efforts no cause may be found in the majority of cases. The treatment options are: Primary prevention in the form of avoidance of aggravating factors; counseling; antihistamines; leukotriene receptor antagonists; prednisolone; sulfasalazine and a host of immunosuppressives like methotrexate, cyclosporine, omalizumab etc. (Source: Indian Journal of Dermatology)

Topical treatment of melasma

Indian Journal of Dermatology — Thu, 05 Nov 2009 14:03:54 +0100

Bandyopadhyay DebabrataIndian Journal of Dermatology 2009 54(4):303-309Melasma is a common hypermelanotic disorder affecting the face that is associated with considerable psychological impacts. The management of melasma is challenging and requires a long-term treatment plan. In addition to avoidance of aggravating factors like oral pills and ultraviolet exposure, topical therapy has remained the mainstay of treatment. Multiple options for topical treatment are available, of which hydroquinone (HQ) is the most commonly prescribed agent. Besides HQ, other topical agents for which varying degrees of evidence for clinical efficacy exist include azelaic acid, kojic acid, retinoids, topical steroids, glycolic acid, mequinol, and arbutin. Topical medications modify various stages of melanogenesis...

Cellulitis

MedicineNet Skin General — Thu, 05 Nov 2009 07:00:00 +0100

Title: CellulitisCategory: Diseases and ConditionsCreated: 12/3/1999 2:59:00 PMLast Editorial Review: 11/5/2009 (Source: MedicineNet Skin General)

Janssen issues letter about reports of toxic epidermal necrolysis and DRESS syndrome associated with etravirine (Intelence®)

NeLM - Dermatology — Thu, 05 Nov 2009 00:00:00 +0100

Source: MHRA Area: News In agreement with the EMEA, Janssen has issued a letter to healthcare professionals about cases of toxic epidermal necrolysis (TEN), one of which resulted in fatality and cases of drug rash with eosinophilia and systemic symptoms (DRESS) syndrome associated with the use of etravirine (Intelence®).The time to onset of DRESS syndrome is usually around 3-6 weeks and the outcome in most of the cases is favourable upon discontinuation and after initiation of corticosteroid therapy. Etravirine must be immediately discontinued if severe rash or hypersensitivity reaction is suspected, as a delay in stopping treatment after the onset of severe rash may result in a life-threatening reaction. The SPC has been revised to include information about these reactions. (Source: NeL...

Reduction in the Incidence of Squamous Cell Carcinoma in Solid Organ Transplant Recipients Treated with Cyclic Photodynamic Therapy

Dermatologic Surgery — Thu, 05 Nov 2009 00:00:00 +0100

Squamous cell carcinomas (SCCs) produce significant morbidity in solid organ transplant recipients (SOTRs), particularly in patients who develop multiple tumors. Topical photodynamic therapy (PDT) has been shown to decrease the number of keratotic lesions in SOTRs, but the duration of the beneficial effect is limited. The aim of this study was to evaluate the potential benefit of cyclic PDT in the prevention of new SCCs in SOTRs. Twelve high-risk SOTRs received cyclic PDT treatments at 4- to 8-week intervals for 2 years. The development of new SCCs (invasive and in situ) performed 12 and 24 months after the start of cyclic PDT were compared with the number of SCCs developed during the year before initiation of cyclic PDT. The median reduction in the 12- and 24-month post-treatment counts f...

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Methods for the Assessment of Skin Atrophogenicity of Topical Corticosteroids

Dermatology — Wed, 04 Nov 2009 23:00:00 +0100

Dermatologica 1976;152:117-126 (DOI:10.1159/000257872) (Source: Dermatology)

Influence of Corticosteroids on Connective Tissue

Dermatology — Wed, 04 Nov 2009 23:00:00 +0100

Dermatologica 1976;152:127-132 (DOI:10.1159/000257873) (Source: Dermatology)

Objective Measurement of Topically Applied Corticosteroids

Dermatology — Wed, 04 Nov 2009 23:00:00 +0100

Dermatologica 1976;152:133-137 (DOI:10.1159/000257874) (Source: Dermatology)

Mechanism of Local Skin Atrophy Caused by Intradermally Injected Corticosteroids

Dermatology — Wed, 04 Nov 2009 23:00:00 +0100

Dermatologica 1976;152:139-146 (DOI:10.1159/000257875) (Source: Dermatology)

Electron-Microscopic Evaluation of Collagen Fibrils after Topical Corticosteroid Therapy

Dermatology — Wed, 04 Nov 2009 23:00:00 +0100

Dermatologica 1976;152:147-153 (DOI:10.1159/000257876) (Source: Dermatology)

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Perioral Dermatitis and Rosacea-Like Dermatitis: Clinical Features and Treatment

Dermatology — Wed, 04 Nov 2009 23:00:00 +0100

Dermatologica 1976;152:155-160 (DOI:10.1159/000257877) (Source: Dermatology)

Perioral Dermatitis, an Important Side-Effect of Corticosteroids

Dermatology — Wed, 04 Nov 2009 23:00:00 +0100

Dermatologica 1976;152:161-172 (DOI:10.1159/000257887) (Source: Dermatology)

Topical Corticosteroid Therapy and Its Effect on the Hypothalamic-Pituitary-Adrenal Axis

Dermatology — Wed, 04 Nov 2009 23:00:00 +0100

Dermatologica 1976;152:173-180 (DOI:10.1159/000257888) (Source: Dermatology)

Topical and Systemic Effects of Hydrocortisone 17-Butyrate

Dermatology — Wed, 04 Nov 2009 23:00:00 +0100

Dermatologica 1976;152:181-195 (DOI:10.1159/000257889) (Source: Dermatology)

Systemic Effects and Percutaneous Absorption of Topically Applied 0.1% Hydrocortisone 17-Butyrate

Dermatology — Wed, 04 Nov 2009 23:00:00 +0100

Dermatologica 1976;152:197-207 (DOI:10.1159/000257890) (Source: Dermatology)

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Clinical Trial Comparing Hydrocortisone 17-Butyrate to Betamethasone 17-Valerate in a Series of Patients with Eczematous Skin Diseases

Dermatology — Wed, 04 Nov 2009 23:00:00 +0100

Dermatologica 1976;152:209-214 (DOI:10.1159/000257891) (Source: Dermatology)

Effect of Hydrocortisone 17-Butyrate on the Percutaneous Absorption of Antibiotics

Dermatology — Wed, 04 Nov 2009 23:00:00 +0100

Dermatologica 1976;152:215-219 (DOI:10.1159/000257892) (Source: Dermatology)

Clinical Experiences with Hydrocortisone 17-Butyrate

Dermatology — Wed, 04 Nov 2009 23:00:00 +0100

Dermatologica 1976;152:221-229 (DOI:10.1159/000257893) (Source: Dermatology)

The Treatment of Steroid-Induced Rosacea and Perioral Dermatitis

Dermatology — Wed, 04 Nov 2009 23:00:00 +0100

Dermatologica 1976;152:231-237 (DOI:10.1159/000257894) (Source: Dermatology)

Comparative Study of Triamcinolone Acetonide and Hydrocortisone 17-Butyrate in Rosacea with Special Regard to the Rebound Phenomenon

Dermatology — Wed, 04 Nov 2009 23:00:00 +0100

Dermatologica 1976;152:239-246 (DOI:10.1159/000257895) (Source: Dermatology)

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Use and Abuse of Topical Steroids

Dermatology — Wed, 04 Nov 2009 23:00:00 +0100

Dermatologica 1976;152:247-251 (DOI:10.1159/000257896) (Source: Dermatology)

General Discussion

Dermatology — Wed, 04 Nov 2009 23:00:00 +0100

Dermatologica 1976;152:253-260 (DOI:10.1159/000257897) (Source: Dermatology)

Closing Remarks

Dermatology — Wed, 04 Nov 2009 23:00:00 +0100

Dermatologica 1976;152:261-264 (DOI:10.1159/000257898) (Source: Dermatology)

Index

Dermatology — Wed, 04 Nov 2009 23:00:00 +0100

Dermatologica 1976;152:265-271 (DOI:10.1159/000257899) (Source: Dermatology)

Contributing Authors and Participants in Discussions

Dermatology — Wed, 04 Nov 2009 23:00:00 +0100

Dermatologica 1976;152:273-276 (DOI:10.1159/000257900) (Source: Dermatology)

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Original Article: Compounding dermatologic preparations in developing countries

Dermatologic Therapy — Wed, 04 Nov 2009 00:00:00 +0100

Access to medications and their proper use are essential in developing countries. An interdisciplinary team of dermatologists and pharmacists created a master list of preparations useful for treating the most common dermatologic disorders in tropical and equatorial areas. The first pilot project was done at Cardinal Leger Hospital in Leogane, Haiti. Training was given to local staff at that hospital in 2005. Four years later, the clinic continues to prepare and offer, at a reasonable price, drugs that the population needs. (Source: Dermatologic Therapy)

Original Article: Superficial cutaneous fungal infections in tropical countries

Dermatologic Therapy — Wed, 04 Nov 2009 00:00:00 +0100

Superficial fungal infections represent an important cause of morbidity for people worldwide, particularly in the tropics. Fungal infections affect the skin, hair, or the nails, and tend to thrive in the heat and humidity of tropical countries. Because of environmental and cultural factors unique to the tropics, the causative organisms and presentation of these infections may differ from those in industrialized countries. Treatment options include topical and systemic therapy. However, social and socioeconomic factors in developing tropical countries may necessitate different treatment approaches to achieve success. (Source: Dermatologic Therapy)

Imported tropical diseases

Dermatologic Therapy — Wed, 04 Nov 2009 00:00:00 +0100

are among the top three leading causes for morbidity and may affect up to 8% of returning travelers. Because the spectrum of dermatological manifestations seen in travelers is broad, it can be challenging for physicians to recognize and treat such conditions in a timely and efficient manner. Therefore, the present review highlights common imported tropical diseases with a focus on treatment regimens. Specifically, cutaneous larva migrans, myiasis, swimmer's itch, mycetoma, Chagas disease, and leishmaniasis are discussed. As awareness increases among travelers, immigrants, and health care providers regarding imported tropical diseases, early intervention and proper diagnosis can ensue, thus reducing morbidity and mortality in affected individuals. (Source: Dermatologic Therapy)

Treatment of leprosy/Hansen's disease in the early 21st century

Dermatologic Therapy — Wed, 04 Nov 2009 00:00:00 +0100

Leprosy, or Hansen's disease (HD), is caused by Mycobacterium leprae, a slowly dividing mycobacterium that has evolved to be an intracellular parasite, causing skin lesions and nerve damage. Less than 5% of people exposed to M. leprae develop clinical disease. Host cell-mediated resistance determines whether an individual will develop paucibacillary or multibacillary disease. Hansen's disease is a worldwide disease with about 150 new cases reported annually in the United States. Effective anti-mycobacterial treatments are available, and many patients experience severe reversal and erythema nodosum leprosum reactions that also require treatment. Leprosy has been the target of a World Health Organization multiple drug therapy campaign to eliminate it as a national public health problem in me...

Cutaneous ectoparasites

Dermatologic Therapy — Wed, 04 Nov 2009 00:00:00 +0100

Parasites inhabit many places in the world. Some of these can inhabit the human skin or body. Many of these have been eradicated in the developed countries but persist in some tropical environments that are fun places to visit. Visitors can bring such parasites home with them such as scabies, cutaneous larva migrans, tungiasis and myiasis. Their clinical manifestations and treatment are presented for physicians evaluating and treating travelers from exotic places. (Source: Dermatologic Therapy)

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Cutaneous and mucocutaneous leishmaniasis

Dermatologic Therapy — Wed, 04 Nov 2009 00:00:00 +0100

Leishmaniasis is a cluster of diseases caused by protozoa in the genus Leishmania. There are three basic clinical forms: cutaneous, mucocutaneous, and visceral leishmaniasis. The present review focuses on the diagnosis and treatment of cutaneous and mucocutaneous leishmaniasis. Characteristics of both the human host and the parasite species influence the clinical disease manifestations that range from asymptomatic exposure, to self-healing skin ulcers, to life-threatening widespread destructive ulcerations. Whether through medical treatment or through spontaneous resolution, skin ulcerations generally result in disfiguring scars with significant social and economic impact. Tests to confirm the diagnosis should be performed on patients who have recently visited endemic areas and have skin o...

Filariasis: diagnosis and treatment

Dermatologic Therapy — Wed, 04 Nov 2009 00:00:00 +0100

Filariasis is an infectious disease of the lymphatics and subcutaneous tissues caused by nematodes or filariae. Carried by mosquito vectors, this disease causes millions of people to suffer from lymphedema and elephantiasis, characteristics of filariasis infection. This disease can be diagnosed through the identification of microfilariae in blood or skin samples, antigen detection, radiographic imaging, or polymerase chain reaction. Mass drug administration by the World Health Organization has helped to diminish the incidence of filariasis. However, continued research on new drugs and vaccinations will be needed to control and reduce the microfilarial levels in the human population. (Source: Dermatologic Therapy)

Scabies and pyodermas – diagnosis and treatment

Dermatologic Therapy — Wed, 04 Nov 2009 00:00:00 +0100

Scabies and pyodermas are two of the commonest skin infections in tropical settings. They affect large numbers of people, particularly children, and account for a large burden of disease for peripheral health care teams. Despite this there have been significant advances in our knowledge of these diseases, their impact and their management. However there is a need to evaluate these developments in this specific setting, tropical health and in the context of communities with limited resources. This section will describe these advances and the challenges that remain. (Source: Dermatologic Therapy)

New Zealand Dermatological Society Incorporated Annual Scientific Meeting

Australasian Journal of Dermatology — Wed, 04 Nov 2009 00:00:00 +0100

(Source: Australasian Journal of Dermatology)

Erratum

Australasian Journal of Dermatology — Wed, 04 Nov 2009 00:00:00 +0100

(Source: Australasian Journal of Dermatology)

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Mervyn roy gold

Australasian Journal of Dermatology — Wed, 04 Nov 2009 00:00:00 +0100

(Source: Australasian Journal of Dermatology)

Cosmetic Dermatology: Requisites in Dermatology

Australasian Journal of Dermatology — Wed, 04 Nov 2009 00:00:00 +0100

(Source: Australasian Journal of Dermatology)

General Dermatology: Requisites in Dermatology

Australasian Journal of Dermatology — Wed, 04 Nov 2009 00:00:00 +0100

(Source: Australasian Journal of Dermatology)

Outcomes of Skin Surgery

Australasian Journal of Dermatology — Wed, 04 Nov 2009 00:00:00 +0100

(Source: Australasian Journal of Dermatology)

Dermoscopy of Hair and Scalp Disorders: With Clinical and Pathological Correlations

Australasian Journal of Dermatology — Wed, 04 Nov 2009 00:00:00 +0100

(Source: Australasian Journal of Dermatology)

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Trichilemmal cyst with homogeneous blue pigmentation on dermoscopy

Australasian Journal of Dermatology — Wed, 04 Nov 2009 00:00:00 +0100

A 61-year-old woman was referred to our dermoscopy unit for a pigmented lesion that had been present on her left arm for 8 years. The patient did not notice any enlargement or change in colour. On dermoscopy, homogeneous blue pigmentation was seen. The lesion was excised with the pre-operative diagnosis of melanoma, blue naevus and dermatofibroma. Histopathological examination showed a trichilemmal cyst in the mid-dermis. Although homogeneous blue pigmentation on dermoscopy is the hallmark of blue naevus, it may be seen in metastatic melanoma and exceptionally in hemosiderotic and cellular types of dermatofibroma. Trichilemmal cyst should be borne in mind also in the dermoscopic differential diagnosis. (Source: Australasian Journal of Dermatology)

In other journals

Australasian Journal of Dermatology — Wed, 04 Nov 2009 00:00:00 +0100

(Source: Australasian Journal of Dermatology)

Letters to the editor

Australasian Journal of Dermatology — Wed, 04 Nov 2009 00:00:00 +0100

(Source: Australasian Journal of Dermatology)

Letters to the editor

Australasian Journal of Dermatology — Wed, 04 Nov 2009 00:00:00 +0100

(Source: Australasian Journal of Dermatology)

Cutaneous malignant melanoma arising in an acquired naevus of Ota

Australasian Journal of Dermatology — Wed, 04 Nov 2009 00:00:00 +0100

We describe a 32-year-old Caucasian man with an acquired naevus of Ota with subtle pigmentation, in which a melanocytic papule developed. The lesion, deceptively, had no clinically suspicious features, but investigation revealed an aggressive cutaneous malignant melanoma, extensive orbital ring melanocytosis and metastatic brain and subsequent liver disease. (Source: Australasian Journal of Dermatology)

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Rhinophyma: Carbon dioxide laser with computerized scanner is still an outstanding treatment

Australasian Journal of Dermatology — Wed, 04 Nov 2009 00:00:00 +0100

This report demonstrates excellent cosmetic results and no major postoperative complications or recurrence of the condition after 1 year of follow up for seven patients. Two more patients had been followed up for 1 month at the time this paper was written. Scanned carbon dioxide laser is safe and highly effective treatment for rhinophyma. (Source: Australasian Journal of Dermatology)

Sézary syndrome presenting with 'leonine facies'

Australasian Journal of Dermatology — Wed, 04 Nov 2009 00:00:00 +0100

A 71-year-old man presented with erythroderma and multiple nodular skin lesions over the face, scalp, upper limbs and trunk. The facial skin was thickened, producing the rare 'leonine facies' appearance. Investigations revealed the presence of atypical lymphoid cells in the peripheral blood, bone marrow and skin. The atypical lymphoid cells in the peripheral blood and bone marrow were positive for helper T-cell antigens (CD4, CD2, CD5 and CD7) on immunophenotyping by flow cytometry. The histopathology of skin showed dermal infiltration by atypical small lymphocytes with epidermotropism. These cells were positive for helper T-lymphocyte antigens on immunohistochemistry. A diagnosis of Sézary syndrome was made based on clinical, peripheral blood and immunophenotypical findings. (Source: Aus...

Diagnosis of type I cryoglobulinaemia made through identifying crystals in the blood smear

Australasian Journal of Dermatology — Wed, 04 Nov 2009 00:00:00 +0100

We report a case of type I cryoglobulinaemia in a 52-year-old man who presented with widespread cutaneous necrosis. The diagnosis could not be established early on, as repeated testing for cryoglobulin was negative despite a careful collection method. The diagnosis was made 1 year later, on an incidental full blood smear that revealed crystals, which is an uncommon way to diagnose this condition. We discuss the difficulties we faced in establishing the diagnosis and emphasise the need for repeat cryoglobulin testing in this clinical setting. In such cases, examination of a blood smear should be considered. (Source: Australasian Journal of Dermatology)

Chronic localized intravascular coagulation complicating multifocal venous malformations

Australasian Journal of Dermatology — Wed, 04 Nov 2009 00:00:00 +0100

We present two female children aged 7 years with extensive multifocal venous malformations complicated by chronic localized intravascular coagulation. In both cases ultrasonography and magnetic resonance imaging revealed extensive venous malformations involving the skin, mucous membranes and pharynx, which were not apparent on clinical examination. Haematological investigations demonstrated persistent elevation of the D-dimer, consistent with chronic localized intravascular coagulation. The course of one patient was complicated by the development of multiple painful thromboses at distant sites following percutaneous sclerotherapy. Persistent elevation of the D-dimer occurring in association with large venous and veno-lymphatic malformations has been termed chronic localized intravascular c...

Childhood ocular rosacea: Considerations for diagnosis and treatment

Australasian Journal of Dermatology — Wed, 04 Nov 2009 00:00:00 +0100

We report three cases of paediatric ocular rosacea responding to prolonged treatment with oral erythromycin. Our cases demonstrate the close association of periorificial dermatitis with childhood rosacea, and highlight the importance of eye signs in its diagnostic criteria. (Source: Australasian Journal of Dermatology)

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Topical diphencyprone immunotherapy for cutaneous metastatic melanoma

Australasian Journal of Dermatology — Wed, 04 Nov 2009 00:00:00 +0100

Topical immunotherapy with contact sensitizers for metastatic melanoma was first reported more than 30 years ago. Diphencyprone (DPCP) immunotherapy is frequently used to treat cutaneous warts and alopecia areata, and we have previously reported the use of DPCP as a single agent to successfully treat extensive, radiotherapy-resistant melanoma metastases on the scalp. We now report DPCP treatment of a further six patients with cutaneous metastatic melanoma. Of seven patients treated with DPCP thus far, four have demonstrated complete responses of their cutaneous lesions and three have had partial responses. The treatment was well-tolerated by all patients. Topical immunotherapy with DPCP is inexpensive and relatively non-invasive and should be considered in patients with locally advanced sk...

Cutaneous invasive squamous cell carcinoma: 10-year experience and recommendations for follow up

Australasian Journal of Dermatology — Wed, 04 Nov 2009 00:00:00 +0100

Currently, the National Health and Medical Research Council do not have any recommendations about the frequency of follow up after treatment of primary cutaneous invasive squamous cell cancer (SCC), due to a lack of data. The present study aimed to establish appropriate follow-up times and to determine the long-term risk of subsequent non-melanoma skin cancers and melanoma. Patients who had a primary invasive cutaneous SCC excised during 1996 were retrospectively identified from the databases of a dermatologist in private practice in south-east Queensland. Data on size, site, depth, differentiation, perineural involvement, lymphovascular involvement of the index SCC were obtained. The patients were regularly followed up and lymph-node involvement, patient immunocompetence, and the presence...

Melanoma in private practice: Do dermatologists make a difference?

Australasian Journal of Dermatology — Wed, 04 Nov 2009 00:00:00 +0100

Malignant melanoma is a major contributor to Australian morbidity and mortality. In this era of resource rationalisation, we seek to address the issue of whether routine full-skin examination by a dermatologist, rather than focussed examination of flagged lesions, will increase melanoma diagnosis. A retrospective chart review was undertaken between 1 July 2007 and 30 June 2008 in a private dermatology group practice in order to ascertain the number and characteristics of incidentally detected melanomas on routine skin examination. A total of 94 melanomas were detected during this 12-month period. Of these, 57 (60.6%) were incidentally detected by the dermatologist, 41 (71.9%) were in situ melanomas and 16 (28.1%) were invasive melanoma. Of the invasive lesions, 15 (94%) were 'thin' (less t...

Role of definitive radiotherapy in treating patients with inoperable Merkel cell carcinoma: The Westmead Hospital experience and a review of the literature

Australasian Journal of Dermatology — Wed, 04 Nov 2009 00:00:00 +0100

We report the results of eight patients with inoperable MCC treated with RTx alone between 1993 and 2007 at Westmead Hospital, Sydney, Australia, and also review the relevant literature on definitive RTx in the treatment of MCC. The median age at diagnosis was 82.5 years in five women and three men. All patients were Caucasian and none were immunosuppressed. Seven of eight patients were clinically node-positive. The mean duration of follow up was 12 months. A median dose of 50 Gy was prescribed. Seven of eight patients with inoperable MCC achieved in-field control, with most eventually relapsing distantly. Treatment-related toxicity was acceptable. In keeping with our results, other studies also report high rates of in-field locoregional control following RTx alone. These findings highligh...

Paediatric vulval lichen sclerosus

Australasian Journal of Dermatology — Wed, 04 Nov 2009 00:00:00 +0100

Lichen sclerosus (LS) in children is uncommon; however, it is an important differential diagnosis in any pre-pubertal child presenting with chronic vulval symptoms. The long-term prognosis is unknown; however, recent data suggests that the assumption that the condition will resolve at puberty may be incorrect. Children with LS require long-term management with topical corticosteroids, which remains the treatment of choice, as well as long-term follow up. We review the current literature on paediatric vulval LS. (Source: Australasian Journal of Dermatology)

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Select the most correct answers – multiple answers possible for questions 1–11

Australasian Journal of Dermatology — Wed, 04 Nov 2009 00:00:00 +0100

(Source: Australasian Journal of Dermatology)

Clinical Outcome of Cutaneous Flaps Versus Full-Thickness Skin Grafts After Mohs Surgery on the Nose

Dermatologic Surgery — Wed, 04 Nov 2009 00:00:00 +0100

In this study, 43 flaps and 24 grafts were evaluated using a modified Hollander Wound Evaluation Scale and a visual analogue scale. The mean visual analogue scale score was significantly better for flap repairs than for graft repairs. In addition, 100% of flaps had an acceptable overall cosmetic appearance on the basis of the Hollander Wound Evaluation Scale, compared with only 75% of skin grafts. For defects on the nose where flap and graft repair may both be technically possible, a flap may be more likely to result in superior cosmetic outcome. The authors have indicated no significant interest with commercial supporters. (Source: Dermatologic Surgery)

Morphologic Study of Normal, Ingrown, and Pincer Nails

Dermatologic Surgery — Wed, 04 Nov 2009 00:00:00 +0100

The objectives were to analyze the circumferential length of pincer nail and the relationship between nail deformity and the underlying distal phalangeal shape. The circumferential length of 53 pincer nails was determined at successive 5-mm intervals of the nail plate. Sixty great toes, including normal (n=20), ingrown (n=20), and pincer nails (n=20), were assessed with respect to body height, body weight, body mass index, nail height, nail width index, and nail height index. Nail angle and height of osteophyte were measured. Despite the presence or absence of overcurvature, the circumferential length displayed nearly identical values across the proximal to distal range of the nail. In the pincer nail group, only the correlation between the width and height indices was statistically signif...

Use of Latex-Free Elastic Bandage to Simulate Flap Mechanics

Dermatologic Surgery — Wed, 04 Nov 2009 00:00:00 +0100

The authors have indicated no significant interest with commercial supporters. (Source: Dermatologic Surgery)

"Halo" Grafting—A Simple and Effective Technique of Skin Grafting

Dermatologic Surgery — Wed, 04 Nov 2009 00:00:00 +0100

Sharad P. Paul, MD, M Phil, has indicated no significant interest with commercial supporters (Source: Dermatologic Surgery)

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Reconstruction of the Anterior Cheek, Upper Nasal Ala, and Lateral Nasal Sidewall

Dermatologic Surgery — Wed, 04 Nov 2009 00:00:00 +0100

The author has indicated no significant interest with commercial supporters. (Source: Dermatologic Surgery)

Pulmonary Metastasis from a Giant Polypoid Basal Cell Carcinoma in the Lumbosacral Area

Dermatologic Surgery — Wed, 04 Nov 2009 00:00:00 +0100

The authors have indicated no significant interest with commercial supporters. (Source: Dermatologic Surgery)

Nonmelanoma Skin Cancer with Perineural Invasion: Report of Outcomes of a Case Series

Dermatologic Surgery — Wed, 04 Nov 2009 00:00:00 +0100

The authors have indicated no significant interest with commercial supporters (Source: Dermatologic Surgery)

Total Excision of Acquired Periungual Fibrokeratoma Using Bilateral Proximal Nail Fold Oblique Incision for Preserving Nail Matrix

Dermatologic Surgery — Wed, 04 Nov 2009 00:00:00 +0100

The authors have indicated no significant interest with commercial supporters. (Source: Dermatologic Surgery)

Severe Urticaria After Laser Treatment for Hair Reduction

Dermatologic Surgery — Wed, 04 Nov 2009 00:00:00 +0100

The author has indicated no significant interest with commercial supporters. (Source: Dermatologic Surgery)

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Dermoscopic Features of Pigmentation in Laugier-Hunziker-Baran Syndrome

Dermatologic Surgery — Wed, 04 Nov 2009 00:00:00 +0100

The authors have indicated no significant interest with commercial supporters. (Source: Dermatologic Surgery)

Delayed Nicolau's Livedoid Dermatitis after Ultrasound-Guided Sclerotherapy

Dermatologic Surgery — Wed, 04 Nov 2009 00:00:00 +0100

The authors have indicated no significant interest with commercial supporters. (Source: Dermatologic Surgery)

Long-term results after reconstruction of full thickness scalp defects with a dermal regeneration template

Journal of the European Academy of Dermatology and Venereology — Wed, 04 Nov 2009 00:00:00 +0100

Conclusion After reconstruction of full thickness scalp defects with Integra®, the cosmetic results are appealing and we observed no local recurrences during the follow-up period. (Source: Journal of the European Academy of Dermatology and Venereology)

Drying stress and damage processes in human stratum corneum

International Journal of Cosmetic Science — Wed, 04 Nov 2009 00:00:00 +0100

We describe the application of a substrate curvature technique adapted for biological tissue to accurately characterize SC drying stresses as a function of time following environmental pre-conditioning and chemical treatment in a range of drying environments. SC stresses were observed to increase to stress levels of up to [sim] 3 MPa over periods of 8 h depending on pretreatment and drying environment. A unique relationship between the SC stress and water in the drying environment was established. The effect of glycerol on lowering SC stresses and damaging surfactants on elevating SC stresses were quantified. Extensions of the method to continuous monitoring of SC stresses in response to changes in environmental moisture content and temperature are reported. Finally, a biomechanics framewo...

Academic Productivity and Affiliation of Dermatologic Surgeons

Dermatologic Surgery — Wed, 04 Nov 2009 00:00:00 +0100

Because Mohs fellowship training typically incorporates a research component, as required by the Mohs College for fellowship certification, we evaluated whether Mohs microscopic surgery fellowship-trained (MMSFT) dermatologic surgeons were more likely to join academic institutions and demonstrate greater activity in teaching, research, and scientific writing than non-fellowship-trained surgeons (NMMSFT). Responses to the 2002 and 2005 American Academy of Dermatology Practice Profile survey comparing practice settings, proportion of time spent in various practice settings, and professional roles were compared between the two groups. MMSFT dermatologic surgeons were 5 times as likely to be in full-time academic practice and 3 times as likely to be in part-time academia as NMMSFT dermatologic...

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Treatment of benign digit tip tumours by surgical excision and secondary intention healing with scar quality assessment by epidermal ridge patterns

British Journal of Dermatology — Wed, 04 Nov 2009 00:00:00 +0100

(Source: British Journal of Dermatology)

Buchbesprechungen

Dermatology — Tue, 03 Nov 2009 23:00:00 +0100

Dermatologische Zeitschrift 1931;61:294-295 (DOI:10.1159/000257643) (Source: Dermatology)

Zur 25 jährigen Wiederkehr des Todestages von Fritz Schaudinn

Dermatology — Tue, 03 Nov 2009 23:00:00 +0100

Dermatologische Zeitschrift 1931;61:296-297 (DOI:10.1159/000257644) (Source: Dermatology)

Personalien und Tagesnachrichten

Dermatology — Tue, 03 Nov 2009 23:00:00 +0100

Dermatologische Zeitschrift 1931;61:297-298 (DOI:10.1159/000257645) (Source: Dermatology)

Contents, Vol. 61, 1931

Dermatology — Tue, 03 Nov 2009 23:00:00 +0100

Dermatologische Zeitschrift 1931;61:I (DOI:10.1159/000257646) (Source: Dermatology)

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I. Multiple Hautgangrän bei Periarteriitis nodosa. Ein Beitrag zur Kenntnis der multiplen neurotischen Hautgangrän und der Hautveränderungen bei Periarteriitis nodosa

Dermatology — Tue, 03 Nov 2009 23:00:00 +0100

Dermatologische Zeitschrift 1931;61:299-320 (DOI:10.1159/000257647) (Source: Dermatology)

II. Folliculitis sycosiformis atrophicans corporis

Dermatology — Tue, 03 Nov 2009 23:00:00 +0100

Dermatologische Zeitschrift 1931;61:321-360 (DOI:10.1159/000257648) (Source: Dermatology)

III. Multiples benignes Sarkoid bei einem Säugling

Dermatology — Tue, 03 Nov 2009 23:00:00 +0100

Dermatologische Zeitschrift 1931;61:360-365 (DOI:10.1159/000257649) (Source: Dermatology)

IV. Über tertiäre Syphilis

Dermatology — Tue, 03 Nov 2009 23:00:00 +0100

Dermatologische Zeitschrift 1931;61:365-371 (DOI:10.1159/000257650) (Source: Dermatology)

V. Bemerkungen über psoriasiforme Salvarsan -- (Syntharsan) Exantheme und Beeinflussung der morphologischen Gestaltung der Psoriasis bei einem Luetiker durch spezifische Therapie

Dermatology — Tue, 03 Nov 2009 23:00:00 +0100

Dermatologische Zeitschrift 1931;61:372-383 (DOI:10.1159/000257651) (Source: Dermatology)

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VI. Über den Einflub von Hunger und Flüssigkeitseinschränkungen auf die K-, Ca-, Cl- und Wasserverschiebungen in der bestrahlten Kaninchenhaut

Dermatology — Tue, 03 Nov 2009 23:00:00 +0100

Dermatologische Zeitschrift 1931;61:384-389 (DOI:10.1159/000257652) (Source: Dermatology)

VII. Über einen Fall von Dermatoneuromyositis

Dermatology — Tue, 03 Nov 2009 23:00:00 +0100

Dermatologische Zeitschrift 1931;61:390-395 (DOI:10.1159/000257653) (Source: Dermatology)

VIII. Experimentelle Untersuchungen über Lymphogranuloma inguinale (L. i.)

Dermatology — Tue, 03 Nov 2009 23:00:00 +0100

Dermatologische Zeitschrift 1931;61:395-399 (DOI:10.1159/000257654) (Source: Dermatology)

IX. Serologische Untersuchungen bei gesunden und syphilitischen Kaninchen

Dermatology — Tue, 03 Nov 2009 23:00:00 +0100

Dermatologische Zeitschrift 1931;61:400-405 (DOI:10.1159/000257655) (Source: Dermatology)

Berliner Dermatologische Gesellschaft

Dermatology — Tue, 03 Nov 2009 23:00:00 +0100

Dermatologische Zeitschrift 1931;61:405-419 (DOI:10.1159/000257656) (Source: Dermatology)

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Periodische Literatur

Dermatology — Tue, 03 Nov 2009 23:00:00 +0100

Dermatologische Zeitschrift 1931;61:420-436 (DOI:10.1159/000257657) (Source: Dermatology)

Buchbesprechungen

Dermatology — Tue, 03 Nov 2009 23:00:00 +0100

Dermatologische Zeitschrift 1931;61:437-438 (DOI:10.1159/000257658) (Source: Dermatology)

Gedenkfeier zur 25 jährigen Wiederkehr des Todestages von Fritz Schaudinn im Zoologischen Institut der Universität Berlin

Dermatology — Tue, 03 Nov 2009 23:00:00 +0100

Dermatologische Zeitschrift 1931;61:438-439 (DOI:10.1159/000257659) (Source: Dermatology)

Personalien und Tagesnachrichten

Dermatology — Tue, 03 Nov 2009 23:00:00 +0100

Dermatologische Zeitschrift 1931;61:440 (DOI:10.1159/000257660) (Source: Dermatology)

Sachregister

Dermatology — Tue, 03 Nov 2009 23:00:00 +0100

Dermatologische Zeitschrift 1931;61:441-449 (DOI:10.1159/000257661) (Source: Dermatology)

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Namenregister

Dermatology — Tue, 03 Nov 2009 23:00:00 +0100

Dermatologische Zeitschrift 1931;61:449-452 (DOI:10.1159/000257662) (Source: Dermatology)

Switch to 'Light' Cigarettes Makes Quitting Tougher

MedicineNet Skin General — Tue, 03 Nov 2009 07:00:00 +0100

Title: Switch to 'Light' Cigarettes Makes Quitting TougherCategory: Health NewsCreated: 11/3/2009 8:10:00 AMLast Editorial Review: 11/3/2009 (Source: MedicineNet Skin General)

Health Tip: Have a Food Allergy?

MedicineNet Skin General — Tue, 03 Nov 2009 07:00:00 +0100

Title: Health Tip: Have a Food Allergy?Category: Health NewsCreated: 11/3/2009 8:10:00 AMLast Editorial Review: 11/3/2009 (Source: MedicineNet Skin General)

Radiation After Surgery Lowers Chances of Melanoma Recurrence

MedicineNet Skin General — Tue, 03 Nov 2009 07:00:00 +0100

Title: Radiation After Surgery Lowers Chances of Melanoma RecurrenceCategory: Health NewsCreated: 11/2/2009 2:10:00 PMLast Editorial Review: 11/3/2009 (Source: MedicineNet Skin General)

Cutaneous tuberculosis revealed by infliximab therapy for presumed sarcoidosis

Clinical And Experimental Dermatology — Tue, 03 Nov 2009 00:00:00 +0100

(Source: Clinical And Experimental Dermatology)

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Systemic vasculitis developing after hydroxychloroquine interruption in a patient with Sjögren's syndrome

Clinical And Experimental Dermatology — Tue, 03 Nov 2009 00:00:00 +0100

(Source: Clinical And Experimental Dermatology)

Rhinoentomophthoromycosis with mutilation

Clinical And Experimental Dermatology — Tue, 03 Nov 2009 00:00:00 +0100

We report a case of rhinoentomophthoromycosis with mutilation, which is an even more unusual phenomenon, and discuss the clinical features and management of this rare dermatosis. (Source: Clinical And Experimental Dermatology)

Beau's lines after octreotide therapy

Clinical And Experimental Dermatology — Tue, 03 Nov 2009 00:00:00 +0100

(Source: Clinical And Experimental Dermatology)

Does collapse of immune privilege in the hair-follicle bulge play a role in the pathogenesis of primary cicatricial alopecia?

Clinical And Experimental Dermatology — Tue, 03 Nov 2009 00:00:00 +0100

Conclusions. This small series represents our first preliminary attempts to ascertain whether bulge IP collapse may play a role in PCA pathogenesis. We present standard parameters relating to hair-follicle IP in the bulge region of three patients with distinct PCA variants, and show the presence of features consistent with bulge IP collapse in each case. (Source: Clinical And Experimental Dermatology)

Photodynamic therapy with methyl 5-aminolevulinate acid combined with microneedle treatment in patients with extensive alopecia areata

Clinical And Experimental Dermatology — Tue, 03 Nov 2009 00:00:00 +0100

(Source: Clinical And Experimental Dermatology)

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Stimulation of epidermal calcium gradient loss increases the expression of hyaluronan and CD44 in mouse skin

Clinical And Experimental Dermatology — Tue, 03 Nov 2009 00:00:00 +0100

Conclusions. These results suggest that modulations in epidermal calcium regulate HA and CD44 expression directly or via induction of cytokines. (Source: Clinical And Experimental Dermatology)

Phototherapy of generalized prurigo nodularis

Clinical And Experimental Dermatology — Tue, 03 Nov 2009 00:00:00 +0100

(Source: Clinical And Experimental Dermatology)

Reticular variant of mid-dermal elastolysis after insertion of a pacemaker

Clinical And Experimental Dermatology — Tue, 03 Nov 2009 00:00:00 +0100

We report a case of reticular erythema with mid-dermal elastolysis that occurred in a 70-year-old man after insertion of a pacemaker. (Source: Clinical And Experimental Dermatology)

Diffuse (anergic) cutaneous leishmaniasis responding to amphotericin B

Clinical And Experimental Dermatology — Tue, 03 Nov 2009 00:00:00 +0100

We report on a severe an exceptional case that resolved after treatment with amphotericin B, a drug considered only mildly effective, and discuss the therapeutic approach to this disease. (Source: Clinical And Experimental Dermatology)

Reticulohistiocytosis: different dermatoscopic faces and a good response to methotrexate treatment

Clinical And Experimental Dermatology — Tue, 03 Nov 2009 00:00:00 +0100

We report a case of diffuse cutaneous reticulohistiocytosis with 29 reticulohistiocytomas. On dermatoscopy of these lesions, we saw three typical features: a homogeneous pattern with various shades of yellow (defined previously as a 'setting-sun' pattern), brown reticular structures, and central white scar-like patches and streaks. The setting-sun pattern was most commonly seen in combination with brown reticular structures. In four lesions, brown reticular structures surrounded a central white scar-like patch resembling that of a dermatofibroma. However, the presence of the setting-sun pattern in the background gave a different hue to that of the peripheral network seen in a dermatofibroma. A marked clinical improvement was associated with 6 months of systemic methotrexate treatment. Derm...

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Disseminated strongyloidiasis caused by heart donor-to-host transmission presenting with purpura

Clinical And Experimental Dermatology — Tue, 03 Nov 2009 00:00:00 +0100

(Source: Clinical And Experimental Dermatology)

Health behaviour models: a framework for studying adherence in children with atopic dermatitis

Clinical And Experimental Dermatology — Tue, 03 Nov 2009 00:00:00 +0100

Atopic dermatitis (AD) is a common problem of childhood causing considerable distress. Effective topical treatments exist, yet poor adherence often results in poor outcomes. A framework is needed to better understand adherence behaviour. To provide a basis for this framework, we reviewed established models used to describe health behaviour. Structural elements of these models informed the development of an adherence model for AD that can be used to complement empirical AD treatment trials. Health behaviour models provide a means to describe factors that affect adherence and that can mediate the effects of different adherence interventions. Models of adherence behaviour are important for promoting better treatment outcomes for children with AD and their families. These models provide a mean...

Familial coincidence of hidradenitis suppurativa and steatocystoma multiplex

Clinical And Experimental Dermatology — Tue, 03 Nov 2009 00:00:00 +0100

(Source: Clinical And Experimental Dermatology)

Cutaneous leishmaniasis treated with itraconazole

Dermatologic Therapy — Tue, 03 Nov 2009 00:00:00 +0100

We report a case of cutaneous Leishmaniasis in a young girl successfully treated with itraconazole. (Source: Dermatologic Therapy)

An overview of delayed pressure urticaria with special emphasis on pathogenesis and treatment

Dermatologic Therapy — Tue, 03 Nov 2009 00:00:00 +0100

Delayed pressure urticaria (DPU) is a physical urticaria characterized by the development of deep swellings at sites of pressure application on the skin. Etiopathogenesis of DPU is still unknown, although the available evidence suggests the involvement of mast cells through non-immunologic mechanisms and the role of several mediators beyond histamine, such as proinflammatory cytokines. The management of DPU is complex, also considering that prevention is very difficult and DPU frequently coexists with chronic "idiopathic" urticaria. Moreover, H1-antihistamines, which are the mainstay of treatment for common urticaria, usually provide less satisfactory results as compared with other urticarias. Therefore, numerous treatment alternatives have been proposed for severe refractory cases, such a...

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Ultrasound evaluation of clobetasol propionate 0.05% foam application in psoriatic and healthy skin: a pilot study

Dermatologic Therapy — Tue, 03 Nov 2009 00:00:00 +0100

The aim of the present study was to evaluate through ultrasound imaging the response to treatment of twice and once daily application of clobetasol propionate 0.05% foam on psoriatic skin as well as the atrophogenic potential of once daily application of the foam on healthy skin. The study included a total of 40 participants, 30 affected by Psoriasis vulgaris and 10 healthy volunteers. Patients with psoriasis were branched in two groups of 15 subjects: in the first group, clobetasol propionate 0.05% foam was applied twice daily for up to 2 weeks on targeted plaques, in the second group, it was applied once daily for up to 4 weeks. Ten healthy adult volunteers were instructed to apply the foam to a 4 × 4 cm area on the volar aspect of the forearm once daily for 4 weeks. Ultrasound evaluati...

Treatment of erythrodermic psoriasis in HCV+ patient with adalimumab

Dermatologic Therapy — Tue, 03 Nov 2009 00:00:00 +0100

Erythrodermic psoriasis is a severe and disabling variant of psoriasis. The authors present the case of a 48-year-old man with psoriasis and hemophilia presented with a history of hepatitis C virus (HCV) infection treated with pegylated interferon alpha-2a and ribavirin therapy. At the end of antiviral therapy, skin manifestation progressively worsened, becoming erythrodermic, with lack of efficacy of steroid therapy. The authors decided to start biological therapy with induction dose of adalimumab (Humira, Abbott Laboratories, Abbott Park, Chicago, IL) 80 mg at Week 0 and 40 mg weekly. In our case, this resulted in a highly effective and safe treatment. (Source: Dermatologic Therapy)

Fractional CO2 laser: a novel therapeutic device upon photobiomodulation of tissue remodeling and cytokine pathway of tissue repair

Dermatologic Therapy — Tue, 03 Nov 2009 00:00:00 +0100

Minimally ablative fractional laser devices have gained acceptance as a preferred method for skin resurfacing. Notable improvements in facial rhytides, photodamage, acne scarring, and skin laxity have been reported. The aim of the present work was to compare how different CO2 laser fluences, by modulating the secretory pathway of cytokines, are able to influence the wound-healing process, and how these fluences are associated with different clinical results. Eighteen patients, all with photodamaged skin, were treated using a fractional CO2 laser (SmartXide DOT, Deka M.E.L.A., Florence, Italy) with varying laser fluences (2.07, 2.77, and 4.15 J/cm2). An immunocytochemical study was performed at defined end points in order to obtain information about specific cytokines of the microenvironmen...

Visible skin condition and perception of human facial appearance

International Journal of Cosmetic Science — Tue, 03 Nov 2009 00:00:00 +0100

This article (i) reviews briefly some of the main determinants of visible skin condition, (ii) presents recent evidence on its signalling value in face perception and (iii) suggests areas for future research with reference to an evolutionary psychology framework. La psychologie évolutive suggère que certaines normes de beauté de l'homme ont évolué pour fournir des indices fiables de la fécondité et la santé. Par conséquent, les préférences pour certaines caractéristiques physiques du visage et du corps sont censées refléter les adaptations pour la promotion de ce choix. Les études portant sur l'attractivité du visage se sont essentiellement concentrées sur des fonctionnalités telles que la symétrie, l'aspect d'ensemble et le sexe, éléments typiques développés dans le...

Lipopeptides in cosmetics

International Journal of Cosmetic Science — Tue, 03 Nov 2009 00:00:00 +0100

Lipopeptides are biosurfactants extensively used in cosmetics. The consumption of cosmetics containing lipopeptides is increasing as a result of the exceptional surface properties and diverse biological activities of lipopeptides which facilitate a vast number of applications not only in the pharmaceutics industry which includes cosmetics but also in the food industry. Cosmetics containing lipopeptides are available in various dosage forms according to their beneficial surface properties, which include anti-wrinkle and moisturizing activities and cleansing cosmetics. The microbial production of lipopeptides particularly those with biological and surface activities applicable to cosmetics are summarized based on appropriate studies and patents up to the year 2008 to manage the information a...

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Biophysic evaluation of polysaccharide gel from durian's fruit hulls for skin moisturizer

International Journal of Cosmetic Science — Tue, 03 Nov 2009 00:00:00 +0100

Durian or Dutio zibethinus Murr. (Bombacaceae) is a tropical fruit native to Southeast Asia particularly cultivated in Thailand as an economic plant. Once it is consumed, the fruit hulls are discarded as waste products. Polysaccharide gel (PG) from durian's fruit hulls is obviously efficient for use in the preparations of food and pharmaceutical products. This research focused on biophysical assessment of PG durian's fruit hulls for cosmetic formulation. The efficacy of facial skin capacitance and firmness increment of PG formulation were evaluated. Its application showed significant effect on skin capacitance after 28 and 56 days (P = 0.024 and P = 0.003) and significantly increased skin firmness after 56 days of treatment (P = 0.017) with non-allergic effect as there were no positive pat...

Simple and rapid analytical method for the simultaneous determination of cetrimonium chloride and alkyl alcohols in hair conditioners

International Journal of Cosmetic Science — Tue, 03 Nov 2009 00:00:00 +0100

A simple method for the simultaneous determination of a cationic surfactant (cetrimonium chloride) and four non-ionic surfactants (1-tetradecanol, 1-hexadecanol, 1-octadecanol and 1-eicosanol) has been developed. Direct extraction of the analytes from the sample with methanol and a subsequent separation using reversed-phase high-performance liquid chromatography with refractive index detection are the steps followed in the procedure. The column used was a Luna C18 and the mobile phase consisted of a 0.1 M KClO4 solution prepared on a 95:5 mixture of methanol and water. This solution was adjusted to pH 2.8 with phosphoric acid. Recoveries close to 100% were obtained in spiked commercial hair conditioner samples for the surfactants assayed using this method. Limits of detection were 10.4, 16...

Skin Tightening Effect Using Fractional Laser Treatment: I. A Randomized Half-Side Pilot Study on Faces of Patients with Acne

Dermatologic Surgery — Tue, 03 Nov 2009 00:00:00 +0100

Fractional laser resurfacing is a new procedure for skin rejuvenation. To assess the skin remodeling effect of fractional laser treatment. Twelve Asian patients with acne were irradiated using a fractional 1,540-nm erbium glass laser on a random half of the face twice with a 4-week interval. The faces were contoured on the treated side of most patients. Statistical analyses of the facial images showed that the skin tightening effect was significant 4 weeks after the first and second irradiation (p (Source: Dermatologic Surgery)

Diameter of Involved Nerves Predicts Outcomes in Cutaneous Squamous Cell Carcinoma with Perineural Invasion: An Investigator-Blinded Retrospective Cohort Study

Dermatologic Surgery — Tue, 03 Nov 2009 00:00:00 +0100

Perineural invasion (PNI) has been associated with poor prognosis in cutaneous squamous cell carcinoma (CSCC), but it is unclear how different degrees of nerve involvement affect prognosis. To determine whether the diameter of nerves invaded by CSCC affects outcomes of recurrence, metastasis, and disease-specific and overall survival. A retrospective cohort study was conducted of patients with CSCC with PNI. Dermatopathologists blinded to subject outcomes determined the diameter of the largest involved nerve. Data were obtainable for 48 patients. Small-caliber nerve invasion (SCNI) of nerves less than 0.1 mm in diameter was associated with significantly lower risks of all outcomes of interest. Disease-specific death was 0% in subjects with SCNI, versus 32% in those with large-caliber nerve...

MedWorm: Dermatology

Psoriasis not independently linked to ischemic heart disease

Psoriasis not independently linked to ischemic heart disease

Novexel Starts Phase II Clinical Trial With NXL103 In Adults With Acute Bacterial Skin And Skin Structure Infections (ABSSSI)

Theravance And Astellas Announce The Commercial Launch Of VIBATIVTM (telavancin) In The United States

Lichen Planus and dyslipidaemia: a Case–control Study

Post surgical radiotherapy lowers lymph node recurrence in melanoma patients

Gestational diabetes increases risk for infant atopic dermatitis

Essentials of dermatology - for all sections of medical fraternity-D M Thappa

Sanitary pad dermatitis

Simultaneous co-occurrence of porokeratosis of mibelli with disseminated superficial actinic porokeratosis

Idiopathic calcinosis cutis

Malignant melanoma with a seborrheic keratosis-like clinical presentation

Species identification of <i>Candida</i> isolates obtained from oral lesions of HIV infected patients

Cutaneous zygomycosis due to <i>Saksenaea vasiformis</i> in an immunocompetent host

Recurrent ovarian malignancy presenting as cutaneous metastasis

Hyper IgE syndrome with umbilical hernia

Cutis marmorata telangiectatica congenita with skin ulcerations in a new born

Rare association of hyper IgE syndrome with cervical rib and natal teeth

Diffuse plane xanthomatosis in a patient with <i>Budd-Chiari syndrome</i> and monoclonal gammopathy

Comparative evaluation of long pulse alexandrite laser and intense pulsed light systems for pseudofolliculitis barbae treatment with one year of follow up

Treatment of periocular hyperpigmentation due to lead of kohl (surma) by penicillamine: A single group non-randomized clinical trial

Vitiligo treatment with vitamins, minerals and polyphenol supplementation

Efficacy and tolerability of cefditoren pivoxil in uncomplicated skin and skin structure infections in Indian patients

Pattern of sexually transmitted<b><i> </b></i>infections in a tertiary care centre at Puducherry

Recurrence pattern in squamous cell carcinoma of skin of lower extremities and abdominal wall (Kangri cancer) in Kashmir valley of Indian subcontinent: Impact of various treatment modalities

Dermatological manifestations in HIV-infected patients at a tertiary care hospital in a tribal (Bastar) region of Chhattisgarh, India

Familial reactive perforating collagenosis

Dermatology life quality index scores in vitiligo: Reliability and validity of the Tunisian version

Photo-stimulatory effect of low energy helium-neon laser irradiation on excisional diabetic wound healing dynamics in wistar rats

Quantitation of mast cells and collagen fibers in skin tags

Vitiligo and the melanocyte reservoir

Chronic urticaria and treatment options

Topical treatment of melasma

Cellulitis

Janssen issues letter about reports of toxic epidermal necrolysis and DRESS syndrome associated with etravirine (Intelence®)

Reduction in the Incidence of Squamous Cell Carcinoma in Solid Organ Transplant Recipients Treated with Cyclic Photodynamic Therapy

Methods for the Assessment of Skin Atrophogenicity of Topical Corticosteroids

Influence of Corticosteroids on Connective Tissue

Objective Measurement of Topically Applied Corticosteroids

Mechanism of Local Skin Atrophy Caused by Intradermally Injected Corticosteroids

Electron-Microscopic Evaluation of Collagen Fibrils after Topical Corticosteroid Therapy

Perioral Dermatitis and Rosacea-Like Dermatitis: Clinical Features and Treatment

Perioral Dermatitis, an Important Side-Effect of Corticosteroids

Topical Corticosteroid Therapy and Its Effect on the Hypothalamic-Pituitary-Adrenal Axis

Topical and Systemic Effects of Hydrocortisone 17-Butyrate

Systemic Effects and Percutaneous Absorption of Topically Applied 0.1% Hydrocortisone 17-Butyrate

Clinical Trial Comparing Hydrocortisone 17-Butyrate to Betamethasone 17-Valerate in a Series of Patients with Eczematous Skin Diseases

Effect of Hydrocortisone 17-Butyrate on the Percutaneous Absorption of Antibiotics

Clinical Experiences with Hydrocortisone 17-Butyrate

The Treatment of Steroid-Induced Rosacea and Perioral Dermatitis

Comparative Study of Triamcinolone Acetonide and Hydrocortisone 17-Butyrate in Rosacea with Special Regard to the Rebound Phenomenon

Use and Abuse of Topical Steroids

General Discussion

Closing Remarks

Index

Contributing Authors and Participants in Discussions

Original Article: Compounding dermatologic preparations in developing countries

Original Article: Superficial cutaneous fungal infections in tropical countries

Imported tropical diseases

Treatment of leprosy/Hansen's disease in the early 21st century

Cutaneous ectoparasites

Cutaneous and mucocutaneous leishmaniasis

Filariasis: diagnosis and treatment

Scabies and pyodermas – diagnosis and treatment

New Zealand Dermatological Society Incorporated Annual Scientific Meeting

Erratum

Mervyn roy gold

Cosmetic Dermatology: Requisites in Dermatology

General Dermatology: Requisites in Dermatology

Outcomes of Skin Surgery

Dermoscopy of Hair and Scalp Disorders: With Clinical and Pathological Correlations

Trichilemmal cyst with homogeneous blue pigmentation on dermoscopy

In other journals

Letters to the editor

Letters to the editor

Cutaneous malignant melanoma arising in an acquired naevus of Ota

Rhinophyma: Carbon dioxide laser with computerized scanner is still an outstanding treatment

Sézary syndrome presenting with 'leonine facies'

Diagnosis of type I cryoglobulinaemia made through identifying crystals in the blood smear