MedWorm: Dermatology

Announcements

Journal of Dermatological Science — Tue, 16 Mar 2010 14:28:25 +0100

(Source: Journal of Dermatological Science)

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Six novel ATP2C1 mutations identified in Chinese patients with Hailey–Hailey disease

Journal of Dermatological Science — Tue, 16 Mar 2010 14:28:25 +0100

Hailey–Hailey disease (HHD) (OMIM 169600), also known as familial benign chronic pemphigus, is a rare autosomal dominantly inherited dermatosis. It is characterized by suprabasal separation (acantholysis) of the epidermis resulting in recurrent blisters, crusted erosions, and warty papules that occur mainly on the body folds, particularly the groin, axillary region, the neck, perianal, and submammary region. Painful erosions in the intertriginous areas may become hypertrophic and malodorous, and even mild disease can affect the quality of life . In occasional cases, the lesions may develop into squamous cell carcinomas . Additionally, liver injury and contact allergies have also been described in patients with HHD . (Source: Journal of Dermatological Science)

Polymorphisms of FAS and FAS ligand genes and risk of skin cancer

Journal of Dermatological Science — Tue, 16 Mar 2010 14:28:25 +0100

Skin cancer is the most common form of cancer in the United States among Caucasians. DNA damage induced by ultraviolet (UV) exposure has been shown to be involved in the etiology of melanoma, squamous cell carcinoma (SCC), and basal cell carcinoma (BCC) . Under normal conditions, UV-induced DNA damage is repaired by DNA repair mechanisms, or cells with damaged DNA undergo apoptosis . Apoptosis can be triggered by one of the two pathways: an intrinsic pathway or an extrinsic pathway. In the extrinsic pathway, a death-ligand binds a death-receptor that is displayed on the cell surface of the damaged cell. FAS ligand (FASL [also known as CD95LG and TNFSF6]) is one such death-ligand, and FAS (also known as CD95, APO-1, and TNFRSF6) is the corresponding death-receptor. Without the ability to un...

Decreased fibroblast contractile activity and reduced fibronectin expression are involved in skin photoaging

Journal of Dermatological Science — Tue, 16 Mar 2010 14:28:25 +0100

Skin aging is the result of both intrinsic and extrinsic factors. Extrinsic aging is mainly due to photo-damage caused by ultraviolet (UV) irradiation. A characteristic feature of photo-damaged skin is the deterioration of the dermal connective tissue. On the histological level fragmentation of interstitial collagens is observed which substantially contributes to the reduction of skin's tensile strength . While young dermal fibroblasts exhibit a sufficient capacity to adequately maintain the homeostasis of the extra cellular matrix (ECM), (photo)-aged fibroblasts not only display a decrease of their synthetic activity but are also reduced in number . Additionally, the interaction between fibroblasts and the surrounding ECM is impaired. As a consequence, the feedback-loop between matrix and...

Evidence for genetic modifiers other than filaggrin mutations in X-linked ichthyosis

Journal of Dermatological Science — Tue, 16 Mar 2010 14:28:24 +0100

X-linked ichthyosis (XLI) and ichthyosis vulgaris (IV) are the most prevalent skin disorders of cornification in humans and share a similar phenotype of generalized fine scaling of the skin . XLI is due to deletions/mutations in the steroid sulfatase (STS) gene on Xp22.32 . A lack of STS, secreted from lamellar bodies into the interstices of the horny layer, correlates with the preservation of corneodesmosomes and impaired permeability barrier homeostasis . IV is caused by mutations in the filaggrin (FLG) gene on 1q21–23 . The resulting absence/decrease of the precursor protein profilaggrin, the main constituent of the keratohyalin granules, and incomplete proteolytical cleavage of profilaggrin to FLG monomers perturbs epidermal barrier formation and stratum corneum hydration . Recently,...

Keratinocyte-derived anosmin-1, an extracellular glycoprotein encoded by the X-linked Kallmann syndrome gene, is involved in modulation of epidermal nerve density in atopic dermatitis

Journal of Dermatological Science — Tue, 16 Mar 2010 14:28:24 +0100

Conclusion: Anosmin-1 produced by epidermal keratinocytes in response to calcium concentrations or cytokines may modulate epidermal nerve density in AD. (Source: Journal of Dermatological Science)

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Spatial and temporal control of laminin-511 and -332 expressions during catagen

Journal of Dermatological Science — Tue, 16 Mar 2010 14:28:23 +0100

Conclusion: These results indicated that downregulation of laminin-511 is important for hair regression. (Source: Journal of Dermatological Science)

Laminin-511, inducer of hair growth, is down-regulated and its suppressor in hair growth, laminin-332 up-regulated in chemotherapy-induced alopecia

Journal of Dermatological Science — Tue, 16 Mar 2010 14:28:20 +0100

Conclusions: We propose that abrupt hair loss in CIA is, at least in part, caused by down-regulation of laminin-511 and up-regulation of laminin-332 at the transcriptional and translational levels. (Source: Journal of Dermatological Science)

Age-related changes of p75 Neurotrophin receptor-positive adipose-derived stem cells

Journal of Dermatological Science — Tue, 16 Mar 2010 14:28:20 +0100

Conclusion: The number of ASCs per unit of tissue weight decreased in aged mice. However, the cells possessed proliferation and differentiation potentials almost equal to those of young mice even though the differentiation potentials showed a tendency of decrease. These results raise the possibility that stem cell functions, self-renewal and multipotency, are maintained regardless of aging. (Source: Journal of Dermatological Science)

Neutrophil-dominant psoriasis-like skin inflammation induced by epidermal-specific expression of Raf in mice

Journal of Dermatological Science — Tue, 16 Mar 2010 14:28:20 +0100

Conclusion: Activation of the Raf signaling pathway is involved in the epidermal hyperplasia and the neutrophil-dominant cutaneous inflammatory reactions which are characteristics of psoriasis. (Source: Journal of Dermatological Science)

Genistein protects against UVB-induced senescence-like characteristics in human dermal fibroblast by p66Shc down-regulation

Journal of Dermatological Science — Tue, 16 Mar 2010 14:28:20 +0100

Conclusion: The results indicate that genistein protects UVB-induced senescence-like characteristics in HDFs via maintenance of antioxidant enzyme activities and modulation of mitochondrial oxidative stress through down-regulation of a p66Shc-dependent signaling pathway, which may provide potential prevention against skin aging and even photoaging. (Source: Journal of Dermatological Science)

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Systematic evaluations of skin damage irradiated by an erbium:YAG laser: Histopathologic analysis, proteomic profiles, and cellular response

Journal of Dermatological Science — Tue, 16 Mar 2010 14:28:19 +0100

Conclusion: Both proliferation and apoptosis occurred when the laser-irradiated the skin. (Source: Journal of Dermatological Science)

Extrinsic and intrinsic types of atopic dermatitis

Journal of Dermatological Science — Tue, 16 Mar 2010 14:28:19 +0100

Abstract: Atopic dermatitis (AD) can be categorized into the extrinsic and intrinsic types. Extrinsic or allergic AD shows high total serum IgE levels and the presence of specific IgE for environmental and food allergens, whereas intrinsic or non-allergic AD exhibits normal total IgE values and the absence of specific IgE. While extrinsic AD is the classical type with high prevalence, the incidence of intrinsic AD is approximately 20% with female predominance. The clinical features of intrinsic AD include relative late onset, milder severity, and Dennie-Morgan folds, but no ichthyosis vulgris or palmar hyperlinearity. The skin barrier is perturbed in the extrinsic, but not intrinsic type. Filaggrin gene mutations are not a feature of intrinsic AD. The intrinsic type is immunologically char...

Editorial board

Journal of Dermatological Science — Tue, 16 Mar 2010 14:28:19 +0100

(Source: Journal of Dermatological Science)

Dermatology Calendar

Journal of the American Academy of Dermatology — Tue, 16 Mar 2010 14:28:18 +0100

(Source: Journal of the American Academy of Dermatology)

Instructions for Category 1 CME Credit

Journal of the American Academy of Dermatology — Tue, 16 Mar 2010 14:28:18 +0100

(Source: Journal of the American Academy of Dermatology)

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Information for Readers

Journal of the American Academy of Dermatology — Tue, 16 Mar 2010 14:28:18 +0100

(Source: Journal of the American Academy of Dermatology)

Journal of the American Academy of Dermatology — Tue, 16 Mar 2010 14:28:18 +0100

(Source: Journal of the American Academy of Dermatology)

Editorial Board

Journal of the American Academy of Dermatology — Tue, 16 Mar 2010 14:28:18 +0100

(Source: Journal of the American Academy of Dermatology)

March iotaderma (#194)

Journal of the American Academy of Dermatology — Tue, 16 Mar 2010 14:28:17 +0100

(Source: Journal of the American Academy of Dermatology)

Iotaderma #195

Journal of the American Academy of Dermatology — Tue, 16 Mar 2010 14:28:15 +0100

(Source: Journal of the American Academy of Dermatology)

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Pantheon der Dermatologie. Herausragende historische Personlichkeiten

Journal of the American Academy of Dermatology — Tue, 16 Mar 2010 14:28:14 +0100

The Pantheon in Rome survives today as one of the triumphs of Western architecture. It was erected between 120 and 124 AD by the Emperor Hadrian as a temple dedicated to the multiple gods of Rome. An eighteenth century depiction of it, in masterful perspective, by Giovanni Paolo Panini, now in the National Gallery of Art in Washington, DC graces the cover of this unique tribute to the “deities” of dermatology. It is fittingly entitled Pantheon der Dermatologie. (Source: Journal of the American Academy of Dermatology)

CD34+ connective tissue nevi: Are they unusual?

Journal of the American Academy of Dermatology — Tue, 16 Mar 2010 14:28:14 +0100

To the Editor: A 1-year-old white male with a 6-month history of “raised bumps” overlying the dorsal surface of his neck was brought to our dermatology clinic for evaluation. An agminated patch of white papules was identified on the suboccipital neck (). Nuchal ultrasound was unremarkable. A 3-mm punch biopsy demonstrated spindle cell proliferation within the papillary dermis, without significant atypia (, A). Vascularity was slightly increased. The overlying epidermis was unremarkable. Laboratory tests for Ulex europaeus, S-100, CD68, muscle-specific actin, and smooth muscle actin were negative. The spindle cells and visualized vascular structures stained strongly positive for CD34 (, B). After a thorough Web-based literature search, we were unable to find any reports of CD34+ stainin...

Phenytoin-induced acute generalized exanthemous pustulosis

Journal of the American Academy of Dermatology — Tue, 16 Mar 2010 14:28:14 +0100

To the Editor: A 57-year-old African American male with a history of a seizure disorder caused by a traumatic head injury presented to the emergency department with a recent onset of multiple pustular lesions that started on his face and spread to his trunk and upper extremities. He had presented to the same emergency department 5 days earlier in status epilepticus. He was treated with 1 g phenytoin for the first time in addition to increased doses of his other medicines (lorazepam and levetiracetam). His seizure resolved and he was discharged 2 days later on increased doses of levetiracetam and valproic acid. (Source: Journal of the American Academy of Dermatology)

Acquired combined nutritional deficiency presenting as psoriasiform dermatitis

Journal of the American Academy of Dermatology — Tue, 16 Mar 2010 14:28:14 +0100

To the Editor: Nutritional deficiency, a prevalent problem worldwide, remains rare in developed countries. In the United States, acquired nutritional deficiencies have been reported in patients with anorexia nervosa, malabsorption syndromes, those on long-term parenteral nutrition, and patients with food allergies. Given the significant morbidity and sometimes mortality associated with certain nutritional deficiencies, their prompt recognition, diagnosis, and treatment by clinicians is of great importance. Many nutritional deficiencies have classic cutaneous presentations that are valuable clinical diagnostic tools. However, combined nutritional deficiencies often put forth a mixed clinical picture easily mistaken for another condition. There is a paucity of reports of cutaneous presentati...

Refractory oral ulcers with multiple immunoglobulin G/immunoglobulin A autoantibodies without skin lesions

Journal of the American Academy of Dermatology — Tue, 16 Mar 2010 14:28:14 +0100

To the Editor: Current molecular diagnostics have characterized many new autoimmune bullous diseases that traditional descriptive dermatology would not have been able to define. Herein we report a case of refractory oral ulcers with immunoblots that were confusing, causing difficulty in making a definitive diagnosis. (Source: Journal of the American Academy of Dermatology)

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Myxoinflammatory fibroblastic sarcoma on the thigh

Journal of the American Academy of Dermatology — Tue, 16 Mar 2010 14:28:14 +0100

To the Editor: Myxoinflammatory fibroblastic sarcoma (MIFS) is a slow growing, low grade tumor reported as a soft tissue tumor affecting the distal extremities. It was first described in 1998 by Meis-Kindblom and Kindblom and Montgomery et al. Although it was described by different names—acral MIFS and inflammatory myxohyaline tumor of distal extremities with virocyte or Reed-Sternberg–like cells—it described the same entity of histologic features. The reported histologic similarities included numerous inflammatory cells (plasma cells, granulocytes, eosinophils, and lymphocytes), fibrosis, and scattered, large, bizarre tumor cells resembling Reed-Sternberg–like cells in an abundant myxoid extracellular matrix. Clinically, it is described in all age groups (4-91 yrs of age), occurs...

Narrowband ultraviolet B phototherapy influences serum folate levels in patients with vitiligo

Journal of the American Academy of Dermatology — Tue, 16 Mar 2010 14:28:14 +0100

To the Editor: We read with interest the article by Rose et al in the August 2009 issue of the Journal. Ultraviolet B light phototherapy (UVB) is generally considered the safest form of systemic psoriasis therapy in pregnancy. We commend the authors for creating a study to examine the photodegradation of serum folate after exposure to narrowband UVB (nbUVB), given that folate deficiency in the first trimester of pregnancy could predispose to the development of neural tube defects. (Source: Journal of the American Academy of Dermatology)

Sentinel node biopsy: Not the standard of care for melanoma

Journal of the American Academy of Dermatology — Tue, 16 Mar 2010 14:28:13 +0100

To the Editor: The International Sentinel Node Society (ISNS) opinion, that sentinel node biopsy (SNB) “is standard of care,” is not supported by clinical evidence and warrants scrutiny. Their commentary contradicts recent multidisciplinary Australian guidelines that state that “Patients with a melanoma greater than 1.0 mm in thickness be given the opportunity to discuss SNB to provide staging and prognostic information” but deliberately do not state that SNB should be considered standard of care. (Source: Journal of the American Academy of Dermatology)

The 3S technique: Another minimally invasive technique in the treatment of saphenous varicose veins

Journal of the American Academy of Dermatology — Tue, 16 Mar 2010 14:28:13 +0100

To the Editor: I read with interest the article by Nijsten et al in the January 2009 issue of the Journal that describes three minimally invasive techniques in the treatment of saphenous varicose veins: foam sclerotherapy, endovenous laser therapy, and radiofrequency ablation. Another procedure—the 3S saphenectomy (the 3S technique)—should be added to theses techniques. The 3S technique associates the surgical sectioning and sclerotherapy of saphenous veins under local anesthesia. It has been developed in France mainly by Vin et al. Many angiophlebologists learned this technique during the educational program of the European School of Phlebology in Paris. It is useful in the following instances: (1) when surgery is not recommended because of an advanced age and/or in case of a leg ul...

Hidradenitis suppurativa markedly decreases quality of life and professional activity

Journal of the American Academy of Dermatology — Tue, 16 Mar 2010 14:28:13 +0100

To the Editor: We read with great interest the comprehensive review by Alikhan et al in the April 2009 issue of the Journal and would like to comment on our own recent findings regarding hidradenitis suppurativa (HS) and the Dermatology Life Quality Index (DLQI). (Source: Journal of the American Academy of Dermatology)

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Concern regarding the safety of tumor necrosis factor-alfa antagonists in pregnancy

Journal of the American Academy of Dermatology — Tue, 16 Mar 2010 14:28:13 +0100

To the Editor: Choosing appropriate, safe treatment for pregnant patients with psoriasis can be challenging. Although tumor necrosis factor–alfa (TNFα) antagonists are considered category B drugs according to the US Food and Drug Administration (FDA), Carter et al reported a disturbing association of infliximab and etanercept with congenital anomalies associated with the vertebral, anal, cardiovascular, tracheoesophageal, renal, limb (VACTERL) syndrome. In their review of more than 120000 adverse events of patients on TNFα antagonist therapy, they found 61 congenital anomalies occurring at higher than expected frequencies. No reports of congenital anomalies were reported in patients taking adalimumab; however, the database included entries only through 2005, which was relatively soon a...

A case of lymphoepithelioma-like carcinoma of the skin associated with Epstein–Barr virus infection

Journal of the American Academy of Dermatology — Tue, 16 Mar 2010 14:28:12 +0100

We report herein a case of EBV-positive LELCS. An 82-year-old female presented with a red nodule on the right cheek. Histologically, the entire dermis was occupied by atypical tumor cell nests with dense lymphocytic infiltration. Neoplastic cells were strongly positive for cytokeratin 14 but were negative for cytokeratins 19 and 20. EBV genomes in neoplastic cells were detected by polymerase chain reaction analysis and in situ hybridization for EBV-encoded RNA, suggesting an association with EBV. (Source: Journal of the American Academy of Dermatology)

Coexistent Kaposi sarcoma, cryptococcosis, and Mycobacterium avium intracellulare in a solitary cutaneous nodule in a patient with AIDS: Report of a case and literature review

Journal of the American Academy of Dermatology — Tue, 16 Mar 2010 14:28:12 +0100

We present a report of a 63-year-old man with AIDS who was diagnosed with coexistent Kaposi sarcoma (KS), Cryptococcus neoformans, and Mycobacterium avium intracellulare in a single, solitary lesion. A literature review identified 11 cases of patients with AIDS and cutaneous lesions with co-existent KS and other infectious organisms. To our knowledge, this is the first report of coexistent KS, C neoformans, and M avium intracellulare in the same cutaneous lesion in a patient with AIDS. (Source: Journal of the American Academy of Dermatology)

Change of Address

Journal of the American Academy of Dermatology — Tue, 16 Mar 2010 14:28:12 +0100

(Source: Journal of the American Academy of Dermatology)

Erratum

Journal of the American Academy of Dermatology — Tue, 16 Mar 2010 14:28:12 +0100

Hossler EW. Caterpillars and moths. Part I. Dermatologic manifestations of encounters with Lepidoptera. J Am Acad Dermatol 2010;62:1-10. Hossler EW. Caterpillars and moths. Part II. Dermatologic manifestations of encounters with Lepidoptera. J Am Acad Dermatol 2010;62:13-28. (Source: Journal of the American Academy of Dermatology)

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Antioxidants and their chemopreventive properties in dermatology

Journal of the American Academy of Dermatology — Tue, 16 Mar 2010 14:28:12 +0100

Dialogues in Dermatology, a monthly audio program from the American Academy of Dermatology, contains discussions between dermatologists on timely topics. Commentaries from Dialogues Editor-in-Chief Jacqueline M. Junkins-Hopkins, MD, are provided after each discussion as a topic summary and are provided here as a special service to readers of the Journal of the American Academy of Dermatology. (Source: Journal of the American Academy of Dermatology)

Pyoderma gangrenosum: A review and update on new therapies

Journal of the American Academy of Dermatology — Tue, 16 Mar 2010 14:28:12 +0100

Pyoderma gangrenosum is a rare and often painful skin disease that can be unpredictable in its response to treatment. There is currently no gold standard of treatment or published algorithm for choice of therapy. The majority of data comes from case studies that lack a standard protocol not only for treatment administration but also for the objective assessment of lesion response to a specific therapy. This review provides an update to the treatment of pyoderma gangrenosum with a particular focus on new systemic therapies. (Source: Journal of the American Academy of Dermatology)

Prospective controlled clinical and histopathologic study of hidradenitis suppurativa treated with the long-pulsed neodymium:yttrium-aluminium-garnet laser

Journal of the American Academy of Dermatology — Tue, 16 Mar 2010 14:28:11 +0100

Conclusions: Long-pulsed neodymium:yttrium-aluminium-garnet laser, together with topical benzoyl peroxide and clindamycin, is significantly more effective than topical benzoyl peroxide and clindamycin alone for the treatment of HS. Preliminary review of histopathology suggests the mechanism of action is destruction of the hair follicle. The overall success of the treatment in both clearing pre-existing lesions and preventing new eruptions, coupled with high patient satisfaction, makes the neodymium:yttrium-aluminium-garnet laser a promising treatment advance for this highly disabling condition. (Source: Journal of the American Academy of Dermatology)

Midline/paramedian longitudinal matrix excision with flap reconstruction: Alternative surgical techniques for evaluation of longitudinal melanonychia

Journal of the American Academy of Dermatology — Tue, 16 Mar 2010 14:28:11 +0100

Conclusion: The different flaps provide elegant local alternatives to second-intention healing and maximize cosmetic and functional results after matrix excision with narrow margins for longitudinal melanonychia. (Source: Journal of the American Academy of Dermatology)

Online Images in Dermatology Will Return Soon

Journal of the American Academy of Dermatology — Tue, 16 Mar 2010 14:28:11 +0100

(Source: Journal of the American Academy of Dermatology)

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Volunteers Needed

Journal of the American Academy of Dermatology — Tue, 16 Mar 2010 14:28:10 +0100

(Source: Journal of the American Academy of Dermatology)

American Board of Dermatology Examination Dates

Journal of the American Academy of Dermatology — Tue, 16 Mar 2010 14:28:10 +0100

(Source: Journal of the American Academy of Dermatology)

Answers to CME examination

Journal of the American Academy of Dermatology — Tue, 16 Mar 2010 14:28:10 +0100

(Source: Journal of the American Academy of Dermatology)

CME examination

Journal of the American Academy of Dermatology — Tue, 16 Mar 2010 14:28:10 +0100

(Source: Journal of the American Academy of Dermatology)

Urticarial lesions: If not urticaria, what else? The differential diagnosis of urticaria: Part II. Systemic diseases

Journal of the American Academy of Dermatology — Tue, 16 Mar 2010 14:28:09 +0100

There are a number of systemic disorders that can manifest with urticarial skin lesions, including urticarial vasculitis, connective tissue diseases, hematologic diseases, and autoinflammatory syndromes. All of these conditions may enter into the differential diagnosis of ordinary urticaria. In contrast to urticaria, urticarial syndromes may manifest with skin lesions other than wheals, such as papules, necrosis, vesicles, and hemorrhages. Lesions may have a bilateral and symmetrical distribution; individual lesions have a long duration, and their resolution frequently leaves marks, such as hyperpigmentation or bruising. Moreover, systemic symptoms, such as fever, asthenia, and arthralgia, may be present. The most important differential diagnosis in this group is urticarial vasculitis, whi...

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CME examination

Journal of the American Academy of Dermatology — Tue, 16 Mar 2010 14:28:09 +0100

(Source: Journal of the American Academy of Dermatology)

Answers to CME examination

Journal of the American Academy of Dermatology — Tue, 16 Mar 2010 14:28:09 +0100

(Source: Journal of the American Academy of Dermatology)

Urticarial lesions: If not urticaria, what else? The differential diagnosis of urticaria: Part I. Cutaneous diseases

Journal of the American Academy of Dermatology — Tue, 16 Mar 2010 14:28:09 +0100

Acute urticaria is self-limiting, and a cause can be identified in many patients. Chronic urticaria is a long lasting disease, and patients are commonly examined for an autoimmune origin and for associated diseases. Although the diagnosis of urticaria is straightforward in most patients, it may pose some difficulties at times and it may require a careful differential diagnosis with a number of conditions. Urticarial syndromes comprise both cutaneous and systemic disorders. Part I of this two-part series focuses on the clinical and histologic features that characterize common urticaria and on the cutaneous diseases that may manifest with urticarial lesions and must be considered in the differential diagnosis.Learning objectives: After completing the learning activity, participants should be...

The Vasculature of Nonmelanocytic Skin Tumors in Reflectance Confocal Microscopy: Vascular Features of Basal Cell Carcinoma [skINsight]

Archives of Dermatology — Mon, 15 Mar 2010 19:50:59 +0100

(Source: Archives of Dermatology)

A Rare Case of Vulvar Melanoma in a Young Woman Who Frequently Tanned in Tanning Parlors [Correspondence]

Archives of Dermatology — Mon, 15 Mar 2010 19:50:59 +0100

(Source: Archives of Dermatology)

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Combined Multifocal Indeterminate Cell Histiocytosis and Basal Cell Carcinoma [Correspondence]

Archives of Dermatology — Mon, 15 Mar 2010 19:50:59 +0100

(Source: Archives of Dermatology)

Distribution of Skin Type and Skin Cancer in Organ Transplant Recipients [Research Letters]

Archives of Dermatology — Mon, 15 Mar 2010 19:50:59 +0100

(Source: Archives of Dermatology)

Analysis of the Benign to Malignant Ratio of Lesions Biopsied by a General Dermatologist Before and After the Adoption of Dermoscopy [Research Letters]

Archives of Dermatology — Mon, 15 Mar 2010 19:50:59 +0100

(Source: Archives of Dermatology)

Rapidly Growing Gingival Mass in an Infant--Diagnosis [Off-Center Fold]

Archives of Dermatology — Mon, 15 Mar 2010 19:50:59 +0100

(Source: Archives of Dermatology)

Rapidly Growing Gingival Mass in an Infant--Quiz Case [Off-Center Fold]

Archives of Dermatology — Mon, 15 Mar 2010 19:50:59 +0100

(Source: Archives of Dermatology)

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Multiple Facial Papules and Macrocephaly--Diagnosis [Off-Center Fold]

Archives of Dermatology — Mon, 15 Mar 2010 19:50:59 +0100

(Source: Archives of Dermatology)

Multiple Facial Papules and Macrocephaly--Quiz Case [Off-Center Fold]

Archives of Dermatology — Mon, 15 Mar 2010 19:50:59 +0100

(Source: Archives of Dermatology)

Generalized Lentiginosis, Short Stature, and Multiple Cutaneous Nodules--Diagnosis [Off-Center Fold]

Archives of Dermatology — Mon, 15 Mar 2010 19:50:59 +0100

(Source: Archives of Dermatology)

Generalized Lentiginosis, Short Stature, and Multiple Cutaneous Nodules--Quiz Case [Off-Center Fold]

Archives of Dermatology — Mon, 15 Mar 2010 19:50:59 +0100

(Source: Archives of Dermatology)

Large Nodular Plaque on Leg in the Setting of Chronic Lymphedema--Diagnosis [Off-Center Fold]

Archives of Dermatology — Mon, 15 Mar 2010 19:50:59 +0100

(Source: Archives of Dermatology)

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Large Nodular Plaque on Leg in the Setting of Chronic Lymphedema--Quiz Case [Off-Center Fold]

Archives of Dermatology — Mon, 15 Mar 2010 19:50:58 +0100

(Source: Archives of Dermatology)

Need for a New Skin Cancer Management Strategy [Special Article]

Archives of Dermatology — Mon, 15 Mar 2010 19:50:58 +0100

This article explores multiple opportunities for the development of a disease management system regarding skin cancer that will provide structured and multidisciplinary care. (Source: Archives of Dermatology)

Sun, Drugs, and Skin Cancer: A Continuing Saga [Editorial]

Archives of Dermatology — Mon, 15 Mar 2010 19:50:58 +0100

(Source: Archives of Dermatology)

Dermatologists, General Practitioners, and the Best Method to Biopsy Suspect Melanocytic Neoplasms [Editorial]

Archives of Dermatology — Mon, 15 Mar 2010 19:50:58 +0100

(Source: Archives of Dermatology)

Why the Evidence for Skin Cancer Screening Is Insufficient: Lessons From Prostate Cancer Screening [Evidence-Based Dermatology: Research Commentary]

Archives of Dermatology — Mon, 15 Mar 2010 19:50:58 +0100

(Source: Archives of Dermatology)

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Second Malignant Neoplasm Occurring Years After Hyperthermic Isolated Limb Perfusion for Melanoma [Observation]

Archives of Dermatology — Mon, 15 Mar 2010 19:50:58 +0100

Conclusions Because long-term survivors of regionally advanced melanoma, although rare, do exist, candidates for HILP should be warned of the risk of long-term development of nonmelanoma secondary cancers. The risk-benefit balance of high-dose local chemotherapy should be carefully evaluated in the light of these findings, especially in patients with early-stage melanoma or other non–life-threatening medical conditions. (Source: Archives of Dermatology)

Trends in Dermatology: Melanoma Incidence [Notable Notes]

Archives of Dermatology — Mon, 15 Mar 2010 19:50:58 +0100

(Source: Archives of Dermatology)

Historical, Clinical, and Dermoscopic Characteristics of Thin Nodular Melanoma [Observation]

Archives of Dermatology — Mon, 15 Mar 2010 19:50:58 +0100

Conclusions The often unremarkable clinical presentation of NM necessitates physicians and patients to be wary of new or changing lesions. Dermoscopy may help increase suspicion in early NM because dermoscopic features are typically more suggestive of malignancy than clinical ones. We hope that secondary prevention efforts combined with prompt dermatologic consultations will allow for the timely diagnosis and management of NM. (Source: Archives of Dermatology)

Hydroxyurea-Associated Dermatomyositis-like Eruption Demonstrating Abnormal Epidermal p53 Expression: A Potential Premalignant Manifestation of Chronic Hydroxyurea and UV Radiation Exposure [Observation]

Archives of Dermatology — Mon, 15 Mar 2010 19:50:58 +0100

Conclusions We suggest that dermatomyositis-like eruption and hydroxyurea-associated squamous dysplasia represent similar clinical manifestations of a common underlying chronic phototoxic process involving aberrant keratinocyte p53 expression mediated by hydroxyurea's antimetabolite properties and UV radiation exposure. Accordingly, we suggest that dermatomyositis-like eruption, previously considered a benign entity, may represent a premalignant precursor of hydroxyurea-associated nonmelanoma skin cancers warranting discontinuation of hydroxyurea therapy. (Source: Archives of Dermatology)

Melanoma Associated With Long-term Voriconazole Therapy: A New Manifestation of Chronic Photosensitivity [Observation]

Archives of Dermatology — Mon, 15 Mar 2010 19:50:58 +0100

Conclusions We recommend surveillance for skin cancer formation in all patients who require long-term voriconazole treatment, particularly those who manifest signs or symptoms of photosensitivity or chronic photodamage. Further study of the mechanism underlying voriconazole photosensitivity and oncogenesis is warranted. Published online January 18, 2010 (doi:10.1001/archdermatol.2009.362). (Source: Archives of Dermatology)

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Incidence and Clinical Predictors of a Subsequent Nonmelanoma Skin Cancer in Solid Organ Transplant Recipients With a First Nonmelanoma Skin Cancer: A Multicenter Cohort Study [Study]

Archives of Dermatology — Mon, 15 Mar 2010 19:50:58 +0100

Conclusions Development of a first NMSC confers a high risk of a subsequent NMSC in transplant recipients. Intensive long-term dermatologic follow-up of these patients is advisable. (Source: Archives of Dermatology)

Gene Expression Patterns of Normal Human Skin, Actinic Keratosis, and Squamous Cell Carcinoma: A Spectrum of Disease Progression [Study]

Archives of Dermatology — Mon, 15 Mar 2010 19:50:58 +0100

Conclusions The finding of similar differentially expressed genes in AK and SCC confirms that AK is a precursor lesion of SCC and indicates that they are closely related genetically. Clear elucidation of these relationships will be critical to improving therapeutic approaches. (Source: Archives of Dermatology)

Incidence Estimate of Nonmelanoma Skin Cancer in the United States, 2006 [Study]

Archives of Dermatology — Mon, 15 Mar 2010 19:50:58 +0100

Conclusions The number of skin cancers in Medicare beneficiaries increased dramatically over the years 1992 to 2006, due mainly to an increase in the number of affected individuals. Using nationally representative databases, we provide evidence of much higher overall totals of skin cancer diagnoses and patients in the US population than previous estimates. These data give the most complete evaluation to date of the underrecognized epidemic of skin cancer in the United States. (Source: Archives of Dermatology)

Prevalence of a History of Skin Cancer in 2007: Results of an Incidence-Based Model [Study]

Archives of Dermatology — Mon, 15 Mar 2010 19:50:58 +0100

Conclusions My incidence-based model indicates that the prevalence of a skin cancer history is about 5 times higher than that of breast or prostate cancer and greater than the 31-year prevalence of all other cancers combined. Despite their high frequency, population-based incidence and burden data for BSC and SCC are largely lacking. (Source: Archives of Dermatology)

Sensitivity of Fluorescence In Situ Hybridization for Melanoma Diagnosis Using RREB1, MYB, Cep6, and 11q13 Probes in Melanoma Subtypes [Study]

Archives of Dermatology — Mon, 15 Mar 2010 19:50:58 +0100

Conclusions Heterogeneous changes in melanoma occur at the molecular level, and the changes are different among melanoma subtypes. Clonal abnormalities in chromosome 6 with increased copies of the short arm relative to the long arm are common in all melanoma subtypes, suggesting that isochromosome 6 is common in all variants of cutaneous melanoma subtypes. An increase in copy number of 11q13 is most frequent in chronically sun-damaged melanomas. (Source: Archives of Dermatology)

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December 2009 Archives Web Quiz Winner [Archives Web Quiz Winner]

Archives of Dermatology — Mon, 15 Mar 2010 19:50:58 +0100

(Source: Archives of Dermatology)

Increased Risk of Second Primary Cancers After a Diagnosis of Melanoma [Study]

Archives of Dermatology — Mon, 15 Mar 2010 19:50:57 +0100

Conclusions Melanoma survivors have an approximately 9-fold increased risk of developing subsequent melanoma compared with the general population. The risk remains elevated more than 20 years after the initial melanoma diagnosis. This increased risk may be owing to behavioral factors, genetic susceptibility, or medical surveillance. Although the percentage of subsequent primary melanomas thicker than 1 mm is lower than for the first of multiple primary melanomas, it is still substantial. Melanoma survivors should remain under surveillance not only for recurrence but also for future primary melanomas and other cancers. (Source: Archives of Dermatology)

Selection of Patients for Long-term Surveillance With Digital Dermoscopy by Assessment of Melanoma Risk Factors [Study]

Archives of Dermatology — Mon, 15 Mar 2010 19:50:57 +0100

Conclusions We suggest an individualized surveillance plan, with digital dermoscopy performed at follow-up intervals of 3 months for patients with FAMMM syndrome and 6 to 12 months (depending on additional risk factors) for those with AMS. Patients with multiple common nevi and no additional risk factors had no benefit from sequential digital dermoscopy. (Source: Archives of Dermatology)

Economic Burden of Melanoma in the Elderly Population: Population-Based Analysis of the Surveillance, Epidemiology, and End Results (SEER)-Medicare Data [Study]

Archives of Dermatology — Mon, 15 Mar 2010 19:50:57 +0100

Conclusions Melanoma care presents a significant economic burden in the elderly population, particularly in late-stage disease. If effective, prevention and early detection efforts may reduce the economic burden. (Source: Archives of Dermatology)

The Role of Circumstances of Diagnosis and Access to Dermatological Care in Early Diagnosis of Cutaneous Melanoma: A Population-Based Study in France [Study]

Archives of Dermatology — Mon, 15 Mar 2010 19:50:57 +0100

Conclusion Easy access of patients to dermatologists, information campaigns targeting elderly people, and education of general practitioners are complementary approaches to improving early detection. (Source: Archives of Dermatology)

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The Impact of Partial Biopsy on Histopathologic Diagnosis of Cutaneous Melanoma: Experience of an Australian Tertiary Referral Service [Study]

Archives of Dermatology — Mon, 15 Mar 2010 19:50:57 +0100

Conclusions Among melanoma seen at a tertiary referral center, histopathologic misdiagnosis is more common for melanomas that have been assessed with punch and shave biopsy than with excisional biopsy. Regardless of biopsy method, adverse outcomes due to misdiagnosis may occur. However, such adverse events are more commonly associated with punch biopsy than with shave and excisional biopsy. The use of punch and shave biopsy also leads to increased microstaging inaccuracy. (Source: Archives of Dermatology)

Review of Dermatology and Syphilis [Archives a Century Ago]

Archives of Dermatology — Mon, 15 Mar 2010 19:50:57 +0100

(Source: Archives of Dermatology)

This Month in Archives of Dermatology [This Month in Archives of Dermatology]

Archives of Dermatology — Mon, 15 Mar 2010 19:50:57 +0100

(Source: Archives of Dermatology)

About This Journal [About This Journal]

Archives of Dermatology — Mon, 15 Mar 2010 19:50:57 +0100

(Source: Archives of Dermatology)

3 Cases of Dissecting Cellulitis of the Scalp Treated With Adalimumab: Control of Inflammation Within Residual Structural Disease [Observation]

Archives of Dermatology — Mon, 15 Mar 2010 19:43:14 +0100

Conclusions Adalimumab is effective for treatment of DCS. Relapse on discontinuation of therapy can be expected depending on persisting structural disease. Continuous treatment or combined surgical resection of involved areas could be necessary for definitive resolution of disease.Published online March 15, 2010 (doi:10.1001/archdermatol.2010.16). (Source: Archives of Dermatology)

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Psoriasis Tied to Raised Heart Risk

MedicineNet Skin General — Mon, 15 Mar 2010 07:00:00 +0100

Title: Psoriasis Tied to Raised Heart RiskCategory: Health NewsCreated: 3/13/2010 2:10:00 PMLast Editorial Review: 3/15/2010 (Source: MedicineNet Skin General)

Collision tumors: CAMEL, METRO and other acronyms

JDDG — Mon, 15 Mar 2010 00:00:00 +0100

We describe two exceptional collision tumors, namely: a 63-year-old woman revealing a melanocytic tumor within a trichoblastoma and a 71-year-old woman with a squamous cell carcinoma colonized by dendritic cells of a melanoma. Both neoplasms showed two different tumor components with intimate relationship. The lesions are labeled in a "playful" way with the acronyms METRO (MElanocytic tumor +TRichOblastoma) and CAMEL (CArcinoma +MELanoma) to facilitate memorization. (Source: JDDG)

Successful treatment of acquired C1 inhibitor deficiency with icatibant

Clinical And Experimental Dermatology — Sun, 14 Mar 2010 00:00:00 +0100

(Source: Clinical And Experimental Dermatology)

Seven-point checklist reasonably effective for diagnosing melanoma

MedWire News - Dermatology — Sat, 13 Mar 2010 14:04:04 +0100

The seven-point checklist algorithm for detecting melanoma is relatively effective for predicting melanoma, but use of complementary information increases accuracy, show study results. (Source: MedWire News - Dermatology)

AAD: One Pill a Day Works Against Onychomycosis (CME/CE)

MedPage Today Dermatology — Sat, 13 Mar 2010 12:43:02 +0100

MIAMI BEACH (MedPage Today) -- A single high-dose tablet of an oral antifungal taken once a day cleared onychomycosis with efficacy similar to conventional treatment with two lower doses of the same drug, researchers found. (Source: MedPage Today Dermatology)

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What is the role of ultrasound evaluation of lymph nodes in patients with high-grade squamous cell carcinoma of the head and neck?

British Journal of Dermatology — Sat, 13 Mar 2010 00:00:00 +0100

(Source: British Journal of Dermatology)

Sarcoidal granulomas in a cosmetic tattoo in association with pulmonary sarcoidosis

JDDG — Sat, 13 Mar 2010 00:00:00 +0100

We report on a patient, who developed sarcoidal granulomas within the black pigment of his tattoos. This subsequently led to the diagnosis of pulmonary sarcoidosis. (Source: JDDG)

AAD: Once-Daily Antifungal Clears Athlete's Foot (CME/CE)

MedPage Today Dermatology — Fri, 12 Mar 2010 16:07:22 +0100

MIAMI BEACH (MedPage Today) -- Application of a topical antifungal once a day led to complete or marked clearance of interdigital tinea pedis and negative culture in almost 90% of patients involved in a small clinical study reported here. (Source: MedPage Today Dermatology)

AAD: Restarting Anti-TNF Agent Works in Relapsed Psoriasis (CME/CE)

MedPage Today Dermatology — Fri, 12 Mar 2010 15:51:40 +0100

MIAMI BEACH (MedPage Today) -- A majority of patients with relapsed psoriasis regained control of the disease when retreated with the tumor necrosis factor (TNF) inhibitor adalimumab (Humira), results of a small clinical study showed. (Source: MedPage Today Dermatology)

KEYNOTE ADDRESS: Evidence-Based Practice: What It Is, Why We Need It

Advances in Skin & Wound Care — Fri, 12 Mar 2010 14:09:55 +0100

No abstract available (Source: Advances in Skin & Wound Care)

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AAD: Psoriasis Increases Pregnancy Risks (CME/CE)

MedPage Today Dermatology — Fri, 12 Mar 2010 12:43:02 +0100

MIAMI BEACH (MedPage Today) -- Pregnant women with psoriasis had a significantly increased risk of poor outcomes, including spontaneous abortion, preterm birth, preeclampsia, placenta previa, and ectopic pregnancy, data from a retrospective chart review showed. (Source: MedPage Today Dermatology)

What Is Hyperhidrosis (Excessive Sweating)? What Causes Hyperhidrosis?

Dermatology News From Medical News Today — Fri, 12 Mar 2010 08:00:00 +0100

Hyperhidrosis, also known as polyhidrosis or sudorrhea means excessive sweating; sweating too much. Hidrosis means sweating, while hyper means too much, or excessively. The excessive sweating may be either localized in specific parts of the body, or generalized (everywhere). Most cases of excessive sweating tend to start during a person's teenage years - their adolescence... (Source: Dermatology News From Medical News Today)

Health Tip: IBD May Contribute to Other Health Problems

MedicineNet Skin General — Fri, 12 Mar 2010 07:00:00 +0100

Title: Health Tip: IBD May Contribute to Other Health ProblemsCategory: Health NewsCreated: 3/11/2010 10:10:00 AMLast Editorial Review: 3/12/2010 (Source: MedicineNet Skin General)

Health Tip: Risk Factors for Melanoma

MedicineNet Skin General — Fri, 12 Mar 2010 07:00:00 +0100

Title: Health Tip: Risk Factors for MelanomaCategory: Health NewsCreated: 3/11/2010 10:10:00 AMLast Editorial Review: 3/12/2010 (Source: MedicineNet Skin General)

Melasma

MedicineNet Skin General — Fri, 12 Mar 2010 07:00:00 +0100

Title: MelasmaCategory: Diseases and ConditionsCreated: 3/12/2010 5:07:00 PMLast Editorial Review: 3/12/2010 5:07:18 PM (Source: MedicineNet Skin General)

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Factors predicting acne in Chinese adolescents clarified

MedWire News - Dermatology — Fri, 12 Mar 2010 00:00:00 +0100

Genetic predisposition, psychologic stress, insomnia, and high calorie consumption, amongst other factors, all significantly predict the onset of acne in Chinese adolescents, say researchers. (Source: MedWire News - Dermatology)

Drug-drug interactions common with methotrexate or cyclosporine for psoriasis

MedWire News - Dermatology — Fri, 12 Mar 2010 00:00:00 +0100

Researchers warn of the potential risk for drug-drug interactions in patients prescribed methotrexate or cyclosporine for psoriasis, and the substantial impact of these interactions on healthcare resources. (Source: MedWire News - Dermatology)

Characterization of an in vivo model for the study of eyelash biology and trichomegaly: mouse eyelash morphology, development, growth cycle, and anagen prolongation by bimatoprost

British Journal of Dermatology — Fri, 12 Mar 2010 00:00:00 +0100

Conclusions This study shows that mouse eyelashes offer an excellent in vivo model for the quantitative and qualitative analysis of eyelash morphology, development, growth cycle, exogen and pharmacological modulation. This model will help to elucidate the unknown molecular controls of eyelash growth, and to develop novel drugs to treat eyelash disorders. (Source: British Journal of Dermatology)

Novel plant metalloproteinase from Dieffenbachia seguine causes fingertip necrosis

British Journal of Dermatology — Fri, 12 Mar 2010 00:00:00 +0100

(Source: British Journal of Dermatology)

Giant warts in a kidney transplant patient: regression with sirolimus

British Journal of Dermatology — Fri, 12 Mar 2010 00:00:00 +0100

(Source: British Journal of Dermatology)

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Systemic isotretinoin in the treatment of rosacea – doxycycline- and placebo-controlled, randomized clinical study

JDDG — Fri, 12 Mar 2010 00:00:00 +0100

Conclusions: Isotretinoin 0.3 mg/kg is an effective and well-tolerated therapy option for the treatment of rosacea subtype II and III and can therefore be used successfully as an alternative to therapy with oral antibiotics. (Source: JDDG)

Paraffinoma

JDDG — Fri, 12 Mar 2010 00:00:00 +0100

The subcutaneous infiltration of liquid paraffin is still used for penile enlargement. The procedure has many complications. A late problem is the development of foreign body granulomas known as paraffinomnas. They may be necrotic and ulcerated, requiring acute, radical surgical excision. (Source: JDDG)

Effect of inflammation on positive margins of basal cell carcinomas

Australasian Journal of Dermatology — Fri, 12 Mar 2010 00:00:00 +0100

Conclusion: The study has shown the majority of negative re-excisions were from lesions on the head which had had an initial surgical procedure. However, the evidence is not strong enough to advocate a protocol for dealing with positive margins. A larger sample size that encompassed all three factors that affect outcome, that is, the location of lesion, type of lesion and type of excision carried out, would be required in order to make a more definitive statement on protocol change for treatment of basal cell carcinoma. (Source: Australasian Journal of Dermatology)

4-Methylumbelliferone inhibits tumour cell growth and the activation of stromal hyaluronan synthesis by melanoma cell-derived factors

British Journal of Dermatology — Fri, 12 Mar 2010 00:00:00 +0100

Conclusions 4-MU is a potent inhibitor of hyaluronan synthesis, induction of stromal hyaluronan accumulation by tumour cells, and fibroblast and melanoma cell proliferation, and results suggest that 4-MU may have potential as a tumour cell anti-invasive and antiproliferative agent. (Source: British Journal of Dermatology)

Percutaneous collagen induction. Scarless skin rejuvenation: fact or fiction?

Clinical And Experimental Dermatology — Fri, 12 Mar 2010 00:00:00 +0100

In this study, the immediate effects of PCI on the skin were assessed, including the systemic inflammatory response and the production and gene expression of transforming growth factor (TGF) isoforms [beta]1, [beta]2 and [beta]3. Eighty rats were split into four groups: group 1 (n = 24; PCI plus skin care); group 2 (n = 24; skin care only); group 3 (n = 24; PCI only) and group 4 (n = 8; controls). Microarray analysis showed that TGF-[beta]3, an essential marker for preventing scarring, was upregulated and expressed for 2 weeks postoperatively. PCI might offer a regenerative therapy to improve skin appearance and quality and to improve or even prevent scarring. (Source: Clinical And Experimental Dermatology)

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Request For Re-Examination Of Ceftobiprole Submitted To CHMP

Dermatology News From Medical News Today — Thu, 11 Mar 2010 21:00:00 +0100

Basilea Pharmaceutica Ltd... (Source: Dermatology News From Medical News Today)

Current best evidence from dermatology literature