MedWorm: Dermatology

Copy Number Variations on Chromosome 4q26–27 Are Associated with Cantu Syndrome

Dermatology — Thu, 02 Feb 2012 17:38:55 +0100

Dermatology (DOI:10.1159/000333800) (Source: Dermatology)

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Index

Dermatologic Clinics — Thu, 02 Feb 2012 17:38:41 +0100

(Source: Dermatologic Clinics)

Clinical Meaning in Skin-specific Quality of Life Instruments: A Comparison of the Dermatology Life Quality Index and Skindex Banding Systems

Dermatologic Clinics — Thu, 02 Feb 2012 17:38:41 +0100

This article focuses on the anchor-based banding approach and reviews methods to assign clinical meaning to QOL measures, specifically the Dermatology Life Quality Index (DLQI) and Skindex. This article also includes pilot data that compares the DLQI and Skindex using these previously validated banding systems. (Source: Dermatologic Clinics)

Quality-of-Life Instruments: Evaluation of the Impact of Psoriasis on Patients

Dermatologic Clinics — Thu, 02 Feb 2012 17:38:40 +0100

The negative impact of psoriasis on a patient's quality of life (QoL) is well documented in the literature. Patients often suffer poor self-esteem, difficulties in social interactions, and significant psychological distress. It is, therefore, critically important that a clinician evaluate the extent to which the disease impacts a patient's QoL. This chapter reviews several validated and reliable generic, dermatology-specific, and disease-specific QoL instruments useful in measuring the impact of psoriasis on patient's QoL. These QoL instruments can be especially helpful in identifying those patients who would most benefit from systemic or biologic therapy. (Source: Dermatologic Clinics)

Melasma Quality of Life Measures

Dermatologic Clinics — Thu, 02 Feb 2012 17:38:40 +0100

This article addresses these methods, which could be useful to those desiring to develop the MELASQOL in other languages. (Source: Dermatologic Clinics)

Health-Related Quality of Life in Dermatology: Introduction and Overview

Dermatologic Clinics — Thu, 02 Feb 2012 17:38:40 +0100

This article introduces a compendium of articles that address HRQoL in dermatology across a spectrum of diseases and ways that HRQoL can be incorporated in the clinical and research settings. (Source: Dermatologic Clinics)

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Forthcoming Issues

Dermatologic Clinics — Thu, 02 Feb 2012 17:38:40 +0100

(Source: Dermatologic Clinics)

Dermatologic Clinics — Thu, 02 Feb 2012 17:38:40 +0100

(Source: Dermatologic Clinics)

Contributors

Dermatologic Clinics — Thu, 02 Feb 2012 17:38:40 +0100

(Source: Dermatologic Clinics)

Immunology in clinic review series; focus on autoinflammatory diseases: update on monogenic autoinflammatory diseases: the role of interleukin (IL)‐1 and an emerging role for cytokines beyond IL‐1

Clinical and Experimental Immunology — Thu, 02 Feb 2012 11:18:22 +0100

OTHER THEMES PUBLISHED IN THIS IMMUNOLOGY IN THE CLINIC REVIEW SERIESAllergy, Host Responses, Cancer, Type 1 diabetes and viruses, Metabolic diseases.SummaryThe disease‐based discovery of the molecular basis for autoinflammatory diseases has led not only to a rapidly growing number of clinically and genetically identifiable disorders, but has unmantled key inflammatory pathways such as the potent role of the alarm cytokine interleukin (IL)‐1 in human disease. Following its initial failures in the treatment of sepsis and the moderate success in the treatment of rheumatoid arthritis, IL‐1 blocking therapies had a renaissance in the treatment of a number of autoinflammatory conditions, and IL‐1 blocking therapies have been Food and Drug Administration (FDA)‐approved for the treatmen...

Lack of Sunlight May Raise Stroke Risk

The Doctors Lounge - Dermatology — Thu, 02 Feb 2012 05:00:00 +0100

Study found those who got less exposure were more likely to suffer an attack (Source: The Doctors Lounge - Dermatology)

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Photostabilization of Ascorbic Acid with Citric Acid, Tartaric Acid and Boric Acid in Cream Formulations

International Journal of Cosmetic Science — Thu, 02 Feb 2012 05:00:00 +0100

SynopsisThe present study involves the evaluation of the effect of certain stabilizers, i.e. citric acid (CT), tartaric acid (TA) and boric acid (BA) on the degradation of ascorbic acid (AH2) in oil‐in‐water cream formulations exposed to the UV light and stored in the dark. The apparent first‐order rate constants (0.34–0.95×10−3 min−1 in light, 0.38–1.24×10−2 day−1 in dark) for the degradation reactions in the presence of the stabilizers have been determined. These rate constants have been used to derive the second‐order rate constants (0.26–1.45×10−2 M−1 min−1 in light, 3.75–8.50×10−3 M−1 day−1) for the interaction of AH2 and the individual stabilizers. These stabilizers are effective in causing the inhibition of the rate of degradation of AH2 both ...

Lipocalin‐type prostaglandin D synthase as a marker for the proliferative potential of melanocyte‐lineage cells in the human skin

The Journal of Dermatology — Thu, 02 Feb 2012 05:00:00 +0100

In conclusion, L‐PGDS expression may contribute to the restricted proliferation of epidermal melanocytes, but conversely its overexpression may reflect the dysregulated proliferation of melanoma cells. (Source: The Journal of Dermatology)

Femoral head osteonecrosis after long‐term topical corticosteroid treatment in a psoriasis patient

The Journal of Dermatology — Thu, 02 Feb 2012 05:00:00 +0100

(Source: The Journal of Dermatology)

Blaschkitis‐like eruptions with hypodontia and low IκB kinase gamma expression

The Journal of Dermatology — Thu, 02 Feb 2012 05:00:00 +0100

(Source: The Journal of Dermatology)

Ber‐EP4 is a useful marker for follicular germinative cell differentiation of cutaneous epithelial neoplasms

The Journal of Dermatology — Thu, 02 Feb 2012 05:00:00 +0100

In this study, we performed immunohistochemical staining of 31 cases of basal cell carcinoma (BCC); 20 cases of trichoblastoma (TB), including ten cases of nodular type, eight cases of cribriform type (trichoepithelioma) and two cases of columnar type (desmoplastic trichoepithelioma); 16 cases of actinic keratosis (AK); and 10 cases each of Bowen’s disease, poroma and seborrheic keratosis. Six cases of BCC and AK were co‐lesions of both neoplasms. In normal skin tissue, Ber‐EP4 reacted positively with the secretory portion of eccrine glands and follicular germinative cells at the lower end of catagen hairs. Neoplastic cells in 97% of cases with BCC reacted positively with Ber‐EP4 in at least 5% of neoplastic cells. Those in 90% with nodular type TB and 50% with trichoepithelioma al...

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Incontinentia pigmenti with NEMO mutation in a Japanese family

The Journal of Dermatology — Thu, 02 Feb 2012 05:00:00 +0100

(Source: The Journal of Dermatology)

Topical Treatments for Atopic DermatitisTopical Treatments for Atopic Dermatitis

Medscape Today Headlines — Thu, 02 Feb 2012 04:00:00 +0100

Proper skin care can improve skin barrier function, reducing susceptibility to triggers of flares, but what skin care regimen works best? Pediatric Nursing (Source: Medscape Today Headlines)

Eosinophilia during Psoriasis Treatment with TNF Antagonists

Dermatology — Wed, 01 Feb 2012 23:00:00 +0100

Dermatology (DOI:10.1159/000334805) (Source: Dermatology)

Linear Pitting and Splinter Haemorrhages Are More Commonly Seen in the Nails of Patients with Established Psoriasis in Comparison to Psoriatic Arthritis

Dermatology — Wed, 01 Feb 2012 23:00:00 +0100

Dermatology (DOI:10.1159/000335571) (Source: Dermatology)

Evaluation of the German Guideline for Chronic Pruritus: Results of a Retrospective Study on 385 Patients

Dermatology — Wed, 01 Feb 2012 23:00:00 +0100

Dermatology (DOI:10.1159/000335782) (Source: Dermatology)

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Tanning Salons Lie About Health Risks Says Congressional Panel

Health News from Medical News Today — Wed, 01 Feb 2012 22:00:00 +0100

A report compiled by the U.S. House Energy and Commerce Committee slates tanning salons for not making the risks clear to their customers. The committee asked for a thorough investigation to find out whether tanning salons across the country make it clear to their clients the health issues associated with the services they offer. In a sting operation, the committee investigators made enquiries at 300 indoor tanning salons around the United States... (Source: Health News from Medical News Today)

Effectiveness of the Novel Herbal Medicine, KIOM-MA, and Its Bioconversion Product, KIOM-MA128, on the Treatment of Atopic Dermatitis

Research Letters in Nanotechnology — Wed, 01 Feb 2012 11:48:01 +0100

This study was conducted to determine if oral administration of the novel herbal medicine, KIOM-MA, and its Lactobacillus acidophilus-fermented product, KIOM-MA128, has therapeutic properties for the treatment of atopic dermatitis (AD). Using AD-induced BALB/c mice by Ovalbumin and aluminum hydroxide, the effectiveness of KIOM-MA and KIOM-MA128 on AD was evaluated. Oral administration of KIOM-MA and KIOM-MA128 reduced major clinical signs of AD including erythema/darkening, edema/papulation, excoriations, lichenification/prurigo, and dryness. Interestingly, KIOM-MA128 more significantly improved AD-related symptoms including decrease of IgE level in the plasma as well as reduction of scratching behavior, skin severity in the AD BALB/c model. HPLC analysis showed the significant changes in ...

First Drug to Target Cause of Cystic Fibrosis Approved

MedicineNet Skin General — Wed, 01 Feb 2012 07:00:00 +0100

Title: First Drug to Target Cause of Cystic Fibrosis ApprovedCategory: Health NewsCreated: 2/1/2012 11:01:00 AMLast Editorial Review: 2/1/2012 (Source: MedicineNet Skin General)

fexofenadine, Allegra, Allegra Allergy, Allegra Hives, Children's Allegra

MedicineNet Skin General — Wed, 01 Feb 2012 07:00:00 +0100

Title: fexofenadine, Allegra, Allegra Allergy, Allegra Hives, Children's AllegraCategory: MedicationsCreated: 12/31/1997Last Editorial Review: 2/1/2012 (Source: MedicineNet Skin General)

Use of digital infrared imaging in the assessment of childhood psoriasis

Skin Research and Technology — Wed, 01 Feb 2012 05:00:00 +0100

(Source: Skin Research and Technology)

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Characterization of the miRNA profile in UVB‐irradiated normal human keratinocytes

Experimental Dermatology — Wed, 01 Feb 2012 05:00:00 +0100

AbstractThe aim of this study was to assess the effects of ultraviolet B (UVB) irradiation on microRNA (miRNA) expression in normal human keratinocytes. Global miRNA expression profiles of primary cultures of normal human keratinocytes 4 and 24 hours post‐irradiation were studied using miRNA microarray with further confirmation by real‐time PCR. We found that upon 30 or 60 mJ/cm2 of UVB radiation, the expression of 44 miRNAs were up‐ or downregulated more than 2‐fold compared to non‐irradiated keratinocytes. MiRNAs were either up‐ or downregulated after 4 hours, and then either returned to normal levels or remained affected after 24 hours, resulting in 4 distinct patterns of miRNA expression change. It appears that acute exposure of keratinocytes to UVB radiation results in sev...

Spectrofluorescence of Skin and Hair

International Journal of Cosmetic Science — Wed, 01 Feb 2012 05:00:00 +0100

We examined several sources of skin including in vivo human and ex vivo pig, sheep, goat, and cow skin. We also analyzed various types of mature hair characterized by degree of melanin content. These analyses provided us with a fundamental understanding of the effects of melanin distribution in hair fibers and aided with the identification of fluorophores present in hair.© 2012 The Authors ICS © 2012 Society of Cosmetic Scientists and the Société Française de Cosmétologie (Source: International Journal of Cosmetic Science)

Accuracy of dermoscopic criteria for the diagnosis of psoriasis, dermatitis, lichen planus and pityriasis rosea

British Journal of Dermatology — Wed, 01 Feb 2012 05:00:00 +0100

Conclusions: PP, LP, PR and dermatitis show specific dermoscopic patterns that may aid their clinical diagnosis. Certain combinations of dermoscopic features can reliably predict the diagnosis of PP. (Source: British Journal of Dermatology)

Blaschkoid distribution of cylindromas in a germline CYLD mutation carrier.

British Journal of Dermatology — Wed, 01 Feb 2012 05:00:00 +0100

(Source: British Journal of Dermatology)

Fractional Laser Resurfacing for Acne Scars: A Review

British Journal of Dermatology — Wed, 01 Feb 2012 05:00:00 +0100

AbstractThis review investigates the effectiveness of ablative and non‐ablative Fractional Photothermolysis (FP) lasers for treating facial acne scars. 26 studies (13=ablative FP; 13=non‐ablative FP) published between year‐2003 to January 2011 were reviewed. Quantitative and qualitative data from each article were examined and analysed. 4 studies were split‐face randomised controlled studies (RCTs). Whilst the data analysed where all clinically relevant and significant, there were some methodological differences between the studies. Outcomes included subjective and objective assessment of scar appearance, pre‐ and postoperative treatment, side effects and pain scores. A small number of studies used 3D Optical Profiling Imaging and histology for objective assessment. Even allowing...

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A rare heterozygous TRAF6 variant is associated with hypohidrotic ectodermal dysplasia

British Journal of Dermatology — Wed, 01 Feb 2012 05:00:00 +0100

AbstractMutation of the genes encoding components of the TNFα‐like (tumour necrosis factor α) pathway involved in signal transduction between the ectoderm and the mesenchyme during embryonic development causes hypohidrotic ectodermal dysplasia (HED), resulting from the abnormal differentiation of tooth buds, hair follicles and eccrine sweat glands. Two phenotypically indistinguishable forms of HED, X‐linked recessive and autosomal (dominant or recessive), have been discerned in mice and humans.1 The X‐linked form (OMIM #305100) is caused by mutations in the ED1 gene, which encodes two principal ectodysplasins. EDA‐A1 is recognized by receptor EDA1R (ectodysplasin A1 receptor), causing the recruitment of an adaptor, EDARADD (EDA1R‐associated death domain), which interacts with T...

Serum leptin, adiponectin, resistin and ghrelin levels in psoriatic patients treated with cyclosporin

The Journal of Dermatology — Wed, 01 Feb 2012 05:00:00 +0100

AbstractCyclosporin has various effects on adipose tissue and glucose metabolism. This situation may lead to changes in serum levels of adipocyte‐derived cytokines which have influence on the pathogenesis of psoriasis. The aim of this study was to evaluate the effect of cyclosporin treatment on some adipocyte‐derived cytokines in psoriatic patients. This case–control study was performed between June 2009 and March 2010, at the Department of Dermatology of Meram School of Medicine. Serum leptin, adiponectin, resistin and ghrelin levels were assessed in 26 patients with psoriasis before and after cyclosporin treatment and body mass index‐matched 26 healthy control subjects. The adipokines levels were compared between the groups. Serum leptin, ghrelin, resistin and adiponectin levels ...

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