MedWorm: Dermatology

Burns Patients Awaiting Skin Grafts: Human Embryonic Stem-Cells Could Be Used To Generate Temporary Skin

Dermatology News From Medical News Today — Fri, 20 Nov 2009 08:00:00 +0100

A study in this week's edition of The Lancet reports that the use of human embryonic stem-cells (hESCs) is a promising alternative for producing temporary skin substitutes for patients awaiting skin grafts after, for example, serious burn injuries. The article is the work of Dr Christine Baldeschi, INSERM and Institute for Stem Cell Therapy and Exploration of Monogenic Diseases, Evry Cedex, France, and colleagues. (Source: Dermatology News From Medical News Today)

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Is the Dermatology Life Quality Index really time-sensitive?

Journal of the European Academy of Dermatology and Venereology — Fri, 20 Nov 2009 00:00:00 +0100

(Source: Journal of the European Academy of Dermatology and Venereology)

Birt–Hogg–Dubé syndrome: clinical and genetic studies of 10 French families

British Journal of Dermatology — Fri, 20 Nov 2009 00:00:00 +0100

Conclusions We report here the largest series to date of French patients with BHDS. We noted a high prevalence of thyroid nodules and renal cysts. However, the lack of a control group does not allow assessment of whether or not such association with BHDS is fortuitous. (Source: British Journal of Dermatology)

Instructions for Category 1 CME Credit

Journal of the American Academy of Dermatology — Thu, 19 Nov 2009 14:05:38 +0100

(Source: Journal of the American Academy of Dermatology)

Information for Readers

Journal of the American Academy of Dermatology — Thu, 19 Nov 2009 14:05:38 +0100

(Source: Journal of the American Academy of Dermatology)

Journal of the American Academy of Dermatology — Thu, 19 Nov 2009 14:05:38 +0100

(Source: Journal of the American Academy of Dermatology)

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Editorial Board

Journal of the American Academy of Dermatology — Thu, 19 Nov 2009 14:05:38 +0100

(Source: Journal of the American Academy of Dermatology)

November iotaderma (#190)

Journal of the American Academy of Dermatology — Thu, 19 Nov 2009 14:05:38 +0100

(Source: Journal of the American Academy of Dermatology)

Iotaderma #191

Journal of the American Academy of Dermatology — Thu, 19 Nov 2009 14:05:38 +0100

(Source: Journal of the American Academy of Dermatology)

Subject index

Journal of the American Academy of Dermatology — Thu, 19 Nov 2009 14:05:38 +0100

(Source: Journal of the American Academy of Dermatology)

Author index

Journal of the American Academy of Dermatology — Thu, 19 Nov 2009 14:05:38 +0100

(Source: Journal of the American Academy of Dermatology)

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Cover Sheet for Index

Journal of the American Academy of Dermatology — Thu, 19 Nov 2009 14:05:38 +0100

(Source: Journal of the American Academy of Dermatology)

Dermatology Calendar

Journal of the American Academy of Dermatology — Thu, 19 Nov 2009 14:05:37 +0100

(Source: Journal of the American Academy of Dermatology)

Life with epidermolysis bullosa (EB): Etiology, diagnosis, multidisciplinary care and therapy

Journal of the American Academy of Dermatology — Thu, 19 Nov 2009 14:05:37 +0100

This is the first new book devoted to epidermolysis bullosa (EB) to hit the shelves since Jo-David Fine's masterpiece that came out about a decade ago; the book is packed with epidemiologic data from the National EB Registry in the United States, which he founded. (Source: Journal of the American Academy of Dermatology)

Requisites in dermatology: General dermatology

Journal of the American Academy of Dermatology — Thu, 19 Nov 2009 14:05:37 +0100

When asked to review this book, I wondered why someone would write another “general dermatology,” book and I further wondered how I could sit down and read another textbook of dermatology. Then I read the forward. The purpose of the series is to present topics—in this case, diseases—with an emphasis on the key points essential for residents and practicing clinicians. Their purpose has been fulfilled. (Source: Journal of the American Academy of Dermatology)

Circumscribed palmar hypokeratosis

Journal of the American Academy of Dermatology — Thu, 19 Nov 2009 14:05:37 +0100

To the Editor: Circumscribed palmar or plantar hypokeratosis (CPH) is a new entity recently described by Perez et al in 2002. To the best of our knowledge, only a few cases have been reported in the literature. It may be underdiagnosed, because most of the cases are asymptomatic, and sometimes it is misdiagnosed as palmar porokeratosis or Bowen disease. A 47-year-old woman presented to our department with an asymptomatic, solitary, circumscribed patch of depressed skin on the left thenar palm that had been present for approximately 10 years. There was no history of trauma or other notable incident. Her medications consisted of hydroxychloroquine, 200 mg daily, 5 days a week, for chronic cutaneous lupus. The physical examination revealed a 1 × 1 cm, annular, well demarcated erythematous de...

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Congenital dacryocystocele

Journal of the American Academy of Dermatology — Thu, 19 Nov 2009 14:05:37 +0100

To the Editor: A 5-day-old female was seen in consultation by the pediatric dermatology service for a bluish discoloration over the right medial infraorbital area. This resembled a bruise at 2 days of age. On the fifth day of life, a gradually enlarging nodule was noted in the same area that caused some distortion of her lower eyelid. On examination, there was a 9- × 7-mm, very firm blue nodule present inferior to the right medial canthus (). There was no purulent drainage. The differential diagnosis included a deep infantile hemangioma or a midline developmental defect; however, a diagnosis of dacryocystocele was favored because of the classic location and presentation within several days of birth. The pediatric dermatologists recommended an ultrasound and ophthalmologic evaluation, but ...

Persistent agmination of lymphomatoid papulosis evolving to classical lesions of lymphomatoid papulosis

Journal of the American Academy of Dermatology — Thu, 19 Nov 2009 14:05:37 +0100

To the Editor: Heald et al described seven patients with what they called persistent agmination of lymphomatoid papulosis (LyP) and classified them as a distinct clinical subset within CD30+ lymphoproliferative disorders. Patients had waxing and waning papules and nodules within a persistent erythematous and scaly plaque, histopathologically compatible with a LyP, but with a different clinical behavior. We observed a similar case with the same clinical presentation but a distinct clinical evolution. A 27-year-old male without medical history had a 4-month history of several asymptomatic, stable nodules between 10 and 20 mm in size that appeared on the anterior aspect of his right thigh within a 15-cm erythematous, scaly, noninfiltrated patch (). A biopsy of one of the nodules was performed...

Radiation recall dermatitis induced by erlotinib

Journal of the American Academy of Dermatology — Thu, 19 Nov 2009 14:05:37 +0100

We report a case of radiation recall dermatitis induced by erlotinib, a selective epidermal growth factor receptor (EGFR) inhibitor. (Source: Journal of the American Academy of Dermatology)

Videodermatoscopy enhances diagnostic capability in psoriatic balanitis

Journal of the American Academy of Dermatology — Thu, 19 Nov 2009 14:05:36 +0100

To the Editor: Balanitis is an inflammatory condition of the glans penis that may be caused by a wide range of dermatologic conditions, including psoriasis. Psoriatic balanitis is clinically characterized by erythematous, nonscaling plaques most commonly located proximally on the glans and under the prepuce. Most often, genital psoriasis is part of a more generalized disease process, but in the case of exclusively penile involvement, the correct diagnosis may be difficult to make, and several investigations, including a skin biopsy, are often necessary. (Source: Journal of the American Academy of Dermatology)

Patient preferences for dermatology visits

Journal of the American Academy of Dermatology — Thu, 19 Nov 2009 14:05:36 +0100

To the Editor: In recent years, multiple sources have reported long wait times for new patient appointments in some major metropolitan cities across the United States. However, little information has been collected pertaining to patient perceptions of these wait times and consumer preferences for dermatology visits compared to other providers in terms of access. (Source: Journal of the American Academy of Dermatology)

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Reporting clinical trials: Why one plus one does not equal two

Journal of the American Academy of Dermatology — Thu, 19 Nov 2009 14:05:36 +0100

To the Editor: We read with interest Thiboutot et al's November 2008 report of safety and efficacy of a product containing clindamycin phosphate 1.2% and benzoyl peroxide 2.5% for treatment of acne. In the report, Thiboutot et al present combined data from two randomized controlled trials (RCTs) as if the two RCTs were in fact one large RCT. Unfortunately, such an approach is invalid. (Source: Journal of the American Academy of Dermatology)

Physiologic changes in vascular birthmarks during early infancy: Mechanisms and clinical implications

Journal of the American Academy of Dermatology — Thu, 19 Nov 2009 14:05:36 +0100

To the Editor: In the April 2009 issue of the Journal, Cordoro et al stated that physiologic vascular changes in infants may alter the appearance of some vascular birthmarks; they incorrectly suggested that these changes contribute to the efficacy of pulsed dye laser (PDL) treatment of port wine stains (PWS) in infancy. We have recently shown that high energy PDL of PWS before 6 months of age offers the best chance of eradication of these lesions. Factors related to laser–tissue interactions are far more responsible for this high cure rate than are physiologic changes in the vasculature. (Source: Journal of the American Academy of Dermatology)

Nonmelanoma skin cancer in vitiligo patients

Journal of the American Academy of Dermatology — Thu, 19 Nov 2009 14:05:36 +0100

To the Editor: In the June 2009 issue of the Journal, Hexsel et al reported the incidence of nonmelanoma skin cancer (NMSC) in a cohort of patients with vitiligo. In the “Introduction” section, they noted that the frequency of skin cancer in patients with vitiligo seems to be uncommon, with only a few reports in the literature. They identified 477 patients at their hospital with vitiligo, six of whom (42% of the study group) had a NMSC. Four were basal cell carcinomas, and two were squamous cell carcinomas (SCCs). The pathology specimens were stained for the presence of melanocytes. Two of the six cancers arose in vitiliginous skin, the other four in skin containing melanocytes. They calculated the incidence of skin cancer in white patients with vitiligo and concluded that NMSC is as c...

Tinea capitis treatment in Spain

Journal of the American Academy of Dermatology — Thu, 19 Nov 2009 14:05:36 +0100

In this report the authors compared the efficacy and safety of terbinafine hydrochloride oral granules with that of oral griseofulvin suspension in children with tinea capitis. (Source: Journal of the American Academy of Dermatology)

Freedom of expression or protectionism in the debate on sentinel node biopsy in melanoma

Journal of the American Academy of Dermatology — Thu, 19 Nov 2009 14:05:35 +0100

To the Editor: The Organizing Committee of the 6th Biennial International Sentinel Node Society (ISNS) Meeting in Sydney, Australia, held from February 18-20, 2008, refused to allow any presentations from the podium that did not support sentinel node biopsy (SNB) in melanoma. The members of the international panel who prepared the subsequent “consensus statement” all represented the same opinion. All but one of the references cited in the May 2009 commentary by Balch et al in the Journal were written by the authors themselves. As a result, it is my opinion that both the commentary and the consensus statement are biased. (Source: Journal of the American Academy of Dermatology)

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Volunteers Needed

Journal of the American Academy of Dermatology — Thu, 19 Nov 2009 14:05:32 +0100

(Source: Journal of the American Academy of Dermatology)

Correction

Journal of the American Academy of Dermatology — Thu, 19 Nov 2009 14:05:32 +0100

Patel RV, Clark LN, Lebwohl M, Weinberg JM. Treatments for psoriasis and the risk of malignancy. J Am Acad Dermatol 2009;60:1001-17. On page 1002 of the article above, the following statement was incorrect: Patients with mild psoriasis have a relative risk of 1.42 and 3.18 of developing Hodgkin's lymphoma and CTCL, respectively. Patients with severe psoriasis have a relative risk of 4.10 and 10.75 of developing Hodgkin's lymphoma and CTCL, respectively. (Source: Journal of the American Academy of Dermatology)

Correction

Journal of the American Academy of Dermatology — Thu, 19 Nov 2009 14:05:32 +0100

Lupi O, Bartlett BL, Haugen RN, Dy LC, Sethi A, Klaus SN, Machado Pinto J, Bravo F, Tyring SK. Tropical dermatology: Tropical diseases caused by protozoa. J Am Acad Dermatol 2009;60:897-925. (Source: Journal of the American Academy of Dermatology)

Immunomodulatory therapy of cutaneous T-cell lymphoma: A multimodality approach in advanced disease

Journal of the American Academy of Dermatology — Thu, 19 Nov 2009 14:05:32 +0100

Dialogues in Dermatology, a monthly audio program from the American Academy of Dermatology, contains discussions between dermatologists on timely topics. Commentaries from Dialogues Editor-in-Chief Jacqueline M. Junkins-Hopkins, MD, are provided after each discussion as a topic summary and are provided here as a special service to readers of the Journal of the American Academy of Dermatology. (Source: Journal of the American Academy of Dermatology)

Pain associated with aminolevulinic acid-photodynamic therapy of skin disease

Journal of the American Academy of Dermatology — Thu, 19 Nov 2009 14:05:32 +0100

Conclusion: Gamma-aminobutyric acid receptors, cold/menthol receptors (transient receptor potential cation channel, subfamily M, member 8), and vanilloid/capsaicin receptors (transient receptor potential cation channel, subfamily V, member 1) may be involved in pain perception during ALA-PDT and are therefore worthy of further investigation. (Source: Journal of the American Academy of Dermatology)

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Initial presentation of stasis dermatitis mimicking solitary lesions: A previously unrecognized clinical scenario

Journal of the American Academy of Dermatology — Thu, 19 Nov 2009 14:05:31 +0100

Conclusion: Stasis dermatitis may present as a solitary lesion mimicking a neoplasm. Early recognition of stasis dermatitis can lead to appropriate treatment and possibly prevent further morbidity. (Source: Journal of the American Academy of Dermatology)

Microscopically differentiating dermatophytes from sock fibers

Journal of the American Academy of Dermatology — Thu, 19 Nov 2009 14:05:31 +0100

Conclusion: While textile fibers may be present in KOH preparations, their general appearance typically differs from that of dermatophytes; an observer who is familiar with these distinctions will be able to differentiate between the two. (Source: Journal of the American Academy of Dermatology)

Surgical management of congenital dermatofibrosarcoma protuberans

Journal of the American Academy of Dermatology — Thu, 19 Nov 2009 14:05:31 +0100

Congenital dermatofibrosarcoma protuberans (DFSP) is a rare tumor with varying clinical presentations that is commonly misdiagnosed. Treatment of congenital DFSP is complicated by delays in diagnosis and its propensity for subclinical spread. Of 61 reported cases, 11 (18%) were treated with Mohs micrographic surgery (MMS) and 46 (75%) were treated with wide local excision (WLE). One case was treated with imatinib, and the remaining 3 did not differentiate between receiving MMS or WLE. In the cases of congenital DFSP treated with MMS the clearance rate was 100% with an average follow-up of 4.3 years. The clearance rate seen with WLE was 89% with an average follow-up period of 1.9 years. The average margins taken during MMS (1.7 cm) were smaller than those taken with WLE (2.8 cm). Fifty perc...

Change of Address

Journal of the American Academy of Dermatology — Thu, 19 Nov 2009 14:05:28 +0100

(Source: Journal of the American Academy of Dermatology)

Answers to CME examination

Journal of the American Academy of Dermatology — Thu, 19 Nov 2009 14:05:28 +0100

(Source: Journal of the American Academy of Dermatology)

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CME examination

Journal of the American Academy of Dermatology — Thu, 19 Nov 2009 14:05:28 +0100

(Source: Journal of the American Academy of Dermatology)

Earn CME and MOC Credits Through a New Online e-Blue Feature

Journal of the American Academy of Dermatology — Thu, 19 Nov 2009 14:05:28 +0100

(Source: Journal of the American Academy of Dermatology)

Angiogenesis in cutaneous disease: Part II

Journal of the American Academy of Dermatology — Thu, 19 Nov 2009 14:05:28 +0100

This review will discuss the role of angiogenesis in specific cutaneous diseases. Scientific evidence now points to the role of angiogenesis in tumor development and many other cutaneous disorders. Angiogenesis is a complex process that involves angiogenic growth factors and inhibitors, many of which could be a potential target for pharmacologic intervention. Antiangiogenic agents have recently been applied to dermatologic diseases with promising efficacy.Learning objectives: After completing this learning activity, participants should be able to recognize cutaneous diseases where angiogenesis is likely to be an important factor, recognize scenarios where angiogenic therapy may be useful in conjunction with traditional therapies, and be able to use angiogenic-mediating agents in the treatm...

American Board of Dermatology Examination Dates

Journal of the American Academy of Dermatology — Thu, 19 Nov 2009 14:05:28 +0100

(Source: Journal of the American Academy of Dermatology)

Answers to CME examination

Journal of the American Academy of Dermatology — Thu, 19 Nov 2009 14:05:28 +0100

(Source: Journal of the American Academy of Dermatology)

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CME examination

Journal of the American Academy of Dermatology — Thu, 19 Nov 2009 14:05:28 +0100

(Source: Journal of the American Academy of Dermatology)

Angiogenesis in cutaneous disease: Part I

Journal of the American Academy of Dermatology — Thu, 19 Nov 2009 14:05:27 +0100

Angiogenesis is an important process in normal physiology and disease pathogenesis. Angiogenesis is controlled in a healthy body by a system of angiogenic growth factors and angiogenesis inhibitors. When angiogenic growth factors are predominantly expressed, blood vessel growth occurs and disease may result. Successful therapies have been developed that target growth factors, their receptors, or the cascade pathways that are activated by growth factor/receptor interactions. There is good evidence that angiogenesis plays an important role in a wide range of cutaneous maladies, and angiogenesis-targeting therapies are playing an increasing role in the management of dermatologic disease. Cutaneous angiogenesis offers an exciting new arena for targeted dermatologic therapeutics.Learning object...

Prognostic factors for cure following treatment of onychomycosis

Journal of the European Academy of Dermatology and Venereology — Thu, 19 Nov 2009 00:00:00 +0100

Conclusions Several host-related factors at baseline and positive culture at 24 weeks had negative effects on cure of onychomycosis 72 weeks after treatment was initiated. This finding merits a large study on prognostic outcome factors in onychomycosis. (Source: Journal of the European Academy of Dermatology and Venereology)

Tissue and blood superoxide dismutase activity and malondialdehyde level in leprosy

Journal of the European Academy of Dermatology and Venereology — Thu, 19 Nov 2009 00:00:00 +0100

Conclusion Oxidative stress was observed in both tissues and blood of MB patients and in tissues of PB patients, denoting its crucial involvement in the pathogenesis of leprosy. This can constitute an important tool in prognosis, treatment and control of leprosy. (Source: Journal of the European Academy of Dermatology and Venereology)

Multiple trichoepitheliomas – a novel mutation in the CYLD gene

Journal of the European Academy of Dermatology and Venereology — Thu, 19 Nov 2009 00:00:00 +0100

Conclusions The predominating tumours define the classification of these three entities. Nevertheless, studies suggest that can simply represent phenotypic variations of the same disease spectrum, sharing common genetic mutations. (Source: Journal of the European Academy of Dermatology and Venereology)

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Efficacy of narrowband UVB vs. PUVA in patients with early-stage mycosis fungoides

Journal of the European Academy of Dermatology and Venereology — Thu, 19 Nov 2009 00:00:00 +0100

Conclusions Our results confirm that phototherapy is a safe, effective and well-tolerated, first-line therapy in patients with early-stage cutaneous T-cell lymphoma, with prolonged disease-free remissions being achieved. It suggests that narrowband UVB is at least as effective as PUVA for treatment of early-stage MF. (Source: Journal of the European Academy of Dermatology and Venereology)

Sarcoidosis and sarcoid-like pathologies of the skin: result of a common pathological (immunodeficiency) process? – Authors' reply to the comment of Dr Luis Ignacio Gonzalez-Granado

Journal of the European Academy of Dermatology and Venereology — Thu, 19 Nov 2009 00:00:00 +0100

(Source: Journal of the European Academy of Dermatology and Venereology)

The impact of obesity on skin disease and epidermal permeability barrier status

Journal of the European Academy of Dermatology and Venereology — Thu, 19 Nov 2009 00:00:00 +0100

Conclusion Specific dermatoses as skin tags, striae distensae and plantar hyperkeratosis, could be considered as a cutaneous stigma of severe obesity. The low permeability of the skin to evaporative water loss is observed in obese subjects compared with normal weight control. Although the physiological mechanisms are still unknown, this finding has not been previously described and we believe that this may constitute a new field in the research on obesity. (Source: Journal of the European Academy of Dermatology and Venereology)

No association between nickel allergy and reporting cosmetic dermatitis from mascara or eye shadow: a cross-sectional general population study

Journal of the European Academy of Dermatology and Venereology — Thu, 19 Nov 2009 00:00:00 +0100

Conclusion Overall, no association between having nickel allergy and reporting cosmetic dermatitis from mascara or eye shadow use was found in the general population. This does not exclude a causal relationship in selected cases. (Source: Journal of the European Academy of Dermatology and Venereology)

Cetuximab-induced cutaneous toxicity

Journal of the European Academy of Dermatology and Venereology — Thu, 19 Nov 2009 00:00:00 +0100

Conclusions The most frequent cutaneous side effect reported in this series was acneiform eruption. The authors observed that all women with acneiform rash had only limited facial involvement, whereas all but one man experienced more widespread lesions of the face, the back and the chest. We found no association between the extent and severity of cutaneous eruptions (grade 1 vs. grade 2) and patients' response to therapy. (Source: Journal of the European Academy of Dermatology and Venereology)

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A simple assay for the study of human hair follicle damage induced by ionizing irradiation

Experimental Dermatology — Thu, 19 Nov 2009 00:00:00 +0100

Please cite this paper as: A simple assay for the study of human hair follicle damage induced by ionizing irradiation. Experimental Dermatology 2009.Abstract: Due to its rapidly proliferating matrix keratinocytes, the hair follicle is highly sensitive to ionizing irradiation (IR)-induced skin damage and thus an instructive and clinically relevant model organ for investigating the effects of IR on rapidly dividing epithelial-mesenchymal interaction systems. Here, we have assessed the impact of IR on organ-cultured human scalp hair follicles. We show that IR significantly inhibits the proliferation and induces apoptosis of hair follicle matrix keratinocytes, disrupts normal hair follicle pigmentation, and upregulates a number of quantitative toxicity and viability markers (oxidative stress i...

Impact of Adalimumab on Symptoms of Psoriatic Arthritis in Patients with Moderate to Severe Psoriasis: A Pooled Analysis of Randomized Clinical Trials

Dermatology — Wed, 18 Nov 2009 23:00:00 +0100

Dermatology (DOI:10.1159/000260371) (Source: Dermatology)

FDA Approves New Drug For Pain That Persists After Shingles

Dermatology News From Medical News Today — Wed, 18 Nov 2009 19:00:00 +0100

The US Food and Drug Administration (FDA) announced yesterday that it has approved Qutenza (capsaicin) 8% patch for the treatment of post-herpetic neuralgia (PHN), an often excruciating pain that can persist for weeks, months and even years in 10 to 15 per cent of people who get shingles. The medicated skin patch, which is made by Lohmann Therapie-Systems AD of Andernach, Germany and distributed in the US by NeurogesX Inc. (Source: Dermatology News From Medical News Today)

Basilea's Toctino(R) Receives Marketing Authorization In Canada

Dermatology News From Medical News Today — Wed, 18 Nov 2009 17:00:00 +0100

Basilea Pharmaceutica Ltd. announces that Toctino® (alitretinoin), a new once-daily oral treatment for adults with severe chronic hand eczema (CHE) unresponsive to potent topical corticosteroids, has obtained regulatory approval from Health Canada. "We are delighted that Health Canada has approved the use of Toctino for patients with severe chronic hand eczema unresponsive to potent topical steroids. (Source: Dermatology News From Medical News Today)

New Study Ushers In Spring-Time For Slow Inactivation

Dermatology News From Medical News Today — Wed, 18 Nov 2009 14:00:00 +0100

The December 2009 issue of the Journal of General Physiology (JGP) contains a paper by Christopher Ahern (The University of British Columbia, Vancouver) and colleagues that explores pore mutation effects in Shaker and other K+ channels using in vivo nonsense suppression technology. The study was published online November 16 (http://www.jgp.org). (Source: Dermatology News From Medical News Today)

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TAU Develops Dissolving Dressing For Wounds Packed With Infection-Fighting Antibiotics

Dermatology News From Medical News Today — Wed, 18 Nov 2009 14:00:00 +0100

Despite advances in treatment regimens and the best efforts of nurses and doctors, about 70% of all people with severe burns die from related infections. But a revolutionary new wound dressing developed at Tel Aviv University could cut that number dramatically. Prof. (Source: Dermatology News From Medical News Today)

University Of Montreal Study Reveals Danger To Fetus Of Certain Drugs

Dermatology News From Medical News Today — Wed, 18 Nov 2009 14:00:00 +0100

More than six percent of expectant mothers in Quebec consume prescription drugs that are known to be harmful to their fetuses, according to a UniversitÃ© de MontrÃ©al investigation published in the British Journal of Obstetrics and Gynaecology. Half these women will voluntarily terminate their pregnancy fearing congenital malformations, which means the abortion rate among these women is 11 percent higher than in the rest of the population. (Source: Dermatology News From Medical News Today)

International Psoriasis Council Hosts Second Educational Symposium To Increase Global Knowledge Of Psoriasis

Dermatology News From Medical News Today — Wed, 18 Nov 2009 08:00:00 +0100

Beginning Thursday, Nov. 19, 2009, the International Psoriasis Council (IPC) will host its second symposium at Baylor University Medical Center in Dallas. The two-day conference brings together dermatologists from Asia, Eastern Europe and Spain to elevate the global understanding of psoriasis and its treatment. Sessions will be facilitated by leading dermatologists and nurses dedicated to psoriasis management and research. (Source: Dermatology News From Medical News Today)

Qutenza Approved for Post-Shingles Nerve Pain

MedicineNet Skin General — Wed, 18 Nov 2009 07:00:00 +0100

Title: Qutenza Approved for Post-Shingles Nerve PainCategory: Health NewsCreated: 11/17/2009 12:10:00 PMLast Editorial Review: 11/18/2009 (Source: MedicineNet Skin General)

Tween: Child Development

MedicineNet Skin General — Wed, 18 Nov 2009 07:00:00 +0100

Title: Tween: Child DevelopmentCategory: Health and LivingCreated: 11/18/2009 10:41:00 AMLast Editorial Review: 11/18/2009 10:41:12 AM (Source: MedicineNet Skin General)

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Skin fragility and blistering with imatinib mesylate

Journal of the European Academy of Dermatology and Venereology — Wed, 18 Nov 2009 00:00:00 +0100

(Source: Journal of the European Academy of Dermatology and Venereology)

Notalgia paresthesica successfully treated with narrow-band UVB: report of five cases

Journal of the European Academy of Dermatology and Venereology — Wed, 18 Nov 2009 00:00:00 +0100

Conclusion Given the benefits achieved, we stress the interest of UVB narrow-band as a safe and well tolerated alternative treatment for notalgia paresthetica. (Source: Journal of the European Academy of Dermatology and Venereology)

Porokeratotic eccrine ostial and dermal duct naevus: report of 10 cases

Journal of the European Academy of Dermatology and Venereology — Wed, 18 Nov 2009 00:00:00 +0100

Conclusions PEODDN is a rare disorder that usually appears at birth or early childhood. It has a linear distribution following the Blaschko lines. To our knowledge this is the largest series reported in English literature and we also describe the first family case. (Source: Journal of the European Academy of Dermatology and Venereology)

Humoral deficiencies as an underlying cause of sarcoidosis of the skin

Journal of the European Academy of Dermatology and Venereology — Wed, 18 Nov 2009 00:00:00 +0100

(Source: Journal of the European Academy of Dermatology and Venereology)

The mineralocorticoid receptor as a novel player in skin biology: beyond the renal horizon?

Experimental Dermatology — Wed, 18 Nov 2009 00:00:00 +0100

Please cite this paper as: The mineralocorticoid receptor as a novel player in skin biology: beyond the renal horizon? Experimental Dermatology 2009.Abstract: The mineralocorticoid receptor (MR) and its ligand aldosterone regulate renal sodium reabsorption and blood pressure and much knowledge has been accumulated in MR physiopathology, cellular and molecular targets. In contrast, our understanding of this hormonal system in non-classical targets (heart, blood vessels, neurons, keratinocytes[hellip]) is limited, particularly in the mammalian skin. We review here the few available data that point on MR in the skin and that document cutaneous MR expression and function, based on mouse models and very limited observations in humans. Mice that overexpress the MR in the basal epidermal keratino...

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Drug-induced angioedema without urticaria: prevalence and clinical features

Journal of the European Academy of Dermatology and Venereology — Wed, 18 Nov 2009 00:00:00 +0100

Conclusions Non-steroidal anti-inflammatory drugs and antibiotics were the most common drugs causing angioedema without urticaria. The duration of onset ranged from minutes to days. After stopping the suspected drugs, symptoms disappeared within 2[ndash]5 days in most patients. (Source: Journal of the European Academy of Dermatology and Venereology)

Can blood components with age-related changes influence the ageing of endothelial cells?

Experimental Dermatology — Wed, 18 Nov 2009 00:00:00 +0100

In conclusion, our data suggest that blood components that exhibit age-related changes, such as alterations in cytoskeletal regulators and stress proteins, may be associated with endothelial cell ageing. (Source: Experimental Dermatology)

Remission of extensive intrahepatic metastasis by C-arm computed tomography guided chemoembolization in uveal melanoma

JDDG — Wed, 18 Nov 2009 00:00:00 +0100

As soon as uveal melanoma has metastasized to the liver, response rates to systemic chemotherapy are low. It can be improved by development of special locoregional procedures. A 24-year-old woman suffered from inoperable hepatic metastases which grew to life-endangering size despite both systemic chemotherapy with gemc-itabine/treosulfan and conventional intrahepatic chemoembolization with fotemustine and starch particles. We subsequently performed two angiographic C-arm CT-guided, superselective chemoembolizations of the hepatic arteries feeding the tumor, using cisplatin, starch microspheres and ethiodized oil. Following this treatment, no vital tumor tissue was detectable by MRI. This remission lasted for more than 6 months and the patient's quality of life was good. A subsequent local ...

'Wear Ur SPF' Text Reminders Increase Sunscreen Use (CME/CE)

MedPage Today Dermatology — Tue, 17 Nov 2009 14:28:27 +0100

Using text messages to remind patients to wear their sunscreen may increase their compliance, researchers said. (Source: MedPage Today Dermatology)

Innovative Strategy Could Help People Follow Doctors' Orders, Take Medications

Dermatology News From Medical News Today — Tue, 17 Nov 2009 13:00:00 +0100

People who received daily text messages reminding them to apply sunscreen were nearly twice as likely to use it as those who did not receive such messages, a new study led by a UC Davis Health System dermatologist has found. Researchers hope their findings, which appear in the November issue of the Archives of Dermatology, will inspire other health-care providers to use text messaging to encourage healthy habits in their patients, such as taking prescribed medications properly. (Source: Dermatology News From Medical News Today)

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Skin Color Gives Clues To Health

Dermatology News From Medical News Today — Tue, 17 Nov 2009 10:00:00 +0100

Researchers from the universities of Bristol and St. Andrews in the UK have found that the color of a person's skin affects how healthy and therefore attractive they appear, and have found that diet may be crucial to achieving the most desirable complexion. The work will be published in the December issue of Springer's International Journal of Primatology. (Source: Dermatology News From Medical News Today)

Health Tip: When Baby Is Teething

MedicineNet Skin General — Tue, 17 Nov 2009 07:00:00 +0100

Title: Health Tip: When Baby Is TeethingCategory: Health NewsCreated: 11/17/2009 8:10:00 AMLast Editorial Review: 11/17/2009 (Source: MedicineNet Skin General)

CKS topic review: Chilblains

NeLM - Dermatology — Tue, 17 Nov 2009 00:00:00 +0100

Source: CKS Area: Evidence > Guidelines This Topic Review from the Clinical Knowledge Service (CKS) covers the management of chilblains. (Source: NeLM - Dermatology)

Plasmacytoid dendritic cell neoplasm treated successfully with rituximab

Journal of the European Academy of Dermatology and Venereology — Tue, 17 Nov 2009 00:00:00 +0100

(Source: Journal of the European Academy of Dermatology and Venereology)

Quality of life and health-related utility analysis of adults with moderate and severe atopic dermatitis treated with tacrolimus ointment vs. topical corticosteroids

Journal of the European Academy of Dermatology and Venereology — Tue, 17 Nov 2009 00:00:00 +0100

Conclusion Treatment with 0.1% tacrolimus ointment rather than a standard topical corticosteroid ointment regimen was associated with clinically significant, incremental improvement in QoL, sustained over a 6-month period. A within-trial cost-utility estimate based on study medication cost alone suggests that tacrolimus ointment is highly cost-effective given existing willingness-to-pay thresholds. (Source: Journal of the European Academy of Dermatology and Venereology)

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Angiokeratoma regression in a Fabry disease after treatment with agalsidase-β: clinical effectiveness marker?

Journal of the European Academy of Dermatology and Venereology — Tue, 17 Nov 2009 00:00:00 +0100

(Source: Journal of the European Academy of Dermatology and Venereology)

Microalbuminuria as an early marker of renal involvement in Behcet's disease: it is associated with neurological involvement and duration of the disease

Journal of the European Academy of Dermatology and Venereology — Tue, 17 Nov 2009 00:00:00 +0100

Background Despite its nature as a systemic vasculitis, renal involvement is known to occur infrequently in Behçet's Disease (BD).Objectives Our aim was to investigate proteinuria, microhematuria and microalbuminuria in 24-h urine and evaluate subclinical or symptomatic renal involvement in BD patients.Methods Two hundred and eleven patients who fulfilled the International Behçet's Disease criteria were included in the study. After urine analysis, five of 12 patients who were found to have proteinuria underwent renal biopsy, while 199 patients without proteinuria were investigated for microalbuminuria (MA).Results A total of 34 (16.1%) patients were found to have renal involvement including 22 (11.1%) with MA and 12 with proteinuria (5.6%). Renal biopsies resulted as focal glomeruloscler...

Erythema leprosum – after treatment of Lepromatous Leprosy

JDDG — Tue, 17 Nov 2009 00:00:00 +0100

Leprosy is usually well-controlled by multidrug therapy (MDT). However, in case of noncompliance or leprosy reactions, it may present a therapeutically challenge. A 33-year-old Brazilian woman with lepromatous leprosy was treated with MDT for one year, but then discontinued therapy because she wanted to have children. Eight weeks after stopping her medications, she developed a severe and recalcitrant erythema (nodosum) leprosum (ENL) which presented histologically with thrombosed small veins and neutrophilic inflammation in fat septa, but without arteritis. During her pregnancy and ensuing lactation period, glucocorticoids were the only suitable drug. With the use of the shortened WHO/MDT regimen (one year vs. two years of treatment), ENL will probably be seen more often after the end of l...

Efracea 40mg Modified Release Capsules (doxycycline) - New formulation

NeLM - Dermatology — Tue, 17 Nov 2009 00:00:00 +0100

Source: MIMS Area: Other Library Updates > SPC Changes EFRACEA, a new formulation of doxycycline, is indicated to reduce papulopustular lesions in adult patients with facial rosacea. The daily dose is one 40 mg MR capsule in the morning. (Source: NeLM - Dermatology)

Dermoscopic rainbow pattern in non-Kaposi sarcoma lesions – reply

British Journal of Dermatology — Tue, 17 Nov 2009 00:00:00 +0100

(Source: British Journal of Dermatology)

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Superimposed Segmental Hemangioma of Infancy

Dermatology — Mon, 16 Nov 2009 23:00:00 +0100

Dermatology (DOI:10.1159/000259316) (Source: Dermatology)

Perifollicular White Halo: A Dermoscopic Subpattern of Melanocytic and Nonmelanocytic Skin Lesions [skINsight]

Archives of Dermatology — Mon, 16 Nov 2009 20:51:45 +0100

(Source: Archives of Dermatology)

Volunteering With Health Volunteers Overseas [Announcement]

Archives of Dermatology — Mon, 16 Nov 2009 20:51:45 +0100

(Source: Archives of Dermatology)

Cutaneous Epidermal Cysts as a Presentation of Gorlin Syndrome [Correspondence]

Archives of Dermatology — Mon, 16 Nov 2009 20:51:45 +0100

(Source: Archives of Dermatology)

Erosive Pustular Dermatosis of the Scalp Following Treatment With Topical Imiquimod for Actinic Keratosis [Correspondence]

Archives of Dermatology — Mon, 16 Nov 2009 20:51:45 +0100

(Source: Archives of Dermatology)

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An Association of Idiopathic Chronic Eosinophilic Pneumonia With Pemphigoid Nodularis: A Rare Variant of Bullous Pemphigoid [Correspondence]

Archives of Dermatology — Mon, 16 Nov 2009 20:51:45 +0100

(Source: Archives of Dermatology)

Leukonychia Related to Vorinostat [Correspondence]

Archives of Dermatology — Mon, 16 Nov 2009 20:51:45 +0100

(Source: Archives of Dermatology)

Linking Publication About Efalizumab Effectiveness With Safety Concerns [Correspondence]

Archives of Dermatology — Mon, 16 Nov 2009 20:51:45 +0100

(Source: Archives of Dermatology)

The Management of Severe Ocular Complications of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis--Reply [Correspondence]

Archives of Dermatology — Mon, 16 Nov 2009 20:51:45 +0100

(Source: Archives of Dermatology)

The Management of Severe Ocular Complications of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis [Correspondence]

Archives of Dermatology — Mon, 16 Nov 2009 20:51:45 +0100

(Source: Archives of Dermatology)

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No Biopsy Needed for Eclipse and Cockade Nevi Found on the Scalps of Children [Research Letters]

Archives of Dermatology — Mon, 16 Nov 2009 20:51:45 +0100

(Source: Archives of Dermatology)

Severe and Unrecognized Dental Abnormalities After Drug-Induced Epidermal Necrolysis [Research Letters]

Archives of Dermatology — Mon, 16 Nov 2009 20:51:45 +0100

(Source: Archives of Dermatology)

The Whiteboard Marker as a Useful Tool for the Dermoscopic "Furrow Ink Test" [Research Letters]

Archives of Dermatology — Mon, 16 Nov 2009 20:51:45 +0100

(Source: Archives of Dermatology)

Confluent Scaly Erythematous Plaques on the Trunk of a 16-Year-Old Boy--Diagnosis [Off-Center Fold]

Archives of Dermatology — Mon, 16 Nov 2009 20:51:45 +0100

(Source: Archives of Dermatology)

Confluent Scaly Erythematous Plaques on the Trunk of a 16-Year-Old Boy--Quiz Case [Off-Center Fold]

Archives of Dermatology — Mon, 16 Nov 2009 20:51:45 +0100

(Source: Archives of Dermatology)

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Asymptomatic Nodules on the Foot--Diagnosis [Off-Center Fold]

Archives of Dermatology — Mon, 16 Nov 2009 20:51:45 +0100

(Source: Archives of Dermatology)

Asymptomatic Nodules on the Foot--Quiz Case [Off-Center Fold]

Archives of Dermatology — Mon, 16 Nov 2009 20:51:45 +0100

(Source: Archives of Dermatology)

Fleshy Facial Lesion on an 80-Year-Old Dayak Woman--Diagnosis [Off-Center Fold]

Archives of Dermatology — Mon, 16 Nov 2009 20:51:45 +0100

(Source: Archives of Dermatology)

Fleshy Facial Lesion on an 80-Year-Old Dayak Woman--Quiz Case [Off-Center Fold]

Archives of Dermatology — Mon, 16 Nov 2009 20:51:45 +0100

(Source: Archives of Dermatology)

A Rapidly Growing Lesion on the Lip--Diagnosis [Off-Center Fold]

Archives of Dermatology — Mon, 16 Nov 2009 20:51:45 +0100

(Source: Archives of Dermatology)

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A Rapidly Growing Lesion on the Lip--Quiz Case [Off-Center Fold]

Archives of Dermatology — Mon, 16 Nov 2009 20:51:45 +0100

(Source: Archives of Dermatology)

Relevance of D-dimer Testing in Patients with Venous Malformations [Editorial]

Archives of Dermatology — Mon, 16 Nov 2009 20:51:45 +0100

(Source: Archives of Dermatology)

Adherence, the Fourth Dimension in the Geometry of Dermatological Treatment [Editorial]

Archives of Dermatology — Mon, 16 Nov 2009 20:51:44 +0100

(Source: Archives of Dermatology)

Disappearance of Lentigines in a Patient Receiving Imatinib Treatment for Familial Gastrointestinal Stromal Tumor Syndrome [Observation]

Archives of Dermatology — Mon, 16 Nov 2009 20:51:44 +0100

Conclusions The potential association between a specific genetic mutation and pigmentation changes secondary to imatinib therapy may account for the variety in presentation of this potential side effect. Further genetic studies paired with melanocyte-specific or c-kit–specific stains of affected tissue are warranted to better understand the relationship between the genetic mutation and the effect of imatinib on pigmentation. (Source: Archives of Dermatology)

Delayed Inflammatory Reaction to Bio-Alcamid Polyacrylamide Gel Used for Soft-Tissue Augmentation [Observation]

Archives of Dermatology — Mon, 16 Nov 2009 20:51:44 +0100

Conclusions Despite claims of safety, Bio-Alcamid and possibly other soft-tissue fillers available worldwide have the potential to cause adverse reactions. Physicians should be aware of the various presentations and treatment options for these reactions. (Source: Archives of Dermatology)

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The Balm of Gilead [Notable Notes]

Archives of Dermatology — Mon, 16 Nov 2009 20:51:44 +0100

(Source: Archives of Dermatology)

Pulsed High-Dose Corticosteroids Combined With Low-Dose Methotrexate Treatment in Patients With Refractory Generalized Extragenital Lichen Sclerosus [Observation]

Archives of Dermatology — Mon, 16 Nov 2009 20:51:44 +0100

Conclusions Patients with severe extragenital LS benefit from pulsed high-dose corticosteroids combined with low-dose methotrexate therapy. This combination therapy should be considered in generalized disease, especially disease that is refractory to conventional treatment. (Source: Archives of Dermatology)

Aquagenic Wrinkling of the Palms in Cystic Fibrosis: Comparison With Controls and Genotype-Phenotype Correlations [Observation]

Archives of Dermatology — Mon, 16 Nov 2009 20:51:44 +0100

Conclusions Our results confirm the association between AWP and CF. Among patients with CF, greater AWP occurs in those who are homozygous for the F508 mutation. (Source: Archives of Dermatology)

July 2009 Archives Web Quiz Winner [Archives Web Quiz Winner]

Archives of Dermatology — Mon, 16 Nov 2009 20:51:44 +0100

(Source: Archives of Dermatology)

Granulomatous Dermatitis With Pseudoxanthoma Elasticum-Like Changes: Report of a Case in a Patient With Cystic Fibrosis [Observation]

Archives of Dermatology — Mon, 16 Nov 2009 20:51:44 +0100

Conclusions There are few publications that document PXE-like changes in association with various inflammatory skin conditions. Thus, the clinical significance of this finding remains uncertain. This case and previous reports are discussed in the context of current molecular and genetic knowledge. It is hoped that greater awareness of this phenomenon will promote further investigation and elucidation of the clinical and biologic significance of PXE-like changes observed in biopsies of inflammatory skin disorders. (Source: Archives of Dermatology)

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Omitted Author Name in: Primary Treatment of Verrucous Carcinoma of the Penis With Fluorouracil, cis-Diamino-dichloro-platinum, and Radiation Therapy [Correction]

Archives of Dermatology — Mon, 16 Nov 2009 20:51:44 +0100

(Source: Archives of Dermatology)

Unexpected Occurrence of Xeroderma Pigmentosum in an Uncle and Nephew [Observation]

Archives of Dermatology — Mon, 16 Nov 2009 20:51:44 +0100

Conclusions Counseling families at risk for a rare inherited disease is not always straightforward. The sociocultural and demographic backgrounds of the families must be considered for evaluation of risk assessment. (Source: Archives of Dermatology)

Tumor Mapping in 2 Large Multigenerational Families With CYLD Mutations: Implications for Disease Management and Tumor Induction [Study]

Archives of Dermatology — Mon, 16 Nov 2009 20:51:44 +0100

Conclusions The burden of disease at sites other than the head and neck appears to be underreported in the literature and greatly affects quality of life. Differentiation between the clinical diagnoses has little prognostic or clinical utility in genetic counseling, even within individuals from the same family. Thus, we suggest an encompassing diagnosis of "CYLD cutaneous syndrome." Finally, the clinical distribution of tumors suggests that hormonal factors may play an important role in tumor induction in these patients. (Source: Archives of Dermatology)

Topical Calcipotriol for Preventive Treatment of Hypertrophic Scars: A Randomized, Double-blind, Placebo-Controlled Trial [Study]

Archives of Dermatology — Mon, 16 Nov 2009 20:51:44 +0100

Conclusions Topical application of calcipotriol during the first 3 months of wound healing does not affect the incidence of hypertrophic scar formation. We observed a strong association between keratinocyte activation and hypertrophic scar formation. Trial Registration trialregister.nl Identifier: NTR1486 (Source: Archives of Dermatology)

Alefacept for Severe Alopecia Areata: A Randomized, Double-blind, Placebo-Controlled Study [Study]

Archives of Dermatology — Mon, 16 Nov 2009 20:51:44 +0100

Conclusion Alefacept is ineffective for the treatment of severe AA. (Source: Archives of Dermatology)

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Factors Contributing to Incomplete Excision of Nonmelanoma Skin Cancer by Australian General Practitioners [Study]

Archives of Dermatology — Mon, 16 Nov 2009 20:51:44 +0100

Conclusions Overall frequency of incomplete excision is low and similar to that in other reports. However, high frequency in high-risk sites, low rates of previous biopsy, and substantial variation in performance between physicians and clinics suggests there is significant opportunity to further improve health outcomes. (Source: Archives of Dermatology)

August 2009 Archives Web Quiz Winner [Archives Web Quiz Winner]

Archives of Dermatology — Mon, 16 Nov 2009 20:51:44 +0100

(Source: Archives of Dermatology)

Analysis of Globule Types in Malignant Melanoma [Study]

Archives of Dermatology — Mon, 16 Nov 2009 20:51:44 +0100

Conclusions The presence of globules of varying size or shape seems to be more associated with a diagnosis of malignant melanoma than any other globule type or distribution in this study. Large globules are of particular importance in the diagnosis of malignant melanoma. (Source: Archives of Dermatology)

Elevated D-dimer Level in the Differential Diagnosis of Venous Malformations [Study]

Archives of Dermatology — Mon, 16 Nov 2009 20:51:44 +0100

Conclusions Elevated D-dimer level is highly specific for VMs (pure, combined, or syndromic), and therefore this easy and inexpensive biomarker test should become part of the clinical evaluation of vascular anomalies. It can detect hidden VMs and help differentiate glomuvenous malformation (normal D-dimer levels) from other multifocal venous lesions. Elevated D-dimer level also differentiates a VM from a lymphatic malformation. Moreover, slow-flow Klippel-Trenaunay syndrome (capillaro-lymphatico-venous malformation with limb hypertrophy) can be distinguished from fast-flow Parkes Weber syndrome (capillary malformation with underlying multiple microfistulas and limb hypertrophy). For these reasons, D-dimer level measurement is a useful complementary tool for diagnosing vascular anomal...

Text-Message Reminders to Improve Sunscreen Use: A Randomized, Controlled Trial Using Electronic Monitoring [Study]

Archives of Dermatology — Mon, 16 Nov 2009 20:51:44 +0100

Conclusions Despite awareness of the benefits of sunscreen, adherence is low, even in this population, for whom adherence was knowingly monitored. Short-term data demonstrate that using existing cellular telephone text-message technology offers an innovative, low-cost, and effective method of improving adherence to sunscreen application. The use of ubiquitous communications technology, such as text messaging, may have implications for large-scale public health initiatives. Trial Registration clinicaltrials.gov Identifier: NCT00535769 (Source: Archives of Dermatology)

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Leflunomide in the Treatment of Palmoplantar Pustulosis [The Cutting Edge]

Archives of Dermatology — Mon, 16 Nov 2009 20:51:44 +0100

(Source: Archives of Dermatology)

Idiopathic Multiple Haemorrhagic Sarcoma (Kaposi): Trauma an Aetiological Factor (?) [Archives a Century Ago]

Archives of Dermatology — Mon, 16 Nov 2009 20:51:44 +0100

(Source: Archives of Dermatology)

This Month in Archives of Dermatology [This Month in Archives of Dermatology]

Archives of Dermatology — Mon, 16 Nov 2009 20:51:44 +0100

(Source: Archives of Dermatology)

About This Journal [About This Journal]

Archives of Dermatology — Mon, 16 Nov 2009 20:51:44 +0100

(Source: Archives of Dermatology)

What Is Dupuytren's Contracture? What Cause Dupuytren's Contracture?

Dermatology News From Medical News Today — Mon, 16 Nov 2009 14:00:00 +0100

Dupuytren's contracture (Dupuytren contracture) is a condition that affects the hands and fingers. It is an uncommon hand deformity in which the connective tissue under the skin of the palm contract and toughen over time. It causes one or more of the fingers on one or both hands to bend into the palm of the hand. Dupuytren's contracture is named after the French surgeon, Baron Guillaume Dupuytren, who first described and researched the condition in 1834. (Source: Dermatology News From Medical News Today)

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Child Food Allergies on the Rise in U.S.

MedicineNet Skin General — Mon, 16 Nov 2009 07:00:00 +0100

Title: Child Food Allergies on the Rise in U.S.Category: Health NewsCreated: 11/16/2009 8:10:00 AMLast Editorial Review: 11/16/2009 (Source: MedicineNet Skin General)

Tapping Into Curry's Health Benefits

MedicineNet Skin General — Mon, 16 Nov 2009 07:00:00 +0100

Title: Tapping Into Curry's Health BenefitsCategory: Health NewsCreated: 11/13/2009 4:10:00 PMLast Editorial Review: 11/16/2009 (Source: MedicineNet Skin General)

Uncertainties Page: Should we use bath emollients for atopic eczema?

NeLM - Dermatology — Mon, 16 Nov 2009 00:00:00 +0100

Source: BMJ Area: News The authors of this article discuss the uncertainties surrounding the use of bath emollients as part of the treatment of atopic eczema, which the NHS in England spent around £15.5m on in 2008. They were unable to identify any published RCTs assessing the clinical efficacy of bath emollients in atopic eczema from a search of the literature. In addition they state that they are not aware of any longstanding clinical experience of benefit from bath emollients to match that for directly applied emollients, and that the quantities of emollient deposited on the skin during bathing are likely to be far lower than with directly applied emollients. They conclude that "based on current evidence, bath emollients could be offering little or no bene...

Consider underlying body dysmorphic disorder in users of melanotan

British Journal of Dermatology — Mon, 16 Nov 2009 00:00:00 +0100

(Source: British Journal of Dermatology)

Using 'number needed to treat' to express the magnitudes of benefit of ultraviolet B phototherapy and of antitumour necrosis factor-α therapies for psoriasis

British Journal of Dermatology — Mon, 16 Nov 2009 00:00:00 +0100

(Source: British Journal of Dermatology)

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Iatrogenic melanoma. Comment on: Melanoma epidemic: a midsummer night's dream?

British Journal of Dermatology — Mon, 16 Nov 2009 00:00:00 +0100

(Source: British Journal of Dermatology)

BRAF V600E mutation and the tumour suppressor IGFBP7 in atypical genital naevi

British Journal of Dermatology — Mon, 16 Nov 2009 00:00:00 +0100

Conclusions The prevalence of BRAF V600E in AGN suggests that ultraviolet exposure is not essential for generating the mutation. The BRAF V600E mutational status appears to be of limited diagnostic utility in distinguishing genital naevi that exhibit atypia from those that do not. Similar to oncogenic BRAF-positive common naevi without atypia, enhanced expression of the tumour suppressor IGFBP7 in oncogenic BRAF-positive AGN supports that they are biologically inert. (Source: British Journal of Dermatology)

A survey of sun protection in schools in South Wales

British Journal of Dermatology — Mon, 16 Nov 2009 00:00:00 +0100

(Source: British Journal of Dermatology)

Author Index Vol. 22, 2009

Skin Pharmacology and Physiology — Sun, 15 Nov 2009 23:00:00 +0100

Skin Pharmacol Physiol 2009;22:335-336 (DOI:10.1159/000260054) (Source: Skin Pharmacology and Physiology)

Subject Index Vol. 22, 2009

Skin Pharmacology and Physiology — Sun, 15 Nov 2009 23:00:00 +0100

Skin Pharmacol Physiol 2009;22:337-338 (DOI:10.1159/000260055) (Source: Skin Pharmacology and Physiology)

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Contents Vol. 22, 2009

Skin Pharmacology and Physiology — Sun, 15 Nov 2009 23:00:00 +0100

Skin Pharmacol Physiol 2009;22:I-IV (DOI:10.1159/000260056) (Source: Skin Pharmacology and Physiology)

Psoriasis treatment guidelines proposed for patients with concomitant HCV

MedWire News - Psoriasis — Sat, 14 Nov 2009 14:03:31 +0100

Topical therapy and ultraviolet B phototherapy should be considered first-line and second-line therapies for patients with limited psoriasis and concomitant hepatitis C virus infection, suggests a consensus report from the Medical Board of the US National Psoriasis Foundation. (Source: MedWire News - Psoriasis)

Psoriasis treatment guidelines proposed for patients with concomitant HCV

MedWire News - Dermatology — Sat, 14 Nov 2009 14:03:31 +0100

Effectiveness of Pulsed Dye Laser in the Treatment of Recalcitrant Warts in Children

Dermatologic Surgery — Sat, 14 Nov 2009 00:00:00 +0100

To determine the efficacy and safety of the 585-nm pulsed dye laser (PDL) in the treatment of recalcitrant warts in children. Retrospective survey of the medical records of children with recalcitrant warts who were treated with PDL between March 1995 through January 1999 at the Children's Memorial Hospital outpatient subspecialty center, Chicago, Illinois. Sixty-one children with recalcitrant warts were treated with PDL; 75% of them had total clearance of warts after an average of 3.1 treatment sessions. Overall success rates were 100% for both perineal and perianal and face-only warts, 93% for hands, 69% for plantar warts, 67% when both face and extremities were involved, and 60% when multiple extremities were involved. Pain and other side effects were minimal. Mild scarring occurred in 2...

Satisfying patient expectations with soft-tissue augmentation.

Dermatol Online J — Fri, 13 Nov 2009 12:06:04 +0100

This article suggests a series of steps to help determine the most appropriate approach for volume restoration with injectable devices for satisfying patient treatment expectations. PMID: 19903429 [PubMed - in process] (Source: Dermatol Online J)

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Nail disease in pemphigus vulgaris.

Dermatol Online J — Fri, 13 Nov 2009 12:06:04 +0100

Authors: Serratos BD, Rashid RM Patients affected by pemphigus vulgaris will occasionally present with associated and characteristic nail changes. This manuscript was prepared as a review of this unique presentation of pemphigus. Articles describing pemphigus vulgaris of the nail were compiled and reviewed and pertinent information was extracted to provide a concise analysis. The literature on this topic is still maturing. Publications to date suggest the incidence of nail and periungal involvement may correlate with the severity of mucocutaneous symptoms and the duration of the disease. The most common nail manifestations reported were acute or chronic paronychia and onychomadesis, and involvement of the fingernails. The nail changes may precede or develop concurrently with the mucocu...

Pioderma gangrenoso - Abordagem clínica, laboratorial e terapêutica: Revisão de 28 casos.

Dermatol Online J — Fri, 13 Nov 2009 12:06:04 +0100

We present a retrospective study of 28 patients, admitted to Hospital de São João, EPE, between January of 1990 and June of 2008. Pyoderma gangrenosum was observed more frequently in middle age adults, in the ulcerated form, and predominantly localized in the lower limbs. Pediatric presentation was very rare. In 50 percent of these cases a systemic disease was present and the most frequent was Crohn disease (14% of patients). PMID: 19903431 [PubMed - in process] (Source: Dermatol Online J)

Advice for medical students interested in dermatology: Perspectives from fourth year students who matched.

Dermatol Online J — Fri, 13 Nov 2009 12:06:04 +0100

We present perspectives from four fourth year medical students who matched into dermatology that highlight the factors they believed helped them most. The purpose is to offer advice to medical students interested in dermatology. We divide the paper into four areas of discussion: academics, extracurricular activities, research, and mentorship. All four factors are crucial for a strong dermatology application. We believe the paper provides valuable suggestions and guidance to students considering a career in dermatology. PMID: 19903432 [PubMed - in process] (Source: Dermatol Online J)

A case of bullous disease limited to the skin illustrates the spectrum of neoplasia induced autoimmunity.

Dermatol Online J — Fri, 13 Nov 2009 12:06:04 +0100

We describe a patient with fatal autoimmune blistering disease with absence of mucous membrane lesions. The pattern of complement indirect immunofluoresence helped identify the prognosis prospectively. This case illustrates yet another presentation of the neoplasia-induced autoimmunity. PMID: 19903433 [PubMed - in process] (Source: Dermatol Online J)

A case of primary cutaneous B cell lymphoma of the knee.

Dermatol Online J — Fri, 13 Nov 2009 12:06:04 +0100

We report the case of a gentleman with a primary cutaneous B cell lymphoma of the leg who underwent an amputation and later died. This is an uncommon type of cutaneous lymphoma with poor prognosis and the case demonstrates how aggressive the tumor can become. PMID: 19903434 [PubMed - in process] (Source: Dermatol Online J)

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Pseudoxanthoma elasticum-like syndrome and thalassemia: An update.

Dermatol Online J — Fri, 13 Nov 2009 12:06:04 +0100

We describe three cases of the acquired PXE-like syndrome that often occurs in association with hemolytic anemias, in particular the hemoglobinopathies, and review the literature on the subject. The pathogenesis of the acquired PXE-like lesions is not yet completely understood. None of the mutations observed in the inherited form has been detected in the syndrome accompanying thalassemia. The cardiovascular complications could be life-threatening. Therefore, an close surveillance of these patients is mandatory. PMID: 19903435 [PubMed - in process] (Source: Dermatol Online J)

Mucoceles not - Oral cysticercosis and minor salivary gland adenocarcinoma: Two case reports.

Dermatol Online J — Fri, 13 Nov 2009 12:06:04 +0100

We present two cases that were clinically diagnosed as mucoceles that were removed because of patient anxiety. However, histological examination revealed dissimilar and medically significant pathologies. Oral cysticercosis and salivary gland adenocarcinoma are rare diseases of the oral mucosa. It is important to consider these and other uncommon diagnoses when evaluating an oral nodule presumed to be a mucocele. We will discuss the natural history and pathogenesis of these disease processes. PMID: 19903436 [PubMed - in process] (Source: Dermatol Online J)

Keratoacanthoma in a tattoo.

Dermatol Online J — Fri, 13 Nov 2009 12:06:04 +0100

We report a keratoacanthoma arising in a recent tattoo. A 60-year-old woman presented with a tumor on her right leg, over an area of red pigment in a professional tattoo. Histological analysis confirmed the clinical diagnosis of keratoacanthoma. Although the association between malignancy and tattoos is very uncommon dermatologists and dermatologic surgeons should be attentive to this possibility. PMID: 19903437 [PubMed - in process] (Source: Dermatol Online J)

A remarkable case of cutaneous metastatic breast carcinoma.

Dermatol Online J — Fri, 13 Nov 2009 12:06:04 +0100

We describe a 50-year-old woman with a 5-month history of multiple asymptomatic papulonodular lesions on the left chest area. Biopsy was consistent with cutaneous metastases from a ductal breast carcinoma. No distant metastatic lesions were detected. The patient was referred to the Gynecologic Oncology Department. Treatment included chemotherapy, radiotherapy and surgery. At present the patient is well with no signs of recurrence. This case reports a clinically remarkable cutaneous metastatic breast carcinoma. PMID: 19903438 [PubMed - in process] (Source: Dermatol Online J)

MedWorm: Dermatology

Burns Patients Awaiting Skin Grafts: Human Embryonic Stem-Cells Could Be Used To Generate Temporary Skin

Is the Dermatology Life Quality Index really time-sensitive?

Birt–Hogg–Dubé syndrome: clinical and genetic studies of 10 French families

Instructions for Category 1 CME Credit

Information for Readers

Table of Contents

Editorial Board

November iotaderma (#190)

Iotaderma #191

Subject index

Author index

Cover Sheet for Index

Dermatology Calendar

Life with epidermolysis bullosa (EB): Etiology, diagnosis, multidisciplinary care and therapy

Requisites in dermatology: General dermatology

Circumscribed palmar hypokeratosis

Congenital dacryocystocele

Persistent agmination of lymphomatoid papulosis evolving to classical lesions of lymphomatoid papulosis

Radiation recall dermatitis induced by erlotinib

Videodermatoscopy enhances diagnostic capability in psoriatic balanitis

Patient preferences for dermatology visits

Reporting clinical trials: Why one plus one does not equal two

Physiologic changes in vascular birthmarks during early infancy: Mechanisms and clinical implications

Nonmelanoma skin cancer in vitiligo patients

Tinea capitis treatment in Spain

Freedom of expression or protectionism in the debate on sentinel node biopsy in melanoma

Volunteers Needed

Correction

Correction

Immunomodulatory therapy of cutaneous T-cell lymphoma: A multimodality approach in advanced disease

Pain associated with aminolevulinic acid-photodynamic therapy of skin disease

Initial presentation of stasis dermatitis mimicking solitary lesions: A previously unrecognized clinical scenario

Microscopically differentiating dermatophytes from sock fibers

Surgical management of congenital dermatofibrosarcoma protuberans

Change of Address

Answers to CME examination

CME examination

Earn CME and MOC Credits Through a New Online e-Blue Feature

Angiogenesis in cutaneous disease: Part II

American Board of Dermatology Examination Dates

Answers to CME examination

CME examination

Angiogenesis in cutaneous disease: Part I

Prognostic factors for cure following treatment of onychomycosis

Tissue and blood superoxide dismutase activity and malondialdehyde level in leprosy

Multiple trichoepitheliomas – a novel mutation in the CYLD gene

Efficacy of narrowband UVB vs. PUVA in patients with early-stage mycosis fungoides

Sarcoidosis and sarcoid-like pathologies of the skin: result of a common pathological (immunodeficiency) process? – Authors' reply to the comment of Dr Luis Ignacio Gonzalez-Granado

The impact of obesity on skin disease and epidermal permeability barrier status

No association between nickel allergy and reporting cosmetic dermatitis from mascara or eye shadow: a cross-sectional general population study

Cetuximab-induced cutaneous toxicity

A simple assay for the study of human hair follicle damage induced by ionizing irradiation

Impact of Adalimumab on Symptoms of Psoriatic Arthritis in Patients with Moderate to Severe Psoriasis: A Pooled Analysis of Randomized Clinical Trials

FDA Approves New Drug For Pain That Persists After Shingles

Basilea's Toctino(R) Receives Marketing Authorization In Canada

New Study Ushers In Spring-Time For Slow Inactivation

TAU Develops Dissolving Dressing For Wounds Packed With Infection-Fighting Antibiotics

University Of Montreal Study Reveals Danger To Fetus Of Certain Drugs

International Psoriasis Council Hosts Second Educational Symposium To Increase Global Knowledge Of Psoriasis

Qutenza Approved for Post-Shingles Nerve Pain

Tween: Child Development

Skin fragility and blistering with imatinib mesylate

Notalgia paresthesica successfully treated with narrow-band UVB: report of five cases

Porokeratotic eccrine ostial and dermal duct naevus: report of 10 cases

Humoral deficiencies as an underlying cause of sarcoidosis of the skin

The mineralocorticoid receptor as a novel player in skin biology: beyond the renal horizon?

Drug-induced angioedema without urticaria: prevalence and clinical features

Can blood components with age-related changes influence the ageing of endothelial cells?

Remission of extensive intrahepatic metastasis by C-arm computed tomography guided chemoembolization in uveal melanoma

'Wear Ur SPF' Text Reminders Increase Sunscreen Use (CME/CE)

Innovative Strategy Could Help People Follow Doctors' Orders, Take Medications

Skin Color Gives Clues To Health

Health Tip: When Baby Is Teething

CKS topic review: Chilblains

Plasmacytoid dendritic cell neoplasm treated successfully with rituximab

Quality of life and health-related utility analysis of adults with moderate and severe atopic dermatitis treated with tacrolimus ointment vs. topical corticosteroids

Angiokeratoma regression in a Fabry disease after treatment with agalsidase-β: clinical effectiveness marker?

Microalbuminuria as an early marker of renal involvement in Behcet's disease: it is associated with neurological involvement and duration of the disease

Erythema leprosum – after treatment of Lepromatous Leprosy