MedWorm: Drugs & Pharmacology

Administration of Caffeic Acid Worsened Bone Mechanical Properties in Female Rats

Planta Medica — Sat, 21 Nov 2009 14:03:56 +0100

In conclusion, high intake of caffeic acid may unfavorably affect the skeletal system.[...]© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Abstract | Full text (Source: Planta Medica)

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Intestinal and Blood-Brain Barrier Permeability of Ginkgolides and Bilobalide: In Vitro and In Vivo Approaches

Planta Medica — Sat, 21 Nov 2009 14:03:56 +0100

In this study intestinal and blood-brain barrier (BBB) permeability of ginkgolides A, B, C, J and bilobalide, isolated from (Ginkgoaceae), was evaluated in Caco-2 and MDR1-MDCK cell monolayer models. The transport was examined for 2 hours in both absorptive and secretory directions. Quantitation was performed by UPLC‐MS. In the Caco-2 model, each compound (100 µM) displayed a pH-dependent transport in the absorptive direction. A low permeability of ginkgolides was observed across the MDR1-MDCK model in the absorptive direction. An efflux was observed for all compounds in both the models. The efflux ratio was much higher in the MDR1-MDCK cell model (> 10) compared to the Caco-2 cell model (1.5–3.6). In comparison to ginkgolides, the permeability of bilobalide was...

Cytotoxicity of Natural Compounds Isolated from the Seeds of Garcinia afzelii

Planta Medica — Sat, 21 Nov 2009 14:03:56 +0100

Planta MedDOI: 10.1055/s-0029-1240627AbstractThe new compounds guttiferone O () and 3-methoxycheffouxanthone () have been isolated from the seeds of Engl., together with nine known compounds: 2-hydroxy-1,7-dimethoxyxanthone (), smeathxanthone A (), 1,5-dihydroxyxanthone (), 1,6-dihydroxy-5-methoxyxanthone (), cheffouxanthone (), 1,3,5-trihydroxyxanthone (), smeathxanthone B (), isoxanthochymol () and guttiferone E (). Their structures were elucidated by means of 1D and 2D‐NMR techniques. All the isolates showed high cytotoxic activity and were found inactive when tested against HIV and influenza viruses.[...]© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Abstract | Full text (Source: Planta Medica)

Minor Secondary Metabolic Products from the Stem Bark of Plumeria rubra Linn. Displaying Antimicrobial Activities

Planta Medica — Sat, 21 Nov 2009 14:03:56 +0100

Planta MedDOI: 10.1055/s-0029-1240611AbstractFour new iridoids viz., plumeridoids A (), B (), and C () and epiplumeridoid C () were isolated from the stem bark of Linn. together with twenty-four known compounds viz., 1-(-hydroxyphenyl)propan-1-one, isoplumericin, plumericin, dihydroplumericin, allamcin, fulvoplumerin, allamandin, plumieride, --coumaric acid, 2,6-dimethoxy--benzoquinone, scopoletin, cycloart-25-en-3,24-diol, 2,4,6-trimethoxyaniline, ajunolic acid, ursolic acid, oleanolic acid, -amyrin acetate, betulinic acid, lupeol and its acetate, 2,3-dihydroxypropyl octacosanoate, glucoside of -sitosterol, and a mixture of common sterols (stigmasterol and -sitosterol). Their structures were determined by means of spectroscopic data including HREIMS, H NMR, C NMR, 2D NMR (HMQC, HMBC...

Effects of α-Asarone on the Glutamate Transporter EAAC1 in Xenopus Oocytes

Planta Medica — Sat, 21 Nov 2009 14:03:56 +0100

Planta MedDOI: 10.1055/s-0029-1240613AbstractThe major excitatory neurotransmitter transporter EAAC1 in the mammalian central nervous system is considered a possible target for Chinese herbal medicine. Extracts of (Schott) were tested for their effects on EAAC1 activity. oocytes with heterologously expressed EAAC1 were used as the model system. Rate of glutamate uptake was determined by means of the isotopic tracer technique. Glutamate-induced current was recorded under a two-electrode voltage clamp. As a highly effective component, -asarone was identified. The rate of glutamate uptake was stimulated by 200 µM of -asarone by about 15 %. In contrast, the same concentration reduced the EAAC1-mediated current by about 35 % at a holding potential of − 60 mV...

The Corrected Structure of Rosmaridiphenol, a Bioactive Diterpene from Rosmarinus officinalis

Planta Medica — Sat, 21 Nov 2009 14:03:56 +0100

Planta MedDOI: 10.1055/s-0029-1240629AbstractFrom the aerial parts of a Chilean sample of L., a diterpene was isolated whose spectroscopic data and physical constants were coincident with that of rosmaridiphenol. However, careful examination of the spectroscopic data and chemical reactions led to a different structure, where the carbonyl function has to be placed at C-1 instead of C-20. The correct structure of rosmaridiphenol should therefore be changed to 11,12-dihydroxy-8,11,13-icetexatrien-1-one.[...]© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Abstract | Full text (Source: Planta Medica)

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New Phenolic Compounds of Acmella ciliata

Planta Medica — Sat, 21 Nov 2009 14:03:56 +0100

Planta MedDOI: 10.1055/s-0029-1240621AbstractThe phytochemical analysis of a butanolic fraction of Kunth. afforded a total of 15 hydrophilic compounds. Seven flavonol 3--glycosides were isolated, including two new natural products, quercetin-3--(3-acetyl--D-glucuronopyranoside) and quercetin-3--(2-acetyl--L-rhamnopyranosyl-(1 → 6)--D-glucopyranoside). Furthermore, a variety of caffeoylquinic acid derivatives could be identified using ESI‐MS and NMR-spectroscopy.[...]© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Abstract | Full text (Source: Planta Medica)

Green Tea Catechins: Inhibitors of Glycerol-3-Phosphate Dehydrogenase

Planta Medica — Sat, 21 Nov 2009 14:03:56 +0100

Planta MedDOI: 10.1055/s-0029-1240623AbstractGreen tea catechins, especially (−)-epigallocatechin-3-gallate (EGCG), are known to regulate obesity and fat accumulation. We performed a kinetic analysis in a cell-free system to determine the mode of inhibition of glycerol-3-phosphate dehydrogenase (GPDH; EC 1.1.1.8) by EGCG. GPDH catalyzes the -nicotinamide adenine dinucleotide (NADH)-dependent reduction of dihydroxyacetone phosphate (DHAP) to yield glycerol-3-phosphate, which serves as one of the major precursors of triacylglycerols. We found that EGCG dose-dependently inhibited GPDH activity at a concentration of approximately 20 μM for 50 % inhibition. The IC values of other green tea catechins, such as (−)-epicatechin, (−)-epicatechin-3-gallate, and (...

SERTRALINE HYDROCHLORIDEsolution, Concentrate [Aurobindo Pharma Limited]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Sat, 21 Nov 2009 14:00:07 +0100

Updated Date: Nov 19, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

US could ban caffeine-alcohol drinks within months

New Scientist - Drugs and Alcohol — Sat, 21 Nov 2009 13:44:53 +0100

The US Food and Drug Administration has asked manufacturers of drinks that combine alcohol and caffeine to provide scientific evidence they are safe (Source: New Scientist - Drugs and Alcohol)

Semi-Synthesis of Dihydrochalcone Derivatives and Their in Vitro Antimicrobial Activities

Planta Medica — Sat, 21 Nov 2009 03:03:02 +0100

We describe the semi-synthesis of dihydrochalcone derivatives and their antimicrobial activities. These compounds were prepared by modifying two naturally occurring antimicrobial dihydrochalcones, erioschalcones A and B, reported by us earlier. The structures of the compounds were assigned on the basis of spectroscopic evidence and by comparing their physical and spectroscopic data with those reported in the literature. All the compounds were subjected to antimicrobial assays against a panel of pathogenic microorganisms, including gram-positive and gram-negative bacteria, and fungi. The antimicrobial efficacies of this class of compounds were established by correlating the activity profile of each compound with its structure and by comparing the activities of all the compounds with each ot...

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Assessing the Impact of Efalizumab on Nail, Scalp and Palmoplantar Psoriasis and on Quality of Life: Results from a Multicentre, Open-label, Phase IIIb/IV Trial

Archives of Drug Information — Sat, 21 Nov 2009 00:00:00 +0100

This post-approval, open-label trial (n = 1266) assessed the efficacy of efalizumab, administered in accordance with the European label at that time, in patients with concomitant nail, scalp or palmoplantar psoriasis. Patients received subcutaneous efalizumab 1.0 mg/kg weekly for up to 20 weeks. By Week 12, an improvement from baseline of 50% or more was observed in 21.4% (181/844) of patients with nail psoriasis, 62.4% (718/1150) of patients with scalp psoriasis, and 51.4% (127/247) of patients with palmoplantar psoriasis. Quality of life improved throughout the trial, with a 50% median improvement in DLQI score after 12 weeks of treatment. Efalizumab showed promising efficacy in the treatment of nail, scalp and palmoplantar psoriasis, which was reflected in improvements in quality of lif...

Joint Commission updates National Patient Safety Goals for 2010.

American Journal of Health-System Pharmacy : AJHP — Fri, 20 Nov 2009 21:36:40 +0100

Authors: Traynor K PMID: 19923302 [PubMed - as supplied by publisher] (Source: American Journal of Health-System Pharmacy : AJHP)

Ofatumumab approved for advanced CLL.

American Journal of Health-System Pharmacy : AJHP — Fri, 20 Nov 2009 21:36:37 +0100

Authors: Traynor K PMID: 19923303 [PubMed - as supplied by publisher] (Source: American Journal of Health-System Pharmacy : AJHP)

Health system views pharmacist as vital to coordinated care.

American Journal of Health-System Pharmacy : AJHP — Fri, 20 Nov 2009 21:36:34 +0100

Authors: Thompson CA PMID: 19923304 [PubMed - as supplied by publisher] (Source: American Journal of Health-System Pharmacy : AJHP)

Some unused narcotics should go down the drain, FDA says.

American Journal of Health-System Pharmacy : AJHP — Fri, 20 Nov 2009 21:36:31 +0100

Authors: Traynor K PMID: 19923305 [PubMed - as supplied by publisher] (Source: American Journal of Health-System Pharmacy : AJHP)

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International hospital pharmacy section reorganizes to promote Basel Statements.

American Journal of Health-System Pharmacy : AJHP — Fri, 20 Nov 2009 21:36:28 +0100

Authors: Thompson CA PMID: 19923306 [PubMed - as supplied by publisher] (Source: American Journal of Health-System Pharmacy : AJHP)

Development of a methadone order form for inpatients.

American Journal of Health-System Pharmacy : AJHP — Fri, 20 Nov 2009 21:36:25 +0100

Authors: McMillian WD, Gencarelli SC PMID: 19923307 [PubMed - as supplied by publisher] (Source: American Journal of Health-System Pharmacy : AJHP)

Leading from a staff or clinical position.

American Journal of Health-System Pharmacy : AJHP — Fri, 20 Nov 2009 21:36:22 +0100

Authors: White SJ PMID: 19923308 [PubMed - as supplied by publisher] (Source: American Journal of Health-System Pharmacy : AJHP)

Alert fatigue.

American Journal of Health-System Pharmacy : AJHP — Fri, 20 Nov 2009 21:36:19 +0100

Authors: Cash JJ PMID: 19923309 [PubMed - as supplied by publisher] (Source: American Journal of Health-System Pharmacy : AJHP)

The dilemma of establishing effective pharmacy staffing levels.

American Journal of Health-System Pharmacy : AJHP — Fri, 20 Nov 2009 21:36:16 +0100

Authors: Shane R, Gouveia W PMID: 19923310 [PubMed - as supplied by publisher] (Source: American Journal of Health-System Pharmacy : AJHP)

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Clinical and economic value of screening for Kras mutations as predictors of response to epidermal growth factor receptor inhibitors.

American Journal of Health-System Pharmacy : AJHP — Fri, 20 Nov 2009 21:36:13 +0100

CONCLUSION: Mutations in the Kras oncogene are associated with a poor response to EGFR inhibitor therapy in metastatic colorectal cancer. Implementing routine Kras screening and limiting the use of EGFR inhibitors to patients with wild-type (not mutated) Kras may have the potential for cost savings. PMID: 19923311 [PubMed - as supplied by publisher] (Source: American Journal of Health-System Pharmacy : AJHP)

Review of recent evidence: Potential interaction between clopidogrel and proton pump inhibitors.

American Journal of Health-System Pharmacy : AJHP — Fri, 20 Nov 2009 21:36:11 +0100

CONCLUSION: Although data are limited, observational studies and prospective trials involving surrogate markers of platelet reactivity suggest a clinically significant interaction between clopidogrel and PPIs. Until further studies are completed to delineate the specifics of the interaction between clopidogrel and PPIs, the risks and benefits of concomitant treatment should be carefully weighed to determine the most appropriate treatment for each individual patient. PMID: 19923312 [PubMed - as supplied by publisher] (Source: American Journal of Health-System Pharmacy : AJHP)

Elevated International Normalized Ratio associated with concurrent use of sorafenib and warfarin.

American Journal of Health-System Pharmacy : AJHP — Fri, 20 Nov 2009 21:36:08 +0100

CONCLUSION: A 70-year-old man diagnosed with hepatocellular carcinoma experienced an increase in INR values after the addition of sorafenib to his warfarin regimen. PMID: 19923313 [PubMed - as supplied by publisher] (Source: American Journal of Health-System Pharmacy : AJHP)

Medication reconciliation at an academic medical center: Implementation of a comprehensive program from admission to discharge.

American Journal of Health-System Pharmacy : AJHP — Fri, 20 Nov 2009 21:36:05 +0100

CONCLUSION: A pharmacy-driven multidisciplinary admission history and medication reconciliation process has reduced medication errors in an academic medical center. PMID: 19923314 [PubMed - as supplied by publisher] (Source: American Journal of Health-System Pharmacy : AJHP)

Synthesis and biological activities of new substituted thiazoline-quinoline derivatives.

Acta Pharmaceutica — Fri, 20 Nov 2009 21:28:28 +0100

Authors: Hussein MA, Kafafy AH, Abdel-Moty SG, Abou-Ghadir OM 5-Acyl-8-hydroxyquinoline-2-(3'-substituted-4'-aryl-2,3-dihydrothiazol-2'-ylidene)hydrazones, 5a-e to 10a-c, were prepared by the reaction of appropriate 5-acyl-8-hydroxyquinoline-4-substituted thiosemicarbazones 3a-e and phenacyl bromides 4a-e. Structures of the new compounds were verified on the basis of spectral and elemental analyses. Twenty-eight new compounds were tested for their possible antimicrobial activities. Most of the tested compounds showed weak to moderate antibacterial activity against most of the bacterial strains used in comparison with gatifloxacin as a reference drug. The test compounds showed weak to moderate antifungal activity against tested fungi in comparison with ketoconazole as a reference drug. ...

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Formulation and evaluation of monolithic matrix polymer films for transdermal delivery of nitrendipine.

Acta Pharmaceutica — Fri, 20 Nov 2009 21:28:26 +0100

The objective of the present work was to develop a suitable transdermal drug delivery system for nitrendipine. Polymeric films of nitrendipine were prepared by the film casting technique (glass ring) on mercury substrate. They were evaluated for physicochemical parameters, in vitro release and ex vivo permeation (heat separated human epidermis). Release of the drug from the films followed anomalous transport (0.5 < n < 1).Polymeric combination containing Eudragit RL 100:PVP K 30 in a 4:6 ratio showed the best results. Maximum drug release and skin permeability coefficient in 48 h were 85.8% and 0.0142 cm h-1, respectively, in formulation C3 (Eudragit RL 100/Plasdone S 630; 4:6) and 88.0% and 0.0155 cm h-1, respectively, in formulation, D3 (Eudragit RL 100/PVP K 30; 4:6). FTIR and TLC...

Permeation of losartan across human respiratory epithelium: An in vitro study with Calu-3 cells.

Acta Pharmaceutica — Fri, 20 Nov 2009 21:28:24 +0100

Authors: Amoako-Tuffour M, Yeung PK, Agu RU The potential for nasal delivery of losartan, a drug with poor oral bioavailability, was investigated using Calu-3 cells. Epithelial permeation of the drug with or without dimethyl-beta-cyclodextrin (DM-beta-CD) and glycocholate was investigated. Possible transport mechanism of the compound and epithelial mucosal tolerance were screened. Reversibility of epithelial membrane perturbation was also investigated by measuring transepithelial electrical resistance (TEER) recovery over a 24-h period following drug formulation exposure. The permeability coefficient of losartan was 1.3 +/- 0.5 x 10-6 cm s-1. This flux was not significantly different from that of formulations containing DM-beta-CD (0.5 and 1.0%) or glycocholate (0.5%). However, the for...

A new approach to the spectrophotometric determination of metronidazole and tinidazole using p-dimethylaminobenzaldehyde.

Acta Pharmaceutica — Fri, 20 Nov 2009 21:28:21 +0100

Authors: Adegoke OA, Umoh OE A new approach to the spectrophotometric determination of metronidazole (MZ) and tinidazole (TZ) has been developed. The procedure involves coupling of diazotized nitroimidazoles with p-dimethylaminobenzaldehyde (DMAB) to form a greenish-yellow solution. Optimal temperature and time were 0 degrees C (iced) and 3 minutes for diazotization and 30 degrees C and 2 minutes for coupling for both MZ and TZ. Coloured adducts of MZ and TZ showed shoulders at 406 nm and 404 nm, respectively, which were selected as analytical wavelengths. The reaction with p-DMAB occurred in a 1:1 mole ratio. Beer's law was obeyed within the 4.8-76.8 mug mL-1 concentration range with low limits of detection. The azo adducts were stable for over a week. Molar absorptivities were 1.10 x...

Development of a radiolabeled beta-human chorionic gonadotropin.

Acta Pharmaceutica — Fri, 20 Nov 2009 21:28:19 +0100

Authors: Jalilian AR, Khoshdel MR, Garousi J, Yousefnia H, Hosseini MA, Rajabifar S, Sardari D beta-Human chorionic gonadotropin (beta-hCG) was successively labeled with [67Ga]-gallium chloride after conjugation with freshly prepared diethylenetriaminepentaacetic acid dianhydride (ccDTPA). After solid phase purification of the radiolabeled hormone, high performance liquid chromatography showed radiochemical purity higher than 95 % under optimized conditions (specific activity = 22-23 TBq mM-1, labeling efficiency 80 %). Preliminary in vivo studies (ID g-1, %) in male wild-type rats showed marked gonadal uptake of the tracer after 240 minutes in agreement with the biodistribution studies and reported beta-hCG receptors. Target to blood ratios were 5.1 and 15.2 after 3 and 24 hours, resp...

Synthesis, anticancer and cytostatic activity of some 6H-indolo[2,3-b]quinoxalines.

Acta Pharmaceutica — Fri, 20 Nov 2009 21:28:16 +0100

Authors: Karki SS, Hazare R, Kumar S, Bhadauria VS, Balzarini J, De Clercq E Various 6-aralkyl-9-substituted-6H-indolo[2,3-b]quinoxalines were synthesized by reaction of 1,5-disubstituted 2,3-dioxo-2,3-dihydroindole and orthophenylene diamine. Appreciable anticancer activity of compounds 5b, 5d, 5g and 5l at various cell lines among 59 human tumor cell panels was observed. All the synthesized compounds were evaluated for cytostatic activity against human Molt 4/C8 and CEM T-lymphocytes as well as for murine L1210 leukemia cells. Compound 5h exhibited an I C50 of 23 mumol L-1 against Molt 4/C8 and 38 mumol L-1 against CEM compared to melphalan 3.2 mumol L-1 and 2.5 mumol L-1, respectively. The I C50 for compound 7i against L1210 was 7.2 mumol L-1 compared to melphalan 2.1 mumol L-1. ...

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Synthesis and preliminary screening of benzothiazol-2-yl thiadiazole derivatives for anticonvulsant activity.

Acta Pharmaceutica — Fri, 20 Nov 2009 21:28:14 +0100

Authors: Siddiqui N, Rana A, Khan SA, Haque SE, Arshad MF, Ahmed S, Ahsan W Various N-(5-chloro-6-substituted-benzothiazol-2-yl)-N'-(substituted phenyl)-[1,3,4]thiadiazole-2,5-diamines (5a-t) were designed and synthesized starting from substituted acetophenones. Structures of all the compounds were confirmed on the basis of spectral and elemental analyses. All the newly synthesized compounds were screened for their anticonvulsant activity and were compared with the standard drug phenytoin sodium. Interestingly, all the compounds showed protections against seizures in the range 50-100% indicative of the promising nature of the compounds against seizure spread. Compounds 5b and 5c showed complete protection against MES induced seizures. PMID: 19919933 [PubMed - as supplied by publish...

Physicochemical characterization of solid dispersion systems of tadalafil with poloxamer 407.

Acta Pharmaceutica — Fri, 20 Nov 2009 21:28:11 +0100

Authors: Vyas V, Sancheti P, Karekar P, Shah M, Pore Y Dissolution behaviour of a poorly water-soluble drug, tadalafil, from its solid dispersion systems with poloxamer 407 has been investigated. Solid dispersion systems of tadalafil were prepared with poloxamer 407 in 1:0.5, 1:1.5 and 1:2.5 ratios using the melting method. Characterization of binary systems with FTIR and XRPD studies demonstrated the presence of strong hydrogen bonding interactions, a significant decrease in crystallinity and the possibility of existence of amorphous entities of the drug. In the binary systems tested, 1:0.5 proportion of tadalafil/poloxamer 407 showed rapid dissolution of tadalafil (DE30 70.9 +/- 3.6 %). In contrast, higher proportions of poloxamer 407 (1:1.5 and 1:2.5) offered no advantage towards di...

Chemical composition of endemic Centaurea austro-anatolica and studies of its antimicrobial activity against multi-resistant bacteria.

Acta Pharmaceutica — Fri, 20 Nov 2009 21:28:09 +0100

Authors: Ugur A, Sarac N, Ceylan O, Duru ME Hexane, chloroform, ethyl acetate and ethanolic extracts of the aerial parts of Centaurea austro-anatolica Hub.-Mor. (Asteraceae) were evaluated against microorganisms, including multiresistant bacteria, using a paper disc diffusion method. The chloroform extract exhibited significant antibacterial activity toward all bacteria tested. The chemical composition of the chloroform extract was determined by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). The major compounds of the extract were caryophyllene oxide (21.32 %), spathulenol (10.86 %), n-tricosanol (9.58 %) and geranyl isovalerate (8.71 %). PMID: 19919935 [PubMed - as supplied by publisher] (Source: Acta Pharmaceutica)

An improved procedure for synthesis of some new 1,3-diaryl-2-propen-1-ones using PEG-400 as a recyclable solvent and their antimicrobial evaluation.

Acta Pharmaceutica — Fri, 20 Nov 2009 21:28:06 +0100

Authors: Dawane BS, Konda SG, Shaikh BM, Bhosale RB A simple and convenient route is described for the synthesis of novel hetero 1,3-diaryl-2-propen-1-ones (chalcones) by using recyclable PEG-400 as an alternative reaction solvent. The reaction is clean with excellent yield, shorter reaction time and reduces the use of volatile organic compounds (VOCs). All the synthesized compounds were evaluated for their antimicrobial activities against several pathogenic representatives. PMID: 19919936 [PubMed - as supplied by publisher] (Source: Acta Pharmaceutica)

Pharmacokinetic Comparison of a Delayed-Release Combination of Doxylamine Succinate and Pyridoxine Hydrocholoride (Diclectin) and Oral Solutions of These Drugs in Healthy Women of Childbearing Age.

The Canadian Journal of Clinical Pharmacology — Fri, 20 Nov 2009 21:16:02 +0100

ConclusionThe pharmacokinetic profile of Diclectin® well explains its documented delayed efficacy.Keywords: Nausea and vomiting of pregnancy; pregnancy; pharmacokinetics; doxylamine succinate; pyridoxine chloride; pyridoxal, pyridoxamine, pyridoxal-5 phosphate PMID: 19923636 [PubMed - as supplied by publisher] (Source: The Canadian Journal of Clinical Pharmacology)

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Herbs, Vitamins and Minerals in the Treatment of Premenstrual Syndrome: A Systematic Review.

The Canadian Journal of Clinical Pharmacology — Fri, 20 Nov 2009 21:16:02 +0100

Conclusion Only calcium had good quality evidence to support its use in PMS. Further research is needed, using RCTs of adequate length, sufficient sample size, well-characterized products and measuring the effect on severity of individual PMS symptoms. PMID: 19923637 [PubMed - as supplied by publisher] (Source: The Canadian Journal of Clinical Pharmacology)

Sleep Medication Use in Canadian Seniors.

The Canadian Journal of Clinical Pharmacology — Fri, 20 Nov 2009 21:16:02 +0100

ConclusionsThis study provides important new information on the use of sleep medication by older Canadians. Overall sleep medication use and proportion of sleep medication prescribed are separate parameters with potentially different distributions, e.g., Quebec showed the same amount of sleep medication use as elsewhere, but a much higher proportion of it was prescribed.Key words: Sleep medication; comorbidity; elderly; quality of sleep PMID: 19923638 [PubMed - as supplied by publisher] (Source: The Canadian Journal of Clinical Pharmacology)

FDA Warns of Bacteria in Nasal Spray

MedPage Today Product Alert — Fri, 20 Nov 2009 15:49:33 +0100

WASHINGTON (MedPage Today) -- Several lots of Vicks Sinex nasal spray have been recalled because of bacteria found in the solution during a quality control inspection, the FDA announced. (Source: MedPage Today Product Alert)

Tories call for NHS pricing reform

Pharmacy Europe — Fri, 20 Nov 2009 14:05:50 +0100

Shadow Health Secretary Andrew Lansley has said NHS drugs should have a "value based pricing" system to prevent patients being denied medicines after a row broke out over advanced liver cancer treatment (Source: Pharmacy Europe)

Fake drugs "are top public concern"

Pharmacy Europe — Fri, 20 Nov 2009 14:05:50 +0100

Fake drugs and medicines are becoming a top concern among members of the public, who want to see stiff prison sentences introduced for counterfeiters (Source: Pharmacy Europe)

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New gastric cancer drug approved

Pharmacy Europe — Fri, 20 Nov 2009 14:05:50 +0100

A drug to treat the seventh most common cancer in Europe has been approved by the European Medicines Agency (EMEA) (Source: Pharmacy Europe)

Results from study with Xarelto to be presented at ASH 2009

Pharmacy Europe — Fri, 20 Nov 2009 14:05:50 +0100

EINSTEIN-extension trial demonstrates Xarelto's significant benefit in the secondary prevention of recurrent symptomatic VTE (Source: Pharmacy Europe)

FDA Approves Intravenous Formulation Of Pfizer's Revatio (Sildenafil) For The Treatment Of Pulmonary Arterial Hypertension

Drugs.com - New Drug Approvals — Fri, 20 Nov 2009 14:03:42 +0100

Revatio is the Only Treatment in Its Class with Both Oral and Intravenous Formulations NEW YORK--(BUSINESS WIRE)--Nov 20, 2009 - Pfizer announced today that the U.S. Food and Drug Administration (FDA) has approved Revatio (sildenafil) Injection,... (Source: Drugs.com - New Drug Approvals)

New Chemical May Play Key Role In Hospital Superbugs' Battle, UK

MRSA / Drug Resistance News From Medical News Today — Fri, 20 Nov 2009 08:00:00 +0100

A new chemical compound that mimics the body's ability to fight bacteria could help target hospital-acquired infections such as MRSA and C.difficile. The compound, which could be added to detergents or used as a coating for hospital equipment, is able to trap and release the gas nitric oxide - which is also produced by our own immune systems to kill bugs. (Source: MRSA / Drug Resistance News From Medical News Today)

FELODIPINEtablet, Film Coated, Extended Release [Mylan Pharmaceuticals Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 20 Nov 2009 05:00:00 +0100