MedWorm: ENT & OMF Top 20

Long-term efficacy of submucosal uvulopalatopharyngoplasty for obstructive sleep apnea syndrome

European Archives of Oto-Rhino-Laryngology — Mon, 09 Jan 2012 19:37:51 +0100

The objective of the study was the assessment of the long-term efficacy of submucosal uvulopalatopharyngoplasty in patients with obstructive sleep apnea syndrome. Thirty-two of 156 patients who underwent UPPP between January 2001 and March 2007 with a follow-up period of 36–96 months (mean, 56 months) were included in the study conducted at the university affiliated center. Preoperative and postoperative snoring evaluation forms and Epworth Sleepiness Scale (ESC) scores were used for subjective analysis. Preoperative and postoperative respiratory distress index (RDI) levels were evaluated objectively. Patients who had 50% or more reduction in RDI levels postoperatively were named as responders to the procedure. The other patients were named as non-responders. Body mass in...

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Palatal implants in the treatment of obstructive sleep apnea: a randomised, placebo-controlled single-centre trial

European Archives of Oto-Rhino-Laryngology — Mon, 09 Jan 2012 06:33:01 +0100

Abstract Palatal implants have been used to treat snoring and mild to moderate obstructive sleep apnea (OSA). Two previous controlled trials have published conflicting results regarding the effects of palatal implants on objective outcome measures, although they both could demonstrate superiority over placebo. The aim of the present study was to assess the effects of palatal implants in patients with mild to moderate sleep apnea in a randomised, placebo-controlled trial. Twenty-two patients with mild to moderate OSA (AHI 18 ± 5, BMI 28 ± 3, age 51 ± 13 years) due to palatal obstruction were enrolled in this randomised, double-blind, placebo-controlled trial. Respiratory parameters and sleep efficiency (evaluated by polysomnography), sno...

Sentinel node biopsy for oral and laryngopharyngeal squamous cell carcinoma: A retrospective study of 177 patients in Japan

Auris, Nasus, Larynx — Sun, 08 Jan 2012 20:04:34 +0100

Conclusion: Frozen section analysis, particularly multislice sectioning, offers a relatively reliable intraoperative diagnostic method. We were able to perform immediate neck dissection based on the results of multislice sectioning as a single-stage procedure. (Source: Auris, Nasus, Larynx)

Celiac disease and sensorineural hearing loss in children.

Acta Oto-Laryngologica — Fri, 13 Jan 2012 04:13:35 +0100

Conclusion: Sensorineural hearing loss (SNHL) is a neurological situation and celiac disease (CD) may be seen coincidentally. Children with clinical signs of hearing deficiency of unknown etiology should be assessed for CD. Objective: CD is a chronic inflammatory gluten-dependent intestinal disease and has extraintestinal findings. The aim of this study was to determine the incidence of CD and SNHL in our pediatric patients. Methods: A total of 25 pediatric patients (50 ears) with biopsy-proven CD were diagnosed in the pediatric gastroenterology department; 25 healthy control subjects (50 ears) were also included in the study. All subjects underwent pure tone audiometry at frequencies of 250-8000 Hz and tympanometry. Results: In the patients and controls, normal peak compliance, gradient, ...

Preoperative predictive model of cervical lymph node metastasis combining fluorine-18 fluorodeoxyglucose positron-emission tomography/computerized tomography findings and clinical factors in patients with oral or oropharyngeal squamous cell carcinoma

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics — Thu, 26 Jan 2012 20:43:21 +0100

Conclusions: The use of predictive models that include clinical factors and delayed-phase SUVmax and SUV-IR improve preoperative nodal diagnosis. (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)

Evaluation of symptoms and QOL with calcium alginate versus chitin-coated gauze for middle meatus packing after endoscopic sinus surgery

Auris, Nasus, Larynx — Sun, 08 Jan 2012 20:04:34 +0100

Conclusion: Sorbsan® packing did not cause any major complications and has the potential to reduce nasal pain and suffering in post ESS patients compared with gauze packing. (Source: Auris, Nasus, Larynx)

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Sleep medicine

The Laryngoscope — Mon, 23 Jan 2012 20:19:59 +0100

(Source: The Laryngoscope)

The value of PET/CT to assess clinically negative necks

European Archives of Oto-Rhino-Laryngology — Tue, 17 Jan 2012 07:18:53 +0100

Abstract The aim was to evaluate the efficacy of [18F]-2-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) in evaluating metastasis of head and neck squamous cell carcinoma (HNSCC) to the cervical lymph nodes, with specific attention to the efficacy in regard to clinically negative necks. This was a retrospective review of 243 patients with HNSCC between years 2005 and 2007 treated at a comprehensive cancer care institution who underwent pre-operative PET/CT and neck dissection with either an N0 (112 patients) or N+ (131 patients) clinical nodal status. PET/CT findings were correlated with histopathological results of surgical specimens. A majority of the primary sites were oral cavity and oropharynx (70%), followed by larynx, unknown primary and ...

Prevalence and causes of dysphonia in a large treatment‐seeking population

The Laryngoscope — Mon, 23 Jan 2012 20:20:24 +0100

Conclusions:This analysis of insurance claims data from a nationally representative database represents the largest study of its kind. Important differences in dysphonia prevalence related to age, sex, diagnosis, and physician type were identified. Laryngoscope, 122:343–348, 2012 (Source: The Laryngoscope)

Gingival bleeding and jaw bone necrosis in patients with metastatic renal cell carcinoma receiving sunitinib: Report of 2 cases with clinical implications

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics — Thu, 26 Jan 2012 20:43:21 +0100

We report on 2 patients with mRCC treated with sunitinib. The first patient, a 19-year-old woman, treated with cisplatin and sunitinib, presented with oral pain, malodor, spontaneous and continuous gingival bleeding, and painful necrotic ulcerations clinically resembling necrotizing ulcerative gingivitis (NUG). Suntinib-related stomatitis and bleeding were considered cumulative to NUG symptoms. The second patient, a 64-year-old woman, treated with sunitinib only, complained of mandibular pain. Sunitinib-related jaw osteonecrosis was diagnosed. Gingival bleeding and soft tissue necrosis, as well as jaw osteonecrosis may develop as adverse events of sunitinib use. Antiangiogenic therapies are increasingly used in the treatment of cancers. The presented cases are aimed to alert health care pr...

Expression of myelin basic protein in the human auditory nerve—An immunohistochemical and comparative study

Auris, Nasus, Larynx — Sun, 08 Jan 2012 20:04:33 +0100

Conclusions: The pattern of myelination in human spiral ganglion is different from that in other species’ spiral ganglion. The striking differences in myelin outline should be investigated further in combination with its influence on signal coding and preservation properties in man. (Source: Auris, Nasus, Larynx)

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Are temporomandibular disorder symptoms and diagnoses associated with pubertal development in adolescents? An epidemiological study

Journal of Orofacial Orthopedics/Fortschritte der Kieferorthopadie — Tue, 10 Jan 2012 16:58:46 +0100

Conclusion Pubertal development increases the probability of self-reported TMD symptoms among girls, while the probability thereof decreases among boys. Independent of sex, pubertal growth increases the prevalence of RDC/TMD-related diagnoses—mainly disk displacement—in both sexes. Content Type Journal ArticleCategory Original articlePages 1-12DOI 10.1007/s00056-011-0056-xAuthors C. Hirsch, Department of Pediatric Dentistry, Dental School, University of Leipzig, Nürnberger Str. 57, 04103 Leipzig, GermanyJ. Hoffmann, Private Practice, Erlau/Crossen, GermanyJ.C. Türp, Dental School, University of Basel, Basel, Switzerland Journal Journal of Orofacial Orthopedics/Fortschritte der Kieferorthopädie Online ISSN 1615-6714Print ISSN 1434-5293 (Source: Journal ...

Upper airway symptoms in primary snoring and in sleep apnea.

Acta Oto-Laryngologica — Wed, 04 Jan 2012 05:00:00 +0100

Conclusions: Upper airway symptoms were common in subjects referred for sleep study. In particular, nasal stuffiness and airway dryness already seemed to bother snorers before development of obstructive sleep apnea syndrome (OSAS). Mouth dryness increased with severity of obstructive sleep apnea (OSA). Objectives: Upper airway symptoms are common in patients with OSAS. However, prevalence of these symptoms is unknown in primary snoring and mild OSA. We evaluated frequency of upper airway symptoms in a large group of patients referred for diagnostic sleep studies. Methods: We examined 524 consecutive subjects (69% men, mean ± SD age 51 ± 12 years, apnea-hypopnea index (AHI) 15 ± 21, body mass index 31 ± 6) by a questionnaire-based survey. The subjects filled in a questionnaire enquiring...

Alterations of Smad expression and activation in defining 2 subtypes of human head and neck squamous cell carcinoma

Head and Neck — Thu, 26 Jan 2012 20:33:28 +0100

ConclusionOur results indicate that HNSCC in which Smad2/3 are inactivated or in which Smad4 expression is lost represent 2 distinct tumor subtypes with different clinical outcomes. © 2012 Wiley Periodicals, Inc. Head Neck, 2012 (Source: Head and Neck)

Clinical significance of elevated spleen tyrosine kinase expression in nasopharyngeal carcinoma

Head and Neck — Sun, 29 Jan 2012 20:16:00 +0100

ConclusionHigh expression of Syk, which results partly from LMP2A expression in NPC, is associated with tumor recurrence and poor prognosis of patients with NPC. © 2012 Wiley Periodicals, Inc. Head Neck, 2012 (Source: Head and Neck)

Variations of the Cervical Internal Carotid Artery

Indian Journal of Otolaryngology and Head and Neck Surgery — Thu, 05 Jan 2012 17:01:22 +0100

The objective of this study was to report the variations of the cervical internal carotid artery, as encountered during neck dissection for head and neck malignancies. A retrospective analysis of neck dissections performed for the management of various head and neck cancers, during 2006–2010 was carried out. Among 102 patients and 119 neck dissections, five of them were found to be having abnormalities of the cervical part of the internal carotid artery during its course in the neck and were analyzed in detail. Out of five subjects, four were males and the other was female with age ranging from 50 to 74 years. Of the five patients two had mild degree of tortuosity, two patients had moderate degree of tortuosity and another patient had severe degree of tortuosity in the course ...

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Cobalt-based dental alloy, allergy to cobalt, and palmoplantar pustulosis

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics — Thu, 26 Jan 2012 20:43:20 +0100

Song et al., in their case report, documented the first observations of idiopathic palmoplantar pustulosis (PPP) due to cobalt allergy released from dental crowns. Because we have long been interested in skin diseases associated with dental alloy restorations, we would like to emphasize 2 points about this case study. It would have been interesting if the authors had included mercury compound allergens for screening for contact allergy to dental amalgam, because mercury has been associated with PPP. There is evidence that PPP is a chronic inflammatory disease of the skin, in which inflammation is driven by leukocyte infiltration with associated pustular lesions caused and/or exacerbated by metals. In this regard, it is well known that mercury-containing dental amalgam filling releases elem...

Is severe dysplasia the same lesion as carcinoma in situ? 10-Year follow-up of laryngeal precancerous lesions.

Acta Oto-Laryngologica — Mon, 09 Jan 2012 05:00:00 +0100

Conclusion. Our results showed that the behavior of moderate dysplasia lesions was more like that of severe dysplasia lesions, while severe dysplasia was very different from carcinoma in situ (CIS). CIS should be managed more aggressively than the other lesions. Mild dysplasia could not be viewed as a precancerous lesion of the larynx. Objective: This study aimed to identify the possibilities of the precancerous lesions of larynx (including mild dysplasia, moderate dysplasia, severe dysplasia, and CIS) progressing to invasive carcinomas and to highlight the importance of adequate management and follow-up strategies for these patients. Methods: A retrospective study of patients who had these preinvasive lesions in the larynx over a 10-year period was performed. Results: These patients were ...

Pattern and predictive factors of regional lymph node metastasis in papillary thyroid carcinoma: A prospective study

Head and Neck — Mon, 23 Jan 2012 20:12:15 +0100

ConclusionsIpsilateral central neck dissection is recommended for all PTC patients. Careful inspection for LN metastasis should be performed when evaluating male patients with PTC, and if central LNs are involved, carefully inspect lateral LNs. © 2012 Wiley Periodicals, Inc. Head Neck, 2012 (Source: Head and Neck)

Epithelial Myoepithelial Carcinoma of Head and Neck Region

Indian Journal of Otolaryngology and Head and Neck Surgery — Fri, 20 Jan 2012 07:07:43 +0100

The objective of the study is to document the clinical, histopathological and immunological findings of epithelial myoepithelial carcinoma (EMEC) which is an uncommon neoplasm. The tumour represents less than 0.5–1% of all salivary gland neoplasms. As per literature, it involves the parotid gland most frequently and rarely, the minor salivary glands. We are reporting a series of four cases of EMEC over a period of one and half years, three from minor salivary glands at different sites and one from the deep lobe of parotid. Interestingly, the pre operative FNAC of all the cases revealed benign pathology. Recurrence occurred in three of them after tumour excision. One patient was subjected to post operative radiotherapy and one patient to chemotherapy. Histopathology and immunohistoc...