MedWorm: Endocrinology Top 20

Swine flu information sheet for patients taking hydrocortisone

Society for Endocrinology — Fri, 19 Feb 2010 12:00:00 +0100

Download Swine flu information sheet for patients taking hydrocortisone (pdf) (135kb) (Source: Society for Endocrinology)

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TaiGen Announces Nemonoxacin (TG-873870) Once-A-Day Oral Dosing In Diabetic Foot Infection Met Primary Endpoints

Diabetes News From Medical News Today — Sat, 13 Mar 2010 09:00:00 +0100

TaiGen Biotechnology Co., Ltd. announced the Phase II trial of nemonoxacin (TG-873870) in Diabetic Foot Infection (DFI) with once-a-day dosing met the primary endpoints and showed promising clinical efficacy and good tolerability. Nemonoxacin is a novel non-fluorinated quinolone that has a broad spectrum of activity against gram-positive and gram-negative bacteria and atypical pathogens... (Source: Diabetes News From Medical News Today)

Usefulness of Vegetarian and Vegan Diets for Treating Type 2 Diabetes

Current Diabetes Reports — Wed, 10 Mar 2010 16:21:31 +0100

This article reviews observational studies and intervention trials on such diets, and discusses their efficacy, nutritional adequacy, acceptability, and sustainability. Research to date has demonstrated that a low-fat, plant-based nutritional approach improves control of weight, glycemia, and cardiovascular risk. These studies have also shown that carefully planned vegan diets can be more nutritious than diets based on more conventional diet guidelines, with an acceptability that is comparable with that of other therapeutic regimens. Current intervention guidelines from professional organizations offer support for this approach. Vegetarian and vegan diets present potential advantages in managing type 2 diabetes that merit the attention of individuals with diabetes and their caregiver...

Associations of Estrogen Receptor Alpha and Beta Gene Polymorphisms with Sex Steroid Levels and Body Fat Content in Men

Experimental and Clinical Endocrinology and Diabetes — Thu, 04 Mar 2010 14:23:38 +0100

Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1249006Abstract Estrogens play an important role in male physiology. We investigated the possible association of four single nucleotide polymorphisms in Estrogen Receptor α () and Estrogen Receptor β () genes with circulating levels of sex steroids and Sex Hormone Binding Globulin (SHBG) in men.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Abstract | Full text (Source: Experimental and Clinical Endocrinology and Diabetes)

Growth Impairment in a Boy with Late-Onset Congenital Adrenal Hyperplasia and Anorexia Nervosa1

Experimental and Clinical Endocrinology and Diabetes — Wed, 03 Mar 2010 14:22:41 +0100

Exp Clin Endocrinol DiabetesDOI: 10.1055/s-0030-1248309AbstractTreatment of congenital adrenal hyperplasia (CAH) in its salt-wasting form with appropriate doses of glucocorticoids and mineralocorticoids should promote growth, puberty and final height in a similar to normal pattern. However, the individual requirements for these drugs to normalize the hormonal profile and to achieve a physiologic growth pattern may differ. Moreover, the time of onset of puberty is also unpredictable since the course of the disease may predispose for precocity. The aim of this study was to explain the unexpected arrest of growth during puberty in a boy with late-onset CAH, who had been treated with glucocorticoid from early childhood. A short course of GnRH agonist treatment was also introduced in later year...

Lasofoxifene Helps Reduce Risk Of Bone Fractures, Breast Cancer, Heart Disease And Stroke

Endocrinology News From Medical News Today — Thu, 25 Feb 2010 11:00:00 +0100

Low doses of the medication lasofoxifene can reduce the risk of vertebral and non-vertebral fractures, ER-positive breast cancer, coronary heart disease and stroke in postmenopausal women with osteoporosis. That's the finding of a new study in the latest issue of the New England Journal of Medicine... (Source: Endocrinology News From Medical News Today)

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Effective Prostate Cancer Treatment Discovery

Endocrinology News From Medical News Today — Sat, 27 Feb 2010 08:00:00 +0100

Monash University biomedical scientists have identified a new way to treat castrate resistant cells in prostate cancer sufferers - the most common cancer in Australian men. For more than 60 years the main way to treat men with prostate cancer has involved removing the hormones that fuel growth of the cancer cells... (Source: Endocrinology News From Medical News Today)

TE Possible Alternative to Liver Biopsy

Clinical Endocrinology News — Fri, 01 Jan 2010 00:00:00 +0100

NEW YORK — Transient elastography correlated with aminotransferase levels in a cross-sectional study of 22 adolescent and young women with Turner's syndrome. Transient elastography (TE), a novel technique for measuring liver stiffness, has been widely validated as a noninvasive alternative to liver biopsy for evaluating hepatic fibrosis in patients with chronic hepatitis C. It has not been used in Turner's syndrome (TS) patients, in whom liver involvement is common. (Source: Clinical Endocrinology News)

America's Biopharmaceutical Companies Studying 183 New Medicines To Counter Diabetes Growth

Diabetes News From Medical News Today — Sat, 20 Feb 2010 09:00:00 +0100

A Stratton Spotlight article recently highlighted a Centers for Disease Control and Prevention (CDC) survey that showed a dramatic rise in the number of diabetes cases during the last 10 years and noted that pharmaceutical research and biotechnology companies are working on nearly 200 new medicines to treat this debilitating disease... (Source: Diabetes News From Medical News Today)

Insulin glargine and insulin have identical effects on proliferation and phosphatidylinositol 3-kinase/AKT signalling in rat thyrocytes and human follicular thyroid cancer cells

Diabetologia — Wed, 24 Feb 2010 06:51:38 +0100

Content Type Journal ArticleCategory LetterDOI 10.1007/s00125-010-1674-3Authors K. Müller, University of Leipzig Department of Internal Medicine, Division of Endocrinology and Nephrology Liebigstr. 18 04103 Leipzig GermanyC. Weidinger, University of Leipzig Department of Internal Medicine, Division of Endocrinology and Nephrology Liebigstr. 18 04103 Leipzig GermanyD. Führer, University of Leipzig Department of Internal Medicine, Division of Endocrinology and Nephrology Liebigstr. 18 04103 Leipzig Germany Journal DiabetologiaOnline ISSN 1432-0428Print ISSN 0012-186X (Source: Diabetologia)

Hepatitis C And Insulin Resistance - Surprising Findings

Diabetes News From Medical News Today — Wed, 10 Mar 2010 11:00:00 +0100

We have known for several years that Hepatitis C, a common cause of liver cirrhosis and cancer, also makes people three to four times more likely to develop Type 2 diabetes. In studying the insulin resistance of 29 people with Hepatitis C, Australian researchers have confirmed that they have high insulin resistance, a precursor to diabetes... (Source: Diabetes News From Medical News Today)

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New Building At University Of Michigan Health System Expands Eye Care, Unites Diabetes Researchers

Diabetes News From Medical News Today — Sun, 28 Feb 2010 09:00:00 +0100

On March 1, the first eye patients will enter an innovative new $132 million facility that expands the University of Michigan Health System's capacity for eye care, research and education, and unites diabetes researchers as they work to accelerate the search for a cure and prevention of diabetes. The Brehm Tower at the W.K... (Source: Diabetes News From Medical News Today)

The Times Cheltenham Science Festival 2010 needs volunteers

Society for Endocrinology — Thu, 04 Mar 2010 12:00:00 +0100

The Times Cheltenham Science Festival is a five-day extravaganza of science, engineering, technology and arts, with events for adults, schools and for the whole family. Aimed purely at the general public, the festival covers a range of topics from tissue engineering and aerodynamics to the science of chocolate and sleep. Running from 7 - 14 June, the Cheltenham Science Festival is looking for volunteers to help run it's multitude of workshops, talks and events. This is a great way of getting involved in public engagement with science, and gives you the opportunity to work with some of the country's leading scientists. Food, and accomodation will be provided, and travel expenses will be covered. Interested parties should send CV and a covering letter explaining why you'd like to volunteer...

Link Between Hepatitis C And Insulin Resistance Surprises Scientists

Diabetes News From Medical News Today — Tue, 09 Mar 2010 20:00:00 +0100

Scientists in Australia found that when they studied insulin resistance in people with Hepatitis C little or none of it was in the liver and nearly all the insulin resistance occured in muscle, which surprised them because Hepatitis C is a liver disease that not only leads to cirrhosis and cancer, but also makes people three to four times more likely to develop Type 2 diabetes... (Source: Diabetes News From Medical News Today)

Effects of Restless Legs Syndrome on Quality of Life and Psychological Status in Patients With Type 2 Diabetes

The Diabetes Educator — Thu, 25 Feb 2010 21:07:56 +0100

Conclusions Among individuals with diabetes, RLS can impair mental health, increasing the risk for anxiety and depression. Since RLS consequences on nocturnal rest and psychological status may impair glycemic control in this population, diabetologists and diabetes educators should investigate for the presence of RLS in their patients and treat them. (Source: The Diabetes Educator)

Regulation of the Angiopoietin-2 Gene by hCG in Ovarian Cancer Cell Line OVCAR-3

Hormone and Metabolic Research — Tue, 09 Mar 2010 14:27:38 +0100

In conclusion, we have demonstrated that the regulation of ANG2-expression in ovarian cancer cells is hCG-dependent and we suggest that forkhead transcription factor and C/EBP-dependent pathways are involved in the regulation of ANG2-expression in ovarian cancer cells.[...]© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Abstract | Full text (Source: Hormone and Metabolic Research)

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Generic Drug For Type 2 Diabetes Passes Next Clinical Hurdle

Diabetes News From Medical News Today — Tue, 16 Mar 2010 08:00:00 +0100

Clinical studies of a generic drug called salsalate, widely prescribed for arthritis, now provide early promising results that it may be useful for the treatment of patients with type 2 diabetes as well. Salsalate is an atypical non-steroidal anti-inflammatory agent that is chemically similar to aspirin but a bit easier on the stomach... (Source: Diabetes News From Medical News Today)

Bone pills 'may cut breast cancer risk' (the Daily Express, 3 March 2010)

Society for Endocrinology — Wed, 03 Mar 2010 12:00:00 +0100

A US case control study has found that the risk of breast cancer is significantly reduced in women taking bisphosphonates for osteoporosis. Full article (Source: Society for Endocrinology)

Doxorubicin-induced ovarian toxicity

Reproductive Biology and Endocrinology — Thu, 04 Mar 2010 00:00:00 +0100

Conclusions: Our results may imply a mechanism of chemotherapy-induced ovarian toxicity, manifested by reduced ovulation and accompanied by a reduction in ovarian size, caused probably by an acute insult to the ovary. (Source: Reproductive Biology and Endocrinology)

Liraglutide approved by FDA for treatment Type 2 diabetes

MedWire News - Diabetes — Sat, 20 Feb 2010 14:17:54 +0100

The US Food and Drug Administration has approved the glucagon-like peptide-1 receptor agonist liraglutide for treatment of Type 2 diabetes, with some stipulations, including requests for further studies to assess possible safety risks. (Source: MedWire News - Diabetes)