MedWorm: Endocrinology

A Systematic Review of Physical Activity Interventions in Hispanic Adults

Experimental Diabetes Research — Wed, 08 Feb 2012 19:49:39 +0100

Healthy People 2020 aims to achieve health equity, eliminate disparities, and improve the health of all groups. Regular physical activity (PA) improves overall health and fitness and has the capability to reduce risk for chronic diseases. Identifying barriers which relate to the Hispanic population is important when designing PA interventions. Therefore, the purpose was to review existing PA interventions targeting Hispanic adults published between 1988 and 2011. This paper was limited to interventions which included more than 35% Hispanic adults (n=20). Most of the interventions were community based (n=16), although clinical, family-based, and faith-based settings were also represented. Interventions incorporated theory (n=16), with social cognitive theory and transtheoretical model being...

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On Functions of Bounded (p,k)-Variation

Experimental Diabetes Research — Wed, 08 Feb 2012 19:49:39 +0100

We introduce and study the concept of (p,k)-variation (1<p<∞, k∈N) of a real function on a compact interval. In particular, we prove that a function u:[a,b]→R has bounded (p,k)-variation if and only if u(k-1) is absolutely continuous on [a,b] and u(k) belongs to Lp[a,b]. Moreover, an explicit connection between the (p,k)-variation of u and the Lp-norm of u(k) is given which is parallel to the classical Riesz formula characterizing functions in the spaces RVp[a,b] and Ap[a,b]. This may also be considered as an alternative characterization of the one variable Sobolev space Wpk[a,b]. (Source: Experimental Diabetes Research)

Low-Level Detection of Poly(amidoamine) PAMAM Dendrimers Using Immunoimaging Scanning Probe Microscopy

Experimental Diabetes Research — Wed, 08 Feb 2012 19:49:39 +0100

Immunoimaging scanning probe microscopy was utilized for the low-level detection and quantification of biotinylated G4 poly(amidoamine) PAMAM dendrimers. Results were compared to those of high-performance liquid chromatography (HPLC) and found to provide a vastly improved analytical method for the low-level detection of dendrimers, improving the limit of detection by a factor of 1000 (LOD=2.5×10−13 moles). The biorecognition method is reproducible and shows high specificity and good accuracy. In addition, the capture assay platform shows a promising approach to patterning dendrimers for nanotechnology applications. (Source: Experimental Diabetes Research)

Travel Time Model of Left-Turning Vehicles at Signalized Intersection

Experimental Diabetes Research — Wed, 08 Feb 2012 19:49:39 +0100

The travel time of left-turning vehicles at signalized intersection was discussed. Under the assumption that the opposing through vehicles headway follows M3 distribution, the travel time model was established on the basis of gap theory and queue theory. Comparison was done with the common model based on the assumption that the opposing through vehicles headway follows negative exponential distribution. The results show that the model in this paper has stronger applicability and its most relative error is less than 15%. In addition, the sensitivity analysis was done. The results show that the opposing through flow rate has significant impact on travel time. The impact of left-turning flow rate and following headway is light when the opposing through flow rate is small, the threshold is...

Analysis of Delayed Bleeding after Endoscopic Submucosal Dissection for Gastric Epithelial Neoplasms

Experimental Diabetes Research — Wed, 08 Feb 2012 19:49:39 +0100

Conclusion. Ulcer presence/absence was considered the most significant predictor of post-ESD bleeding. (Source: Experimental Diabetes Research)

Dapagliflozin reduces weight through glucose excretion, not fluid loss

MedWire News - Diabetes — Wed, 08 Feb 2012 19:49:28 +0100

Adding dapagliflozin to metformin results in significant weight loss among diabetes patients principally as a result of caloric loss through glucose excretion rather than fluid loss, report researchers. (Source: MedWire News - Diabetes)

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Breathalyzer Device Identifies Glucose Metabolism Problems Accurately

Health News from Medical News Today — Wed, 08 Feb 2012 18:00:00 +0100

According to a study published in the peer-reviewed journal Metabolism, a "breathalyzer"-like technology, currently under development at the University of Wisconsin-Madison, may help diagnose diseases in the future. The study shows a simple, but sensitive technique, that can identify normal and disease-state glucose metabolism by a fast analysis of exhaled air or blood. Several diseases, including infections, diabetes, and cancer, change the body's metabolism in different ways... (Source: Health News from Medical News Today)

Why Coffee Drinking Reduces the Risk of Type 2 Diabetes

Diabetes News from dLife.com — Wed, 08 Feb 2012 15:46:35 +0100

January 11, 2012 (American Chemical Society) — “Coffee Components Inhibit Amyloid Formation of Human Islet Amyloid Polypeptide in Vitro: Possible Link between Coffee Consumption and Diabetes Mellitus” Journal of Agricultural & Food Chemistry read more (Source: Diabetes News from dLife.com)

Behavioral EconomicsBehavioral Economics

Medscape Today Headlines — Wed, 08 Feb 2012 15:35:24 +0100

Medscape talked to Richard Roberts, MD, AAFP Foundation president, about a demonstration program in diabetes using behavioral economics, which combines 2 standard disciplines to improve healthcare. Medscape Family Medicine (Source: Medscape Today Headlines)

Isolation of Human Islets for Autologous Islet Transplantation in Children and Adolescents with Chronic Pancreatitis

Anesthesiology Research and Practice — Wed, 08 Feb 2012 12:16:29 +0100

We present here a technical approach for the isolation and preservation of the islets proven to be efficient to obtain high numbers of islets, favoring the successful treatment of young patients. (Source: Anesthesiology Research and Practice)

Whales 'stressed by ocean noise' (BBC News Online, 8 February 2012)

Society for Endocrinology — Wed, 08 Feb 2012 12:00:00 +0100

Researchers have measured the levels of stress hormone metabolites in the faeces of whales and linked this to another study of levels of shipping noise, publishing in Proceedings of the Royal Society B. Full article (Source: Society for Endocrinology)

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Vildagliptin (Galvus?) approved for use as monotherapy in the EU (NeLM News Service, 7 February 2012)

Society for Endocrinology — Wed, 08 Feb 2012 12:00:00 +0100

Reports suggest that the European Commission has approved the use of vildagliptin (Galvus) as a monotherapy where patients with type 2 diabetes are unable to control their blood sugar with diet and exercise alone and cannot take metformin due to intolerance or contraindications. Full article (Source: Society for Endocrinology)

Edinburgh International Science Festival: The other side of sex

Society for Endocrinology — Wed, 08 Feb 2012 12:00:00 +0100

The Society returns to Edinburgh International Science Festival this year with a public event exploring sex hormones. We’ve all heard the saying, ?men are from Mars and women are from Venus’, but are we truly worlds apart? And, perhaps more intriguingly, what part might testosterone have played in the global financial crisis? Join our panel of experts for 'The other side of sex' to take place at 17:30, Wednesday 4 April at The Scottish Storytelling Centre. Click on the links below for further information on the event and for a link to the Booking Office. We look forward to seeing you all in Edinburgh. Event profile Book tickets (Source: Society for Endocrinology)

RSUMEs in pituitary adenomas

Society for Endocrinology — Wed, 08 Feb 2012 12:00:00 +0100

Pituitary tumourigenesis remains poorly understood as a process, although several promising candidate genes have been identified. The lack of genuine marker genes within pituitary tumours has led investigators to focus on alternative angles to improve the understanding of potential mechanisms of pathogenesis. In the current issue of Endocrine-Related Cancer, Shan et al. (2012) report that the novel RWD domain containing protein, RWD-containing sumoylation enhancer, is expressed in human pituitary adenomas and plays a pivotal role in regulating the hypoxia-inducible factor 1?–vascular endothelial growth factor response to hypoxia (full article at DOI: 10.1530/ERC-11-0211). Fowkes and Vlotides have a written a commentary on this work and state that these findings expand our understan...

RSUME regulates VEGF-A in pituitary tumours

Society for Endocrinology — Wed, 08 Feb 2012 12:00:00 +0100

In this study, they demonstrate RSUME expression in pituitary adenomas and its involvement in the regulation of HIF-1? and VEGF-A production in these tumours, suggesting an important role of RSUME in the process of pituitary adenoma neovascularisation. Their study suggests that the novel RWD-domain containing protein RSUME is a new and important player in pituitary tumour pathogenesis. It is overexpressed in human pituitary adenomas and critically regulates HIF-1? expression and VEGF-A production under hypoxia. Through supporting pituitary tumour neovascularisation, RSUME might be critically involved in pituitary adenoma progression. Therefore, it represents a new putative therapeutic target for the development of novel anti-angiogenic treatment concepts of human pituitary tumours. Shan et...

Methyleseleninic acid downregulates aromatase

Society for Endocrinology — Wed, 08 Feb 2012 12:00:00 +0100

Cytochrome P 450 aromatase (CYP19) is the key enzyme required for oestrogen biosynthesis and is responsible for converting androgens to oestrogens. Oestrogen is known to play a critical role in breast cancer development and progression, making aromatase an important target for breast cancer prevention and therapy. Although aromatase inhibitors have been used as first line of therapy for oestrogen receptor-positive breast cancer in post menopausal women, their use has been limited by toxicities and high costs. Gao et al. show that methylseleninic acid (MSA), can effectively suppress aromatase activation by dexamethasone and forskolin. MSA suppression of aromatase activation is not mediated through direct inhibition of aromatase enzymatic activity but is attributable to a marked downregulati...

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Effect of urocortin on osteoclasts

Society for Endocrinology — Wed, 08 Feb 2012 12:00:00 +0100

Urocortin (UCN) is a member of the corticotrophin-releasing factor (CRF) family of peptides. CRF is a classic mediator of hypothalamic stress response with UCN playing a more anxiolytic role in this response. However, there is little information on the role of UCN in the physiology or pathology of bone. Combs et al. investigated the effects of UCN on the formation and function of osteoclasts. Their study demonstrated for the first time that UCN produces marked inhibition of osteoclast differentiation and function, indicating that it is a novel regulator of resorption and acts through a direct effect on osteoclasts and their precursor cells. The study also suggests that bone could contain a local UCN system that might modulate local and/or systemic bone resorption in response to as-yet unkn...

Factors associated with a shorter time until the next pulmonary exacerbation in adult patients with cystic fibrosis.

Chronic Respiratory Disease — Wed, 08 Feb 2012 09:06:02 +0100

Authors: Sequeiros IM, Jarad N Abstract Time until the subsequent exacerbation (PEx) in cystic fibrosis (CF) is a significant health outcome and one of the significant end points in clinical trials. Risk factors associated with shorter time until the next exacerbation (TUNE) have not been reported. This is a prospective study. TUNE was the number of days from the end of intravenous (IV) antibiotic treatment of a PEx until the day of start of IV antibiotics for the following PEx. Factors assessed were age, gender, site of treatment, CF-related diabetes (CFRD), allergic bronchopulmonary aspergillosis (ABPA) and infection with Pseudomonas aeruginosa (PA). In addition, we examined parameters obtained at day 14 of treatment including forced expiratory volume in the first second (FEV1), ...

What We Eat Can Alter The Brain Regions That Regulate Body Weight

Health News from Medical News Today — Wed, 08 Feb 2012 09:00:00 +0100

An editorial authored by University of Cincinnati (UC) diabetes researchers published in the Feb. 7, 2012, issue of the journal Cell Metabolism sheds light on the biological factors contributing to rising rates of obesity and discusses strategies to reduce body weight. According to the U.S. Centers for Disease Control, about one-third of U.S. adults are obese, a number that continues to climb. "While we don't usually think of it this way, body weight is regulated... (Source: Health News from Medical News Today)

Early Signs Of Disease Detected By Metabolic 'Breathalyzer'

Health News from Medical News Today — Wed, 08 Feb 2012 09:00:00 +0100

The future of disease diagnosis may lie in a "breathalyzer"-like technology currently under development at the University of Wisconsin-Madison. New research published online in February in the peer-reviewed journal Metabolism demonstrates a simple but sensitive method that can distinguish normal and disease-state glucose metabolism by a quick assay of blood or exhaled air. Many diseases, including diabetes, cancer, and infections, alter the body's metabolism in distinctive ways... (Source: Health News from Medical News Today)

Zinc Control Mechanisms Could Be Key To Aggressive Breast Cancer Treatments

Health News from Medical News Today — Wed, 08 Feb 2012 08:00:00 +0100

The body's control mechanisms for delivering zinc to cells could be key to improving treatment for some types of aggressive breast cancer. New research by Cardiff University and King's College London has identified the switch which releases zinc into cells, with important implications for a number of diseases. Zinc has long been known to play a vital part in human health. Too much zinc, or too little, can cause cell death. A growing body of evidence links zinc to disease states including neurodegeneration, inflammation, diabetes and cancer... (Source: Health News from Medical News Today)

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Pancreas May ‘Taste’ Fructose, Hinting at Links to Diabetes

The Doctors Lounge - Endocrinology and Diabetes — Wed, 08 Feb 2012 05:00:00 +0100

High-fructose corn syrup is ubiquitous in Western diet, and study suggests it could play unique role (Source: The Doctors Lounge - Endocrinology and Diabetes)

Moffitt, Sanford-Burnham and Florida Hospital create Personalized Medicine Partnership of Florida

EurekAlert! - Medicine and Health — Wed, 08 Feb 2012 05:00:00 +0100

(Sanford-Burnham Medical Research Institute) Moffitt Cancer Center, Sanford-Burnham Medical Research Institute and Florida Hospital have announced they will collaborate on the creation of a Personalized Medicine Partnership of Florida. The partnership will conduct collaborative research to accelerate discovery and develop new treatments in the areas of cancer and metabolic diseases, including obesity, diabetes and cardiovascular disease. (Source: EurekAlert! - Medicine and Health)

Breastfeeding can reduce risk of childhood obesity

EurekAlert! - Medicine and Health — Wed, 08 Feb 2012 05:00:00 +0100

(University of Colorado Denver) Children of diabetic pregnancies have a greater risk of childhood obesity but new research from the Colorado School of Public Health shows breastfeeding can reduce this threat. (Source: EurekAlert! - Medicine and Health)

Metastases to the Thyroid: A Review of the Literature from the Last Decade

Thyroid — Wed, 08 Feb 2012 04:03:38 +0100

Thyroid , Vol. 0, No. 0. (Source: Thyroid)

Gestational Diabetes, Obesity, and Metabolic Syndrome Diagnosed During Pregnancy

Metabolic Syndrome and Related Disorders — Wed, 08 Feb 2012 04:03:01 +0100

Metabolic Syndrome and Related Disorders , Vol. 0, No. 0. (Source: Metabolic Syndrome and Related Disorders)

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Hypoglycemia, but not Glucose Variability, Relates to Vascular Function in Children with Type 1 Diabetes

Diabetes Technology — Wed, 08 Feb 2012 04:01:41 +0100

Diabetes Technology & Therapeutics , Vol. 0, No. 0. (Source: Diabetes Technology)

Pregnancy in AcromegalyPregnancy in Acromegaly

Medscape Today Headlines — Wed, 08 Feb 2012 04:00:00 +0100

Pregnancy in women with this pituitary condition is uncommon. What are the outcomes? Clinical Endocrinology (Source: Medscape Today Headlines)

MC4R Dimerization in the Paraventricular Nucleus and GHSR/MC3R Heterodimerization in the Arcuate Nucleus: Is There Relevance for Body Weight Regulation

Neuroendocrinology — Tue, 07 Feb 2012 23:00:00 +0100

Neuroendocrinology (DOI:10.1159/000334903) (Source: Neuroendocrinology)

Obesity Epidemic Linked To Brain Mechanisms

Health News from Medical News Today — Tue, 07 Feb 2012 21:00:00 +0100

America's rising rates of obesity in virtually all age groups is partly due to biological factors, researchers from the Cincinnati Diabetes and Obesity Center reported in the journal Cell Metabolism. Approximately one third of all American adults are obese today, and the percentage continues to rise, says the CDC (Centers for Disease Control and Prevention). Co-author, Randy Seeley, PhD, said: "While we don't usually think of it this way, body weight is regulated... (Source: Health News from Medical News Today)

Baby's First Foods Should Be Finger Foods (CME/CE)

MedPage Today Endocrinology — Tue, 07 Feb 2012 20:14:55 +0100

(MedPage Today) -- Children who begin eating solid finger foods rather than being given pureed baby foods by their parents developed healthier eating patterns, researchers found. (Source: MedPage Today Endocrinology)

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Quitting Smoking May Halve Risk of Oral Health Problems

The Doctors Lounge - Cardiology — Tue, 07 Feb 2012 18:00:00 +0100

Smokers four times more likely to develop oral conditions, such as mouth cancers, gum disease, study finds (Source: The Doctors Lounge - Cardiology)

American Thyroid Association Design and Feasibility of a Prospective Randomized Controlled Trial of Prophylactic Central Lymph Node Dissection for Papillary Thyroid Carcinoma

Thyroid — Tue, 07 Feb 2012 17:52:54 +0100

Thyroid , Vol. 0, No. 0. (Source: Thyroid)

Hyperuricemia and Microalbuminuria Are Separately and Independently Associated with Prehypertension Among Chinese Han Women

Metabolic Syndrome and Related Disorders — Tue, 07 Feb 2012 17:10:39 +0100

Metabolic Syndrome and Related Disorders , Vol. 0, No. 0. (Source: Metabolic Syndrome and Related Disorders)

Propylthiouracil-Induced Interstitial Pneumonia in a Caucasian Woman with Amiodarone-Induced Thyrotoxicosis

Thyroid — Tue, 07 Feb 2012 16:55:18 +0100

Thyroid , Vol. 0, No. 0. (Source: Thyroid)

Consecutive Mutational Events in a TSHR Allele of Arab Families with Resistance to Thyroid Stimulating Hormone

Thyroid — Tue, 07 Feb 2012 16:55:16 +0100

Thyroid , Vol. 0, No. 0. (Source: Thyroid)

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Radioiodine Treatment of Metastatic Thyroid Cancer: Relative Efficacy and Side Effect Profile of Preparation by Thyroid Hormone Withdrawal Versus Recombinant Human Thyrotropin

Thyroid — Tue, 07 Feb 2012 16:53:26 +0100

Thyroid , Vol. 0, No. 0. (Source: Thyroid)

Cholesterol Goal Attainment in Hypertensive Patients: The Impact of Metabolic Syndrome Components

Metabolic Syndrome and Related Disorders — Tue, 07 Feb 2012 16:34:32 +0100

Metabolic Syndrome and Related Disorders , Vol. 0, No. 0. (Source: Metabolic Syndrome and Related Disorders)

Hemoglobin A1c, BP With Eye Exam for Diabetic RetinopathyHemoglobin A1c, BP With Eye Exam for Diabetic Retinopathy

Medscape Today Headlines — Tue, 07 Feb 2012 15:19:24 +0100

The Diabetic Retinopathy Clinical Research study continues to yield important information about diabetic retinopathy, macular edema, and associated conditions. More studies are planned. Medscape Medical News (Source: Medscape Today Headlines)

AMPK γ2 subunit gene PRKAG2 polymorphism associated with cognitive impairment as well as diabetes in old age

Psychoneuroendocrinology — Tue, 07 Feb 2012 14:13:24 +0100

Summary: Metabolic and cognitive disorders are closely related. However, the molecular mechanism underlying this association is still elusive. Given the importance of energy metabolism in neuronal cells, AMP-activated protein kinase (AMPK), a master switch of energy metabolism, could be an independent factor affecting cognitive as well as metabolic functions. Therefore, we examined the relationship between the AMPK γ2 gene, the PRKAG2 −26C/T polymorphism and cognitive impairment or diabetes in 1609 subjects aged from 60 to 80. We performed multivariate logistic regression analyses with adjustment for age, gender, education, smoking, alcohol, depression, waist circumference, APOE e4, and stroke history. We found a significant association between the −26C/T polymorphism (CC vs. CT/TT) a...

Transgenic overexpression of keratinocyte-specific VEGF and Ang1 in combination promotes wound healing under nondiabetic but not diabetic conditions.

International Journal of Clinical and Experimental Pathology — Tue, 07 Feb 2012 13:36:02 +0100

Authors: Loyd CM, Diaconu D, Fu W, Adams GN, Brandt E, Knutsen DA, Wolfram JA, McCormick TS, Ward NL Abstract VEGF and Angiopoietin (Ang)1 are growth factors that independently improve wound healing outcomes. Using a tet-repressible mouse model coupled with streptozotocin-induced diabetes, we examined wound healing in diabetic and nondiabetic mice engineered to overexpress keratinocyte-specific (K5) VEGF, Ang1 or Ang1-VEGF combined. All nondiabetic mice healed more rapidly than their diabetic counterparts; however overexpression of VEGF, Ang1 or the combination failed to improve wound closure under diabetic conditions. Conversely, under nondiabetic conditions, combining Ang1 and VEGF resulted in rapid wound closure. Molecular analyses of diabetic and nondiabetic K5-Ang1-VEGF skin r...

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Member of the Endocrinology and Diabetes SCE Examining Board

Society for Endocrinology — Tue, 07 Feb 2012 12:00:00 +0100

The Society for Endocrinology, the Association of British Clinical Diabetologists and the Federation of the Royal Colleges of Physicians of the UK are inviting applications for the above position to commence in 2012. A copy of the remit and responsibilities of the examining board and requirements of potential applicants can be found on the MRCP website. Expressions of interest (in the form of a single side of A4 resume that includes a statement of interest) should be submitted to Abhi Vora (abhi.vora@endocrinology.org) by 30 March 2012. (Source: Society for Endocrinology)

Congratulations

Society for Endocrinology — Tue, 07 Feb 2012 12:00:00 +0100

The Society would like to congratulate Professor Sadaf Farooqi (University of Cambridge) who has been awarded the European Society of Endocrinology EJE Prize for this year. She will give her lecture at the joint 15th International Congress of Endocrinology and 14th European Congress of Endocrinology meeting (ICE/ECE 2012, 5-9 May 2012, Florence). (Source: Society for Endocrinology)

Society membership ? gratis period for payment of membership

Society for Endocrinology — Tue, 07 Feb 2012 12:00:00 +0100

The Society offers a gratis period at the beginning of the subscription year in which you can pay your membership without lapsing. Previously, this period was from January to June. Please note that this gratis period has been revised so that it will now run from January to March. At the end of March, if your membership remains unpaid for that year, your membership will lapse and you will not be eligible to apply for grants and register for SfE events at the members’ discounted rate.SfE membership (Source: Society for Endocrinology)

Researchers develop method of directing stem cells to increase bone formation and bone strength (EurekAlert, 5 February 2012)

Society for Endocrinology — Tue, 07 Feb 2012 12:00:00 +0100

US researchers have developed a technique to promote bone growth in a mouse model of osteoporosis by stimulating the migration of stem cells to the bone, reporting their findings in Nature Medicine. Full article (Source: Society for Endocrinology)

European Competition for Best Innovations in University Outreach and Public Engagement

Society for Endocrinology — Tue, 07 Feb 2012 12:00:00 +0100

As part of the EC-funded ULab project, the Oxford Internet Institute at the University of Oxford is organising an online competition to identify the most innovative outreach and public engagement activities carried out by European Universities. Both individuals and groups may apply for awards. Competition submissions must be for an activity that has been initiated and sustained at any university or higher education institution within the 27 EU member states, including projects that might have involved collaboration with institutions outside the EU. The entry can be from one or a number of cooperating universities. The three winning entries will each receive a 5000 EUR prize for their institution as well as funding for a representative to attend the award ceremony at the University of Oxfo...

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Gene mutation discovery sparks hope for effective endometriosis screening (EurekAlert, 6 February 2012)

Society for Endocrinology — Tue, 07 Feb 2012 12:00:00 +0100

A US study published in EMBO Molecular Medicine investigates a gene which may be linked to endometriosis. Full article (Source: Society for Endocrinology)

Taste Receptors Discovered In Pancreatic Beta Cells Can Sense Fructose And Stimulate Insulin Secretion

Health News from Medical News Today — Tue, 07 Feb 2012 09:00:00 +0100

Taste receptors on the tongue help us distinguish between safe food and food that's spoiled or toxic. But taste receptors are now being found in other organs, too. In a study published online the week of February 6 by the Proceedings of the National Academy of Sciences of the USA, researchers at Sanford-Burnham Medical Research Institute (Sanford-Burnham) discovered that beta cells in the pancreas use taste receptors to sense fructose, a type of sugar. According to the study, the beta cells respond to fructose by secreting insulin, a hormone that regulates the body's response to dietary sugar... (Source: Health News from Medical News Today)

News From The Annals Of Internal Medicine: Feb. 7 2012

Health News from Medical News Today — Tue, 07 Feb 2012 09:00:00 +0100

1. American College of Physicians Issues New Clinical Practice Guideline for Drug Treatment of Type 2 Diabetes ACP Recommends Metformin to Treat Type 2 Diabetes Based on Comparative Effectiveness Analysis of Oral Medications The American College of Physicians (ACP) recommends that clinicians add metformin as the initial drug treatment for most patients with type 2 diabetes when lifestyle modifications such as diet, exercise, and weight loss have failed to adequately improve high blood sugar... (Source: Health News from Medical News Today)

Based On CE Analysis Of Oral Medications, ACP Recommends Metformin To Treat Type 2 Diabetes

Health News from Medical News Today — Tue, 07 Feb 2012 09:00:00 +0100

The American College of Physicians (ACP) recommends that clinicians add metformin as the initial drug treatment for most patients with type 2 diabetes when lifestyle modifications such as diet, exercise, and weight loss have failed to adequately improve high blood sugar. ACP also recommends that clinicians add a second drug to metformin when treatment with metformin and lifestyle changes fail to control blood sugar levels. Citing insufficient evidence, ACP does not recommend one class of drug over another as a second medication... (Source: Health News from Medical News Today)

One In Ten Cases Of Diabetes Goes Untreated

Health News from Medical News Today — Tue, 07 Feb 2012 08:00:00 +0100

Rates of diabetes vary widely across developing countries worldwide, according to a new analysis led by Dr. Longjian Liu of Drexel University's School of Public Health. Worldwide, four in five people with diabetes now live in developing countries. Liu's study found that access to healthcare support for diabetes varied widely in developing countries, and that one in 10 diagnosed cases remain untreated. The study is available online and will appear in a future issue of the journal Diabetic Medicine. "Diabetes is now one of the most common non-communicable diseases globally," Liu said... (Source: Health News from Medical News Today)

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Study: Rapid bone loss as possible side effect of anti-obesity drug now in clinical trials

UT Southwestern Medical Center News — Tue, 07 Feb 2012 07:29:12 +0100

An endocrine hormone used in clinical trials as an anti-obesity and anti-diabetes drug causes significant and rapid bone loss in mice, raising concerns about its safe use, have shown. (Source: UT Southwestern Medical Center News)

Hard-Boiled Egg Recall Hits 34 States

MedicineNet Diabetes General — Tue, 07 Feb 2012 07:00:00 +0100

Title: Hard-Boiled Egg Recall Hits 34 StatesCategory: Health NewsCreated: 2/7/2012 11:00:00 AMLast Editorial Review: 2/7/2012 (Source: MedicineNet Diabetes General)

Even for the Overweight, Exercise Helps the Heart

MedicineNet Diabetes General — Tue, 07 Feb 2012 07:00:00 +0100

Title: Even for the Overweight, Exercise Helps the HeartCategory: Health NewsCreated: 2/7/2012 10:05:00 AMLast Editorial Review: 2/7/2012 (Source: MedicineNet Diabetes General)

Metformin Preferred Drug for Type 2 Diabetes, Experts Say

MedicineNet Diabetes General — Tue, 07 Feb 2012 07:00:00 +0100

Title: Metformin Preferred Drug for Type 2 Diabetes, Experts SayCategory: Health NewsCreated: 2/6/2012 6:06:00 PMLast Editorial Review: 2/7/2012 (Source: MedicineNet Diabetes General)

Pancreas May 'Taste' Fructose, Hinting at Links to Diabetes

MedicineNet Diabetes General — Tue, 07 Feb 2012 07:00:00 +0100

Title: Pancreas May 'Taste' Fructose, Hinting at Links to DiabetesCategory: Health NewsCreated: 2/6/2012 6:06:00 PMLast Editorial Review: 2/7/2012 (Source: MedicineNet Diabetes General)

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Metformin Preferred Drug for Type 2 Diabetes, Experts Say

MedicineNet Cholesterol General — Tue, 07 Feb 2012 07:00:00 +0100

Title: Metformin Preferred Drug for Type 2 Diabetes, Experts SayCategory: Health NewsCreated: 2/6/2012 6:06:00 PMLast Editorial Review: 2/7/2012 (Source: MedicineNet Cholesterol General)

Metastatic Pheochromocytoma and Paraganglioma: Focus on Therapeutics

Hormone and Metabolic Research — Tue, 07 Feb 2012 05:00:00 +0100

Horm Metab ResDOI: 10.1055/s-0031-1299707Metastatic pheochromocytomas and paragangliomas are rare and challenging tumors. The tumor burden, combined with excessive catecholamine production, predispose to a broad spectrum of complications that range from spinal cord compression to any organ damage, all of which may lead to decreased quality of life and overall survival. Current therapies include surgery, systemic chemotherapy and radiopharmaceutical agents. Surgery is often a preferred therapy because it may cure or allow a long-term remission in patients with locoregional or isolated resectable distant metastases. Additionally, surgery can palliate symptoms related to tumor burden or catecholamine excess. However, in patients for whom surgery is not an option, systemic chemotherapy and rad...

Estrogen Plus Estrogen Receptor Antagonists Alter Mineral Production by Osteoblasts In Vitro

Hormone and Metabolic Research — Tue, 07 Feb 2012 05:00:00 +0100

Horm Metab Res 2012; 44: 154-154DOI: 10.1055/s-0032-1305800© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | FREE Full text (Source: Hormone and Metabolic Research)

Postnatal Low Protein Diet Programs Leptin Signaling in the Hypothalamic-Pituitary-Thyroid Axis and Pituitary TSH Response to Leptin in Adult Male Rats

Hormone and Metabolic Research — Tue, 07 Feb 2012 05:00:00 +0100

Horm Metab Res 2012; 44: 114-122DOI: 10.1055/s-0031-1299747Maternal protein restriction (PR) during lactation programs a lower body weight, hyperthyroidism, leptin resistance, and over-expression of leptin receptor in the pituitary gland at adulthood. Because leptin regulates energy homeostasis and the hypothalamus-pituitary-thyroid (HPT) axis, we evaluated adipocyte morphology, the leptin signaling pathway in the HPT axis and the in vitro thyrotropin (TSH) response to leptin in adult progeny in this model. At birth, dams were separated in control diet with 23% protein or PR diet with 8% protein. After weaning, offspring received a normal diet. Adult PR offspring showed lower adipocytes area, higher leptin:visceral fat ratio, lower hypothalamic signal transducer and activator of transc...

How does lifestyle intervention affect depressive symptoms? Results from the Finnish Diabetes Prevention Study

Diabetic Medicine — Tue, 07 Feb 2012 05:00:00 +0100

Conclusions: Participation in the study lowered depression scores, with no specific group effect. Among the lifestyle changes, particularly successful reduction of body weight was associated with the greater reduction of depressive symptoms. Thus, regardless of the intensity of the treatment, the success in executing alterations in one’s lifestyle and behaviour is associated with beneficial changes in mood.© 2012 The Authors. Diabetic Medicine © 2012 Diabetes UK (Source: Diabetic Medicine)

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Type 2 diabetes mellitus in a patient with malignant insulinoma manifesting following surgery

Diabetic Medicine — Tue, 07 Feb 2012 05:00:00 +0100

Conclusions: Although this is a rare condition, clinicians should bear in mind that insulinomas may exist together with diabetes mellitus, and it is important to have this suspicion when considering the perioperative approach and for the prevention of morbidities.© 2012 The Authors. Diabetic Medicine © 2012 Diabetes UK (Source: Diabetic Medicine)

Hypoglycaemia during pregnancy in women with Type 1 diabetes

Diabetic Medicine — Tue, 07 Feb 2012 05:00:00 +0100

Conclusions: Striving for near‐normoglycaemia with focus on reduction of plasma glucose fluctuations during pregnancy should have high priority among clinicians with the persistent aim of improving pregnancy outcome among women with Type 1 diabetes. Pre‐conception counselling, carbohydrate counting, use of insulin analogues, continuous subcutaneous insulin infusion (insulin pump) therapy and real‐time continuous glucose monitoring with alarms for low glucose values might be relevant tools to obtain near‐normoglycaemia without episodes of severe hypoglycaemia.© 2012 The Authors. Diabetic Medicine © 2012 Diabetes UK (Source: Diabetic Medicine)

Insulin adherence behaviours and barriers in the multinational Global Attitudes of Patients and Physicians in Insulin Therapy study

Diabetic Medicine — Tue, 07 Feb 2012 05:00:00 +0100

Conclusions: Glucose control is inadequate among insulin‐treated patients, in part attributable to insulin omission/non‐adherence and lack of dose adjustment. There is a need for insulin regimens that are less restrictive and burdensome with lower risk of hypoglycaemia.© 2012 The Authors. Diabetic Medicine © 2012 Diabetes UK (Source: Diabetic Medicine)

The cost of diagnosing Type 2 diabetes mellitus by clinical opportunistic screening in general practice

Diabetic Medicine — Tue, 07 Feb 2012 05:00:00 +0100

Conclusions: Almost two‐thirds of new cases of Type 2 diabetes can be detected before symptoms are reported, at reasonable cost by opportunistic screening in general practice, without the use of extra resources. As an affordable alternative to population screening, clinical opportunistic screening merits further consideration.© 2012 The Authors. Diabetic Medicine © 2012 Diabetes UK (Source: Diabetic Medicine)

Metabolic abnormalities associated with initiation of systemic treatment for psoriasis: evidence from the Italian Psocare Registry

Journal of the European Academy of Dermatology and Venereology — Tue, 07 Feb 2012 05:00:00 +0100

Conclusion Systemic treatments for psoriasis resulted in heterogeneous effects on the parameters analysed. (Source: Journal of the European Academy of Dermatology and Venereology)

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Efficacy and Safety of Dextromethorphan/Quinidine at Two Dosage Levels for Diabetic Neuropathic Pain: A Double‐Blind, Placebo‐Controlled, Multicenter Study

Pain Medicine — Tue, 07 Feb 2012 05:00:00 +0100

Conclusions. Throughout a 13‐week trial, DMQ was effective, with an acceptable safety profile, for treatment of DPN pain. Other fixed‐dose combinations of DMQ should be studied to improve overall tolerability while maintaining significant efficacy. (Source: Pain Medicine)

Top off breakfast with -- chocolate cake?

EurekAlert! - Medicine and Health — Tue, 07 Feb 2012 05:00:00 +0100

(American Friends of Tel Aviv University) In a study of nearly 200 clinically obese, non-diabetic adults, professor Daniela Jakubowicz of Tel Aviv University found that a 600-calorie breakfast that includes dessert as well as proteins and carbohydrates can help dieters lose weight and keep it off over the long term. Her research indicates that such a morning meal staves off cravings and defuses psychological addictions to sweet foods. (Source: EurekAlert! - Medicine and Health)

Counties with thriving small businesses have healthier residents, LSU and Baylor researchers find

EurekAlert! - Social and Behavioral Science — Tue, 07 Feb 2012 05:00:00 +0100

(Baylor University) Counties and parishes with a greater concentration of small, locally-owned businesses have healthier populations -- with lower rates of mortality, obesity and diabetes -- than do those that rely on large companies with "absentee" owners, according to a national study by sociologists at LSU and Baylor University. (Source: EurekAlert! - Social and Behavioral Science)

Sixth International Symposium on Diabetes and PregnancySixth International Symposium on Diabetes and Pregnancy

Medscape Today Headlines — Tue, 07 Feb 2012 04:00:00 +0100

Read about new recommendations for diagnosing gestational diabetes mellitus. The British Journal of Diabetes and Vascular Disease (Source: Medscape Today Headlines)

VEGF Inhibitors in the Management of Diabetic Macular EdemaVEGF Inhibitors in the Management of Diabetic Macular Edema

Medscape Today Headlines — Tue, 07 Feb 2012 04:00:00 +0100

This new study takes a look at whether VEGF inhibitors are a viable alternative to other options, such as photocoagulation, in the treatment of diabetic macular edema. The British Journal of Ophthalmology (Source: Medscape Today Headlines)

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Pattern of adrenal morphology and function in patients with acromegaly

European Journal of Clinical Investigation — Tue, 07 Feb 2012 02:06:19 +0100

Conclusions This study provides evidence of an increased prevalence of anatomic and functional adrenal alterations in patients with acromegaly; further studies will clarify the importance of evaluating these subjects with baseline hormonal investigation along with dynamic testing and modified cut‐offs. (Source: European Journal of Clinical Investigation)

Visit‐to‐visit variability in blood pressure strongly predicts all‐cause mortality in patients with type 2 diabetes: a 5·5‐year prospective analysis

European Journal of Clinical Investigation — Tue, 07 Feb 2012 02:06:11 +0100

Conclusions Visit‐to‐visit variability in blood pressure was significantly associated with all‐cause mortality independent of mean BP in patients with type 2 diabetes. The data for blood pressure variability might be regarded as a potentially important therapeutic target in the management of type 2 diabetes. (Source: European Journal of Clinical Investigation)

Child Abuse Linked to High Financial BurdenChild Abuse Linked to High Financial Burden

Medscape Today Headlines — Tue, 07 Feb 2012 01:40:38 +0100

Lifetime medical costs for abused kids outstrip those for type 2 diabetes and stroke. Medscape Medical News (Source: Medscape Today Headlines)

Chocolate and cocoa may improve heart health

MedWire News - Diabetes — Tue, 07 Feb 2012 00:00:00 +0100

Chocolate and cocoa consumption may have beneficial effects on cardiovascular health, research suggests. (Source: MedWire News - Diabetes)

Predictors for good glycemic control, low HbA1c identified

MedWire News - Diabetes — Tue, 07 Feb 2012 00:00:00 +0100

Researchers have identified a number of predictors – including age and medication adherence – for good glycemic control and low glycated hemoglobin concentrations among patients with suboptimally controlled Type 2 diabetes. (Source: MedWire News - Diabetes)

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Positive attitude reduces relapse after continuous insulin infusion

MedWire News - Diabetes — Tue, 07 Feb 2012 00:00:00 +0100

Patients with newly diagnosed Type 2 diabetes who receive short-term intensive insulin treatment can increase their likelihood for achieving long-term drug-free remission if they adopt a positive attitude toward their condition and are confident about their care ability, suggest study findings. (Source: MedWire News - Diabetes)

Defeminization of Brain Functions by a Single Injection of Estrogen Receptor α or β Agonist in Neonatal Female Rats

Neuroendocrinology — Mon, 06 Feb 2012 23:00:00 +0100

Neuroendocrinology (DOI:10.1159/000332128) (Source: Neuroendocrinology)

The Novel WHO 2010 Classification for Gastrointestinal Neuroendocrine Tumours Correlates Well with the Metastatic Potential of Rectal Neuroendocrine Tumours

Neuroendocrinology — Mon, 06 Feb 2012 23:00:00 +0100

Neuroendocrinology (DOI:10.1159/000333035) (Source: Neuroendocrinology)

Infusion of a Lipid Emulsion in Healthy Men Decreases the Serotonergic Response

Neuroendocrinology — Mon, 06 Feb 2012 23:00:00 +0100

Neuroendocrinology (DOI:10.1159/000333038) (Source: Neuroendocrinology)

Differential Ontogenetic Patterns of in vitro Desensitization to GHRH in Fetal and Neonatal Anterior Pituitary

Neuroendocrinology — Mon, 06 Feb 2012 23:00:00 +0100

Neuroendocrinology (DOI:10.1159/000333779) (Source: Neuroendocrinology)

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Involvement of α2-Adrenoceptor Subtypes A and C in Glucose Homeostasis and Adrenaline-Induced Hyperglycaemia

Neuroendocrinology — Mon, 06 Feb 2012 23:00:00 +0100

Neuroendocrinology (DOI:10.1159/000334629) (Source: Neuroendocrinology)

Self-Monitoring Not Helpful for Type 2 DiabetesSelf-Monitoring Not Helpful for Type 2 Diabetes

Medscape Today Headlines — Mon, 06 Feb 2012 22:29:37 +0100

In patients with non-insulin- dependent diabetes, self-monitoring of blood glucose had only a modest effect on HbA1c levels at six 6 months. Medscape Medical News (Source: Medscape Today Headlines)

ACP Guideline Addresses Pharmacotherapy of Type 2 DiabetesACP Guideline Addresses Pharmacotherapy of Type 2 Diabetes

Medscape Today Headlines — Mon, 06 Feb 2012 22:09:31 +0100

The ACP recommends metformin as the initial drug for most patients with type 2 diabetes when lifestyle modifications are not enough to control blood sugar levels. A second drug can be added if needed. Medscape Medical News (Source: Medscape Today Headlines)

Type 2 Diabetes Therapy Subject of New ACP GuidelineType 2 Diabetes Therapy Subject of New ACP Guideline

Medscape Today Headlines — Mon, 06 Feb 2012 22:09:31 +0100

Pancreas May 'Taste' Fructose, Hinting at Links to Diabetes

MedlinePlus Health News — Mon, 06 Feb 2012 22:00:00 +0100

High-fructose corn syrup is ubiquitous in Western diet, and study suggests it could play unique role Source: HealthDay Related MedlinePlus Pages: Carbohydrates, Diabetes Type 2 (Source: MedlinePlus Health News)

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Metformin Preferred Drug for Type 2 Diabetes, Experts Say

MedlinePlus Health News — Mon, 06 Feb 2012 22:00:00 +0100

But, American College of Physicians states diet and exercise changes should start before medicationSource: HealthDay Related MedlinePlus Pages: Diabetes Medicines, Diabetes Type 2 (Source: MedlinePlus Health News)

Postural Strategies in Diabetes Patients with Peripheral Neuropathy Determined Using Cross-Correlation Functions

Diabetes Technology — Mon, 06 Feb 2012 21:52:54 +0100

Diabetes Technology & Therapeutics , Vol. 0, No. 0. (Source: Diabetes Technology)

Discrepancies Between Reported Self-Monitored Blood Glucose Results and Point-of-Care Hemoglobin A1c in Children with Diabetes: Lessons to Be Learned

Diabetes Technology — Mon, 06 Feb 2012 21:52:52 +0100

Diabetes Technology & Therapeutics , Vol. 0, No. 0. (Source: Diabetes Technology)

Altered Intestinal P-glycoprotein Expression Levels Affect Pharmacodynamics under Diabetic Condition.

Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan — Mon, 06 Feb 2012 21:06:03 +0100

In conclusions, our findings suggest that the oral morphine analgesia is dependent on intestinal P-gp expression, and that may be one of the problems against obtaining stable pharmacological effects of morphine in diabetic patients. PMID: 22293693 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)

Guideline: Diabetes Treatment Should Start with Metformin (CME/CE)

MedPage Today Cardiovascular — Mon, 06 Feb 2012 21:00:00 +0100

(MedPage Today) -- Metformin should be the first-line choice in oral therapy for type 2 diabetics who don't respond to diet and lifestyle changes, according to a new guideline. (Source: MedPage Today Cardiovascular)

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Tasting Fructose With the Pancreas

Diabetes News from dLife.com — Mon, 06 Feb 2012 20:08:40 +0100

February 6, 2012 (Sanford Burnham Medical Research Institute) — Sanford-Burnham researchers discover taste receptors in pancreatic beta cells that can sense fructose and stimulate insulin secretion. read more (Source: Diabetes News from dLife.com)

Positive Parenting During Early Childhood May Prevent Obesity

Diabetes News from dLife.com — Mon, 06 Feb 2012 15:26:46 +0100

February 6, 2012 (Newswise) — Programs that support parents during their child’s early years hold promise for obesity prevention, according to a new study in the online February 6 issue of Pediatrics. read more (Source: Diabetes News from dLife.com)

Sympathetic Blocks Provided Sustained Pain Relief in a Patient with Refractory Painful Diabetic Neuropathy

Comparative and Functional Genomics — Mon, 06 Feb 2012 14:15:44 +0100

The sympathetic nervous system has been implicated in pain associated with painful diabetic neuropathy. However, therapeutic intervention targeted at the sympathetic nervous system has not been established. We thus tested the hypothesis that sympathetic nerve blocks significantly reduce pain in a patient with painful diabetic neuropathy who has failed multiple pharmacological treatments. The diagnosis of small fiber sensory neuropathy was based on clinical presentations and confirmed by skin biopsies. A series of 9 lumbar sympathetic blocks over a 26-month period provided sustained pain relief in his legs. Additional thoracic paravertebral blocks further provided control of the pain in the trunk which can occasionally be seen in severe diabetic neuropathy cases, consequent to extensive inv...

Working Out in Thin Air Helps Diabetics (CME/CE)

MedPage Today Cardiovascular — Mon, 06 Feb 2012 13:38:32 +0100

(MedPage Today) -- Exercising for one straight hour in hypoxic conditions improves glycemic control among patients with type 2 diabetes, researchers found. (Source: MedPage Today Cardiovascular)

Free online journal access for SfE members

Society for Endocrinology — Mon, 06 Feb 2012 12:00:00 +0100

Don’t forget that members of the Society for Endocrinology receive FREE online access to the current content of Society journals, Journal of Endocrinology, Journal of Molecular Endocrinology, Endocrine-Related Cancer, and to the Society’s official clinical journal, Clinical Endocrinology, published by Wiley-Blackwell, as part of their membership fee. Members can access all the journals online via BioSciAlliance. Members should log on using their membership number and same password used to access the SfE Members’ secure area. If you require any further assistance, please contact members@endocrinology.org. If you are not a member you can still sign up for our free Table of Contents alerting service. (Source: Society for Endocrinology)

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Endocrine Nurses' session at ICE/ECE 2012

Society for Endocrinology — Mon, 06 Feb 2012 12:00:00 +0100

The 15th International Congress of Endocrinology and 14th European Congress of Endocrinology, ICE/ECE 2012, will take place in Florence from 5-9 May 2012. At the conference, there are two morning clinical sessions and one evening professional development session scheduled for nurses, where there will also be an opportunity to present your work in a poster presentation and network with other colleagues from around the world. The Best Nursing Poster Prize winner will also be announced during the evening session The congress registration fees for nurses have been substantially reduced to just ?100. This is an introductory registration fee on offer to all nurse attendees whether or not you are a member of the European Society of Endocrinology. Click on the link below to view the full progra...

Diabetes quadruples birth defects risk, say researchers (BBC News Online, 6 February 2012)

Society for Endocrinology — Mon, 06 Feb 2012 12:00:00 +0100

A UK study published in Diabetologia examines the risk of bearing a child with a birth defect in mothers with and without diabetes (type 1 or 2). Full article (Source: Society for Endocrinology)

Assistant Professor in animal epigenetics and stress physiology, University of California

Society for Endocrinology — Mon, 06 Feb 2012 12:00:00 +0100

The University of California, Davis is pleased to announce recruitment for a tenure-track faculty position in animal epigenetics and stress physiology. The successful candidate will join the Department of Animal Science in the College of Agricultural and Environmental Sciences at the rank of Assistant Professor. Criteria for appointment include: a PhD or equivalent; a strong interest in improving sustainable animal production by understanding how environmental, nutritional, hormonal, and behavioural stressors interact with gene expression; a record of excellence in scholarly research; and demonstrable potential to establish a competitively-funded research program relevant to animal stress in sustainable animal agriculture. The appointee will be responsible for teaching an undergraduate c...

L?Or?al-UNESCO Fellowships for Women in Science 2012

Society for Endocrinology — Mon, 06 Feb 2012 12:00:00 +0100

L’Oréal UK and Ireland, the UK National Commission for UNESCO and the Irish National Commission for UNESCO, with the support of the Royal Society have partnered together to provide a dedicated UK and Ireland For Women In Science Fellowship Programme for women scientists at postdoctoral level to enable and/or facilitate promising scientific research in the life or physical sciences. Four Fellowships will be awarded in 2012 to outstanding female postdoctoral scientists to assist them with their research. The Fellowships, each worth £15,000 (equivalent ? for candidates in Ireland), are tenable at any UK or Irish university or research institute to support a 12-month period of research. The fellowship money can be spent in any number of innovative ways to enable women scientis...

MRes/PhD Studentship: The contribution of lysine methylases to androgen receptor function in advanced prostate cancer

Society for Endocrinology — Mon, 06 Feb 2012 12:00:00 +0100

Newcastle University have opened applications for a MRs/PhD studentship in 'The contribution of lysine methylases to androgen receptor function in advanced prostate cancer'. Prostate cancer is the leading cause of cancer-associated deaths in men in the Western world and accounts for approximately 10,000 deaths in the UK. At presentation, prostate cancer growth is androgen-dependent hence the mainstay for treatment is androgen-ablation therapy that block androgen production or action. Unfortunately, after a median time of 18 months, the cancer re-appears in an androgen-independent form, termed castrate-resistant prostate cancer, which is untreatable. This studentship will assess the effectiveness of the lysine methylase proteins in prostate cancer using both in vitro assays and cell line m...

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SfE BES 2012 - early bird registration - 13 February 2012

Society for Endocrinology — Mon, 06 Feb 2012 12:00:00 +0100

SfE BES 2012 will take place in Harrogate from 19-22 March 2012. Reduced registration rates are available for SfE members and non-members registering before the early bird deadline of 13 February 2012. Click on the link below to register now! SfE BES 2012 registration (Source: Society for Endocrinology)

SfE-sponsored Biology Undergraduate Research Bursaries

Society for Endocrinology — Mon, 06 Feb 2012 12:00:00 +0100

The Biology Undergraduate Research Bursaries Programme is run by the Society of Biology in conjunction with the Society for Endocrinology and other learned societies. The purpose of the awards is to give experience of research to undergraduates with research potential and to encourage them to consider a career in scientific research. The awards provide support for the student at a rate of £180 per week, for a period of between six and eight weeks. Researchers in the biological and biomedical sciences at universities and research institutions within the UK are eligible to apply. Click on the link below for further details, eligibility criteria and to download an application form. The closing date for receipt of applications is 5pm Friday 30 March 2012. Society of Biology: Bi...

Elevated Glucose Associated With Undetected Heart Damage

Health News from Medical News Today — Mon, 06 Feb 2012 08:00:00 +0100

A new study led by researchers at the Johns Hopkins Bloomberg School of Public Health suggests that hyperglycemia (high blood sugar) injures the heart, even in patients without a history of heart disease or diabetes. Researchers found that elevated levels of glycated hemoglobin (HbA1c), a marker for chronic hyperglycemia and diabetes, were associated with minute levels of the protein troponin T (cTnT), a blood marker for heart damage. The high-sensitivity test they used detected levels of cTnT tenfold lower than those found in patients diagnosed with a heart attack... (Source: Health News from Medical News Today)

Can sugar really be toxic? Sadly, yes

Telegraph Health — Mon, 06 Feb 2012 07:30:50 +0100

Eating excessive amounts of processed sugar is leading to an epidemic in type 2 diabetes, finds Max Pemberton. (Source: Telegraph Health)

Diabetes Takes Toll on Women's Hearing: Study

MedicineNet Diabetes General — Mon, 06 Feb 2012 07:00:00 +0100

Title: Diabetes Takes Toll on Women's Hearing: StudyCategory: Health NewsCreated: 2/3/2012 4:06:00 PMLast Editorial Review: 2/6/2012 (Source: MedicineNet Diabetes General)

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Epidural Plus Fever in Mom May Raise Risks for Baby

MedicineNet Diabetes General — Mon, 06 Feb 2012 07:00:00 +0100

Title: Epidural Plus Fever in Mom May Raise Risks for BabyCategory: Health NewsCreated: 2/3/2012 4:06:00 PMLast Editorial Review: 2/6/2012 (Source: MedicineNet Diabetes General)

Reversing the Irreversible - discover how 37 people cured diabetes, cancer, eczema, IBS, high blood pressure and more

NaturalNews.com — Mon, 06 Feb 2012 06:00:00 +0100

Valya Boutenko's newest film release reveals the true story of how 37 people reversed so-called "incurable" disease by unleashing their innate healing powers. Flying in the face of conventional medical wisdom -- which really isn't wise at all -- this film celebrates... (Source: NaturalNews.com)

Neuronal transplants for treatment of obesity

Scientific American - Official RSS Feed — Mon, 06 Feb 2012 05:58:00 +0100

There are many different factors which go into whether animals (or humans) develop obesity and diabetes. Different sensitivity to different chemicals, in different areas of the body and brain, can cause major differences in feeding behavior, body weight, fat, and insulin sensitivity. And now we’ve learned that changes in one circuit of the hypothalamus could make a big difference in a certain kind of obesity in mice. [More] (Source: Scientific American - Official RSS Feed)

Hormonal, functional and genetic biomarkers in controlled ovarian stimulation: tools for matching patients and protocols

Reproductive Biology and Endocrinology — Mon, 06 Feb 2012 05:00:00 +0100

Variability in the subfertile patient population excludes the possibility of a single approach to controlled ovarian stimulation (COS) covering all the requirements of a patient. Modern technology has led to the development of new drugs, treatment options and quantitative methods that can identify single patient characteristics. These could potentially be used to match patients with the right treatment options to optimise efficacy, safety and tolerability during COS. Currently, age and follicle-stimulating hormone (FSH) level remain the most commonly used single patient characteristics in clinical practice. These variables only provide a basic prognosis for success and indications for standard COS treatment based on gross patient categorisation. In contrast, the anti-Mullerian hormone leve...

The relationship between polycystic ovary syndrome, glucose tolerance status and serum preptin level

Reproductive Biology and Endocrinology — Mon, 06 Feb 2012 05:00:00 +0100

Conclusions: Irrespective of PCOS status, women with IGT had higher serum preptin levels compared with women with NGT. Preptin levels are related with glucose tolerance status, but not with PCOS status. (Source: Reproductive Biology and Endocrinology)

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Hyberbaric oxygen increases atresia in normal & steroid induced PCO rat ovaries

Reproductive Biology and Endocrinology — Mon, 06 Feb 2012 05:00:00 +0100

Conclusions: HBOT of six weeks itself, changed ovarian morphology in favor of atresia both in PCO group and control group. This result of aggravated follicular atresia after HBOT on EV induced PCO may be due to long-term exposure in our protocol which with this state seems to be inapplicable in the improvement of PCO morphology. (Source: Reproductive Biology and Endocrinology)

Sexual Behaviour and Neuronal Activation in the Vomeronasal Pathway and Hypothalamus of Food‐Deprived Male Rats

Journal of Neuroendocrinology — Mon, 06 Feb 2012 05:00:00 +0100

AbstractAs feeding and mating are mutually‐exclusive goal‐orientated behaviours, we investigated whether brief food deprivation would impair the display of sexual behaviour of male rats. Analysis of performance in a sexual incentive motivation test revealed that, like fed males, food‐deprived males preferred spending time in the vicinity of receptive females rather than non‐receptive females. Despite this, food‐deprived males were more likely to be slow to mate than normally‐fed males, and a low dose of the satiety peptide α‐melanocyte‐stimulating‐hormone attenuated the effect of hunger. Using Fos immunocytochemistry, we compared neuronal activity in the vomeronasal projection pathway in response to oestrous cues from receptive females between food‐deprived and fed mal...

Chronic Cocaine Exposure During Pregnancy Increases Postpartum Neuroendocrine Stress Responses

Journal of Neuroendocrinology — Mon, 06 Feb 2012 05:00:00 +0100

AbstractThe cycle of chronic cocaine (CC) use and withdrawal results in increased anxiety, depression and disrupted stress‐responsiveness. Oxytocin and corticosterone (CORT) interact to mediate hormonal stress responses and can be altered by cocaine use. These neuroendocrine signals play important regulatory roles in a variety of social behaviours, specifically during the postpartum period, and are sensitive to disruption by CC exposure in both clinical settings and preclinical models. To determine whether CC exposure during pregnancy affected behavioural and hormonal stress response in the early postpartum period in a rodent model, Sprague‐Dawley rats were administered cocaine daily (30 mg/kg) throughout gestation (days 1‐20). Open field test (OFT) and forced swim test (FST) behavio...

Effect of narrow‐band UVB therapy on inflammatory markers and body fat composition in moderate to severe psoriasis

British Journal of Dermatology — Mon, 06 Feb 2012 05:00:00 +0100

Conclusions: We characterised inflammatory and atherogenic profiles of Spanish psoriasis patients compared to matched controls. After NBUVB therapy we demonstrated improvement in psoriasis and some systemic inflammation markers, which were not mediated by enhancement of vitamin D synthesis. (Source: British Journal of Dermatology)

Glycated hemoglobin and associated risk factors in older adults

Cardiovascular Diabetology — Mon, 06 Feb 2012 05:00:00 +0100

Conclusions: Older women had higher HbA1c than men, even after controlling for BMI. HbA1c associates equally with BW, BMI or WC. Population-based criteria are recommended to classify obesity and to identify higher levels of HbA1c in obese older adults. HbA1c associates with atherogenic dyslipidemia particularly with TG and TG/HDL-C ratio, but not with TC, HDL-C, or LDL-C. HbA1c is not associated with hs-CRP, and with functional fitness and aerobic endurance. (Source: Cardiovascular Diabetology)

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Case fatality rates for South Asian and Caucasian patients show no difference 2.5 years after percutaneous coronary intervention

Heart — Mon, 06 Feb 2012 05:00:00 +0100

Conclusion In this large PCI cohort, the in-hospital and longer-term mortality of South Asians appeared no worse than that of Caucasians. South Asians had higher rates of restenosis and CABG during follow-up. Data suggest that the excess coronary mortality for South Asians compared with Caucasians is not explained by differences in case-fatality rates. (Source: Heart)

Cardioprotection against ischaemia induced by dobutamine stress using glucagon-like peptide-1 in patients with coronary artery disease

Heart — Mon, 06 Feb 2012 05:00:00 +0100

Conclusion Intravenous infusion of GLP-1 protects the heart from ischaemic LV dysfunction induced by dobutamine stress in patients with CAD. Clinical trial registration URL: http://isrctn.org. Registration number ISRCTN 69686930. (Source: Heart)

Prediction models for the risk of cardiovascular disease in patients with type 2 diabetes: a systematic review

Heart — Mon, 06 Feb 2012 05:00:00 +0100

Conclusion Many cardiovascular risk scores are available that can be applied to patients with type 2 diabetes. A minority of these risk scores has been validated and tested for its predictive accuracy, with only a few showing a discriminative value of ≥0.80. The impact of applying these risk scores in clinical practice is almost completely unknown, but their use is recommended in various national guidelines. (Source: Heart)

A Pharmacist Care Program: Positive Impact on Cardiac Risk in Patients With Type 2 Diabetes

Journal of Cardiovascular Pharmacology and Therapeutics — Mon, 06 Feb 2012 05:00:00 +0100

Conclusion: The pharmacist care program implemented in this study demonstrated a significant cardiovascular risk reduction in type 2 diabetic patients; therefore such a program would be a valuable addition to a multidisciplinary care of diabetic patients. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)

In Vitro Evidence for Chronic Alcohol and High Glucose Mediated Increased Oxidative Stress and Hepatotoxicity

Alcoholism: Clinical and Experimental Research — Mon, 06 Feb 2012 05:00:00 +0100

ConclusionsThe combined oxidative insult due to alcohol plus high glucose leads to greater liver injury, which may prove to be a timely warning for the injurious effects of alcohol consumption in diabetics. (Source: Alcoholism: Clinical and Experimental Research)

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A team of CRCHUM researchers paves the way for improving treatment for Type 2 diabetes

EurekAlert! - Medicine and Health — Mon, 06 Feb 2012 05:00:00 +0100

(Centre hospitalier de l'Université de Montréal) In a study published last week in Proceedings of the National Academy of Sciences, a team led by Dr. Vincent Poitout of the University of Montreal Hospital Research Centre has made an important step forward in understanding how insulin secretion is regulated in the body. This discovery has important implications for drugs currently in development to treat Type 2 diabetes, a disease which is diagnosed every 10 seconds somewhere throughout the world. (Source: EurekAlert! - Medicine and Health)

Study: Rapid bone loss as possible side effect of anti-obesity drug now in clinical trials

EurekAlert! - Medicine and Health — Mon, 06 Feb 2012 05:00:00 +0100

(UT Southwestern Medical Center) An endocrine hormone used in clinical trials as an anti-obesity and anti-diabetes drug causes significant and rapid bone loss in mice, raising concerns about its safe use, UT Southwestern Medical Center researchers have shown. (Source: EurekAlert! - Medicine and Health)

Anticoagulatory and Antiinflammatory Effects of Astaxanthin in Diabetic Rats

Journal of Food Science — Mon, 06 Feb 2012 05:00:00 +0100

Abstract: Astaxanthin at 0.01 or 0.05% of the diet was supplied to diabetic rats for 12 wk. Astaxanthin intake significantly increased its deposit in plasma, and retained glutathione content, reduced the production of reactive oxygen species, interleukin‐6, tumor necrosis factor‐α, and monocyte chemoattractant protein‐1 in blood and kidney of diabetic rats (P < 0.05). Astaxanthin treatments also significantly decreased plasma levels of C‐reactive protein and von Willebrand factor in diabetic rats (P < 0.05). Astaxanthin intake at 0.05% significantly diminished plasminogen activator inhibitor‐1 and factor VII activities, enhanced antithrombin‐III and protein C activities in circulation (P < 0.05). These results support that astaxanthin could attenuate diabetes assoc...

Donation opens new opportunities for more effective diabetes treatment

EurekAlert! - Medicine and Health — Mon, 06 Feb 2012 05:00:00 +0100

(Karolinska Institutet) The Swedish medical university, Karolinska Institutet, has received a grant of 1.6 million euros from the Stichting af Jochnick Foundation for research into the fundamental causes of diabetes. The grant will make it possible to use unique methods to study how the release of insulin is regulated in living organisms -- and this will create new opportunities for developing more effective drugs against diabetes. (Source: EurekAlert! - Medicine and Health)

Fracture Risk and BMD Reduction Associated With PPIsFracture Risk and BMD Reduction Associated With PPIs

Medscape Today Headlines — Mon, 06 Feb 2012 04:00:00 +0100

This review summarizes bone risk associated with prolonged PPI therapy. Pharmacotherapy (Source: Medscape Today Headlines)

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Meta-analysis of the clinical effect of ligustrazine on diabetic nephropathy.

The American Journal of Chinese Medicine — Mon, 06 Feb 2012 03:06:02 +0100

Authors: Wang B, Ni Q, Wang X, Lin L Abstract Ligustrazine, a bioactive component contained in Chuanxiong (Ligusticum chuanxiong Hort), is widely applied in the treatment of vascular diseases in China, e.g. myocardial and cerebral infarction. The aim of this study was to perform a meta-analysis of randomized controlled trials (RCTs) to evaluate the clinical effect of Ligustrazine on diabetic nephropathy (DN). PUBMED, EMBASE, the Cochrane Central Register of Controlled Trials (CENTRAL), Chinese Biological Medicine Database (CBM), China National Knowledge Infrastructure (CNKI) Database, etc. were searched by computer and manual methods to identify RCTs that were used to evaluate the clinical effect of Ligustrazine on DN patients. Twenty five studies comprising 25 RCTs were involved i...

Antioxidant and Anti-Inflammatory Effects of a Hypoglycemic Fraction from Cucurbita ficifolia Bouché in Streptozotocin-Induced Diabetes Mice.

The American Journal of Chinese Medicine — Mon, 06 Feb 2012 03:06:02 +0100

Authors: Roman-Ramos R, Almanza-Perez JC, Fortis-Barrera A, Angeles-Mejia S, Banderas-Dorantes TR, Zamilpa-Alvarez A, Diaz-Flores M, Jasso I, Blancas-Flores G, Gomez J, Alarcon-Aguilar FJ Abstract Type 2 diabetes is characterized by oxidative stress and a chronic low-grade inflammatory state, which also play roles in the pathogenesis of this disease and the accompanying vascular complications by increasing the production of free radicals and pro-inflammatory cytokines. Cucurbita ficifolia Bouché (C. ficifolia) is an edible Mexican plant whose hypoglycemic activity has been demonstrated in several experimental and clinical conditions. Recently, D-chiro-inositol has been proposed as the compound responsible for the hypoglycemic effects; however, the antioxidant and anti-inflammatory...

Mulberry Leaf Extract Stimulates Glucose Uptake and GLUT4 Translocation in Rat Adipocytes.

The American Journal of Chinese Medicine — Mon, 06 Feb 2012 03:06:02 +0100

Authors: Naowaboot J, Pannangpetch P, Kukongviriyapan V, Prawan A, Kukongviriyapan U, Itharat A Abstract Mulberry (Morus alba L.) leaf tea is promoted for its health benefits and the control of diabetes in Asian nations. The blood glucose lowering activity of mulberry leaf extract (MA) has been proven; however, the molecular basis underlying this effect remains unclear. The aim of the present work is to elucidate its mechanism of the antihyperglycemic action, by examining the effect of MA on glucose uptake and the translocation of glucose transporter 4 protein (GLUT4) to the plasma membrane of adipocytes isolated from diabetic rats. The incubation of adipocytes with 5-45 μg/ml MA resulted in 31-54% increase of glucose uptake in a dose-dependent manner. This glucose uptake enhancin...

'Birth defect risk' for diabetics

BBC News | Health | UK Edition — Mon, 06 Feb 2012 02:10:25 +0100

The risk of birth defects increases four-fold if the pregnant mother has diabetes, a study of 400,000 pregnancies in England suggests. (Source: BBC News | Health | UK Edition)

Diabetes 'ups birth defect risk'

BBC News | Health | UK Edition — Mon, 06 Feb 2012 02:10:25 +0100

The risk of birth defects increases four-fold if the pregnant mother has diabetes, a study of 400,000 pregnancies in England suggests. (Source: BBC News | Health | UK Edition)

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Aging reduces left atrial performance during adrenergic stress in middle aged and older patients.

Cardiology Journal — Mon, 06 Feb 2012 00:36:02 +0100

Conclusions: Age is associated with a decrease in LA function during adrenergic stress even after adjusting for co-morbidities associated with cardiovascular disease and LV function. (Cardiol J 2012; 19, 1: 45-52). PMID: 22298167 [PubMed - in process] (Source: Cardiology Journal)

Zolmitriptan-induced acute myocardial infarction.

Cardiology Journal — Mon, 06 Feb 2012 00:36:02 +0100

We present the case of a 45 year-old woman with a history of migraine with visual aura since the age of 20. She had no history of diabetes mellitus, hypertension, smoking or any other risk factors for cardiovascular events before she was admitted to our emergency room with typical chest pain. An electrocardiogram revealed anterior myocardial infarction following her monthly dose of oral zolmitriptan. Catherization revealed a normal coronary arterial system. The laboratory indices for cardiac risk were within normal ranges. The patient was advised to avoid triptans permanently on being discharged. (Cardiol J 2012; 19, 1: 76-78). PMID: 22298171 [PubMed - in process] (Source: Cardiology Journal)

Women with diabetes warned to take precautions when having a baby

Guardian Unlimited Science — Mon, 06 Feb 2012 00:01:04 +0100

Diabetic mothers-to-be have high risk of giving birth to children with congenital abnormality, study saysWomen who have diabetes are almost four times more likely to have a baby with a birth defect, research reveals.One out of 13 mothers-to-be with either Type 1 or Type 2 of the disease on giving birth have a child with a major congenital abnormality as a direct result of their condition. Overall for such women, the risk of having a child with a birth defect of whatever kind is 7%, according to the journal Diabetologia. The risk of having a baby who has a birth defect is 2% in females without diabetes.Researchers led by Ruth Bell from Newcastle University reached their conclusions after studying 401,149 single-baby pregnancies between 1996 and 2008 in the north of England, 1,677 of them pr...

Long-acting insulin analogs recommended for OHA-resistant diabetes

MedWire News - Diabetes — Mon, 06 Feb 2012 00:00:00 +0100

Patients with Type 2 diabetes who derive no therapeutic benefit from oral hypoglycemic agents may benefit from treatment with long-acting insulin analogs, suggest study findings. (Source: MedWire News - Diabetes)

Ethnicity modifies link between HbA1c and FPG in Asian populations

MedWire News - Diabetes — Sun, 05 Feb 2012 19:41:56 +0100

The use of glycated hemoglobin in place of fasting plasma glucose as an indicator for glycemic status will reclassify Asian individuals’ diabetes status differently depending on their ethnicity, show study findings. (Source: MedWire News - Diabetes)

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Attenuating effect of seeds of Adenanthera pavonina aqueous extract in neuropathic pain in streptozotocin-induced diabetic rats: an evidence of neuroprotective effects

Revista Brasileira de Farmacognosia — Sun, 05 Feb 2012 18:30:49 +0100

The aim of present study was to investigate the attenuating effects of Adenanthera pavonina L., Leguminosae-Mimosaceae seeds aqueous extract (APSAE), in streptozotocin (STZ)-induced diabetic neuropathy in rats. APSAE (50, 100 and 200 mg/kg per day) was given to diabetic rats for twelve weeks. Cold and hot water tail immersion tests, photoactometer and Rota-rod tests were performed to assess degree of colder, thermal, spontaneous motor activity and motor co-ordination changes respectively at different time intervals i.e., week 0, 4, 8 and 12. Tissue superoxide anion and total calcium levels were determined after twelve weeks to assess biochemical alterations. Histopathological evaluations of sciatic nerve were also performed to assess nerve damage. APSAE treatment increased tail flick laten...

Healing potential of Iranian traditional medicinal plants on burn wounds in alloxan-induced diabetic rats

Revista Brasileira de Farmacognosia — Sun, 05 Feb 2012 18:30:49 +0100

Malva sylvestris, Punica granatum, Amygdalus communis, Arnebia euchroma and Scrophularia deserti are important medicinal plants in Iranian traditional medicine (Unani) whose have been used as remedy against edema, burn, and wound and for their carminative, antimicrobial and anti-inflammatory activities. The ethanol extracts of M. sylvestris and P. granatum flowers, A. communis leaves, A. euchroma roots and S. deserti stems were used to evaluate the burn healing activity in alloxan-induced diabetic rats. Burns were induced in Wistar rats divided into nine groups as following; Group-I: normal rats were treated with simple ointment base (control), Group-II: diabetic rats were treated with simple ointment base (control), Groups-III and -VII: diabetic rats were treated with simple ointment base...

Immunology in clinic review series; focus on autoinflammatory diseases: inflammasomes: mechanisms of activation.

Clinical and Developmental Immunology — Sun, 05 Feb 2012 16:27:37 +0100

Authors: Mankan AK, Kubarenko A, Hornung V Abstract OTHER THEMES PUBLISHED IN THIS IMMUNOLOGY IN THE CLINIC REVIEW SERIES Allergy, Host Responses, Cancer, Type 1 diabetes and viruses, Metabolic diseases. SUMMARY: Initiation of a successful immune response requires a working set of sensors that detect any noxious agent within the cellular microenvironment and molecular platforms that process this signal to trigger an appropriate effector response. Pattern recognition receptors can engage different signalling cascades that lead to proinflammatory gene expression. At the same time, transcription-independent events such as activation of proteases and/or phagocytosis are also initiated. The inflammasome pathway constitutes a signalling platform that leads to the activation of so-called ...

Immunology in clinic review series; focus on autoinflammatory diseases: role of inflammasomes in autoinflammatory syndromes.

Clinical and Developmental Immunology — Sun, 05 Feb 2012 16:27:26 +0100

Authors: Ozkurede VU, Franchi L Abstract OTHER THEMES PUBLISHED IN THIS IMMUNOLOGY IN THE CLINIC REVIEW SERIES Allergy, Host Responses, Cancer, Type 1 diabetes and viruses, Metabolic diseases. SUMMARY: Autoinflammatory syndromes are disorders characterized by the hyperactivation of the innate immune system in the absence of microbial infection or autoantibody production. Some autoinflammatory syndromes are associated with recurrent episodes of fever and systemic inflammation that are caused by dysregulated activation of inflammasomes, molecular platforms responsible for the activation of caspase-1 and the production of interleukin (IL)-1β. In this review we will discuss the role of IL-1β and the inflammasomes in host defence and how mutations of two genes, NLRP3 and PYRIN, leads ...

Immunology in clinic review series; focus on autoinflammatory diseases: update on monogenic autoinflammatory diseases: the role of interleukin (IL)-1 and an emerging role for cytokines beyond IL-1.

Clinical and Developmental Immunology — Sun, 05 Feb 2012 16:27:15 +0100

Authors: Goldbach-Mansky R Abstract OTHER THEMES PUBLISHED IN THIS IMMUNOLOGY IN THE CLINIC REVIEW SERIES Allergy, Host Responses, Cancer, Type 1 diabetes and viruses, Metabolic diseases. SUMMARY: The disease-based discovery of the molecular basis for autoinflammatory diseases has led not only to a rapidly growing number of clinically and genetically identifiable disorders, but has unmantled key inflammatory pathways such as the potent role of the alarm cytokine interleukin (IL)-1 in human disease. Following its initial failures in the treatment of sepsis and the moderate success in the treatment of rheumatoid arthritis, IL-1 blocking therapies had a renaissance in the treatment of a number of autoinflammatory conditions, and IL-1 blocking therapies have been Food and Drug Administ...

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Understanding Patient Feedback; The Healthiest States; The Color of Diabetes

Physicians Practice — Sun, 05 Feb 2012 12:00:00 +0100

Noteworthy items from Physicians Practice (Source: Physicians Practice)

FDA Okays Another Diabetes Combo Agent

MedPage Today Public Health — Sun, 05 Feb 2012 10:13:09 +0100

WASHINGTON (MedPage Today) -- The FDA has approved an extended-release version of a combination sitagliptin and metformin for adults with type 2 diabetes. (Source: MedPage Today Public Health)

Link Between Heart Failure And Thinner Bones And Fractures

Health News from Medical News Today — Sun, 05 Feb 2012 08:00:00 +0100

Heart failure is associated with a 30 percent increase in major fractures and also identifies a high-risk population that may benefit from increased screening and treatment for osteoporosis, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM). Osteoporosis and heart failure are common, chronic and costly conditions that share common etiologic factors like older age, post-menopausal status and diabetes... (Source: Health News from Medical News Today)

Exercise In Low Oxygen Environment May Result In Improved Insulin Sensitivity

Health News from Medical News Today — Sun, 05 Feb 2012 08:00:00 +0100

Intermittent exercise with and without low oxygen concentrations (or hypoxia) can improve insulin sensitivity in type 2 diabetics, however exercise while under hypoxic conditions provides greater improvements in glycemic control than intermittent exercise alone, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM). Exercise improves glycemic control in patients with type 2 diabetes. Previous studies have focused on continuous aerobic exercise with more recent work assessing resistance exercise... (Source: Health News from Medical News Today)

Probable Mechanism Underlying Resveratrol Activity Revealed By NIH Study

Health News from Medical News Today — Sun, 05 Feb 2012 08:00:00 +0100

National Institutes of Health researchers and their colleagues have identified how resveratrol, a naturally occurring chemical found in red wine and other plant products, may confer its health benefits. The authors present evidence that resveratrol does not directly activate sirtuin 1, a protein associated with aging. Rather, the authors found that resveratrol inhibits certain types of proteins known as phosphodiesterases (PDEs), enzymes that help regulate cell energy... (Source: Health News from Medical News Today)

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Molecular Biology of Diabetes, Part II

Springer Medicine titles — Sun, 05 Feb 2012 06:01:08 +0100

Insulin Action, Effects on Gene Expression and Regulation, and Glucose TransportThese comprehensive yet concise collections of articles by world experts survey the latest findings on the molecular biology of diabetes and insulin action and synthesize a coherent understanding of the subject. Topics include the etiology of type I and type II diabetes, molecular and cellular aspects of insulin action, and the mechanism of the insulin-stimulated glucose uptake. (Source: Springer Medicine titles)

Physical activity, cardio‐respiratory fitness, and metabolic traits in rural mexican tarahumara

American Journal of Human Biology — Sun, 05 Feb 2012 05:00:00 +0100

Conclusions: This study suggests high levels of overweight and hypertension in the Tarahumara, and points to fitness and physical activity as potential intervention targets although findings should be confirmed in larger samples. Am. J. Hum. Biol. 2012. © 2012 Wiley Periodicals, Inc. (Source: American Journal of Human Biology)

FDA approves extended-release tablets for type 2 diabetes

Modern Medicine — Sun, 05 Feb 2012 05:00:00 +0100

FDA approved sitagliptin and metformin hydrochloride (HCl) extended-release (Janumet XR, Merck) tablets, a new treatment for type 2 diabetes that combines sitagliptin, which is the active component of Januvia (sitagliptin), with extended-release metformin. (Source: Modern Medicine)