MedWorm: Endocrinology

Rapid control of reproductive behaviour by locally synthesised oestrogens: focus on aromatase

Journal of Neuroendocrinology — Sat, 15 Jun 2013 19:15:05 +0100

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Lab Notes: Milk Does a Pancreas Good

MedPage Today Endocrinology — Sat, 15 Jun 2013 19:13:00 +0100

(MedPage Today) -- This week in Lab Notes, discover how milk may rejuvenate pancreatic islet cells to help manage diabetes. Plus the "dumbing" effects of anesthesia and curing well groomed mice with OCD. (Source: MedPage Today Endocrinology)

Chemical variability in the essential oils from leaves of Syzygium jambos

Revista Brasileira de Farmacognosia — Sat, 15 Jun 2013 17:19:24 +0100

Syzygium jambos (L.) Alston, Myrtaceae, occurs in tropical regions and is a widespread medicinal plant used to treat several diseases, such as hemorrhage, dysentery, diabetes, inflammation, diabetes and gastrointestinal disorders. Leaf essential oils of ten specimens of S. jambos collected from two localities of Central Brazilian Cerrado were investigated by GC-MS. Soil and foliar nutrients were analyzed to determine the mineral compositions. The aims of this study was to evaluate the influence of environmental factors on chemical composition of leaf essential oils of S. jambos. Studies on the influence of environmental factors over composition of essential oils are important because they contribute data for its cultivation, harvest and establish parameters to essential oil components. The...

Comparative effects of mature coconut water (Cocos nucifera) and glibenclamide on some biochemical parameters in alloxan induced diabetic rats

Revista Brasileira de Farmacognosia — Sat, 15 Jun 2013 17:19:24 +0100

In the present study, comparative effects of mature coconut water (Cocos nucifera L., Arecaceae) and glibenclamide in alloxan induced diabetic rats were evaluated. Diabetes mellitus was induced in Sprague-Dawly rats using alloxan monohydrate (150 mg kg-1 body weight). Treatment with lyophilized form of mature coconut water and glibenclamide in diabetic rats reduced the blood glucose and glycated hemoglobin along with improvement in plasma insulin level. Elevated levels of liver function enzymes markers like alkaline phosphatase, serum glutamate oxaloacetate transaminase and serum glutamate pyruvate transaminase in diabetic rats were significantly reduced on treatment with mature coconut water. In addition to this, diabetic rats showed altered levels of blood urea, serum creatinine, albumin...

Topical anti-inflammatory activity of yacon leaf extracts

Revista Brasileira de Farmacognosia — Sat, 15 Jun 2013 17:19:24 +0100

In conclusion, yacon leaf extracts, particularly the sesquiterpene lactone-rich extract, has potential use as topical anti-inflammatory agent. (Source: Revista Brasileira de Farmacognosia)

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Molecular signaling cascade of miRNAs in causing Diabetes Nephropathy.

Bioinformation — Sat, 15 Jun 2013 14:35:03 +0100

Authors: Padmashree DG, Swamy NR Abstract Diabetic nephropathy (DN) is one of the major microvascular diseases and most common in diabetic patient, finally results in kidney failure. The main features of DN are basement membrane thickening, microalbuminuria, proteinuria, glomerular, mesangial hypertrophy and ECM protein accumulation. Recent discoveries have been shown that numerous pathways are activated during the development of DN in Diabetes mellitus. The small non-coding miRNA plays an important role in regulating the pathway which is involved in DN. In our study we consolidate different pathways which regulated by miRNAs in molecular signaling which results in causing DN. We embedded entire pathway in the form of regulatory network and we could able to understand that some of ...

InDiaMed: A Comprehensive Database of Indian Medicinal plants for Diabetes.

Bioinformation — Sat, 15 Jun 2013 14:35:03 +0100

Authors: Tota K, Rayabarapu N, Moosa S, Talla V, Bhyravbhatla B, Rao S Abstract UNLABELLED: According to International Diabetes Federation (IDF), India has 62.4 million people with diabetes and by 2030 it is predicted that the number will rise to 100 million. Studies claim that there are around 410 experimentally proven Indian medicinal plants which have anti-diabetic activity, of which the mechanism of action of 109 plants has been elucidated or reported. So, the need of the hour is to explore the claims of Indian medicinal flora and open up the facets of many Indian plants which are being examined for their beneficial role in diabetes. So, we created a database (InDiaMed) of Indian medicinal plants that captures their role in anti-diabetic activity. InDiaMed's features include ch...

Phyto diab care: Phytoremedial database for antidiabetics.

Bioinformation — Sat, 15 Jun 2013 14:35:03 +0100

Authors: Luhach S, Goel A, Taj G, Goyal P, Kumar A Abstract UNLABELLED: Diabetes, a chronic disease debilitating to normal healthy lifestyle, onsets due to insufficient amount of insulin production or ineffective utilization of the amount produced. Although, pharmaceutical research has brought up remedial drugs and numerous candidates in various phases of clinical trials, off-target effects and unwanted physiological actions are a constant source of concern and contra indicatory in case of diabetic patients. Here we present a phytoremedial database, Phyto Diab Care, broadly applicable to any known anti-diabetic medicinal plant and phytochemicals sourced from them. Utilization of the traditional medicine knowledge for combating diabetes without creating unwanted physiological action...

Recent Trends in the Incidence, Geographical Distribution, and Survival From Thyroid Cancer in Wales, 1985–2010

Thyroid — Sat, 15 Jun 2013 03:03:32 +0100

Thyroid , Vol. 0, No. 0. (Source: Thyroid)

Incretin Talk Continues at ENDO Meeting

MedPage Today Cardiovascular — Fri, 14 Jun 2013 19:13:00 +0100

SAN FRANCISCO (MedPage Today) -- As the debate over pancreatic risks with incretin therapies for type 2 diabetes comes to a boil, it's likely to be the topic of much discussion at this year's meeting of the Endocrine Society. (Source: MedPage Today Cardiovascular)

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Pancreatic Cancer and Incretins: No Signal as Yet at NIDDKPancreatic Cancer and Incretins: No Signal as Yet at NIDDK

Medscape Today Headlines — Fri, 14 Jun 2013 14:48:01 +0100

A definitive answer on whether there is an increased risk of pancreatic cancer with incretin diabetes drugs is still some years away, said dozens of experts at the NIDDK this week. Medscape Medical News (Source: Medscape Today Headlines)

Diabetes mellitus, hypertension and albuminuria in rural Zambia: a hospital‐based survey

Tropical Medicine and International Health — Fri, 14 Jun 2013 14:15:04 +0100

ConclusionThis hospital‐based survey in rural Zambia found a lower frequency of albuminuria among the participants than in previous studies of patients with DM or HTN in urban sub‐Saharan Africa. (Source: Tropical Medicine and International Health)

Quick Postmeal Walks Better Than Once-Daily Longer OnesQuick Postmeal Walks Better Than Once-Daily Longer Ones

Medscape Today Headlines — Fri, 14 Jun 2013 13:20:41 +0100

In older adults with impaired fasting glucose, only postmeal exercise reduced after-dinner glycemia. Medscape Medical News (Source: Medscape Today Headlines)

Longer Acting GLP-1 Agonists and Improved CV OutcomesLonger Acting GLP-1 Agonists and Improved CV Outcomes

Medscape Today Headlines — Fri, 14 Jun 2013 13:05:20 +0100

Not only do GLP-1 receptor agonists reduce weight and A1c levels, but they also may improve cardiac parameters. Expert Review of Endocrinology and Metabolism (Source: Medscape Today Headlines)

Dad's life stress exposure can affect offspring brain development, Penn Study finds (EurekAlert, 12 June 2013)

Society for Endocrinology — Fri, 14 Jun 2013 12:00:00 +0100

A US study published in Journal of Neuroscience compares the stress response in the offspring of male mice exposed to stress at the preadolescent and adult stages, and investigates potential mechanisms taking place at fertilisation. Full article (Source: Society for Endocrinology)

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Men 'to blame for the menopause' (BBC News Online, 14 June 2013)

Society for Endocrinology — Fri, 14 Jun 2013 12:00:00 +0100

A paper in PLOS Computational Biology uses a computational model of deleterious mutation accumulation to propose a mechanism for the development of menopause could be caused by male mating preference. Full article (Source: Society for Endocrinology)

PhD Studentship in Breast Cancer Biology, Dublin, Eire

Society for Endocrinology — Fri, 14 Jun 2013 12:00:00 +0100

Added via Naturejobs. A SFI funded PhD position is available within the Dept of Surgery, Royal College of Surgeons in Ireland. The Endocrine Oncology Research Group (EORG) within the Dept of Surgery focus on the molecular mechanisms underlying endocrine resistance in breast cancer. This project will investigate whether the steroid coactivator protein SRC-1 mediates reprogramming in individual cells to induce survival adaptability and drug resistance in human breast cancer. The successful candidate will be a highly motivated student with an upper second or first class honours degree in Biochemistry, Genetics or related subject. The research is multidisciplinary using a combination of standard molecular biology techniques, in vivo mouse models and clinical samples. The d...

'Intersex' included on Australia's new gender guidelines (AFP, 14 June 2013)

Society for Endocrinology — Fri, 14 Jun 2013 12:00:00 +0100

The Australian government has introduced new guidelines which recommend that personal records held by federal government departments and agencies should provide the option of selecting "male", "female" or "intersex". Full article (Source: Society for Endocrinology)

Long-term clinical follow-up of the multicentre, randomized study to test immunosuppressive therapy with oral prednisone for the prevention of restenosis after percutaneous coronary interventions: Cortisone plus BMS or DES veRsus BMS alone to EliminAte Restenosis (CEREA-DES)

European Heart Journal — Fri, 14 Jun 2013 04:00:00 +0100

Conclusions The clinical benefits of prednisone compared with BMS only persisted almost unchanged at 4 years. Drug-eluting stents performed better than BMS at long-term, although the advantages observed at 1 year were in part attenuated because of the occurrence of very late stent thrombosis and late revascularizations. Clinical Trial NCT 00369356. (Source: European Heart Journal)

Comparative effect of clopidogrel and aspirin versus aspirin alone on laboratory parameters: a retrospective, observational, cohort study

Cardiovascular Diabetology — Fri, 14 Jun 2013 04:00:00 +0100

Conclusion: Our findings suggested that hematological adverse effects may be greater with combination therapy of clopidogrel plus aspirin than with aspirin monotherapy. (Source: Cardiovascular Diabetology)

Chronic treatment with taurine ameliorates diabetes‐induced dysfunction of nitric oxide‐mediated neurogenic and endothelium‐dependent corpus cavernosum relaxation in rats

Fundamental and Clinical Pharmacology — Fri, 14 Jun 2013 04:00:00 +0100

This study was aimed to examine the effect of chronic taurine treatment on corpus cavernosum dysfunction in diabetic rats and to investigate possible underlying mechanisms.Thirty male rats were randomized to three groups of ten each, including control, diabetic, and taurine‐treated diabetic. Diabetes was induced in rats by streptozotosin (STZ, single intraperitoneal dose of 50 mg/kg body weight). Taurine was administered orally for 12 weeks (1% w/v in drinking water) from the day on which STZ was injected. At the end ofthe 12th week, strips of corpus cavernosum were suspended in an organ bath system for functional studies. Nitric oxide (NO)‐mediated endothelium‐dependent and neurogenic corpus cavernosum relaxation were evaluated by acetylcholine (ACh, 0.1 nM‐100 μM) and electrical...

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Neurosteroids And Epileptogenesis

Journal of Neuroendocrinology — Fri, 14 Jun 2013 04:00:00 +0100

Prenatal corticosteroids modify glutamatergic and GABAergic synapse genomic fabric: Insights from a novel animal model of infantile spasms

Journal of Neuroendocrinology — Fri, 14 Jun 2013 04:00:00 +0100

Non‐Classical Progesterone Signalling Molecules in the Nervous System

Journal of Neuroendocrinology — Fri, 14 Jun 2013 04:00:00 +0100

Stroke neuroprotection: Estrogen and IGF‐1 interactions and the role of microglia

Journal of Neuroendocrinology — Fri, 14 Jun 2013 04:00:00 +0100

Developmental Hypothyroxinemia Induced by Maternal Mild Iodine Deficiency Delays Hippocampal Axonal Growth in the Rat Offspring

Journal of Neuroendocrinology — Fri, 14 Jun 2013 04:00:00 +0100

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Reduction of the number of neurons in the caudal mesenteric ganglion innervating the ovary in sexually mature gilts following testosterone administration

Journal of Neuroendocrinology — Fri, 14 Jun 2013 04:00:00 +0100

Being suckled in a large litter mitigates the effects of early life stress on HPA axis function in the rat

Journal of Neuroendocrinology — Fri, 14 Jun 2013 04:00:00 +0100

Glucagon‐Like Peptide‐1 Receptor in the Brain: Role in Neuroendocrine Control of Energy Metabolism and Treatment Target for Obesity

Journal of Neuroendocrinology — Fri, 14 Jun 2013 04:00:00 +0100

The central glucagon‐like peptide (GLP)‐1 receptor mediates a number of metabolic processes, including feeding, body weight and glucose homeostasis. More recently, roles in energy expenditure and reward pathway modulation have been described. GLP‐1 receptor agonism promotes insulin release and is currently used to treat type 2 diabetes humans, with a common side effect being weight loss. It is likely that many of these metabolic effects are mediated by GLP‐1Rs located in the central nervous system, throughout areas known to be important in control of energy homeostasis. The physiological role of the GLP‐1 receptor signalling in each of these brain nuclei is becoming clearer and the GLP‐1 system appears to act as an integrator of peripheral energy availability and effector of me...

Low‐Dose Dexamethasone Treatment Promotes the Pro‐Survival Signalling Pathway in the Adult Rat Prefrontal Cortex

Journal of Neuroendocrinology — Fri, 14 Jun 2013 04:00:00 +0100

Synthetic glucocorticoid dexamethasone (DEX), a highly potent anti‐inflammatory and immunosuppressive agent, is widely used in the treatment of brain cancer, as well as for inflammatory and autoimmune diseases. The present study aimed to determine whether low‐dose subchronic DEX treatment (100 μg/kg for eight consecutive days) exerts long‐term effects on apoptosis in the adult rat prefrontal cortex (PFC) by examining the expression of cell death‐promoting molecules [poly(ADP‐ribose) polymerase (PARP), p53, procaspase 3, cleaved caspase 3, Bax] and cell‐survival molecules (AKT, Bcl‐2). The results obtained revealed that body, thymus and adrenal gland weights, as well corticosterone levels, in the serum and PFC were reduced 1 day after the last DEX injection. In the PFC, DEX...

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Delta‐like 1 Homologue is a Hypothalamus‐Enriched Protein that is Present in Orexin‐Containing Neurones of the Lateral Hypothalamic Area

Journal of Neuroendocrinology — Fri, 14 Jun 2013 04:00:00 +0100

Delta‐like 1 homologue (DLK1), also known as preadipocyte factor‐1, fetal antigen 1 or pG2, is a transmembrane protein belonging to the epidermal growth factor‐like superfamily. The protein becomes soluble and biologically active after cleavage of the tumour necrosis factor‐α‐converting enzyme. DLK1 is involved in the differentiation of several cell types, including adipocytes. Lack of the dlk1 gene in mice results in adiposity and a polymorphism within the gene encoding DLK1 has been associated with obesity. The dlk1 gene is expressed in restricted areas of the central nervous system with an enrichment of cell bodies expressing DLK1 mRNA in the hypothalamus. Goat and rabbit antisera to DLK1 were used to study the cellular localisation and chemical identity of DLK1‐immunoreact...

Growth Factor Receptor‐Bound Protein 10‐Mediated Negative Regulation of the Insulin‐Like Growth Factor‐1 Receptor‐Activated Signalling Pathway Results in Cognitive Disorder in Diabetic Rats

Journal of Neuroendocrinology — Fri, 14 Jun 2013 04:00:00 +0100

Growth factor receptor‐bound protein 10 (Grb10) is a Src homology 2 domain‐containing protein and one of the binding partners for several transmembrane tyrosine kinase receptors, including insulin receptor (IR) and insulin‐like growth factor‐1 receptor (IGF1‐R). The hippocampus, which is critical for cognitive functions, is one of the main distribution areas of Grb10 in the central nervous system. In recent years, diabetic encephalopathy has been defined as a third type of diabetes and the IGF1‐IR pathway was shown to be critical for the neuropathogenic process of cognitive disorder in diabetes. However, the role of endogenous Grb10 in regulating the IGF1‐IR pathway and neurobehavioural changes is not explicit. The present study aimed to determine the in vivo function of endo...

Minor Changes in Gene Expression in the Mouse Preoptic Hypothalamic Region by Inflammation‐Induced Prostaglandin E2

Journal of Neuroendocrinology — Fri, 14 Jun 2013 04:00:00 +0100

We investigated to what extent inflammation‐induced prostaglandin E2 (PGE2) regulates gene expression in the central nervous system. Wild‐type mice and mice with deletion of the gene encoding microsomal prostaglandin E synthase‐1 (mPGES‐1), which cannot produce inflammation‐induced PGE2, were subjected to peripheral injection of bacterial wall lipopolysaccharide (LPS) and killed after 5 h. The median and medial preoptic nuclei, which are rich in prostaglandin E receptors, were isolated by laser capture microdissection (LCM), and subjected to whole genome microarray analysis. Although the immune stimulus induced robust transcriptional changes in the brain, as seen by a quantitative reverse transcriptase‐polymerase chain reaction (qRT‐PCR) on selected genes, only small PGE2‐...

Intranasal Application of Vasopressin Fails to Elicit Changes in Brain Immediate Early Gene Expression, Neural Activity and Behavioural Performance of Rats

Journal of Neuroendocrinology — Fri, 14 Jun 2013 04:00:00 +0100

Intranasal administration has been widely used to investigate the effects of the neuropeptides vasopressin and oxytocin on human behaviour and neurological disorders, although exactly what happens when these neuropeptides are administered intranasally is far from clear. In particular, it is not clear whether a physiological significant amount of peptide enters the brain to account for the observed effects. In the present study, we investigated whether the intranasal administration of vasopressin and oxytocin to rats induces the expression of the immediate‐early gene product Fos in brain areas that are sensitive to centrally‐administered peptide, whether it alters neuronal activity in the way that centrally‐administered peptide does, and whether it affects behaviour in the ways that a...

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Plasma Oxytocin and Vasopressin do not Predict Neuropeptide Concentrations in Human Cerebrospinal Fluid

Journal of Neuroendocrinology — Fri, 14 Jun 2013 04:00:00 +0100

The involvement of the neuropeptides oxytocin (OXT) and vasopressin (AVP) in human socio‐emotional behaviours is attracting increasing attention. There is ample evidence for elevated plasma levels upon a wide variety of social and emotional stimuli and scenarios, ranging from romantic love via marital distress up to psychopathology, with cause versus consequence being largely unclear. The present study examined whether plasma levels of both OXT and AVP are reflective of central neuropeptide levels, as assumed to impact upon socio‐emotional behaviours. Concomitant plasma and cerebrospinal fluid (CSF) samples were taken from 41 non‐neurological and nonpsychiatric patients under basal conditions. Although OXT and AVP levels in the CSF exceeded those in plasma, there was no correlation b...

Navigating Pituitary Structure and Function ‐ Defining a Roadmap for Hormone Secretion

Journal of Neuroendocrinology — Fri, 14 Jun 2013 04:00:00 +0100

Summary The human pituitary gland may be the size of a pea, but it punches well above its weight due to secretion of hormones that regulate essential homeostatic processes ranging from growth to stress. Recent advances in imaging and genetics have allowed large‐scale interrogation of pituitary structure and function, and in doing so, have revealed that output relies on its organisation into highly plastic networks. (Source: Journal of Neuroendocrinology)

Treat‐to‐target trials: uses, interpretation and review of concepts

Diabetes, Obesity and Metabolism — Fri, 14 Jun 2013 04:00:00 +0100

Treat‐to‐target trial designs compare investigational insulins with a standard insulin. Treat‐to‐target trials force‐titrate insulin dosages to achieve a prespecified treatment goal. With comparable glycaemic control, comparisons of safety endpoints such as hypoglycaemia can be made to establish the risk‐benefit profile of the new insulin. Glargine versus NPH showed comparable A1C reductions; however, A1C <7% without associated nocturnal hypoglycaemia was reached in more patients on glargine and overall hypoglycaemia was lower. Detemir versus glargine showed non‐inferiority between the groups; however, with less weight gain and more injection site reactions with detemir. Detemir/aspart versus glargine/aspart showed non‐inferiority between the treatments, however, with le...

Heart failure in hospitalized patients with diabetic foot ulcers: Clinical characteristics and their relationship with prognosis

Journal of Diabetes — Fri, 14 Jun 2013 04:00:00 +0100

ConclusionsThe prevalence of HF is high in Chinese inpatients with DFU, with the presence of HF indicating a worse prognosis for these patients. (Source: Journal of Diabetes)

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The effect of physical activity on the mental and physical health of childhood cancer survivors.

British Journal of Sports Medicine — Fri, 14 Jun 2013 01:40:14 +0100

CONCLUSIONS: Exercise training improves aerobic fitness in childhood cancer survivors, yet the small sample size did not allow identification of additional expected benefits. Nevertheless, changes in fitness over 6 months were significantly correlated with measures of body composition, bone health and quality of life. Childhood cancer survivors should be continuously encouraged to exercise, in order to both improve their immediate well-being, and to decrease their risks for potential late effects of pediatric cancer. The study was funded by the Israel Cancer Association. PMID: 23757651 [PubMed - in process] (Source: British Journal of Sports Medicine)

Efficacy of acute high-intensity interval training in lowering glycemia in patients with type 2 diabetes: diabetes em movimento(r) pilot study.

British Journal of Sports Medicine — Fri, 14 Jun 2013 01:40:14 +0100

CONCLUSIONS: HIIT appears to be an effective and safe exercise strategy to acutely control blood glucose in patients with type 2 diabetes. TRIAL FUNDING AND REGISTRATION: Diabetes em Movimento® is funded by Portuguese Foundation for Science and Technology with reference SFRH/BD/47733/2008 and is registered in Current Controlled Trials with reference ISRCTN09240628. PMID: 23757644 [PubMed - in process] (Source: British Journal of Sports Medicine)

Diabetes em movimento(r) - community-based exercise program for patients with type 2 diabetes.

British Journal of Sports Medicine — Fri, 14 Jun 2013 01:40:11 +0100

CONCLUSIONS: This exercise program has a high applicability and involves minimal material resources and can be easily replicated in a community context. Type 2 diabetic patients can practice exercise safely with this type of supervised exercise programs. TRIAL FUNDING AND REGISTRATION: Diabetes em Movimento® is funded by Portuguese Foundation for Science and Technology with reference SFRH/BD/47733/2008 and is registered in Current Controlled Trials with reference ISRCTN09240628. PMID: 23757674 [PubMed - in process] (Source: British Journal of Sports Medicine)

Exuberant inflammatory reaction after an infiltration of platelet-rich plasma (prp).

British Journal of Sports Medicine — Fri, 14 Jun 2013 01:40:04 +0100

CONCLUSIONS: This case report calls attention to potential side effects that are linked to this new therapy by infiltration of platelet rich plasma in case of tendinopathy, in particular when used in patients with type 1 diabetes. Thus, the balance between benefits and risks must be carefully evaluated before using this treatment in patients with type 1 diabetes. PMID: 23757720 [PubMed - in process] (Source: British Journal of Sports Medicine)

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ADA Wants Firms to Disclose Incretin Data

MedPage Today Cardiovascular — Thu, 13 Jun 2013 22:13:00 +0100

(MedPage Today) -- The American Diabetes Association is calling for makers of incretin therapies to release all of their data on the drugs in an effort to clarify whether they have adverse effects on the pancreas, the group said. (Source: MedPage Today Cardiovascular)

Women are at a higher risk of metabolic syndrome in rural malaysia.

Women and Health — Thu, 13 Jun 2013 20:45:02 +0100

The objective of this study was to determine gender differences in the prevalence and factors associated with metabolic syndrome in a rural Malay population. This cross-sectional study, conducted in Bachok, Kelantan, involved 306 respondents aged 18 to 70 years. The survey used a structured questionnaire to collect information on demographics, lifestyle, and medical history. Anthropometric measurements, such as weight, height, body mass index, waist and hip circumference, and blood pressure were measured. Venous blood samples were taken by a doctor or nurses and analyzed for lipid profile and fasting glucose. The overall prevalence of metabolic syndrome was 37.5% and was higher among females (42.9%). Being unemployed or a housewife and being of older age were independently associated with ...

'Something for Everyone' on the Menu at ADA'Something for Everyone' on the Menu at ADA

Medscape Today Headlines — Thu, 13 Jun 2013 17:08:17 +0100

A plethora of presentations at the ADA Scientific Sessions this year should ensure that everyone involved in diabetes research and treatment will find something to whet their appetite. Medscape Medical News (Source: Medscape Today Headlines)

The New Old Age: Price Reductions for Diabetes Care Supplies

NYT Health — Thu, 13 Jun 2013 16:55:49 +0100

Medicare is reducing fees for diabetes care supplies, and beneficiaries are likely to be charged less, too. (Source: NYT Health)

Soda Ban Would Target Heavy Youth, Not Poor: StudySoda Ban Would Target Heavy Youth, Not Poor: Study

Medscape Medical News Headlines — Thu, 13 Jun 2013 16:22:24 +0100

A cap on soda size - such as the one New York City regulators are trying to pass - would have the biggest impact on overweight kids and young adults, a new study suggests. Reuters Health Information (Source: Medscape Medical News Headlines)

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At-Home Weight Loss Programs for Kids Lack EvidenceAt-Home Weight Loss Programs for Kids Lack Evidence

Medscape Medical News Headlines — Thu, 13 Jun 2013 16:22:24 +0100

Programs designed to prevent childhood obesity in the home don't affect kids' weight a year or more down the line, according to a review of the evidence. Reuters Health Information (Source: Medscape Medical News Headlines)

Guidelines Key to Gestational Diabetes Dx (CME/CE)

MedPage Today Cardiovascular — Thu, 13 Jun 2013 16:13:00 +0100

(MedPage Today) -- Differences in screening criteria for gestational diabetes are associated with large variations in the proportion of patients diagnosed with the condition, researchers found. (Source: MedPage Today Cardiovascular)

American Diabetes Association (ADA) 73rd Scientific Sessions®American Diabetes Association (ADA) 73rd Scientific Sessions®

Medscape Today Headlines — Thu, 13 Jun 2013 14:27:51 +0100

Read clinically focused news coverage of key developments from ADA 2013. Medscape Diabetes & Endocrinology (Source: Medscape Today Headlines)

Computed Tomography Diagnosis of Active Bleeding into the Thyroid Gland

Thyroid — Thu, 13 Jun 2013 13:50:51 +0100

Thyroid , Vol. 0, No. 0. (Source: Thyroid)

Is There an Optimal Diet for Patients With Type 2 Diabetes?Is There an Optimal Diet for Patients With Type 2 Diabetes?

Medscape Today Headlines — Thu, 13 Jun 2013 13:05:23 +0100

Which diet is best for patients with type 2 diabetes? High protein, very low carbohydrate, or Mediterranean? The British Journal of Diabetes and Vascular Disease (Source: Medscape Today Headlines)

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Cholesterol Metabolism After Bariatric Surgery in ObesityCholesterol Metabolism After Bariatric Surgery in Obesity

Medscape Today Headlines — Thu, 13 Jun 2013 13:05:22 +0100

Does gastric bypass surgery decrease cholesterol levels more than gastric banding? Diabetes Care (Source: Medscape Today Headlines)

Recognising low blood sugars could help prevent brain damage in newborn babies (AlphaGalileo, 12 June 2013)

Society for Endocrinology — Thu, 13 Jun 2013 12:00:00 +0100

A UK study published in Frontiers in Endocrinology assesses neurodevelopmental outcomes amongst newborn children presenting with transient or short-term congenital hyperinsulinism. Full article (Source: Society for Endocrinology)

Study: Bisphenol A gets directly through the mouth into the bloodstream (AFP, 13 June 2013)

Society for Endocrinology — Thu, 13 Jun 2013 12:00:00 +0100

A study from France published in Environmental Health Perspectives compares the bioavailability of bisphenol A administered sublingually and orally in dogs. Full article (in German) (Source: Society for Endocrinology)

MEP calls for parliamentary risk panel to tame green ‘scaremongering’ (Euractiv, 12 June 2013)

Society for Endocrinology — Thu, 13 Jun 2013 12:00:00 +0100

A UK MEP speaking at the European Risk Summit in Dublin, Republic of Ireland, has argued for the formation of a 'formal risk group' within the European Parliament as an advisory panel to lawmakers on contentious issues involving potential risks to human health. Full article (Source: Society for Endocrinology)

British Thyroid Foundation Awards

Society for Endocrinology — Thu, 13 Jun 2013 12:00:00 +0100

The British Thyroid Foundation invites applications each year to its two funding streams, the Evelyn Ashley Smith Awards for Nurses and the Research Award. The two Nurse awards consist of up to £500 to help cover conference/training expenses, including registration fees and /or travel costs, and/or (you may apply to both) £1000 to help support a specific project lasting one year; support an on-going project; or reward a piece of work already completed, but not yet published. The deadline for these awards is 1 July 2013. The Research Award consists of up to £20,000 to support medical research projects directed to the study of thyroid disorders or investigations into the basic understanding of thyroid function. Studies funded through this fun...

Efficacy and Mechanism Evaluation grant: sarcopaenia and its effects on older people

Society for Endocrinology — Thu, 13 Jun 2013 12:00:00 +0100

Applications are sought for research into interventions used in the prevention, diagnosis, management, monitoring or treatment of older people experiencing the effects of sarcopaenia, particularly where sarcopaenia is affecting their health, leading to dependency or impairing recovery from accident, illness or surgery. This commissioned research call is made by the MRC and NIHR Efficacy and Mechanism Evaluation Programme, which aims to bridge preclinical studies and evidence of clinical efficacy. The value of the grant is expected to be in the region of £0.5-2 million. The deadline for applictions is 1 October 2013. More information is available via the link below. http://www.eme.ac.uk/funding/Commissioning.asp (Source: Society for Endocrinology)

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NIHR career development competitions

Society for Endocrinology — Thu, 13 Jun 2013 12:00:00 +0100

The National Institute for Health Research (NIHR) has the following competitions open to provide researchers at all stages of their careers with development opportunities in academic medicine: NIHR Clinician Scientist: up to 5 years funding to undertake focussed training and development in order to develop specific skills that will enable a transition from basic research into clinical research or from clinical research into translational and applied research. Deadline: 10 July 2013. NIHR Senior Investigator: Senior Investigators are fundamental to the NIHR Faculty and include some of the country’s foremost researchers, making the most outstanding contribution to clinical and applied health and social care research. Leading researchers funded by the NIHR or the Departme...

Ovarian Cancer Action research grants

Society for Endocrinology — Thu, 13 Jun 2013 12:00:00 +0100

Ovarian Cancer Action, the UK’s leading ovarian cancer charity, has opened a call for new and innovative research grant applications, with the view to starting new and exciting projects in early 2014. A fund of £600,000 over three years has been identified for innovative research that will provide critical pilot data or new insights into the current major scientific challenges in ovarian cancer. Preliminary applications must be submitted by 11:59 on 29 August 2013. For more information please visit the Ovarian Cancer Action website. (Source: Society for Endocrinology)

MRC Experimental Medicine Challenge Grants

Society for Endocrinology — Thu, 13 Jun 2013 12:00:00 +0100

The Medical Research Council (MRC) invites applications for its Experimental Medicine Challenge Grants, which support ambitious, challenge-led programmes of research into disease pathophysiology in humans. These studies will produce major new mechanistic insights into human disease, with potential application to new therapeutic approaches and opportunities for “reverse translation” to more basic research. In addition to the conventional Experimental Medicine Challenge Grants, applications for smaller “Pathfinder” awards are welcomed. The deadline for outline applications is 25 July 2013. For more information please visit the MRC website. (Source: Society for Endocrinology)

Breast Cancer Campaign pilot grants

Society for Endocrinology — Thu, 13 Jun 2013 12:00:00 +0100

Breast Cancer Campaign invites applications to its pilot grants, to test new hypotheses and generate preliminary data to support a full project grant application. Grants of up to £20,000 are available for up to one year. The deadline for applications is 2 September 2013. For more information on the grants please visit the Breast Cancer Campaign website. (Source: Society for Endocrinology)

Professor, Reader, Senior Lecturer or Lecturer positions in Diabetes, Endocrinology and Metabolism - Imperial College London, UK

Society for Endocrinology — Thu, 13 Jun 2013 12:00:00 +0100

Added via www.naturejobs.com. Imperial College London is making a substantial new investment in Diabetes, Endocrinology and Metabolism. They plan to make senior academic appointments to build upon existing strengths and develop a world-leading translational research programme in collaboration with Imperial College Healthcare NHS Trust. There are major research programmes in gut hormones and obesity, genetics of obesity and diabetes, the pathogenesis of diabetes, mechanisms of thyroid hormone action, and bone and mineral metabolism. They are seeking clinical or non-clinical academics with highly innovative research objectives and a track record of high quality publications. The level of appointment (Professor, Reader, Senior Lecturer or Lecturer) and the generous supporting package will be...

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Postdoctoral Research Associates, Institute of Metabolic Science (2/3 posts), University of Cambridge, UK

Society for Endocrinology — Thu, 13 Jun 2013 12:00:00 +0100

Added via NatureJobs. Applications are invited to join the dynamic, internationally recognised team led by Professor Toni Vidal-Puig studying 1) mechanisms of adipose tissue expandability, 2) mechanisms of adipose tissue macrophage polarisation and 3) central and peripheral mechanisms of brown fat activation and thermogenesis (supported by BBSRC and EC FP7 BetaBAT consortium). The successful candidate will hold a PhD in a relevant biological sciences discipline with experience in at least one of the three proposed research areas supported by a proven track record reflected in a strong record of publication. Ideally he/she will have a strong background in in vivo physiology and cellular and molecular biology. Experience in bioinformatics and lipid chemistry is a significant advantage. Cand...

Academic Positions in Veterinary Sciences and Medicine, University of Surrey, UK

Society for Endocrinology — Thu, 13 Jun 2013 12:00:00 +0100

The University of Surrey is currently looking for individuals at Lecturer/Senior Lecturer/Tutor/Senior Tutor levels in a variety of areas, including endocrine systems, to join its new School of Veterinary Medicine which opens in September 2014. The closing date for applications is 12 August 2013. For more information on eligibility criteria for positions at each grade, and to apply, please visit the job advert. (Source: Society for Endocrinology)

NIHR Clinical Lecturer in Intensive Care Medicine, University of Birmingham, UK

Society for Endocrinology — Thu, 13 Jun 2013 12:00:00 +0100

Added via www.jobs.ac.uk. Applications are invited for the post of NIHR Clinical Lecturer in Intensive Care Medicine (ICM) in the School of Clinical and Experimental Medicine at the University of Birmingham. The main aim of this post is to nurture the academic development of a post-doctoral trainee in ICM, enabling the individual to develop into an independent principal investigator capable of securing a Clinician Scientist Fellowship in the future. The appointee will be expected to contribute significantly to the established research and education programmes of the School, linking the growing speciality of ICM to clinical or health services research; infection, inflammation and immunomodulation; endocrine dysfunction; and trauma and regeneration. Applicants should have completed...

Recognising Low Blood Sugars Could Help Prevent Brain Damage In Newborn Babies

Health News from Medical News Today — Thu, 13 Jun 2013 09:00:00 +0100

Researchers from The University of Manchester studying a rare and potentially lethal childhood disease - which is the clinical opposite of diabetes - have made an important discovery. The team has found newborn babies with transient (also known as short-term) congenital hyperinsulinism (CHI) are at risk of developing, long-term disability or brain damage due to low blood sugars. Previously it was thought only babies with the most severe form, known as persistent CHI, were at risk of brain damage... (Source: Health News from Medical News Today)

TEDDY Study Yielding New Approach To Finding High-Risk Genes For Type 1 Diabetes

Health News from Medical News Today — Thu, 13 Jun 2013 09:00:00 +0100

Massive samples emanating from a decade-old, international initiative to determine how genetics and environment cause type 1 diabetes are giving scientists a unique perspective on which molecular and environmental factors really contribute to the disease. The TEDDY study, following nearly 9,000 at-risk children from birth to age 15, is enabling scientists to parse which genetic mutations correlate with progression or lack of progression to type 1 diabetes, said Dr... (Source: Health News from Medical News Today)

Study Suggests Association Between Hypoglycemia, Dementia In Older Adults With Diabetes

Health News from Medical News Today — Thu, 13 Jun 2013 09:00:00 +0100

A study of older adults with diabetes mellitus (DM) suggests a bidirectional association between hypoglycemic (low blood glucose) events and dementia, according to a report published Online First by JAMA Internal Medicine, a JAMA Network publication. There is a growing body of evidence that DM may increase the risk for developing cognitive impairment, including Alzheimer disease and vascular dementia, and there is research interest in whether DM treatment can prevent cognitive decline... (Source: Health News from Medical News Today)

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Overeating And Weight Gain Contributing To Onset Of Diabetes Could Be Related To A Deficit In Reward Circuits In The Brain

Health News from Medical News Today — Thu, 13 Jun 2013 08:00:00 +0100

Using positron emission tomography (PET) imaging of the brain, researchers have identified a sweet spot that operates in a disorderly way when simple sugars are introduced to people with insulin resistance, a precursor to type 2 diabetes. For those who have the metabolic syndrome, a sugar drink resulted in a lower-than-normal release of the chemical dopamine in a major pleasure center of the brain. This chemical response may be indicative of a deficient reward system, which could potentially be setting the stage for insulin resistance... (Source: Health News from Medical News Today)

Studies Demonstrate The Strategy To Kill Melanoma Using Diabetes Drugs To Sensitize Resistant Cells

Health News from Medical News Today — Thu, 13 Jun 2013 08:00:00 +0100

Advanced metastatic melanoma is a disease that has proven difficult to eradicate. Despite the success of melanoma-targeting drugs, tumors inevitably become drug resistant and return, more aggressive than before. In the current issue of the journal Cancer Cell, however, researchers at The Wistar Institute describe how they increase the effectiveness of anti-melanoma drugs by combining anticancer therapies with diabetes drugs. (Article link*... (Source: Health News from Medical News Today)

Obesity During Pregnancy Programs Offspring To Be Fat, But Legacy Can Be Overturned

Health News from Medical News Today — Thu, 13 Jun 2013 07:00:00 +0100

Scientists in Sydney, Australia, have discovered that obesity and type 2 diabetes in pregnancy can program children to develop metabolic problems later in life. The good news is, this legacy is not set in stone - if children of obese mothers are careful about what they eat, it can be overturned. The study, carried out by scientists at the Victor Chang Cardiac Research Institute, is published in the June edition of the journal Epigenetics. By using genetically identical mice as a model, the team investigated the effects of having a mother with obesity and type 2 diabetes... (Source: Health News from Medical News Today)

Identifying Diabetic Foot Infection And Ruling Out A Non-Infectious Complication That Develops In Nerve-Damaged Joints

Health News from Medical News Today — Thu, 13 Jun 2013 07:00:00 +0100

Researchers are kick-starting better diabetic foot care and promoting reduced radiation dose with a new take on a hybrid molecular imaging technique. By targeting both bone cell activity and immune response and improving imaging data interpretation, doctors can better distinguish diabetic foot infection from another common foot condition that often requires an additional bone-marrow scan for definitive diagnosis, say researchers presenting a study at the Society of Nuclear Medicine and Molecular Imaging's 2013 Annual Meeting... (Source: Health News from Medical News Today)

Inadequate Noncommunicable Disease Prevention In Low-And Middle-Income Countries

Health News from Medical News Today — Thu, 13 Jun 2013 07:00:00 +0100

Nine years after the World Health Organization adopted a global strategy on diet, physical activity, and health to address risk factors for chronic diseases such as heart disease and diabetes (referred to internationally as noncommunicable diseases), only a few low-and middle-income countries have implemented robust national policies to help prevent such diseases, according to a study by international researchers published in this week's PLOS Medicine... (Source: Health News from Medical News Today)

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Workers In India Who Walk Or Cycle To Their Job Likely To Be A Healthier Weight

Health News from Medical News Today — Thu, 13 Jun 2013 07:00:00 +0100

People in India who walk or cycle to work are less likely to be overweight or obese, according to a study led by Christopher Millett from Imperial College London and the Public Health Foundation of India and colleagues. Their paper reporting the study, published in this week's PLOS Medicine, reveals that cyclists are also less likely to have diabetes or high blood pressure compared to people who take public or private transport to work... (Source: Health News from Medical News Today)

Omega-3 fats from fish oil slash the risk of developing diabetes

NaturalNews.com — Thu, 13 Jun 2013 06:00:00 +0100

New and undiagnosed cases of diabetes continue to rise at epidemic rates, with as many as one in three men, women and children projected to be affected by the metabolic disorder by 2025. The high circulating blood sugar levels associated with diabetes significantly raise... (Source: NaturalNews.com)

Cocoa may help protect against inflammation, diabetes

Health News - UPI.com — Thu, 13 Jun 2013 05:12:00 +0100

STATE COLLEGE, Pa., June 13 (UPI) -- A few cups of hot cocoa may protect against inflammation, which is linked to obesity and diabetes, U.S. researchers say. (Source: Health News - UPI.com)

Activation of the PI3K/Akt pathway by oxidative stress mediates high glucose‐induced increase of adipogenic differentiation in primary rat osteoblasts

Journal of Cellular Biochemistry — Thu, 13 Jun 2013 04:16:17 +0100

Abstract Diabetes mellitus is associated with increased risk of osteopenia and bone fracture that may be related to hyperglycemia. However, the mechanisms accounting for diabetic bone disorder are unclear. Here, we showed that high glucose significantly promoted the production of reactive oxygen species (ROS) in rat primary osteoblasts. Most importantly, we reported for the first time that ROS induced by high glucose increased alkaline phosphatase (ALP) activity, inhibited type I collagen (collagen I) protein level and cell mineralization, as well as gene expression of osteogenic markers including runt‐related transcription factor 2 (Runx2), collagen I, osteocalcin, but promoted lipid droplet formation and gene expression of adipogenic markers including peroxisome proliferator‐activate...

Health‐related quality of life – using the 15D instrument – of young adults with type 1 diabetes since childhood. Population‐based Oulu cohort study of diabetic retinopathy

Acta Ophthalmologica — Thu, 13 Jun 2013 04:00:00 +0100

Conclusion: Young adults with T1D since childhood had 15D HRQoL score equal to that of age‐ and gender‐standardized general population as long as no more severe than nonproliferative DR was present. Presence of PDR, not T1D of long duration per se, significantly impaired the 15D score. (Source: Acta Ophthalmologica)

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BIDMC endocrinology researcher Mark Andermann, Ph.D., named 2013 Pew Scholar

EurekAlert! - Medicine and Health — Thu, 13 Jun 2013 04:00:00 +0100

(Beth Israel Deaconess Medical Center) Mark Andermann, Ph.D., has been named a 2013 Pew Scholar for his work exploring food cues as a new approach to understanding obesity and other eating disorders. (Source: EurekAlert! - Medicine and Health)

From autism to diabetes to Parkinson's disease

EurekAlert! - Medicine and Health — Thu, 13 Jun 2013 04:00:00 +0100

(Pew Health Group) Pew announces its 2013 class of biomedical scholars. (Source: EurekAlert! - Medicine and Health)

Concentric hypertrophic remodelling and subendocardial dysfunction in mitochondrial DNA point mutation carriers

European Journal of Echocardiography — Thu, 13 Jun 2013 04:00:00 +0100

Conclusion Concentric remodelling and subendocardial dysfunction occur in patients carrying m.3243A>G mutation without clinical cardiac disease. Patients with higher mutation loads and disease burden may be at increased risk of cardiac involvement. (Source: European Journal of Echocardiography)

Depression in postmenopausal women may increase diabetes and cardiovascular disease risk

EurekAlert! - Social and Behavioral Science — Thu, 13 Jun 2013 04:00:00 +0100

(University of Massachusetts Medical School) Postmenopausal women who use antidepressant medication or suffer from depression might be more likely to have a higher body mass index, larger waist circumference and inflammation -- all associated with increased risk for diabetes and cardiovascular disease, according to a study led by University of Massachusetts Medical School investigator Yunsheng Ma, Ph.D., M.D., M.P.H. (Source: EurekAlert! - Social and Behavioral Science)

Major hurdle cleared to diabetes transplants

EurekAlert! - Medicine and Health — Thu, 13 Jun 2013 04:00:00 +0100

(Washington University School of Medicine) Researchers at Washington University School of Medicine in St. Louis have identified a way to trigger reproduction in the laboratory of clusters of human cells that make insulin, potentially removing a significant obstacle to transplanting the cells as a treatment for patients with type 1 diabetes. (Source: EurekAlert! - Medicine and Health)

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Coronary artery bypass grafting vs percutaneous coronary intervention in a 'real-world' setting: a comparative effectiveness study based on propensity score-matched cohorts [ADULT CARDIAC]

European Journal of Cardio-Thoracic Surgery — Thu, 13 Jun 2013 04:00:00 +0100

CONCLUSIONS In the ‘real-world’ setting of this study, CABG was associated with significantly lower rates of death, MI and TVR in patients with LMCA or multivessel disease, so it remains the standard of care, particularly for patients with more extensive coronary disease and diabetes. (Source: European Journal of Cardio-Thoracic Surgery)

Recurrence of mediastinal node cancer after lobe-specific systematic nodal dissection for non-small-cell lung cancer [THORACIC]

European Journal of Cardio-Thoracic Surgery — Thu, 13 Jun 2013 04:00:00 +0100

CONCLUSIONS The recurrence of mediastinal node cancer in patients undergoing L-SND was significantly greater than that in those undergoing SND. (Source: European Journal of Cardio-Thoracic Surgery)

Prosthetic knee arthritis due to Granulicatella adiacens after dental cares.

Journal of Medical Microbiology — Thu, 13 Jun 2013 04:00:00 +0100

We report prosthetic knee arthritis in a 55-year-old diabetic man due to Granulicatella adiacens, a microorganism present in the oral flora, usually described in endocarditis but rarely in prosthesis joint infection. This patient had a dental extraction without antibiotic prophylaxis one month before, whereas an aseptic loosening of the prosthesis was previously diagnosed. If antimicrobial prophylaxis against infective endocarditis for dental procedure is well established, such an approach is still controversial for joint prosthesis and must be discussed in some conditions. PMID: 23764743 [PubMed - as supplied by publisher] (Source: Journal of Medical Microbiology)

How do we distinguish loss of vibration sensation due to neuropathy from that due to ageing?

Practical Diabetes International — Thu, 13 Jun 2013 04:00:00 +0100

Abstract The aim of this study was to determine whether loss of sensation in the feet due to diabetic neuropathy can be distinguished from age‐related changes by testing sensation at more proximal sites. Vibration perception threshold (VPT) was tested using a biothesiometer at the feet, mid‐tibia and knees on participants who had a VPT ≥50 volts. We studied: (i) diabetic patients with a history of neuropathic ulceration (N Ulcer+ve); (ii) elderly diabetic patients with no history of ulceration (E Ulcer−ve); and (iii) elderly non‐diabetic controls. The VPT of the N Ulcer+ve group dropped significantly at the level of mid‐tibia and knee and was significantly different from the E Ulcer−ve group at both sites and from the elderly controls at the knee (p ≤ 0.05). By contrast, th...

Which patients with type 2 diabetes attend secondary care clinics?

Practical Diabetes International — Thu, 13 Jun 2013 04:00:00 +0100

Abstract The aim of this study was to investigate the reasons for patients with type 2 diabetes continuing to attend a specialist clinic with an active discharge policy. Clinic letters of 526 patients with type 2 diabetes who attended annual review over one year were audited to identify the major reasons for them remaining in the clinic. The majority of patients (97.3%) fulfilled current specialist clinic criteria for remaining in the clinic. Poor glycaemic control, nephropathy, ongoing changes to management and diabetes foot problems were common reasons found. In 9% of cases, patient choice was identified as a factor. For 2.7% of patients no clear reason could be identified. It was concluded that while most patients fulfilled the criteria to continue attending the clinic at that time, som...

What proportion of patients fail NICE criteria for continuing GLP‐1 treatment beyond six months, and why?

Practical Diabetes International — Thu, 13 Jun 2013 04:00:00 +0100

Abstract Glucagon‐like peptide 1 (GLP‐1) agonist treatment in type 2 diabetes typically improves glycaemic control and results in weight loss. The National Institute for Health and Clinical Excellence (NICE) continuation criteria are that at six months patients must have achieved at least a 3% reduction in weight and an 11mmol/mol (1%) reduction in HbA1c. The St Helens Hospital diabetes team has provided a GLP‐1 service since 2007. As from August 2010, we implemented a new service structure to intensify support to patients, including monthly follow up for the first six months. We assessed NICE continuation criteria in 43 patients who attended since the change in service structure, met NICE initiation criteria and received at least six months' treatment. Mean age was 56 years (SD 10),...

Cranial nerve palsy in diabetes: ‘Hunt’ for the diagnosis

Practical Diabetes International — Thu, 13 Jun 2013 04:00:00 +0100

Abstract A 55‐year‐old diabetic woman presenting with right sixth nerve palsy was diagnosed initially as having diabetic cranial neuropathy. Worsening headache and reported blurring of the right optic disc margin warranted further evaluation. CT scan of the brain was normal and a diagnosis of idiopathic intracranial hypertension was made. Her headache worsened and a partial pupil involving third nerve palsy evolved, at which point she was referred to our institution. Cranial MRI revealed features suggestive of Tolosa‐Hunt syndrome and she responded dramatically to steroid therapy. While third nerve palsy is the most common cranial neuropathy in diabetic patients, sixth nerve palsy merits a wide array of differential diagnoses. A gadolinium‐enhanced MRI of the brain is the preferred...

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Patients' experience of admission to hospital with diabetic ketoacidosis and its psychological impact: an exploratory qualitative study

Practical Diabetes International — Thu, 13 Jun 2013 04:00:00 +0100

Abstract The primary aim of this study was to better understand patients' experience of admission to hospital with diabetic ketoacidosis (DKA) and its psychological impact. The secondary aim was to improve our service provision for patients following an episode of DKA. Forty patients who had been admitted to hospital with DKA were invited to participate. Four patients agreed to take part (three female, one male; mean age 34 years, range 21–49 years). All participants had type 1 diabetes. Participants completed a semi‐structured interview and psychometric questionnaires. Descriptive statistics were generated for demographic and questionnaire data. Interview transcripts were qualitatively analysed using thematic analysis. The thematic analysis showed three important themes: Consequences ...

Cinacalcet

Practical Diabetes International — Thu, 13 Jun 2013 04:00:00 +0100

(Source: Practical Diabetes International)

The Predictive Ability of Triglycerides and Waist (Hypertriglyceridemic Waist) in Assessing Metabolic Triad Change in Obese Children and Adolescents

Metabolic Syndrome and Related Disorders — Thu, 13 Jun 2013 03:05:36 +0100

Metabolic Syndrome and Related Disorders , Vol. 0, No. 0. (Source: Metabolic Syndrome and Related Disorders)

Glucagon Underutilized Among Type 1 Diabetes Mellitus Patients in Japan

Diabetes Technology — Thu, 13 Jun 2013 03:03:11 +0100

Diabetes Technology & Therapeutics , Vol. 0, No. 0. (Source: Diabetes Technology)

Drugmakers to cooperate in safety review of diabetes drugs

Reuters: Health — Wed, 12 Jun 2013 21:24:30 +0100

NEW YORK (Reuters) - Global drugmakers said on Wednesday they would cooperate with an independent review to address concerns of a potential link between widely used diabetes medicines and pancreatic cancer and other safety problems. (Source: Reuters: Health)

Inflammation and Diabetic Cognitive Impairment After CEAInflammation and Diabetic Cognitive Impairment After CEA

Medscape Today Headlines — Wed, 12 Jun 2013 20:18:07 +0100

Preemptive statin administration might ameliorate inflammation and decrease cognitive risk, the study's lead author says. Medscape Medical News (Source: Medscape Today Headlines)

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New service matches patients with clinical-research trials in Orlando

OrlandoSentinel: Medical Research — Wed, 12 Jun 2013 20:07:20 +0100

In Orlando, more than 550 clinical trials are looking for participants to help find better treatments and cures for such chronic diseases as cancer, AIDS and diabetes. Across Florida, nearly 2,500 studies are looking for subjects. "We have a lot of... (Source: OrlandoSentinel: Medical Research)

Cardiovascular risk factors in Children and Adolescents with Congenital Adrenal Hyperplasia due to 21‐hydroxylase Deficiency

Clinical Endocrinology — Wed, 12 Jun 2013 20:05:04 +0100

ConclusionDespite a reduction in steroid doses over the last decade, a number of children with CAH are still obese and hypertensive. Whether this reflects general population trends or indicates a need to further optimise treatment regimens remains to be determined.This article is protected by copyright. All rights reserved. (Source: Clinical Endocrinology)

Go for a walk after you eat

CNN.com - Health — Wed, 12 Jun 2013 20:03:33 +0100

Holly Firfer reports that going for a stroll after we eat may help protect us from type 2 diabetes. (Source: CNN.com - Health)

15-minute walk after each meal may reduce type 2 diabetes risk

Health News - UPI.com — Wed, 12 Jun 2013 19:52:16 +0100

WASHINGTON, June 12 (UPI) -- A 15-minute walk after each meal may help older adults regulate blood-sugar levels and may reduce their risk of type 2 diabetes, U.S. researchers say. (Source: Health News - UPI.com)

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Music device doesn't drop diabetics' blood pressure

Reuters: Health — Wed, 12 Jun 2013 19:27:35 +0100

NEW YORK (Reuters Health) - A device that plays a melody in an attempt to slow people's breathing didn't lower the blood pressure of people with diabetes, according to a new study. (Source: Reuters: Health)

The Red Cell Distribution Width and Anemia in Association With Prevalent Dementia.

Alzheimer Disease and Associated Disorders — Wed, 12 Jun 2013 16:56:20 +0100

Authors: Weuve J, Mendes de Leon CF, Bennett DA, Dong X, Evans DA Abstract The red cell distribution width (RDW), a measure of anisocytosis, independently predicts cardiovascular disease outcomes and chronic disease mortality. Little is known about the RDW, or the interplay between RDW and anemia, in relation to dementia risk. We evaluated the association between the RDW and prevalent dementia, overall and by anemia status, among 2556 community-dwelling older adults participating in the Chicago Health and Aging Project. RDW measurements came from complete blood counts, and participants underwent diagnosis for dementia according to standard clinical criteria. Five hundred twenty-five participants were diagnosed with dementia. Elevated RDW was associated with increased odds of having...

Short walks after meals may help lower risk of Type 2 diabetes

Health News: CBSNews.com — Wed, 12 Jun 2013 16:04:27 +0100

15-minute walks after each meal shown to lower blood sugar better than one 45-minute walk each day (Source: Health News: CBSNews.com)

Short Strolls After Meals May Lower Diabetes Risk

WebMD Health — Wed, 12 Jun 2013 15:59:14 +0100

Walking 15 minutes three times a day was better for blood sugar levels than one 45-minute walk, small study found (Source: WebMD Health)

Severe Hypoglycemia Begets Dementia, and Vice VersaSevere Hypoglycemia Begets Dementia, and Vice Versa

Medscape Today Headlines — Wed, 12 Jun 2013 14:32:02 +0100

A large prospective study finds a bidirectional relationship between severe hypoglycemia and dementia, resulting in a detrimental cycle for patients. Medscape Medical News (Source: Medscape Today Headlines)

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Ultrasound Evaluation and Correlates of Fatty Liver Disease: A Population Study in a Mediterranean Area

Metabolic Syndrome and Related Disorders — Wed, 12 Jun 2013 13:13:38 +0100

Metabolic Syndrome and Related Disorders , Vol. 0, No. 0. (Source: Metabolic Syndrome and Related Disorders)

Preventing Endothelial Dysfunction in Insulin ResistancePreventing Endothelial Dysfunction in Insulin Resistance

Medscape Today Headlines — Wed, 12 Jun 2013 13:05:20 +0100

Can this molecular target be used to delay the onset of vascular disease associated with insulin resistance? Diabetes (Source: Medscape Today Headlines)

Short Strolls After Meals May Lower Diabetes Risk

MedlinePlus Health News — Wed, 12 Jun 2013 13:00:00 +0100

Walking 15 minutes three times a day was better for blood sugar levels than one 45-minute walk, small study found Source: HealthDay Related MedlinePlus Pages: Diabetes, Exercise for Seniors (Source: MedlinePlus Health News)

Merck Welcomes Independent Review of the Safety Profile of JANUVIA® (sitagliptin) and Other Diabetes Medicines

Merck.com - Product News — Wed, 12 Jun 2013 12:00:00 +0100

Dateline City: WHITEHOUSE STATION, N.J. WHITEHOUSE STATION, N.J.--(BUSINESS WIRE)--Merck, known as MSD outside the United States and Canada, today issued the following statement regarding this week's NIDDK-NCI Workshop and the American Diabetes Association’s (ADA) call for an independent review of data about the safety of incretin-based diabetes medicines, including GLP-1 analogs and DPP-4 inhibitors such as JANUVIA® (sitagliptin). Language: English Contact: MerckMedia:Pam Eisele(267) 664-0282orKim Hamilton(908) 391-0131orInvestor:Carol Ferguson(908) 423-4465 Ticker Slug: Ticker: MRK Ex...

Diabetes drug points the way to overcoming drug resistance in melanoma (EurekAlert, 11 June 2013)

Society for Endocrinology — Wed, 12 Jun 2013 12:00:00 +0100

A US-Germany collaboration, published in Cancer Cell, investigates the use of the diabetes drug phenformin in vitro and in mice to improve the efficacy of anti-melanoma drugs against a subpopulation of melanoma cells that exhibit resistance to chemotherapy and a very high metabolic rate. Full article (Source: Society for Endocrinology)

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Radiopeptide therapy improves survival outcomes for neuroendocrine cancer patients (EurekAlert, 10 June 2013)

Society for Endocrinology — Wed, 12 Jun 2013 12:00:00 +0100

A study from Germany presented at the Society of Nuclear Medicine and Molecular Imaging's 2013 Annual Meeting investigates side effects and survival rates of peptide-receptor radionuclide therapy in a total of 450 patients with neuroendocrine tumours selected by prospective national registry. Full article (Source: Society for Endocrinology)

Obesity increases the risk of preterm delivery (AlphaGalileo, 11 June 2013)

Society for Endocrinology — Wed, 12 Jun 2013 12:00:00 +0100

A study from Sweden and the US published in Journal of the American Medical Association assesses risk of preterm delivery according to BMI in 1.5 million singleton deliveries included in the population-based Swedish Medical Birth Register from 1992 through 2010. Full article (Source: Society for Endocrinology)

Stress really may turn your hair grey (ABC News, 10 June 2013)

Society for Endocrinology — Wed, 12 Jun 2013 12:00:00 +0100

A US study published in Nature Medicine describes a melanocortin 1 receptor-dependent migration of hair follicle melanocyte stem cells to the epidermis after wounding or UV exposure in mice. Full article (Source: Society for Endocrinology)

Undergraduate Achievement Award - host a prize for your best undergraduates

Society for Endocrinology — Wed, 12 Jun 2013 12:00:00 +0100

The SfE Undergraduate Achievement Awards provide funding to university departments to encourage excellence in the study of endocrinology by undergraduate students. The award consists of a prize fund of £300/year for three years, and helps departments to provide career development opportunities for their undergraduate students, and highlights the discipline of endocrinology among this group. The prizes must be advertised to the students and must be awarded for a specific piece of work, for example a dissertation/thesis or final exam mark. Reports on the success of the prizes and examples of how they have been awarded, as well as conditions of the grant and how to apply, can be found at the grant website below. The deadline for applications is 15 July 2013. Appl...