MedWorm: Gastroenterology Top 20

New celiac disease-specific quality of life questionnaire developed

MedWire News - Gastroenterology — Fri, 05 Mar 2010 14:19:47 +0100

Researchers have developed a new instrument specifically for measuring quality of life in patients with celiac disease. (Source: MedWire News - Gastroenterology)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Celiac disease is not yet mainstream in endoscopy

Endoscopy — Tue, 02 Mar 2010 14:33:01 +0100

Endoscopy 2010; 42: 218-219DOI: 10.1055/s-0029-1243903© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Full text (Source: Endoscopy)

Drug induced pancreatitis

Best Practice & Research. Clinical Gastroenterology — Sat, 13 Mar 2010 14:21:57 +0100

525 different drugs that can, as an adverse reaction, induce acute pancreatitis are listed in a WHO database. Compared to other causes drugs represent a relatively rare cause of pancreatitis. They should be considered as a triggering event in patients with no other identifiable cause of the disease, who takes medications that have been shown to induce pancreatitis. The prevalence of drug-induced pancreatitis is still unclear because most incidences have been documented only as isolated case reports. The overall incidence probably ranges from between 0.1 and 2% of pancreatitis cases. For only very few substances evidence from controlled trials has been obtained. Epidemiologic data suggest the risk of pancreatitis is highest for mesalazine (HR 3.5,) azathioprine (HR 2,5) and simvastatine (HR...

IBD inpatients at increased risk for MRSA infection

MedWire News - Gastroenterology — Mon, 01 Mar 2010 15:04:10 +0100

Hospitalized patients with inflammatory bowel disease are at increased risk for contracting methicillin-resistant Staphylococcus aureus infection compared with non-IBD gastrointestinal and general inpatients, show Canadian researchers. (Source: MedWire News - Gastroenterology)

Celiac disease in Brazilian patients: associations, complications and causes of death. Forty years of clinical experience

Arquivos de Gastroenterologia — Sat, 13 Mar 2010 14:23:58 +0100

Conclusions - This experience is similar to those described in the world literature. Celiac disease presents the same characteristics independently of the geographic region. We recommend periodic evaluations, from childhood, independent of the duration of the diet. The key is to establish an interval between evaluations.CONTEXTO: A doença celíaca é uma enfermidade multissistêmica e autoimune que pode se manifestar em qualquer idade, em indivíduos geneticamente predispostos. OBJETIVO: Identificação das associações, complicações e causas de morte em pacientes brasileiros após longo período de acompanhamento. MÉTODOS: Foram estudados retrospectivamente 157 pacientes, 23 adolescentes e 134 adultos, 79,6% do sexo feminino e 20,4% do masculino, 75,8% ao diagnóstico e 24,2% em diet...

Critically Ill Patients With H1N1 And Gastrointestinal Absorption Of Tamiflu

GastroIntestinal News From Medical News Today — Wed, 17 Feb 2010 13:00:00 +0100

An increased dosage of Tamiflu (oseltamivir) for patients with critical illness is unlikely to be required in the treatment of pandemic (H1N1) influenza, contrary to current international guidelines, found a new study http://www.cmaj.ca/cgi/doi/10.1503/cmaj.092127 in CMAJ (Canadian Medical Association Journal) http://www.cmaj.ca... (Source: GastroIntestinal News From Medical News Today)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Any Second-Line Therapy for Advanced Pancreatic Cancer? Highlights from the "2010 ASCO Gastrointestinal Cancers Symposium". Orlando, FL, USA. January 22-24, 2010.

JOP — Wed, 10 Mar 2010 20:50:03 +0100

Authors: Li J, Merl MY, Saif MW Majority of pancreatic cancers are unresectable upon diagnosis. Palliative chemotherapy is usually administered in an attempt of prolonging survival potentially and providing quality of life. Gemcitabine has been the solo player in the field of pancreatic cancer treatment after replacing 5-FU since 1997. How to treat a patient with advanced pancreatic cancer failing to respond or progressing after gemcitabine is a true challenge. No established second-line treatment exists yet. Chinese herbal medicine PHY906 provides cytoprotective effects without dampening the anti-tumor activity of chemotherapeutic agents. Several combinations such as S-1/gemcitabine, GTX, FOLFIRINOX showed promising results in retrospective studies. Among single agents, erlotinib and ...

Coeliac disease: emerging in China?

Gut — Fri, 05 Mar 2010 11:12:52 +0100

(Source: Gut)

Acidic perfusion provokes DIS without heartburn in healthy individuals

MedWire News - Gastroenterology — Wed, 03 Mar 2010 14:28:56 +0100

Researchers have found that, although weakly acidic solutions can provoke dilated intercellular spaces in healthy individuals after esophageal perfusion, most of these individuals do not experience heartburn or pain, suggesting that non-erosive reflux disease patients have other critical factors underlying their symptoms. (Source: MedWire News - Gastroenterology)

Lysosomal accumulation of gliadin p31-43 peptide induces oxidative stress and tissue transglutaminase-mediated PPAR{gamma} downregulation in intestinal epithelial cells and coeliac mucosa

Gut — Fri, 05 Mar 2010 11:12:51 +0100

Conclusion p31–43 accumulation in lysosomes leads to epithelial activation via the ROS–TG2 axis. TG2 works as a rheostat of ubiquitination and proteasome degradation and drives inflammation via PPAR downregulation. (Source: Gut)

Celiac Disease Genes Identified In Immune System

GastroIntestinal News From Medical News Today — Mon, 01 Mar 2010 11:00:00 +0100

A UK-led international study has identified four types of genetic disturbance in the immune system that lead to celiac disease, bringing to 40 the total number of known inherited factors that increase a person's risk of developing the disease... (Source: GastroIntestinal News From Medical News Today)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Diagnostic value of confocal endomicroscopy in celiac disease

Endoscopy — Tue, 02 Mar 2010 14:33:01 +0100

Endoscopy 2010; 42: 197-202DOI: 10.1055/s-0029-1243937 Improved endoscopic screening with targeted biopsies might enhance diagnostic yield in celiac disease. Confocal endomicroscopy (CEM) allows high-resolution in vivo histological analysis. We compared the endomicroscopic findings during ongoing endoscopy with the histological findings graded according to the Marsh classification.[...]© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Abstract | Full text (Source: Endoscopy)

In Adults With Celiac Disease, Intestinal Damage Doesn't Always Heal

Medscape Gastroenterology Headlines — Fri, 05 Mar 2010 16:45:00 +0100

When celiac disease is diagnosed in adulthood, mucosal damage might never completely resolve, even on a gluten-free diet, according to a February 9th online report in The American Journal of Gastroenterology. Reuters Health Information (Source: Medscape Gastroenterology Headlines)

Moderate alcohol consumption may facilitate H. pylori elimination

MedWire News - Gastroenterology — Mon, 15 Feb 2010 14:18:31 +0100

Moderate alcohol consumption may facilitate the elimination of Helicobacter pylori, suggest researchers who found an inverse association between alcohol consumption and H. pylori seropositivity. (Source: MedWire News - Gastroenterology)

Modified RECIST (mRECIST) Assessment for Hepatocellular Carcinoma

Seminars in Liver Disease — Sat, 20 Feb 2010 14:23:38 +0100

Semin Liver Dis 2010; 30: 052-060DOI: 10.1055/s-0030-1247132ABSTRACTThe endpoint in cancer research is overall survival. Nonetheless, other potential surrogate endpoints, such as response rate and time to progression, are currently used. Measurement of response rate in hepatocellular carcinoma (HCC) has become a controversial issue. The World Health Organization (WHO) criteria underestimate the actual response rate; thus, they were amended in 2000 by a panel of experts convened by the European Association for the Study of the Liver (EASL) to take into account treatment-induced tumor necrosis. Applying these guidelines, there was an association between response rate and outcome prediction. More recently, the Response Evaluation Criteria in Solid Tumors (RECIST) guideline was proposed as a m...

Prescreening of a High-Risk Group for Gastric Cancer by Serologically Determined Helicobacter pylori Infection and Atrophic Gastritis

Digestive Diseases and Sciences — Wed, 10 Mar 2010 18:48:04 +0100

Conclusions A high-risk group for gastric cancer can be selected by serological prescreening. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10620-010-1154-0Authors Shigeto Mizuno, Kobe Pharmaceutical University Department of Medical Pharmaceutics 4-19-1 Motoyama-kita, Higashinada-ku Kobe 658-8558 JapanIkuya Miki, Kobe Pharmaceutical University Department of Medical Pharmaceutics 4-19-1 Motoyama-kita, Higashinada-ku Kobe 658-8558 JapanTsukasa Ishida, Kobe Pharmaceutical University Department of Medical Pharmaceutics 4-19-1 Motoyama-kita, Higashinada-ku Kobe 658-8558 JapanMasaru Yoshida, Kobe University Division of Gastroenterology, Graduate School of Medicine 7-5-2 Kusunoki-cho, Chuo-ku Kobe 650-0017 JapanMitsuko Onoyama, Kobe University Division of G...

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Management of Skin Toxicities of Anti-EGFR Agents in Patients with Pancreatic Cancer and Other GI Tumors by Using Electronic Communication: Effective and Convenient.

JOP — Wed, 10 Mar 2010 20:50:03 +0100

Authors: Saif MW, Kaley K, Lamb L, Pecerillo J, Hotchkiss S, Steven L, Brennan M, Penney R, Gillespie C, Shaib W Erlotinib has been FDA approved to be used in combination with gemcitabine as the first line treatment in advanced pancreatic cancer patients. Skin rash has been documented as one of the commonest adverse reactions in patients receiving erlotinib and other EGFR inhibitors. Draw back to this reaction leads to: 1) drug discontinuation or dose reduction; 2) impairs quality of life; and 3) Puts patients at risk of superinfection. Monitoring patients closely and initiating immediate skin care is recommended. However, patients forget how the rash started and when. No standard treatments exist secondary to the diversity of symptoms, variability and intermittent occurrence in relati...

Endocytotic segregation of gliadin peptide 31-49 in enterocytes

Gut — Fri, 05 Mar 2010 11:12:51 +0100

Conclusions Endocytic segregation of gliadin peptide AA 31–49 seems to be a constitutive process. It explains why this peptide cannot stimulate gluten-sensitive T cells. Presentation of gliadin peptides by HLA-DR proteins via late endosomes within enterocytes might induce a tolerogenic effect and constitutes a potentially promising therapeutic approach for induction of tolerance towards gliadin. (Source: Gut)

EASL Clinical School of Hepatology Course 14: Metabolic Liver Disease

NLH - Gastroenterology & Liver Diseases - Events — Wed, 03 Mar 2010 14:29:56 +0100

(Source: NLH - Gastroenterology & Liver Diseases - Events)

Cell-Culture And Animal Tests Show Antiviral Could Provide Protection Against HIV, Ebola, Hepatitis C, Herpes And More

Liver Disease / Hepatitis News From Medical News Today — Wed, 03 Feb 2010 08:00:00 +0100

The development of antibiotics gave physicians seemingly miraculous weapons against infectious disease. Effective cures for terrible afflictions like pneumonia, syphilis and tuberculosis were suddenly at hand. Moreover, many of the drugs that made them possible were versatile enough to knock out a wide range of deadly bacterial threats... (Source: Liver Disease / Hepatitis News From Medical News Today)