MedWorm: Gastroenterology Top 20

Development of an internet‐based cohort of patients with inflammatory bowel diseases (CCFA Partners): Methodology and initial results

Inflammatory Bowel Diseases — Sun, 29 Jan 2012 21:08:39 +0100

Conclusions:CCFA Partners is a novel e‐cohort. Enrollment is ongoing, with surveys twice yearly. CCFA Partners represents a unique resource to study PROs and changes in disease management over time. (Inflamm Bowel Dis 2012;) (Source: Inflammatory Bowel Diseases)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Visceral adipose tissue in Crohn's disease: Satan or samaritan?

Inflammatory Bowel Diseases — Thu, 26 Jan 2012 21:26:46 +0100

(Source: Inflammatory Bowel Diseases)

Prognosis of lymphoma in patients following treatment with 6‐mercaptopurine/azathioprine for inflammatory bowel disease

Inflammatory Bowel Diseases — Sat, 14 Jan 2012 06:30:22 +0100

Conclusions:We found no differences of survival with lymphoma between IBD patients and expected survival for the general population. Also, the prognosis for those IBD patients treated with 6‐MP/AZA was not worse than lymphoma patients not treated with 6‐MP/AZA. Statistical analysis, however, was limited by the small sample size and heterogeneity of the patients studied. (Inflamm Bowel Dis 2012;) (Source: Inflammatory Bowel Diseases)

Technical description of a regional lymphadenectomy in radical surgery for gallbladder cancer

HPB: official journal of the International Hepato Pancreat Biliary Association — Sun, 29 Jan 2012 20:47:58 +0100

Conclusion: A systematic approach towards a regional lymphadenectomy ensures a consistent nodal harvest in patients undergoing radical resection for gallbladder cancer. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)

Do thiopurines prevent advanced colorectal neoplasia in patients with inflammatory bowel disease or is this an unanswerable question?

Inflammatory Bowel Diseases — Mon, 23 Jan 2012 21:06:55 +0100

(Source: Inflammatory Bowel Diseases)

Upregulation of mucosal 5‐HT3 receptors is involved in restoration of colonic transit after pelvic nerve transection

Neurogastroenterology and Motility — Sun, 05 Feb 2012 20:39:57 +0100

Conclusions & Inferences Colonic motility was restored to approximately 70% normal over 1 week without further improvement at 2 weeks. Enteric nervous system compensated by upregulating mucosal 5‐HT3, but not 5‐HT4, receptors. (Source: Neurogastroenterology and Motility)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Urgency of referral and its impact on outcomes in patients with colorectal cancer

Colorectal Disease — Sun, 29 Jan 2012 21:01:36 +0100

Conclusion: Urgency of referral decreased the time to diagnosis. This did not influence resection rates. Dukes’ stage was higher for urgent referrals. Long term follow up is required to determine any impact on survival. (Source: Colorectal Disease)

Journal of Hepatology — Tue, 17 Jan 2012 22:04:56 +0100

(Source: Journal of Hepatology)

Is KRAS Mutation Associated with Interval Colorectal Cancers?

Digestive Diseases and Sciences — Fri, 02 Dec 2011 17:26:36 +0100

Conclusions KRAS mutation is inversely associated with interval cancers and with MSI, suggesting that it is a marker of the chromosomal instability pathway associated with slow tumor growth, and distinct from MSI rapidly growing cancers. Molecular characterization of colorectal cancers is helpful in determining underlying pathway and may determine therapy. Content Type Journal ArticleCategory Original ArticlePages 1-5DOI 10.1007/s10620-011-1974-6Authors Aasma Shaukat, Division of Gastroenterology, VA Medical Center, University of Minnesota, One-Veterans Drive, 111-D, Minneapolis, MN 55417, USAMustafa Arain, Division of Gastroenterology, VA Medical Center, University of Minnesota, One-Veterans Drive, 111-D, Minneapolis, MN 55417, USARuth Anway, Division of Gastroen...

Excess primary intestinal lymphoproliferative disorders in patients with inflammatory bowel disease

Inflammatory Bowel Diseases — Mon, 23 Jan 2012 05:00:00 +0100

Conclusions:Patients with IBD have an increased risk of developing PILD. (Inflamm Bowel Dis 2012;) (Source: Inflammatory Bowel Diseases)

Suppression of esophageal cancer cell growth using curcumin, (-)-epigallocatechin-3-gallate and lovastatin.

World Journal of Gastroenterology : WJG — Sat, 14 Jan 2012 05:00:00 +0100

CONCLUSION: The combinations of curcumin, EGCG and lovastatin were able to suppress esophageal cancer cell growth in vitro and in nude mouse xenografts, these drugs also inhibited phosphorylated Erk1/2, c-Jun and COX-2 expression. PMID: 22253518 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Is Ulcerative Colitis Associated with Survival Among Older Persons with Colorectal Cancer in the US? A Population-Based Case–Control Study

Digestive Diseases and Sciences — Wed, 23 Nov 2011 17:37:53 +0100

Conclusions Colorectal cancers tend to be diagnosed at earlier stages among persons with UC, but there is no difference in 3-year survival rates for colorectal cancer among individuals with and without UC. Content Type Journal ArticleCategory Original ArticlePages 1-5DOI 10.1007/s10620-011-1966-6Authors Aasma Shaukat, Section of Gastroenterology, VA Medical Center, University of Minnesota, Gastroenterology Section 111-D, 1-Veterans Drive, Minneapolis, MN 55417, USANadim I. Salfiti, Section of Gastroenterology, VA Medical Center, University of Minnesota, Gastroenterology Section 111-D, 1-Veterans Drive, Minneapolis, MN 55417, USADaniel J. Virnig, Section of Gastroenterology, VA Medical Center, University of Minnesota, Gastroenterology Section 111-D, 1-Veterans Driv...

A rare gastrointestinal presentation of a common malignancy

Gut — Fri, 03 Feb 2012 05:00:00 +0100

Clinical presentation A 61-year-old man presented with a 4-week history of rectal bleeding, constipation, bloating, abdominal distension and low back pain. His bowels had not opened for 4 days prior to admission. Physical examination revealed a distended, tympanic abdomen. Routine laboratory tests confirmed renal failure (urea 13 mmol/l, creatinine 200 μmol/l), hypercalcaemia (3.7 mmol/l), albumin 32 g/l and C-reactive protein (CRP) 25 mg/l. Parathormone was suppressed (7 pg/l (15–65)). Abdominal x-ray suggested an ileus. CT abdomen revealed mural thickening of the left hemi-colon along with collapse of the third lumbar vertebra. An isotope bone scan was unremarkable, while MRI of the spine confirmed the presence of multiple lytic lesions. Immuno...

Functional Disorders after Rectal Cancer Resection: Does a Rehabilitation Program Improve Anal Continence and Quality of Life?

Colorectal Disease — Mon, 23 Jan 2012 20:58:46 +0100

Conclusion: This study suggests that anal sphincter training following TME could decrease stool frequency and improve both general and specific quality of life. (Source: Colorectal Disease)

Copyright Assignment, Authorship Responsibility, NIH Funding, Financial Disclosure, Institutional Review Board/Animal Care Committee Approval, and Sponsorship

Gastroenterology — Thu, 26 Jan 2012 21:26:23 +0100

Copyright Assignment. In consideration of the American Gastroenterological Association (AGA) Institute (the “AGA Institute”) taking action to review and credit the below-identified submission (the “Manuscript”), and for other valuable consideration, the receipt and sufficiency of which is hereby acknowledged, the undersigned authors and/or creators (the “Authors”), jointly and severally, hereby transfer, convey, and assign to the AGA Institute, free and clear of any liens, licenses or encumbrances, the entire right, title, and interest in and to the Manuscript throughout the world, including without limitation in and to any and all copyrights for the Manuscript (including but not limited to rights to copy, publish, excerpt, collect royalties and make derivative works) in print,...

Use of endoscopic ultrasound in diagnosing plasmacytoma of the pancreas.

JOP — Sun, 01 Jan 2012 05:00:00 +0100

Conclusion It is important for physicians to have a high index of suspicion for diagnosing pancreatic plasmacytomas in the appropriate clinical setting (i.e., a previously diagnosed multiple myeloma, extramedullary plasmacytoma or any other plasma cell neoplasm). EUS-FNA is now an indispensable imaging modality to achieve the diagnosis of pancreatic extramedullary plasmacytomas with an inherently lower rate of complications, and should be the first choice for tissue evaluation. PMID: 22233943 [PubMed - in process] (Source: JOP)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Changes of the HSD17B10 gene expression levels in ulcerative colitis

Inflammatory Bowel Diseases — Mon, 23 Jan 2012 05:00:00 +0100

(Source: Inflammatory Bowel Diseases)

Can endoscopy be avoided in the assessment of ulcerative colitis in clinical trials?

Inflammatory Bowel Diseases — Mon, 23 Jan 2012 05:00:00 +0100

Conclusions:The Mayo score can be accurately predicted from the partial Mayo score. A noninvasive index can replace the Mayo score in future clinical trials. (Inflamm Bowel Dis 2012;) (Source: Inflammatory Bowel Diseases)

Delayed gastric emptying rates and impaired antral motility in children fulfilling Rome III criteria for functional abdominal pain

Neurogastroenterology and Motility — Wed, 25 Jan 2012 05:00:00 +0100

Conclusions & Inferences Gastric emptying rate and antral motility parameters were significantly impaired in patients with FAP and GER negatively correlated with symptom severity. These findings highlight the possible role of gastrointestinal motility abnormalities in the pathophysiology of childhood FAP. (Source: Neurogastroenterology and Motility)

Future directions in esophageal motility and function – new technology and methodology

Neurogastroenterology and Motility — Tue, 17 Jan 2012 21:39:59 +0100

AbstractBackground Symptom based diagnosis is not reliable in patients with swallowing problems, heartburn, and other dyspeptic complaints. The aim of investigation is to provide clinically relevant measurements of gastrointestinal structure and function that explain the cause of symptoms, identify pathology, and guide effective management. Current practice rarely meets these ideals.Purpose This review considers recent advances in technology such as high‐resolution manometry (HRM) with esophageal pressure topography (EPT), HRM with impedance, high frequency ultrasound, and endoscopic functional luminal impedance planimetry (Endo‐FLIP) that provide new opportunities to identify the pathophysiologic basis of esophageal symptoms and disease. As experience with these new devices incr...

MedWorm: Gastroenterology Top 20

Development of an internet‐based cohort of patients with inflammatory bowel diseases (CCFA Partners): Methodology and initial results

Visceral adipose tissue in Crohn's disease: Satan or samaritan?

Prognosis of lymphoma in patients following treatment with 6‐mercaptopurine/azathioprine for inflammatory bowel disease

Technical description of a regional lymphadenectomy in radical surgery for gallbladder cancer

Do thiopurines prevent advanced colorectal neoplasia in patients with inflammatory bowel disease or is this an unanswerable question?

Upregulation of mucosal 5‐HT3 receptors is involved in restoration of colonic transit after pelvic nerve transection

Urgency of referral and its impact on outcomes in patients with colorectal cancer

Contents

Is KRAS Mutation Associated with Interval Colorectal Cancers?

Excess primary intestinal lymphoproliferative disorders in patients with inflammatory bowel disease

Suppression of esophageal cancer cell growth using curcumin, (-)-epigallocatechin-3-gallate and lovastatin.

Is Ulcerative Colitis Associated with Survival Among Older Persons with Colorectal Cancer in the US? A Population-Based Case–Control Study

A rare gastrointestinal presentation of a common malignancy

Functional Disorders after Rectal Cancer Resection: Does a Rehabilitation Program Improve Anal Continence and Quality of Life?

Copyright Assignment, Authorship Responsibility, NIH Funding, Financial Disclosure, Institutional Review Board/Animal Care Committee Approval, and Sponsorship

Use of endoscopic ultrasound in diagnosing plasmacytoma of the pancreas.

Changes of the HSD17B10 gene expression levels in ulcerative colitis

Can endoscopy be avoided in the assessment of ulcerative colitis in clinical trials?

Delayed gastric emptying rates and impaired antral motility in children fulfilling Rome III criteria for functional abdominal pain

Future directions in esophageal motility and function – new technology and methodology