MedWorm: Gastroenterology

Endoscopic augmentation of the lower oesophageal sphincter using hydrogel implants for the treatment of gastro-oesophageal reflux disease

Gastroenterology and Liver Diseases Specialist Library - Oesophagus — Fri, 20 Nov 2009 14:03:23 +0100

A record from the CRD Health Techology Assessment Database. Published in July 2009. (Source: Gastroenterology and Liver Diseases Specialist Library - Oesophagus)

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Selective cell apheresis in inflammatory bowel disease

Fri, 20 Nov 2009 10:39:15 +0100

A record from the CRD Health Techology Assessment Database. Published in September 2009. (Source: Gastroenterology and Liver Diseases Specialist Library - Inflammatory bowel disease)

Dynavax Completes Enrollment Of First Cohort Of Patients In Phase 1b Clinical Trial For Hepatitis B Therapy

Liver Disease / Hepatitis News From Medical News Today — Fri, 20 Nov 2009 10:00:00 +0100

Dynavax Technologies Corporation (NASDAQ: DVAX) announced today that enrollment has been completed for the first of three cohorts of patients receiving DV-601 hepatitis B therapy in a Phase 1b clinical trial. The safety profile of patients in the first cohort met pre-specified criteria for dose escalation and the second cohort has been opened for enrollment. Dynavax expects to report top-line data from this trial in the second half of 2010. (Source: Liver Disease / Hepatitis News From Medical News Today)

Toward Explaining Why Hepatitis B Hits Men Harder Than Women

Liver Disease / Hepatitis News From Medical News Today — Fri, 20 Nov 2009 10:00:00 +0100

Scientists in China are reporting discovery of unusual liver proteins, found only in males, that may help explain the long-standing mystery of why the hepatitis B virus (HBV) sexually discriminates -- hitting men harder than women. Their study has been published online in ACS' Journal of Proteome Research, a monthly publication. (Source: Liver Disease / Hepatitis News From Medical News Today)

What medical and economical benefit has the examination of the helicobacter pylori population via urea respiratory test in primary diagnostics

Gastroenterology and Liver Diseases Specialist Library - Stomach — Fri, 20 Nov 2009 09:57:49 +0100

A record from the CRD Health Techology Assessment Database. Published in June 2009. (Source: Gastroenterology and Liver Diseases Specialist Library - Stomach)

Cancer antigen 19-9 for prognosis of pancreatic cancer resectability

Gastroenterology and Liver Diseases Specialist Library - Pancreas — Fri, 20 Nov 2009 09:56:36 +0100

A record from the CRD Health Techology Assessment Database. Published in July 2009. (Source: Gastroenterology and Liver Diseases Specialist Library - Pancreas)

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What medical and economical benefit has the examination of the helicobacter pylori population via urea respiratory test in primary diagnostics

Gastroenterology and Liver Diseases Specialist Library - Diagnostic procedures — Fri, 20 Nov 2009 09:49:37 +0100

A record from the CRD Health Techology Assessment Database. Published in June 2009. (Source: Gastroenterology and Liver Diseases Specialist Library - Diagnostic procedures)

Screening for colorectal cancer

Gastroenterology and Liver Diseases Specialist Library - Colon and rectum — Fri, 20 Nov 2009 09:44:25 +0100

A record from the CRD Health Techology Assessment Database. Published in July 2009. (Source: Gastroenterology and Liver Diseases Specialist Library - Colon and rectum)

Genzyme Announces Results Of Phase 2/3 Trial Of Advanced Phosphate Binder

GastroIntestinal News From Medical News Today — Fri, 20 Nov 2009 09:00:00 +0100

Genzyme Corporation (Nasdaq: GENZ) reported results of a phase 2/3 study of its advanced phosphate binder (APB). The trial met its primary endpoint, which was to show that the APB lowered phosphate levels effectively compared to placebo. However, the APB did not show a significant improvement in phosphate lowering compared to Genzyme's Renvela® (sevelamer carbonate). Based on these results, the company is not planning to pursue further clinical development of the APB. (Source: GastroIntestinal News From Medical News Today)

Why Hepatitis B Hits Men Harder Than Women

Liver Disease / Hepatitis News From Medical News Today — Fri, 20 Nov 2009 08:00:00 +0100

TACE it or leave it: hard choices for intermediate-stage hepatocellular carcinoma patients beyond perfect health

Liver International — Fri, 20 Nov 2009 00:00:00 +0100

(Source: Liver International)

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Do we need an 'in-house' neutralization assay for confirmation of hepatitis B surface antigen? Answers from a tertiary care hospital in India

Journal of Gastroenterology and Hepatology — Fri, 20 Nov 2009 00:00:00 +0100

Conclusion: The enzyme immunoassay-based 'in-house' HBsAg neutralization assay is a feasible alternative to the commercial HBsAg confirmatory assay. This technique is easily adaptable, cost-effective and reliable for the confirmation of HBsAg in a low resource setting, enhancing the overall quality of HBsAg screening. (Source: Journal of Gastroenterology and Hepatology)

Distribution of Helicobacter pylori virulence markers in patients with gastroduodenal diseases in Pakistan

BMC Gastroenterology — Fri, 20 Nov 2009 00:00:00 +0100

Background: Helicobacter pylori (H. pylori) infection is known to be associated with a spectrum of gastroduodenal diseases. We studied the association of H. pylori virulence markers cytotoxin-associated gene (cagA) and vacuolating associated cytotoxin gene (vacA) alleles in patients with non ulcer dyspepsia (NUD), gastric ulcer (GU), gastric carcinoma (GC) and duodenal ulcer (DU). Methods: H. pylori infection established by both rapid urease test and histology were studied. The cagA and vacA allelic status was determined by polymerase chain reaction (PCR). Sequencing of vacA i1 and i2 PCR product was carried out. Results: Two hundred and twenty-four patients were included, 141 (63%) were males with a mean age of 45+/- 16, range 16-83 years. The virulence marker cagA was associated with GU ...

Axel Grothey, MD - Modifying Treatment, Maximizing Benefit: A Case-Based Exploration of Advanced CRC Management

Peerview CME/CE Video Podcast - Gastroenterology — Thu, 19 Nov 2009 18:59:52 +0100

Please be sure to view the accompanying (PDF) file for full CME/CNE/CPE information. (Source: Peerview CME/CE Video Podcast - Gastroenterology)

Axel Grothey, MD - Modifying Treatment, Maximizing Benefit: A Case-Based Exploration of Advanced CRC Management

PeerView CME/CE Audio Podcast - Gastroenterology — Thu, 19 Nov 2009 18:59:52 +0100

Please be sure to view the accompanying (PDF) file for full CME/CNE/CPE information. (Source: PeerView CME/CE Audio Podcast - Gastroenterology)

CME/CNE/CPE - Modifying Treatment, Maximizing Benefit: A Case-Based Exploration of Advanced CRC Management

Peerview CME/CE Video Podcast - Gastroenterology — Thu, 19 Nov 2009 18:59:46 +0100

Please view this PDF file for full CME/CNE/CPE information. You will need Adobe Acrobat reader software to access this file. (Source: Peerview CME/CE Video Podcast - Gastroenterology)

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CME/CNE/CPE - Modifying Treatment, Maximizing Benefit: A Case-Based Exploration of Advanced CRC Management

PeerView CME/CE Audio Podcast - Gastroenterology — Thu, 19 Nov 2009 18:59:46 +0100

Please view this PDF file for full CME/CNE/CPE information. You will need Adobe Acrobat reader software to access this file. (Source: PeerView CME/CE Audio Podcast - Gastroenterology)

Vardenafil: A Potential Drug To Protect Gastric Mucosa

GastroIntestinal News From Medical News Today — Thu, 19 Nov 2009 14:00:00 +0100

Indomethacin has been proved by epidemiological and experimental studies to be closely associated with peptic ulcer development. Vardenafil is a potent phosphodiesterase 5 inhibitor and its effects on the gastric mucosa have not been reported. A research article published in the World Journal of Gastroenterology addresses this problem. The research team, led by Dr. (Source: GastroIntestinal News From Medical News Today)

The Antifibrotic Effects Of Green Tea

Liver Disease / Hepatitis News From Medical News Today — Thu, 19 Nov 2009 13:00:00 +0100

Several studies have shown that lipid peroxidation stimulates collagen production in fibroblasts and hepatic stellate cells (HSC), and plays an important role in the development of liver fibrosis. Hepatoprotective effects of green tea against carbon tetrachloride, cholestasis and alcohol induced liver fibrosis were reported in many studies. However, the hepatoprotective effect of green tea in dimethylnitrosamine (DMN)-induced models has not been studied. (Source: Liver Disease / Hepatitis News From Medical News Today)

Unexplained Liver Hemorrhage After Metastasis Radiofrequency Ablation

Liver Disease / Hepatitis News From Medical News Today — Thu, 19 Nov 2009 13:00:00 +0100

Colorectal carcinoma is one of the most common cancers in the world. Approximately one in four of these patients have metastases at diagnosis, liver being the most common site involved. Although historically it was considered that liver metastases meant a very poor prognosis, today, due to improved systemic therapy, many patients will be candidates for local hepatic treatments such as surgery or less aggressive radiofrequency ablation. (Source: Liver Disease / Hepatitis News From Medical News Today)

Identifying The Factors Related To Bile Output And Reduction Of Serum Bilirubin After Percutaneous Transhepatic Biliary Drainage

GastroIntestinal News From Medical News Today — Thu, 19 Nov 2009 13:00:00 +0100

Biliary drainage is performed as a palliative treatment of hilar cholangiocarcinoma. The reduction of serum bilirubin is usually the hallmark of successful biliary drainage. However, some patients may have persistent jaundice or scanty bile output after biliary drainage. A research team, led by Dr. (Source: GastroIntestinal News From Medical News Today)

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Health Tip: When Infants Get Diarrhea

MedicineNet Crohn's Disease General — Thu, 19 Nov 2009 07:00:00 +0100

Title: Health Tip: When Infants Get DiarrheaCategory: Health NewsCreated: 11/19/2009 8:10:00 AMLast Editorial Review: 11/19/2009 (Source: MedicineNet Crohn's Disease General)

Morphine May Help Tumors Spread in Cancer Patients

MedicineNet Crohn's Disease General — Thu, 19 Nov 2009 07:00:00 +0100

Title: Morphine May Help Tumors Spread in Cancer PatientsCategory: Health NewsCreated: 11/18/2009 12:10:00 PMLast Editorial Review: 11/19/2009 (Source: MedicineNet Crohn's Disease General)

Gene Mutations Linked to IBD in Children

MedicineNet Crohn's Disease General — Thu, 19 Nov 2009 07:00:00 +0100

Title: Gene Mutations Linked to IBD in ChildrenCategory: Health NewsCreated: 11/19/2009 10:36:00 AMLast Editorial Review: 11/19/2009 10:36:15 AM (Source: MedicineNet Crohn's Disease General)

Genome-wide association studies--a summary for the clinical gastroenterologist.

World Journal of Gastroenterology : WJG — Thu, 19 Nov 2009 04:12:47 +0100

Authors: Melum E, Franke A, Karlsen TH Genome-wide association studies (GWAS) have been applied to various gastrointestinal and liver diseases in recent years. A large number of susceptibility genes and key biological pathways in disease development have been identified. So far, studies in inflammatory bowel diseases, and in particular Crohn's disease, have been especially successful in defining new susceptibility loci using the GWAS design. The identification of associations related to autophagy as well as several genes involved in immunological response will be important to future research on Crohn's disease. In this review, key methodological aspects of GWAS, the importance of proper cohort collection, genotyping issues and statistical methods are summarized. Ways of addressing the ...

Peutz-Jeghers syndrome: diagnostic and therapeutic approach.

World Journal of Gastroenterology : WJG — Thu, 19 Nov 2009 04:12:44 +0100

Authors: Kopacova M, Tacheci I, Rejchrt S, Bures J Peutz-Jeghers syndrome (PJS) is an inherited, autosomal dominant disorder distinguished by hamartomatous polyps in the gastrointestinal tract and pigmented mucocutaneous lesions. Prevalence of PJS is estimated from 1 in 8300 to 1 in 280,000 individuals. PJS predisposes sufferers to various malignancies (gastrointestinal, pancreatic, lung, breast, uterine, ovarian and testicular tumors). Bleeding, obstruction and intussusception are common complications in patients with PJS. Double balloon enteroscopy (DBE) allows examination and treatment of the small bowel. Polypectomy using DBE may obviate the need for repeated urgent operations and small bowel resection that leads to short bowel syndrome. Prophylaxis and polypectomy of the entire sm...

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Gastric ghrelin in relation to gender, stomach topography and Helicobacter pylori in dyspeptic patients.

World Journal of Gastroenterology : WJG — Thu, 19 Nov 2009 04:12:41 +0100

CONCLUSION: An increase in gastric ghrelin levels at the stage of non-atrophic gastritis in H pylori positive patients, especially in those infected with cagA(-) strains, can exert a gastroprotective effect. PMID: 19916170 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

Effect of growth hormone on small intestinal homeostasis relation to cellular mediators IGF-I and IGFBP-3.

World Journal of Gastroenterology : WJG — Thu, 19 Nov 2009 04:12:38 +0100

CONCLUSION: These findings confirm the important trophic and protective role of GH in the homeostasis of the small intestine. The trophic effect is mediated by an increase in IGF-I synthesis in the small intestine, but the protective effect is not related to IGF-I. PMID: 19916171 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

Expression and localization of Wolfram syndrome 1 gene in the developing rat pancreas.

World Journal of Gastroenterology : WJG — Thu, 19 Nov 2009 04:12:36 +0100

CONCLUSION: These results indicate that WFS1 may be involved in some aspects of pancreatic development and further research on WFS1 may provide new evidences to prove the interactions between mesenchyma and epithelia at the same time. PMID: 19916172 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

Effects of angiopoietin-1 on attachment and metastasis of human gastric cancer cell line BGC-823.

World Journal of Gastroenterology : WJG — Thu, 19 Nov 2009 04:12:33 +0100

CONCLUSION: Transfection of Ang-1 into human gastric cancer cell line BGC-823 can significantly increase expression of integrin beta1 and CD44V6, by which cell adhesion and metastasis to the ECM are promoted. PMID: 19916173 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

Stable knockdown of heparanase expression in gastric cancer cells in vitro.

World Journal of Gastroenterology : WJG — Thu, 19 Nov 2009 04:12:30 +0100

CONCLUSION: Stable knockdown of heparanase can efficiently decrease the invasiveness, metastasis and angiogenesis of human gastric cancer cells. In contrast, stable knockdown of heparanase does not affect the cell proliferation. PMID: 19916174 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

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G-CSF in Peg-IFN induced neutropenia in liver transplanted patients with HCV recurrence.

World Journal of Gastroenterology : WJG — Thu, 19 Nov 2009 04:12:27 +0100

CONCLUSION: G-CSF administration is effective in the case of Peg-IFN induced neutropenia increasing neutrophil count, prolonging treatment and leading to sustained virological response (SVR) rates comparable to non-neutropenic patients. It prevents the occurrence of de novo autoimmune hepatitis. PMID: 19916175 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

Reasons of PEG failure to eliminate gastroesophageal reflux in mechanically ventilated patients.

World Journal of Gastroenterology : WJG — Thu, 19 Nov 2009 04:12:25 +0100

CONCLUSION: Endoscopic grading of GEFV and the presence of severe reflux esophagitis are predisposing factors for failure of PEG to reduce GER in mechanically ventilated patients. PMID: 19916176 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

Manometric findings in patients with isolated distal gastroesophageal reflux.

World Journal of Gastroenterology : WJG — Thu, 19 Nov 2009 04:12:22 +0100

CONCLUSION: Patients with erosive and non-erosive disease present with similar manometric abnormalities. The only striking difference is the observation of very low EBCA exclusively in patients with erosive disease. PMID: 19916177 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

Association between Helicobacter pylori seropositivity and digestive tract cancers.

World Journal of Gastroenterology : WJG — Thu, 19 Nov 2009 04:12:19 +0100

CONCLUSION: Our findings support the finding that H pylori seropositivity is inversely associated with esophageal SCC risk, but increases the risk of gastric cardia adenocarcinoma. PMID: 19916178 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

Etiologic factors of gastric cardiac adenocarcinoma among men in Taiwan.

World Journal of Gastroenterology : WJG — Thu, 19 Nov 2009 04:12:16 +0100

CONCLUSION: Working or exercising after meals and H pylori infection increase the risk of GCA, but higher intakes of rice, fresh vegetables and fruits reduce the risk. PMID: 19916179 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

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Efficacy of surgical resection in management of isolated extrahepatic metastases of hepatocellular carcinoma.

World Journal of Gastroenterology : WJG — Thu, 19 Nov 2009 04:12:14 +0100

CONCLUSION: SR can provide survival benefits for patients with 1 or 2 isolated extrahepatic metastases and who concurrently exhibit good hepatic functional reserve and general performance status as well as successful treatment of intrahepatic HCC. PMID: 19916180 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

Small invasive ductal carcinoma of the pancreas distinct from branch duct intraductal papillary mucinous neoplasm.

World Journal of Gastroenterology : WJG — Thu, 19 Nov 2009 04:12:11 +0100

This report describes a case of small adenocarcinoma of the pancreas distinct from branch duct intraductal papillary mucinous neoplasm (IPMN) in which investigation by EUS took place every 6 mo and diagnosis was made accurately by additional CEH-EUS during the follow-up of the branch duct IPMN. A 68-year-old female was admitted to our hospital because of a branch duct IPMN in the pancreatic body. She had been followed-up by EUS every 6 mo. However, after 2 years EUS demonstrated a low echoic area distinct from the branch duct IPMN which was vaguely discernible by EUS, and accurate sizing and differential diagnosis were considered difficult on the EUS imaging. CH-EUS with Sonazoid revealed a hypovascular tumor and we suspected small pancreatic carcinoma. The histopathological diagnosis was ...

Spontaneous liver rupture in a patient with peliosis hepatis: a case report.

World Journal of Gastroenterology : WJG — Thu, 19 Nov 2009 04:12:08 +0100

Authors: Choi SK, Jin JS, Cho SG, Choi SJ, Kim CS, Choe YM, Lee KY Peliosis hepatis is a rare pathological entity and may cause fatal hepatic hemorrhage and liver failure. Here, we present a young male patient with aplastic anemia, who had received long-term treatment with oxymetholone. The patient suffered from sudden onset of intra-abdominal hemorrhage with profuse hemoperitoneum. The patient was treated successfully with a right hemihepatectomy and is in good health after 13 postoperative months. We suggest that peliosis hepatis be considered in patients with hepatic parenchymal hematoma, especially in patients under prolonged synthetic anabolic steroid medication. The possibility of a potentially life-threatening complication of massive intra-abdominal bleeding should also be consi...

Hepatitis B markers and vaccination-induced protection rate among Albanian pregnant women in Greece.

World Journal of Gastroenterology : WJG — Thu, 19 Nov 2009 04:12:05 +0100

Authors: Elefsiniotis IS, Vezali E, Brokalaki H, Tsoumakas K Hepatitis B has long been a serious public health problem both in Greece and in Albania. In the February 2009 issue of World Journal of Gastroenterology, Resuli et al presented the interesting epidemiological data concerning hepatitis B virus infection in Albania. The results of this study were discussed and several data from our similar research were provided. PMID: 19916183 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

Endotipsitis-persistent infection of transjugular intrahepatic portosystemic shunt: pathogenesis, clinical features and management

Liver International — Thu, 19 Nov 2009 00:00:00 +0100

Transjugular intrahepatic portosystemic shunt (TIPS) is in widespread use for the decompression of portal pressure. The entity of persistent TIPS infection, also known as 'endotipsitis' is a rare but serious complication of TIPS insertion. The exact definition of 'endotipsitis' is still debated, but involves persistent bacteremia and fever together with either shunt occlusion, or vegetation, or bacteremia in the presence of a patent shunt, when other sources of bacteremia have been ruled out. To date, approximately 40 cases of 'endotipsitis' have been described, with predominance for male and alcoholic hepatitis patients. The clinical course is variable, but fever and chills are a constant feature. Bacteremia, can either occur early (120 days) after stent insertion, with some cases occurri...

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Hepatocarcinoma cells stimulate the growth, migration and expression of pro-angiogenic genes in human hepatic stellate cells

Liver International — Thu, 19 Nov 2009 00:00:00 +0100

This study aimed to investigate the paracrine effects of hepatocarcinoma cells on human HSC using a co-culture system. Huh7 or HepG2 cells, human hepatocarcinoma cell lines, were co-cultured with primary human HSC. Intracellular calcium mobilization, proliferation, migration, expression of pro-angiogenic and fibrogenic genes, smooth muscle [alpha]-actin ([alpha]-SMA) protein expression, inflammatory properties (nuclear factor kappa B activation and interleukin 8 secretion) and intracellular signalling pathways (AKT and ERK) were analysed in HSC. Culture of HSC with Huh7 cells for 24 h stimulated HSC proliferation, migration and expression of pro-angiogenic genes. The migration effect was corroborated with HepG2 cells. The effects of Huh7 cells on cell proliferation and migration were media...

What are 'true normal' liver stiffness values using FibroScan®?: a prospective study in healthy living liver and kidney donors in South Korea

Liver International — Thu, 19 Nov 2009 00:00:00 +0100

To identify the normal range of liver stiffness (LS) values by recruiting healthy living liver and kidney donors in South Korea. Liver stiffness measurement (LSM) was performed in 69 healthy living liver and kidney donors who were admitted for transplantation. None of the subjects suffered from diabetes mellitus, hypertension, hepatitis B virus infection, hepatitis C virus infection, heart dysfunction, liver dysfunction or metabolic syndrome. LSM failure rate was 2.7%. Among 12 liver donors (17.4%) with available liver histology, eight showed normal liver histology and four showed liver steatosis of (Source: Liver International)

Evidence for the insufficient evaluation and undertreatment of chronic hepatitis B infection in a predominantly low-income and immigrant population

Journal of Gastroenterology and Hepatology — Thu, 19 Nov 2009 00:00:00 +0100

Conclusions: After the diagnosis of HBV infection, few patients in our population received laboratory evaluation to determine eligibility for HBV treatment. Furthermore, only a small percentage received HBV treatment. Further research needs to be done to validate these findings in other populations and understand barriers to receiving HBV treatment. (Source: Journal of Gastroenterology and Hepatology)

Radiofrequency ablation therapy for hepatocellular carcinoma in elderly patients

Journal of Gastroenterology and Hepatology — Thu, 19 Nov 2009 00:00:00 +0100

Conclusions: Elderly HCC patients, who have good performance status, should be treated in the same manner and with the same strategy as young HCC patients. (Source: Journal of Gastroenterology and Hepatology)

Naturally occurring K vitamins inhibit pancreatic cancer cell survival through a caspase-dependent pathway

Journal of Gastroenterology and Hepatology — Thu, 19 Nov 2009 00:00:00 +0100

Conclusion: These data show that naturally-occurring, non-toxic K vitamins can inhibit the survival of some pancreatic cancer cell lines. These novel, safe and clinically-utilized agents initiate a caspase-dependent apoptosis via the MAP kinase pathway and could potentially benefit patients with pancreatic cancer either as a single agent or in combination with chemotherapy for treatment, or for prevention of recurrence of pancreas cancer post resection. (Source: Journal of Gastroenterology and Hepatology)

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Gastric metastasis of hepatocellular carcinoma via a possible existing retrograde hematogenous pathway

Journal of Gastroenterology and Hepatology — Thu, 19 Nov 2009 00:00:00 +0100

Conclusions: When cirrhotic patients with portal hypertension have HCC with PVT, a hematogenous pathway can exist for gastric metastasis of tumor thrombi involving hepatofugal flow to the stomach after TAE or EVL apart from the major pathway of direct invasion. (Source: Journal of Gastroenterology and Hepatology)

Asian perspectives in the management of inflammatory bowel disease: Findings from a recent survey

Journal of Gastroenterology and Hepatology — Thu, 19 Nov 2009 00:00:00 +0100

Conclusion: Clinical practice with regards to IBD diagnosis and management varies within Asia.5-ASA is the preferred treatment and maintenance therapy for mild-to-moderate IBD. (Source: Journal of Gastroenterology and Hepatology)

Laparoscopic splenectomy may be a superior supportive intervention for cirrhotic patients with hypersplenism

Journal of Gastroenterology and Hepatology — Thu, 19 Nov 2009 00:00:00 +0100

Conclusion: Laparoscopic splenectomy may be superior to partial splenic embolization as a supportive intervention for cirrhotic patients with hypersplenism. Future prospective, randomized controlled patient studies are required to confirm these findings. (Source: Journal of Gastroenterology and Hepatology)

Factors associated with nutritional status in liver transplant patients who survived the first year after transplantation

Journal of Gastroenterology and Hepatology — Thu, 19 Nov 2009 00:00:00 +0100

Conclusion: No influence on nutritional status was observed for peri- or postoperative factors after 3 or 12 months of follow up. As expected, dietary factors, especially adequate calorie intake, were always associated with nutritional status during all periods analyzed. (Source: Journal of Gastroenterology and Hepatology)

Clinical manifestations and survival of patients with hepatocellular carcinoma and cardiac metastasis

Journal of Gastroenterology and Hepatology — Thu, 19 Nov 2009 00:00:00 +0100

Conclusions: Hepatocellular carcinoma patients with cardiac metastases were in the advanced stages. These patients had limited survival from the diagnosis of cardiac metastases. The most common cause of death was related to HCC per se or the underlying liver disease. Only a few patients expired because of cardiac metastases. (Source: Journal of Gastroenterology and Hepatology)

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Prevalence, human leukocyte antigen typing and strategy for screening among Asian first-degree relatives of children with celiac disease

Journal of Gastroenterology and Hepatology — Thu, 19 Nov 2009 00:00:00 +0100

Conclusions: In this first Asian study on a limited number of families of children with CD, 4.4% of the first-degree relatives had CD. Only 15% of the first-degree relatives were negative for HLA DQ2/DQ8. Initial evaluation with HLA and serology followed by only serial serology in HLA-positive relatives is recommended. (Source: Journal of Gastroenterology and Hepatology)

TLR4 monoclonal antibody blockade suppresses dextran-sulfate-sodium-induced colitis in mice

Journal of Gastroenterology and Hepatology — Thu, 19 Nov 2009 00:00:00 +0100

Conclusion: Blocking TLR4 by TLR4mAb can prevent the development of DSS-induced colitis through the TLR4-P38MAPK-c-jun pathway. (Source: Journal of Gastroenterology and Hepatology)

Endoplasmic reticulum stress involved in the course of lipogenesis in fatty acids-induced hepatic steatosis

Journal of Gastroenterology and Hepatology — Thu, 19 Nov 2009 00:00:00 +0100

Conclusion: Endoplasmic reticulum stress might be involved in lipogenesis in fatty acids-induced hepatic steatosis. Therefore, endoplasmic reticulum stress might serve as a novel target in the pathogenesis and therapy of non- alcoholic fatty liver disease. (Source: Journal of Gastroenterology and Hepatology)

Systematic investigation of gastrointestinal diseases in China (SILC): validation of survey methodology

BMC Gastroenterology — Thu, 19 Nov 2009 00:00:00 +0100

Conclusions: This population-based study has great potential to characterize the relationship between gastrointestinal symptoms and endoscopic findings in China. (Source: BMC Gastroenterology)

The path to Crohn's disease: Is mucosal pathology a secondary event?

Inflammatory Bowel Diseases — Thu, 19 Nov 2009 00:00:00 +0100

Current models of Crohn's disease (CD) invoke an initial disturbance of the epithelial interface between the gut mucosa and intestinal microbiota. This "outside-in" paradigm, mirroring the pathophysiology of acute gastroenteritis, suggests that mucosal damage by luminal bacteria is an early, initiating factor in the etiopathogenesis of disease. However, a number of features of CD argue against a primary mucosal process, including phenotypic studies of CD patients that point to a macrophage defect and genetic studies that predict impaired innate immunity to intracellular bacteria. Intracellular pathogens, such as Listeria, Salmonella, and Mycobacteria, invade via the gastrointestinal tract with minimal or no acute mucosal pathology. These organisms then infect and persist in lymphatic tissu...

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Haemoglobin and non-alcoholic fatty liver disease: further evidence from a population-based study

Gut — Wed, 18 Nov 2009 18:02:44 +0100

(Source: Gut)

Interleukin 2 targeted therapy in inflammatory bowel disease

Gut — Wed, 18 Nov 2009 18:02:44 +0100

(Source: Gut)

Discordant practice and limited histopathological assessment in gastrointestinal neuromuscular disease

Gut — Wed, 18 Nov 2009 18:02:44 +0100

(Source: Gut)

Long-term safety of Infliximab for the treatment of inflammatory bowel disease: does blocking TNF{alpha} reduce colitis-associated colorectal carcinogenesis?

Gut — Wed, 18 Nov 2009 18:02:44 +0100

(Source: Gut)

Artificial and bioartificial liver devices: present and future

Gut — Wed, 18 Nov 2009 18:02:44 +0100

Liver failure is associated with high morbidity and mortality without transplantation. There are two types of device for temporary support: artificial and bioartificial livers. Artificial livers essentially use non-living components to remove the toxins accumulated during liver failure. Bioartificial livers have bioreactors containing hepatocytes to provide both biotransformation and synthetic liver functions. We review here the operating principles, chemical effects, clinical effects and complications of both types, with specific attention paid to bioartificial systems. Several artificial support systems have FDA marketing authorisation or are CE labelled, but the improvement they provide in terms of patient clinical outcome has not yet been fully demonstrated. At present, different bioar...

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Recent advances in autoimmune pancreatitis

Gut — Wed, 18 Nov 2009 18:02:43 +0100

Autoimmune pancreatitis (AIP) is distinct from calcifying and obstructive forms of chronic pancreatitis. Clinically and histologically it has two distinct subsets: (i) lymphoplasmacytic sclerosing pancreatitis or type 1 AIP which appears to be a systemic disease characterised by abundant infiltration of affected organs with immunoglobulin G4 (IgG4)-positive plasma cells and (2) duct-centric or type 2 AIP characterised by granulocyte epithelial lesions in the pancreas without systemic involvement. In AIP a marked lymphoplasmacytic infiltrate that responds dramatically to steroid therapy suggests an autoimmune aetiology. However, the target autoantigen(s) and the effector cells in AIP remain speculative. Despite the consistent elevation in serum IgG4 levels and tissue infiltration with IgG4-...

JournalScan

Gut — Wed, 18 Nov 2009 18:02:43 +0100

(Source: Gut)

A novel technique for selective NF-{kappa}B inhibition in Kupffer cells: contrary effects in fulminant hepatitis and ischaemia-reperfusion

Gut — Wed, 18 Nov 2009 18:02:43 +0100

Conclusions: NF-B inhibiting decoy oligodeoxynucleotide-loaded gelatin nanoparticles is a novel tool to selectively inhibit NF-B activation in Kupffer cells in vivo. Thus, liver injury can be reduced in experimental fulminant hepatitis, but increased at ischaemia–reperfusion. (Source: Gut)

An unusual case of gastric erosions

Gut — Wed, 18 Nov 2009 18:02:43 +0100

(Source: Gut)

Insulin resistance and geographical origin: major predictors of liver fibrosis and response to peginterferon and ribavirin in HCV-4

Gut — Wed, 18 Nov 2009 18:02:43 +0100

Conclusion: Insulin resistance and geographical origin are major predictors of liver fibrosis and response to peginterferon and ribavirin in HCV-4 patients. Insulin resistance is frequently encountered in these patients, and correlated independently with serum HCV-RNA. (Source: Gut)

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Insulin resistance is associated with liver stiffness in HIV/HCV co-infected patients

Gut — Wed, 18 Nov 2009 18:02:42 +0100

Conclusion: IR is associated with LS in patients co-infected with HIV/HCV. (Source: Gut)

A patient with new onset of thoracic pain, dyspnoea and weight loss

Gut — Wed, 18 Nov 2009 18:02:42 +0100

(Source: Gut)

New aspects of an anti-tumour drug: sorafenib efficiently inhibits HCV replication

Gut — Wed, 18 Nov 2009 18:02:42 +0100

Conclusion: Our data demonstrate that the well-characterised anti-tumour drug sorafenib efficiently blocks HCV replication in vitro. This novel effect of sorafenib should be further explored as an antiviral strategy for patients with chronic HCV infection. (Source: Gut)

Involvement of JNK pathway in the promotion of the early stage of colorectal carcinogenesis under high-fat dietary conditions

Gut — Wed, 18 Nov 2009 18:02:41 +0100

Conclusions: Colonic cell proliferation was promoted via the JNK pathway in the presence of a HFD but not in the presence of a ND. This novel mechanism may explain the involvement of the JNK pathway in the effect of dietary fat intake on colon carcinogenesis. (Source: Gut)

Differential regulation of interleukin 17 and interferon {gamma} production in inflammatory bowel disease

Gut — Wed, 18 Nov 2009 18:02:41 +0100

Conclusions: Our findings support a role for IL12, TGFβ and IL21 in modulating IL17/IFN production in IBD. The abundant IL17 in inflamed IBD mucosa may help explain the relative lack of efficacy of anti-IFN antibodies in clinical trials of Crohn’s disease. (Source: Gut)

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Identification of GP2, the major zymogen granule membrane glycoprotein, as the autoantigen of pancreatic antibodies in Crohn's disease

Gut — Wed, 18 Nov 2009 18:02:40 +0100

Conclusion: Anti-GP2 autoantibodies constitute novel Crohn’s disease-specific markers, the quantification of which could significantly improve the serological diagnosis of IBD. The expression of GP2 in human enterocytes suggests an important role for anti-GP2 response in the pathogenesis of Crohn’s disease. (Source: Gut)

Mucosal gene signatures to predict response to infliximab in patients with ulcerative colitis

Gut — Wed, 18 Nov 2009 18:02:40 +0100

Conclusion: Gene array studies of ulcerative colitis mucosal biopsies identified predictive panels of genes for (non-)response to infliximab. Further study of the pathways involved should allow a better understanding of the mechanisms of resistance to infliximab therapy in ulcerative colitis. ClinicalTrials.gov number, NCT00639821. (Source: Gut)

Linoleic acid, a dietary n-6 polyunsaturated fatty acid, and the aetiology of ulcerative colitis: a nested case-control study within a European prospective cohort study

Gut — Wed, 18 Nov 2009 18:02:40 +0100

Conclusions: The data support a role for dietary linoleic acid in the aetiology of ulcerative colitis. An estimated 30% of cases could be attributed to having dietary intakes higher than the lowest quartile of linoleic acid intake. (Source: Gut)

An unusual cause of obscure gastrointestinal bleeding

Gut — Wed, 18 Nov 2009 18:02:40 +0100

(Source: Gut)

Gliadin-primed CD4+CD45RBlowCD25- T cells drive gluten-dependent small intestinal damage after adoptive transfer into lymphopenic mice

Gut — Wed, 18 Nov 2009 18:02:40 +0100

Conclusions: CD4+ T cell immunity to gluten leads to a breach of oral gluten tolerance and small intestinal pathology in lymphopenic mice, similar to human coeliac disease. This model will be useful for the study of coeliac disease pathogenesis, and also for testing novel non-dietary therapies for coeliac disease. (Source: Gut)

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Role of dietary fibres, intestinal hypermotility and leukotrienes in the pathogenesis of NSAID-induced small intestinal ulcers in cats

Gut — Wed, 18 Nov 2009 18:02:40 +0100

Conclusions: Insoluble DF, intestinal hypermotility, leukotrienes and cholinergic pathways are implicated in the pathogenesis of small intestinal ulcers induced by NSAIDs. (Source: Gut)

Association of adiponectin multimers with Barrett's oesophagus

Gut — Wed, 18 Nov 2009 18:02:40 +0100

Conclusions: High levels of LMW adiponectin are associated with a decreased risk of Barrett’s oesophagus among patients with GORD. Further human studies are required to confirm these findings, and in vitro studies are needed to understand if there is a mechanism whereby adiponectin may affect Barrett’s metaplasia. (Source: Gut)

Selective inhibition of NF-{kappa}B in Kupffer cells: good, but not for everything

Gut — Wed, 18 Nov 2009 18:02:40 +0100

(Source: Gut)

HIV/hepatitis C co-infection and hepatic fibrosis: looking beyond HIV-associated immune suppression; the contribution of hepatic steatosis and insulin resistance

Gut — Wed, 18 Nov 2009 18:02:40 +0100

(Source: Gut)

Ulcerative colitis: is it in the diet?

Gut — Wed, 18 Nov 2009 18:02:40 +0100

(Source: Gut)

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Adiponectin and JNK: metabolic/inflammatory pathways affecting gastrointestinal carcinogenesis

Gut — Wed, 18 Nov 2009 18:02:40 +0100

(Source: Gut)

"Too much, too soon"

Gut — Wed, 18 Nov 2009 18:02:40 +0100

(Source: Gut)

Biomarkers in IBS: when will they replace symptoms for diagnosis and management?

Gut — Wed, 18 Nov 2009 18:02:40 +0100

(Source: Gut)

The year in Gut 2009

Gut — Wed, 18 Nov 2009 18:02:40 +0100

(Source: Gut)

Digest

Gut — Wed, 18 Nov 2009 18:02:40 +0100

(Source: Gut)

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Genetic Predictors of Treatment-Induced Viral Clearance in Hepatitis C

Medscape Gastroenterology Headlines — Wed, 18 Nov 2009 16:09:39 +0100

Drs. Dermot McGovern and Gil Melmed comment on a study published in Nature on the ability of an IL-28B polymorphism to predict sustained viral response to hepatitis C treatment. Medscape Genomic Medicine (Source: Medscape Gastroenterology Headlines)

Subject Index

Journal of Hepatology — Wed, 18 Nov 2009 14:19:54 +0100

(Source: Journal of Hepatology)

Author Index

Journal of Hepatology — Wed, 18 Nov 2009 14:19:54 +0100

(Source: Journal of Hepatology)

Volume Contents

Journal of Hepatology — Wed, 18 Nov 2009 14:19:54 +0100

(Source: Journal of Hepatology)

Announcement

Journal of Hepatology — Wed, 18 Nov 2009 14:19:54 +0100

(Source: Journal of Hepatology)

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Goodbye from Milan!

Journal of Hepatology — Wed, 18 Nov 2009 14:19:50 +0100

As the 5-year term of the editorial team in Milan draws to an end, I would like to take the opportunity to briefly illustrate what we perceive as being the achievements of our tenure together with some of the inevitable unmet goals, and above all to acknowledge the merits of all the persons who successfully contributed to keeping and eventually raising the standard of the Journal. (Source: Journal of Hepatology)

Journal of Hepatology — Wed, 18 Nov 2009 14:19:50 +0100

(Source: Journal of Hepatology)

Many Ways One Aim

Journal of Hepatology — Wed, 18 Nov 2009 14:19:50 +0100

(Source: Journal of Hepatology)

The International Liver Congress 2010

Journal of Hepatology — Wed, 18 Nov 2009 14:19:50 +0100

(Source: Journal of Hepatology)

Season’s Greetings and Best Wishes for 2010

Journal of Hepatology — Wed, 18 Nov 2009 14:19:50 +0100

(Source: Journal of Hepatology)

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Editorial Board

Journal of Hepatology — Wed, 18 Nov 2009 14:19:50 +0100

(Source: Journal of Hepatology)

Abdominal investigations put IBD patients at high radiation exposure risk

MedWire News - Gastroenterology — Wed, 18 Nov 2009 14:18:37 +0100

Diagnostic X-rays put patients with inflammatory bowel disease at increased exposure to high cumulative levels of radiation, say researchers who found that patients undergoing repeated abdominal investigations or surgery are particularly at risk. (Source: MedWire News - Gastroenterology)

A review of quality of life instruments used in liver transplantation

Gastroenterology and Liver Diseases Specialist Library - Liver — Wed, 18 Nov 2009 12:59:37 +0100

Published November 2009 Bottom-line conclusion: No available instruments allow for the precise and reliable assessment of the quality of life (QOL) impact of liver transplantation. The development of a QOL instrument specifically for liver transplant recipients will improve QOL assessment in this population leading to a more nuanced understanding of the factors that influence transplant recipients' well-being. (Source: Gastroenterology and Liver Diseases Specialist Library - Liver)

RSS feed moved

Wed, 18 Nov 2009 12:39:29 +0100

This feed is now inactive at the library.nhs.uk address. For those still using it, please update your subscription to http://feeds.feedburner.com/GLDSCupdatesbiliarygall (Source: Gastroenterology and Liver Diseases Specialist Library - Biliary tree and gallbladder)

Colorectal Cancer Screening in Elderly African-American Patients

Digestive Diseases and Sciences — Wed, 18 Nov 2009 09:30:04 +0100

Content Type Journal ArticleCategory CorrespondenceDOI 10.1007/s10620-009-1037-4Authors Shashideep Singhal, Chicago Medical School at Rosalind Franklin University Gastroenterology, Department of Internal Medicine North Chicago IL USASiddharth Mathur, The Brooklyn Hospital Center Gastroenterology Brooklyn NY USAKris Anand, Chicago Medical School at Rosalind Franklin University Gastroenterology North Chicago IL USA Journal Digestive Diseases and SciencesOnline ISSN 1573-2568Print ISSN 0163-2116 (Source: Digestive Diseases and Sciences)

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Mummies Had Heart Disease, Too

MedicineNet Crohn's Disease General — Wed, 18 Nov 2009 07:00:00 +0100

Title: Mummies Had Heart Disease, TooCategory: Health NewsCreated: 11/18/2009 10:43:00 AMLast Editorial Review: 11/18/2009 10:43:50 AM (Source: MedicineNet Crohn's Disease General)

Anorectal symptoms during pregnancy: how important is trimester?

International Journal of Colorectal Disease — Wed, 18 Nov 2009 00:07:41 +0100

Conclusion The frequency of anorectal symptom reporting appears to increase as pregnancy progresses. Further investigation and research is warranted to determine the configuration of services that may be required to treat those affected. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00384-009-0845-5Authors Samit N. Unadkat, Imperial College Department of Biosurgery and Surgical Technology, Faculty of Medicine London UKDaniel R. Leff, Imperial College Department of Biosurgery and Surgical Technology, Faculty of Medicine London UKTiong-Ghee Teoh, Department of Obstetrics and Gynaecology, St. Mary’s Hospital London UKRaj Rai, Department of Obstetrics and Gynaecology, St. Mary’s Hospital London UKAra W. Darzi, Imperial College Department of Biosurge...

Influence of NFκB inhibitors on IL-1β-induced chemokine CXCL8 and -10 expression levels in intestinal epithelial cell lines: glucocorticoid ineffectiveness and paradoxical effect of PDTC

International Journal of Colorectal Disease — Wed, 18 Nov 2009 00:07:40 +0100

Conclusion These data explain the frequent unresponsiveness of IBD to glucocorticoid treatment and suggest that alternative NFκB inhibition in IECs might be of use in IBD therapy. Drug development based on measuring anti-NFκB activity might be misleading and should therefore also include studies on relevant gene products. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00384-009-0847-3Authors Yeruva Sunil, University of Goettingen Centre for Internal Medicine, Department of Gastroenterology and Endocrinology Goettingen GermanyGiuliano Ramadori, University of Goettingen Centre for Internal Medicine, Department of Gastroenterology and Endocrinology Goettingen GermanyDirk Raddatz, University of Goettingen Centre for Internal Medicine, Department of Ga...

Letter to the editor on article Subcutaneous lateral internal sphincterotomy (SLIS)—a safe technique for treatment of chronic anal fissure

International Journal of Colorectal Disease — Wed, 18 Nov 2009 00:07:39 +0100

Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00384-009-0842-8Authors Biju Aravind, Princess Royal University Hospital Farnborough Kent England UKTarun Singhal, Princess Royal University Hospital Farnborough Kent England UKHussain Almusawy, Princess Royal University Hospital Farnborough Kent England UKAninda Chandra, Princess Royal University Hospital Farnborough Kent England UKPrakash Sinha, Princess Royal University Hospital Farnborough Kent England UK Journal International Journal of Colorectal DiseaseOnline ISSN 1432-1262Print ISSN 0179-1958 (Source: International Journal of Colorectal Disease)

Expression of HMG1 and metastasis of colorectal cancer

International Journal of Colorectal Disease — Wed, 18 Nov 2009 00:07:39 +0100

Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00384-009-0844-6Authors Viroj Wiwanitkit, Wiwanitkit House, Bangkhae Bangkok Thailand 10160 Journal International Journal of Colorectal DiseaseOnline ISSN 1432-1262Print ISSN 0179-1958 (Source: International Journal of Colorectal Disease)

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Multimodal preoperative evaluation system in surgical decision making for rectal cancer: a randomized controlled trial

International Journal of Colorectal Disease — Wed, 18 Nov 2009 00:07:39 +0100

Conclusion MPE is an effective strategy in preoperative staging and more accurate than other available strategies in surgical decision making for rectal cancer. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00384-009-0839-3Authors Xiaodong Wang, Sichuan University Anal-Colorectal Surgery, West China Hospital 37, Guo Xue Xiang Chengdu China 610041Donghao Lv, Sichuan University West China School of Medicine Chengdu ChinaHuan Song, Sichuan University West China School of Medicine Chengdu ChinaLei Deng, Sichuan University West China School of Medicine Chengdu ChinaQiang Gao, Sichuan University West China School of Medicine Chengdu ChinaJunhua Wu, West China Hospital Radiology Chengdu ChinaYingyu Shi, West China Hospital Sonography Chengdu ChinaLi Li, Si...

Outcome of endoscopic submucosal dissection for colorectal tumors in elderly people

International Journal of Colorectal Disease — Wed, 18 Nov 2009 00:07:35 +0100

Conclusions ESD for colorectal tumors resulted in favorable rates of en bloc resection in elderly people. Perforation occurred in elderly people, but these patients were cured with conservative treatment. ESD is a safe and minimally invasive treatment for elderly people with colorectal tumors. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00384-009-0841-9Authors Naohisa Yoshida, Kyoto Prefectural University of Medicine Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku Kyoto 602-8566 JapanYuji Naito, Kyoto Prefectural University of Medicine Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science 465 Kajii-cho, Kawaramachi-Hir...

Laparoscopic correction of enterocele associated to stapled transanal rectal resection for obstructed defecation syndrome

International Journal of Colorectal Disease — Wed, 18 Nov 2009 00:07:34 +0100

Conclusion The combination of STARR and laparoscopy provides a safe and effective method to treat ODS caused by rectal internal prolapse and/or rectocele combined with enterocele. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00384-009-0840-xAuthors Alfonso Carriero, Pelvic Floor Center Montecchio Emilia ItalyMarcello Picchio, Civil Hospital “A. Fiorini” Department of Surgery Via Firenze s.n.c 04019 Terracina ItalyJacopo Martellucci, Pelvic Floor Center Montecchio Emilia ItalyPasquale Talento, Pelvic Floor Center Montecchio Emilia ItalyDomenico Palimento, Civil Hospital “S. Paolo” Department of Surgery Via Terracina 219 80100 Naples ItalyErasmo Spaziani, University of Rome “La Sapienza”- Polo Pontino Department of Surgery Via Firenze, s....

Lipopolysaccharide exposure is linked to activation of the acute phase response and growth failure in pediatric Crohn's disease and murine colitis

Inflammatory Bowel Diseases — Wed, 18 Nov 2009 00:00:00 +0100

Systemic exposure to lipopolysaccharide (LPS) has been linked to clinical disease activity in adults with inflammatory bowel disease (IBD). We hypothesized that markers of LPS exposure and the acute phase response (APR) would be increased in pediatric IBD patients with growth failure, and that LPS signaling would be required for induction of the APR in murine colitis.Serum markers of LPS exposure, endotoxin core IgA antibody (EndoCAb), and the APR, LPS binding protein (LBP) were quantified in pediatric IBD patients and controls. LBP and cytokine production were determined after administration of trinitrobenzene sulfonic acid (TNBS) enemas to mice with genetic deletion of Toll-Like receptor 4 (TLR4), and wildtype (WT) controls.Serum EndoCAb and LBP were significantly elevated in patients wi...

Impact of prior irregular infliximab dosing on performance of long-term infliximab maintenance therapy in Crohn's disease

Inflammatory Bowel Diseases — Wed, 18 Nov 2009 00:00:00 +0100

We examined differences in need for medical and surgical hospitalizations as well as associated healthcare costs between the 2 groups.In all, 104 CD patients met criteria for 3-year maintenance infliximab treatment (SM n = 64; PI n = 40). The rates of CD-related surgeries (60.9% and 55.0%, P = not significant [N.S.]) and medical hospitalizations (35.9% and 37.5%, P = N.S.) prior to infliximab initiation was similar between the 2 groups. However, the rate of medical (26.5% versus 47.5%, P = 0.035) and surgical hospitalizations (21.8% versus 48.7%, P = 0.009) were significantly lower in the SM compared to the PI group. During the third year of treatment the excess costs per patient for the PI group compared to the SM group amounted to $11,464 in spite of both cohorts being on SM therapy.Pati...

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Methotrexate for maintenance of remission in chronic active Crohn's disease: Long-term single-center experience and meta-analysis of observational studies

Inflammatory Bowel Diseases — Wed, 18 Nov 2009 00:00:00 +0100

According to current guidelines methotrexate (MTX) should be considered as a second-line immunomodulator in patients with chronic active Crohn's disease (CD) if purine analogs are not tolerated or there is a lack of efficacy. However, its therapeutic role remains controversial to the present day.Medical records of all eligible patients treated in the outpatient clinic of the Johann Wolfgang Goethe-University Hospital between December 2000 and January 2009 were reviewed.Sixty-three patients were identified. The mean duration of treatment was 100 weeks (range, 2-364 weeks) with a mean cumulative dose of MTX of 2130 mg (range, 40-9005 mg). In 50 (79%) patients started on MTX clinical remission could be achieved within 3 months of treatment. The cumulative probability of these patients to main...

Targeting TGF-[beta]1 by employing a vaccine ameliorates fibrosis in a mouse model of chronic colitis

Inflammatory Bowel Diseases — Wed, 18 Nov 2009 00:00:00 +0100

Intestinal fibrosis and stricture formation are major complications of inflammatory bowel disease (IBD), for which there are currently few effective treatments. We sought to investigate whether targeting transforming growth factor-beta1 (TGF-[beta]1), a key profibrotic mediator, with a peptide-based virus-like particle vaccine would be effective in suppressing intestinal fibrosis by using a mouse model of 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced chronic colitis.The vaccine was prepared by inserting a peptide derived from mouse TGF-[beta]1 into a carrier hepatitis B core antigen using gene recombination methods. Chronic colitis was induced in BALB/c mice by 8 weekly TNBS administrations. Mice were subcutaneously injected with vaccine, carrier, or phosphate-buffered saline (PBS) in...

Magnetic resonance follow-through imaging for evaluation of disease activity in ileal Crohn's disease: An observational, retrospective cohort study

Inflammatory Bowel Diseases — Wed, 18 Nov 2009 00:00:00 +0100

Magnetic resonance follow-through (MRFT) is a new cross-sectional imaging modality with the potential to accurately stage ileal Crohn's disease (CD), while avoiding ionizing radiation and the discomfort associated with enteroclysis. We aimed to assess the reliability of this technique in assessing the extent and activity of ileal CD, and to assess its influence on subsequent management.Out of a total of 342 patients undergoing MRFT between 2004 and 2008, 221 were performed in 191 patients with confirmed CD. Case notes were reviewed in detail with documentation of all investigations pre- and post-MRFT. Agreement between inflammatory markers, histopathology, and MRFT findings was determined.Overall, 116/221 (52.5%) of MRFTs showed active ileal CD, and 76/221 (34.4%) quiescent CD, while 29/22...

Subepithelial dendritic B cells in orofacial granulomatosis

Inflammatory Bowel Diseases — Wed, 18 Nov 2009 00:00:00 +0100

We describe large, active, dendritic B cells in oral mucosa that were not associated with any organized lymphoid tissues in the local subepithelial microenvironment. They express activation induced cytidine deaminase, which is essential for immunoglobulin gene diversification by somatic hypermutation and class switch recombination. IgE is also expressed by these B cells. They do not align with any other previously described B-cell subset in secondary lymphoid tissues in terms of morphology, proliferative activity, or phenotype.These subepithelial dendritic B cells may contribute to the immune responsiveness of the oral mucosa, including IgE-mediated allergic responses. In patients with OFG, further understanding of the role these cells play in oral immunity may lead to novel therapeutic po...

Ulcerative colitis in northern Portugal and Galicia in Spain

Inflammatory Bowel Diseases — Wed, 18 Nov 2009 00:00:00 +0100

Clinical and therapeutic patterns of ulcerative colitis (UC) are variable in different world regions. The purpose of this study was to examine two close independent southern European UC populations from 2 bordering countries and observe how demographic and clinical characteristics of patients can influence the severity of UC.A cross-sectional study was conducted during a 15-month period (September 2005 to December 2006) based on data of 2 Web registries of UC patients. Patients were stratified according to the Montreal Classification and disease severity was defined by the type of treatment taken.A total of 1549 UC patients were included, 1008 (65%) from northern Portugal and 541 (35%) from Galicia (northwest Spain). A female predominance (57%) was observed in Portuguese patients (P < 0.00...

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A prospective, randomized, double-blind, placebo-controlled parallel-group dual site trial to evaluate the effects of a Bacillus coagulans-based product on functional intestinal gas symptom

BMC Gastroenterology — Wed, 18 Nov 2009 00:00:00 +0100

Conclusions: In conclusion, the Bacillus coagulans-based product was effective in improving the quality of life and reducing gastrointestinal symptoms in adults with post prandial intestinal gas-related symptoms and no GI diagnoses.Trial Registration:ClinicalTrials.gov Identifier: NCT00881322 (Source: BMC Gastroenterology)

Fatigue measurements in patients with primary biliary cirrhosis and the risk of mortality during follow-up

Liver International — Wed, 18 Nov 2009 00:00:00 +0100

Fatigue was recently suggested to predict an increased risk of mortality in a primary biliary cirrhosis (PBC) cohort during follow-up. To analyse the impact of fatigue on prognosis in PBC. Patients with PBC who had earlier completed the fatigue impact scale (FIS) were identified. Prognosis in terms of death and liver transplantation (Tx) was determined. FIS values at baseline were analysed from 208 patients (192 females; median age 59 years (interquartile range 51[ndash]67), median follow-up of 5 years. Overall, 181 patients were alive at follow-up, 22 (12%) died and five (2.4%) underwent transplantation. FIS at baseline was 28 (12[ndash]47) and FIS at follow-up was 25 (8[ndash]64) (P (Source: Liver International)

Effects of esomeprazole treatment for gastroesophageal reflux disease on quality of life in 12- to 17-year-old adolescents: an international health outcomes study

BMC Gastroenterology — Wed, 18 Nov 2009 00:00:00 +0100

Conclusion: GERD had a negative effect on QOL in adolescents. After esomeprazole treatment, statistically and clinically significant improvements occurred in all domains of the QOLRAD for these adolescents.Trial Registration: D9614C00098; ClinicalTrials.gov Identifier NCT00241501 (Source: BMC Gastroenterology)

Predictors of a better outcome of pneumatic dilatation in patients with primary achalasia

Journal of Gastroenterology — Tue, 17 Nov 2009 23:58:21 +0100

Conclusions PD is a safe and effective treatment for achalasia, particularly in older patients who experience a better outcome than younger patients. Content Type Journal ArticleCategory Original Article—Alimentary TractDOI 10.1007/s00535-009-0145-4Authors Yuriko Tanaka, Nippon Medical School Division of Gastroenterology, Department of Medicine Sendagi 1-1-5, Bunkyo-ku Tokyo 113-8603 JapanKatsuhiko Iwakiri, Nippon Medical School Division of Gastroenterology, Department of Medicine Sendagi 1-1-5, Bunkyo-ku Tokyo 113-8603 JapanNoriyuki Kawami, Nippon Medical School Division of Gastroenterology, Department of Medicine Sendagi 1-1-5, Bunkyo-ku Tokyo 113-8603 JapanHirohito Sano, Nippon Medical School Division of Gastroenterology, Department of Medicine Sendagi 1-1-5, Bunk...

Treatment of Chronic Hepatitis C in a Patient Affected by Systemic Sclerosis

Gastroenterology Research and Practice — Tue, 17 Nov 2009 14:15:49 +0100

The currently recommended treatment for patients infected with hepatitis C virus (HCV) is pegilated interferon α (IFN α) plus ribavirin. Despite the numerous benefits of this therapy, there is an increasing concern regarding his tolerance. Among the most common side effects, interferon may trigger the onset or exacerbation of autoimmune diseases. When chronic hepatitis C coexists with an autoimmune disorder, it is not clear whether using interferon is better than avoiding it. We evaluated the disease state of a 55-year old female affected by sistemic sclerosis (SSc), during and after therapy with IFNα pegilated plus ribavirin for chronic HCV infection. We were worried about the potential worsening of the autoimmune disease during the therapy, but we were confident t...

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A Prospective Comparison of EUS-Guided FNA Using 25-Gauge and 22-Gauge Needles

Gastroenterology Research and Practice — Tue, 17 Nov 2009 14:15:49 +0100

Conclusion. The 22-gauge and 25-gauge needles have similar overall diagnostic yield. The 25-gauge needle appeared superior in the subset of patients with hard lesions and pancreatic masses. (Source: Gastroenterology Research and Practice)

What Is Dysentery? What Causes Dysentery?

GastroIntestinal News From Medical News Today — Tue, 17 Nov 2009 12:00:00 +0100

Dysentery is an infection of the intestines. This inflammatory disorder causes stomach cramps and diarrhea. According to Medilexicon's medical dictionary, Dysentery is: "A disease marked by frequent watery stools, often with blood and mucus, and characterized clinically by pain, tenesmus, fever, and dehydration". In many cases there are only mild symptoms, such as diarrhea and nausea. (Source: GastroIntestinal News From Medical News Today)

Moderate-Fat Diet May Be Better at Reducing Heart Risks

MedicineNet Crohn's Disease General — Tue, 17 Nov 2009 07:00:00 +0100

Title: Moderate-Fat Diet May Be Better at Reducing Heart RisksCategory: Health NewsCreated: 11/16/2009 4:10:00 PMLast Editorial Review: 11/17/2009 (Source: MedicineNet Crohn's Disease General)

Certain Reflux Drugs Tied to Higher Post-Angioplasty Death Rate

MedicineNet Crohn's Disease General — Tue, 17 Nov 2009 07:00:00 +0100

Title: Certain Reflux Drugs Tied to Higher Post-Angioplasty Death RateCategory: Health NewsCreated: 11/16/2009 12:10:00 PMLast Editorial Review: 11/17/2009 (Source: MedicineNet Crohn's Disease General)

Randomized, double-blind, placebo-controlled trial of the oral interleukin-12/23 inhibitor apilimod mesylate for treatment of active Crohn's disease

Inflammatory Bowel Diseases — Tue, 17 Nov 2009 00:00:00 +0100

Interleukin-12 (IL-12) and interleukin-23 (IL-23) are inflammatory cytokines linked to the Th-1 and Th-17 phenotypes associated with Crohn's disease (CD). We investigated the activity and safety of apilimod mesylate (formerly STA-5326), an oral IL-12 and IL-23 inhibitor, in patients with active CD.We performed a multicenter, Phase 2, randomized, double-blinded, placebo-controlled study to evaluate the efficacy of apilimod mesylate in treating 220 adult patients with moderate-to-severe CD (Crohn's Disease Activity Index [CDAI] score 220-450). Patients were stratified according to C-reactive protein (CRP) levels and corticosteroid use and were randomly assigned to receive placebo or apilimod mesylate 50 mg daily or 100 mg daily. The study was divided into an induction phase (43 days) and a m...

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Pioglitazone improves virological response to peginterferon α-2b/ribavirin combination therapy in hepatitis C genotype 4 patients with insulin resistance

Liver International — Tue, 17 Nov 2009 00:00:00 +0100

Insulin resistance (IR) affects sustained virological response (SVR). The use of insulin-sensitizing agents has been proposed to improve therapy outcome. The safety and efficacy of pioglitazone on insulin sensitivity and SVR in treatment-naïve patients with chronic hepatitis C (CHC) genotype 4 with IR receiving standard antiviral therapy were evaluated in a randomized-controlled study. Ninety-seven previously untreated patients with CHC and IR [homeostasis model assessment (HOMA>2)] were randomly assigned into two arms; (arm A; n=48) were given pioglitazone 30 mg/day combined with peginterferon (Peg-IFN)-[alpha]-2b/ribavirin (RBV) for 48 weeks, and (arm B; n=49) were given standard of care (Peg-IFN-[alpha]-2b/RBV for 48 weeks); HOMA index and hepatitis C virus RNA (HCV RNA) levels were me...

Ki67 and p53 overexpression predict neoplastic progression in BE

MedWire News - Gastroenterology — Mon, 16 Nov 2009 14:16:56 +0100

Researchers have found that overexpression of Ki67 and particularly p53, either alone or in conjunction with other biomarkers, could help predict neoplastic progression in patients with Barrett’s esophagus. (Source: MedWire News - Gastroenterology)

Hepatitis C Screening Of Mothers Using Methadone And Their Babies Is Inadequate, Australia

Liver Disease / Hepatitis News From Medical News Today — Mon, 16 Nov 2009 11:00:00 +0100

Screening for Hepatitis C virus (HCV) infection among pregnant women on methadone maintenance treatment and their infants is inadequate, according to the authors of a study published in the Medical Journal of Australia. Dr Ralph Nanan, Professor of Paediatrics at the University of Sydney, and his co-authors undertook a retrospective review of medical records from two major hospitals in Sydney and a hospital in rural NSW. (Source: Liver Disease / Hepatitis News From Medical News Today)

Largest Gene Study In Childhood IBD Finds 5 New Genes

Irritable-Bowel Syndrome News From Medical News Today — Mon, 16 Nov 2009 10:00:00 +0100

In the largest, most comprehensive genetic analysis of childhood-onset inflammatory bowel disease (IBD), an international research team has identified five new gene regions, including one involved in a biological pathway that helps drive the painful inflammation of the digestive tract that characterizes the disease. A research team led by Hakon Hakonarson, M.D., Ph.D. (Source: Irritable-Bowel Syndrome News From Medical News Today)

Child Food Allergies on the Rise in U.S.

MedicineNet Crohn's Disease General — Mon, 16 Nov 2009 07:00:00 +0100

Title: Child Food Allergies on the Rise in U.S.Category: Health NewsCreated: 11/16/2009 8:10:00 AMLast Editorial Review: 11/16/2009 (Source: MedicineNet Crohn's Disease General)

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FDA OKs Menstrual Drug Lysteda

MedicineNet Crohn's Disease General — Mon, 16 Nov 2009 07:00:00 +0100

Title: FDA OKs Menstrual Drug LystedaCategory: Health NewsCreated: 11/16/2009 11:45:00 AMLast Editorial Review: 11/16/2009 11:45:22 AM (Source: MedicineNet Crohn's Disease General)

Validation of the Spanish version of a questionnaire to measure quality of care through the eyes of patients with inflammatory bowel disease (QUOTE-IBD)

Inflammatory Bowel Diseases — Mon, 16 Nov 2009 00:00:00 +0100

The objective was to translate the QUOTE-IBD into Spanish and to determine its validity in patients with IBD.This is a prospective study in 2 phases: first, translation and validation of the Spanish QUOTE-IBD. Translation was based on the validated QUOTE-IBD. Second, once the complete translation was finished, comprehension of the items was assessed with a specific questionnaire in a reduced number of patients. Criterion validity was assessed with the Pearson's correlation coefficient between scores of the QUOTE-IBD and visual analog scales (VAS). In order to analyze the reproducibility of the Spanish QUOTE-IBD, the questionnaire was completed by stable patients twice, with a span of time of at least 4 weeks.A total of 103 patients (CD: 61, UC: 42) were included in the study. Pearson's cor...

Association among Fas expression in leucocytes, serum Fas and Fas-ligand concentrations and hepatic inflammation and fibrosis in chronic hepatitis C

Liver International — Mon, 16 Nov 2009 00:00:00 +0100

Replication of the hepatitis C virus (HCV) in peripheral blood mononuclear cells (PBMC) may impair immune functions and establish persistent infection. The aim of this study was to assess the influence of HCV on PBMC and their susceptibility to apoptosis in relation to liver inflammation and fibrosis. Eighty-one patients with chronic hepatitis C (CHC) were enrolled in this study. Flow cytometry was used to determine the amount of T cells (CD4+, CD8+), B cells (CD19+), monocytes (CD14+) and natural killer cells (CD16+) in the peripheral blood and the expression of CD95+ (CD95/APO-1) in each subset. Serum concentrations of sFas and sFasL were assessed by the enzyme-linked immunosorbent assay method. An increased expression of Fas was observed in CD4+ and CD8+ cells in CHC. There was a more p...

Clinical Relevance of Transjugular Liver Biopsy in Comparison with Percutaneous and Laparoscopic Liver Biopsy

Gastroenterology Research and Practice — Sun, 15 Nov 2009 14:14:55 +0100

Conclusions. Despite smaller biopsy samples the impact on the clinical decision process was found to be comparable to PLB and mLLB. TJLB represents a helpful tool to determine hepatocellular necrosis rates in patients with acute liver failure. (Source: Gastroenterology Research and Practice)

Behind the headlines - Yoghurt story 'hard to swallow'

Sat, 14 Nov 2009 09:22:43 +0100

Published 13 November 2009A headline in today’s Daily Mail stated: “Yoghurt drinks could beat bugs that pile the weight on.” It said scientists have shown that “bugs that live in our stomachs could be causing us to get fat.” The newspaper said the research could lead to probiotic yoghurts that can combat weight gain. The newspaper’s claim about probiotic yoghurts is misleading. In fact, the study examined the effect of a change in diet on gut flora (micro organisms found in the gut) and weight in mice. The research was well conducted and should help advance investigations into gut flora. However, probiotic drinks such as Yakult, as specifically mentioned in the Daily Mail, did not feature in the study. While it is easy to see how the newspaper made its interpretation, it is too...

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The Use Of Stem Cells In Regenerative Medicine May Be Detrimental For Health

Liver Disease / Hepatitis News From Medical News Today — Sat, 14 Nov 2009 08:00:00 +0100

The use of stem cells in regenerative medicine is not always beneficial for human health, it may even be harmful according to a work done by the University of Granada and University of LeÃ³n. Scientists have demonstrated that transplantation of human mononuclear cells isolated from umbilical cord blood exerted a deleterious effect in rats with liver cirrhosis. (Source: Liver Disease / Hepatitis News From Medical News Today)

New Explanation For Nature's Hardiest Life Form

GastroIntestinal News From Medical News Today — Sat, 14 Nov 2009 08:00:00 +0100

Got food poisoning? The cause might be bacterial spores, en extremely hardy survival form of bacteria, a nightmare for health care and the food industry and an enigma for scientists. Spore-forming bacteria, present almost everywhere in our environment, can also cause serious infectious diseases, such as tetanus, anthrax, and botulism. Now researchers from Lund University and the U.S. (Source: GastroIntestinal News From Medical News Today)

How E. coli Gets Ahead

GastroIntestinal News From Medical News Today — Sat, 14 Nov 2009 08:00:00 +0100

Scientists at the University of York have discovered how certain bacteria such as Escherichia coli have evolved to capture rare sugars from their environment giving them an evolutionary advantage in naturally competitive environments like the human gut. Microbes are well-known for their ability to grow in demanding and nutritionally poor environments, which has allowed them to colonise some of the most remote places on the planet. (Source: GastroIntestinal News From Medical News Today)

Comparison of Postoperative Motility in Hand-Sewn End-to-End Anastomosis and Functional End-to-End Anastomosis: An Experimental Study in Conscious Dogs

Digestive Diseases and Sciences — Sat, 14 Nov 2009 07:01:08 +0100

Conclusions In the present study, there are no significant differences between the EE and FEE with regard to the time of the appearance and the rate of propagation of IMC. These results suggest that the effect of functional end-to-end anastomosis on postoperative motility is not different from that of hand-sewn end-to-end anastomosis. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10620-009-1040-9Authors Yoshitaka Toyomasu, Gunma University Graduate School of Medicine Department of General Surgical Science (Surgery I) 3-39-22 Showa-Machi Maebashi Gunma 371-8511 JapanErito Mochiki, Gunma University Graduate School of Medicine Department of General Surgical Science (Surgery I) 3-39-22 Showa-Machi Maebashi Gunma 371-8511 JapanHiroyuki Ando, Gunma Unive...

Systematic review of neoadjuvant transarterial chemoembolization for resectable hepatocellular carcinoma

Liver International — Sat, 14 Nov 2009 00:00:00 +0100

Resection of hepatocellular carcinoma (HCC) offers the only hope for cure. However, in patients undergoing resection, recurrences, in particular, intrahepatic recurrence are common. The effectiveness of transarterial chemoembolization (TACE) as a neoadjuvant therapy for unresectable HCC was exploited by numerous liver units and employed preoperatively in the setting of resectable HCC with an aim to prevent recurrence and prolong survival. A systematic literature search of databases (Medline and PubMed) to identify published studies of TACE administered preoperatively as a neoadjuvant treatment for resectable HCC was undertaken. A systematic review by tabulation of the results was performed with disease-free survival (DFS) as the primary endpoint. Overall survival (OS), rate of pathological...

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A review of quality of life instruments used in liver transplantation

Gastroenterology and Liver Diseases Specialist Library - Liver — Fri, 13 Nov 2009 22:57:36 +0100

Double-balloon enteroscopy for diagnosis and treatment of small bowel disease

Gastroenterology and Liver Diseases Specialist Library - Small intestine — Fri, 13 Nov 2009 22:53:08 +0100

A record from the CRD Health Techology Assessment Database. Published in July 2009. (Source: Gastroenterology and Liver Diseases Specialist Library - Small intestine)

Behind the headlines - Yoghurt story 'hard to swallow'

Gastroenterology and Liver Diseases Specialist Library - Prevention — Fri, 13 Nov 2009 22:46:45 +0100

A meta-analysis on XRCC1 and XRCC3 polymorphisms and colorectal cancer risk

International Journal of Colorectal Disease — Fri, 13 Nov 2009 18:21:59 +0100

Conclusion Results suggested that 399Q allele might act as a recessive allele in its association with colorectal cancer. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00384-009-0817-9Authors Zheng Jiang, Fudan University Department of Colorectal Surgery, Cancer Hospital 270 Dong An Road Shanghai 200032 ChinaChunxiang Li, Harbin Medical University Laboratory of Medical Genetics 194 XueFu Road Harbin 150081 ChinaYe Xu, Fudan University Department of Colorectal Surgery, Cancer Hospital 270 Dong An Road Shanghai 200032 ChinaSanjun Cai, Fudan University Department of Colorectal Surgery, Cancer Hospital 270 Dong An Road Shanghai 200032 China Journal International Journal of Colorectal DiseaseOnline ISSN 1432-1262Print ISSN 0179-1958 (Source: Interna...

Potential role of chitinase 3-like-1 in inflammation-associated carcinogenic changes of epithelial cells.

World Journal of Gastroenterology : WJG — Fri, 13 Nov 2009 14:46:56 +0100

Authors: Eurich K, Segawa M, Toei-Shimizu S, Mizoguchi E The family of mammalian chitinases includes members both with and without glycohydrolase enzymatic activity against chitin, a polymer of N-acetylglucosamine. Chitin is the structural component of fungi, crustaceans, insects and parasitic nematodes, but is completely absent in mammals. Exposure to antigens containing chitin- or chitin-like structures sometimes induces strong T helper type-I responses in mammals, which may be associated with the induction of mammalian chitinases. Chitinase 3-like-1 (CHI3L1), a member of the mammalian chitinase family, is induced specifically during the course of inflammation in such disorders as inflammatory bowel disease, hepatitis and asthma. In addition, CHI3L1 is expressed and secreted by sever...

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Experimental evidence of obesity as a risk factor for severe acute pancreatitis.

World Journal of Gastroenterology : WJG — Fri, 13 Nov 2009 14:46:53 +0100

Authors: Frossard JL, Lescuyer P, Pastor CM The incidence of acute pancreatitis, an inflammation of the pancreas, is increasing worldwide. Pancreatic injury is mild in 80%-90% of patients who recover without complications. The remaining patients may develop a severe disease with local complications such as acinar cell necrosis, abscess and remote organ injury including lung injury. The early prediction of the severity of the disease is an important goal for physicians in management of patients with acute pancreatitis in order to optimize the therapy and to prevent organ dysfunction and local complications. For that purpose, multiple clinical scale scores have been applied to patients with acute pancreatitis. Recently, a new problem has emerged: the increased severity of the disease in ...

Validation of Fujinon intelligent chromoendoscopy with high definition endoscopes in colonoscopy.

World Journal of Gastroenterology : WJG — Fri, 13 Nov 2009 14:46:50 +0100

CONCLUSION: FICE-filter 4 with magnification improves the image quality of the colonic vascular patterns obtained with WLE. PMID: 19908333 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

Diabetes mellitus as a risk factor for gastrointestinal cancer among American veterans.

World Journal of Gastroenterology : WJG — Fri, 13 Nov 2009 14:46:47 +0100

CONCLUSION: Our study demonstrated that patients with DM have a threefold increased risk for developing pancreatic cancer and a twofold risk for developing biliary cancer. PMID: 19908334 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

Comorbidity negatively influences prognosis in patients with extrahepatic cholangiocarcinoma.

World Journal of Gastroenterology : WJG — Fri, 13 Nov 2009 14:46:45 +0100

CONCLUSION: Tumor resection and comorbidity emerged as significant prognostic variables in extrahepatic cholangiocarcinoma. Comorbidity evaluation instruments should be applied in the clinical management of such patients. PMID: 19908335 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)