MedWorm: Gastroenterology

Nexavar significantly improves overall survival by 47 percent in asia pacific liver cancer study

Liver Disease / Hepatitis News From Medical News Today — Sat, 17 May 2008 08:00:00 +0100

Bayer HealthCare Pharmaceuticals, Inc. and Onyx Pharmaceuticals, Inc. (Nasdaq: ONXX) announced that Nexavar(R) (sorafenib) tablets significantly improved overall survival by 47.3 percent (HR=0.68; p-value=0.014) in patients in the Asia-Pacific region with advanced hepatocellular carcinoma (HCC), or primary liver cancer versus those receiving placebo. Nexavar also significantly improved time to progression in these patients by 74 percent (HR=0.57; P=0.001). (Source: Liver Disease / Hepatitis News From Medical News Today)

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Acute gastrointestinal bleeding.

Best Practice & Research. Clinical Gastroenterology — Fri, 16 May 2008 15:07:34 +0100

Acute gastrointestinal bleeding.

Best Pract Res Clin Gastroenterol. 2008;22(2):207-8

Authors: van Leerdam ME, Tytgat GN

PMID: 18346678 [PubMed - in process]

(Source: Best Practice & Research. Clinical Gastroenterology)

Schering-plough highlights pegintron(tm) and boceprevir hepatitis c data presentations at digestive disease week (ddw) annual meeting

Liver Disease / Hepatitis News From Medical News Today — Fri, 16 May 2008 11:00:00 +0100

Schering-Plough Corporation (NYSE: SGP), a leader in advancing the science and treatment of chronic hepatitis C virus (HCV) infection, announced that data from several clinical studies with PEGINTRON(TM) (peginterferon alfa-2b) and REBETOL(R) (ribavirin, USP) combination therapy, as we (Source: Liver Disease / Hepatitis News From Medical News Today)

Phase ii study of imc-a12 for advanced liver cancer opens for patient enrollment

Liver Disease / Hepatitis News From Medical News Today — Fri, 16 May 2008 10:00:00 +0100

ImClone Systems Incorporated (NASDAQ: IMCL), a global leader in the development and commercialization of novel antibodies to treat cancer, today announced that a Phase II clinical trial of IMC-A12, ImClone's fully human, IgG1 anti-insulin-like growth factor-1 receptor (IGF-1R) monoclonal antibody, in patients with advanced hepatocellular cancer (liver cancer) has opened for patient enrollment. (Source: Liver Disease / Hepatitis News From Medical News Today)

Earlier colon cancer screening?

MedicineNet Liver General — Fri, 16 May 2008 07:00:00 +0100

Title: Earlier Colon Cancer Screening?Category: Health NewsCreated: 5/16/2008Last Editorial Review: 5/16/2008 (Source: MedicineNet Liver General)

Salmonella outbreak linked to dry dog food

MedicineNet Liver General — Fri, 16 May 2008 07:00:00 +0100

Title: Salmonella Outbreak Linked to Dry Dog FoodCategory: Health NewsCreated: 5/16/2008 2:00:00 AMLast Editorial Review: 5/16/2008 (Source: MedicineNet Liver General)

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Percutaneous gastrostomy not linked to poorer survival in elderly with dementia

Medscape Gastroenterology Headlines — Fri, 16 May 2008 02:49:49 +0100

Percutaneous endoscopic gastrostomy (PEG) does not portend a poorer prognosis in elderly patients with dementia compared to those with preserved cognition, Japanese researchers report in the April issue of the American Journal of Gastroenterology. Reuters Health Information (Source: Medscape Gastroenterology Headlines)

A novel preparation to study rat pancreatic spinal and vagal mechanosensitive afferents in vitro

Neurogastroenterology and Motility — Thu, 15 May 2008 18:38:52 +0100

Neurogastroenterology & Motility, Volume 0, Issue 0, Page ???, July 2004. Abstract The management of pancreatic pain is a significant clinical problem so understanding of how sensory signals are generated in pancreatic tissue is fundamental. We aimed to characterize mechanosensitive and chemosensitive properties of pancreatic ... (Source: Neurogastroenterology and Motility)

Targeting vascular endothelial growth factor with the monoclonal antibody bevacizumab inhibits human hepatocellular carcinoma cells growing in an orthotopic mouse model

Liver International — Thu, 15 May 2008 18:36:18 +0100

Liver International, Volume 0, Issue 0, Page ???, March 2004. Abstract Background: Hepatocellular carcinoma (HCC) is one of the leading causes of cancer related death worldwide. Liver resection or transplantation is curative for a subset of patients with localized disease, but treatments for advanced disease are ... (Source: Liver International)

Gastric bypass surgery restores sexual function in morbidly obese men

GastroIntestinal News From Medical News Today — Thu, 15 May 2008 12:00:00 +0100

Losing weight may help resolve erectile dysfunction in obese men, according to research presented at the 103rd Annual Scientific Meeting of the American Urological Association (AUA). Morbid obesity can cause sexual dysfunction independent of other common confounders, including diabetes, hypertension and smoking. In this study from researchers in Boston and Philadelphia, sexual function was normalized in some men who underwent gastric bypass surgery for weight loss. (Source: GastroIntestinal News From Medical News Today)

Pharmasset commences dosing r7128 cohorts 3 and 4 for the treatment of chronic hepatitis c

Liver Disease / Hepatitis News From Medical News Today — Thu, 15 May 2008 11:00:00 +0100

Pharmasset, Inc. (Nasdaq: VRUS) has commenced dosing two additional cohorts of a 4-week Phase 1 study of R7128 in combination with Pegasys(R) (peginterferon alfa-2a) plus Copegus(R) (ribavirin) in both treatment-naive and treatment-experienced patients chronically-infected with hepatitis C virus (HCV) genotypes 1, 2 and 3. R7128, a prodrug of PSI-6130, is a nucleoside analogue polymerase inhibitor of HCV that is being developed through Pharmasset's collaboration with Roche. (Source: Liver Disease / Hepatitis News From Medical News Today)

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Endoscopic ultrasonography-guided interstitial implantation of iodine 125-seeds combined with chemotherapy in the treatment of unresectable pancreatic carcinoma: a prospective pilot study

Endoscopy — Thu, 15 May 2008 10:57:04 +0100

Endoscopy 2008; 40: 314-320DOI: 10.1055/s-2007-995476 Intraoperative and transdermal ultrasonography-mediated brachytherapies have been proved to be effective in postponing the development of abdominal carcinomas. The main purpose of this study was to evaluate the clinical efficacy and safety of endoscopic ultrasonography (EUS)-guided interstitial implantation of radioactive iodine 125 seeds in advanced pancreatic cancer.[...]© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Abstract | Full text (Source: Endoscopy)

Am j physiol gastrointest liver physiol; +28 new citations

Am J Physiol Gastroi... — Thu, 15 May 2008 09:23:54 +0100

28 new PubMed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results:

Am J Physiol Gastrointest Liver Physiol

These PubMed results were generated on 2008/05/15

PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources.

(Source: Am J Physiol Gastroi...)

Correlation of liver biochemistry with liver stiffness in chronic hepatitis b and development of a predictive model for liver fibrosis

Liver International — Thu, 15 May 2008 09:01:29 +0100

Liver International, Volume 0, Issue 0, Page ???, March 2004. Abstract Aim: To correlate liver stiffness with demographical factors and routine liver biochemistry and to assess the predictive value of these as potential markers of fibrosis. Methods: Transient elastography was performed in 1268 chronic hepatitis B ... (Source: Liver International)

Independent and opposite associations of trunk fat and leg fat with liver enzyme levels

Liver International — Thu, 15 May 2008 09:01:16 +0100

Liver International, Volume 0, Issue 0, Page ???, March 2004. Abstract Background: In contrast to trunk fat mass (TFM), which is associated with cardiovascular risk markers, leg fat mass (LFM) displays independent protective effects against atherosclerosis. Little is known about the respective influence of central ... (Source: Liver International)

Origin of stellate cells from submesothelial cells in a developing human liver

Liver International — Thu, 15 May 2008 09:01:03 +0100

Liver International, Volume 0, Issue 0, Page ???, March 2004. Abstract Background: The embryonic origin of liver stellate cells is unknown. Methods: We investigated the development of stellate cells in histological sections of human liver of 7–20 weeks gestation, using neural cell adhesion molecule (N-CAM) to ... (Source: Liver International)

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Serum levels of soluble vascular cell adhesion molecule are related to hyperdynamic circulation in patients with liver cirrhosis

Liver International — Thu, 15 May 2008 09:00:58 +0100

Liver International, Volume 0, Issue 0, Page ???, March 2004. Abstract Background: In patients with liver cirrhosis, serum levels of soluble vascular cell adhesion molecule-1 (sVCAM-1) have been associated with increasing fibrosis and are related to angiogenesis. Aim: To assess the possible correlation between ... (Source: Liver International)

Interlaboratory variability in assessment of the model of end-stage liver disease score

Liver International — Thu, 15 May 2008 09:00:55 +0100

Liver International, Volume 0, Issue 0, Page ???, March 2004. Abstract Background: The model of end-stage liver disease (MELD) score is nowadays widely used to prioritize patients for liver transplantation. Aims: To assess the contribution of the individual components of the MELD score in interlaboratory ... (Source: Liver International)

Effect of steatosis and inflammation on liver fibrosis in chronic hepatitis c

Liver International — Thu, 15 May 2008 09:00:51 +0100

Liver International, Volume 0, Issue 0, Page ???, March 2004. Abstract Background/Aims: The role of liver biopsy has been questioned in the management of patients with hepatitis C viral (HCV) infection. The aims of this study were to determine the impact of clinical parameters and degree of inflammation and ... (Source: Liver International)

Green tea consumption and liver disease: a systematic review

Liver International — Thu, 15 May 2008 09:00:49 +0100

Liver International, Volume 0, Issue 0, Page ???, March 2004. Abstract Objectives: To present the effect of green tea consumption against liver disease. Data sources: Interventional and observational studies both in Western countries and in China and published between the years 1989 and December 2007. Review ... (Source: Liver International)

Role of endogenous opioids in the control of gastric sensorimotor function

Neurogastroenterology and Motility — Thu, 15 May 2008 07:24:11 +0100

Neurogastroenterology & Motility, Volume 0, Issue 0, Page ???, July 2004. Abstract Endogenous opioids have been implicated not only in the process of feeding but also in the control of gastric sensitivity and gastric motor responses, and impairment of antinociceptive opioid pathways has been hypothesized to contribute to the ... (Source: Neurogastroenterology and Motility)

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Small intestinal bacterial overgrowth in irritable bowel syndrome: association with colon motility, bowel symptoms, and psychological distress

Neurogastroenterology and Motility — Thu, 15 May 2008 07:24:04 +0100

Neurogastroenterology & Motility, Volume 0, Issue 0, Page ???, July 2004. Abstract Small intestinal bacterial overgrowth (SIBO) has been implicated in the pathogenesis of irritable bowel syndrome (IBS), although the issue is still under debate. The aim of this study was to determine the prevalence of SIBO in those with IBS and ... (Source: Neurogastroenterology and Motility)

5-hydroxytryptamine selectively activates the vagal nodose c-fibre subtype in the guinea-pig oesophagus

Neurogastroenterology and Motility — Thu, 15 May 2008 07:22:09 +0100

Neurogastroenterology & Motility, Volume 0, Issue 0, Page ???, July 2004. Abstract The afferent neurons innervating the oesophagus originate from two embryonic sources: neurons located in vagal nodose ganglia originate from embryonic placodes and neurons located in vagal jugular and spinal dorsal root ganglia (DRG) originate ... (Source: Neurogastroenterology and Motility)

On the factors regulating the exocrine pancreas, especially its digestive enzymes

Journal of Gastroenterology — Thu, 15 May 2008 06:20:50 +0100

On the factors regulating the exocrine pancreas, especially its digestive enzymes Content Type Journal ArticleCategory Proceedings of the 53rd Annual Meeting : 1967—Nagoya Part IIIDOI 10.1007/BF02827132Authors Yoshiharu Mizuno, Osaka University 2nd Dept. Int. Med. Osaka Journal Journal of GastroenterologyOnline ISSN 1435-5922Print ISSN 0944-1174 Journal Volume Volume 3 Journal Issue Volume 3, Number 2 / June, 1968 (Source: Journal of Gastroenterology)

Immunological studies on gastric diseases

Journal of Gastroenterology — Thu, 15 May 2008 06:20:48 +0100

Immunological studies on gastric diseases Content Type Journal ArticleCategory Original ArticleDOI 10.1007/BF02827130Authors Keiichi Kawai, Kyoto Prefectural University of Medicine Dept. of Medicine JapanToshiyuki Wakabayashi, Kyoto Prefectural University of Medicine Dept. of Medicine JapanShigeyoshi Chikamatsu, Kyoto Prefectural University of Medicine Dept. of Medicine JapanTomio Nagata, Kyoto Prefectural University of Medicine Dept. of Medicine JapanKenji Murakami, Kyoto Prefectural University of Medicine Dept. of Medicine JapanFumio Misaki, Kyoto Prefectural University of Medicine Dept. of Medicine Japan Journal Journal of GastroenterologyOnline ISSN 1435-5922Print ISSN 0944-1174 Journal Volume Volume 3 Journal Issue Volume 3, Number 2 / June, 1968 (Source: Journal of Gastroenterology)

Perforative cases of the gastrointestinal tract

Journal of Gastroenterology — Thu, 15 May 2008 06:20:48 +0100

Perforative cases of the gastrointestinal tract Content Type Journal ArticleCategory Proceedings of the 53rd Annual Meeting : 1967—Nagoya Part IIIDOI 10.1007/BF02827204Authors J. ShikataZ. HondaM. YanaseH. UkishimaM. TakahashiS. SuzukiS. ChibaY. MatuoI. SuzukiA. YamagamiI. OoshiroY. AwaneH. ShimazuH. OtiaiH. KagamiK. ToyamaK. NomuraI. OkazakiN. Sugihara, Bokuto Metropolitan General Hospital Tokyo from The Department of Surgery JapanE. ShiokawaE. Fukatu, Bokuto Metropolitan General Hospital Tokyo The Department of Internal Medicine Japan Journal Journal of GastroenterologyOnline ISSN 1435-5922Print ISSN 0944-1174 Journal Volume Volume 3 Journal Issue Volume 3, Number 2 / June, 1968 (Source: Journal of Gastroenterology)

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Clinical diagnosis of chronic pancreatitis

Journal of Gastroenterology — Thu, 15 May 2008 06:20:48 +0100

Clinical diagnosis of chronic pancreatitis Content Type Journal ArticleCategory Proceedings of the 53rd Annual Meeting : 1967—Nagoya Part IIIDOI 10.1007/BF02827131Authors Kaneo Ishii, Hospital and Institute of National Cancer Center TokyoKozo Nakamura, Hospital and Institute of National Cancer Center Tokyo Journal Journal of GastroenterologyOnline ISSN 1435-5922Print ISSN 0944-1174 Journal Volume Volume 3 Journal Issue Volume 3, Number 2 / June, 1968 (Source: Journal of Gastroenterology)

Clinical evaluation of the pancreas function tests

Journal of Gastroenterology — Thu, 15 May 2008 06:20:45 +0100

Clinical evaluation of the pancreas function tests Content Type Journal ArticleCategory Proceedings of the 53rd Annual Meeting : 1967—Nagoya Part IIIDOI 10.1007/BF02827185Authors T. Higuchi, Tonan Hospital Department of Internal Medicine JapanA. Hirayama, Tonan Hospital Department of Internal Medicine JapanT. Satoh, Tonan Hospital Department of Internal Medicine Japan Journal Journal of GastroenterologyOnline ISSN 1435-5922Print ISSN 0944-1174 Journal Volume Volume 3 Journal Issue Volume 3, Number 2 / June, 1968 (Source: Journal of Gastroenterology)

Sodium retaining substance in liver extract

Journal of Gastroenterology — Thu, 15 May 2008 06:20:45 +0100

Sodium retaining substance in liver extract Content Type Journal ArticleCategory Proceedings of the 53rd Annual Meeting : 1967—Nagoya Part IIIDOI 10.1007/BF02827164Authors H. Maezawa, Tokyo Medical and Dental University Department of Internal Medicine JapanY. Ito, Tokyo Medical and Dental University Department of Internal Medicine JapanH. Matsui, Tokyo Medical and Dental University Department of Internal Medicine JapanK. Ono, Tokyo Medical and Dental University Department of Internal Medicine JapanS. Hosaki, Tokyo Medical and Dental University Department of Internal Medicine JapanK. Ohta, Tokyo Medical and Dental University Department of Internal Medicine Japan Journal Journal of GastroenterologyOnline ISSN 1435-5922Print ISSN 0944-1174 Journal Volume Volume 3 Journal Issue Volume 3, Number 2 / June, 1968 (Source: Journal of Gastroenterology)

Disturbance of acid base balance on hepatic diseases

Journal of Gastroenterology — Thu, 15 May 2008 06:20:44 +0100

Disturbance of acid base balance on hepatic diseases Content Type Journal ArticleCategory Proceedings of the 53rd Annual Meeting : 1967—Nagoya Part IIIDOI 10.1007/BF02827163Authors S. Yamaoka, Keiyu Hospital Department of Internal Medicine JapanT. Yokoyama, Keiyu Hospital Department of Internal Medicine JapanM. Abe, Keiyu Hospital Department of Internal Medicine JapanT. Ohshita, Keiyu Hospital Department of Internal Medicine JapanT. Date, Keiyu Hospital Department of Internal Medicine JapanT. Nose, Keiyu Hospital Department of Internal Medicine JapanY. Watanabe, Keio University, School of Medicine Department of Pathology Japan Journal Journal of GastroenterologyOnline ISSN 1435-5922Print ISSN 0944-1174 Journal Volume Volume 3 Journal Issue Volume 3, Number 2 / June, 1968 (Source: Journal of Gastroenterology)

Serum turbidity test due to addition of alkaloids quinine hydrochloride turbidity test

Journal of Gastroenterology — Thu, 15 May 2008 06:20:44 +0100

Serum turbidity test due to addition of alkaloids quinine hydrochloride turbidity test Content Type Journal ArticleCategory Proceedings of the 53rd Annual Meeting : 1967—Nagoya Part IIIDOI 10.1007/BF02827162Authors S. Hasegawa, Osaka City Shirokita Hospital Osaka JapanT. Matsui, Osaka City Shirokita Hospital Osaka JapanT. Marino, Osaka City Shirokita Hospital Osaka Japan Journal Journal of GastroenterologyOnline ISSN 1435-5922Print ISSN 0944-1174 Journal Volume Volume 3 Journal Issue Volume 3, Number 2 / June, 1968 (Source: Journal of Gastroenterology)

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Study of zinc metabolism in liver damage (the 4th report)

Journal of Gastroenterology — Thu, 15 May 2008 06:20:43 +0100

Study of zinc metabolism in liver damage (The 4th report) Content Type Journal ArticleCategory Proceedings of the 53rd Annual Meeting : 1967—Nagoya Part IIIDOI 10.1007/BF02827160Authors T. Nishi, Osaka University Medical School First Department of Medicine OsakaT. Koizumi, Osaka University Medical School First Department of Medicine Osaka Journal Journal of GastroenterologyOnline ISSN 1435-5922Print ISSN 0944-1174 Journal Volume Volume 3 Journal Issue Volume 3, Number 2 / June, 1968 (Source: Journal of Gastroenterology)

The change of acetone body in the metabolism of liver damage

Journal of Gastroenterology — Thu, 15 May 2008 06:20:43 +0100

The change of acetone body in the metabolism of liver damage Content Type Journal ArticleCategory Proceedings of the 53rd Annual Meeting : 1967—Nagoya Part IIIDOI 10.1007/BF02827161Authors H. Sato, Kagoshima University The Second Department of Internal Medicine Faculty of Medicine JapanS. Hashimoto, Kagoshima University The Second Department of Internal Medicine Faculty of Medicine JapanA. Takahara, Kagoshima University The Second Department of Internal Medicine Faculty of Medicine JapanM. Arimura, Kagoshima University The Second Department of Internal Medicine Faculty of Medicine JapanH. Nojiri, Kagoshima University The Second Department of Internal Medicine Faculty of Medicine Japan Journal Journal of GastroenterologyOnline ISSN 1435-5922Print ISSN 0944-1174 Journal Volume Volume 3 Journal Issue Volume 3, Number 2 / June, 1968 (Source: Journal of Gastroenterology)

The studies on shunt bilirubin (iii)

Journal of Gastroenterology — Thu, 15 May 2008 06:20:42 +0100

The studies on shunt bilirubin (III) Content Type Journal ArticleCategory Proceedings of the 53rd Annual Meeting : 1967—Nagoya Part IIIDOI 10.1007/BF02827158Authors T. Yamamoto, Kyoto University The First Department of Internal Medicine, Faculty of Medicine JapanM. Fujii, Kyoto University The First Department of Internal Medicine, Faculty of Medicine JapanT. Inuki, Kyoto University The First Department of Internal Medicine, Faculty of Medicine JapanM. Iwasaki, Kyoto University The First Department of Internal Medicine, Faculty of Medicine JapanH. Kojima, Kyoto University The First Department of Internal Medicine, Faculty of Medicine JapanA. Miyoshi, Kyoto University The First Department of Internal Medicine, Faculty of Medicine JapanG. Wakisaka, Kyoto University The First Department of Internal Medicine, Faculty of Medicine Japan Journal Journal of GastroenterologyOnline ISSN 1435-5922Print ISSN 0944-1174 Journal Volume Volume 3 Journal Issue Volume 3, Number 2 / June, 1968 (Source: Journal of Gastroenterology)

Serum iron and serum copper in hepatitis and obstructive jaundice patiants

Journal of Gastroenterology — Thu, 15 May 2008 06:20:41 +0100

Serum iron and serum copper in hepatitis and obstructive jaundice patiants Content Type Journal ArticleCategory Proceedings of the 53rd Annual Meeting : 1967—Nagoya Part IIIDOI 10.1007/BF02827159Authors M. Takeuchi, Hino City Hospital JapanM. Sumita, Hino City Hospital JapanR. Ikeda, Hino City Hospital JapanI. Kishi, Hino City Hospital JapanT. Saito, Hino City Hospital Japan Journal Journal of GastroenterologyOnline ISSN 1435-5922Print ISSN 0944-1174 Journal Volume Volume 3 Journal Issue Volume 3, Number 2 / June, 1968 (Source: Journal of Gastroenterology)

The postoperative change of fatty acid constitution in blood in the cases of carcinoma of the esophagus

Journal of Gastroenterology — Thu, 15 May 2008 06:20:39 +0100

The postoperative change of fatty acid constitution in blood in the cases of carcinoma of the esophagus Content Type Journal ArticleCategory Proceedings of the 53rd Annual Meeting : 1967—Nagoya Part IIIDOI 10.1007/BF02827156Authors T. Okamoto, Keio University School of Medicine Department of Surgery JapanY. Nakamura, Keio University School of Medicine Department of Surgery JapanT. Mitomi, Keio University School of Medicine Department of Surgery JapanR. Nakayama, Keio University School of Medicine Department of Surgery JapanT. Kawano, Keio University School of Medicine Department of Surgery JapanT. Hashimoto, Keio University School of Medicine Department of Surgery JapanN. Kono, Keio University School of Medicine Department of Surgery JapanY. Tokura, Keio University School of Medicine Department of Surgery JapanY. Kimura, Keio University School of Medicine Department of Surgery JapanA. Shishikura, Keio University School of Medicine Department of Surgery Japan Journal Journal of GastroenterologyOnline ISSN 1435-5922Print ISSN 0944-1174 Journal Volume Volume 3 Journal Issue Volume 3, Number 2 / June, 1968 (Source: Journal of Gastroenterology)

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Studies on bilirubin phosphate by p32

Journal of Gastroenterology — Thu, 15 May 2008 06:20:39 +0100

Conclusions 1) P32 loaded on the duodenum was excreated into bile after 10–15 minutes (The peak; 6–7 hours after injection). The excreation was continued still after 24 hours. 2) P32 loaded on the duodenum was excreated into bile 1.7% after 8 hours and 4.7% after 24 hours. 3) The radioactivity of P32 on paperchromatogram was detected on the spot corresponding to ester-form bilirubin and could not be observed in other bilirubin fractions. 4) Only the ester-form bilirubin fraction, separated by Kosaka-Hara’s method showed P32-radioactivity. These results suggest that bilirubin phosphate is one part of ester-form bilirubin. Content Type Journal ArticleCategory Proceedings of the 53rd Annual Meeting : 1967—Nagoya Part IIIDOI 10.1007/BF02827157Authors T. Kondo, Okayama University Medical School First Department of Internal Medicine Okayama JapanT. Kawai, Okayama University Medical School First Department of Internal Medicine Okayama JapanM. Takagi, Okayama University Medical School First Department of Internal Medicine Okayama Japan Journal Journal of GastroenterologyOnline ISSN 1435-5922Print ISSN 0944-1174 Journal Volume Volume 3 Journal Issue Volume 3, Number 2 / June, 1968 (Source: Journal of Gastroenterology)

Postcholecystectomy syndrome

Journal of Gastroenterology — Thu, 15 May 2008 06:20:37 +0100

Postcholecystectomy syndrome Content Type Journal ArticleCategory Proceedings of the 53rd Annual Meeting : 1967—Nagoya Part IIIDOI 10.1007/BF02827151Authors Haruo Kameda, University of Tokyo The Second Department of Internal Medicine Japan Journal Journal of GastroenterologyOnline ISSN 1435-5922Print ISSN 0944-1174 Journal Volume Volume 3 Journal Issue Volume 3, Number 2 / June, 1968 (Source: Journal of Gastroenterology)

Effects of antihyperlipemics on the liver lipids of rabbits with experimental-fatty liver

Journal of Gastroenterology — Thu, 15 May 2008 06:20:37 +0100

Conclusions 1. EPL, Ethyllinolate and Ethylnandrol will definitely improve cholesterol-fatty livers of rabbits. 2. CPIB is found to have a restraining power on cholesterol biosynthesis in healthy rabbits but it will not expedite the catabolism on the accumulated cholesterol in livers. 3. It attracts our attention to the fact that metabolism in phospholipids especially phosphatidylethanolamine plays an important role in the cure of fatty liver. Content Type Journal ArticleCategory Proceedings of the 53rd Annual Meeting : 1967—Nagoya Part IIIDOI 10.1007/BF02827155Authors N. Sawa, Social Insurance Central Hospital The Clinic of Internal Medicine TokyoH. Miyamoto, Social Insurance Central Hospital The Clinic of Internal Medicine TokyoY. Kawashima, Social Insurance Central Hospital The Clinic of Internal Medicine TokyoF. Ishimaru, Social Insurance Central Hospital The Clinic of Internal Medicine TokyoT. Tohno, Social Insurance Central Hospital The Clinic of Internal Medicine Tokyo Journal Journal of GastroenterologyOnline ISSN 1435-5922Print ISSN 0944-1174 Journal Volume Volume 3 Journal Issue Volume 3, Number 2 / June, 1968 (Source: Journal of Gastroenterology)

Post cholecystectomic syndrome

Journal of Gastroenterology — Thu, 15 May 2008 06:20:37 +0100

Conclusion Now in conclusion, the author has referred to the problems of postcholecystomic syndromes. In any case, it is essential to make correct diagnosis prior to any treatment in any disease. In my clinic, in 202 cases in period I from 1936 to 1956, the diagnosis was made correctly in 93.6% clinically on admission, and in 645 cases in period II from 1957 to June 1966, in 98.5%. Misdiagnosis was made in 13 cases in period I and in 9 cases in period II, i. e. in total in 22 cases. By the way, for the treatment of cholelithiasis, we surgeons should try to make the correct diagnosis in reference to various clinical symptoms as well as to clinical examinations and for the operation, not to deviate from the correct criteria of the indications and for the operative performance, not to damage the bile ducts or not to leave any gall stone and postoperatively, to pay enough attention to the rehabilitation, thus to endeavour to improve the therapeutic results. Content Type Journal ArticleCategory Proceedings of the 53rd Annual Meeting : 1967—Nagoya Part IIIDOI 10.1007/BF02827154Authors Saburo Matsukura, Nippon Medical School Department of Surgery Tokyo Japan Journal Journal of GastroenterologyOnline ISSN 1435-5922Print ISSN 0944-1174 Journal Volume Volume 3 Journal Issue Volume 3, Number 2 / June, 1968 (Source: Journal of Gastroenterology)

Special comment on postcholecystectomy syndrome

Journal of Gastroenterology — Thu, 15 May 2008 06:20:36 +0100

Conclusion 1) The patients with gall bladder disease, both medical and surgical cases, had a slight disturbance in fat absorption. 2) Of the two, postcholecystectomy group showed lesser disturbance than cholecystopathy patients under medical treatment. 3) It seems that as far as an adequate indication for cholecystectomy exists, patients with gall bladder disease would be rather operated. Content Type Journal ArticleCategory Proceedings of the 53rd Annual Meeting : 1967—Nagoya Part IIIDOI 10.1007/BF02827153Authors Masasuke Masuda, Kyoto Prefectural University of Medicine Professor of Internal Medicine Japan Journal Journal of GastroenterologyOnline ISSN 1435-5922Print ISSN 0944-1174 Journal Volume Volume 3 Journal Issue Volume 3, Number 2 / June, 1968 (Source: Journal of Gastroenterology)

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Special announcement on the blind loop syndrome

Journal of Gastroenterology — Thu, 15 May 2008 06:20:35 +0100

Special announcement on the blind loop syndrome Content Type Journal ArticleCategory Proceedings of the 53rd Annual Meeting : 1967—Nagoya Part IIIDOI 10.1007/BF02827150Authors Tanzo Takayama, Sapporo Medical College Japan Journal Journal of GastroenterologyOnline ISSN 1435-5922Print ISSN 0944-1174 Journal Volume Volume 3 Journal Issue Volume 3, Number 2 / June, 1968 (Source: Journal of Gastroenterology)

Postcholecystectomy syndrome

Journal of Gastroenterology — Thu, 15 May 2008 06:20:35 +0100

Postcholecystectomy syndrome Content Type Journal ArticleCategory Proceedings of the 53rd Annual Meeting : 1967—Nagoya Part IIIDOI 10.1007/BF02827152Authors Yoichi Kasai, Hokkaido University School of Medicine 1st Department of Surgery Sapporo Japan Journal Journal of GastroenterologyOnline ISSN 1435-5922Print ISSN 0944-1174 Journal Volume Volume 3 Journal Issue Volume 3, Number 2 / June, 1968 (Source: Journal of Gastroenterology)

The effect on gastric tone of gastric electrical stimulation with trains of short pulses varies with sites and stimulation conditions

Digestive Diseases and Sciences — Thu, 15 May 2008 06:10:24 +0100

Abstract Background Gastric electrical stimulation (GES) can improve symptoms in patients with gastroparesis and induce weight loss in obese subjects. Aims To evaluate the effect on gastric tone of GES under different conditions at different sites of the stomach. Methods Eleven dogs were implanted with a gastric cannula and two pairs of stimulation electrodes (in the middle of the lesser curvature and of the greater curvature, 10 cm from the pylorus). Gastric tone was assessed with a barostat. GES was applied using: (1) Enterra conditions (14 Hz, 5 mA, 0.3 ms, 0.1 s on, 5 s off); (2) modified Enterra conditions (40 Hz, 5 mA, 0.3 ms, 0.1 s on, 5 s off); and (3) implantable gastric stimulation (IGS) conditions (40 Hz, 5 mA, 0.3 ms, 2 s on, 3 s off). Six sessions were performed randomly with each animal on six separate days. Results (1) At the lesser curvature, GES with modified Enterra conditions significantly elevated gastric volume from 96.9 ± 8.3 ml at baseline to 133.9 ± 11.7 ml (P = 0.015) and a similar effect was observed with IGS (91.3 ± 7.1 ml vs. 186.3 ± 27.1 ml, P = 0.013). GES with Enterra conditions had no such an effect. (2) At the greater curvature, GES with Enterra conditions significantly increased gastric volume from basal 94.1 ± 4.4 ml to 122.1 ± 11.3 ml (P = 0.032); modified Enterra conditions had the opposite effect (96.5 ± 9.0 ml vs. 77.4 ± 11.7 ml, P = 0.025) and no significant effect was observed with IGS conditions. Conclusion The effects of GES on gastric tone vary with the conditions and sites of stimulation. These findings may help to explain the distinct effects of GES therapy in patients with gastroparesis and obesity. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s10620-008-0282-2Authors Yong Lei, Veterans Research Foundation Oklahoma City OK USAJinhong Xing, Veterans Research Foundation Oklahoma City OK USAJiande Chen, Veterans Research Foundation Oklahoma City OK USA Journal Digestive Diseases and SciencesOnline ISSN 1573-2568Print ISSN 0163-2116 (Source: Digestive Diseases and Sciences)

Peptides derived from a soluble molecule of the human leukocyte antigen (hla) class i cause apoptosis in gastric cancer cell lines

Digestive Diseases and Sciences — Thu, 15 May 2008 06:10:24 +0100

Abstract We have reported that the levels of the soluble molecule of the human leukocyte antigen class I (sHLA-I) in patients with advanced gastric cancer were significantly lower than those in patients with cancer in the early stages. However, the effect of sHLA-I on gastric cancer cells has not been elucidated. Using human gastric cancer cell lines, MKN28, MKN45, and MKN74, we evaluated the effects of sHLA-I on cell growth, DNA synthesis, and apoptosis induction. Three types of synthesized peptides derived from HLA-I were also examined for their capacity to induce apoptosis. sHLA-I and a synthesized peptide, nos. 220–232 of the α3 domain of HLA-B7, caused cell growth inhibition by inducing apoptosis in human gastric cancer cells. This peptide also inhibited the in vivo growth of cancer dissemination caused by an intraperitoneal injection of MKN45 into severe combined immunodeficient mice. In conclusion, sHLA-I and the peptides derived from HLA-I cause apoptosis in human gastric cancer cell lines. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s10620-008-0308-9Authors Tatsuo Shimura, Gunma University Graduate School of Medicine Department of General Surgical Science (Surgery I) 3-39-15 Showa-machi, Maebashi Gunma 371-8511 JapanTaketoshi Suehiro, Gunma University Graduate School of Medicine Department of General Surgical Science (Surgery I) 3-39-15 Showa-machi, Maebashi Gunma 371-8511 JapanHideki Suzuki, Gunma University Graduate School of Medicine Department of General Surgical Science (Surgery I) 3-39-15 Showa-machi, Maebashi Gunma 371-8511 JapanYasushi Mochida, Gunma University Graduate School of Medicine Department of General Surgical Science (Surgery I) 3-39-15 Showa-machi, Maebashi Gunma 371-8511 JapanKoji Okada, Gunma University Graduate School of Medicine Department of General Surgical Science (Surgery I) 3-39-15 Showa-machi, Maebashi Gunma 371-8511 JapanErito Mochiki, Gunma University Graduate School of Medicine Department of General Surgical Science (Surgery I) 3-39-15 Showa-machi, Maebashi Gunma 371-8511 JapanHiroyuki Kuwano, Gunma University Graduate School of Medicine Department of General Surgical Science (Surgery I) 3-39-15 Showa-machi, Maebashi Gunma 371-8511 Japan Journal Digestive Diseases and SciencesOnline ISSN 1573-2568Print ISSN 0163-2116 (Source: Digestive Diseases and Sciences)

Hybrid capture ii detection of oncogenic human papillomavirus: a useful tool when evaluating men who have sex with men with atypical squamous cells of undetermined significance on anal cytology

Diseases of the Colon & Rectum — Thu, 15 May 2008 06:02:16 +0100

Abstract Purpose In the cervix and anus, patients with atypical squamous cells of undetermined significance often do not have high-grade squamous intraepithelial lesions. In women with atypical squamous cells of undetermined significance, Hybrid-Capture II testing for oncogenic high-risk human papillomavirus is performed and those without high-risk human papillomavirus often are observed. We endeavored to determine whether Hybrid-Capture II testing would be beneficial in men who have sex with men with atypical squamous cells of undetermined significance. Methods We performed a retrospective chart review of men who have sex with men with atypical squamous cells of undetermined significance who had high-resolution anoscopy and Hybrid-Capture II. Results A total of 290 men were identified (mean age, 42 years), and 212 (73 percent) were HIV-negative. High-grade squamous intraepithelial lesions were found in 50 (17 percent): 23 (10 percent) who were HIV-negative and 27 (35 percent) who were HIV-positive men. High-risk human papillomavirus was found in 138 (48 percent); 91 (43 percent) of HIV-negative and 47 (60 percent) of HIV-positive men. The sensitivity, specificity, positive predictive value, and negative predictive value of atypical cells of undetermined significance cytology combined with Hybrid-Capture II were 84, 60, 30, and 95 percent, respectively. There was no significant difference between all men vs. those who were HIV-positive or HIV-negative except for the positive predictive value. Conclusions Hybrid-Capture II testing for high-risk human papillomavirus in men who have sex with men with atypical cells of undetermined significance and referring only those with high-risk human papillomavirus reduces the number who require high-resolution anoscopy by more than half. Five percent with high-grade squamous intraepithelial lesions would be missed. Content Type Journal ArticleCategory Original ContributionDOI 10.1007/s10350-008-9306-4Authors Stephen E. Goldstone, Department of Surgery Mt. Sinai School of Medicine New York New York USAAdam Z. Kawalek, Department of Internal Medicine New York University School of Medicine New York New York USARobert N. Goldstone, Department of Surgery Mt. Sinai School of Medicine New York New York USAAndrew B. Goldstone, Department of Surgery Mt. Sinai School of Medicine New York New York USA Journal Diseases of the Colon & RectumOnline ISSN 1530-0358Print ISSN 0012-3706 (Source: Diseases of the Colon & Rectum)

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Diseases of the Colon & Rectum — Thu, 15 May 2008 06:02:16 +0100

The Author Replies Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s10350-008-9331-3Authors Fernando de la Portilla, Hospital Juan Ramon Jimenez Colorrectal Surgery Ronda Norte s/n Huelva 21005 Spain Journal Diseases of the Colon & RectumOnline ISSN 1530-0358Print ISSN 0012-3706 (Source: Diseases of the Colon & Rectum)

Transanal endoscopic microsurgery is more effective than traditional transanal excision for resection of rectal masses

Diseases of the Colon & Rectum — Thu, 15 May 2008 06:02:12 +0100

Abstract Purpose Transanal endoscopic microsurgery, developed by Buess in the 1980s, has become increasingly popular in recent years. No large studies have compared the effectiveness of transanal endoscopic microsurgery with traditional transanal excision. Methods Between 1990 and 2005, 171 patients underwent traditional transanal excision (n = 89) or transanal endoscopic microsurgery (n = 82) for rectal neoplasms. Medical records were reviewed to determine type of surgery, resection margins, specimen fragmentation, complications, recurrence, lesion type, stage, and size. Results The groups were similar with respect to age, sex, lesion type, stage, and size. Mean follow-up was 37 months. There was no difference in the complication rate between the groups (transanal endoscopic microsurgery 15 percent vs. traditional transanal excision 17 percent, P = 0.69). Transanal endoscopic microsurgery was more likely to yield clear margins (90 vs. 71 percent, P = 0.001) and a nonfragmented specimen (94 vs. 65 percent, P < 0.001) compared with transanal excision. Recurrence was less frequent after transanal endoscopic microsurgery than after traditional transanal excision (5 vs. 27 percent, P = 0.004). Conclusions Transanal endoscopic microsurgery is the technique of choice for local excision of rectal neoplasms. Content Type Journal ArticleCategory Original ContributionDOI 10.1007/s10350-008-9337-xAuthors Jesse S. Moore, Fletcher Allen Health Care/University of Vermont College of Medicine Department of Surgery Burlington Vermont USAPeter A. Cataldo, Fletcher Allen Health Care/University of Vermont College of Medicine Department of Surgery Burlington Vermont USATurner Osler, Fletcher Allen Health Care/University of Vermont College of Medicine Department of Surgery Burlington Vermont USANeil H. Hyman, Fletcher Allen Health Care/University of Vermont College of Medicine Department of Surgery Burlington Vermont USA Journal Diseases of the Colon & RectumOnline ISSN 1530-0358Print ISSN 0012-3706 (Source: Diseases of the Colon & Rectum)

The oblique rectus abdominal myocutaneous flap for complex pelvic wound reconstruction

Diseases of the Colon & Rectum — Thu, 15 May 2008 06:02:12 +0100

Abstract Purpose The oblique rectus abdominal myocutaneous flap is a seldom used flap design based on perforating vessels exiting the rectus near the umbilicus. Compared to other flaps, the oblique rectus abdominal myocutaneous flap provides increased soft tissue to fill pelvic dead space, with the further advantage of intact skin to close perineal defects. Here we detail the oblique rectus abdominal myocutaneous flap in achieving closure of complex perineal wounds. Methods A review of indications and outcomes in 16 patients undergoing complex pelvic operations requiring reconstruction with this flap was undertaken. Results All patients had been previously treated with pelvic irradiation for cancer. Indications for flap reconstruction included abdominal perineal resection for anal/rectal cancer, pelvic sarcoma/sacral resection/exenteration, small bowel/colonic fistula resection, and total proctocolectomy with vaginal reconstruction. Median follow-up was 17 (range, 1–57) months. Complications included epidermal necrosis at the flap tip (n = 2), delayed perineal wound breakdown (n = 1), one abdominal wound infection, one small abdominal dehiscence, and four pelvic abscesses all managed nonoperatively. A single recurrent fistula required operative resection three months postoperatively. There were no cases of complete flap necrosis, vascular failure or persistently draining perineal sinus, and no mortalities related to the flap reconstruction. Conclusions The treatment of complex pelvic wounds, especially following pelvic radiation, is facilitated by the oblique rectus abdominal myocutaneous flap. This technique provides ample tissue for large pelvic wounds, including skin for perineal defects. Comparing our results to existing literature, the oblique rectus abdominal myocutaneous flap displays a favorable morbidity profile, providing a safe means of delivering well-vascularized tissue to the pelvic cavity and perineal floor. Content Type Journal ArticleCategory Original ContributionDOI 10.1007/s10350-008-9359-4Authors Daniel E. Abbott, Northwestern University, Feinberg School of Medicine Department of Surgery Galter 3rd Floor, 201 E. Huron Chicago Illinois 60611 USAAmy L. Halverson, Northwestern University, Feinberg School of Medicine Department of Surgery Galter 3rd Floor, 201 E. Huron Chicago Illinois 60611 USAJeffrey D. Wayne, Northwestern University, Feinberg School of Medicine Department of Surgery Galter 3rd Floor, 201 E. Huron Chicago Illinois 60611 USAJohn Y. S. Kim, Northwestern University, Feinberg School of Medicine Department of Surgery Galter 3rd Floor, 201 E. Huron Chicago Illinois 60611 USAMark S. Talamonti, Northwestern University, Feinberg School of Medicine Department of Surgery Galter 3rd Floor, 201 E. Huron Chicago Illinois 60611 USAGregory A. Dumanian, Northwestern University, Feinberg School of Medicine Department of Surgery Galter 3rd Floor, 201 E. Huron Chicago Illinois 60611 USA Journal Diseases of the Colon & RectumOnline ISSN 1530-0358Print ISSN 0012-3706 (Source: Diseases of the Colon & Rectum)

An innovative technique for colorectal specimen retrieval: a new era of “natural orifice specimen extraction” (n.o.s.e)

Diseases of the Colon & Rectum — Thu, 15 May 2008 06:02:11 +0100

Abstract Purpose The common incisions for transabdominal specimen retrieval after laparoscopic colorectal surgery are lower quadrant, midline, or transverse suprapubic incision. This study was designed to evaluate a novel method of specimen extraction after totally laparoscopic proctocolectomies. Methods We retrospectively studied seven women patients from 2004 to 2007. The indication for surgery was familial polyposis coexisting with adenocarcinoma of the upper rectum. A totally laparoscopic proctocolectomy with ileal pouch-anal anastomosis was successfully performed for all cases. The entire specimen was extracted via a transvaginal route. Results The mean age of the patients was 49.5 years, and mean body mass index was 25.3 kg/m2. The mean operating time was 222.5 minutes, and average blood loss was 172 ml. The average hospital stay was 25.5 days. Postoperative complications included ileus (n = 1), pouchitis (n = 1), and deep vein thrombosis (n = 1). The vaginal wound had healed completely by the first follow-up. There was no mortality. Conclusions Our technique of transvaginal retrieval effectively prevents wound-related complications by completely eliminating minilaparotomies for specimen retrieval. It could be called “Natural Orifice Specimen Extraction,” or N.O.S.E. We stress the need for innovations in specimen extraction, for which importance is not given by surgeons. Content Type Journal ArticleCategory Original ContributionDOI 10.1007/s10350-008-9316-2Authors Chinnusamy Palanivelu, GEM Hospital and Postgraduate Institute 45-A, Pankaja Mill Road, Ramnathapuram Coimbatore 641045 IndiaMuthukumaran Rangarajan, GEM Hospital and Postgraduate Institute 45-A, Pankaja Mill Road, Ramnathapuram Coimbatore 641045 IndiaPriyadarshan Anand Jategaonkar, GEM Hospital and Postgraduate Institute 45-A, Pankaja Mill Road, Ramnathapuram Coimbatore 641045 IndiaNatesan Vijay Anand, GEM Hospital and Postgraduate Institute 45-A, Pankaja Mill Road, Ramnathapuram Coimbatore 641045 India Journal Diseases of the Colon & RectumOnline ISSN 1530-0358Print ISSN 0012-3706 (Source: Diseases of the Colon & Rectum)