MedWorm: Hematology Top 20

ASCO GU: New Test Gets Positive Results for Prostate CA

MedPage Today Hematology/Oncology — Sun, 07 Mar 2010 13:13:05 +0100

SAN FRANCISCO Another novel urine test appears to improve detection of prostate cancer, particularly of aggressive tumors, researchers reported. (Source: MedPage Today Hematology/Oncology)

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Advances in understanding the pathogenesis of chronic thromboembolic pulmonary hypertension

British Journal of Haematology — Tue, 16 Mar 2010 00:00:00 +0100

Chronic thromboembolic pulmonary hypertension (CTEPH) comprises organizing thrombotic obstructions in the pulmonary arteries. While roughly 40% of CTEPH cases are not preceded by a venous thromboembolic event, 0·1[ndash]5·1% of acute pulmonary thromboemboli evolve into organized obstructions of the pulmonary artery. In patients with predominantly proximal disease, surgical pulmonary endarterectomy provides a potential cure of the disease. For years, the scientific debate of CTEPH was mainly focused around its thromboembolic nature because of striking dissimilarities to classical venous thromboembolism, for example, the lack of risk factors for venous thrombosis, the lack of clinically apparent pulmonary embolism in many patients, the difficulty to reproduce the disease in animal models o...

ASCO GU: Novel Retrovirus Mimics HIV Transmission

MedPage Today Hematology/Oncology — Sat, 06 Mar 2010 23:29:15 +0100

SAN FRANCISCO (MedPage Today) -- A novel retrovirus implicated in prostate cancer appears to be transmitted much the way HIV is, researchers found. (Source: MedPage Today Hematology/Oncology)

In Prostate CA, Sexual Decline After Radiation Has Limit (CME/CE)

MedPage Today Hematology/Oncology — Sat, 30 Jan 2010 13:13:05 +0100

Sexual function declines in the first two years after external beam radiation therapy for prostate cancer but stabilizes thereafter, according to data from a prospective cohort study. (Source: MedPage Today Hematology/Oncology)

Aggressive Prostate Cancer Linked to Trichomonas (CME/CE)

MedPage Today Hematology/Oncology — Wed, 09 Sep 2009 20:00:00 +0100

The sexually transmitted infection Trichomonas vaginalis increases risk of clinically-relevant, aggressive prostate cancer, researchers affirmed. (Source: MedPage Today Hematology/Oncology)

Targeting Chronic Myeloid Leukemia Stem Cells

Current Hematologic Malignancy Reports — Wed, 24 Feb 2010 06:55:53 +0100

Abstract Chronic myeloid leukemia (CML) arises as a consequence of a chromosomal translocation giving rise to the Philadelphia chromosome and Bcr-Abl oncogene. CML is a clonal disease of stem cell origin and an excellent example of a malignancy in which tumor-initiating cells may hold the key to disease eradication. The known molecular basis of CML has enabled the development of Abl-specific tyrosine kinase inhibitors, such as imatinib mesylate. However, the success of tyrosine kinase inhibitors, as rationally designed first-line therapies, has been tempered by problems of disease persistence and resistance. Residual disease has been shown to be enriched within the stem cell compartment and to persist at stable levels for up to 5 years of complete cytogenetic response...

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Peptide vaccination elicits leukemia-associated antigen-specific cytotoxic CD8+ T-cell responses in patients with chronic lymphocytic leukemia

Leukemia — Thu, 11 Mar 2010 00:00:00 +0100

Peptide vaccination elicits leukemia-associated antigen-specific cytotoxic CD8+ T-cell responses in patients with chronic lymphocytic leukemia Leukemia advance online publication, March 11, 2010. doi:10.1038/leu.2010.29 Authors: K Giannopoulos, A Dmoszynska, M Kowal, J Rolinski, E Gostick, D A Price, J Greiner, M Rojewski, S Stilgenbauer, H Döhner & M Schmitt (Source: Leukemia)

Chronic lymphocytic leukemia presenting with symptomatic peritoneal infiltration

Leukemia Research — Tue, 23 Feb 2010 14:33:41 +0100

We report the very rare case of CLL diagnosis in a patient suffering from epigastralgia due to peritoneal infiltration. (Source: Leukemia Research)

Medical Articles 6/2

CML Newswire — Sun, 03 Jun 2007 02:55:18 +0100

Fluoropolymer Based on a Polyaspartamide containing 1,2,4-Oxadiazole Units: A Potential Artificial Oxygen (O(2)) Carrier. Information is temporarily unavailable. Invasive pulmonary aspergillosis with hematological malignancy caused by Aspergillus terreus and in vitro susceptibility of A. terreus isolate to micafungin. Information is temporarily unavailable. A novel treatment strategy targeting Aurora kinases in acute myelogenous leukemia. Information is temporarily unavailable. Farnesyl transferase inhibitor resistance probed by target mutagenesis. (Source: CML Newswire)

Listing Of CML Clinical Trials

CML Newswire Archives: CMLHope.Com — Sat, 03 Jun 2006 06:00:00 +0100

Discussion in Improving Quality of Life in Young Patients Undergoing Stem Cell TransplantConditions: Cancer; Fatigue; Pain; Psychosocial Effects and Treatment142.RecruitingMoxifloxacin Compared With Ciprofloxacin/Amoxicillin in Treating Fever and Neutropenia in Patients With CancerConditions: Adult Solid Tumor; Fever, Sweats, and Hot Flashes; Hematopoietic and Lymphoid Cancer; Infection; Neutropenia143.RecruitingTacrolimus and Mycophenolate Mofetil in Preventing Graft-Versus-Host Disease in Patients Who Have Undergone Donor Stem Cell Transplantation for Hematologic CancerConditions: Childhood Hodgkin's Lymphoma; Childhood Non-Hodgkin's Lymphoma; Graft Versus Host Disease; Hematopoietic and Lymphoid Cancer144.RecruitingCaspofungin Acetate in Treating Aspergillosis in Patients With Hematolog...

Medical Articles 5/2

CML Newswire — Thu, 03 May 2007 16:06:00 +0100

Long-term follow-up of children who underwent hematopoeitic cell transplant (HCT) for AML or ALL at less than 3 years of age. Information is temporarily unavailable. Parapharyngeal abscess by Aspergillus flavus in a neutropenic patient with myelogenous leukaemia. Information is temporarily unavailable. Chronic myelogenous leukemia progenitors display a genetically unstable personality. Information is temporarily unavailable. Fludarabine and busulfan as a myeloablative conditioning regimen for allogeneic stem cell transplantation in high- and standard-risk leukemic patients. (Source: CML Newswire)

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Diabetes insipidus as main presentation of non-Hodgkin's lymphoma with hypophyseal involvement: Two case reports

Leukemia Research — Fri, 01 Jan 2010 00:00:00 +0100

Non-Hodgkin's lymphoma (NHL) presenting with diabetes insipidus (DI) in consequence of hypophyseal lesion is relatively rare. The condition may occur as either primary central nervous system (CNS) lymphoma or systemic lymphoma with meningeal or parenchymal involvement . As the latter, it is more often in intermediate and high grade malignant NHL . Although a few unusual localizations in CNS have been reported, the data about pituitary involvement with DI as first complaint of NHL is very limited. Here, we report on two cases who complained of DI before NHL was diagnosed. Brain MRI showed absence of the normal hyperintense signal at the posterior lobe of the pituitary in both cases, slight enlargement of the pituitary stalk in one patient with Burkitt lymphoma, and an empty sella with defor...

CD38 increases CXCL12-mediated signals and homing of chronic lymphocytic leukemia cells

Leukemia — Thu, 11 Mar 2010 00:00:00 +0100

Authors: T Vaisitti, S Aydin, D Rossi, F Cottino, L Bergui, G D'Arena, L Bonello, A L Horenstein, P Brennan, C Pepper, G Gaidano, F Malavasi & S Deaglio (Source: Leukemia)

Primary non-Hodgkin lymphoma of cervix successfully treated with rituximab: Positron emission tomography images before and after therapy: A case report

Leukemia Research — Tue, 23 Feb 2010 14:33:40 +0100

Primary non-Hodgkin's lymphoma (NHL) of the genital tract is extremely rare (0.5%) and mostly originates from the ovary . The cervix lymphoma is 0.008% of the all cervix tumors and 2% of the all extranodal lymphomas in the females . The most common histological type is diffused large B cell lymphoma (DLBCL) . Primary cervical carcinoma, sarcoma or benign inflammatory conditions are kept in mind in differential diagnosis . Histopathological and immunohistochemical examinations of cervix biopsy specimen are required for definitive diagnosis . In staging, computerized tomography (CT) of the pelvis, abdomen and thorax or position emission tomography (PET–CT) can be used. There is not any established treatment protocol for primary cervix lymphoma (PCL) due to rarity of disease. Radiotherapy (...

MHNCS: IMRT Effective But Toxic for Recurrent H&N Cancer (CME/CE)

MedPage Today Hematology/Oncology — Mon, 01 Mar 2010 13:43:09 +0100

PHOENIX (MedPage Today) -- Patients with recurrent or second primary squamous-cell head and neck cancer achieved durable tumor control with intensity modulated radiation therapy (IMRT) and chemotherapy, a small retrospective clinical review showed, but the improvement came at a toxic price. (Source: MedPage Today Hematology/Oncology)

Primary mantle cell lymphoma of the thyroid

Leukemia Research — Tue, 23 Feb 2010 14:33:39 +0100

Non-Hodgkin's lymphoma (NHL) incidence has rapidly increased since the 1970s. Incidence rates increased proportionally more for extranodal NHL than for nodal NHL . Primary NHL of the thyroid (PNHLT) is an uncommon diagnosis, accounting for 5% of all thyroid malignancies and 2% of primitive extranodal lymphomas, with an incidence of 0.5 per 100,000 population . (Source: Leukemia Research)

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Autoimmune B-cell lymphopenia after successful adoptive therapy with telomerase-specific T lymphocytes

Blood — Thu, 18 Feb 2010 17:01:20 +0100

Telomerase reverse transcriptase (TERT) is a good candidate for cancer immunotherapy because it is overexpressed in 85% of all human tumors and implicated in maintenance of the transformed phenotype. TERT-based cancer vaccines have been shown to be safe, not inducing any immune-related pathology, but their impact on tumor progression is modest. Here we show that adoptive cell therapy with the use of high-avidity T lymphocytes reactive against telomerase can control the growth of different established tumors. Moreover, in transgenic adenocarcinoma mouse prostate mice, which develop prostate cancer, TERT-based adoptive cell therapy halted the progression to more aggressive and poorly differentiated tumors, significantly prolonging mouse survival. We also demonstrated that human tumors, inclu...

Second malignancies in B-cell chronic lymphocytic leukaemia: possible association with human papilloma virus

British Journal of Haematology — Mon, 08 Mar 2010 00:00:00 +0100

This report describes preliminary evidence for the presence of HPV in secondary malignancies, in patients with CLL. (Source: British Journal of Haematology)

Final analysis of the UKLG LY02 trial comparing 6–8 cycles of CHOP with 3 cycles of CHOP followed by a BEAM autograft in patients

British Journal of Haematology — Mon, 01 Mar 2010 00:00:00 +0100

In conclusion, no survival benefit was demonstrated for an early autograft in first response. (Source: British Journal of Haematology)

Abnormal fatty acid distribution of the serum phospholipids of patients with non-Hodgkin lymphoma

Annals of Hematology — Tue, 02 Feb 2010 17:46:52 +0100

Abstract The data about the fatty acid (FA) status of non-Hodgkin lymphoma (NHL) patients are poor. Therefore, the aim of this study was to investigate the FA profile of serum phospholipids in NHL patients related to the aggressiveness and clinical stage of NHL. We analyzed the FA profile of serum phospholipids in 47 newly diagnosed, untreated NHL patients and in 29 healthy subjects. Significantly higher (p < 0.001) levels of palmitic (16:0), oleic (18:1 n-9) and arachidonic acids (20:4 n-6), saturated and monounsaturated FA were found in NHL patients, while linoleic acid (18:2 n-6) and the levels of total polyunsaturated FA (PUFA), n-3 PUFA, eicosapentaenoic (20:5 n-3) and docosahexaenoic (DHA, 22:6 n-3) were significantly reduced (p < 0.01). The level of ole...