MedWorm: Hematology

FDA Panel Turns Down Bone Drug in Prostate Ca

MedPage Today Hematology/Oncology — Wed, 08 Feb 2012 20:43:08 +0100

WASHINGTON (MedPage Today) -- An FDA panel has voted 12-1 against expanding the indication for Amgen's denosumab (Xgeva) to prevent the spread of prostate cancer to the bones in men with a high-risk form of the disease. (Source: MedPage Today Hematology/Oncology)

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Roche Breast Cancer Drug Gets FDA Priority ReviewRoche Breast Cancer Drug Gets FDA Priority Review

Medscape Medical News Headlines — Wed, 08 Feb 2012 18:52:05 +0100

U.S. health regulators granted a priority review for an experimental Roche breast cancer drug that in clinical trials added six months to progression-free survival. Reuters Health Information (Source: Medscape Medical News Headlines)

Slow-Growing Prostate Cancer Is Still 'Real Cancer'Slow-Growing Prostate Cancer Is Still 'Real Cancer'

Medscape Today Headlines — Wed, 08 Feb 2012 17:48:30 +0100

Two prostate cancer experts put forward a strong argument against taking the emotionally charged term "cancer" out of the diagnosis. Medscape Medical News (Source: Medscape Today Headlines)

FDA Staff Says Decitabine No Help in AML

MedPage Today Hematology/Oncology — Wed, 08 Feb 2012 17:40:56 +0100

WASHINGTON (MedPage Today) -- Decitabine (Dacogen), a hypomethylating agent, does not appear to improve mortality in older patients with acute myelogenous leukemia, FDA reviewers concluded. (Source: MedPage Today Hematology/Oncology)

Adjuvant Chemotherapy Slows Gastric CancerAdjuvant Chemotherapy Slows Gastric Cancer

Medscape Today Headlines — Wed, 08 Feb 2012 13:27:06 +0100

When gastric cancer is operable, a chemotherapy combination improves disease-free survival after surgery, according to a large trial. Medscape Medical News (Source: Medscape Today Headlines)

Von Willebrand disease: Clinical and laboratory lessons learned from the large von Willebrand disease studies

American Journal of Hematology — Wed, 08 Feb 2012 05:00:00 +0100

AbstractDuring the past 25 years, our knowledge concerning the pathogenesis, diagnostic strategies and treatment of von Willebrand disease (VWD) has increased significantly. Following the immunological differentiation of factor VIII (FVIII) and von Willebrand factor (VWF) in the 1970s and the cloning of the FVIII and VWF genes in the mid‐1980s, substantial progress has been made in our understanding of this, the most common inherited bleeding disorder. We now recognize that VWD represents a range of genetic diseases all with the clinical endpoint of increased mucocutaneous bleeding. The molecular pathology of Type 2 and Type 3 VWD is now comprehensively documented and involves rare sequence variants at the VWF locus. In contrast, the genetic causation of Type 1 disease remains incomplete...

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Cancer and coagulation

American Journal of Hematology — Wed, 08 Feb 2012 05:00:00 +0100

AbstractThromboembolism, including both venous and arterial events, occurs commonly amongst patients with cancer. The occurrence of thromboembolism has significant consequences for cancer patients, including direct and indirect associations with mortality, morbidity, requirement for long‐term anticoagulant therapy and consumption of healthcare resources. Recent studies have resulted in a better understanding of clinical risk factors and biomarkers of cancer‐associated thrombosis, and a risk assessment model incorporating both has now been validated in multiple settings. Thromboprophylaxis with either unfractionated heparin or low‐molecular‐weight heparins (LMWHs) has been shown to be safe and effective in high‐risk settings such as hospitalization for medical illness and the post...

Interventional approaches to deep vein thrombosis

American Journal of Hematology — Wed, 08 Feb 2012 05:00:00 +0100

AbstractThe last decade has seen increased use of aggressive, catheter‐based methods of treating venous thromboembolism (DVT). In this article, we outline the risks, benefits, and uncertainties surrounding endovascular DVT therapies, describe clinical situations in which endovascular treatment options should reasonably be considered, and update the reader on new outcomes data that pertains to catheter‐based DVT interventions. Endovascular thrombolytic therapy is reasonable to perform for selected patients with DVT causing acute limb‐threatening circulatory compromise, acute IVC occlusion, or acute iliofemoral DVT for the purposes of limb salvage and relief of presenting DVT symptoms, and appears likely to prevent post‐thrombotic syndrome (PTS) in patients with proximal DVT. A multi...

The hope and reality of long acting hemophilia products

American Journal of Hematology — Wed, 08 Feb 2012 05:00:00 +0100

AbstractRecombinant DNA technology and protein engineering are creating hope that we can address ongoing challenges in hemophilia care such as reducing the costs of therapy, increasing the availability to the developing world, and improving the functional properties of these proteins. Technological advances to improve the half‐life of recombinant clotting factors have brought long acting clotting factors for hemophilia replacement therapy closer to reality. Preclinical and clinical trial results are reviewed as well as the potential benefits and risks of these novel therapies. Am. J. Hematol., 2012. © 2012 Wiley‐Liss, Inc. (Source: American Journal of Hematology)

A potent oral P‐selectin blocking agent improves microcirculatory blood flow and a marker of endothelial cell injury in patients with sickle cell disease

American Journal of Hematology — Wed, 08 Feb 2012 05:00:00 +0100

(Source: American Journal of Hematology)

Pachymeningeal involvement in POEMS syndrome: Dramatic cerebral MRI improvement after lenalidomide therapy

American Journal of Hematology — Wed, 08 Feb 2012 05:00:00 +0100

AbstractPOEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, skin changes) syndrome is a rare multisystemic disease associated with plasma cell dyscrasia and increased serum or plasma Vascular Endothelial Growth Factor (VEGF) levels, the latter likely responsible for several POEMS syndrome manifestations. Whereas peripheral neuropathy is the main neurological feature and a mandatory diagnostic criterium, central nervous system involvement is less common except for papilledema and stroke. We recently reported the frequent occurrence at brain MRI of cranial pachymeningeal involvement in a series of POEMS syndrome patients. Meningeal histopathology revealed hyperplasia of meningothelial cells, neovascularisation and obstructive vessel remodelling without inflammatory si...

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Adolescents and young adults with acute lymphoblastic leukemia have a better outcome when treated with pediatric‐inspired regimens ‐ systematic review and meta‐analysis

American Journal of Hematology — Wed, 08 Feb 2012 05:00:00 +0100

Conclusions:Pediatric‐inspired regimens are superior to conventional‐adult chemotherapy in AYA ALL patients. Further randomized controlled studies to investigate this approach in adult ALL patients are warranted. Am. J. Hematol., 2012. © 2012 Wiley‐Liss, Inc. (Source: American Journal of Hematology)

Mitoxantrone, etoposide, cytarabine, and melphalan (NEAM) followed by autologous stem cell transplantation for patients with chemosensitive aggressive non‐hodgkin lymphoma

American Journal of Hematology — Wed, 08 Feb 2012 05:00:00 +0100

In conclusion, NEAM conditioning with auto‐SCT demonstrated considerable efficacy with modest toxicity in patients with chemosensitive aggressive NHL. Am. J. Hematol., 2012. © 2012 Wiley‐Liss, Inc. (Source: American Journal of Hematology)

Cyril Clarke and the prevention of rhesus haemolytic disease of the newborn

British Journal of Haematology — Wed, 08 Feb 2012 05:00:00 +0100

SummaryCyril Clarke was an outstanding general physician and lepidopterist. Late in his career, and stimulated by his work on the genetics of mimicry in butterflies, he became interested in the evolving field of medical genetics. His work on the relationship of blood groups to particular diseases led him and his team in Liverpool to evolve a remarkably successful approach to the prevention of Rhesus haemolytic disease of the newborn. (Source: British Journal of Haematology)

Guidelines on the investigation and management of antiphospholipid syndrome

British Journal of Haematology — Wed, 08 Feb 2012 05:00:00 +0100

(Source: British Journal of Haematology)

Safety of deferasirox in sickle cell disease patients with co‐existing liver impairment – response to Sinakos et al

British Journal of Haematology — Wed, 08 Feb 2012 05:00:00 +0100

(Source: British Journal of Haematology)

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MCL1 down‐regulation plays a critical role in mediating the higher anti‐leukaemic activity of the multi‐kinase inhibitor Sorafenib with respect to Dasatinib

British Journal of Haematology — Wed, 08 Feb 2012 05:00:00 +0100

(Source: British Journal of Haematology)

The homozygous mutation G75R in the human SLC11A2 gene leads to microcytic anaemia and iron overload

British Journal of Haematology — Wed, 08 Feb 2012 05:00:00 +0100

(Source: British Journal of Haematology)

T cell depletion utilizing CD34+ stem cell selection and CD3+ addback from unrelated adult donors in paediatric allogeneic stem cell transplantation recipients

British Journal of Haematology — Wed, 08 Feb 2012 05:00:00 +0100

SummaryCD34‐selected haploidentical and unrelated donor allogeneic stem cell transplantation (AlloSCT) in paediatric recipients is associated with sustained engraftment and low risk of acute graft‐versus‐host disease (aGVHD), but limited by delayed immune reconstitution and increased risk of viral and fungal infection. The optimal dose of donor T cells to prevent graft failure and minimize risk of early opportunistic infection and post‐transplant lymphoproliferative disorder (PTLD), while avoiding severe aGVHD, remains unknown. We prospectively studied CD34‐selected 8–10/10 human leucocyte antigen (HLA)‐matched unrelated donor (MUD) peripheral blood stem cell transplantation (PBSCT) in a cohort of 19 paediatric AlloSCT recipients with malignant (n = 13) or non‐malignant (...

Burkitt lymphoma in UGANDA, the legacy of Denis Burkitt and an update on the disease status

British Journal of Haematology — Wed, 08 Feb 2012 05:00:00 +0100

SummaryBurkitt lymphoma (BL) was first described in Uganda in 1958 as a sarcoma of the jaw but later confirmed to be a distinct form of Non Hodgkin lymphoma (NHL). This discovery was the defining moment of cancer research in Uganda, which eventually led to the establishment of a dedicated cancer research institute, the Uganda Cancer Institute (UCI) in 1967. The centre was dedicated to Denis Burkitt in recognition of his contribution to cancer research in East Africa. BL is still the commonest NHL in childhood in Uganda. Its incidence has significantly increased recently due to yet unknown factors. Although the human immunodeficiency virus (HIV) was considered a possible reason for the increase, there is no evidence that it has substantially impacted on the epidemiology of the disease. Howe...

Denis Parsons Burkitt CMG, MD, DSc, FRS, FRCS, FTCD (1911–93) Irish by birth, Trinity by the grace of God

British Journal of Haematology — Wed, 08 Feb 2012 05:00:00 +0100

SummaryDenis Parsons Burkitt, surgeon and research scientist, is a household name in the medical profession. Denis received his BA in 1933 and graduated as a physician in 1935 from Trinity College, Dublin. After serving as a surgeon in the Royal Army Medicine Corps during World War II, he worked as a surgeon and lecturer in Africa. It was in Africa that he developed exceptional observational and analytical skills, which led him to identify and formally develop a successful treatment for a childhood cancer that is now called Burkitt Lymphoma. The influence of Christianity in his life was huge. Throughout his life he remained extremely modest, attributing much of what he had achieved to the work of others. Denis's contributions to haemato‐oncology remain salient today, and his discoveries ...

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Chronic Lymphocytic Leukemia

Clinical Care Options Oncology - Leukemia — Tue, 07 Feb 2012 15:36:47 +0100

Learning Module - In this CME-certified slideset, John C. Byrd, MD, and Kanti Rai, MD, explore the most compelling data in chronic lymphocytic leukemia presented in San Diego. (Source: Clinical Care Options Oncology - Leukemia)

Avoid Window Seats to Cut Risk for In-Flight Blood Clots: Study

The Doctors Lounge - Cardiology — Tue, 07 Feb 2012 15:00:00 +0100

Experts say DVTs can strike any immobilized passenger, not just those in economy class (Source: The Doctors Lounge - Cardiology)

Expanded Palliative Care for All NSCLC PatientsExpanded Palliative Care for All NSCLC Patients

Medscape Today Headlines — Tue, 07 Feb 2012 13:45:52 +0100

An ASCO provisional clinical opinion recommends that all patients with metastatic nonsmall-cell lung cancer (NSCLC) be offered palliative care concurrent with standard therapy, starting at diagnosis. Medscape Medical News (Source: Medscape Today Headlines)

Active Online Assessment of Patients Using New Oral Anticoagulants: Bleeding Risk, Compliance, and Coagulation Analysis

Seminars in Thrombosis and Hemostasis — Tue, 07 Feb 2012 05:00:00 +0100

Semin Thromb Hemost 2012; 38: 23-30DOI: 10.1055/s-0031-1300948Clinicians prescribing new oral anticoagulants (OACs; dabigatran, rivaroxaban, and apixaban) should be aware of the exclusion criteria related to bleeding risks defined in published clinical studies. At least a quarter of patients currently using warfarin have an exclusion criterion that may prevent easy transition to the new OACs. In the summary of product characteristics for dabigatran, as an example, the target populations appear generalized. Due to fixed dosing and predictable pharmacology, routine laboratory monitoring of new OACs is deemed unnecessary. Under special circumstances, however, understanding the extent of thrombin or factor (F) Xa inhibition may aid in evaluating compliance and handling emergency interventions,...

New Insights into von Willebrand Disease and Platelet Function

Seminars in Thrombosis and Hemostasis — Tue, 07 Feb 2012 05:00:00 +0100

Semin Thromb Hemost 2012; 38: 55-63DOI: 10.1055/s-0031-1300952Regulation of binding between von Willebrand factor (VWF) and the platelet receptor glycoprotein (GP) Ibα is one of the key steps in controlling hemostasis and thrombosis. On vascular injury at sites of high shear rates, the GPIbα interaction with subendothelial-bound VWF will initiate the tethering of circulating platelets to the vessel wall. Tethered platelets subsequently roll on the damaged vessel wall, a process that is amplified by the activation of the platelet integrin αΙΙbβ3 (GPIIb/IIIa). The initial tethering to VWF is rapidly followed by platelet binding to collagen through specific receptors (GPVI and α2β1), leading to firm adhesion, activation, and additional stable bonds mediated by αΙΙbβ3. The above de...

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Hot Topics III

Seminars in Thrombosis and Hemostasis — Tue, 07 Feb 2012 05:00:00 +0100

Semin Thromb Hemost 2012; 38: 01-04DOI: 10.1055/s-0031-1300944Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals:Table of contents | Full text (Source: Seminars in Thrombosis and Hemostasis)

Generation and Breakdown of Soluble Ultralarge von Willebrand Factor Multimers

Seminars in Thrombosis and Hemostasis — Tue, 07 Feb 2012 05:00:00 +0100

Semin Thromb Hemost 2012; 38: 38-46DOI: 10.1055/s-0031-1300950Ultralarge von Willebrand factor (ULVWF) multimeric strings are rapidly secreted by, and anchored to, stimulated endothelial cells (EC), and are hyperadhesive to platelets until cleavage by ADAMTS-13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13). In ADAMTS-13-deficient familial and autoantibody-mediated thrombotic thrombocytopenic purpura (TTP), there is severely restricted cleavage of EC-anchored ULVWF-platelet strings. The small amount of active enzyme released from their EC cleaves ULVWF strings minimally just above EC surfaces, thus generating soluble ULVWF multimers that are 2.5 to 50 times longer than plasma von Willebrand factor (VWF) forms. Soluble ULVWF multimers (detected in TTP an...

Prophylaxis in Children with Hemophilia: Evidence-Based Achievements, Old and New Challenges

Seminars in Thrombosis and Hemostasis — Tue, 07 Feb 2012 05:00:00 +0100

Semin Thromb Hemost 2012; 38: 79-94DOI: 10.1055/s-0031-1300954Recurrent joint bleeding leading to progressive musculoskeletal damage (hemophilic arthropathy), in spite of on-demand replacement with deficient factor concentrates, is the clinical hallmark of severe hemophilia A and B (i.e., the congenital deficiencies of coagulation factors VIII and IX with circulating levels <1 IU/dL). Fifty years of clinical experience, which began in Northern Europe and then initiated in other European countries and in North America, up to the recent randomized clinical trials, have provided definitive evidence that preventing bleeding from an early age through long-term regular prophylactic concentrate infusions limits the adverse clinical consequences of arthropathy and its complications in the quali...

Vitamin D, Thrombosis, and Hemostasis: More than Skin Deep

Seminars in Thrombosis and Hemostasis — Tue, 07 Feb 2012 05:00:00 +0100

Semin Thromb Hemost 2012; 38: 114-124DOI: 10.1055/s-0031-1300957Vitamin D3 deficiency is a highly prevalent condition worldwide. Clinically, vitamin D3 has a key role in calcium homeostasis and bone mineralization and has recently been implicated in the pathogenesis and/or progression of several acute and chronic illnesses, including cardiovascular disease (CVD). Accumulating evidence from observational, prospective studies suggests that low levels of serum 25-hydroxyvitamin D3 are independently associated with an increased risk of CVD events and death. The molecular mechanisms of this association remain incompletely understood. A variety of biologically plausible mechanisms may mediate a cardiovascular role for the active metabolite of vitamin D3. 1-α,25-dihydroxyvitamin D3 regulates the...

The Oral Thrombin Inhibitor Dabigatran: Strengths and Weaknesses

Seminars in Thrombosis and Hemostasis — Tue, 07 Feb 2012 05:00:00 +0100

Semin Thromb Hemost 2012; 38: 07-15DOI: 10.1055/s-0031-1300946Since the quest for a better replacement of warfarin started several decades ago and new compounds were brought forward to clinical trials, the concept of an ideal anticoagulant frequently became presented in lectures and articles. We have here reviewed strengths and weaknesses of the oral thrombin inhibitor dabigatran in terms of pharmacokinetics and clinical data. When strengths clearly exceed the weaknesses for any characteristic, the drug fits into the concept of an ideal anticoagulant in that domain. It is evident that dabigatran does not accomplish that concept for all characteristics but it reaches well above warfarin. We believe it is unlikely that any drug will fulfill all criteria for the ideal anticoagulant. Laborator...

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Thrombin and Cancer: From Molecular Basis to Therapeutic Implications

Seminars in Thrombosis and Hemostasis — Tue, 07 Feb 2012 05:00:00 +0100

Semin Thromb Hemost 2012; 38: 95-101DOI: 10.1055/s-0031-1300955The relationship between cancer and thrombosis has been recognized for nearly 150 years. Although the mechanisms underlying this association are not completely understood, there are increasing evidences suggesting a pivotal role of thrombin in cancer biology. This review will focus on the most important pathways by which thrombin may affect cancer growth and dissemination. In addition, the potential role of congenital (i.e., hemophilia) and pharmaceutical (i.e., antithrombotic agents) anticoagulation in cancer incidence and survival will be investigated through the analysis of the published experimental and clinical studies.[...]Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals:Ta...

Current and Emerging Therapeutics for Heparin-Induced Thrombocytopenia

Seminars in Thrombosis and Hemostasis — Tue, 07 Feb 2012 05:00:00 +0100

The objectives of this review are to discuss currently available drugs for the treatment of HIT, highlight the limitations of these agents, and examine future therapies.[...]Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals:Table of contents | Abstract | Full text (Source: Seminars in Thrombosis and Hemostasis)

Platelet-Derived Microvesicles: Multitalented Participants in Intercellular Communication

Seminars in Thrombosis and Hemostasis — Tue, 07 Feb 2012 05:00:00 +0100

Semin Thromb Hemost 2012; 38: 102-113DOI: 10.1055/s-0031-1300956Platelets can release a heterogeneous pool of vesicles which include plasma membrane-derived microparticles (PMPs) and multivesicular body-derived exosomes. As both vesicle types are generated upon activation and their distinction is complicated due to an overlap in their molecular properties and sizes, they are best discussed as an entity, the platelet-derived microvesicles (PMVs). PMPs can be formed through several induction pathways, which determine their different molecular profiles and facilitate tailor-made participation in intercellular communication. This dynamic variability may lie behind the multifaceted and sometimes very different observations of the PMPs in physiological and pathological settings. Currently, littl...

Welcome to Seminars in Thrombosis & Hemostasis 2012

Seminars in Thrombosis and Hemostasis — Tue, 07 Feb 2012 05:00:00 +0100

Semin Thromb Hemost 2012; 38: 05-06DOI: 10.1055/s-0031-1300945Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals:Table of contents | Full text (Source: Seminars in Thrombosis and Hemostasis)

Thrombotic Microangiopathies, Thrombotic Thrombocytopenic Purpura, and ADAMTS-13

Seminars in Thrombosis and Hemostasis — Tue, 07 Feb 2012 05:00:00 +0100

Semin Thromb Hemost 2012; 38: 47-54DOI: 10.1055/s-0031-1300951Thrombotic microangiopathy (TMA) is a term used to describe a group of disorders characterized by hemolytic anemia (with prominent red blood cell fragmentation), thrombocytopenia, and thrombosis in the microvasculature. It may be used when describing patients with thrombotic thrombocytopenic purpura (TTP), hemolytic uremic syndrome, atypical hemolytic uremic syndrome, as well as a myriad of other disorders in which the TMA may be secondary to another disease or disorder. While limited information exists as to the exact cause of microthrombosis in many TMA, recent advances have been made in the understanding of TTP and its pathophysiology. This progress can be attributed to discovery of the von Willebrand factor cleaving protease...

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Determination of Dabigatran in Human Plasma Samples

Seminars in Thrombosis and Hemostasis — Tue, 07 Feb 2012 05:00:00 +0100

This article reports the effects of dabigatran on clinical routine assays and the potential usefulness for determination in special risk groups of patients when overdose or lack of compliance are suspected.[...]Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals:Table of contents | Abstract | Full text (Source: Seminars in Thrombosis and Hemostasis)

Role of Molecular Genetics in Hemophilia: From Diagnosis to Therapy

Seminars in Thrombosis and Hemostasis — Tue, 07 Feb 2012 05:00:00 +0100

This article reviews the applications of molecular genetics in hemophilia, in general, and how such techniques can be useful for optimizing patient care, in particular.[...]Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals:Table of contents | Abstract | Full text (Source: Seminars in Thrombosis and Hemostasis)

Clinical Performance and Skill Retention after Simulation‐based Education for Nephrology Fellows

Seminars In Dialysis — Tue, 07 Feb 2012 05:00:00 +0100

AbstractWe previously demonstrated that simulation‐based education (SBE) improved temporary hemodialysis catheter (THDC) insertion skills by nephrology fellows. SBE, featuring deliberate practice and rigorous achievement standards, was a powerful method to enhance THDC insertion skills in nephrology fellows. However, experts have called for further research to evaluate skill transfer from the simulated environment to actual clinical care and skill retention. This is a prospective observational cohort study of THDC insertion skills. Twelve nephrology fellows from three academic centers in Chicago were evaluated using a skills checklist from July 2008 to June 2009. Simulator‐trained fellows were tested after the SBE intervention and expected to meet or exceed a minimum passing score (MPS...

Human erythrocyte remodelling during Plasmodium falciparum malaria parasite growth and egress

British Journal of Haematology — Tue, 07 Feb 2012 05:00:00 +0100

SummaryThe intra‐erythrocyte growth and survival of the malarial parasite Plasmodium falciparum is responsible for both uncomplicated and severe malaria cases and depends on the parasite's ability to remodel its host cell. Host cell remodelling has several functions for the parasite, such as acquiring nutrients from the extracellular milieu because of the loss of membrane transporters upon erythrocyte differentiation, avoiding splenic clearance by conferring cytoadhesive properties to the infected erythrocyte, escaping the host immune response by exporting antigenically variant proteins at the red blood cell surface. In addition, parasite‐induced changes at the red blood cell membrane and sub‐membrane skeleton are also necessary for the efficient release of the parasite progeny from ...

Long‐term follow‐up of patients with HIV‐related diffuse large B‐cell lymphomas treated in a phase II study with rituximab and CHOP

British Journal of Haematology — Tue, 07 Feb 2012 05:00:00 +0100

(Source: British Journal of Haematology)

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Androgen-deprivation Therapy and Cardiovascular MortalityAndrogen-deprivation Therapy and Cardiovascular Mortality

Medscape Today Headlines — Tue, 07 Feb 2012 04:00:00 +0100

This meta-analysis looks at the cardiovascular risk associated with androgen-deprivation therapy. Journal Watch (Source: Medscape Today Headlines)

Exemestane for Breast Cancer Prevention Weakens BonesExemestane for Breast Cancer Prevention Weakens Bones

Medscape Today Headlines — Tue, 07 Feb 2012 01:18:28 +0100

Results from a small substudy of patients taking part in a landmark trial that established exemestane for breast cancer prevention show that the drug significantly worsens age-related bone loss. Medscape Medical News (Source: Medscape Today Headlines)

Aromatase Inhibitor Linked to Bone Loss (CME/CE)

MedPage Today Hematology/Oncology — Mon, 06 Feb 2012 23:18:17 +0100

(MedPage Today) -- Taking the aromatase inhibitor exemestane (Aromasin) for primary prevention of breast cancer may weaken the bones, researchers found. (Source: MedPage Today Hematology/Oncology)

New Scoring Method May Help Predict Stroke Outcome

The Doctors Lounge - Cardiology — Mon, 06 Feb 2012 22:00:00 +0100

Study reveals quick way to identify those who will respond well to clot-buster alteplase (Source: The Doctors Lounge - Cardiology)

Long-Term Benefits With Chemoradiation for Bladder CancerLong-Term Benefits With Chemoradiation for Bladder Cancer

Medscape Today Headlines — Mon, 06 Feb 2012 21:40:28 +0100

An analysis of 6 studies shows that bladder preservation therapy with chemotherapy and high-dose radiation is a viable option for patients with less advanced and less bulky disease. Medscape Medical News (Source: Medscape Today Headlines)

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Argos Therapeutics Announces New Data

Kidney Cancer Association — Mon, 06 Feb 2012 18:43:52 +0100

"We observed encouraging clinical and immunologic responses which correlated with prolonged survival," said Robert Figlin M.D., director of the Division of Hematology/Oncology at the Cedars-Sinai Samuel Oschin Comprehensive Cancer Institute and presenter of the new findings.02/07/2012 (Source: Kidney Cancer Association)

Rare Benign Tumor Responds to Cancer Drug

MedPage Today Hematology/Oncology — Mon, 06 Feb 2012 17:53:14 +0100

SAN FRANCISCO (MedPage Today) -- The cancer drug everolimus (Afinitor) appears to shrink a rare type of benign kidney tumor often seen with tuberous sclerosis, researchers found. (Source: MedPage Today Hematology/Oncology)

Refractory pyoderma gangrenosum associated with ulcerative colitis successfully treated with infliximab.

Dermatol Online J — Mon, 06 Feb 2012 12:54:18 +0100

Authors: Ueda M, Katoh M, Tanizaki H, Tanioka M, Matsumura Y, Miyachi Y Abstract Pyoderma gangrenosum (PG) is a rare, immune-mediated ulcerating skin disease. In up to 50 percent of the cases, PG is associated with underlying systemic disorders, most commonly inflammatory bowel diseases, connective tissue diseases, or hematological disorders. Herein, we present a case of refractory PG associated with ulcerative colitis (UC), successfully treated with infliximab. PMID: 22301049 [PubMed - in process] (Source: Dermatol Online J)

Persistent elevation of peripheral blood myeloid cell counts associated with omalizumab therapy.

American Journal of Health-System Pharmacy : AJHP — Mon, 06 Feb 2012 12:07:01 +0100

Conclusion A patient with asthma and common variable immunodeficiency developed an elevation of peripheral blood myeloid cells that was first noticed 29 months after the initiation of monthly omalizumab injections. Omalizumab was discontinued, and the abnormality persisted for 1 month after the last dose. The patient's blood count results remained within normal limits 3 months after the last dose. PMID: 22302255 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)

Super Mover: Dr. Robert L. Saylors III

Arkansas Business - Health Care — Mon, 06 Feb 2012 06:00:00 +0100

Dr. Robert L. Saylors III, an oncologist at Arkansas Children's Hospital in Little Rock, recently was installed in the Jaxon C. Lee-Dr. Robert L. Saylors III Endowed Chair in Pediatric Hematology/Oncology. (Source: Arkansas Business - Health Care)

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The increase from 2.5 to 5 mg/kg of rabbit anti-thymocyte-globulin dose in reduced intensity conditioning reduces acute and chronic GVHD for patients with myeloid malignancies undergoing allo-SCT

Bone Marrow Transplantation — Mon, 06 Feb 2012 05:00:00 +0100

The increase from 2.5 to 5 mg/kg of rabbit anti-thymocyte-globulin dose in reduced intensity conditioning reduces acute and chronic GVHD for patients with myeloid malignancies undergoing allo-SCT Bone Marrow Transplantation advance online publication, February 6, 2012. doi:10.1038/bmt.2012.3 Authors: R Devillier, R Crocchiolo, L Castagna, S Fürst, J El Cheikh, C Faucher, T Prebet, A Etienne, C Chabannon, N Vey, B Esterni & D Blaise (Source: Bone Marrow Transplantation)

High-dose corticosteroids with or without etanercept for the treatment of idiopathic pneumonia syndrome after allo-SCT

Bone Marrow Transplantation — Mon, 06 Feb 2012 05:00:00 +0100

Authors: R Tizon, N Frey, D F Heitjan, K S Tan, S C Goldstein, E O Hexner, A Loren, S M Luger, R Reshef, D Tsai, D Vogl, J Davis, M Vozniak, B Fuchs, E A Stadtmauer & D L Porter (Source: Bone Marrow Transplantation)

Fecal calprotectin in allogeneic stem cell transplantation for the diagnosis of acute intestinal graft versus host disease

Bone Marrow Transplantation — Mon, 06 Feb 2012 05:00:00 +0100

Authors: M Bastos Oreiro, C Castilla-Llorente, A L de la Guía, R de Paz, M Van Domselaar, J Nieto, A Rodriguez, D Gallardo & M Canales (Source: Bone Marrow Transplantation)

Postradiation Cutaneous Angiosarcoma After Breast CancerPostradiation Cutaneous Angiosarcoma After Breast Cancer

Medscape Today Headlines — Mon, 06 Feb 2012 04:00:00 +0100

This study compared MYC expression in these patients with control cases. Modern Pathology (Source: Medscape Today Headlines)

Sunitinib in Advanced Pancreatic Neuroendocrine Tumors Sunitinib in Advanced Pancreatic Neuroendocrine Tumors

Medscape Today Headlines — Mon, 06 Feb 2012 04:00:00 +0100

New hope for patients with well-differentiated pancreatic neuroendocrine tumors may be close at hand. Therapeutic Advances in Medical Oncology (Source: Medscape Today Headlines)

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Imatinib and beyond - targeting activated tyrosine kinases in myeloproliferative disorders.

Onkologie — Mon, 06 Feb 2012 02:58:36 +0100

Authors: Hochhaus A, Reiter A, Ernst T, La Rosée P Abstract Tyrosine kinases (TKs) play a major role in cellular signal transduction. Deregulated TK activity has been observed in solid cancers and hematologic malignancies. Advances in the understanding of the oncogenic activation of TKs led to the identification of new kinase inhibitors with improved potency, specificity, and efficacy. With the advent of imatinib mesylate, a new era in the management of patients with BCR-ABL+ chronic myelogenous leukemia (CML), gastrointestinal stromal tumors, and myeloproliferative neoplasms including chronic myelomonocytic leukemia with PDGFRB gene rearrangements and hypereosinophilic syndrome has begun. CML represents a model for the rational design of TK inhibitors based on the insights into s...

Abbreviated Radiotherapy Shows Promise in Prostate Ca

MedPage Today Hematology/Oncology — Sun, 05 Feb 2012 20:43:08 +0100

SAN FRANCISCO (MedPage Today) -- Dramatically condensing radiation treatment for early prostate cancer into just five fractions produces good results without much toxicity, an early-phase study suggested. (Source: MedPage Today Hematology/Oncology)

Iron therapy in patients with chronic kidney disease

Transfusion Alternatives in Transfusion Medicine — Sun, 05 Feb 2012 05:00:00 +0100

SUMMARYIron deficiency, both functional and absolute, is common in patients with chronic kidney disease and in those requiring dialysis. The Renal National Service Framework and National Institute for Health and Clinical Excellence advocate treatment of anemia in patients with chronic kidney disease. Oral iron is often both insufficient and slow to improve hemoglobin levels while intravenous supplementation replenishes and maintains iron stores more effectively. This leads to a reduction in the use of erythropoietin stimulating agents. This reduction in erythropoietin stimulating agents use may be potentially beneficial in certain cases in particularly reducing stroke risk. In contrast, intravenous iron has the potential to improve quality of life, reduce cardiovascular risk and produce co...

Donor disclosure – a donor's right and blood bank's responsibility

Transfusion Alternatives in Transfusion Medicine — Sun, 05 Feb 2012 05:00:00 +0100

This study describes our experiences in counseling donors who were enzyme‐linked immunosorbent assay reactive for viral TTI, and challenges faced in implementing the donor disclosure program in a resource‐limited environment. (Source: Transfusion Alternatives in Transfusion Medicine)

Vaccine Eyed for Early-Stage Prostate Ca

MedPage Today Hematology/Oncology — Sat, 04 Feb 2012 23:03:35 +0100

SAN FRANCISCO (MedPage Today) -- The immunotherapy agent sipuleucel-T (Provenge) appears safe for use earlier in prostate cancer, researchers found. (Source: MedPage Today Hematology/Oncology)

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Bone Drug Slows Mets in Aggressive Prostate Ca

MedPage Today Hematology/Oncology — Sat, 04 Feb 2012 22:57:55 +0100

SAN FRANCISCO (MedPage Today) -- Denosumab (Xgeva) delays onset of bone metastases for even the highest risk prostate cancer patients, researchers found. (Source: MedPage Today Hematology/Oncology)

Aspirin, Warfarin Fare Equally for Heart Failure Patients

The Doctors Lounge - Cardiology — Sat, 04 Feb 2012 05:00:00 +0100

Each of these anti-clotting drugs had similar effectiveness in preventing deaths, study found (Source: The Doctors Lounge - Cardiology)

Myeloproliferative Neoplasms

Springer Medicine titles — Sat, 04 Feb 2012 00:09:38 +0100

Critical Concepts and Managementseries:Hematologic MalignanciesMyeloproliferative neoplasms (MPNs) are clonal stem cell diseases that, under the World Health Organization classification, are subcategorized into eight clinicopathologic entities. The current book focuses on three of these categories: polycythemia vera, essential thrombocythemia, and primary myelofibrosis. A number of important questions regarding the diagnosis, prognosis, and treatment of ... (Source: Springer Medicine titles)

Robotic Surgery: Ready for Prime Time in Endometrial Cancer?Robotic Surgery: Ready for Prime Time in Endometrial Cancer?

Medscape Today Headlines — Fri, 03 Feb 2012 21:20:17 +0100

Laparoscopic hysterectomy reduces complications and improves quality of life, but it is still not widely embraced, and the benefits of robotic surgery remain unclear. Medscape Medical News (Source: Medscape Today Headlines)

World Cancer Day Emphasizes PreventionWorld Cancer Day Emphasizes Prevention

Medscape Today Headlines — Fri, 03 Feb 2012 19:37:35 +0100

World Cancer Day 2012 will focus on preventing cancer and emphasize that up to one third of common cancers can be prevented by lifestyle changes. Medscape Medical News (Source: Medscape Today Headlines)

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Lawmaker Calls for Bipartisan Support for Cancer ResearchLawmaker Calls for Bipartisan Support for Cancer Research

Medscape Today Headlines — Fri, 03 Feb 2012 18:02:52 +0100

According to one researcher, cancer is having its AZT moment. Medscape Medical News (Source: Medscape Today Headlines)

Baseline NT-proBNP and biomarkers of inflammation and necrosis in patients with ST-segment elevation myocardial infarction: insights from the APEX-AMI trial

Journal of Thrombosis and Thrombolysis — Fri, 03 Feb 2012 17:52:05 +0100

Abstract Coronary plaque rupture is associated with a systemic inflammatory response. The relationship between baseline N-terminal pro B-type natriuretic peptide (NT-proBNP), a prognostic marker in patients with acute coronary syndromes, and systemic inflammatory mediators in patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI) is not well described. Of 5,745 STEMI patients treated with primary PCI in the APEX-AMI trial, we evaluated the relationship between baseline NT-proBNP levels and baseline levels of inflammatory markers and markers of myonecrosis in a subset of 772 who were enrolled in a biomarker substudy. Spearman correlations (r s) were calculated between baseline NT-proBNP levels and a pan...

Efficacy of zoledronic acid in postmenopausal Japanese women with early breast cancer receiving adjuvant letrozole: 12-month results

Breast Cancer Research and Treatment — Fri, 03 Feb 2012 17:52:05 +0100

Abstract Aromatase inhibitor-associated bone loss has not been proved in the Japanese or Asian women. The aim of this study was to evaluate an upfront or delayed strategy of bone protection therapy with zoledronic acid administered at 4 mg every 6 months in postmenopausal Japanese women with early breast cancer to compare with results of the Z-FAST and ZO-FAST studies in western countries. Postmenopausal women with hormone receptor positive early breast cancer receiving adjuvant letrozole were randomly assigned to receive either upfront or delayed-start zoledronic acid (4 mg intravenously every 6 months). The delayed group received zoledronic acid when lumbar spine (L2–L4) bone mineral density (BMD) decreased to less than young adult mean −2.0SD or w...

Prognostic significance of T cell subsets in peripheral blood of B cell non-Hodgkin’s lymphoma patients

Medical Oncology — Fri, 03 Feb 2012 17:51:42 +0100

Abstract The role of tumor-infiltrating T cell subsets in the prognosis of non-Hodgkin’s lymphoma (NHL) has previously been reported. In the present study, we investigated the prognostic significance of different T cell subsets in the peripheral blood of NHL patients. Immunophenotyping was performed on the peripheral blood samples of 45 patients with newly diagnosed B cell NHL using flow cytometry. The relationship between T cell subsets of CD4+, CD8+, CD3+CD25+, CD4+CD25+, CD4+CD25high [as T regulatory cells (T reg)], and the CD4/CD8 ratio with international prognostic index (IPI) and response to therapy was determined. The percentages of CD3+, CD4+, and CD8+ T cells in the peripheral blood of the patients were 49.1 ± 20.3%, 23.6 ± 11%, and 31....

Nine years interval between first and second bone marrow transplantations and subsequent long-term survival—a case of acute myeloid leukemia with MLL-AF6 fusion gene

Annals of Hematology — Fri, 03 Feb 2012 17:12:41 +0100

Content Type Journal ArticleCategory Letter to the EditorPages 1-3DOI 10.1007/s00277-012-1417-2Authors Yasuhisa Yokoyama, Department of Hematology, Faculty of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, JapanKazumi Suzukawa, Department of Hematology, Faculty of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, JapanYasushi Okoshi, Department of Hematology, Faculty of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, JapanToru Nanmoku, Department of Clinical Laboratory, Tsukuba University Hospital, Tsukuba, Ibaraki, JapanNaoshi Obara, Department of Hematology, Faculty of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, JapanTerukazu Enami, Department of Hematology, Faculty of Medicine, University of Tsukuba, ...

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Antibodies in the Treatment of Aplastic Anemia

Archivum Immunologiae et Therapiae Experimentalis — Fri, 03 Feb 2012 17:10:31 +0100

Abstract Antibodies have been the cornerstone of treatment of acquired aplastic anemia for more than 25 years. Treatment with antithymocyte globulin (ATG) is considered pivotal and the addition of cyclosporine improves the overall response rate. This antibody is heterogeneous and horse ATG is apparently more effective than rabbit ATG. Several issues remain unsolved in relation to the combination of ATG and cyclosporine: cost, toxicity and late clonal disorders. In recent years, alternative immunosuppressive therapy has been proposed and new antibodies have emerged: porcine ATG, alemtuzumab, daclizumab, and rituximab. Experience with these antibodies is limited to a few studies with alemtuzumab being the most promising, but the results are interesting and provocative. ...

EMR: Efficiency Mauled Repeatedly EMR: Efficiency Mauled Repeatedly

Medscape Today Headlines — Fri, 03 Feb 2012 15:21:19 +0100

Dr. John Marshall says that his efficiency as a clinician is undermined as he spends more and more time entering data into the EMR with less and less administrative support. Is there a way out? Medscape Hematology-Oncology (Source: Medscape Today Headlines)

Could a Blood Test Help Spot Depression?

The Doctors Lounge - Psychiatry — Fri, 03 Feb 2012 15:00:00 +0100

Small study suggests 'biomarker' levels might help support a diagnosis, but more research needed (Source: The Doctors Lounge - Psychiatry)

Lung Tumor Grows, but Must Chemo Change?Lung Tumor Grows, but Must Chemo Change?

Medscape Today Headlines — Fri, 03 Feb 2012 14:49:43 +0100

Dr. Mark Kris discusses cancer progression, as defined by RECIST criteria, and the situations in which increased tumor size in NSCLC need not prompt a change in standard chemotherapy. Medscape Hematology-Oncology (Source: Medscape Today Headlines)

Leukopenia and thrombocytopenia induced by etanercept: two case reports and literature review

Revista Brasileira de Reumatologia — Fri, 03 Feb 2012 10:19:07 +0100

We report two cases of bicytopenia induced by etanercept. Both cases recovered after drug withdrawal. We discuss the need of introduction of routine laboratorial tests in patients using anti-TNF therapy, in order to identify possible hematological changes (Source: Revista Brasileira de Reumatologia)

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Apparent heparin resistance in a patient with infective endocarditis secondary to elevated factor VIII levels

Journal of Thrombosis and Thrombolysis — Fri, 03 Feb 2012 07:22:02 +0100

Abstract Heparin resistance (HR) is defined as increasing requirements of heparin to maintain a therapeutic activated partial thromboplastin time (aPTT). It is commonly associated with antithrombin deficiency, increased heparin clearance and elevations in heparin binding proteins. Elevated factor VIII levels can cause decrease the aPTT levels (anticoagulant effect) without disturbing heparin activity measured by anti-Xa assay (antithrombotic effect) leading to an apparent heparin resistant state rather than a true heparin resistance. We highlight the importance of increasing awareness of apparent HR and early distinction from true resistance to avoid major life threatening hemorrhagic complications. We hereby report an unusual case of heparin resistance due to increased fa...

Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for the Treatment of Peritoneal Sarcomatosis

Annals of Surgical Oncology — Fri, 03 Feb 2012 07:21:20 +0100

Conclusions A complete cytoreduction and low PCI score appear to be important factors in considering CRS and HIPEC for patients with peritoneal sarcomatosis. Content Type Journal ArticleCategory Regional Cancer TherapiesPages 1-6DOI 10.1245/s10434-012-2240-7Authors George I. Salti, Division of Surgical Oncology, Department of Surgery, The University of Illinois at Chicago, Chicago, IL, USALuay Ailabouni, Division of Surgical Oncology, Department of Surgery, The University of Illinois at Chicago, Chicago, IL, USASamir Undevia, Division of Hematology and Oncology, The University of Chicago, Chicago, IL, USA Journal Annals of Surgical OncologyOnline ISSN 1534-4681Print ISSN 1068-9265 (Source: Annals of Surgical Oncology)

Caregiver burden among nocturnal home hemodialysis patients

Hemodialysis International — Fri, 03 Feb 2012 05:00:00 +0100

AbstractRecent studies have suggested improvements in quality of life (QOL) in patients on quotidian dialysis compared with conventional hemodialysis. Few studies have focused on the burden and QOL in caregivers of patients with end‐stage renal disease (ESRD) on nocturnal home hemodialysis (NHD). We aim to assess the caregivers’ burden, QOL, and depressive symptoms and to compare these parameters with their patients’ counterparts. Cross‐sectional surveys were sent to 61 prevalent NHD patients and their caregivers. Surveys assessed demographics, general self‐perceived health using the 12‐Item Short Form Health Survey (SF‐12) and the presence of depression using the Beck Depression Inventory. Subjective burden on caregivers was assessed by the Caregiver Burden scale and was com...

Necrotizing fasciitis of thigh associated with EscherichiaColi bacteremia in a patient on chronic hemodialysis

Hemodialysis International — Fri, 03 Feb 2012 05:00:00 +0100

We present a 59‐year‐old male on chronic hemodialysis (HD). We made the diagnosis of necrotizing fasciitis of the right thigh due to the crepitus from physical examination and subcutaneous emphysema from an X film. He was successfully treated with antibiotics and surgical debridement. The blood and surgical drainage cultures showed Escherichia coli, which is less commonly seen in cutaneous infection. The colonoscopic finding revealed adenomatous polyps. Necrotizing fasciitis in patients on HD requires early diagnosis and aggressive treatment to ensure the favorable clinical outcomes. (Source: Hemodialysis International)

Abiraterone for Prostate Cancer Gets a 'No' in the UKAbiraterone for Prostate Cancer Gets a 'No' in the UK

Medscape Today Headlines — Thu, 02 Feb 2012 20:48:23 +0100

The news has sparked outrage because the drug was developed in the United Kingdom in research funded by public donations. Medscape Medical News (Source: Medscape Today Headlines)

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Most Common Tx for Prostate Ca Not Best Value

MedPage Today Hematology/Oncology — Thu, 02 Feb 2012 20:43:07 +0100

SAN FRANCISCO (MedPage Today) -- External beam radiation is the most toxic and expensive among common prostate cancer treatments over the long-term, a national registry study suggested. (Source: MedPage Today Hematology/Oncology)

Drug Shortages Are Speeding Cancer Deaths, Survey SaysDrug Shortages Are Speeding Cancer Deaths, Survey Says

Medscape Today Headlines — Thu, 02 Feb 2012 19:20:17 +0100

A survey of American oncologists indicates that drug shortages are not a benign commercial problem. Medscape Medical News (Source: Medscape Today Headlines)

Proton Beam No Better than IMRT for Prostate Cancer (CME/CE)

MedPage Today Hematology/Oncology — Thu, 02 Feb 2012 18:48:22 +0100

SAN FRANCISCO (MedPage Today) -- For localized prostate cancer, proton beam radiation offers no advantage in minimizing recurrences or side effects, study results suggested. (Source: MedPage Today Hematology/Oncology)

Kinetics of blood CD34+ cells after chemotherapy plus G-CSF in poor mobilizers: Implications for pre-emptive plerixafor use

Annals of Hematology — Thu, 02 Feb 2012 18:15:06 +0100

Abstract Mobilization and collection of stem cells is difficult in a proportion of patients intended for autologous stem cell transplantation (ASCT). We have evaluated mobilization kinetics of blood CD34+ cells (B-CD34+) to form basis for algorithm to facilitate rational pre-emptive plerixafor use. Altogether 390 chemomobilized patients were included. Forty-three patients (11%) did not reach B-CD34+ count ≥10 × 106/l. Mobilization kinetics differed according to the mobilization capacity observed. Among those who were very poor or inadequate mobilizers (peak B-CD34+ count ≤5 × 106/l and 6–10 × 106/l, respectively), B-CD34+ counts rarely rose after white blood cells (WBC) >5–10 × 109/l, whereas in many standard mobilizers a later rise in CD34+ cou...

Allogeneic transplantation of umbilical cord-derived mesenchymal stem cells for diffuse alveolar hemorrhage in systemic lupus erythematosus

Clinical Rheumatology — Thu, 02 Feb 2012 18:14:31 +0100

This study aimed to assess the efficacy of UC-MSCT in the treatment of SLE-associated DAH. Four SLE patients complicated with DAH, who underwent UC-MSCT, were included. Clinical changes before and after transplantation were assessed by measurements of hemoglobin, platelet level, oxygen saturation, and serological factors. High-resolution CT (HRCT) scans of the chest were performed to evaluate pulmonary manifestation. All the four patients showed dramatic improvements of their clinical manifestations. Hemoglobin was elevated after UC-MSCT and was sustained at a normal level 6 months after UC-MSCT in the four patients. Platelet level was upregulated in two patients who had thrombocytopenia at baseline. Oxygen saturation appeared to be normal at 1 month after UC-MSCT, and this...

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Biochemical predictors of cardiac rhythm at 1 year follow-up in patients with non-valvular atrial fibrillation

Journal of Thrombosis and Thrombolysis — Thu, 02 Feb 2012 18:12:07 +0100

Abstract C-reactive protein (CRP) is increased in patients with atrial fibrillation (AF) and it might predict the lack of sinus rhythm maintenance in the long term follow-up. Scarce data have been reported relating endothelial dysfunction and/or haemostatic or platelet markers to sinus rhythm maintenance in AF patients. We aimed to determine whether some biochemical markers including soluble thrombomodulin (sTM), soluble P-selectin, thrombin–antithrombin (TAT) complex and CRP levels could predict sinus rhythm maintenance at 1 year follow-up in non-valvular AF patients. 130 patients (70 males, mean age 67 ± 13 years) with newly diagnosed AF naïve of antithrombotic or antiplatelet therapy were studied. Baseline CRP, P-selectin, sTM and TAT levels were ...

Workouts Shape Up Genes, Prognosis in Prostate Ca (with audio)

MedPage Today Hematology/Oncology — Thu, 02 Feb 2012 16:38:08 +0100

SAN FRANCISCO (MedPage Today) -- Regular vigorous exercise tones down tumor promoter genes and up regulates tumor suppressor genes for men with prostate cancer, researchers found. (Source: MedPage Today Hematology/Oncology)

Efforts to Reduce Stroke in Kids With Sickle Cell Working: Study

The Doctors Lounge - Hematology — Thu, 02 Feb 2012 15:00:00 +0100

Ultrasound screening, regular blood transfusions have helped reduce strokes in those with the blood disorder (Source: The Doctors Lounge - Hematology)

What is the Evidence for the use of Adrenaline in the Treatment of Neonatal Hypotension?

Thu, 02 Feb 2012 14:05:42 +0100

(Source: Cardiovascular and Hematological Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Cardiovascular and Hematological Agents))

30 Years Lost in Anesthesia Theory

Thu, 02 Feb 2012 14:05:42 +0100

(Source: Cardiovascular and Hematological Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Cardiovascular and Hematological Agents))

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Cardiovascular Aspect of Beta-Thalassaemia

Thu, 02 Feb 2012 14:05:42 +0100

(Source: Cardiovascular and Hematological Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Cardiovascular and Hematological Agents))

Experience with Multiplex ARMS (MARMS)-PCR for the Detection of Common Thalassemia Mutations in India

Thu, 02 Feb 2012 14:05:42 +0100

(Source: Cardiovascular and Hematological Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Cardiovascular and Hematological Agents))

Community Expansion and Gene Geography of Sickle Cell Trait and G6PD Deficiency, and Natural Selection against Malaria: Experience from Tribal Land of India

Thu, 02 Feb 2012 14:05:42 +0100

(Source: Cardiovascular and Hematological Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Cardiovascular and Hematological Agents))

Editorial from Guest Editor [ Hot Topic:Current Status of Therapeutics and Preventive Measures for Patients with Thalassaemia and Sickle Cell Disease (Guest Editor: P.H. Reddy)]

Thu, 02 Feb 2012 14:05:42 +0100

(Source: Cardiovascular and Hematological Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Cardiovascular and Hematological Agents))

Hyperbaric O2 Helps Most Chronic Radiation Injuries: StudyHyperbaric O2 Helps Most Chronic Radiation Injuries: Study

Medscape Hematology-Oncology Headlines — Thu, 02 Feb 2012 11:19:19 +0100

Hyperbaric oxygen improves most cases of chronic radiation tissue injury, according to a large single-center report. Reuters Health Information (Source: Medscape Hematology-Oncology Headlines)

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Primary MALT lymphoma of the urinary bladder in the background of interstitial cystitis

Annals of Hematology — Thu, 02 Feb 2012 06:56:37 +0100

Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s00277-012-1419-0Authors Ken Morita, Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655 JapanFumihiko Nakamura, Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655 JapanYasuhito Nannya, Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655 JapanAkira Nomiya, Department of Urology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655 JapanShunya Arai, Department of Hematology and Oncology, Graduate School of Medicine, The University...

Competence and sporulation factor derived from Bacillus subtilis improves epithelial cell injury in intestinal inflammation via immunomodulation and cytoprotection

International Journal of Colorectal Disease — Thu, 02 Feb 2012 06:54:28 +0100

Conclusion Therefore, CSF is a potentially effective treatment for intestinal inflammation. Content Type Journal ArticleCategory Original ArticlePages 1-8DOI 10.1007/s00384-012-1416-8Authors Kotaro Okamoto, Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, 2-1, Midorigaoka-higashi, Asahikawa, Hokkaido 078-8510, JapanMikihiro Fujiya, Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, 2-1, Midorigaoka-higashi, Asahikawa, Hokkaido 078-8510, JapanToshie Nata, Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, 2-1, Midorigaoka-higashi, Asahikawa, Hokkaido 078-8510, JapanNobuhiro Ueno, Division of Gastroent...

Kinetics of bilirubin and liver enzymes is useful for predicting of liver graft-versus-host disease.

Neoplasma — Thu, 02 Feb 2012 05:00:00 +0100

Authors: Krejci M, Kamelander J, Pospisil Z, Mayer J Abstract Graft-versus-host disease (GVHD) is the most frequent complication after allogeneic hematopoietic cell transplantation. We analyzed the kinetics of bilirubin and liver enzymes in 47 cases with liver GVHD and in 47 cases without GVHD after allogeneic transplantation for various hematological malignancies. The duration of an liver GVHD episode (LGVHD) was defined as the interval from the point when the criteria of LGVHD were met to the decrease to < 2 upper normal limit (UNL) for aminotransferases or bilirubin < 34 mmol/l for bilirubin. The imminent LGVHD episode was defined as the interval from the start of continuous increase (≥ 3 consecutive rising values) of bilirubin and liver enzymes above UNL to the point of...

Gemcitabine and docetaxel (GEMDOX) for the treatment of relapsed and refractory pediatric sarcomas

Pediatric Blood and Cancer — Thu, 02 Feb 2012 05:00:00 +0100

ConclusionsThe dismal outcomes for patients with relapsed and refractory sarcomas and the lack of effective sarcoma salvage regimens highlight the need for new approaches. This report of the therapeutic activity of gemcitabine and docetaxel (GEMDOX) in rhabdomyosarcoma and other pediatric reports describing activity in osteosarcoma and Ewing sarcoma suggest that this combination should be considered for formal evaluation in a pediatric specific clinical trial. At a minimum, it appears to offer a reasonable, tolerable, palliative option. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer)

Current understanding of the mechanism of benzene-induced leukemia in humans: implications for risk assessment

Carcinogenesis — Thu, 02 Feb 2012 05:00:00 +0100

Benzene causes acute myeloid leukemia and probably other hematological malignancies. As benzene also causes hematotoxicity even in workers exposed to levels below the US permissible occupational exposure limit of 1 part per million, further assessment of the health risks associated with its exposure, particularly at low levels, is needed. Here, we describe the probable mechanism by which benzene induces leukemia involving the targeting of critical genes and pathways through the induction of genetic, chromosomal or epigenetic abnormalities and genomic instability, in a hematopoietic stem cell (HSC); stromal cell dysregulation; apoptosis of HSCs and stromal cells and altered proliferation and differentiation of HSCs. These effects modulated by benzene-induced oxidative stress, aryl hydrocarb...

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Mechanisms of Alloimmunization and Subsequent Bone Marrow Transplantation Rejection Induced by Platelet Transfusion in a Murine Model

American Journal of Transplantation — Thu, 02 Feb 2012 05:00:00 +0100

For many nonmalignant hematological disorders, HLA‐matched bone marrow transplantation (BMT) is curative. However, due to lack of neoplasia, the toxicity of stringent conditioning regimens is difficult to justify, and reduced intensity conditioning is used. Unfortunately, current reduced intensity regimens have high rates of BMT rejection. We have recently reported in a murine model that mHAs on transfused platelet products induce subsequent BMT rejection. Most nonmalignant hematological disorders require transfusion support prior to BMT and the rate of BMT rejection in humans correlates with the number of transfusions given. Herein, we perform a mechanistic analysis of platelet transfusion‐induced BMT rejection and report that unlike exposure to alloantigens during transplantation, pl...

Deregulation of apoptosis-related genes is associated with PRV1 overexpression and JAK2 V617F allele burden in Essential Thrombocythemia and Myelofibrosis

Journal of Hematology and Oncology — Thu, 02 Feb 2012 05:00:00 +0100

Conclusions: Our results suggest the participation of intrinsic apoptosis pathway in the MPN physiopathology. In addition, PRV1 and JAK2 V617F allele burden were linked to deregulation of the apoptotic machinery. (Source: Journal of Hematology and Oncology)

Current status of additive solutions for platelets

Journal of Clinical Apheresis — Thu, 02 Feb 2012 05:00:00 +0100

AbstractThe storage of platelets in additive solution (PAS) had lagged behind red cell concentrates, especially in North America. The partial or complete removal of anticoagulated plasma and storage of platelet concentrates in AS presents many advantages. The PAS can be formulated to optimize aerobic metabolism or decrease platelet activation, thus abrogating the platelet storage lesion and potentially improving in vivo viability. Plasma removal has been shown to reduce allergic reactions and the plasma harvested could contribute to the available plasma pool for transfusion or fractionation. PAS coupled to pathogen reduction technology results in a platelet product of equivalent hemostatic efficacy to conventionally stored platelets. Given the above, the likely future direction of platelet...

The effective use of plerixafor as a real‐time rescue strategy for patients poorly mobilizing autologous CD34+ cells

Journal of Clinical Apheresis — Thu, 02 Feb 2012 05:00:00 +0100

AbstractPlerixafor enhances CD34+ cell mobilization, however, its optimal use is unknown. We hypothesized that plerixafor could “rescue” patients in the midst of mobilization when factors indicated a poor CD34+ yield. Of 295 consecutive autologous peripheral blood mobilization attempts at our center, 39 (13%) used plerixafor as rescue strategy due to a CD34+ cell concentration <10/μl (median 5.95/μl, n = 30), low CD34+ cell yield from prior apheresis day (median 1.06 × 106 CD34+ cells/kg, n = 7), or other (n = 2). Patients received a median of one plerixafor dose (range: 1–4). Thirty‐four (87%) collected =2 × 10 6 CD34+ cells/kg and 26 (67%) collected =4 × 10 6 CD34+ cells/kg. Median collections for lymphoma (n = 24) and myeloma (n = 15) patients were 4.1 × 106 and 8.3 × ...

Predictive factors for inadequate stem cell mobilization in Chinese patients with NHL and HL: 14‐year experience of a single‐center study

Journal of Clinical Apheresis — Thu, 02 Feb 2012 05:00:00 +0100

Conclusion: Our analysis showed that high amounts of chemotherapy, radiotherapy, low platelet count, chemosensitive recurrent patients, combination chemotherapy plus G‐CSF and low CD34+ cells in BM prior to mobilization could emerged as important predictive factors for mobilization failure in Chinese patients with NHL and HL. J. Clin. Apheresis, 2012. © 2012 Wiley Periodicals, Inc. (Source: Journal of Clinical Apheresis)

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Doubts concerning functional endothelial nitric oxide synthase in human erythrocytes