MedWorm: Hematology

Treatment of septic patients with an arginine-based endotoxin adsorber column improves hemodynamics and reduces oxidative stress: results of a feasibility study

Blood Purification — Sat, 17 May 2008 14:39:55 +0100

Blood Purif 2008;26:333-339 (DOI:10.1159/000132464) (Source: Blood Purification)

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Strong association between nutritional markers and arterial stiffness in continuous ambulatory peritoneal dialysis patients

Blood Purification — Sat, 17 May 2008 14:39:55 +0100

Blood Purif 2008;26:340-346 (DOI:10.1159/000132465) (Source: Blood Purification)

Double-filtration plasmapheresis in the treatment of leg ulcers in cryoglobulinemia

Journal of Clinical Apheresis — Sat, 17 May 2008 04:00:00 +0100

Hepatitis C virus (HCV) is the major cause of cryoglobulinemia. Skin lesions are frequent and can be cured from the removal of cryoglobulins by therapeutic apheresis. We describe a case of HCV-positive type I cryoglobulinemia with severe leg ulcers, not responsive to antiviral and immunosuppressive treatment. Thirty sessions of double filtration plasmapheresis were performed, over a period of 6 months, with no other associated treatment. Before and after each session an assessment of immunoglobulins, complement, cryocrit, and fibrinogen was made. HCV RNA levels were determined in serum cryoprecipitate, supernatant before and after each session, and in the collection bag. No differences in pre and postapheresis values were observed in the serum concentrations and the supernatant, whereas the postapheresis cryoprecipitate showed a significantly reduced viral load (P < 0.02) as compared with the preapheresis values. There was improvement in the condition of ulcers in the leg during apheresis and had completely regressed by the end of the cycle. J. Clin. Apheresis, 2008. © 2008 Wiley-Liss, Inc. (Source: Journal of Clinical Apheresis)

Asco: mtor inhibitor delays progression of metastatic renal cell carcinoma

MedPage Today Hematology/Oncology — Fri, 16 May 2008 21:32:42 +0100

NEW YORK -- More than 60% of metastatic kidney cancer patients taking an investigational mTOR inhibitor had a delay in progression of their disease, researchers here said. (Source: MedPage Today Hematology/Oncology)

Missing mutations hold clue to imatinib (gleevec) gist resistance

MedPage Today Hematology/Oncology — Fri, 16 May 2008 20:23:09 +0100

PHILADELPHIA -- Some patients with gastrointestinal stromal tumors (GIST) who are imatinib (Gleevec)-resistant don't respond because they are missing the mutations in two genes that are usually integral to the illness. Now researchers here have found out what may be causing their disease. (Source: MedPage Today Hematology/Oncology)

Ons: cancer fatigue is more than just feeling tired

MedPage Today Hematology/Oncology — Fri, 16 May 2008 18:43:43 +0100

PHILADELPHIA -- Fatigue associated with cancer radiotherapy is more complex than is generally recognized and should be thoroughly explored in patients reporting fatigue symptoms, a researcher said here. (Source: MedPage Today Hematology/Oncology)

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Anaemia and cigarette smoking.

International Journal of Laboratory Hematology — Fri, 16 May 2008 16:42:57 +0100

Anaemia and cigarette smoking.

Int J Lab Hematol. 2008 Jun;30(3):177-84

Authors: Leifert JA

Cigarette smoking causes numerous diseases that are associated with anaemia but the resulting low haemoglobin levels may be counterbalanced by increased red blood cell production caused by chronic exposure to carbon monoxide from cigarette smoke. Diverse mechanisms are involved in influencing the development or the course of anaemic disease in smokers. This article presents an evaluation of the current literature on the impact of cigarette smoking on various forms of anaemia.

PMID: 18479294 [PubMed - in process]

(Source: International Journal of Laboratory Hematology)

Conjugation of methotrexate to immunoglobulins kills macrophages by f(c) receptor mediated uptake?

International Journal of Laboratory Hematology — Fri, 16 May 2008 16:42:53 +0100

Conjugation of methotrexate to immunoglobulins kills macrophages by F(c) receptor mediated uptake?

Int J Lab Hematol. 2008 Jun;30(3):185-90

Authors: Wang X, Yao C, Jiang Z

The aim of this study was to conjugate methotrexate (MTX) with intravenous immunoglobulin (IVIG) and investigate whether the conjugate produce selective cytotoxicity on macrophages to provide a new strategy for the management of idiopathic thrombocytopenic purpura. MTX was bound to IVIG via human serum albumin as an intermediary. The binding activity of the F(c) fragment of the conjugate was assayed by flow cytometry. The selective cytotoxicity of the conjugate was determined by trypan blue exclusion. After conjugating, the binding activity of the conjugate to F(c) receptors did not diminish when compared with IVIG. In vitro, the conjugate showed significantly higher cytotoxicity to macrophages than Hela cells. The conjugate of IVIG and MTX showed potent and selective cytotoxicity to macrophages in vitro.

PMID: 18479295 [PubMed - in process]

(Source: International Journal of Laboratory Hematology)

Delayed decline of gamma-globin expression in infant age associated with the presence of (g)gamma-158 (c-->t) polymorphism.

International Journal of Laboratory Hematology — Fri, 16 May 2008 16:42:50 +0100

Delayed decline of gamma-globin expression in infant age associated with the presence of (G)gamma-158 (C-->T) polymorphism.

Int J Lab Hematol. 2008 Jun;30(3):191-195

Authors: Grosso M, Amendolara M, Rescigno G, Danise P, Todisco N, Izzo P, Amendola G

Persistent production of fetal hemoglobin (HbF) in adult has ameliorative effects on hemoglobinopathies and great efforts are currently made to achieve an exhaustive understanding of the molecular mechanisms of the switching in globin gene expression. One of the factors reported to be associated with the expression of fetal globin genes is the Xmn I (G)gamma-158 polymorphism, although it is still unclear if it is involved in this mechanism either by itself or in strong linkage disequilibrium with other loci. Here, we report a novel effect of the Xmn I (G)gamma-158 site that was found associated with a significant delayed decline of HbF production in infant age. The prolonged decay trend was enhanced when the (G)gamma-158 C-->T substitution was co-inherited with a beta-thalassemic trait. Our observations reinforce the hypothesis that this region plays an important role in the expression of the gamma-globin genes and give new insights on the intriguing and still poorly understood mechanisms of globin gene expression switching.

PMID: 18479296 [PubMed - as supplied by publisher]

(Source: International Journal of Laboratory Hematology)

Bio-maleimide as a generic stain for detection and quantitation of microparticles.

International Journal of Laboratory Hematology — Fri, 16 May 2008 16:42:47 +0100

Bio-maleimide as a generic stain for detection and quantitation of microparticles.

Int J Lab Hematol. 2008 Jun;30(3):196-9

Authors: Enjeti AK, Lincz L, Seldon M

Microparticles (MP) are small fragments of cytoplasm shed from a cell surface and their role in the pathophysiology of disease is being extensively investigated. A novel staining technique for quantifying total MP in peripheral blood was evaluated in this study. Evaluation of Bodipy-maleimide (or bio-maleimide) as a stain for quantifying total MP in peripheral blood by flow cytometry. Samples were obtained from 10 healthy donors after informed consent. Plasma was prepared by sequential centrifugation at 1500 g followed by 13 000 g and stained with Annexin V and bio-maleimide. Enumeration beads were added after 15 min of incubation with the stain and samples analyzed on a FACS Canto flow cytometer. Detection and quantification of MP by bio-maleimide staining was comparable with that by Annexin V. The total mean MP level with bio-maleimide staining was 34 +/- 19.7/mul (range of 11.6-68.1/mul) and with Annexin V staining it was 38.9 +/- 29.8/mul (range of 10.6 to 112.9/mul). There was no significant difference using a paired t-test and methods were comparable using a Bland-Altman plot. Bio-maleimide is a useful and inexpensive stain to measure total MP levels in peripheral blood by flow cytometry. This technique could be employed to study thrombotic risks in a variety of disease states.

PMID: 18479297 [PubMed - in process]

(Source: International Journal of Laboratory Hematology)

Comparison of an immuno-turbidometric method (stalia((r))d-di) with an established enzyme linked fluorescent assay (vidas((r))) d-dimer for the exclusion of venous thromboembolism.

International Journal of Laboratory Hematology — Fri, 16 May 2008 16:42:44 +0100

Comparison of an immuno-turbidometric method (STalia((R))d-DI) with an established enzyme linked fluorescent assay (VIDAS((R))) d-dimer for the exclusion of venous thromboembolism.

Int J Lab Hematol. 2008 Jun;30(3):200-4

Authors: Sukhu K, Beavis J, Baker PM, Keeling DM

The use of d-dimer tests for the exclusion of venous thromboembolism is an important advance in clinical practice and also has economic benefits. The Stalia((R))d-Di (Diagnostica Stago, Asnieres, France) is a semi automated system for the quantification of d-dimer using an immuno-turbidometric method incorporating a suspension of latex microparticles coated with two different monoclonal antibodies specifically targeted against human d-dimer fragments. Results are available rapidly in <10 min compared with 35 min for the established VIDAS((R))d-dimer automated enzyme-linked immunosorbent assay (ELISA, BioMerieux, Basingstoke, UK). During November and December 2005, 100 consecutive patients attending the outpatient deep venous thrombosis (DVT) clinic were tested using the VIDAS((R))d-dimer as part of the routine DVT investigation. Using the same samples, d-dimer estimation was also performed on the STalia((R))d-Di for comparison. Across a wide range of data (Vidas 83-5656) and (STalia((R)) <200->4000), there was good agreement between the two methods. Using cutoff's of 500 mug/l fibrinogen equivalent units (Keeling et al., 1999), 42% (42/100) patients were negative (<500) and 46% (46/100) were positive (>500) on both systems. Six per cent (6/100) were positive on the Vidas but negative on the STalia((R)) and another 6% (6/100) were positive on the STalia((R)) but negative on the Vidas. In conclusion, 88% (88/100) of patients showed agreement and in the other 12% (12/100), one had a DVT as identified by Compression ultrasonography (CUS). In this study, there were seven patients with a DVT as identified by CUS and they all scored as 'likely' on a pretest clinical probability score and so negative d-dimer would not be used clinically to rule out the disease. The Vidas is a well established instrument for d-dimer measurement in outpatient DVT clinics, and in this small study the STalia((R)) compares very well and therefore would fit into an outpatient setting for d-dimer measurement. But ideally a larger study would be required before implementing new methodology in a clinical setting.

PMID: 18479298 [PubMed - in process]

(Source: International Journal of Laboratory Hematology)

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Performance evaluation of bc-3200 hematology analyzer in a university hospital.

International Journal of Laboratory Hematology — Fri, 16 May 2008 16:42:42 +0100

Performance evaluation of BC-3200 hematology analyzer in a university hospital.

Int J Lab Hematol. 2008 Jun;30(3):205-13

Authors: Peng L, Bai L, Nie L, Wu Z, Yan C

The BC-3200 automated hematology analyzer was evaluated and compared with the Beckman-Coulter AcT (A(c).T diff 2) 3-part differential hematology analyzer. The BC-3200 was evaluated according to guidelines published by the International Committee for Standardization in Hematology (ICSH), Clinical and Laboratory Standards Institute (CLSI), and Department of Food and Drug Administration (FDA). The results demonstrated no background, minimal carryover (<0.5%), and excellent linearity for hemoglobin (Hb) level, white blood cell (WBC), red blood cell (RBC), and platelet (PLT) counts (>0.998). Precision was generally acceptable for all complete blood count (CBC) parameters; coefficients of variation (CVs) were within the manufacturer's claims and CVs of CBC parameters, including WBC, RBC and PLT counts, Hb and mean corpuscular volume, were <6%. Correlation between the BC-3200 and A(c).T diff 2 was excellent (r > 0.98) for all major CBC parameters (WBC, RBC, and PLT counts and Hb). We conclude that the overall performance of the BC-3200 is excellent and compares well with that of the Coulter A(c).T diff 2.

PMID: 18479299 [PubMed - in process]

(Source: International Journal of Laboratory Hematology)

Platelet size has diagnostic predictive value for bone marrow metastasis in patients with solid tumors.

International Journal of Laboratory Hematology — Fri, 16 May 2008 16:42:39 +0100

Platelet size has diagnostic predictive value for bone marrow metastasis in patients with solid tumors.

Int J Lab Hematol. 2008 Jun;30(3):214-9

Authors: Aksoy S, Kilickap S, Hayran M, Harputluoglu H, Koca E, Dede DS, Erman M, Turker A

Though not very common, solid tumor involvement of the bone marrow (BM) may have serious consequences. Recent studies have shown that mean platelet volume (MPV) is a good indicator for BM disease in the differential diagnosis of thrombocytopenia. We investigated the significance of MPV in the diagnosis of BM metastasis in patients with solid tumors. Patients with histologically-verified solid tumors for whom BM biopsy specimens were available (n = 121) and healthy controls (n = 62) were included in this retrospective study. A total of 183 individuals were analyzed. Of the patients, 61 had a diagnosis of BM metastasis (Group A), 60 did not have BM metastasis (Group B). Group B and C (healthy controls) constituted the control group without BM metastasis (n = 122). The mean MPV was 7.0 +/- 0.8 fl in patients with BM metastasis and 8.4 fl in the control group (P < 0.001). A cut-off point of <7.4 fl was found to have significant predictive value according to receiver-operating characteristics curve analysis. This cut-off point had 85% positive predictive value and 90% negative predictive value in the diagnosis of BM metastasis (odds ratio: 53; 95% confidence interval: 20-135), and a sensitivity of 82.7% and specificity of 89.6%. MPV can be used as a reliable marker to guide the clinician as to the likely presence or absence of BM metastasis in patients with solid tumors.

PMID: 18479300 [PubMed - in process]

(Source: International Journal of Laboratory Hematology)

The effects of thalidomide on chemotactic migration of multiple myeloma cell lines.

International Journal of Laboratory Hematology — Fri, 16 May 2008 16:42:36 +0100

The effects of thalidomide on chemotactic migration of multiple myeloma cell lines.

Int J Lab Hematol. 2008 Jun;30(3):220-9

Authors: Fuchida SI, Shimazaki C, Hirai H, Akamatsu S, Yamada N, Uchida R, Okano A, Okamoto M, Inaba T, Taniwaki M

We examined the effect of thalidomide and dexamethasone on the migration of multiple myeloma (MM) cell lines, U266, RPMI8226, and NCI-H929, using chemotaxis chamber plates. U266 underwent chemotactic migration in response to stromal-cell derived factor-1 alpha (SDF-1alpha), and other cell lines underwent random migration in response to SDF-1alpha or monocyte chemotactic protein-1 alpha. Following preincubation with 1 mug/ml thalidomide, the cell lines showed reduced migratory capacity in response to SDF-1alpha. Concerning the corresponding receptors, CXC chemokine receptor 4 was detected only on the surface of U266, by flow cytometry, whereas chemokine (C-C motif) receptor 2 was not detected on all three cell lines. Moreover, decreased migration by thalidomide was not accompanied by altered expression of the corresponding receptors of each cell line. This is the first report to show the effects of thalidomide on the migration of MM cell lines. The results suggest that the inhibition of chemotactic migration might be one of the mechanisms of the success of thalidomide in controlling MM.

PMID: 18479301 [PubMed - in process]

(Source: International Journal of Laboratory Hematology)

Correlation of serum il-6, il-8 and il-10 levels with clinicopathological features and prognosis in patients with diffuse large b-cell lymphoma.

International Journal of Laboratory Hematology — Fri, 16 May 2008 16:42:33 +0100

Correlation of serum IL-6, IL-8 and IL-10 levels with clinicopathological features and prognosis in patients with diffuse large B-cell lymphoma.

Int J Lab Hematol. 2008 Jun;30(3):230-9

Authors: Nacinović-Duletić A, Stifter S, Dvornik S, Skunca Z, Jonjić N

Cytokines play important roles in the pathogenesis of lymphomas. This study aimed to determine the relationship(s) between serum levels of interleukin (IL)-6, IL-8 and IL-10, measured by enzyme-immunoassay, and the clinical characteristics and outcomes in 46 untreated patients with diffuse large B-cell lymphoma (DLBCL). Serum IL-6, IL-8 and IL-10 levels were higher in DLBCL patients than in control subjects. Elevated levels of IL-6, IL-8 and IL-10 correlated with more adverse disease features. Consequently, patients with elevated IL-6, IL-8 and IL-10 levels prior to treatment had a lower response to therapy. Furthermore, those with elevated IL-6 and IL-10 levels had poor median, 3-year and 5-year survival, while elevated serum IL-8 level did not correlate with overall survival. Worse survival was also confirmed in patients with combined elevated pretreatment serum levels of IL-6, IL-8 and IL-10 (none, one, two or three elevated). Multivariate analysis identified elevated values of IL-6 and IL-10 and response to therapy as significant predictors for overall survival. Serum levels of IL-6, IL-8 and IL-10 before treatment of patients with newly diagnosed DLBCL may give some insight into the possible prognosis and thus facilitate the decisions regarding therapeutic approaches for individual patients.

PMID: 18479302 [PubMed - in process]

(Source: International Journal of Laboratory Hematology)

Single nucleotide polymorphisms in the apo(a) kringle iv type 8 domain are not associated with atherothrombotic serum lipoprotein (a) concentration, in a portuguese paediatric population.

International Journal of Laboratory Hematology — Fri, 16 May 2008 16:42:31 +0100

Single nucleotide polymorphisms in the apo(a) kringle IV type 8 domain are not associated with atherothrombotic serum lipoprotein (a) concentration, in a portuguese paediatric population.

Int J Lab Hematol. 2008 Jun;30(3):240-3

Authors: Ferreira H, Costa E, Vieira E, Barbot J, Dos Santos R

Lipoprotein (a) (Lp[a]) is a complex of apolipoprotein (a) (apo[a]) and low-density lipoprotein (LDL), associated with atherothrombotic disease. Most of the interindividual variations in plasma levels of Lp(a) can be attributed to sequence differences linked to the apo(a) gene locus. The aim of this study was to investigate a possible link between single nucleotide polymorphisms (SNPs) in the apo(a) kringle (K) IV type 8 domain and atherothrombotic serum Lp(a) concentrations. Direct sequencing of the two exons and flanking intronic sequences of the apo(a) K IV type 8 domain was performed in a group of 97 paediatric patients, 51 with serum Lp(a) concentration above and 46 with concentration below 30 mg/dl,. We found three SNPs, two in exon 1 (c.66A>C and c.133G>A) and one in intron 1 (c.160+1G>A). The c.66A>C polymorphism was the most common with a heterozygosity frequency of 15.46%. The c.133G>A and c.160+1G>A polymorphisms were found at a frequency of 5.15% and 1.03%, respectively. No statistically significant difference was found in the genotype distribution between the two groups of patients. Our results suggest that these SNPs in the apo(a) K IV 8 domain are not directly associated with atherothrombotic serum Lp(a) concentration in our population.

PMID: 18479303 [PubMed - in process]

(Source: International Journal of Laboratory Hematology)

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A case of paroxysmal nocturnal hemoglobinuria presenting with intra-abdominal bleeding due to splenic rupture, developing renal infarct.

International Journal of Laboratory Hematology — Fri, 16 May 2008 16:42:28 +0100

A case of paroxysmal nocturnal hemoglobinuria presenting with intra-abdominal bleeding due to splenic rupture, developing renal infarct.

Int J Lab Hematol. 2008 Jun;30(3):248-53

Authors: Uzun S, Alpay N, Ozturk GB, Saka B, Yenerel M, Erten N, Karan MA, Taşcioglu C

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare disorder characterized by intravascular hemolysis, hemoglobinuria, and thrombosis. Thrombotic attacks are life threatening and are responsible for nearly 50% of PNH-related deaths. Compared with thrombotic events, bleeding related to thrombocytopenia in PNH is quite rare. This report describes an atypical clinical presentation with problems in the diagnosis and management of a woman who presented with a splenic infarct followed by massive intra-abdominal bleeding due to splenic rupture. She also developed a renal infarct during hospitalization after diagnosis.

PMID: 18479304 [PubMed - in process]

(Source: International Journal of Laboratory Hematology)

Evaluation of morpho/immunological telehaematology file exchanges for the inclusion of patients with chronic lymphocytic leukaemia in a therapeutic trial.

International Journal of Laboratory Hematology — Fri, 16 May 2008 16:42:25 +0100

Evaluation of morpho/immunological telehaematology file exchanges for the inclusion of patients with chronic lymphocytic leukaemia in a therapeutic trial.

Int J Lab Hematol. 2008 Jun;30(3):256-8

Authors: Lesesve J, Palmiéri A, Brion A, Feugier P, Mahé B, Garand R

PMID: 18479305 [PubMed - in process]

(Source: International Journal of Laboratory Hematology)

Expression of zap-70 in patients with chronic lymphocytic leukemia may change significantly during the course of the disease.

International Journal of Laboratory Hematology — Fri, 16 May 2008 16:42:23 +0100

Expression of ZAP-70 in patients with chronic lymphocytic leukemia may change significantly during the course of the disease.

Int J Lab Hematol. 2008 Jun;30(3):259-60

Authors: Smolej L, Vroblova V, Novosad J

PMID: 18479306 [PubMed - in process]

(Source: International Journal of Laboratory Hematology)

New hope for uk follicular lymphoma patients as zevalin(r), [90y]-ibritumomab tiuxetan, licenced for first line consolidation therapy

Lymphoma / Leukemia News From Medical News Today — Fri, 16 May 2008 10:00:00 +0100

Zevalin ([90Y]-ibritumomab tiuxetan) can now be used as first-line consolidation therapy after remission induction in previously untreated patients with follicular lymphoma (FL). (Source: Lymphoma / Leukemia News From Medical News Today)

Effects of rosiglitazone on contralateral iliac artery after vascular injury in hypercholesterolemic rabbits.

Thrombosis Journal — Fri, 16 May 2008 04:00:00 +0100

Background: The objective was to evaluate the effects of rosiglitazone on iliac arteries of hypercholesterolemic rabbits undergoing balloon catheter injury in the contralateral iliac arteries. Methods: White male rabbits were fed a hypercholesterolemic diet for 6 weeks and divided into two groups as follows: rosiglitazone group, 14 rabbits treated with rosiglitazone (3 mg/Kg body weight/day) during 6 weeks; and control group, 18 rabbits without rosiglitazone treatment. All animals underwent balloon catheter injury of the right iliac artery on the fourteenth day of the experiment.Results: There was no significant difference in intima/media layer area ratio between the control group and the rosiglitazone group. Rosiglitazone did not reduce the probability of lesions types I, II, or III (72.73% vs. 92.31%; p=0.30) and types IV or V (27.27% vs. 7.69%; p=0.30). There were no differences in the extent of collagen type I and III deposition or in the percentage of animals with macrophages in the intima layer. The percentage of rabbits with smooth muscle cells in the intima layer was higher in rosiglitazone group (p=0.011).Conclusions: These findings demonstrate that rosiglitazone given for 6 weeks did not prevent atherogenesis at a vessel distant from the injury site. (Source: Thrombosis Journal)

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Pleural mesothelioma trial shows no benefit for chemo

MedPage Today Hematology/Oncology — Thu, 15 May 2008 22:30:00 +0100

LONDON, May 15 -- Adding chemotherapy to active symptom control in cases of malignant pleural mesothelioma appeared to have little effect in a large randomized trial, researchers here said. (Source: MedPage Today Hematology/Oncology)

A single-nucleotide polymorphism in the human itgb3 gene is associated with the platelet-specific alloantigen vaa (hpa-17bw) involved in fetal maternal alloimmune thrombocytopenia

Transfusion — Thu, 15 May 2008 18:48:23 +0100

Transfusion, Volume 0, Issue 0, Page ???, OnlineEarly Articles. BACKGROUND: The previously reported platelet (PLT)-specific antigen, Vaa, was defined by an alloantibody detected in the serum sample of a mother who delivered an infant displaying symptoms of severe fetal maternal alloimmune thrombocytopenia (FMAIT). ... (Source: Transfusion)

Fibrinogen gene variation and ischemic stroke

Journal of Thrombosis and Haemostasis — Thu, 15 May 2008 18:35:13 +0100

Journal of Thrombosis and Haemostasis, Volume 6, Issue 6, Page 897-904, June 2008. Summary. Background: Plasma fibrinogen level and fibrin clot structure are heritable traits that may be of importance in the pathogenesis of ischemic stroke. Objectives: To investigate associations between variation in the fibrinogen gamma (FGG), alpha (... (Source: Journal of Thrombosis and Haemostasis)

Prevalence and significance of vitamin d deficiency in multiple myeloma patients

British Journal of Haematology — Thu, 15 May 2008 18:09:08 +0100

British Journal of Haematology, Volume 0, Issue 0, Page ???, OnlineEarly Articles. (Source: British Journal of Haematology)

Protein c supports platelet binding and activation under flow: role of glycoprotein ib and apolipoprotein e receptor 2

Journal of Thrombosis and Haemostasis — Thu, 15 May 2008 15:54:27 +0100

Journal of Thrombosis and Haemostasis, Volume 6, Issue 6, Page 995-1002, June 2008. Summary. Background: Activated protein C (APC) regulates thrombin generation and inhibits apoptosis. Endothelial protein C receptor (EPCR)-bound protein C is activated by thrombomodulin-bound thrombin. APC inactivates coagulation factors (F)Va/VIIIa and ... (Source: Journal of Thrombosis and Haemostasis)

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A contribution to the debate on the laboratory criteria that define the antiphospholipid syndrome

Journal of Thrombosis and Haemostasis — Thu, 15 May 2008 15:54:07 +0100

Journal of Thrombosis and Haemostasis, Volume 6, Issue 6, Page 1048-1049, June 2008. (Source: Journal of Thrombosis and Haemostasis)

Tissue factor and il8 production by p-selectin-dependent platelet–monocyte aggregates in whole blood involves phosphorylation of lyn and is inhibited by il10

Journal of Thrombosis and Haemostasis — Thu, 15 May 2008 15:53:18 +0100

Journal of Thrombosis and Haemostasis, Volume 6, Issue 6, Page 986-994, June 2008. Summary. Background: P-selectin and CD40L expressed by activated platelets induce tissue factor (TF) and inflammatory cytokines in monocytes, but little is known of the cellular signaling pathways involved. The anti-inflammatory cytokine IL10 reduces ... (Source: Journal of Thrombosis and Haemostasis)

Join isth

Journal of Thrombosis and Haemostasis — Thu, 15 May 2008 15:53:17 +0100

Journal of Thrombosis and Haemostasis, Volume 6, Issue 6, Page 1057, June 2008. (Source: Journal of Thrombosis and Haemostasis)

Cytoprotective effect of activated protein c: specificity of par-1 signaling

Journal of Thrombosis and Haemostasis — Thu, 15 May 2008 15:52:57 +0100

Journal of Thrombosis and Haemostasis, Volume 6, Issue 6, Page 951-953, June 2008. (Source: Journal of Thrombosis and Haemostasis)

Ante- and postnatal risk factors of venous thrombosis: a hospital-based case–control study

Journal of Thrombosis and Haemostasis — Thu, 15 May 2008 15:52:30 +0100

Journal of Thrombosis and Haemostasis, Volume 6, Issue 6, Page 905-912, June 2008. Summary. Objective: To study ante- and postnatal risk factors of venous thrombosis (VT) in pregnancy. Methods: A hospital-based case–control study. Cases were women with objectively verified VT during pregnancy or postpartum. Two controls were selected ... (Source: Journal of Thrombosis and Haemostasis)

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Protease activated receptor 1 activation of platelet is associated with an increase in protein kinase ck2 activity

Journal of Thrombosis and Haemostasis — Thu, 15 May 2008 15:52:13 +0100

Journal of Thrombosis and Haemostasis, Volume 6, Issue 6, Page 1046-1048, June 2008. (Source: Journal of Thrombosis and Haemostasis)

Circulating endothelial cells in health and disease: how do we best quantify them?

Journal of Thrombosis and Haemostasis — Thu, 15 May 2008 15:51:52 +0100

Journal of Thrombosis and Haemostasis, Volume 6, Issue 6, Page 1021-1024, June 2008. (Source: Journal of Thrombosis and Haemostasis)

Ex vivo inhibition of thrombus formation by an anti-glycoprotein vi fab fragment in non-human primates without modification of glycoprotein vi expression

Journal of Thrombosis and Haemostasis — Thu, 15 May 2008 15:51:36 +0100

Journal of Thrombosis and Haemostasis, Volume 6, Issue 6, Page 1003-1011, June 2008. Summary. Objectives: Glycoprotein (GP)VI is an attractive target for the development of new antithrombotic drugs. Its deficiency protects animals in several models of thrombosis, arterial stenosis and ischemia-–reperfusion while inducing no major bleeding ... (Source: Journal of Thrombosis and Haemostasis)

Hemostatic effect of recombinant factor viia, nn1731 and recombinant factor viii on needle-induced joint bleeding in hemophilia a mice

Journal of Thrombosis and Haemostasis — Thu, 15 May 2008 15:51:11 +0100

Journal of Thrombosis and Haemostasis, Volume 6, Issue 6, Page 969-975, June 2008. Summary. Background: Hemophilia A is the most common serious bleeding disorder, and the hallmark of this disease is joint bleeding episodes. These result in hemophilic synovitis, an inflammatory and proliferative condition of the joint, which progresses ... (Source: Journal of Thrombosis and Haemostasis)

The src requirement for washed platelet aggregation and dense granule secretion in response to stimulation by a low level γ-thrombin

Journal of Thrombosis and Haemostasis — Thu, 15 May 2008 15:51:09 +0100

Journal of Thrombosis and Haemostasis, Volume 6, Issue 6, Page 1035-1037, June 2008. (Source: Journal of Thrombosis and Haemostasis)

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Lower factor xii activity is a risk marker rather than a risk factor for cardiovascular disease: a rebuttal

Journal of Thrombosis and Haemostasis — Thu, 15 May 2008 15:50:52 +0100

Journal of Thrombosis and Haemostasis, Volume 6, Issue 6, Page 1053-1054, June 2008. (Source: Journal of Thrombosis and Haemostasis)

Continuation of the international standard thromboplastin (human, recombinant, plain) by means of a replacement reconstitution fluid

Journal of Thrombosis and Haemostasis — Thu, 15 May 2008 15:50:34 +0100

Journal of Thrombosis and Haemostasis, Volume 6, Issue 6, Page 1042-1043, June 2008. (Source: Journal of Thrombosis and Haemostasis)

Protein s enhances the tissue factor pathway inhibitor inhibition of factor xa but not its inhibition of factor viia–tissue factor

Journal of Thrombosis and Haemostasis — Thu, 15 May 2008 15:50:19 +0100

Journal of Thrombosis and Haemostasis, Volume 6, Issue 6, Page 1044-1046, June 2008. (Source: Journal of Thrombosis and Haemostasis)

The importance of anticoagulant agents in measuring platelet aggregation in patients treated with clopidogrel and aspirin

Journal of Thrombosis and Haemostasis — Thu, 15 May 2008 15:50:03 +0100

Journal of Thrombosis and Haemostasis, Volume 6, Issue 6, Page 1040-1042, June 2008. (Source: Journal of Thrombosis and Haemostasis)

An international multicenter randomized study of computer-assisted oral anticoagulant dosage vs. medical staff dosage

Journal of Thrombosis and Haemostasis — Thu, 15 May 2008 15:50:01 +0100

Journal of Thrombosis and Haemostasis, Volume 6, Issue 6, Page 935-943, June 2008. Summary. Background: Increased demand for oral anticoagulants is overwhelming facilities worldwide, resulting in increasing use of computer assistance. A multicenter clinical endpoint study has been performed to compare the safety and effectiveness of ... (Source: Journal of Thrombosis and Haemostasis)

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Microparticle-mediated thrombin generation assay: increased activity in patients with recurrent thrombosis

Journal of Thrombosis and Haemostasis — Thu, 15 May 2008 15:49:13 +0100

Journal of Thrombosis and Haemostasis, Volume 6, Issue 6, Page 913-919, June 2008. Summary. Background: Circulating cell-derived microparticles (MP) are important players in thrombogenesis, attributed in part to tissue factor (TF) carried on them. We developed MP-mediated thrombin generation assay (TGA) and measured a series of patients ... (Source: Journal of Thrombosis and Haemostasis)

A first-in-human phase i trial of locally delivered human plasmin for hemodialysis graft occlusion

Journal of Thrombosis and Haemostasis — Thu, 15 May 2008 15:48:58 +0100

Journal of Thrombosis and Haemostasis, Volume 6, Issue 6, Page 944-950, June 2008. Summary. Background: Hemodialysis (HD) grafts often fail because of stenosis at the venous anastomosis and thrombotic occlusion. Percutaneous management relies on thrombolysis with plasminogen activators, mechanical removal of thrombus, and angioplasty of ... (Source: Journal of Thrombosis and Haemostasis)

Differential impact of conventional-dose and low-dose postmenopausal hormone therapy, tibolone and raloxifene on c-reactive protein and other inflammatory markers

Journal of Thrombosis and Haemostasis — Thu, 15 May 2008 15:48:38 +0100

Journal of Thrombosis and Haemostasis, Volume 6, Issue 6, Page 928-934, June 2008. Summary. Background: Postmenopausal hormone therapy (HT) is associated with an increased risk for arterial and venous thrombosis. Objectives: To compare the impact of HT, tibolone, and raloxifene on C-reactive protein (CRP) and other inflammatory markers, ... (Source: Journal of Thrombosis and Haemostasis)

Non-invasive viral gene transfer of factor ix to colonic epithelial cells in hemophilia b mice

Journal of Thrombosis and Haemostasis — Thu, 15 May 2008 15:48:22 +0100

Journal of Thrombosis and Haemostasis, Volume 6, Issue 6, Page 1033-1035, June 2008. (Source: Journal of Thrombosis and Haemostasis)

Lipid raft localization regulates the cleavage specificity of protease activated receptor 1 in endothelial cells

Journal of Thrombosis and Haemostasis — Thu, 15 May 2008 15:47:58 +0100

Journal of Thrombosis and Haemostasis, Volume 6, Issue 6, Page 954-961, June 2008. Summary. Background: The endothelial protein C receptor (EPCR)-dependent cleavage of protease activated receptor 1 (PAR-1) by either activated protein C (APC) or thrombin in lipid rafts initiates protective signaling responses in endothelial cells. ... (Source: Journal of Thrombosis and Haemostasis)

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Comparison of the capacities of two prothrombin complex concentrates to restore thrombin generation in plasma from orally anticoagulated patients: an in vitro study

Journal of Thrombosis and Haemostasis — Thu, 15 May 2008 15:47:33 +0100

Journal of Thrombosis and Haemostasis, Volume 6, Issue 6, Page 962-968, June 2008. Summary. Background: Human prothrombin complex concentrates (PCCs) are used for prevention and treatment of bleeding episodes in patients under warfarin therapy. PCCs contain human factor (F) II, FVII, FIX, FX, protein C and protein S. The concentrations ... (Source: Journal of Thrombosis and Haemostasis)

Globular adiponectin induces platelet activation through the collagen receptor gpvi-fc receptor γ chain complex

Journal of Thrombosis and Haemostasis — Thu, 15 May 2008 15:47:17 +0100

Journal of Thrombosis and Haemostasis, Volume 6, Issue 6, Page 1012-1020, June 2008. Summary. Background: The adipocyte-derived cytokine, adiponectin (Ad), exerts potent vascular effects, although the direct effects of Ad on blood platelets are unclear. Objective: The influence of globular Ad (gAd) on blood platelet function was ... (Source: Journal of Thrombosis and Haemostasis)

P-selectin polymorphisms’ influences on p-selectin serum concentrations and on their familial correlation: the stanislas family study

Journal of Thrombosis and Haemostasis — Thu, 15 May 2008 15:47:01 +0100

Journal of Thrombosis and Haemostasis, Volume 6, Issue 6, Page 920-927, June 2008. Summary. Background: P-selectin is an adhesion molecule known to be involved in the pathogenesis of several diseases through its major role in the initial phase of leukocytes recruitment during inflammation. However, genetic characterization of soluble P-... (Source: Journal of Thrombosis and Haemostasis)

Acquired von willebrand disease: potential contribution of the von willebrand factor collagen-binding to the identification of functionally inhibiting auto-antibodies to von willebrand factor: a rebuttal

Journal of Thrombosis and Haemostasis — Thu, 15 May 2008 15:46:43 +0100

Journal of Thrombosis and Haemostasis, Volume 6, Issue 6, Page 1051-1052, June 2008. (Source: Journal of Thrombosis and Haemostasis)