MedWorm: Infectious Diseases

All Fatal Ukraine H1N1 Cases at GISAID Have RBD D225G

Recombinomics — Fri, 20 Nov 2009 14:25:24 +0100

The commentary discusses the associated of receptor binding domain change D225G with fatal H1N1 cases in Ukraine. A map of the outbreak is linked. (11/19/09 14:17) (Source: Recombinomics)

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Media Myths Cloud Joint Hearings on Pandemic Vaccine

Recombinomics — Fri, 20 Nov 2009 14:25:24 +0100

The commentary discusses the impact of media myths on joint hearings on pandemic vaccine shortfalls. (11/19/09 17:17) (Source: Recombinomics)

D225G Lung Tropism Driving H1N1 False Negatives?

Recombinomics — Fri, 20 Nov 2009 14:25:24 +0100

The commentary discusses D225G lung tropism and potential for generating false negatives. (11/19/9 21:17) (Source: Recombinomics)

Ukraine Dead Increase to 354 - Fatal H1N1 Cases Have D225G

Recombinomics — Fri, 20 Nov 2009 14:25:24 +0100

The commentary discusses the increase in fatalities in Ukraine and the association of receptor binding domain change D225G with the fatal cases. A map of the outbreaks is linked. (11/20/09 13:38) (Source: Recombinomics)

Uganda: HIV-Positive Women Need Family Planning Services, Study Shows

AllAfrica News: HIV-Aids and STDs — Fri, 20 Nov 2009 12:43:24 +0100

HIV-positive women in western Uganda want fewer children than women not living with the virus, but often do not have access to family planning services, a new study reveals. (Source: AllAfrica News: HIV-Aids and STDs)

Gordon Brown gives World AIDS Day message

Terrence Higgins Trust — Fri, 20 Nov 2009 12:37:22 +0100

The Prime Minister, Gordon Brown has recorded a message to mark World AIDS Day, which is on December 1st. You can watch it hereLisa Power, Head of Policy at Terrence Higgins Trust said “We’re delighted that Gordon Brown is making a commitment to increase HIV testing. Thousands of people in the UK don’t know they have the virus and many find out very late – sometimes years after infection. We have to get more people taking a test, it’s quicker and easier than ever and it saves lives.”The video message also appears on the World AIDS Day website at www.worldAIDSday.org (Source: Terrence Higgins Trust)

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Routine Screening for Depression: Identifying a Challenge for Successful HIV Care

AIDS Patient Care and STDs — Fri, 20 Nov 2009 12:18:33 +0100

AIDS Patient Care and STDs Nov 2009, Vol. 23, No. 11: 949-955. (Source: AIDS Patient Care and STDs)

Antiviral Briefs

AIDS Patient Care and STDs — Fri, 20 Nov 2009 12:15:35 +0100

AIDS Patient Care and STDs Nov 2009, Vol. 23, No. 11: 987-989. (Source: AIDS Patient Care and STDs)

HIV/AIDS and STD Updates

AIDS Patient Care and STDs — Fri, 20 Nov 2009 12:15:33 +0100

AIDS Patient Care and STDs Nov 2009, Vol. 23, No. 11: 991-992. (Source: AIDS Patient Care and STDs)

Goosby Says PEPFAR Remains Among 'Highest Priorities' Of Obama Administration, Welcomes Partnership With South African President Zuma

HIV / AIDS News From Medical News Today — Fri, 20 Nov 2009 11:00:00 +0100

Eric Goosby, head of PEPFAR, on Wednesday reemphasized the U.S. commitment to fighting HIV/AIDS globally, the Associated Press reports. (Source: HIV / AIDS News From Medical News Today)

Terrence Higgins Trust gets Oxford involved in World AIDS Day

Terrence Higgins Trust — Fri, 20 Nov 2009 09:35:03 +0100

HIV and sexual health charity Terrence Higgins Trust (THT) is calling for people in Oxford to get involved in World AIDS Day (December 1) this year, either by attending an event, making a donation to support local HIV services, or wearing a red ribbon to raise awareness.World AIDS Day, which has been running every December since 1988, is dedicated to raising awareness of HIV and AIDS. In the UK alone, over 80,000 people are living with HIV and over 7,000 are diagnosed every year.The following events are taking place in Oxford for World AIDS Day:Monday 30 November (7.00am - 9.00am): Street collection, Oxford train stationStaff and volunteers from THT will be out in force during the morning rush hour at Oxford train station, raising awareness of HIV, giving out red ribbons and asking for don...

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Pandemic (H1N1) 2009 - update 75

WHO Swine Flu — Fri, 20 Nov 2009 09:00:00 +0100

As of 15 November 2009, worldwide more than 206 countries and overseas territories or communities have reported laboratory confirmed cases of pandemic influenza H1N1 2009, including over 6750 deaths. (Source: WHO Swine Flu)

Avian influenza - situation in Egypt - update 24

WHO Disease Outbreaks — Fri, 20 Nov 2009 09:00:00 +0100

The Ministry of Health of Egypt has reported a new confirmed human case of avian influenza A(H5N1). (Source: WHO Disease Outbreaks)

Nigeria: N.9 Million Locals Need HIV/Aids Drugs - NACA Boss

AllAfrica News: HIV-Aids and STDs — Fri, 20 Nov 2009 08:14:14 +0100

OVER 900,000 Nigerians suffering from the dreaded HIV/AIDS are in dire need of regular supply of antiretroviral drugs, the National Action Committee Against Aids (NACA), has said. (Source: AllAfrica News: HIV-Aids and STDs)

Pew Health Group Statement On Senate Mark Up Of The FDA Food Safety Modernization Act (S. 510)

Infectious Diseases / Bacteria / Viruses News From Medical News Today — Fri, 20 Nov 2009 08:00:00 +0100

Sandra Eskin, director of the Pew Health Group's Food Safety Campaign, has issued the following statement regarding the markup of the FDA Food Safety Modernization Act by the Senate Health, Education, Labor, & Pensions Committee: "The Pew Health Group applauds the members of the Senate Health, Education, Labor, & Pensions (HELP) Committee for approving the FDA Food Safety Modernization Act (S. 510) today. (Source: Infectious Diseases / Bacteria / Viruses News From Medical News Today)

How Viruses Destroy Bacteria

Infectious Diseases / Bacteria / Viruses News From Medical News Today — Fri, 20 Nov 2009 08:00:00 +0100

Viruses are well known for attacking humans and animals, but some viruses instead attack bacteria. Texas A&M University researchers are exploring how hungry viruses, armed with transformer-like weapons, attack bacteria, which may aid in the treatment of bacterial infections. The Texas A&M researchers' work is published in the renowned journal Nature Structural & Molecular Biology. The attackers are called phages, or bacteriophages, meaning eaters of bacteria. (Source: Infectious Diseases / Bacteria / Viruses News From Medical News Today)

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Southern Africa: SADC Aids Fiesta Set for Malawi

AllAfrica News: HIV-Aids and STDs — Fri, 20 Nov 2009 06:51:08 +0100

The second edition of Sadc Artists Aids Festival is scheduled for Lilongwe in Malawi starting on November 30 until December 6, 2009. (Source: AllAfrica News: HIV-Aids and STDs)

Update: Peramivir IV Fact Sheet for Health Care Providers (PDF)

CDC Swine Flu Updates — Fri, 20 Nov 2009 05:14:00 +0100

Revised documents to reflect new peramivir IV renal dosing and administration recommendations, authorized by FDA on November 19, 2009. (Source: CDC Swine Flu Updates)

Update: FDA-Issued Peramivir IV EUA Letter (PDF)

CDC Swine Flu Updates — Fri, 20 Nov 2009 05:12:00 +0100

Revised documents to reflect new peramivir IV renal dosing and administration recommendations, authorized by FDA on November 19, 2009. (Source: CDC Swine Flu Updates)

The risks of malaria infection in Kenya in 2009

BMC Infectious Diseases — Fri, 20 Nov 2009 00:00:00 +0100

Conclusion: Model based geo-statistical methods can be used to interpolate malaria risks in Kenya with precision and our model shows that the majority of Kenyans live in areas of very low P. falciparum risk. As malaria interventions go to scale effectively tracking epidemiological changes of risk demands a rigorous effort to document infection prevalence in time and space to remodel risks and redefine intervention priorities over the next 10-15 years. (Source: BMC Infectious Diseases)

New: Updated Guidance for the Use of CSL 2009 H1N1 Monovalent Vaccine

CDC Swine Flu Updates — Thu, 19 Nov 2009 19:15:00 +0100

On November 11, 2009, the FDA expanded the approved use of CSL’s™ seasonal and 2009 H1N1 monovalent influenza vaccines to include children aged 6 months and older. Both vaccines had previously been approved only for use in adults, aged 18 years and older. (Source: CDC Swine Flu Updates)

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Africa: HIV/Aids - U.S. Increases Funding in Continent

AllAfrica News: HIV-Aids and STDs — Thu, 19 Nov 2009 19:07:46 +0100

The United State's President's Emergency Plan For AIDS Relief (PEPFAR) has increased funding for HIV/AIDS in Africa from $2.3 billion in 2004 to $6.6 billion in 2009. (Source: AllAfrica News: HIV-Aids and STDs)

Millions of healthy children to be given swine flu jab

The Telegraph : Swine Flu A H1N1 — Thu, 19 Nov 2009 17:16:18 +0100

Three million children under five are to vaccinated against swine flu after a dramatic rise in serious cases in youngsters. (Source: The Telegraph : Swine Flu A H1N1)

South Africa: The Shameless Rian Malan

AllAfrica News: HIV-Aids and STDs — Thu, 19 Nov 2009 17:03:21 +0100

In 2001, Rian Malan wrote an article in Rolling Stone questioning the accuracy of HIV tests in order to disparage the evidence of a growing HIV epidemic in South Africa. In 2003 he published similar articles in the Spectator and Noseweek. All these articles were replete with errors. I subsequently debunked the latter two in a January 2004 article. (Source: AllAfrica News: HIV-Aids and STDs)

Africa: Consequences of Less Funding for Aids - Living With Aids # 413

AllAfrica News: HIV-Aids and STDs — Thu, 19 Nov 2009 17:03:21 +0100

Thanks to the international recession, donors are either decreasing or opting not to increase their funding of AIDS treatment. This will have devastating effects on poorer countries that are largely dependent on foreign aid. (Source: AllAfrica News: HIV-Aids and STDs)

European Antibiotic Awareness Day

Infectious Diseases / Bacteria / Viruses News From Medical News Today — Thu, 19 Nov 2009 15:00:00 +0100

Yesterday (18th November 2009) marks the second annual European Antibiotic Awareness Day, established to highlight the problem of increasing antibiotic resistance and the need for prudent use of antibiotics. Figures from the European Surveillance of Antimicrobial Consumption project, which monitors antibiotic use and antimicrobial resistance in countries across Europe, suggest that antibiotic use in many countries remains too high. (Source: Infectious Diseases / Bacteria / Viruses News From Medical News Today)

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Terrence Higgins Trust gets Wolverhampton involved in World AIDS Day

Terrence Higgins Trust — Thu, 19 Nov 2009 14:57:15 +0100

HIV and sexual health charity, Terrence Higgins Trust (THT) is calling for people in Wolverhampton to get involved in World AIDS Day (December 1) this year, either by attending an event, making a donation to support local HIV services, or wearing a red ribbon to raise awareness.World AIDS Day, which has been running every December since 1988, is dedicated to raising awareness of HIV and AIDS. In the UK alone, over 80,000 people are living with HIV and over 7,000 are diagnosed every year.The following events are taking place in Wolverhampton for World AIDS Day:Saturday 28 November (11.00am - 3.00pm): Awareness Drive, The Mander CentreTHT staff and volunteers will be out in force at the Mander Centre all day, raising awareness of HIV, asking for donations and giving out red ribbons. They wil...

Terrence Higgins Trust gets Shropshire, Telford & Wrekin involved in World AIDS Day

Terrence Higgins Trust — Thu, 19 Nov 2009 14:52:36 +0100

HIV and sexual health charity Terrence Higgins Trust (THT) is calling for people across Shropshire, Telford & Wrekin to get involved in World AIDS Day (December 1) this year, either by attending an event, making a donation to support local HIV services, or wearing a red ribbon to raise awareness.World AIDS Day, which has been running every December since 1988, is dedicated to raising awareness of HIV and AIDS. In the UK alone, over 80,000 people are living with HIV and over 7,000 are diagnosed every year.The following events, run in collaboration with Shropshire Buddies & Body Positive, are taking place in Shropshire, Telford & Wrekin for World AIDS Day:County-wide Awareness Drive (various times and locations across Shropshire)Friday 27 November (10.00am - 2.00pm): Newport High...

Terrence Higgins Trust gets Swindon involved in World AIDS Day

Terrence Higgins Trust — Thu, 19 Nov 2009 14:48:51 +0100

HIV and sexual health charity, Terrence Higgins Trust (THT) is calling for people in Swindon to get involved in World AIDS Day (December 1) this year, either by attending an event, making a donation to support local HIV services, or wearing a red ribbon to raise awareness.World AIDS Day, which has been running every December since 1988, is dedicated to raising awareness of HIV and AIDS. In the UK alone, over 80,000 people are living with HIV and over 7,000 are diagnosed every year.Steve Jones, Regional Manager for THT in the South West, said: “World AIDS Day is one of the most important events in THT’s calendar. Currently in the UK one in four people with HIV don't know they have it, so it's vital that we continue to raise awareness. We hope local people will get involved in some way, ...

Healthy children below age of five to get swine flu jab

The Telegraph : Swine Flu A H1N1 — Thu, 19 Nov 2009 14:42:27 +0100

Government announces that the vaccination programme is to be rolled out to all children under five as it emerges that an 11yearold girl who had the H1N1 virus has died. (Source: The Telegraph : Swine Flu A H1N1)

Terrence Higgins Trust Cymru gets Swansea and Bridgend involved in World AIDS Day

Terrence Higgins Trust — Thu, 19 Nov 2009 14:40:36 +0100

HIV and sexual health charity, Terrence Higgins Trust Cymru (THT Cymru) is calling for people in Swansea and Bridgend to get involved in World AIDS Day (December 1) this year, either by attending an event, making a donation to support local HIV services, or wearing a red ribbon to raise awareness.World AIDS Day, which has been running every December since 1988, is dedicated to raising awareness of the condition. In the UK alone, around 80,000 people are living with HIV and over 7,500 are diagnosed every year.The following events are taking place in Swansea and Bridgend for World AIDS Day:Friday 4 December (8.00pm - late): Cabaret Fundraiser, ChampersTo mark World AIDS Day, gay venue Champers (210 High Street, Swansea) will hold a not to be missed evening of music and cabaret from local per...

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Terrence Higgins Trust gets Sandwell involved in World AIDS Day

Terrence Higgins Trust — Thu, 19 Nov 2009 14:35:11 +0100

HIV and sexual health charity, Terrence Higgins Trust (THT) is calling for people in Sandwell to get involved in World AIDS Day (December 1) this year, either by attending an event, making a donation to support local HIV services, or wearing a red ribbon to raise awareness.World AIDS Day, which has been running every December since 1988, is dedicated to raising awareness of HIV and AIDS. In the UK alone, over 80,000 people are living with HIV and over 7,000 are diagnosed every year.The following events are taking place in Sandwell for World AIDS Day this year:Saturday 21 November (3.00pm - 6.00pm): Open forum on HIV for English-speaking AfricansAt THT’s Sandwell centre (290-292 High Street), there will be a special session for English-speaking Africans living locally, providing basic fac...

RBD D225G in China and Australia Raise Ukraine Concerns

Recombinomics — Thu, 19 Nov 2009 14:31:14 +0100

The commentary discusses appearance of the receptor binding domain change, D225G, on multiple pandemic H1N1 backgrounds, including those in China and Australia. A map of locations in China is linked. (11/18/09 14:41) (Source: Recombinomics)

Receptor Binding Domain Change D225G Confirmed in Ukraine

Recombinomics — Thu, 19 Nov 2009 14:31:14 +0100

The commentary discusses confirmation of receptor binding domain change D225G in lung samples from Ukraine. (11/18/09 18:35) (Source: Recombinomics)

RBD Change D225G in Ukraine Lung Raises Concerns

Recombinomics — Thu, 19 Nov 2009 14:31:14 +0100

The commentary discusses associate of receptor binding domain change D225G with lung samples in Ukraine. (11/18/09 21:55) (Source: Recombinomics)

Ukraine Dead Increase to 344 - Sequences Released

Recombinomics — Thu, 19 Nov 2009 14:31:14 +0100

The commentary discusses the increase in H1N1 fatalities in Ukraine to 344. A map of the outbreak is linked. (11/18/09 22:45) (Source: Recombinomics)

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Terrence Higgins Trust gets Gloucester involved in World AIDS Day

Terrence Higgins Trust — Thu, 19 Nov 2009 14:30:39 +0100

HIV and sexual health charity, Terrence Higgins Trust (THT) is calling for people in Gloucester to get involved in World AIDS Day (December 1) this year, either by attending an event, making a donation to support local HIV services, or wearing a red ribbon to raise awareness.World AIDS Day, which has been running every December since 1988, is dedicated to raising awareness of HIV and AIDS. In the UK alone, over 80,000 people are living with HIV and over 7,000 are diagnosed every year.In the run up to World AIDS Day this year, THT in Gloucester will be having an awareness drive by providing information on HIV and AIDS on posters in Gloucester’s Shire Hall and in every library and mobile library across Gloucestershire.On 1 December itself, THT staff and volunteers will be out in force at t...

Terrence Higgins Trust gets Bristol involved in World AIDS Day

Terrence Higgins Trust — Thu, 19 Nov 2009 14:13:39 +0100

HIV and sexual health charity Terrence Higgins Trust (THT) is calling for people in Bristol to get involved in World AIDS Day (December 1) this year, either by attending an event, making a donation to support local HIV services, or wearing a red ribbon to raise awareness.World AIDS Day, which has been running every December since 1988, is dedicated to raising awareness of HIV and AIDS. In the UK alone, over 80,000 people are living with HIV and over 7,000 are diagnosed every year.The following events are taking place in Bristol for World AIDS Day:From Monday 31 November: Flying the flag for World AIDS DayBristol City Council and THT will mark World AIDS Day by raising a special flag above the Council House for one week from 31 November. The flag shows a red ribbon against a white backgroun...

Healthy children below age of five to get swine flu jab

The Telegraph : Swine Flu A H1N1 — Thu, 19 Nov 2009 14:06:29 +0100

The swine flu vaccination programme is to be rolled out to children under five with no underlying health problems the Government is to announce. (Source: The Telegraph : Swine Flu A H1N1)

Swine flu: Home Office in talks with coffin manufacturers about increasing production

The Telegraph : Swine Flu A H1N1 — Thu, 19 Nov 2009 13:16:02 +0100

The Home Office has held talks with coffin manufacturers about increasing production if deaths from swine flu rise. (Source: The Telegraph : Swine Flu A H1N1)

Giant Microbes: Soft toy versions of bacteria and viruses such as HIV Herpes Swine Flu and Ebola

The Telegraph : Swine Flu A H1N1 — Thu, 19 Nov 2009 13:09:17 +0100

Soft toy versions of bacteria and viruses like Swine Flu and Ebola. (Source: The Telegraph : Swine Flu A H1N1)

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Africa: World Cup to Help Create HIV Awareness

AllAfrica News: HIV-Aids and STDs — Thu, 19 Nov 2009 12:31:06 +0100

In less than seven months South Africa will host the world's biggest single sporting event - the FIFA World Cup. The chance to reach millions of local and visiting football fans presents a golden opportunity, not only for the country's business and tourism sectors, but also for its efforts to combat HIV/AIDS. (Source: AllAfrica News: HIV-Aids and STDs)

Nigeria: U.S., FG Partner On Fight Against HIV/Aids

AllAfrica News: HIV-Aids and STDs — Thu, 19 Nov 2009 11:20:35 +0100

As the 2009 World AIDS Day with theme; "Universal Access and Human Right, approaches, the United States of America is erpected to partner Nigeria and other development partners in the fight against HIV/AIDS. (Source: AllAfrica News: HIV-Aids and STDs)

School-based H1N1 Influenza Clinics To Begin For K-3 Students, Alabama

Infectious Diseases / Bacteria / Viruses News From Medical News Today — Thu, 19 Nov 2009 11:00:00 +0100

The Alabama Department of Public Health will begin offering nasal mist flu vaccine to kindergarten through third grade students in Alabama schools at voluntary H1N1 influenza vaccination clinics. A few clinics will begin the week of Nov. 23, but the majority will be held beginning the week of Nov. 30-Dec. 5. "Vaccination is the best way to protect your children from this potentially serious disease," said State Health Officer Dr. Donald Williamson. (Source: Infectious Diseases / Bacteria / Viruses News From Medical News Today)

Don't Let The Flu Ruin Your Holiday

Infectious Diseases / Bacteria / Viruses News From Medical News Today — Thu, 19 Nov 2009 11:00:00 +0100

With H1N1 flu causing illness all across the country, the American Red Cross has some steps to take that will lessen the chances of getting sick over the long Thanksgiving holiday weekend. "Thanksgiving is a time to enjoy being with family, not to be in bed with the flu," said Sharon Stanley, chief nurse of the American Red Cross. "You can follow easy tips to try and avoid becoming ill over the upcoming holiday. (Source: Infectious Diseases / Bacteria / Viruses News From Medical News Today)

Groups At High Risk Of H1N1 Influenza A Should Avoid Travelling To 2009 HAJJ

Infectious Diseases / Bacteria / Viruses News From Medical News Today — Thu, 19 Nov 2009 10:00:00 +0100

Some 2.5 million pilgrims are expected at holy sites in Saudi Arabia for the 2009 Hajj, expected to begin around November 25. To combat the threat posed by H1N1 influenza A, the Saudi Arabian Health Ministry has issued public health recommendations, including recommending groups at highest risk of contracting H1N1 postpone their pilgrimage to a later year when the threat is reduced. (Source: Infectious Diseases / Bacteria / Viruses News From Medical News Today)

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Sangamo BioSciences Provides Update On Phase 1 Safety Trial Of SB-728-T For HIV/AIDS

HIV / AIDS News From Medical News Today — Thu, 19 Nov 2009 10:00:00 +0100

Sangamo BioSciences, Inc. (Nasdaq: SGMO) announced that data from the University of Pennsylvania investigator sponsored Phase 1 safety study of Sangamo's zinc finger nuclease (ZFN) based product, SB-728-T, for HIV/AIDS were inadvertently and prematurely disclosed on the internet. (Source: HIV / AIDS News From Medical News Today)

Nigeria: PATA's Training Mainstreams Gender Into HIV Response

AllAfrica News: HIV-Aids and STDs — Thu, 19 Nov 2009 09:26:38 +0100

POSITIVE Action for Treatment Access (PATA), a non government organization has commenced a 12-month Women Leadershish and Mentorship Training (WLMT) on HIV Treatment Education Fellowship to enable the organization achieve unmet treatment need among women living with HIV. (Source: AllAfrica News: HIV-Aids and STDs)

South Africa: Should Mbeki be Prosecuted Over Aids Deaths?

AllAfrica News: HIV-Aids and STDs — Thu, 19 Nov 2009 09:01:17 +0100

THE Young Communist League (YCL) yesterday repeated its call that former president Thabo Mbeki be prosecuted for AIDS-related deaths, saying it sided with victims rather than critics of the proposed court action, including the African National Congress (ANC) Youth League. (Source: AllAfrica News: HIV-Aids and STDs)

Safety of pandemic vaccines

WHO Swine Flu — Thu, 19 Nov 2009 09:00:00 +0100

To date, WHO has received vaccination information from 16 of around 40 countries conducting national H1N1 pandemic vaccine campaigns. Based on information in these 16 countries, WHO estimates that around 80 million doses of pandemic vaccine have been distributed and around 65 million people have been vaccinated. National immunization campaigns began in Australia and the People’s Republic of China in late September. (Source: WHO Swine Flu)

Anacor Initiates Phase I Clinical Development For AN3365 - A Novel Antibiotic For The Treatment Of Gram-Negative Infections

Infectious Diseases / Bacteria / Viruses News From Medical News Today — Thu, 19 Nov 2009 09:00:00 +0100

Anacor Pharmaceuticals announced that it has dosed the first patient in a Phase I clinical study for AN3365, a novel boron-based, small-molecule drug candidate in development for the treatment of hospital infections caused by Gram-negative bacteria. The study will evaluate the safety, tolerability and pharmacokinetics of AN3365 in healthy volunteers. AN3365 targets the bacterial enzyme leucyl tRNA synthetase. (Source: Infectious Diseases / Bacteria / Viruses News From Medical News Today)

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Global Monitoring System Will Tell Whether HIV-Reduction Goals For 2015 Will Be Met

HIV / AIDS News From Medical News Today — Thu, 19 Nov 2009 09:00:00 +0100

Although much work remains to be done, a United Nations global reporting system on HIV/AIDS has already yielded an "unequaled wealth of data" on progress toward meeting UN targets for responding to the global HIV epidemic. An update on the development of the UN General Assembly Special Session on HIV/AIDS (UNGASS) global reporting system appears in a special supplement to JAIDS: Journal of Acquired Immune Deficiency Syndromes. (Source: HIV / AIDS News From Medical News Today)

Kenya: Stigma Hinders Fight Against TB

AllAfrica News: Tuberculosis — Thu, 19 Nov 2009 08:26:07 +0100

When Dorothy*, a single mother of five, told her neighbours in the Kenyan capital, Nairobi, she had tuberculosis (TB), she expected sympathy and maybe even offers of help. Instead, she found herself so severely ostracized, she felt she had to move out. (Source: AllAfrica News: Tuberculosis)

Botswana: Govt Reintroduces DDT to Eradicate Malaria

AllAfrica News: Malaria — Thu, 19 Nov 2009 07:51:28 +0100

Malaria remains a huge health challenge in Botswana and has compelled the government to reintroduce the use of Dichlo-Diphenyl Trichloroethane (DDT). (Source: AllAfrica News: Malaria)

South Africa: Sanac to Raise Awareness of HIV, Aids During 2010

AllAfrica News: HIV-Aids and STDs — Thu, 19 Nov 2009 06:46:17 +0100

The South African National AIDS Council (SANAC) symposium currently taking place in Johannesburg is trying to find ways to use the 2010 FIFA World Cup as a platform to advance awareness about HIV and AIDS. (Source: AllAfrica News: HIV-Aids and STDs)

Circumcision and Risk of Sexually Transmissible Infections in a Community-Based Cohort of HIV-Negative Homosexual Men in Sydney, Australia.

Herpes — Thu, 19 Nov 2009 05:36:08 +0100

Conclusions. These are the first prospective data obtained from homosexual men to assess circumcision status as a risk factor for STIs. Circumcised men were at reduced risk of incident syphilis but no other prevalent or incident STIs. Circumcision is unlikely to have a substantial public health impact in reducing acquisition of most STIs in homosexual men. PMID: 19911990 [PubMed - as supplied by publisher] (Source: Herpes)

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Prevalence of Trichomonas vaginalis infection among young reproductive age women in India: implications for treatment and prevention.

Herpes — Thu, 19 Nov 2009 05:36:05 +0100

Conclusion: The burden of T. vaginalis infection at 8.5% is relatively high among a community sample of young reproductive aged women. Because this infection increases the risk of HIV transmission and is associated with adverse pregnancy outcomes, there is a need for increased screening and treatment of this easily curable sexually transmissible infection in India. PMID: 19917204 [PubMed - in process] (Source: Herpes)

Am J Trop Med Hyg; +32 new citations

Am J Trop Med Hyg — Thu, 19 Nov 2009 05:10:02 +0100

32 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Trop Med Hyg These pubmed results were generated on 2009/11/19PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Trop Med Hyg)

UAB researchers discover antibody receptor identity, propose renaming immune-system gene

EurekAlert! - Infectious and Emerging Diseases — Thu, 19 Nov 2009 05:00:00 +0100

(University of Alabama at Birmingham) In what has eluded discovery for 30 years, scientists have identified a cellular receptor for the immune system's first-response antibody immunoglobulin M (IgM). The proposed name is the Fc mu receptor gene; it describes a key region of the IgM antibody that binds this receptor and fills in a crucial gap in understanding the science behind immune deficiencies and allergy diseases, says UAB researchers. (Source: EurekAlert! - Infectious and Emerging Diseases)

India-U.S. collaboration to prevent adolescent HIV infection: the feasibility of a family-based HIV prevention intervention for rural Indian youth

Journal of the International AIDS Society — Thu, 19 Nov 2009 00:00:00 +0100

Conclusions: Despite suggestions that family-based approaches to preventing adolescent HIV infection may be culturally inappropriate, our results suggest that a family-based intervention to prevent adolescent HIV infection is feasible for rural Indian families if it (1) provides families with relevant family-based prevention strategies and knowledge about HIV/AIDS, (2) addresses barriers to participation, (3) is adolescent-friendly, flexible, and convenient, and (4) is developmentally and culturally appropriate. (Source: Journal of the International AIDS Society)

In the national epidemiological bulletins - a selection from current issues

Eurosurveillance latest news — Thu, 19 Nov 2009 00:00:00 +0100

(Source: Eurosurveillance latest news)

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EMCDDA Annual report 2009: cocaine and heroin maintain firm hold on Europe's drug scene

Eurosurveillance latest news — Thu, 19 Nov 2009 00:00:00 +0100

(Source: Eurosurveillance latest news)

Introduction of human papillomavirus (HPV) vaccination in Belgium, 2007-2008

Eurosurveillance latest news — Thu, 19 Nov 2009 00:00:00 +0100

This paper documents the progress of human papillomavirus (HPV) vaccine introduction in Belgium. Information on vaccine use is based on sales statistics and reimbursement claims. From November 2007 to November 2008, the National Institute for Health and Disability Insurance reimbursed the HPV vaccine for girls aged between 12-15 years. In December 2008, the age limit was extended to include girls up to the age of 18. In November 2008, the total number of HPV vaccines sold exceeded 530,000 doses. The number of vaccines reimbursed in Belgium, for the period November 2007-November 2008, corresponds to the amount required to fully vaccinate 44% of all girls aged between 12-15 years. However, the trend was decreasing over the last 10 months. By the current reimbursement policy, we can expect th...

Oseltamivir-resistant influenza A(H1N1) viruses detected in Europe during season 2007-8 had epidemiologic and clinical characteristics similar to co-circulating susceptible A(H1N1) viruses

Eurosurveillance latest news — Thu, 19 Nov 2009 00:00:00 +0100

(Source: Eurosurveillance latest news)

"RAISIN" - a national programme for early warning, investigation and surveillance of healthcare-associated infection in France

Eurosurveillance latest news — Thu, 19 Nov 2009 00:00:00 +0100

We describe the development and current organisation of surveillance of HAI in France and summarise key achievements and results. Surveillance of HAI is under the auspice of the national institute for public health surveillance through a central coordinating structure, the Réseau d'alerte, d'investigation et de surveillance des infections nosocomiales (RAISIN), which consists of five regional coordinating structures, two national advisory committees of the Ministry of Health and public health agencies. Surveillance includes the performance of national prevalence surveys every five years (latest in 2006), specific surveillance networks to follow trends and characterise HAI that are national priority, and mandatory reporting of HAI that meet specific criteria for alert purposes. RAISIN prio...

Differentiation of two distinct clusters among currently circulating influenza A(H1N1)v viruses, March-September 2009

Eurosurveillance latest news — Thu, 19 Nov 2009 00:00:00 +0100

Analysis of all complete genome sequences of the pandemic influenza A(H1N1)v virus available as of 10 September 2009 revealed that two closely related but distinct clusters were circulating in most of the affected countries at the same time. The characteristic differences are located in genes encoding the two surface proteins - haemagglutinin and neuraminidase - and four internal proteins - the polymerase PB2 subunit, nucleoprotein, matrix protein M1 and the non-structural protein NS1. Phylogenetic inference was demonstrated by neighbour joining, maximum likelihood and Bayesian trees analyses of the involved genes and by tree construction of concatenated sequences. (Source: Eurosurveillance latest news)

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Genomic Tandem Repeat Analysis Proves Laboratory-Acquired Brucellosis in Veterinary (Camel) Diagnostic Laboratory in the United Arab Emirates

Zoonoses and Public Health — Thu, 19 Nov 2009 00:00:00 +0100

We report a case of a 64-year-old veterinarian working in a state camel veterinary laboratory who was diagnosed with and treated for acute brucellosis with complicating epididymo-orchitis. Genomic tandem repeat analysis (MLVA-16) revealed identical Brucella strains in patient cultures and from different dromedary milk samples positive for Brucella melitensis, thereby confirming the diagnosis of a laboratory acquired infection. The case illustrates the high (airborne) infectivity of brucellosis in laboratory settings and the need to implement vigorous bio-safety measures in veterinary laboratories handling camel specimen diagnostic veterinary laboratory. (Source: Zoonoses and Public Health)

Population structure analyses and demographic history of the malaria vector Anopheles albimanus from the Caribbean and the Pacific regions of Colombia

Malaria Journal — Thu, 19 Nov 2009 00:00:00 +0100

Conclusions: The data provide evidence for limited past gene flow between the Caribbean and the Pacific regions, as estimated by mtDNA sequences and current gene flow patterns among An. albimanus populations as measured by MS loci which may be mainly influenced by semi-permeable natural barriers in each biogeographical region that lead to the genetic differences and effective population sizes detected. The relatively high genetic differentiation in the port city of Buenaventura may be the result of specific ecological conditions, human migration and activities and/or differences in effective population sizes. This knowledge could serve to evaluate and coordinate vector control strategies in these regions of Colombia. (Source: Malaria Journal)

Erratum

HIV Medicine — Thu, 19 Nov 2009 00:00:00 +0100

(Source: HIV Medicine)

Hypothesis of snake and insect venoms against Human Immunodeficiency Virus: a review

AIDS Research and Therapy — Thu, 19 Nov 2009 00:00:00 +0100

Conclusion: With reference to mechanisms of action, properties and components of snake venom such as sequence homology and enzymes (protease or L- amino acid oxidase) may have an effect on membrane protein and/or act against HIV at multiple levels or cells carrying HIV virus resulting in enhanced effect of anti-retroviral therapy (ART). This may cause a decrease in viral load and improvement in clinical as well as immunological status. Insect venom and human Phospholipase A2 (PLA2) have potential anti-viral activity through inhibition of virion entry into the cells. However, all these require further evaluation in order to establish its role against HIV as an independent one or as a supplement. (Source: AIDS Research and Therapy)

Tanzania: TB Growing Concern Despite Efforts to Control It

AllAfrica News: Tuberculosis — Wed, 18 Nov 2009 23:01:25 +0100

TANZANIA is one of the 22 countries with the highest Tuberculosis burden in the world, despite having a well-functioning TB programme, based on World Health Organisation (WHO) strategy for the last 25 years. (Source: AllAfrica News: Tuberculosis)

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Rapid H1N1 Tests Miss the Virus in Most ICU Patients

MedPage Today Infectious Disease — Wed, 18 Nov 2009 21:00:00 +0100

The sensitivity of a rapid antigen test for pandemic H1N1 influenza was poor in Australian patients in intensive care, a small study showed. (Source: MedPage Today Infectious Disease)

Explanation and Summary of Changes to the 2008 National HIV Surveillance Report

CDC HIV/AIDS Prevention — Wed, 18 Nov 2009 17:00:00 +0100

Changes to the HIV Surveillance Report in response to customer feedback and the recognition of the need to present data to best meet the needs of data users. (Source: CDC HIV/AIDS Prevention)

Ukraine Dead Increase to 328 - Still No Sequences

Recombinomics — Wed, 18 Nov 2009 14:29:42 +0100

The commentary discusses a steady rise in H1N1 fatalities in Ukraine. A map of the outbreaks is linked. (11/17/09 19:17) (Source: Recombinomics)

Procalcitonin as a Biomarker for a Bacterial Infection on Hospital Admission: A Critical Appraisal in a Cohort of Travellers with Fever after a Stay in (Sub)tropics

Interdisciplinary Perspectives on Infectious Diseases — Wed, 18 Nov 2009 14:29:31 +0100

Fever in a returned traveller may be the manifestation of a self-limiting, trivial infection but it can also presage an infection that can be rapidly progressive and lethal. We studied the diagnostic accuracy of procalcitonin (PCT) as a biomarker for a bacterial cause of fever in a cohort of 157 consecutive travellers with fever after a stay in the (sub)tropics. Elevated procalcitonin levels were observed not only in about 50% of travellers with proven bacterial infection, but also in a significant proportion of travellers with a likely infection. Using a cutoff point of 0.5 ng/mL, procalcitonin had a sensitivity of 0.52 and a specificity of 0.76 for a bacterial cause of fever on admission. Interestingly, only 1 out of 16 patients with a proven viral infection had a marginally e...

Swine flu: intensive care beds for children 'could run out'

The Telegraph : Swine Flu A H1N1 — Wed, 18 Nov 2009 14:02:53 +0100

Intensive care beds for children could run out in Britain this winter due to swine flu researcher have warned. (Source: The Telegraph : Swine Flu A H1N1)

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25-Year Review Shows Last-Resort Lower-Body Amputation Effective In Extreme Cases

Infectious Diseases / Bacteria / Viruses News From Medical News Today — Wed, 18 Nov 2009 14:00:00 +0100

A landmark, 25-year review of cases in which surgeons had to remove the lower portion of the body from the waist down for severe pelvic bone infections shows the therapy can add years and quality of life to survivors, say researchers at UT Southwestern Medical Center. The rarely performed surgery is called a hemicorporectomy or translumbar amputation, and involves removing the entire body below the waist, including legs, pelvic bone and urinary system. (Source: Infectious Diseases / Bacteria / Viruses News From Medical News Today)

Also In Global Health News: Global Corruption; HIV Vaccine; Smoking; DRC Aid

HIV / AIDS News From Medical News Today — Wed, 18 Nov 2009 14:00:00 +0100

Global Corruption Fight Slowing, Report Says A new report from Transparency International says the fight against corruption worldwide is slowing as urgency to address the global economic downturn recedes, Bloomberg reports. (Source: HIV / AIDS News From Medical News Today)

AIDS Advocates Ask White House To Send Money South

HIV / AIDS News From Medical News Today — Wed, 18 Nov 2009 14:00:00 +0100

WLBT: "The White House Office of National AIDS Policy chose Jackson [Mississipppi] to host an HIV/AIDS town hall meeting Monday night. The community discussion allowed Mississippians to give feedback that will be included in a national strategy to end the HIV/AIDS epidemic. ... Many asked for sex and STD education in the schools, more doctors and transportation funding in rural areas and health insurance" (Anderson, 11/17). (Source: HIV / AIDS News From Medical News Today)

Dengue fever in Cape Verde - update 1

WHO Disease Outbreaks — Wed, 18 Nov 2009 11:01:00 +0100

As of 16 November 2009, the Ministry of Health has reported 16 744 suspected cases of dengue in five islands: Brava, Fogo, Maio, Sal and Santiago. (Source: WHO Disease Outbreaks)

FDA Clears The First Rapid Test To Detect Bacteria In Pooled Platelets

Infectious Diseases / Bacteria / Viruses News From Medical News Today — Wed, 18 Nov 2009 11:00:00 +0100

Fenwal, Inc., a global medical technology company focused on improving blood collection, separation, safety and availability, announced that the U.S. Food and Drug Administration has cleared the Verax Platelet PGD® test as a quality control test to detect bacterial contamination in whole blood-derived, pooled platelets prior to transfusion. Fenwal is the exclusive global distributor of the test, which was developed by Verax Biomedical of Worcester, Mass. (Source: Infectious Diseases / Bacteria / Viruses News From Medical News Today)

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Uganda: Like Aids, Climate Change Should Be Checked

AllAfrica News: HIV-Aids and STDs — Wed, 18 Nov 2009 10:43:27 +0100

When it was coined more than a decade ago, the term 'zero-grazing' became and still remains a very effective "action prompter" in the fight against the HIV/Aids pandemic. (Source: AllAfrica News: HIV-Aids and STDs)

New Products To Treat Neglected Diseases Are On The Rise, According To Tufts Center For The Study Of Drug Development

Infectious Diseases / Bacteria / Viruses News From Medical News Today — Wed, 18 Nov 2009 10:00:00 +0100

New products to treat neglected diseases have received marketing approval from regulatory agencies at a steadily increasing rate in recent years as R&D funding for those diseases has increased, according to a recently completed study by the Tufts Center for the Study of Drug Development. According to the study, the annual rate of new product approvals worldwide for neglected diseases increased from an average of 1.8 in 1975-99 to 2.6 in 2000-09. (Source: Infectious Diseases / Bacteria / Viruses News From Medical News Today)

E. Coli O157 In Surrey: Update, UK

Infectious Diseases / Bacteria / Viruses News From Medical News Today — Wed, 18 Nov 2009 10:00:00 +0100

The Health Protection Agency (HPA) reports that the total number of confirmed cases of E Coli O157 linked to Godstone Farm in Surrey remains 93. No cases are currently in hospital As the number of cases has remained the same for the past three weeks, there will be no further updates on figures linked to Godstone farm. (Source: Infectious Diseases / Bacteria / Viruses News From Medical News Today)

Statement Of The European Society Of Human Reproduction And Embryology On The European Commission Proposal Of Viral Screening In Assisted Reproduction

HIV / AIDS News From Medical News Today — Wed, 18 Nov 2009 10:00:00 +0100

With 900,000 assisted reproduction treatments annually such as IVF and intrauterine inseminations in Europe the Commission's proposal to screen both partners before each treatment could lead to costs of over EUR 140 million annually. These figures do not include the additional overhead costs such as administration, personnel and documentation that the hospitals would have to carry on top of that. (Source: HIV / AIDS News From Medical News Today)

Uganda: Malaria Illness on the Rise in Nkozi Area

AllAfrica News: Malaria — Wed, 18 Nov 2009 09:07:58 +0100

MALARIA infections top the list of patients seeking medical services at Nkozi Hospital, doctors have said. (Source: AllAfrica News: Malaria)

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Aradigm Doses First Patient In Long-Term Phase 2 Study Of A Novel Inhaled Ciprofloxacin Formulation For The Management Of Respiratory Infections

Infectious Diseases / Bacteria / Viruses News From Medical News Today — Wed, 18 Nov 2009 08:00:00 +0100

Aradigm Corporation (OTCBB:ARDM) (the "Company") announced that the first patient was dosed in a 6-month, multicenter, international Phase 2 clinical trial of a novel version of inhaled ciprofloxacin (ARD-3150) in 40 adult patients with non-cystic fibrosis bronchiectasis. The randomized, double-blind, placebo-controlled trial will be conducted in Australia and New Zealand. (Source: Infectious Diseases / Bacteria / Viruses News From Medical News Today)

Foodborne Illness: An Acute And Long-term Health Challenge For The 21st Century

Infectious Diseases / Bacteria / Viruses News From Medical News Today — Wed, 18 Nov 2009 08:00:00 +0100

The Center for Foodborne Illness Research & Prevention (CFI) has released a report that documents what is currently known about the long-term health outcomes associated with several foodborne illnesses. The report also discusses how under-reporting, inadequate follow-up and a lack of research make it difficult to assess the impact that foodborne illness is having on Americans. (Source: Infectious Diseases / Bacteria / Viruses News From Medical News Today)

FDA Grants Emergency Use Authorization To RocheÂ´s Assay For 2009 H1N1 Influenza Virus

Infectious Diseases / Bacteria / Viruses News From Medical News Today — Wed, 18 Nov 2009 08:00:00 +0100

Roche`s (SWX:RO) (SWX:ROG) (Pink Sheets: RHHBY) (Source: Infectious Diseases / Bacteria / Viruses News From Medical News Today)

Psychosocial Factors Associated with Successful Transition into HIV Case Management for those without Primary Care in an Urban Area

AIDS and Behavior — Wed, 18 Nov 2009 05:21:54 +0100

Abstract The purpose of this study was to identify the psychosocial factors which influence transitioning HIV positive clients without primary medical care to a case management agency within 6 weeks by a city brokerage agency. People living with HIV who reported being in a social support group and those who requested assistance with meeting their basic needs were significantly more likely to attend their first case management appointment within 6 weeks (adjusted OR 1.91 95% CI 1.22–2.97 and OR 1.24 95% CI 1.01–1.54, respectively). Individuals requesting medical care or substance abuse treatment were less likely to accomplish transitioning (adjusted OR 0.75 95% CI 0.59–0.95 and adjusted OR 0.70 95% CI 0.53–0.91, respectively). The implications of this stud...

Ascertaining Partner HIV Status and its Association with Sexual Risk Behavior Among Internet-Using Men Who Have Sex with Men

AIDS and Behavior — Wed, 18 Nov 2009 05:21:50 +0100

Abstract The aims of this study were to understand strategies and consistency of strategy used by HIV-negative and HIV-positive men who have sex with men (MSM) to ascertain the HIV status of their male sexual partners and their associations with unprotected anal intercourse (UAI) and serodiscordant UAI (SDUAI) in the past 3 months. Participants (n = 640) completed an online survey in December 2007. The most commonly reported strategy was checking online profiles (85%), followed by talking before sex (82%), talking after sex (42%), and guessing (29%). Adjusting for demographic and behavioral factors, guessing the HIV status of sex partners was associated with greater UAI and SDUAI partners, as was using an inconsistent strategy. Ascertaining HIV status before ...

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Incomplete Use of Condoms: The Importance of Sexual Arousal

AIDS and Behavior — Wed, 18 Nov 2009 05:21:47 +0100

Abstract The purpose of this study was to identify associations between incomplete condom use (not using condoms from start to finish of sex) and sexual arousal variables. A convenience sample of heterosexual men (n = 761) completed a web-based questionnaire. Men who scored higher on sexual arousability were more likely to put a condom on after sex had begun (AOR = 1.58). Men who reported difficulty reaching orgasm were more likely to report removing condoms before sex was over (AOR = 2.08). These findings suggest that sexual arousal may be an important, and under-studied, factor associated with incomplete use of condoms. Content Type Journal ArticleCategory ReportDOI 10.1007/s10461-009-9638-7Authors Cynthia A. Graham, University of Oxford ...

The relationship of Plasmodium falciparum humoral immunity with HIV-1 immunosuppression and treatment efficacy in Zambia

Malaria Journal — Wed, 18 Nov 2009 00:00:00 +0100

Conclusion: HIV-1 affects humoral responses to AMA-1, but seems to marginally or not affect humoral responses to other merozoite antigens and VSAs. The latter were important for controlling parasite density and predict treatment outcome. (Source: Malaria Journal)

Serum immunoglobulin G, M and A response to Cryptosporidium parvum in Cryptosporidium-HIV co-infected patients

BMC Infectious Diseases — Wed, 18 Nov 2009 00:00:00 +0100

Conclusions: The study showed specific serum IgG and IgA production in patients infected with Cryptosporidium, both HIV seropositive and seronegative as compared to uninfected subjects suggesting induction of Cryptosporidium specific humoral immune response in infected subjects. However, there was no difference in number of patients with positive response in HIV seropositive or seronegative groups indicating that HIV status may not be playing significant role in modulation of Cryptosporidium specific antibody responses. The number of patients with positive IgG, IgM and IgA response was not significantly different in patients with or without history of diarrhoea thereby indicating that Cryptosporidium specific antibody responses may not be necessarily associated with protection from symptom...

RtxA1‐Induced Expression of the Small GTPase Rac2 Plays a Key Role in the Pathogenicity of Vibrio vulnificus

The Journal of Infectious Diseases Latest Issue — Tue, 17 Nov 2009 22:42:01 +0100

The Journal of Infectious Diseases, Volume 0, Issue 0, Page 000, Latest Articles. Infection with the human pathogen Vibrio vulnificus leads to the generation of reactive oxygen species (ROS) via NAD(P)H oxidase (Nox) in host cells. In the present study, we employed mutant V. vulnificus strains to identify an essential virulence factor responsible for this ROS generation. We found that repeats‐in‐toxin A1 (RtxA1) expressed by V. vulnificus acts via Nox1 to induce significant ROS generation in the intestine epithelial cells, which ultimately results in cell death. Furthermore, RtxA1 modulates the small GTPase Rac2, which is known to play an important role in the activation of Nox. When mice were infected by the oral method, in contrast with the wild‐type bacteria, an RtxA1‐defi...

Nigeria: Jang - Corrupt Officials Deserve No Pity

AllAfrica News: HIV-Aids and STDs — Tue, 17 Nov 2009 22:18:04 +0100

Governor Jonah Jang of Plateau state yesterday called for strict punitive measures against government officials and organisationsinvolved in the diversion of funds meant for the fight against HIV/AIDS in the country. (Source: AllAfrica News: HIV-Aids and STDs)

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Scientist Begins To Unravel What Makes Pandemic H1N1 Tick

Infectious Diseases / Bacteria / Viruses News From Medical News Today — Tue, 17 Nov 2009 22:00:00 +0100

As the number of deaths related to the pandemic H1N1 virus, commonly known as "swine flu," continues to rise, researchers have been scrambling to decipher its inner workings and explain why the incidence is lower than expected in older adults. (Source: Infectious Diseases / Bacteria / Viruses News From Medical News Today)

Erratum: Kohut et al (J Infect Dis 2009; 200:1434–42)

The Journal of Infectious Diseases Latest Issue — Tue, 17 Nov 2009 21:51:26 +0100

The Journal of Infectious Diseases, Volume 200, Issue 12, Page 1949, 15 December 2009. (Source: The Journal of Infectious Diseases Latest Issue)

Reviewers of Volume 200

The Journal of Infectious Diseases Latest Issue — Tue, 17 Nov 2009 21:51:19 +0100

The Journal of Infectious Diseases, Volume 200, Issue 12, Page 1950-1953, 15 December 2009. The Journal of Infectious Diseases thanks its many reviewers for their valuable advice and criticism. (Source: The Journal of Infectious Diseases Latest Issue)

Africa: Africa Action Applauds U.S. Decision to Lift HIV Travel Ban, Calls for Sustained U.S. leadership on Global Health Ahead of Global Fund Board Meeting

AllAfrica News: HIV-Aids and STDs — Tue, 17 Nov 2009 20:36:33 +0100

Africa Action congratulates President Obama and the administration’s leadership in lifting the 22-year-old HIV travel and immigration ban in the U.S. Reducing stigma and discrimination associated with HIV is an integral part in the fight against HIV/AIDS and the promotion of human rights internationally. (Source: AllAfrica News: HIV-Aids and STDs)

Malawi: Trying to Give Sex Workers Safer Alternatives

AllAfrica News: HIV-Aids and STDs — Tue, 17 Nov 2009 20:32:20 +0100

A plan by Malawi to offer prostitutes low-interest loans to start small businesses in return for abandoning sex work is generating controversy in a country where women are disproportionately affected by high rates of poverty and HIV. (Source: AllAfrica News: HIV-Aids and STDs)

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New: Questions and Answers: 2009 H1N1 and Pneumococcal Disease in the News

CDC Swine Flu Updates — Tue, 17 Nov 2009 17:00:00 +0100

What is invasive pneumococcal disease? What does CDC know about invasive pneumococcal disease among people who get 2009 H1N1 or seasonal influenza? What is Active Bacterial Core surveillance (ABCs)? more... (Source: CDC Swine Flu Updates)

Mozambique: Production of Antiretrovirals to Start This Year

AllAfrica News: HIV-Aids and STDs — Tue, 17 Nov 2009 16:27:28 +0100

The first phase of a pharmaceutical plant to produce anti-retroviral drugs in Mozambique will begin before the end of this year, according to the Brazilian Minister of Development Industry and Foreign Trade, Miguel Jorge. (Source: AllAfrica News: HIV-Aids and STDs)

Vulnerable patients shunning swine flu vaccine GPs warn

The Telegraph : Swine Flu A H1N1 — Tue, 17 Nov 2009 15:12:35 +0100

More than half of patients being offered the swine flu vaccine are turning it down over safety concerns and the perception that the disease is mild according to a survey. (Source: The Telegraph : Swine Flu A H1N1)

Record Number of Lab Confirmed H1N1 Pediatric Deaths in the US

Recombinomics — Tue, 17 Nov 2009 14:24:35 +0100

The commentary discusses the record number of lab confirmed pediatric deaths in the United States. (11/16/09 16:09) (Source: Recombinomics)

Ukraine Dead Increase to 315 -Still No Sequences

Recombinomics — Tue, 17 Nov 2009 14:24:35 +0100

The commentary discusses the steady increase in fatalities in Ukraine. A map of the outbreak is linked. (11/16/09 19:17) (Source: Recombinomics)

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Ukraine H1N1 Sequence Changes Raise Concerns

Recombinomics — Tue, 17 Nov 2009 14:24:35 +0100

The commentary discusses the possible sequence changes is isolates from Ukraine. A map of the outbreaks is linked. (11/17/09 13:17) (Source: Recombinomics)

Cervical Radiculopathy

Disease a Month — Tue, 17 Nov 2009 14:23:55 +0100

Neck pain is a common complaint in the U.S. It is estimated that 30%-50% of adults will experience neck pain in a given year. Neck and back pain together account for about 65% of cases of disability, although neck pain less frequently leads to disability claims. Interestingly, neck pain has the highest frequency in those working in hospitals and offices, while those working in industrial/service and forestry sectors have the lowest frequency of neck pain. Women tend to have higher rates of trauma-related neck pain and demonstrate greater spinal motions. This may be related to men having anatomically wider and longer disk facet depth than women. Between 1993 and 1995 cervical spine conditions consumed 696,000 bed days during 161,000 hospitalizations with an average of 4.3 days per stay. Abo...

Cervical Facet Mediated Pain

Disease a Month — Tue, 17 Nov 2009 14:23:55 +0100

The Quebec Task Force on Whiplash-Associated Disorders defines whiplash as an acceleration-deceleration mechanism of energy transfer to the neck most often resulting from rear- or side-impact motor vehicle collisions; the impact often results in bony or soft-tissue injuries, which are referred to as whiplash injury. The varied symptoms arising from whiplash injury are termed whiplash associated disorders (WAD). (Source: Disease a Month)

Cervical Sprain/Strain Definition

Disease a Month — Tue, 17 Nov 2009 14:23:55 +0100

Cervical sprain/strain typically refers to acute pain arising from injured soft tissues of the neck, including muscles, tendons, and/or ligaments. The most common event leading to such injuries are motor vehicle collisions. The mechanism of injury is complex. Basically, when a vehicle is struck from behind, the initial head and neck acceleration lag behind vehicular acceleration. Eventually, head and neck acceleration reaches up to 2 and a half times the maximum car acceleration, which subsequently results in dramatic deceleration at end range of motion of the neck. While such injury can also result in fracture, discogenic, or neurologic injury, cervical strain or sprain, by definition, excludes these entities. (Source: Disease a Month)

Foreword

Disease a Month — Tue, 17 Nov 2009 14:23:54 +0100

In a previous issue, the authors discussed the pain generators in the lumbar spine that result in low back pain. Being part of the spinal column, the cervical spine has the same pain generators: paraspinal muscles, ligaments, nerve root, outer third of the intervertebral disk, periosteum, and facet joint; these are all discussed in this issue. However, the cervical spine does have several differences from the lumbar spine, which has clinical implications. The spinal cord is within the cervical spine, unlike the lumbar spine, where the cord ends at L1 in adults. The facet joints are oriented differently, allowing for more rotational motions. The atlas and axis articulate with the occiput, allowing for flexion/extension. These anatomical structures have greater clinical significance in the c...

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Disease a Month — Tue, 17 Nov 2009 14:23:54 +0100

(Source: Disease a Month)

Information for Readers

Disease a Month — Tue, 17 Nov 2009 14:23:54 +0100

(Source: Disease a Month)

Title Page

Disease a Month — Tue, 17 Nov 2009 14:23:54 +0100

(Source: Disease a Month)

Editorial Board

Disease a Month — Tue, 17 Nov 2009 14:23:54 +0100

(Source: Disease a Month)

HEALTH-SWAZILAND: On ART Since Birth

IPS Inter Press Service - HIV/AIDS — Tue, 17 Nov 2009 14:22:05 +0100

NHLANGANO, Swaziland, Nov 16 (IPS) - Seven-year-old Ntombi* frowns after swallowing the tablets her grandmother has given her. The HIV-positive child has contracted multi-drug-resistant tuberculosis (MDR-TB). (Source: IPS Inter Press Service - HIV/AIDS)

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New Government Oversight Of Food Supported By Majority Of Wyoming Voters, Pew-Commissioned Poll Finds

Infectious Diseases / Bacteria / Viruses News From Medical News Today — Tue, 17 Nov 2009 14:00:00 +0100

An overwhelming majority of Wyoming voters - 88 percent - support food safety legislation that would give the Food and Drug Administration (FDA) new authority to ensure the food Americans eat does not make them sick, according to a new poll commissioned by the Pew Health Group and conducted by Hart Research and Public Opinion Strategies. Support for stronger food protections is high regardless of voters' gender, income level or political affiliation. (Source: Infectious Diseases / Bacteria / Viruses News From Medical News Today)

Tunisia: 2009 JCI Congress Highlights Climate Change And Fight Against Malaria

AllAfrica News: Malaria — Tue, 17 Nov 2009 11:44:46 +0100

A news conference was held on Sunday at the sea side resort of Yasmine Hammamet as part of the 64th edition of the Junior International Congress JCI scheduled for November 16 to 21, 2009. (Source: AllAfrica News: Malaria)

Angola: Esperança Mutamba, 'I'm Living This Double Life'

AllAfrica News: HIV-Aids and STDs — Tue, 17 Nov 2009 11:00:55 +0100

Esperança Mutamba (not her real name), who has been living with the virus for 10 years and works as HIV/AIDS counsellor in the Angolan capital, Luanda, is still not ready to publicly disclose her HIV status. (Source: AllAfrica News: HIV-Aids and STDs)

Opinions: Health System Funding; Malnutrition Assistance; Social Dimension Of HIV

HIV / AIDS News From Medical News Today — Tue, 17 Nov 2009 11:00:00 +0100

Health System Funding Can Address 'Silent Killers' "For too long, global health funding has gone to diseases like AIDS with the most vocal lobby groups and not to the diseases with the greatest need," Philip Stevens, a senior fellow at International Policy Network, writes in a Business Daily opinion piece. (Source: HIV / AIDS News From Medical News Today)

NIH, D.C. Health Department To Launch HIV Treatment Study

HIV / AIDS News From Medical News Today — Tue, 17 Nov 2009 11:00:00 +0100

The Washington, D.C., Health Department and NIH are preparing to launch a study to determine whether aggressive treatment of all adults living with HIV could stop the spread of the virus and prevent AIDS, the Washington Post reports. The study's premise is based on a mathematical theory presented in 2008 by doctors at the (Source: HIV / AIDS News From Medical News Today)

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Nigeria: Abia to Eradicate Polio

AllAfrica News: Polio — Tue, 17 Nov 2009 10:18:23 +0100

Abia State Government has said it is determined to eradicate polio from the state before the end of next year. (Source: AllAfrica News: Polio)

Slowing Evolution To Stop Drug Resistance

Infectious Diseases / Bacteria / Viruses News From Medical News Today — Tue, 17 Nov 2009 10:00:00 +0100

The resistance of infectious organisms to antibiotics is particularly serious in drugs against fungi. Fungal cells are similar to human cells, which means that it is difficult to develop effective drugs that can destroy them without also damaging human cells, i.e. without causing side effects. We must therefore safeguard the effectiveness of the few antifungal drugs that are available today. Resistance to these would leave many diseases without effective treatment. (Source: Infectious Diseases / Bacteria / Viruses News From Medical News Today)

Study Shows Link Between Influenza Virus And Fever

Infectious Diseases / Bacteria / Viruses News From Medical News Today — Tue, 17 Nov 2009 10:00:00 +0100

Viruses are microscopically sized parasites. They plant their genes in the cells of their victim in order to 'reprogram' them. The infected cells then no longer produce what they need to live, making lots of new viruses instead. Luckily, in most cases this hostile takeover does not go unnoticed. This is ensured by the cells' own sensors that recognise alien genetic material. One of them is RIG-I. When RIG-I encounters virus genes, it ensures that the body releases interferon. (Source: Infectious Diseases / Bacteria / Viruses News From Medical News Today)

Pandemic (H1N1) 2009, Ukraine - update 2

WHO Swine Flu — Tue, 17 Nov 2009 10:00:00 +0100

Preliminary tests reveal no significant changes in the pandemic (H1N1) 2009 virus based on investigations of samples taken from patients in Ukraine. Analyses are being performed by two WHO influenza collaborating centres as part of the global influenza surveillance network. (Source: WHO Swine Flu)

Fears over 'own goal' HIV vaccine revived

New Scientist - HIV and AIDS — Tue, 17 Nov 2009 09:03:55 +0100

Cold virus used in vaccine may raise HIV infection risk after all (Source: New Scientist - HIV and AIDS)

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Scientists Put Interactive Flu Tracking At Public's Fingertips

Bird Flu / Avian Flu News From Medical News Today — Tue, 17 Nov 2009 08:00:00 +0100

New methods of studying avian influenza strains and visually mapping their movement around the world will help scientists more quickly learn the behavior of the pandemic H1N1 flu virus, Ohio State University researchers say. The researchers linked many powerful computer systems together to analyze enormous amounts of genetic data collected from all publicly available isolated strains of the H5N1 virus - the cause of avian flu. (Source: Bird Flu / Avian Flu News From Medical News Today)

Ghana: 60 Citizens Contract HIV Daily

AllAfrica News: HIV-Aids and STDs — Tue, 17 Nov 2009 07:25:02 +0100

Over 15,000 Ghanaians are estimated to die annually of the HIV and AIDS disease and a total of 33 milllion people globally live with HIV, according to worldwide statistics as disclosed by Dr Richard Amenyah of the Ghana AIDS Commission (GAC). (Source: AllAfrica News: HIV-Aids and STDs)

Ghana: Mewe Organizes 'Get Healthy' Cycle Race

AllAfrica News: Malaria — Tue, 17 Nov 2009 07:24:59 +0100

'MEWE',an Italian -based NGO orphanage, organized its fourth annual edition of the orphanage's rural bicycle race competition on at Wawase in the Twifo Hemang Lower Denkyira District at Central Region. (Source: AllAfrica News: Malaria)

South Africa: Experts Question Death Statistics

AllAfrica News: HIV-Aids and STDs — Tue, 17 Nov 2009 06:40:21 +0100

The Health Department's claim of a massive jump in deaths in 2008 is unlikely, according to experts (Source: AllAfrica News: HIV-Aids and STDs)

Nigeria: WACN Tackles HIV Transmission

AllAfrica News: HIV-Aids and STDs — Tue, 17 Nov 2009 06:00:55 +0100

In as much as mother-to-child-Transmission (MTCT)of HIV is almost entirely preventable where services are available, infant feeding choices for the HIV-infected women remains one of the most contentious issues in efforts to prevent MTCT of HIV in resource poor countries like Nigeria. (Source: AllAfrica News: HIV-Aids and STDs)

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GAVI's impact on vaccine market is bringing down prices

EurekAlert! - Infectious and Emerging Diseases — Tue, 17 Nov 2009 05:00:00 +0100

(GAVI Alliance) Following the increasing impact of the GAVI Alliance on the vaccine market, the price of one of the major combination vaccines, the pentavalent, is falling considerably, enabling GAVI's partners to vaccinate millions of more children in the developing world. (Source: EurekAlert! - Infectious and Emerging Diseases)

Immediate, aggressive spending on HIV/AIDS could end epidemic

EurekAlert! - Infectious and Emerging Diseases — Tue, 17 Nov 2009 05:00:00 +0100

(BioMed Central) Money available to treat HIV/AIDS is sufficient to end the epidemic globally, but only if we act immediately to control the spread of the disease, according to research published in BMC Public Health. This approach defies conventional thinking, which recommends gradual spending over 15-20 years. The study was based on a mathematical model developed by mathematicians and biologists, who recently earned acclaim for a study on how best to handle a planetary invasion by zombies. (Source: EurekAlert! - Infectious and Emerging Diseases)

Self-reported data: a major tool to assess compliance with anti-malarial combination therapy among children in Senegal

Malaria Journal — Tue, 17 Nov 2009 00:00:00 +0100

Conclusions: Self-reported data could provide useful quantitative information on drug intake and administration. Under strict methodological conditions this method, easy to implement, can be used to describe patients' behaviours and their use of new anti-malarial treatment. Self-reported data is a major tool for assessing compliance in resource poor countries. Blood and urine drug dosages provide qualitative results that confirm any drug intake. Urine assays for SP could be useful to obtain public health data, for example on chemoprophylaxis among pregnant women. (Source: Malaria Journal)

CKS topic review: Measles

NeLM - Infections — Tue, 17 Nov 2009 00:00:00 +0100

Source: CKS Area: Evidence > Guidelines This Topic Review from the Clinical Knowledge Service (CKS) covers the management of acute measles and post-exposure prophylaxis for measles. This topic does not cover the prevention of measles with the combined measles, mumps, and rubella (MMR) vaccine. (Source: NeLM - Infections)

Highlights From AASLD 2009

Clinical Care Options Hepatitis - HBV — Tue, 17 Nov 2009 00:00:00 +0100

CCO Slideset - Review the most clinically relevant new data from the 2009 AASLD conference on HCV, HBV, and complications of advanced liver disease. (Source: Clinical Care Options Hepatitis - HBV)

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A simple, noninvasive test for the diagnosis of liver fibrosis in patients with hepatitis C recurrence after liver transplantation

Journal of Viral Hepatitis — Tue, 17 Nov 2009 00:00:00 +0100

Summary. Recurrent hepatitis C is a common cause of graft loss in patients undergoing liver transplantation, and serial protocol liver biopsies have been used to identify patients at risk of graft loss from rapid fibrosis progression. The aim of this study was to derive a simple noninvasive index to predict fibrosis in patients with recurrent hepatitis C post-transplant. A retrospective study was performed assessing serial liver biopsies for post-transplant chronic hepatitis C infection. One hundred eighty-five patients were included in the analysis; median age 53 years (interquartile range 48[ndash]59) and 140 (76%) were male. Liver histology showed 53 (29%) had Ishak fibrosis stages F0/F1, 31 (17%) had F2, 29 (16%) had F3, 19 (10%) had F4 and 53 (29%) had F5/F6. The London Transplant Cen...

Swaziland: On ART Since Birth

AllAfrica News: HIV-Aids and STDs — Mon, 16 Nov 2009 23:57:20 +0100

Seven-year-old Ntombi* frowns after swallowing the tablets her grandmother has given her. The HIV-positive child has contracted multi-drug-resistant tuberculosis (MDR-TB). (Source: AllAfrica News: HIV-Aids and STDs)

Cryptosporidium parvum Induces B7‐H1 Expression in Cholangiocytes by Down‐Regulating MicroRNA‐513

The Journal of Infectious Diseases Latest Issue — Mon, 16 Nov 2009 21:21:04 +0100

We report here that the protozoan parasite Cryptosporidium parvum induced B7‐H1 expression in cultured human cholangiocytes. Induced expression of B7‐H1 was identified in cells after exposure to infective C. parvum parasite or parasite lysate. Interestingly, the level of microRNA‐513 (miR‐513) was reduced in cells after exposure to C. parvum, which resulted in a relief of 3′ untranslated region–mediated translational suppression of B7‐H1. Overexpression of miR‐513 through transfection of miR‐513 precursor inhibited C. parvum–induced B7‐H1 protein expression. Moreover, enhanced apoptotic cell death was identified in activated human T cells after coculture with C. parvum–infected cholangiocytes. The apoptosis of activated T cells was partially blocked by a neutralizin...

Zambia: Orphans Grow Up Without Cultural Identity

AllAfrica News: HIV-Aids and STDs — Mon, 16 Nov 2009 20:10:49 +0100

Abigail Mwanashimba has been looking after her five siblings since the age of eight, when her parents died of AIDS-related illnesses. She is now 19 years old, and without relatives to represent her at her lobola (bride price) negotiations, she was forced to hire traditional counsellors to organise the process of marriage according to the tribal customs. They did a bad job. (Source: AllAfrica News: HIV-Aids and STDs)

New: 2009 H1N1 Flu Information for People with Disabilities and Their Caregivers or Personal Assistants

CDC Swine Flu Updates — Mon, 16 Nov 2009 20:00:00 +0100

People with certain types of disability have a higher risk of getting flu-related complications, such as pneumonia. The 2009 H1N1 Flu Information for People with Disabilities and Their Caregivers or Personal Assistants is now available to the public at XXXX... (Source: CDC Swine Flu Updates)

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New: 2009 H1N1 Flu Information for People with Disabilities and Their Caregivers or Personal Assistants

CDC Flu updates — Mon, 16 Nov 2009 20:00:00 +0100

Effectiveness of Pediatric Antiretroviral Therapy in Resource‐Limited Settings: A Systematic Review and Meta‐analysis

Clinical Infectious Diseases Latest Issue — Mon, 16 Nov 2009 19:25:38 +0100

Clinical Infectious Diseases, Volume 0, Issue 0, Page 000, Latest Articles. Background. Responses to antiretroviral therapy (ART) among human immunodeficiency virus (HIV)–infected children in resource‐limited settings have recently been reported, but outcomes vary. We sought to derive pooled estimates of the 12‐month rate of virologic suppression (HIV RNA, (Source: Clinical Infectious Diseases Latest Issue)

Susceptibility of Poultry to Pandemic (H1N1) 2009 Virus, D.E. Swayne

Emerging Infectious Diseases Journal — Mon, 16 Nov 2009 18:00:00 +0100

(Source: Emerging Infectious Diseases Journal)

New Adenovirus in Bats, Germany, M. Sonntag et al.

Emerging Infectious Diseases Journal — Mon, 16 Nov 2009 18:00:00 +0100

(Source: Emerging Infectious Diseases Journal)

Transplacental Transmission of Bluetongue Virus 8 in Cattle, UK, K.E. Darpal et al.

Emerging Infectious Diseases Journal — Mon, 16 Nov 2009 18:00:00 +0100

(Source: Emerging Infectious Diseases Journal)

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Ghana: Suhum DCE Joins Citizens to Kick Out Polio

AllAfrica News: Polio — Mon, 16 Nov 2009 17:41:58 +0100

The District Chief Executive (DCE) of the Suhum Kraboa Coaltar Assembly, Mr. Sammy Kwabi, last Friday joined residents of the district to drum home the essence of polio immunisation in the country. (Source: AllAfrica News: Polio)

Swine flu: 'previous infection could offer some immunity'

The Telegraph : Swine Flu A H1N1 — Mon, 16 Nov 2009 17:40:34 +0100

The swine flu pandemic could be less severe than expected because previous flu infections have created some immunity to the virus a new study suggests. (Source: The Telegraph : Swine Flu A H1N1)

Mozambique: Mobile Unit to Fight Aids in Niassa

AllAfrica News: HIV-Aids and STDs — Mon, 16 Nov 2009 16:36:10 +0100

A multimedia mobile unit is now on the road in the northern Mozambican province of Niassa with the task of making communities aware of AIDS and how to prevent the disease, (Source: AllAfrica News: HIV-Aids and STDs)

Ukraine Dead Increase to 299 - Still No Sequences

Recombinomics — Mon, 16 Nov 2009 14:26:21 +0100

The commentary discusses the increase in H1N1 fatalities in Ukraine. A map of the outbreaks is linked. (11/15/09 22:55) (Source: Recombinomics)