MedWorm: Internal Medicine

Latest thrombosis guidelines issued by ACCP

MedWire News - Thrombosis — Thu, 09 Feb 2012 13:58:35 +0100

The American College of Chest Physicians has published the 9th Edition of its “Antithrombotic Therapy and Prevention of Thrombosis” guidelines in Chest this week. (Source: MedWire News - Thrombosis)

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Comparing health behaviours of internal medicine residents and medical students: An observational study.

Clinical and Investigative Medicine — Thu, 09 Feb 2012 11:54:09 +0100

Conclusion: Medical residents at our institution appear less active and consume fewer servings of fruits and vegetables than undergraduate medical students. These differences are associated with higher BMI, waist circumference and cardiovascular risk. PMID: 22309964 [PubMed - in process] (Source: Clinical and Investigative Medicine)

The Value of Federalism in Defining Essential Health Benefits

New England Journal of Medicine — Thu, 09 Feb 2012 09:00:18 +0100

New England Journal of Medicine, Volume 0, Issue 0, Ahead of Print. (Source: New England Journal of Medicine)

Preventable Adverse Drug Events Reduced By Computer Order Entry Systems

Health News from Medical News Today — Thu, 09 Feb 2012 09:00:00 +0100

Despite a national mandate to implement electronic health records and computer order entry systems (CPOE) by 2014, only approximately 30 percent of hospitals nationwide have done so and around 40 percent of hospitals in the state of Massachusetts have made this transition. New research from Brigham and Women's Hospital examined the impact of a vendor-developed CPOE in five community hospitals in Massachusetts and found that these CPOE systems are effective at reducing drug-related injury and harm. This research is published online in the Journal of General Internal Medicine... (Source: Health News from Medical News Today)

Fibronectin is essential for survival but is dispensable for proliferation of hepatocytes in acute liver injury

Hepatology — Thu, 09 Feb 2012 05:00:00 +0100

Conclusion: We provide evidence that the fibronectin‐mediated matrix survival signals for hepatocytes are transduced through the PI3‐kinase‐Bcl‐xL signaling axis in response to injury. This work defines fibronectin as a novel anti‐apoptotic factor for hepatocytes following acute liver injury but demonstrates that fibronectin is not essential for subsequent hepatocyte proliferation. (HEPATOLOGY 2012.) (Source: Hepatology)

Hepatitis C virus selectively perturbs the distal cholesterol synthesis pathway in a genotype specific manner

Hepatology — Thu, 09 Feb 2012 05:00:00 +0100

Conclusion: HCV G3, but not G2, selectively interferes with the late cholesterol synthesis pathway, evidenced by lower distal sterol metabolites and preserved lanosterol levels. This distal interference resolves with SVR. Normal lanosterol levels provide a signal for the continued proteolysis of HMGCoA reductase, which may undermine other host responses to increase cholesterol synthesis. This preliminary data may provide a hypothesis to explain why hypocholesterolemia persists in chronic HCV infection, particularly in HCV G3, and is not overcome by host cholesterol compensatory mechanisms. (HEPATOLOGY 2012.) (Source: Hepatology)

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Stat3‐mediated activation of miR‐23a suppresses gluconeogenesis in hepatocellular carcinoma by downregulating G6PC and PGC‐1α

Hepatology — Thu, 09 Feb 2012 05:00:00 +0100

Conclusion: Based on these data, we conclude that gluconeogenesis is severely compromised in HCC by IL6‐Stat3‐mediated activation of miR‐23a which directly targets PGC‐1α and G6PC, leading to decreased glucose production. (HEPATOLOGY 2012.) (Source: Hepatology)

Balloon occluded retrograde transvenous obliteration for the treatment of gastric varices

Hepatology — Thu, 09 Feb 2012 05:00:00 +0100

(Source: Hepatology)

Early diagnosis of HCC: It's not a matter of opinion

Hepatology — Thu, 09 Feb 2012 05:00:00 +0100

(Source: Hepatology)

Major vault protein: A virus‐induced host factor against viral replication through the induction of type‐I interferon

Hepatology — Thu, 09 Feb 2012 05:00:00 +0100

Conclusion:MVP is a novel virus‐induced host factor and its expression upregulates type‐I interferon production, leading to cellular antiviral responses. (HEPATOLOGY 2012.) (Source: Hepatology)

Role of transcriptional and post‐transcriptional regulation of methionine adenosyltransferases in liver cancer progression

Hepatology — Thu, 09 Feb 2012 05:00:00 +0100

In conclusion, we found for the first time a post‐transcriptional regulation of MAT1A and MAT2A by AUF1 and HuR in HCC. Low MATI/III:MATII ratio is a prognostic marker that contributes to determine a phenotype susceptible to HCC and patients' survival. Interference with cell cycle progression and IKK/NF‐kB signaling contributes to the anti‐proliferative and pro‐apoptotic effect of high SAM levels in HCC. (HEPATOLOGY 2012.) (Source: Hepatology)

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Hepatic androgen receptor suppresses hepatocellular carcinoma metastasis through modulation of cell migration and anoikis

Hepatology — Thu, 09 Feb 2012 05:00:00 +0100

Conclusions:Our study demonstrated that AR could orchestrate intrahepatic signalling hierarchies and cellular behaviours, thus consequently, manipulate cancer phenotype. Results from combination therapy shed a light on developing new therapeutic paradigm for battling HCC at later metastatic stage. (HEPATOLOGY 2012.) (Source: Hepatology)

Can racial disparities in optimal gout treatment be reduced? Evidence from a randomized trial

BMC Medicine — Thu, 09 Feb 2012 05:00:00 +0100

A recent trial in BMC Musculoskeletal Disorders reports urate-lowering therapy is equally effective in gout patients of different racial backgrounds, and Jasvinder Singh discusses the importance making this therapy more available to African-American patients in order to lower the burden of gout. (Source: BMC Medicine)

Gene Therapy Meets Stem Cells

New England Journal of Medicine — Wed, 08 Feb 2012 22:00:18 +0100

New England Journal of Medicine, Volume 366, Issue 6, Page 567-569, February 2012. (Source: New England Journal of Medicine)

Brain Stimulation, Learning, and Memory

New England Journal of Medicine — Wed, 08 Feb 2012 22:00:18 +0100

New England Journal of Medicine, Volume 366, Issue 6, Page 563-565, February 2012. (Source: New England Journal of Medicine)

Pyogenic Granuloma of the Finger

New England Journal of Medicine — Wed, 08 Feb 2012 22:00:18 +0100

New England Journal of Medicine, Volume 366, Issue 6, February 2012. (Source: New England Journal of Medicine)

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Reviewers for the Journal, July–December 2011

New England Journal of Medicine — Wed, 08 Feb 2012 22:00:17 +0100

New England Journal of Medicine, Volume 366, Issue 6, Page 566, February 2012. (Source: New England Journal of Medicine)

The Debate over Thyroid-Function Screening in Pregnancy

New England Journal of Medicine — Wed, 08 Feb 2012 22:00:17 +0100

New England Journal of Medicine, Volume 366, Issue 6, Page 562-563, February 2012. (Source: New England Journal of Medicine)

A Startling Decline

New England Journal of Medicine — Wed, 08 Feb 2012 22:00:17 +0100

New England Journal of Medicine, Volume 366, Issue 6, February 2012. (Source: New England Journal of Medicine)

IgG4-Related Disease

New England Journal of Medicine — Wed, 08 Feb 2012 22:00:17 +0100

New England Journal of Medicine, Volume 366, Issue 6, Page 539-551, February 2012. (Source: New England Journal of Medicine)

Memory Enhancement and Deep-Brain Stimulation of the Entorhinal Area

New England Journal of Medicine — Wed, 08 Feb 2012 22:00:17 +0100

New England Journal of Medicine, Volume 366, Issue 6, Page 502-510, February 2012. (Source: New England Journal of Medicine)

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The Emerging Threat of Untreatable Gonococcal Infection

New England Journal of Medicine — Wed, 08 Feb 2012 22:00:17 +0100

New England Journal of Medicine, Volume 366, Issue 6, Page 485-487, February 2012. (Source: New England Journal of Medicine)

Deep Sulcus Sign

New England Journal of Medicine — Wed, 08 Feb 2012 22:00:16 +0100

New England Journal of Medicine, Volume 366, Issue 6, Page 552, February 2012. (Source: New England Journal of Medicine)

Sources of Regional Variation in Medicare Part D Drug Spending

New England Journal of Medicine — Wed, 08 Feb 2012 22:00:16 +0100

New England Journal of Medicine, Volume 366, Issue 6, Page 530-538, February 2012. (Source: New England Journal of Medicine)

Systemic Lupus Erythematosus

New England Journal of Medicine — Wed, 08 Feb 2012 22:00:15 +0100

New England Journal of Medicine, Volume 366, Issue 6, Page 573-574, February 2012. (Source: New England Journal of Medicine)

Budesonide in Preschool-Age Children with Recurrent Wheezing

New England Journal of Medicine — Wed, 08 Feb 2012 22:00:14 +0100

New England Journal of Medicine, Volume 366, Issue 6, Page 570-571, February 2012. (Source: New England Journal of Medicine)

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Case 4-2012

New England Journal of Medicine — Wed, 08 Feb 2012 22:00:14 +0100

New England Journal of Medicine, Volume 366, Issue 6, Page 553-560, February 2012. (Source: New England Journal of Medicine)

Tai Chi and Postural Stability in Patients with Parkinson's Disease

New England Journal of Medicine — Wed, 08 Feb 2012 22:00:14 +0100

New England Journal of Medicine, Volume 366, Issue 6, Page 511-519, February 2012. (Source: New England Journal of Medicine)

Relationship between Cerebrospinal Fluid Glucose and Serum Glucose

New England Journal of Medicine — Wed, 08 Feb 2012 22:00:12 +0100

New England Journal of Medicine, Volume 366, Issue 6, Page 576-578, February 2012. (Source: New England Journal of Medicine)

Extracorporeal Membrane Oxygenation for ARDS in Adults

New England Journal of Medicine — Wed, 08 Feb 2012 22:00:12 +0100

New England Journal of Medicine, Volume 366, Issue 6, Page 575-576, February 2012. (Source: New England Journal of Medicine)

Mycophenolate or Azathioprine Maintenance in Lupus Nephritis

New England Journal of Medicine — Wed, 08 Feb 2012 22:00:12 +0100

New England Journal of Medicine, Volume 366, Issue 6, Page 572-573, February 2012. (Source: New England Journal of Medicine)

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Antenatal Thyroid Screening and Childhood Cognitive Function

New England Journal of Medicine — Wed, 08 Feb 2012 22:00:10 +0100

New England Journal of Medicine, Volume 366, Issue 6, Page 493-501, February 2012. (Source: New England Journal of Medicine)

Fair Enough? Inviting Inequities in State Health Benefits

New England Journal of Medicine — Wed, 08 Feb 2012 22:00:08 +0100

New England Journal of Medicine, Volume 0, Issue 0, Ahead of Print. (Source: New England Journal of Medicine)

Impact of Vendor Computerized Physician Order Entry in Community Hospitals

ICMCC: The International Council on Medical and Care Compunetics — Wed, 08 Feb 2012 09:39:43 +0100

Source: Leung AA et al, Journal of General Internal Medicine, 2011 Content: BACKGROUND It is uncertain if computerized physician order entry (CPOE) systems are effective at reducing adverse drug event (ADE) rates in community hospitals, where mainly vendor-developed applications are used. OBJECTIVE To evaluate the impact of vendor CPOE systems on the frequency of [...] (Source: ICMCC: The International Council on Medical and Care Compunetics)

Study Examines Misconceptions Of Who Picks Up Tab When Patients Walk Out

Health News from Medical News Today — Wed, 08 Feb 2012 08:00:00 +0100

There are ways in which patients who leave the hospital against medical advice wind up paying for that decision. Being saddled with the full cost of their hospital stay, however, is not one of them. Insurance companies know this. Patients who walk out may know this. But many physicians, according to a study published in the Journal of General Internal Medicine, do not... (Source: Health News from Medical News Today)

Zinc adjunct therapy reduces case fatality in severe childhood pneumonia: a randomized double blind placebo-controlled trial

BMC Medicine — Wed, 08 Feb 2012 05:00:00 +0100

Clinical trial evidence shows zinc supplementation can reduce mortality rates of children with severe pneumonia, having a greater effect in HIV positive infants, without reducing time to normalization of disease severity parameters. (Source: BMC Medicine)

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Relationship of health literacy to intentional and unintentional non-adherence of hospital discharge medications

NeLM - Care of Older People — Wed, 08 Feb 2012 05:00:00 +0100

Source: Journal of General Internal Medicine Area: Evidence > Medicines Management > References Background: Inadequate health literacy is prevalent among seniors and is associated with poor health outcomes. At hospital discharge, medications are frequently changed and patients are informed of these changes via their discharge instructions. Objectives: To explore the association between health literacy and medication discrepancies 48 hours after hospital discharge and determine the causes of discharge medication discrepancies. Design: Face-to-face surveys assessing health literacy at hospital discharge using the short form of the Test of Functional Health Literacy in Adults (sTOFHLA). We obtained the medication lists from the written discharge instructions. At...

News From The Annals Of Internal Medicine: Feb. 7 2012

Health News from Medical News Today — Tue, 07 Feb 2012 09:00:00 +0100

1. American College of Physicians Issues New Clinical Practice Guideline for Drug Treatment of Type 2 Diabetes ACP Recommends Metformin to Treat Type 2 Diabetes Based on Comparative Effectiveness Analysis of Oral Medications The American College of Physicians (ACP) recommends that clinicians add metformin as the initial drug treatment for most patients with type 2 diabetes when lifestyle modifications such as diet, exercise, and weight loss have failed to adequately improve high blood sugar... (Source: Health News from Medical News Today)

Spectrum of gluten-related disorders: consensus on new nomenclature and classification

BMC Medicine — Tue, 07 Feb 2012 05:00:00 +0100

Fasano et al. propose new nomenclature and classifications in the spectrum of gluten-related disorders (GRDs), prompted by indications that reactions to gluten may be caused by conditions other than celiac disease. (Source: BMC Medicine)

Engaging Men in Prevention and Care for HIV/AIDS in Africa

PLoS Medicine — Tue, 07 Feb 2012 05:00:00 +0100

by Edward J. Mills, Chris Beyrer, Josephine Birungi, Mark R. Dybul (Source: PLoS Medicine)

Prevalence, Distribution, and Impact of Mild Cognitive Impairment in Latin America, China, and India: A 10/66 Population-Based Study

PLoS Medicine — Tue, 07 Feb 2012 05:00:00 +0100

Conclusions An algorithm-derived diagnosis of aMCI showed few sociodemographic associations but was consistently associated with higher disability and neuropsychiatric symptoms in addition to showing substantial variation in prevalence across LAMIC populations. Longitudinal data are needed to confirm findings—in particular, to investigate the predictive validity of aMCI in these settings and risk/protective factors for progression to dementia; however, the large number affected has important implications in these rapidly ageing settings. Please see later in the article for the Editors' Summary (Source: PLoS Medicine)

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Characterisation of Clostridium difficile Hospital Ward–Based Transmission Using Extensive Epidemiological Data and Molecular Typing

PLoS Medicine — Tue, 07 Feb 2012 05:00:00 +0100

Conclusions In an endemic setting with well-implemented infection control measures, ward-based contact with symptomatic enzyme-immunoassay-positive patients cannot account for most new CDI cases. Please see later in the article for the Editors' Summary (Source: PLoS Medicine)

Clostridium: Transmission difficile?

PLoS Medicine — Tue, 07 Feb 2012 05:00:00 +0100

by Stephan Harbarth, Matthew H. Samore (Source: PLoS Medicine)

Computer order entry systems reduce preventable adverse drug events

EurekAlert! - Social and Behavioral Science — Tue, 07 Feb 2012 05:00:00 +0100

(Brigham and Women's Hospital) New research from Brigham and Women's Hospital examined the impact of a vendor-developed CPOE in five community hospitals in Massachusetts and found that these CPOE systems are effective at reducing drug-related injury and harm. This research is published online in the Journal of General Internal Medicine. (Source: EurekAlert! - Social and Behavioral Science)

Early Milk Intake and Risk of Advanced Prostate CancerEarly Milk Intake and Risk of Advanced Prostate Cancer

Medscape Today Headlines — Tue, 07 Feb 2012 04:00:00 +0100

This study looks at milk intake in adolescence and risk of prostate cancer in a cohort of Icelandic men. American Journal of Epidemiology (Source: Medscape Today Headlines)

Women and ICDs: More Complications and Fewer Benefits

Forbes.com Healthcare News — Mon, 06 Feb 2012 22:14:13 +0100

After consulting an electrophysiologist, women are just as likely as men to receive an ICD but they suffer more complications and are less likely to benefit from the device, according to a new study from Canada published in Annals of Internal Medicine. (Source: Forbes.com Healthcare News)

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Burden of pelvis fracture: a population-based study of incidence, hospitalisation and mortality

Osteoporosis International — Mon, 06 Feb 2012 19:37:21 +0100

Conclusions Pelvic fractures are associated with high rates of hospitalisation and mortality. Given this, further work is required to identify the optimal post-fracture therapeutic strategy to improve outcomes in this elderly patient group. Content Type Journal ArticleCategory Original ArticlePages 1-7DOI 10.1007/s00198-012-1907-zAuthors D. Prieto-Alhambra, Oxford NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Windmill Road, Headington, Oxford OX3 7LD, UKF. F. Avilés, Institut Català de la Salut—IDIAP Jordi Gol i Gurina, Barcelona, SpainA. Judge, Oxford NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoske...

Electronic Medical Record Availability and Primary Care Depression Treatment

Journal of General Internal Medicine — Mon, 06 Feb 2012 19:36:48 +0100

Conclusions EMRs appear to have an unintended negative association with depression care provided during visits made by primary care patients with multiple chronic conditions. Content Type Journal ArticleCategory Original ResearchPages 1-6DOI 10.1007/s11606-012-2001-0Authors Jeffrey S. Harman, Department of Health Services Research, Management and Policy, College of Public Health and Health Professions, University of Florida, Gainesville, FL, USAKathryn M. Rost, Department of Mental Health Law and Policy, Florida Mental Health Institute, University of South Florida, Tampa, FL, USAChristopher A. Harle, Department of Health Services Research, Management and Policy, College of Public Health and Health Professions, University of Florida, Gainesville, FL, USARobert L. Cook...

US Central-Line Infections to Be Disclosed Online US Central-Line Infections to Be Disclosed Online

Medscape Infectious Diseases Headlines — Mon, 06 Feb 2012 19:36:22 +0100

The Department of Health and Human Services has reported the incidence of hospital-associated infections for the first time. Medscape Medical News (Source: Medscape Infectious Diseases Headlines)

Central-Line Infections to be Disclosed NationwideCentral-Line Infections to be Disclosed Nationwide

Medscape Today Headlines — Mon, 06 Feb 2012 19:36:22 +0100

The Department of Health and Human Services has reported the incidence of hospital-associated infections for the first time. Medscape Medical News (Source: Medscape Today Headlines)

A case of IgG4-related pulmonary disease with rapid improvement

Modern Rheumatology — Mon, 06 Feb 2012 19:35:26 +0100

We report a 72-year-old man with respiratory involvement of immunoglobulin G4 (IgG4)-related disease, who developed dry cough and shortness of breath on effort. The chest computed tomography scan image showed massive and diffuse ground-glass opacity, interlobular thickening, and bronchial wall thickening. The infiltration of IgG4-positive plasma cells in the transbronchial lung biopsy and high serum IgG4 concentrations were found. The patient was treated with 0.6 mg/kg oral prednisolone and showed rapid improvement. This is a case of IgG4-related disease in which the only complication was respiratory involvement. Content Type Journal ArticleCategory Case ReportPages 1-5DOI 10.1007/s10165-012-0600-6Authors Masataka Umeda, Department of Rheumatology, Isahaya Health Insurance ...

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Pinch-1 was up-regulated in leukemia BMSC and its possible effect

Clinical and Experimental Medicine — Mon, 06 Feb 2012 19:34:38 +0100

This study focused on the expression of Pinch-1 in bone marrow stromal cells (BMSCs) from leukemia patients and its possible effect. BMSC was isolated and cultured from bone marrow in leukemia patients and normal healthy donors. RT-PCR and Western blot analysis were performed to determine Pinch-1 mRNA and protein level in BMSC, respectively. Lentiviral vector containing Pinch-1 siRNA was constructed, and the recombinant lentivirus particle was packaged in 293 cells. Effectiveness of Pinch-1 siRNA was determined by Western blot. The proliferation, apoptosis and motility of leukemia BMSC subjected to Pinch-1 knockdown using siRNA were tested by flow cytometry, TUNEL assay and Transwell system, respectively. Pinch-1 mRNA and protein were significantly up-regulated in ALL and AML BMSC co...

Coffee Lowers Liver Fibrosis Risk in Certain PatientsCoffee Lowers Liver Fibrosis Risk in Certain Patients

Medscape Today Headlines — Mon, 06 Feb 2012 19:21:42 +0100

Researchers have found that increased coffee drinking reduces the risk for liver fibrosis in people with nonalcoholic fatty liver disease. Medscape Medical News (Source: Medscape Today Headlines)

AIM: Women fare worse than men for ICD implants

Cardiovascular Business News — Mon, 06 Feb 2012 16:33:30 +0100

Rates of implantable cardioverter-defibrillator (ICD) implantation are similar among the sexes; however, women suffer from a greater risk of both major and minor complications, according to a study published in the Feb. 7 issue of the Annals of Internal Medicine. Researchers found that women were also less likely to receive appropriate ICD-delivered therapies when compared with men. (Source: Cardiovascular Business News)

Silent PE raises risk for early symptomatic PE in DVT patients

MedWire News - Thrombosis — Mon, 06 Feb 2012 13:46:06 +0100

Patients with silent pulmonary embolism at the time of deep vein thrombosis diagnosis have an increased risk for symptomatic PE during the first 2 weeks of therapy, study findings indicate. (Source: MedWire News - Thrombosis)

Unravelling modifiers of breast and ovarian cancer risk for BRCA1 and BRCA2 mutation carriers: update on genetic modifiers

Journal of Internal Medicine — Mon, 06 Feb 2012 05:00:00 +0100

AbstractPathogenic mutations in the tumour suppressor genes BRCA1 and BRCA2 confer increased risks for breast and ovarian cancer and account for approximately 15% of the excess familial risk of breast cancer among first degree relatives of breast cancer patients. There is considerable evidence indicating that these risks vary by other genetic and environmental factors clustering in families. In the past few years, based on the availability of genome‐wide association data and samples form large collaborative studies, several common alleles have been found to modify breast or ovarian cancer risk for BRCA1 and BRCA2 mutation carriers. These common alleles explain a small proportion of the genetic variability in breast or ovarian cancer risk for mutation carriers, suggesting more modifiers r...

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Resolving the Variable Genome and Epigenome in Human Disease

Journal of Internal Medicine — Mon, 06 Feb 2012 05:00:00 +0100

AbstractThe individual human genome and epigenome are being defined at unprecedented resolution by current advances in sequencing technologies with important implications for human disease. This review uses examples relevant to clinical practice to illustrate the functional consequences of genetic and epigenetic variation. The insights gained from genome‐wide association studies are described together with current efforts to understand the role of rare variants in common disease, set in the context of recent successes in Mendelian traits through application of whole exome sequencing. The application of functional genomics to interrogate the genome and epigenome, build up an integrated picture of the regulatory genomic landscape and inform disease association studies is discussed, togethe...

Role of common genetic variants in ovarian cancer susceptibility and outcome: progress to date from the ovarian cancer association consortium (OCAC)

Journal of Internal Medicine — Mon, 06 Feb 2012 05:00:00 +0100

AbstractIn this article, we review the current knowledge of the inherited genetics of epithelial ovarian cancer (EOC) susceptibility and clinical outcome. We focus on recent developments in identifying low‐penetrance susceptibility genes and the role of the ovarian cancer association consortium (OCAC) in these discoveries. The ovarian cancer association consortium (OCAC) was established to facilitate large‐scale replication analyses for reported genetic associations for EOC. Since its inception, the OCAC has conducted both candidate gene and genome wide association studies (GWAS); the latter has identified six established loci for EOC susceptibility most of which showed stronger association with the serous histological subtype. Future GWAS and sequencing studies are likely to result in...

Genetic Variants Associated With Predisposition to Prostate Cancer and Potential Clinical Implications

Journal of Internal Medicine — Mon, 06 Feb 2012 05:00:00 +0100

AbstractProstate cancer is the commonest cancer in the developed world. There is an inherited component to this disease as shown in familial and twin studies. However, the discovery of these variants has been difficult. The emergence of genome‐wide association studies (GWAS) has led to the identification of over 46 susceptibility loci. Their clinical utility to predict risk, response to treatment, or treatment toxicity, remains undefined. Large consortia are needed to achieve adequate statistical power to answer these genetic‐clinical and genetic‐epidemiological questions. International collaborations are currently underway to link genetic with clinical/epidemiological data to develop risk prediction models, which could direct screening and treatment programs. (Source: Journal of Int...

Screening mammography beliefs and recommendations: a web-based survey of primary care physicians

BMC Health Services Research — Mon, 06 Feb 2012 05:00:00 +0100

This study explored primary care physicians' (PCPs) perceptions of the influence of clinical practice guidelines for SM; the recommendations for SM in response to the hypothetical case scenarios; and the factors associated with perceived SM effectiveness and recommendations in the US from June to December 2009 before recently revised United States Preventive Services Task Force (USPSTF) guidelines. Methods: A nationally representative sample of 11,922 PCPs was surveyed using a web-based questionnaire. The response rate was 5.7% (684); (41%) 271 family physicians (FP), (36%) 232 general internal medicine physicians (IM), (23%) 150 obstetrician-gynaecologists (OBG), and (0.2%) 31 others. Cross-sectional analysis examined PCPs perceived effectiveness of SM, and recommendation for SM in respon...

Embargoed news for Annals of Internal Medicine

EurekAlert! - Cancer — Mon, 06 Feb 2012 05:00:00 +0100

(American College of Physicians) Below is information about articles being published in the Feb. 7 issue of Annals of Internal Medicine. The information is not intended to substitute for the full articles as sources of information. Annals of Internal Medicine attribution is required for all coverage. (Source: EurekAlert! - Cancer)

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Response to letter to the editor by Caturelli and Ghittoni

Hepatology — Mon, 06 Feb 2012 05:00:00 +0100

(Source: Hepatology)

I148M PNPLA3 variant and progressive liver disease: A new paradigm in hepatology

Hepatology — Mon, 06 Feb 2012 05:00:00 +0100

(Source: Hepatology)

Presence of precore and core promoter mutants limits the probability of response to peginterferon in HBeAg‐positive chronic hepatitis B

Hepatology — Mon, 06 Feb 2012 05:00:00 +0100

Conclusion:Presence of only WT virus at baseline is a strong predictor of response (HBeAg loss with HBV DNA <10,000 copies/mL) to PEG‐IFN for HBeAg‐positive CHB. Patients with detectable PC and/or BCP mutants have a lower probability of response and are less optimal candidates for PEG‐IFN therapy. (HEPATOLOGY 2012.) (Source: Hepatology)

Diarrhea predicts a positive response to sorafenib in patients with advanced hepatocellular carcinoma

Hepatology — Mon, 06 Feb 2012 05:00:00 +0100

(Source: Hepatology)

Assessment by fibroscan of fibrosis in NAFLD: XL vs. M probe?

Hepatology — Mon, 06 Feb 2012 05:00:00 +0100

(Source: Hepatology)

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Drug‐related adverse events may predict efficacy in sorafenib therapy for hepatocellular carcinoma

Hepatology — Mon, 06 Feb 2012 05:00:00 +0100

(Source: Hepatology)

MRC sum‐score in the ICU: Good reliability does not necessarily reflect ‘true reliability’

Muscle and Nerve — Mon, 06 Feb 2012 05:00:00 +0100

(Source: Muscle and Nerve)

Effect of stimulation intensity on assessment of voluntary activation

Muscle and Nerve — Mon, 06 Feb 2012 05:00:00 +0100

Discussion:Submaximal muscle stimulation can be used to estimate VA in the knee extensors. It is less painful, and overestimation of VA may be less compared to maximal nerve stimulation. © 2012 Wiley‐Liss, Inc. (Source: Muscle and Nerve)

Zoster‐associated mononeuropathies (ZAMs): A retrospective series

Muscle and Nerve — Mon, 06 Feb 2012 05:00:00 +0100

Conclusions:While ZAM is an uncommon occurrence following cutaneous HZ, it is associated with significant weakness, high rates of post‐herpetic neuralgia, and prolonged morbidity. © 2012 Wiley‐Liss, Inc. (Source: Muscle and Nerve)

A new model of experimental fibrosis in hindlimb skeletal muscle of adult mdx mouse mimicking muscular dystrophy

Muscle and Nerve — Mon, 06 Feb 2012 05:00:00 +0100

Discussion.This induced fibrotic dystrophic model may be useful to study mechanisms of fibrosis in dystrophinopathies and to evaluate antifibrotic treatments. © 2012 Wiley‐Liss, Inc. (Source: Muscle and Nerve)

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New motor outcome function measures in evaluation of late‐onset Pompe disease before and after ERT

Muscle and Nerve — Mon, 06 Feb 2012 05:00:00 +0100

DISCUSSION.GSGC is a group of functional tests that require only few minutes to perform, therefore, this score might be a good indicator to be used in future studies. © 2012 Wiley‐Liss, Inc. (Source: Muscle and Nerve)

Chronic inflammatory demyelinating polyneuropathy associated with alopecia totalis and Sjögren's syndrome

Muscle and Nerve — Mon, 06 Feb 2012 05:00:00 +0100

(Source: Muscle and Nerve)

Goya and a possible first visual representation of Charcot‐Marie‐Tooth disease

Muscle and Nerve — Mon, 06 Feb 2012 05:00:00 +0100

(Source: Muscle and Nerve)

The French Paradox and Other Ecological FallaciesThe French Paradox and Other Ecological Fallacies

Medscape Today Headlines — Mon, 06 Feb 2012 04:00:00 +0100

A historical perspective of ecological fallacies in medicine, which arise when disease differences identified between countries are assumed to be caused by factors that are found to also differ. International Journal of Epidemiology (Source: Medscape Today Headlines)

National Briefing | Health: Officials Recommend the HPV Vaccine for All Boys

NYT — Fri, 03 Feb 2012 19:20:07 +0100

Federal health officials recommended on Thursday that all boys be routinely vaccinated against infection with human papillomavirus, or HPV. (Source: NYT)

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Improvement in health-related quality of life in MPO-ANCA-associated vasculitis patients treated with cyclophosphamide plus prednisolone: an analysis of 18 months of follow-up data from the JMAAV study

Modern Rheumatology — Fri, 03 Feb 2012 17:51:16 +0100

Conclusion MPO-ANCA-associated vasculitis patients experienced a considerable deterioration in HRQOL. The standardized cyclophosphamide plus prednisolone regimen of the JMAAV study induced remission in the majority of patients, and the induction of remission accompanied a recovery in HRQOL. Content Type Journal ArticleCategory Original ArticlePages 1-8DOI 10.1007/s10165-012-0602-4Authors Machi Suka, Department of Public Health and Environmental Medicine, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-ku, Tokyo, 105-8461 JapanTaichi Hayashi, Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, JapanShigeto Kobayashi, Division of Internal Medicine, Juntendo University Koshigaya Hospital, Koshigaya, JapanSatoshi...

Single dose NTBC-treatment of hereditary tyrosinemia type I

Journal of Inherited Metabolic Disease — Fri, 03 Feb 2012 17:11:55 +0100

Abstract NTBC (2-(2-nitro-4-trifluoromethylbenzoyl)-1,3cyclohexanedione) is the mainstay of treatment in tyrosinemia type 1 (HT 1). The current recommendation is to divide the total daily dose of NTBC into two doses. We monitored the plasma NTBC concentrations in a series of seven patients who were changed from multiple divided doses to a single daily dose of NTBC. Two additional patients were started on a single daily dose of NTBC after the diagnosis of HT 1 was established. In three patients, NTBC kinetics were performed over 6 and 24 hours, respectively. The use of multiple divided doses or a single daily dose did not significantly affect plasma NTBC concentrations or the mean daily dose needed to attain therapeutic plasma NTBC concentrations. Moreover, kinetic studies ...

Protein farnesylation and disease

Journal of Inherited Metabolic Disease — Fri, 03 Feb 2012 17:11:53 +0100

Abstract Prenylation consists of the addition of an isoprenoid group to a cysteine residue located near the carboxyl terminal of a protein. This enzymatic posttranslational modification is important for the maturation and processing of proteins. Both processes are necessary to mediate protein-protein and membrane-protein associations, in addition to regulating the localisation and function of proteins. The severe phenotype of animals deficient in enzymes involved in both prenylation and maturation highlights the significance of these processes. Moreover, alterations in the genes coding for isoprenylated proteins or enzymes that are involved in both prenylation and maturation processes have been found to be the basis of severe human diseases, such as cancer, neurodegenerati...

Erratum

Postgraduate Medicine Online — Fri, 03 Feb 2012 14:21:35 +0100

DOI: 10.3810/pgm.2012.01.2531 Morales J. The pharmacologic basis for clinical differences among GLP-1 receptor agonists and DPP-4 inhibitors. Postgrad Med. 2011;123(6):189–201. read more (Source: Postgraduate Medicine Online)

Puzzles in Practice

Postgraduate Medicine Online — Fri, 03 Feb 2012 14:21:12 +0100

Yehia Y. Mishriki, MD, FACP and Brigid Hallinan, DO DOI: 10.3810/pgm.2012.01.2530 read more (Source: Postgraduate Medicine Online)

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Importance of Pharmacokinetic Profile and Timing of Coadministration of Short- and Long-Acting Formulations of Methylphenidate on Patterns of Subjective Responses and Abuse Potential

Postgraduate Medicine Online — Fri, 03 Feb 2012 14:18:35 +0100

Conclusion: These results emphasize the critical role that formulation type (IR vs OROS) and timing of administration (ascending vs descending phase) play when short- and long-acting formulations are coadministered. Such knowledge provides important information for clinicians about the safety and tolerability of the timing of repeat dosing of various permutations of coadministration of MPH formulations. Keywords: stimulants; drug abuse liability; attention-deficit/hyperactivity disorder read more (Source: Postgraduate Medicine Online)

The Nature, Assessment, and Treatment of Obsessive-Compulsive Disorder

Postgraduate Medicine Online — Fri, 03 Feb 2012 14:18:19 +0100

This article provides an introduction to the phenomenology, etiology, and clinical course of OCD. Assessment practices used to evaluate symptom severity are described, and evidence-based treatment options are reviewed, with appropriate distinctions drawn between children and adults. Finally, recommendations for assessment and treatment practices for OCD are explicated. Keywords: obsessive-compulsive disorder; assessment; treatment; phenomenology; etiology read more (Source: Postgraduate Medicine Online)

Life with Hereditary Angioedema:

Postgraduate Medicine Online — Fri, 03 Feb 2012 14:17:05 +0100

Then and Now Charles Joseph Lane, MD; J. Andrew Grant, MD; and Dane Dougherty, MS DOI: 10.3810/pgm.2012.01.2527 Abstract: Originally identified in 1882, hereditary angioedema (HAE) is a debilitating and potentially fatal disorder. Although a number of therapies have been identified, many are relatively ineffective or are associated with significant side effect concerns that limit their efficacy. Fortunately, the 2008 approval of plasma-derived C1 esterase inhibitor concentrate for disease prophylaxis provides clinicians with a novel and effective treatment unencumbered with severe side effect concerns for those with this debilitating disorder. However, despite advances in modern medicine, HAE remains a condition marked by a myriad of symptoms that mimic a range of other disorder...

Clinical Management of Elderly Patients with Type 2 Diabetes Mellitus

Postgraduate Medicine Online — Fri, 03 Feb 2012 14:16:41 +0100

This article reviews the epidemiology, pathophysiology, comorbidities, pharmacokinetic considerations, treatment goals, guidelines, and treatment options for the elderly population, and highlights the current knowledge gaps complicating the management of T2DM in this population. Keywords: type 2 diabetes mellitus; elderly; metformin; thiazolidinediones; incretin mimetics; DPP-4 inhibitors; GLP-1 read more (Source: Postgraduate Medicine Online)

Hypoglycemia, Treatment Discontinuation, and Costs in Patients with Type 2 Diabetes Mellitus on Oral Antidiabetic Drugs

Postgraduate Medicine Online — Fri, 03 Feb 2012 14:15:42 +0100

Conclusion: Different OAD classes were associated with different levels of risk for hypoglycemic events. Hypoglycemia was associated with a higher risk of antidiabetic treatment discontinuation and significantly increased health care costs. Keywords: hypoglycemia; type 2 diabetes mellitus; oral antidiabetic drug; treatment discontinuation; health care cost read more (Source: Postgraduate Medicine Online)

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The Pharmacokinetic Parameters of a Single Dose of a Novel Nano-formulated, Lower-Dose Oral Diclofenac

Postgraduate Medicine Online — Fri, 03 Feb 2012 14:15:09 +0100

Conclusion: The novel nano-formulated, lower-dose diclofenac demonstrated lower systemic exposure, comparable Cmax, and faster absorption compared with diclofenac. In light of the advisory issued by worldwide regulatory agencies regarding use of lowest effective doses, these data may permit use of lower NSAID doses that improve safety and tolerability while, at minimum, relieving pain similar to standard formulations. Keywords: NSAID; diclofenac; nanotechnology read more (Source: Postgraduate Medicine Online)

Contemporary Management of Overactive Bladder

Postgraduate Medicine Online — Fri, 03 Feb 2012 14:14:13 +0100

This article addresses the contemporary management of overactive bladder, including behavioral and lifestyle modifications, pelvic floor muscle therapy, biofeedback, drug therapy, neuromodulation, and botulinum toxin. We highlight the new drugs and therapies that have been brought into clinical use over the past few years, and discuss important clinical implications of therapy as well as promising new agents that are currently in advanced stages of development. Keywords: overactive bladder; behavioral modification; biofeedback; antimuscarinics; neuromodulation; botulinum toxin read more (Source: Postgraduate Medicine Online)

Hypoactive Sexual Desire Disorder in Premenopausal Women:

Postgraduate Medicine Online — Fri, 03 Feb 2012 14:12:49 +0100

This article gives an overview of HSDD in clinical practice and provides 3 case descriptions to illustrate the treatment of low sexual desire in women with diverse histories. Keywords: primary care provider; metabolic syndrome; breast cancer; androgen insufficiency; female sexual dysfunction; hypoactive sexual desire disorder read more (Source: Postgraduate Medicine Online)

A Systematic Review of Duloxetine for Osteoarthritic Pain:

Postgraduate Medicine Online — Fri, 03 Feb 2012 14:12:10 +0100

Conclusions: Duloxetine appears efficacious and tolerable for the treatment of chronic pain associated with OA. The NNT and NNH can be used to quantify efficacy and tolerability outcomes and help place duloxetine into clinical perspective. Likelihood to be helped or harmed can illustrate to the clinician and patient the trade-offs between obtaining potential benefits versus harms. Head-to-head comparisons of duloxetine with other interventions for OA, as well as controlled trials of duloxetine in combination with other therapies, would be desirable. Keywords: adverse events; duloxetine; efficacy; number needed to harm; number needed to treat; osteoarthritis; pain; safety; tolerability read more (Source: Postgraduate Medicine Online)

Evaluation and Pharmacologic Approach to Patients with Resistant Hypertension

Postgraduate Medicine Online — Fri, 03 Feb 2012 14:11:44 +0100

This article focuses on the safety and efficacy of spironolactone when added to an optimized 3-drug regimen. Additionally, the use of spironolactone in chronic kidney disease and obstructive sleep apnea complicated by resistant hypertension is discussed. These 2 clinical entities are frequently accompanied by resistant hypertension and are indications for the use of spironolactone as well. Keywords: hypertension; resistant hypertension; spironolactone; treatment; chronic kidney disease; obstructive sleep apnea; renin-angiotensin-aldosterone system read more (Source: Postgraduate Medicine Online)

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Recent Advancements in the Treatment of Resistant Hypertension

Postgraduate Medicine Online — Fri, 03 Feb 2012 14:09:34 +0100

Donald Clark III, MD; Jason L. Guichard, MD, PhD; David A. Calhoun, MD; and Mustafa I. Ahmed, MD DOI: 10.3810/pgm.2012.01.2519 Abstract: The 2008 scientific statement from the American Heart Association defined resistant hypertension as blood pressure remaining above goal (< 140/90 mm Hg for the general population and < 130/80 mm Hg for patients with diabetes or renal disease) despite the concurrent use of optimal doses of 3 antihypertensive agents of different classes, ideally including a diuretic. Since then, there has been increasing recognition and characterization of patients with resistant hypertension and development of treatment strategies to treat this high-risk population. The role of aldosterone in resistant hypertension has gained increasing recognition. In particul...

Over 10% of lower extremity DVT cases isolated to calf

MedWire News - Thrombosis — Fri, 03 Feb 2012 14:08:27 +0100

More than one in 10 cases of lower extremity deep vein thrombosis are isolated to the distal calf, results of a community-based study show. (Source: MedWire News - Thrombosis)

Chlorthalidone:

Postgraduate Medicine Online — Fri, 03 Feb 2012 14:07:06 +0100

This article reviews the comparative clinical data between chlorthalidone and hydrochlorothiazide, the pharmacologic properties that might explain some of their differences regarding half-life and efficacy, and what is known about the effect of chlorthalidone on intermediate endpoints. Keywords: hypertension; diuretics; chlorthalidone; hydrochlorothiazide read more (Source: Postgraduate Medicine Online)

Current Approaches to the Treatment of Hypertension in Older Persons

Postgraduate Medicine Online — Fri, 03 Feb 2012 14:06:20 +0100

Wilbert S. Aronow, MD, FACC, FAHA DOI: 10.3810/pgm.2012.01.2517 Abstract: Hypertension is a major risk factor for cardiovascular disease and is present in 69% of patients with a first myocardial infarction, in 77% of patients with a first stroke, in 74% of patients with chronic heart failure, and in 60% of patients with peripheral arterial disease. Double-blind, randomized, placebo-controlled trials have demonstrated that antihypertensive drug therapy reduces cardiovascular events in patients aged 65 to 79 years. In the Hypertension in the Very Elderly Trial, patients aged ≥ 80 years who were treated with antihypertensive drug therapy had, at 1.8-year follow-up, a 30% reduction in fatal or nonfatal stroke (P = 0.06), a 39% reduction in fatal stroke (P = 0.05), a 21% reduction in a...

Anticoagulation Prophylaxis in Orthopedic Surgery:

Postgraduate Medicine Online — Fri, 03 Feb 2012 13:58:07 +0100

Conclusion: Traditional cost-effectiveness analysis systematically excludes information related to the safety profiles of these anticoagulants. The efficiency frontier approach presented in this study provides critical information, without substantial effort, to permit a fully informed decision by taking into account all relevant outcomes as they relate to the costs associated with treatment choice. Keywords: orthopedic surgery; efficiency frontier; venous thromboembolism; total knee arthroplasty; total hip arthroplasty read more (Source: Postgraduate Medicine Online)

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Clinical Management Considerations for Dyslipidemia in HIV-Infected Individuals

Postgraduate Medicine Online — Fri, 03 Feb 2012 13:57:38 +0100

Jeffrey T. Kirchner, DO, FAAFP, AAHIVS DOI: 10.3810/pgm.2012.01.2515 Abstract: Dyslipidemia is common in patients with human immunodeficiency virus (HIV) and may result in significant morbidity, including coronary heart disease (CHD). Treatment of dyslipidemia in these patients is generally based on the National Cholesterol Education Program Adult Treatment Panel III goals for individuals without HIV. For individuals with ≥ 2 cardiovascular risk factors, the risk of CHD should be evaluated using the Framingham risk calculator and managed accordingly. Switching to an antiretroviral regimen with a favorable lipid profile should be considered before pharmacologic management if virologic suppression can be maintained. Statins are the first-choice therapy for elevated low-density lipop...

Metabolic Syndrome:

Postgraduate Medicine Online — Fri, 03 Feb 2012 13:56:38 +0100

Definition and Therapeutic Implications Hari Prasad, MD; Debra A. Ryan, MD; Ma Florence Celzo, MD; and Dwight Stapleton, MD DOI: 10.3810/pgm.2012.01.2514 Abstract: The collection of impaired glucose metabolism, central obesity, elevated blood pressure, and dyslipidemia is identified as metabolic syndrome (MetS). It is estimated that approximately 25% of the world’s population has MetS. In the United States, MetS is more common in men and Hispanics, and its incidence increases with age. Metabolic syndrome increases the risk of developing cardiovascular disease and type 2 diabetes mellitus. The underlying risk factors include insulin resistance and abdominal obesity. Confusion about MetS exists in part due to the lack of a consensus definition and treatment protocol. Treatme...

Combination Treatment with Atorvastatin Plus Niacin Provides Effective Control of Complex Dyslipidemias:

Postgraduate Medicine Online — Fri, 03 Feb 2012 13:54:43 +0100

A Literature Review James M. McKenney, PharmD DOI: 10.3810/pgm.2012.01.2513 Abstract: Patients with dyslipidemia receive a cardiovascular benefit from lowering low-density lipoprotein cholesterol (LDL-C). Atorvastatin is currently one of the most effective approved medications for lowering LDL-C, and has been shown to significantly reduce cardiovascular risk in many patient groups. However, even with substantial lowering of LDL-C with atorvastatin, patients still have a residual risk for coronary heart disease. Elevated triglyceride levels and low high-density lipoprotein cholesterol (HDL-C) levels may contribute to this risk. Approved medications targeting these secondary lipid parameters include fibrates, omega-3 fatty acids, and niacin. Among these medications, niacin provide...

Two Studies Find that Patients Want Access to their Health Records, Including Clinical Pathology Test Data

Dark Daily — Fri, 03 Feb 2012 11:00:27 +0100

Patients are ready to ready access to their medical records; but physicians are wary Data from two studies here in the United States affirms that patients want access to their health records. Consequently, health systems are increasingly making it easier for patients to get access to prescription lists, medical laboratory test results and now even [...] (Source: Dark Daily)

Apparent heparin resistance in a patient with infective endocarditis secondary to elevated factor VIII levels

Journal of Thrombosis and Thrombolysis — Fri, 03 Feb 2012 07:22:02 +0100

Abstract Heparin resistance (HR) is defined as increasing requirements of heparin to maintain a therapeutic activated partial thromboplastin time (aPTT). It is commonly associated with antithrombin deficiency, increased heparin clearance and elevations in heparin binding proteins. Elevated factor VIII levels can cause decrease the aPTT levels (anticoagulant effect) without disturbing heparin activity measured by anti-Xa assay (antithrombotic effect) leading to an apparent heparin resistant state rather than a true heparin resistance. We highlight the importance of increasing awareness of apparent HR and early distinction from true resistance to avoid major life threatening hemorrhagic complications. We hereby report an unusual case of heparin resistance due to increased fa...

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From the Editors’ Desk: Improving Performance Through Coaching, Incentives, Feedback, and Practice

Journal of General Internal Medicine — Fri, 03 Feb 2012 07:20:49 +0100

Content Type Journal ArticlePages 1-2DOI 10.1007/s11606-012-1999-3Authors Richard L. Kravitz, Division of General Medicine, University of California Davis, Sacramento, CA, USA Journal Journal of General Internal MedicineOnline ISSN 1525-1497Print ISSN 0884-8734 (Source: Journal of General Internal Medicine)

Enhancing Care for Hospitalized Older Adults with Cognitive Impairment: A Randomized Controlled Trial

Journal of General Internal Medicine — Fri, 03 Feb 2012 07:20:49 +0100

Conclusion A simple screening program for CI followed by a CDSS did not change physician prescribing behaviors or improve the process of care for hospitalized older adults with CI. Content Type Journal ArticleCategory Original ResearchPages 1-7DOI 10.1007/s11606-012-1994-8Authors Malaz A. Boustani, Indiana University Center for Aging Research, Indianapolis, IN, USANoll L. Campbell, Indiana University Center for Aging Research, Indianapolis, IN, USABabar A. Khan, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USAGreg Abernathy, Regenstrief Institute, Inc, 410 West 10th Street, Suite 2000, Indianapolis, IN 46202, USAMohammed Zawahiri, Indiana University Center for Aging Research, Indianapolis, IN, USATiffany Campbell, Indiana Universit...

Inappropriate Medication in Home Health Care

Journal of General Internal Medicine — Fri, 03 Feb 2012 07:20:48 +0100

Content Type Journal ArticleCategory LettersPages 1-1DOI 10.1007/s11606-012-1997-5Authors Yuhua Bao, Department of Public Health, Weill Cornell Medical College, 402 E. 67th St., New York, NY 10065, USAHuibo Shao, Department of Public Health, Weill Cornell Medical College, 402 E. 67th St., New York, NY 10065, USATara F. Bishop, Departments of Public Health and Medicine, Weill Cornell Medical College, New York, NY, USABruce R. Schackman, Department of Public Health, Weill Cornell Medical College, 402 E. 67th St., New York, NY 10065, USAMartha L. Bruce, Department of Psychiatry, Weill Cornell Medical College, White Plains, NY, USA Journal Journal of General Internal MedicineOnline ISSN 1525-1497Print ISSN 0884-8734 (Source: Journal of General Internal Medicine)

Communication and Behavior Change Challenges to Limiting the Development of Antibiotic Resistance

Journal of General Internal Medicine — Fri, 03 Feb 2012 07:20:46 +0100

Content Type Journal ArticleCategory EditorialsPages 1-2DOI 10.1007/s11606-012-2000-1Authors Timothy Edgar, Department of Communication Sciences and Disorders, Emerson College, 120 Boylston Street, Boston, MA 02116, USA Journal Journal of General Internal MedicineOnline ISSN 1525-1497Print ISSN 0884-8734 (Source: Journal of General Internal Medicine)

Improving test properties for neonatal cystic fibrosis screening in the Netherlands before the nationwide start by May 1st 2011

Journal of Inherited Metabolic Disease — Fri, 03 Feb 2012 07:20:33 +0100

Abstract When new technical possibilities arise in health care, often attunement is needed between different actors from the perspectives of research, health care providers, patients, ethics and policy. For cystic fibrosis (CF) such a process of attunement in the Netherlands started in a committee of the Health Council on neonatal screening in 2005. In the balancing of pros and cons according to Wilson and Jungner criteria, the advantages for the CF patient were considered clear, even though CF remains a severe health problem with treatment. Nevertheless, screening was not started then, mainly since the specificity of the tests available at that time was considered too low. Many healthy infants would have been referred for sweat testing and much uncertainty would arise in ...

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Evidence for a genetic role in varicose veins and chronic venous insufficiency.

Phlebology — Fri, 03 Feb 2012 05:00:00 +0100

Authors: Krysa J, Jones GT, van Rij AM Abstract There is a strong body of circumstantial evidence which implicates genetics in the aetiology and pathology of varicose veins and venous ulcer disease. The aim of this review is to consider the current knowledge of the genetic associations and the ways in which new genetic technologies may be applied to advancing our understanding of the cause and progression of these venous diseases. A number of publications have used a candidate gene approach to identify genes implicated in venous disease. Although these studies have opened up important new insights, there has been a general failure to replicate results in an independent cohort of patients. With our limited knowledge of the biological pathways involved in the pathogenesis of venous d...

Inflammation and related biomarkers in cardiovascular disease

Future Medicine: Biomarkers in Medicine — Fri, 03 Feb 2012 04:00:24 +0100

Biomarkers in Medicine , February 2012, Vol. 6, No. 1, Pages 1-3. (Source: Future Medicine: Biomarkers in Medicine)

National Briefing | Health: Officials Recommend the HPV Vaccine for All Boys

NYT Health — Fri, 03 Feb 2012 01:10:05 +0100

Federal health officials recommended on Thursday that all boys be routinely vaccinated against infection with human papillomavirus, or HPV. (Source: NYT Health)

Matrix metalloproteinases in metabolic syndrome.

European Journal of Internal Medicine — Fri, 03 Feb 2012 00:28:42 +0100

Authors: Hopps E, Caimi G Abstract Metabolic syndrome is commonly accompanied by an elevated cardiovascular risk with high morbidity and mortality. The alterations of the arterial vasculature begin with endothelial dysfunction and lead to micro- and macrovascular complications. The remodeling of the endothelial basal membrane, that promotes erosion and thrombosis, has a multifactorial pathogenesis that includes leukocyte activation, increased oxidative stress and also an altered matrix metalloproteinases (MMPs) expression. MMPs are endopeptidases which degrade extracellular matrix proteins, such as collagen, gelatins, fibronectin and laminin. They can be secreted by several cells within the vascular wall, but macrophages are determinant in the atherosclerotic plaques. Their activit...

On the nature of sarcoidosis.

European Journal of Internal Medicine — Fri, 03 Feb 2012 00:28:32 +0100

Authors: Reich JM Abstract More than 140years since its recognition as a clinical entity, sarcoidosis remains enigmatic. Its classification as a disease vs. a syndrome is uncertain. Its etiology remains undefined. The "immune paradox" (delayed type hypersensitivity anergy in a setting of exuberant systemic granulomatous response) resists explanation. Its relationship to the Kveim test is poorly understood. Its prognostic determinants and treatment indications are among the unsolved or disputed problems. Immunological investigations generated the thesis that the characterizing systemic granuloma arise as a fallback reaction to inefficient cellular immune processing, due most often to impaired myeloid dendritic cell function of unknown cause. The concept that sarcoidosis represents a...

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Excessive daytime sleepiness and narcolepsy - An approach to investigation and management.

European Journal of Internal Medicine — Fri, 03 Feb 2012 00:28:21 +0100

Authors: Morrison I, Riha RL Abstract Excessive daytime sleepiness is a common presentation to physicians both in general practice and hospital settings. In this review, we provide an update on the latest theories on the pathogenesis of the condition, and discuss the approach to investigation of the sleepy patient, with particular reference to narcolepsy. Recommended therapy is reviewed for both narcolepsy and cataplexy, to provide physicians with an important reference on the investigation and management of these troubling conditions. PMID: 22284238 [PubMed - in process] (Source: European Journal of Internal Medicine)

The frailty dilemma. Review of the predictive accuracy of major frailty scores.

European Journal of Internal Medicine — Fri, 03 Feb 2012 00:28:11 +0100

CONCLUSIONS: As the number of false positive values of most available tests is substantial, these frailty scores are of limited value for both screening and diagnostic purposes in daily practice. As diagnostic instruments they can best be used to exclude frailty. The false-positive rate of currently available tests is too high to allow major decisions on medical care to be made on the basis of a positive test. PMID: 22284239 [PubMed - in process] (Source: European Journal of Internal Medicine)

Prevention of delirium in demented hospitalized patients.

European Journal of Internal Medicine — Fri, 03 Feb 2012 00:28:01 +0100

Authors: Andro M, Comps E, Estivin S, Gentric A PMID: 22284240 [PubMed - in process] (Source: European Journal of Internal Medicine)

Dipeptidylpeptidase-4 (DPP-4) inhibitors are favourable to glucagon-like peptide-1 (GLP-1) receptor agonists: Yes.

European Journal of Internal Medicine — Fri, 03 Feb 2012 00:27:50 +0100

Authors: Scheen AJ Abstract The pharmacological treatment of type 2 diabetes (T2DM) is becoming increasingly complex, especially since the availability of incretin-based therapies. Compared with other glucose-lowering strategies, these novel drugs offer some advantages such as an absence of weight gain and a negligible risk of hypoglycaemia and, possibly, better cardiovascular and β-cell protection. The physician has now multiple choices to manage his/her patient after secondary failure of metformin, and the question whether it is preferable to add an oral dipeptidylpeptidase-4 (DPP-4) inhibitor (gliptin) or an injectable glucagon-like peptide-1 (GLP-1) receptor agonist will emerge. Obviously, DPP-4 inhibitors offer several advantages compared with GLP-1 receptor agonists, especia...

Dipeptidyl peptidase-4 (DPP-4) inhibitors are favourable to Glucagon-Like Peptide-1 (GLP-1) agonists: No.

European Journal of Internal Medicine — Fri, 03 Feb 2012 00:27:40 +0100

Authors: Madsbad S Abstract Incretin-based therapies, which include the GLP-1 receptor agonists and DPP-4 inhibitors, use the antidiabetic properties of potentiating the GLP-1 receptor signalling via the regulation of insulin and glucagon secretion, inhibition of gastric emptying and suppression of appetite. Most physicians will start antidiabetic treatment with metformin, but adding a GLP-1 receptor agonist as the second drug seems to be optimal since more patients will reach an HbA1c below 7% than with a DPP-4 inhibitor or another oral antidiabetic agents and with minimal risk of hypoglycaemia. The GLP-1 receptor agonists are also more effective in weight and systolic blood pressure control than DPP-4 inhibitors. The side effects of the GLP-1 receptor agonists are primarily nause...

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The association of physical activity with novel adipokines in patients with type 2 diabetes.

European Journal of Internal Medicine — Fri, 03 Feb 2012 00:27:31 +0100

CONCLUSIONS: Self-controlled physical activity of, even, moderate intensity ameliorates adipokines, such as visfatin, apelin and adiponectin, in patients with T2DM. Prospective interventional studies will confirm our results. The ClinicalTrials.gov identifier is: NCT00306176. PMID: 22284243 [PubMed - in process] (Source: European Journal of Internal Medicine)

Quality of life in type 2 diabetes mellitus after a very low calorie diet and exercise.

European Journal of Internal Medicine — Fri, 03 Feb 2012 00:27:21 +0100

CONCLUSION: A 16-week VLCD induces considerable weight loss, metabolic amelioration, and major improvements in QoL in obese T2DM patients. The addition of exercise is of paramount importance for the maintenance of better QoL. PMID: 22284244 [PubMed - in process] (Source: European Journal of Internal Medicine)

Erythrocyte mechanical fragility is increased in patients with type 2 diabetes.

European Journal of Internal Medicine — Fri, 03 Feb 2012 00:27:11 +0100

CONCLUSIONS: Our data suggest that patients with type 2 diabetes have a significantly higher erythrocyte mechanical fragility than matched nondiabetic subjects, and that fasting plasma glucose is the strongest correlate of increased mechanical fragility of erythrocytes in this patients group. PMID: 22284245 [PubMed - in process] (Source: European Journal of Internal Medicine)

Anemia as a risk factor for low bone mineral density in postmenopausal Turkish women.

European Journal of Internal Medicine — Fri, 03 Feb 2012 00:27:01 +0100

CONCLUSION: We have found that the presence of anemia was as an independent predictor of LBM for spine after adjusting for body mass index and other confounders in postmenopausal Turkish women. PMID: 22284246 [PubMed - in process] (Source: European Journal of Internal Medicine)

Quick diagnosis units or conventional hospitalisation for the diagnostic evaluation of severe anaemia: A paradigm shift in public health systems?

European Journal of Internal Medicine — Fri, 03 Feb 2012 00:26:51 +0100

CONCLUSIONS: For diagnostic purposes, patients with severe anaemia can be managed similarly in a QDU or in-hospital setting, but the QDU model is more cost-saving than traditional hospitalisation. Most QDU patients preferred the QDU model to hospital admission. PMID: 22284247 [PubMed - in process] (Source: European Journal of Internal Medicine)

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Comparison of levofloxacin-containing sequential and standard triple therapies for the eradication of Helicobacter pylori.

European Journal of Internal Medicine — Fri, 03 Feb 2012 00:26:41 +0100

CONCLUSION: The levofloxacin-containing sequential therapy is a significantly better strategy than the standard triple treatment for H. pylori eradication. Standard triple treatment is no more effective for H. pylori in our population and levofloxacin-containing sequential regimen might be used as a first-line eradication option. PMID: 22284248 [PubMed - in process] (Source: European Journal of Internal Medicine)

Growth differentiation factor-15, a novel biomarker related with disease severity in patients with hypertrophic cardiomyopathy.

European Journal of Internal Medicine — Fri, 03 Feb 2012 00:26:31 +0100

CONCLUSIONS: The present results show that higher levels of GDF-15 are associated to conditions of severe disease in HCM. Hence, GDF-15 is suggested as a novel marker related to the severity and could represent a further useful tool in monitoring functional capacity of HCM patients. PMID: 22284249 [PubMed - in process] (Source: European Journal of Internal Medicine)

Association between the polymorphism of estrogen receptor α and coronary artery disease in a Chinese population.

European Journal of Internal Medicine — Fri, 03 Feb 2012 00:26:22 +0100

CONCLUSIONS: The ERa PvuII polymorphism is associated with the increased risk of CAD in men of a Chinese population. Further research is needed to investigate the mechanism underlying the association between ERα polymorphism and CAD. PMID: 22284250 [PubMed - in process] (Source: European Journal of Internal Medicine)

Effects of renin-angiotensin blockers/inhibitors and statins on mortality and functional impairment in polypathological patients.

European Journal of Internal Medicine — Fri, 03 Feb 2012 00:26:12 +0100

CONCLUSIONS: The prescription of statins, alone or in combination with other drugs, may impact the survival and functional decline in polypathological patients. Further prospective blinded randomised assays are needed to confirm these observations. PMID: 22284251 [PubMed - in process] (Source: European Journal of Internal Medicine)

Routinely adding ultrasound examinations by pocket-sized ultrasound devices improves inpatient diagnostics in a medical department.

European Journal of Internal Medicine — Fri, 03 Feb 2012 00:26:02 +0100

CONCLUSION: By adding a pocket-sized ultrasound examination of <10min to usual care, we corrected the diagnosis in almost 1 of 5 patients admitted to a medical department, resulting in a completely different treatment strategy without delay in many of the patients. Routinely adding a cardiac and abdominal ultrasound screening has the potential to rearrange inpatients workflow and diagnosis. PMID: 22284252 [PubMed - in process] (Source: European Journal of Internal Medicine)

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An observational study on bloodstream extended-spectrum beta-lactamase infection in critical care unit: Incidence, risk factors and its impact on outcome.

European Journal of Internal Medicine — Fri, 03 Feb 2012 00:25:53 +0100

CONCLUSION: There is a high incidence of ESBL producing organisms causing blood stream infections in critically ill patients. Transfer from other hospitals and previous antibiotic usage are important risk factors for ESBL production. However ESBL production may not be associated with a poorer outcome if appropriate early antibiotic therapy is instituted. PMID: 22284253 [PubMed - in process] (Source: European Journal of Internal Medicine)

Serum osmolarity as an outcome predictor in hospital emergency medical admissions.

European Journal of Internal Medicine — Fri, 03 Feb 2012 00:25:42 +0100

CONCLUSION: Admission osmolarity, a simple calculation, is associated with the risk of mortality in acutely ill medical patients; deviations outside the normal range are relevant. A useful clinical predictive algorithm requires the incorporation of additional predictors. PMID: 22284254 [PubMed - in process] (Source: European Journal of Internal Medicine)

Prevalence of thoracic vertebral fractures in Spanish patients hospitalized in Internal Medicine Departments. Assessment of the clinical inertia. (PREFRAMI study).

European Journal of Internal Medicine — Fri, 03 Feb 2012 00:25:33 +0100

CONCLUSIONS: A high prevalence of asymptomatic VF is verified in medical inpatients ≥50years of age. The FRAX index did not turn out to be predictive of the presence of VF in this population. There is an underdiagnosis of osteoporotic VF in the coding at hospital discharge. Action protocols are necessary to avoid clinical inactivity regarding this entity. PMID: 22284255 [PubMed - in process] (Source: European Journal of Internal Medicine)

The prevalence of Neurally Mediated Syncope in older patients presenting with unexplained falls.

European Journal of Internal Medicine — Fri, 03 Feb 2012 00:25:23 +0100

CONCLUSION: Falls are unexplained in a significant number of older patients presenting to acute hospitals. The assessment of unexplained fallers for NMS is clinically important as this may be aetiologically related in nearly a quarter of these patients. PMID: 22284256 [PubMed - in process] (Source: European Journal of Internal Medicine)

Emergency visits and hospital admissions in aged people living close to a gas-fired power plant.

European Journal of Internal Medicine — Fri, 03 Feb 2012 00:25:12 +0100

DISCUSSION: Combustion of natural gas for energy generation produces a rise in air concentration of PM10 and NO(2) close to the plant, with a concentration-dependent increment of daily emergency visits and hospital admissions in elderly people, and with an age-dependent susceptibility. PMID: 22284257 [PubMed - in process] (Source: European Journal of Internal Medicine)

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Human papillomavirus detected in esophageal squamous cell carcinoma in Iran.

European Journal of Internal Medicine — Fri, 03 Feb 2012 00:25:02 +0100

CONCLUSION: In conclusion, the present study showed that a small proportion of ESCC specimens from Iran harbor HPV16, 18 genome using a highly sensitive method. As different rates have been reported from Iran, a more widespread study with more precise definition of geographical differences could delineate the potential involvement of HPV in the development of ESCC in Iranian population. PMID: 22284258 [PubMed - in process] (Source: European Journal of Internal Medicine)

Countering health threats by chemicals with a potential terrorist background - creating a rapid alert system for Europe.

European Journal of Internal Medicine — Fri, 03 Feb 2012 00:24:52 +0100

CONCLUSION: The RAS-CHEM database works and will be integrated into the Health Emergency Operations Facility (HEOF) with other European Rapid Alert Systems. Poisons centres receive a large number of enquiries and could be important sentinels in this field of toxicovigilance. PMID: 22284259 [PubMed - in process] (Source: European Journal of Internal Medicine)

Vitamin D deficiency and peripheral diabetic neuropathy.

European Journal of Internal Medicine — Fri, 03 Feb 2012 00:24:42 +0100

Authors: Skalli S, Muller M, Pradines S, Halimi S, Wion-Barbot N PMID: 22284260 [PubMed - in process] (Source: European Journal of Internal Medicine)

Vaccination against influenza a virus (H1N1) among Spanish healthcare workers.

European Journal of Internal Medicine — Fri, 03 Feb 2012 00:24:32 +0100

Authors: Olalla J, de Ory F, Casas I, Benítez N PMID: 22284261 [PubMed - in process] (Source: European Journal of Internal Medicine)

Initiation treatment with imiglucerase every 3weeks in type 1 Gaucher disease.

European Journal of Internal Medicine — Fri, 03 Feb 2012 00:24:22 +0100

Authors: Serratrice C, Swiader L, Serratrice J, Weiller PJ, Verrot D PMID: 22284262 [PubMed - in process] (Source: European Journal of Internal Medicine)

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Bed-blockers: An 8year experience of clinical management.

European Journal of Internal Medicine — Fri, 03 Feb 2012 00:24:12 +0100

Authors: Meschi T, Nouvenne A, Maggio M, Lauretani F, Borghi L PMID: 22284263 [PubMed - in process] (Source: European Journal of Internal Medicine)

Huge Increase of Calories in Cookbook Recipes

Psychology Today Food and Diet Center — Thu, 02 Feb 2012 21:41:21 +0100

By comparing cookbook recipes from 1936 and 2006, this helps us shed light (not weight) on one source of the obesity epidemic. read more (Source: Psychology Today Food and Diet Center)

Peritonitis in recent years: clinical findings and predictors of treatment response of 170 episodes at a single Brazilian center

International Urology and Nephrology — Thu, 02 Feb 2012 18:17:01 +0100

Conclusions The current clinical characteristics and outcome suggest a greater severity of peritonitis episodes and higher risk of death, possibly due to bacterial resistance. Older age is a risk factor for death. Content Type Journal ArticleCategory Nephrology – Original PaperPages 1-9DOI 10.1007/s11255-011-0107-7Authors Luiz Gustavo Oliveira, Department of Internal Medicine, Botucatu Medical School, Sao Paulo State University-UNESP, Botucatu, Sao Paulo 18618-970, BrazilJuliana Luengo, Department of Internal Medicine, Botucatu Medical School, Sao Paulo State University-UNESP, Botucatu, Sao Paulo 18618-970, BrazilJacqueline C. T. Caramori, Department of Internal Medicine, Botucatu Medical School, Sao Paulo State University-UNESP, Botucatu, Sao Paulo 18618-970, Braz...

Vocal characteristics in patients with type 2 diabetes mellitus

European Archives of Oto-Rhino-Laryngology — Thu, 02 Feb 2012 18:15:45 +0100

The objective of this study is to report the vocal characteristics of patients with type 2 diabetes mellitus in relation to disease duration, glycemic control, and neuropathy. This is a prospective study. The setting is institutional setting. A total of 82 patients were recruited for this study, and a healthy control group matched according to age and gender was recruited. Subjects underwent acoustic analysis and perceptual evaluation using the GRABS classification where G stands for grading, R for roughness, A for asthenia, B for breathiness, and S for straining using a scale of 0–3 where o stands for normal and three for severe deviation from normal. There was no significant difference in any of the acoustic variables between diabetic patients and control. There was no significan...

Factors Affecting Clinician Educator Encouragement of Routine HIV Testing Among Trainees

Journal of General Internal Medicine — Thu, 02 Feb 2012 18:15:12 +0100

CONCLUSIONS Clinician educators have a special role in the dissemination of the CDC recommendations as they impact the knowledge and attitudes of newly practicing physicians. Despite awareness of CDC recommendations, many CEs do not recommend universal HIV testing to trainees. Interventions that improve faculty knowledge of HIV testing recommendations and address barriers in resident clinics may enhance adoption of routine HIV testing. Content Type Journal ArticleCategory Original ResearchPages 1-6DOI 10.1007/s11606-012-1985-9Authors Gail V. Berkenblit, Department of Medicine, Johns Hopkins University School of Medicine, 601 North Caroline St., Baltimore, MD 21287, USAJames M. Sosman, Department of Medicine, University of Wisconsin School of Medicine and Public Hea...

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Polysomnography underestimates altered cardiac autonomic control in patients with obstructive sleep apnea

Herzschrittmachertherapie und Elektrophysiologie — Thu, 02 Feb 2012 18:14:29 +0100

Conclusion The effect of sleep-disordered breathing on alteration of autonomic tone in patients with hypopnea and obstructive apnea is more severe than estimated by conventional polysomnographic assessment of apnea and hypopnea. Patients with sleep apnea show a sympathetic overdrive not only during phases of hypopnea and obstructive apnea but also in non-apnea, non-hypopnea intervals before and after hypopnea, and obstructive apnea. Content Type Journal ArticleCategory Original ContributionPages 1-7DOI 10.1007/s00399-012-0166-1Authors C. Jilek, Clinic and Policlinic of Internal Medicine II, University Hospital Regensburg, Regensburg, GermanyJ. Gebauer, Clinic and Policlinic of Internal Medicine II, University Hospital Regensburg, Regensburg, GermanyF. Muders, Clini...

Attitudes Toward Hepatitis B Virus among Vietnamese, Chinese and Korean Americans in the Houston Area, Texas

Journal of Community Health — Thu, 02 Feb 2012 18:14:01 +0100

Abstract We explored attitudes about prevention, screening and treatment of hepatitis B virus (HBV) infection in Chinese, Korean and Vietnamese communities. We use qualitative methods in 12 focus groups (n = 113) of adults who self-reported their ethnicity to be Chinese, Korean, or Vietnamese. We use grounded theory (i.e., consensus-building between co-coders about recurring, emerging themes) for analysis. Diet, nutrition, fatigue and stress were misidentified as HBV causes. Improving hygiene, diet, exercise, and holistic methods were misidentified as viable HBV prevention methods. Common screening problems included not affording test and not understanding test results. Participants shared reasons for using complementary and alternative medicine—when Western me...

A phase II trial of Erlotinib in combination with gemcitabine and cisplatin in advanced pancreatic cancer

Investigational New Drugs — Thu, 02 Feb 2012 18:12:11 +0100

Conclusion The triple regimen of GPT is effective for APC. Treatment-related mortalities factored early closure of this GPT protocol. Considering effect and toxicity, this triple regimen seems to offer few benefits to the patients compared with gemcitabine-based doublets. (ClinicalTrials.gov number, NCT00922896). Content Type Journal ArticleCategory PHASE II STUDIESPages 1-6DOI 10.1007/s10637-012-9792-zAuthors In Gyu Hwang, Department of Internal Medicine, Chung-Ang University College of Medicine, 224 Heukseok-dong, Dongjak-gu, Seoul 156-755, Republic of KoreaJoung-Soon Jang, Department of Internal Medicine, Chung-Ang University College of Medicine, 224 Heukseok-dong, Dongjak-gu, Seoul 156-755, Republic of KoreaSung Yong Oh, Department of Medicine, Dong-A University College of Med...

An explorative analysis of secretory receptor for advanced glycation endproducts in primary focal segmental glomerulosclerosis

Clinical and Experimental Nephrology — Thu, 02 Feb 2012 18:12:08 +0100

Conclusion This study showed that only the serum level of esRAGE, not sRAGE, was higher in the FSGS group than in the IgAN and control groups. The amount of 24-h proteinuria was also related to the serum level of esRAGE in the FSGS group. Content Type Journal ArticleCategory Original ArticlePages 1-7DOI 10.1007/s10157-012-0599-1Authors Harin Rhee, Division of Nephrology, Department of Internal Medicine, Pusan National University School of Medicine, 179 Gudeok-ro, Seo-gu, Busan, 602-739 Republic of KoreaSang Heon Song, Division of Nephrology, Department of Internal Medicine, Pusan National University School of Medicine, 179 Gudeok-ro, Seo-gu, Busan, 602-739 Republic of KoreaIhm Soo Kwak, Division of Nephrology, Department of Internal Medicine, Pusan National Universit...

Liver Stiffness Measurement Using Acoustic Radiation Force Impulse (ARFI) Elastography and Effect of Necroinflammation

Digestive Diseases and Sciences — Thu, 02 Feb 2012 18:09:15 +0100

Conclusions ARFI elastography is a reliable surrogate marker of liver fibrosis, if its relationship with biochemical markers, for example ALT level, is taken into account. Content Type Journal ArticleCategory Original ArticlePages 1-10DOI 10.1007/s10620-012-2044-4Authors Ki Tae Yoon, Department of Internal Medicine, Pusan National University School of Medicine, Yangsan, KoreaSun Min Lim, Department of Internal Medicine, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun–gu, Seoul, 120–752 KoreaJun Yong Park, Department of Internal Medicine, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun–gu, Seoul, 120–752 KoreaDo Young Kim, Department of Internal Medicine, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun–gu, S...

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Clinical and radiographic results from a 2-year comparison of once-weekly versus twice-weekly administration of etanercept in biologics-naive patients with rheumatoid arthritis

Modern Rheumatology — Thu, 02 Feb 2012 18:08:29 +0100

Conclusions These results suggest that, in terms of DAS-28 remission, OW therapy can efficiently substitute for TW therapy in biologics-naive patients with RA. However, TW therapy was indispensable in preventing the worsening of joint damage. Content Type Journal ArticleCategory Original ArticlePages 1-7DOI 10.1007/s10165-011-0591-8Authors Takahiko Wada, Department of Orthopaedic Surgery, Hirakata Hospital, Kansai Medical University, 2-3-1 Shin-machi, Hirakata, Osaka 573-1191, JapanYonsu Son, Department of Rheumatology, Hirakata Hospital, Kansai Medical University, 2-3-1 Shin-machi, Hirakata, Osaka 573-1191, JapanYoshiro Ozaki, Department of Rheumatology, Hirakata Hospital, Kansai Medical University, 2-3-1 Shin-machi, Hirakata, Osaka 573-1191, JapanShosaku Nomura, De...

Treatment for vitamin D deficiency: here and there do not mean everywhere

European Journal of Nutrition — Thu, 02 Feb 2012 17:57:47 +0100

Content Type Journal ArticleCategory Letter to the EditorPages 1-3DOI 10.1007/s00394-012-0316-6Authors Pietro Ameri, Department of Internal Medicine, University of Genova, Viale Benedetto XV, 6, 16132 Genova, ItalyMarta Bovio, Department of Internal Medicine, University of Genova, Viale Benedetto XV, 6, 16132 Genova, ItalyGiovanni Murialdo, Department of Internal Medicine, University of Genova, Viale Benedetto XV, 6, 16132 Genova, Italy Journal European Journal of NutritionOnline ISSN 1436-6215Print ISSN 1436-6207 (Source: European Journal of Nutrition)

Association of Thr420Lys polymorphism in DBP gene with fat-soluble vitamins and low radial bone mineral density in postmenopausal Thai women

Future Medicine: Biomarkers in Medicine — Thu, 02 Feb 2012 10:45:05 +0100

Biomarkers in Medicine , February 2012, Vol. 6, No. 1, Pages 103-108. (Source: Future Medicine: Biomarkers in Medicine)

Genetic variation of IL-12B (+1188 region) is associated with its decreased circulating levels and susceptibility to Type 2 diabetes

Future Medicine: Biomarkers in Medicine — Thu, 02 Feb 2012 10:45:02 +0100

Biomarkers in Medicine , February 2012, Vol. 6, No. 1, Pages 89-95. (Source: Future Medicine: Biomarkers in Medicine)