MedWorm: Medicine (General)

DDM - An Attitude of Excellence: How to Succeed at Work and at Home (NIH Only)

Videocast - All Events — Fri, 20 Nov 2009 14:21:00 +0100

2008-2009 Deputy Director for Management (DDM) Seminar Series The DDM Seminar Series is open to all NIH employees and there is no need to pre-register for the event. http://www.ddmseries.od.nih.govAir date: 12/3/2009 11:00:00 AM (Source: Videocast - All Events)

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Pap tests used more often then screening guidelines call for

American Medical News — Fri, 20 Nov 2009 14:06:05 +0100

Researchers say patient demand for the test and lag time between revisions to screening recommendations and implementation may be reasons for overuse. (Source: American Medical News)

Physicians sue again to safeguard Pennsylvania's liability fund

American Medical News — Fri, 20 Nov 2009 14:06:05 +0100

Doctors say the $100 million the governor took from Mcare to balance the state budget is needed to cover outstanding liability claims. (Source: American Medical News)

Health research in developing countries

BMJ Online First — Fri, 20 Nov 2009 11:32:26 +0100

(Source: BMJ Online First)

Investigation of incidental hypercalcaemia

BMJ Online First — Fri, 20 Nov 2009 11:32:26 +0100

(Source: BMJ Online First)

Google study: How physicians use the internet and search in their clinical practices

Clinical Cases and Images — Fri, 20 Nov 2009 11:10:00 +0100

Embedded PDF: Google study: How physicians use the internet and search in their clinical practices.Link via IgniteBLOG.@amcunningham points out that the report is "unfortunately research carried out as market research for Google and doesn't help #meded very much." Posted at Clinical Cases and Images. Stay updated and subscribe, or follow me on Twitter. (Source: Clinical Cases and Images)

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Listen to The Lancet: 21 November

Listen to The Lancet — Fri, 20 Nov 2009 10:30:00 +0100

Discussion of the potential of stem cells to produce skin epidermis. (Source: Listen to The Lancet)

The economic impact of pandemic influenza

BMJ Online First — Fri, 20 Nov 2009 00:10:23 +0100

(Source: BMJ Online First)

The economy-wide impact of pandemic influenza on the UK: a computable general equilibrium modelling experiment

BMJ Online First — Fri, 20 Nov 2009 00:10:23 +0100

Conclusion Balancing school closure against "business as usual" and obtaining sufficient stocks of effective vaccine are more important factors in determining the economic impact of an influenza pandemic than is the disease itself. Prophylactic absence from work in response to fear of infection can add considerably to the economic impact. (Source: BMJ Online First)

Predicting risk of osteoporotic fracture in men and women in England and Wales: prospective derivation and validation of QFractureScores

BMJ Online First — Fri, 20 Nov 2009 00:10:23 +0100

Conclusions These new algorithms can predict risk of fracture in primary care populations in the UK without laboratory measurements and are therefore suitable for use in both clinical settings and for self assessment (www.qfracture.org). QFractureScores could be used to identify patients at high risk of fracture who might benefit from interventions to reduce their risk. (Source: BMJ Online First)

Study Provides Insight Into Bone-Overgrowth Disease

Modern Medicine — Fri, 20 Nov 2009 00:00:00 +0100

In patients with fibrodysplasia ossificans progressiva, a mutation in the ACVR1 receptor appears to promote cartilage formation by inducing bone morphogenetic protein signaling, according to research published in the November issue of the Journal of Clinical Investigation. (Source: Modern Medicine)

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WHO officials try to allay fears about vaccine adverse effects

MD Consult: News: Top Stories — Fri, 20 Nov 2009 00:00:00 +0100

Read the full story on MD Consult: WHO officials try to allay fears about vaccine adverse effects (Source: MD Consult: News: Top Stories)

New Yorkers can obtain influenza information by dialing 311

MD Consult: News: Top Stories — Fri, 20 Nov 2009 00:00:00 +0100

Read the full story on MD Consult: New Yorkers can obtain influenza information by dialing 311 (Source: MD Consult: News: Top Stories)

H1N1 vaccine is safe, according to multiagency monitoring

MD Consult: News: Top Stories — Fri, 20 Nov 2009 00:00:00 +0100

Read the full story on MD Consult: H1N1 vaccine is safe, according to multiagency monitoring (Source: MD Consult: News: Top Stories)

Adjuvant vaccines could have helped prevent H1N1 shortfall, drug manufacturers claim

MD Consult: News: Top Stories — Fri, 20 Nov 2009 00:00:00 +0100

Read the full story on MD Consult: Adjuvant vaccines could have helped prevent H1N1 shortfall, drug manufacturers claim (Source: MD Consult: News: Top Stories)

Diagnostic role of whole body bone scintigraphy in atypical skeletal tuberculosis resembling multiple metastases: a case report

BioMed Central — Fri, 20 Nov 2009 00:00:00 +0100

Conclusion: Scintigraphic bone scanning should be kept in mind when assessing bone pain in patients at a high risk of tuberculosis infection or reactivation. We present this unusual case of multifocal skeletal tuberculosis, and stress the related clinical and diagnostic points with the aim of stimulating a high index of suspicion that could facilitate early diagnosis and appropriate treatment. (Source: BioMed Central)

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Ancestry-related assortative mating in latino populations

BioMed Central — Fri, 20 Nov 2009 00:00:00 +0100

Conclusions: Assortative mating related to genetic ancestry persists in Latino populations to the current day, and has impacted on the genomic structure in these populations. (Source: BioMed Central)

De novo 454 sequencing of barcoded BAC pools for comprehensive gene survey and genome analysis in the complex genome of barley

BioMed Central — Fri, 20 Nov 2009 00:00:00 +0100

Conclusions: The described multiplex 454 sequencing of barcoded BACs leads to sequence consensi highly representative for the clones. Assemblies are correct for the majority of contigs. Though the resolution of complex repetitive structures requires additional experimental efforts, our approach paves the way for a clone based strategy of sequencing the barley genome. (Source: BioMed Central)

COMIT: Identification of noncoding motifs under selection in coding sequences

BioMed Central — Fri, 20 Nov 2009 00:00:00 +0100

We present the COMIT algorithm to detect functional noncoding motifs in coding regions using sequence conservation, explicitly separating nucleotide from amino acid effects. COMIT concurs with diverse experimental datasets, including splicing enhancers, silencers, replication motifs, and microRNA targets, and predicts many novel functional motifs. Intriguingly, COMIT scores are well-correlated to scores uncalibrated for amino acids, suggesting that nucleotide motifs often override peptide-level constraints. (Source: BioMed Central)

Characterisation of microRNA expression in post-natal mouse mammary gland development

BioMed Central — Fri, 20 Nov 2009 00:00:00 +0100

Conclusions: MicroRNAs were expressed in likely co-regulated clusters during mammary gland development. Breast cancer-associated miRNAs were significantly enriched in these clusters. The mechanism and functional consequences of this miRNA co-regulation provide new avenues for research into mammary gland biology and generate candidates for functional validation. (Source: BioMed Central)

Searching for SNPs with cloud computing

BioMed Central — Fri, 20 Nov 2009 00:00:00 +0100

As DNA sequencing outpaces improvements in computer speed, there is a critical need to accelerate tasks like alignment and SNP calling. Crossbow is a cloud-computing software tool that combines the aligner Bowtie and the SNP caller SOAPsnp. Executing in parallel using Hadoop, Crossbow analyzes data comprising 38-fold coverage of the human genome in three hours using a 320-CPU cluster rented from a cloud computing service for about $85. Crossbow is available from http://bowtie-bio.sf.net/crossbow. (Source: BioMed Central)

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Partial loss of heterozygosity events at the mutated gene in tumors from MLH1/MSH2 large genomic rearrangement carriers

BioMed Central — Fri, 20 Nov 2009 00:00:00 +0100

Conclusion: LGRs accounted for 25% of germline MMR mutations identified in 28 Slovakian HNPCC families. A high frequency of LGRs among the MSH2 mutations provides a rationale for a MLPA screening of the Slovakian HNPCC families prior scanning by DNA sequencing. LOH at part of the informative loci confined to the MLH1 or MSH2 gene (heterozygous LGR region, SNP, or microsatellite) is a novel finding and can be regarded as a partial LOH. The conversion begins within the gene, and the details of conversion tracts are discussed for each case. (Source: BioMed Central)

The politics of local hospital reform: a case study of hospital reorganization following the 2002 Norwegian hospital reform

BMC Health Services Research — Fri, 20 Nov 2009 00:00:00 +0100

Conclusion: Because of the incentives that faced political actors and the controversial nature of major hospital reforms, the removal of local politicians and the centralization of ownership did not necessarily facilitate reforms in the hospital structure. Keeping politics at an arm's length may simply be unrealistic and further complicate the politics of local hospital reforms. (Source: BMC Health Services Research)

Predicting intention to treat HIV-infected patients among Tanzanian and Sudanese medical and dental students using the theory of planned behaviour-a cross sectional study

BMC Health Services Research — Fri, 20 Nov 2009 00:00:00 +0100

Conclusion: The TPB is applicable to students' care delivery intentions in the context of HIV and AIDS across the two SSA countries investigated. It is suggested that attitudes, subjective norms, moral norms and perceived behavioural control are key factors in students' willingness to treat AIDS and HIV infected patients and should be targets of interventions aimed at promoting quality health care delivery in this context. (Source: BMC Health Services Research)

[Case Report] Two red eyes and one asymptomatic donor