MedWorm: Lipidology Top 20

VLDL cholesterol predicts coronary risk in Chinese population

MedWire News - Lipidology — Fri, 26 Feb 2010 16:53:46 +0100

Elevated levels of very-low-density lipoprotein cholesterol increase the risk for coronary heart disease in Chinese people, a large study has found. (Source: MedWire News - Lipidology)

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[Research Articles] Structural characterization of Bordetella parapertussis lipid A

The Journal of Lipid Research — Tue, 07 Apr 2009 04:00:00 +0100

Bordetella parapertussis like B. pertussis, is a causal agent of whooping cough but is not a strictly human pathogen. Because its endotoxin, a major structural component of the Gram-negative outer membrane, is an important virulence factor, we have analyzed the structure of its toxic lipid domain, in one rough and two smooth bacterial strains. Chemical analyses and mass spectra obtained before and after recently developed mild-alkali treatments revealed that the lipids A have the common bisphosphorylated β-(1->6)-linked D-glucosamine disaccharide with hydroxytetradecanoic acid in amide linkages. All three strains have two major molecular species: a tetraacyl and a pentaacyl species. The rough strain is richer in a minor hexaacyl species. Acylation at the C-2, C-3, and C-3' position...

Structural characterization of Bordetella parapertussis lipid A [Research Articles]

The Journal of Lipid Research — Mon, 06 Apr 2009 23:00:00 +0100

Blood lipids, homocisteine, stress factors, and vitamins in clinically stable multiple sclerosis patients

Lipids in Health and Disease — Thu, 18 Feb 2010 00:00:00 +0100

In conclusion, modifications of some biochemical markers of cell damage were detected in MS patients during a phase of clinical inactivity. (Source: Lipids in Health and Disease)

Brucella infection linked with atherogenic lipid profile

MedWire News - Lipidology — Thu, 25 Jun 2009 00:00:00 +0100

Acute infection with Brucella melitensis is associated with an atherogenic lipid profile that remains several months after treatment for the bacterium, a Greek study suggests. (Source: MedWire News - Lipidology)

Insulin resistance may enhance statin response

MedWire News - Lipidology — Thu, 04 Mar 2010 18:46:01 +0100

Insulin resistance is associated with an enhanced response to statin therapy, research suggests. (Source: MedWire News - Lipidology)

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Ezetimibe has multiple effects beyond lipid-lowering

MedWire News - Lipidology — Tue, 23 Feb 2010 17:08:00 +0100

The lipid-lowering drug ezetimibe has a wide range of beneficial effects on metabolic, oxidative, inflammatory, and renal parameters, a Japanese study has demonstrated. (Source: MedWire News - Lipidology)

The use of LeptiCore in reducing fat gain and managing weight loss in patients with metabolic syndrome

Lipids in Health and Disease — Fri, 19 Feb 2010 00:00:00 +0100

Conclusion: The LeptiCore formulation at both the low and high dosages appears to be helpful in the management of fat gain and its related complications. The higher dosage resulted in significantly greater reductions in body weight and triglyceride, blood glucose, and C-reactive protein levels, as well as increased serotonin levels. (Source: Lipids in Health and Disease)

NPC1L1 inhibitor ezetimibe is a reliable therapeutic agent for non-obese patients with nonalcoholic fatty liver disease

Lipids in Health and Disease — Fri, 12 Mar 2010 00:00:00 +0100

Background: We recently examined the distribution of abdominal fat, dietary intake and biochemical data in patients with nonalcoholic fatty liver disease (NAFLD) and found that non-obese NAFLD patients did not necessarily exhibit insulin resistance and/or dysregulated secretion of adipocytokines. However, dietary cholesterol intake was superabundant in non-obese patients compared with obese patients, although total energy and carbohydrate intake was not excessive. Therefore, excess cholesterol intake appears to be one of the main factors associated with NAFLD development and liver injury. Methods: We reviewed a year of follow-up data of non-obese NAFLD patients treated with Niemann-Pick C1 like 1 inhibitor ezetimibe to evaluate its therapeutic effect on clinical parameters related to NAFLD...

Adipose triglyceride lipase plays a key role in the supply of the working muscle with fatty acids [Research Articles]

The Journal of Lipid Research — Mon, 15 Feb 2010 19:50:12 +0100

In this study, we investigated the effect of moderate treadmill exercise on blood energy metabolites and liver glycogen stores in mice lacking ATGL. Because ATGL-ko mice exhibit massive accumulation of TG in the heart and cardiomyopathy, we also investigated a mouse model lacking ATGL in all tissues except cardiac muscle (ATGL-ko/CM). In contrast to ATGL-ko mice, these mice did not accumulate TG in the heart and had normal life expectancy. Exercise experiments revealed that ATGL-ko and ATGL-ko/CM mice are unable to increase circulating FA levels during exercise. The reduced availability of FA for energy conversion led to rapid depletion of liver glycogen stores and hypoglycemia. Together, our studies suggest that ATGL-ko mice cannot adjust circulating FA levels to the increased energy requ...

Further development of taranabant stopped due to adverse effects

MedWire News - Lipidology — Thu, 18 Feb 2010 16:43:49 +0100

Results from a phase III study of the cannabinoid-1 receptor agonist taranabant show that despite its efficacy for weight loss, the number and degree of reported adverse effects do not support its further development to treat obesity. (Source: MedWire News - Lipidology)

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Niacin has vascular benefits ‘beyond lipid lowering’

MedWire News - Lipidology — Mon, 01 Mar 2010 00:00:00 +0100

Niacin inhibits vascular inflammation and improves endothelial function, independently of its lipid-lowering effects, a study in rabbits has found. (Source: MedWire News - Lipidology)

Isoprostane levels high, increase with metabolic complications in obese children

MedWire News - Lipidology — Tue, 23 Feb 2010 00:00:00 +0100

Results show that serum concentration of isoprostane, a marker of oxidative stress, is high in obese children and goes up further with increasing number of metabolic complications. (Source: MedWire News - Lipidology)

Severe hypertriglyceridemia linked with excess CHD, stroke mortality

MedWire News - Lipidology — Mon, 15 Mar 2010 00:00:00 +0100

Severe hypertriglyceridemia is associated with a markedly increased risk for coronary heart disease and stroke mortality, even in the absence of diabetes, a UK study shows. (Source: MedWire News - Lipidology)

ACCORD lipid: Fibrates do not improve CV outcomes in diabetic patients taking statins

MedWire News - Lipidology — Mon, 15 Mar 2010 16:58:39 +0100

Combination therapy with fenofibrate and simvastatin does not provide additional protection against cardiovascular disease in high-risk patients with Type 2 diabetes compared with simvastatin alone, according to findings from the ACCORD lipid trial. (Source: MedWire News - Lipidology)

CETP variant associated with variable cholesterol response to statin therapy

MedWire News - Lipidology — Wed, 03 Mar 2010 16:58:36 +0100

Variants in the cholesteryl ester transfer protein gene and in the apolipoprotein A-I gene are associated with poor cholesterol-lowering response to statins in an elderly population, report researchers. (Source: MedWire News - Lipidology)

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Statin primary prevention efficacy ‘equivalent in women and men’

MedWire News - Lipidology — Tue, 02 Mar 2010 18:01:32 +0100

Statins are effective for the primary prevention of cardiovascular disease events in women, shows a gender-specific analysis of the JUPITER trial and an updated meta-analysis of relevant trials. (Source: MedWire News - Lipidology)

Influence of co-existing atrial fibrillation on the efficacy of atorvastatin treatment in patients with dilated cardiomyopathy: a pilot study

Lipids in Health and Disease — Tue, 23 Feb 2010 00:00:00 +0100

Conclusion: In patients with DCM and co-existing AF, a weaker effect of atorvastatin concerning the reduction of IL-6 and NT-proBNP concentration was observed than in patients without atrial fibrillation. (ClinialTrial.gov No.: NCT01015144) (Source: Lipids in Health and Disease)

Lifestyle intervention better than metformin for lowering obesity in young women

MedWire News - Lipidology — Wed, 17 Feb 2010 00:00:00 +0100

An intensive lifestyle intervention program is more effective for promoting weight loss in young women than treatment with metformin, show study results. (Source: MedWire News - Lipidology)

Adiponectin downregulation implicated in heart failure

MedWire News - Lipidology — Tue, 09 Mar 2010 00:00:00 +0100

Levels of adiponectin are reduced in patients with both dilated cardiomyopathy and impaired coronary function, study findings show. (Source: MedWire News - Lipidology)