MedWorm: Lipidology Top 20

Visceral body fat risk factor for all-cause, obesity-related mortality

MedWire News - Lipidology — Wed, 11 Jan 2012 12:07:36 +0100

Visceral body fat is associated with all-cause and obesity-related mortality in Japanese Americans, independent of waist circumference, study results show. (Source: MedWire News - Lipidology)

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Virgin olive oil in preventive medicine: from legend to epigenetics

European Journal of Lipid Science and Technology — Mon, 16 Jan 2012 05:00:00 +0100

AbstractSummary: Among vegetable oils, Extra virgin olive oil (EVOO) has nutritional and sensory characteristics that make it unique and a basic component of the Mediterranean diet. EVOO has always been used over the centuries for its preventive and therapeutic properties, as well as precious and valuable dietary lipidic condiment. Benefic effects of a diet rich in EVOO on the human health, especially in prevention and/or reduction of hypercholesterolaemia, serum lipoprotein levels and atherosclerosis, hypertension, cardiovascular diseases and thrombotic risk, oxidation and oxidative stress, obesity and type 2 diabetes, inflammatory processes and cancer are discussed in these review. Recent studies suggest also its role in regulating the sense of satiety. The chemical compounds of EVOO tha...

Hip and waist circumference ‘should be included in CVD risk prediction models’

MedWire News - Lipidology — Wed, 01 Feb 2012 06:44:59 +0100

The effect of central obesity on mortality risk may be significantly underestimated without adjustment for hip circumference, suggest study results. (Source: MedWire News - Lipidology)

Parents considered as ‘agents of change’ in childhood obesity

MedWire News - Lipidology — Wed, 25 Jan 2012 12:28:56 +0100

Parents and adult caregivers of obese children should be considered as “agents of change,” according to a scientific statement from the American Heart Association. (Source: MedWire News - Lipidology)

Adipose tissue stem cells meet preadipocyte commitment: going back to the future [Reviews]

The Journal of Lipid Research — Mon, 09 Jan 2012 05:00:00 +0100

White adipose tissue (WAT) is perhaps the most plastic organ in the body, capable of regeneration following surgical removal and massive expansion or contraction in response to altered energy balance. Research conducted for over 70 years has investigated adipose tissue plasticity on a cellular level, spurred on by the increasing burden that obesity and associated diseases are placing on public health globally. This work has identified committed preadipocytes in the stromal vascular fraction of adipose tissue and led to our current understanding that adipogenesis is important not only for WAT expansion, but also for maintenance of adipocyte numbers under normal metabolic states. At the turn of the millenium, studies investigating preadipocyte differentiation collided with developments in st...

Premenopausal gender-related atheroprotective effect offset early in menopausal life

MedWire News - Lipidology — Mon, 16 Jan 2012 13:38:46 +0100

Recently postmenopausal women have the same prevalence of subclinical carotid atherosclerosis as age- and traditional risk factor-matched men, report researchers. (Source: MedWire News - Lipidology)

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Simultaneous quantification of serum phytosterols and cholesterol precursors using a simple gas chromatographic method

European Journal of Lipid Science and Technology — Mon, 16 Jan 2012 05:00:00 +0100

AbstractSummary: Determination of the main phytosterols (β‐sitosterol and campesterol) and cholesterol precursors (desmosterol and lathosterol) in human serum using a simple gas chromatography‐flame ionization detector (GC‐FID) method has been validated. Direct saponification, without lipid extraction, sterols extraction and further derivatization was applied to samples prior to GC analysis. To evaluate the method, a pool of serum samples from 8 healthy women was used. Good linearity (r > 0.99) was found in the assay range: β‐sitosterol (0.99‐17.82 µg/mL), campesterol (0.14‐10.8 µg/mL), desmosterol (0.17‐2.6 µg/mL), and lathosterol (0.6‐5.97 µg/mL). Limits of detection (LOD) (ng/mL) were: 86 (β‐sitosterol), 42 (campesterol), 4 (desmosterol), 44 (lath...

Carotid plaque burden is strong predictor of cardiac death in CAD

MedWire News - Lipidology — Mon, 09 Jan 2012 00:00:00 +0100

Ultrasound-detected carotid plaque is a strong predictor of cardiac death, myocardial infarction, and stroke in patients with coronary artery disease, study results show. (Source: MedWire News - Lipidology)

Obesity prevalence still high in the US, but may be leveling off

MedWire News - Lipidology — Thu, 19 Jan 2012 10:49:43 +0100

The prevalence of obesity among US adults, children, and adolescents is still high, but has changed little in recent years, report researchers. (Source: MedWire News - Lipidology)

Rare LPL gene variants common in hypertriglyceridemia

MedWire News - Lipidology — Wed, 22 Dec 2010 00:00:00 +0100

Rare variants in the lipoprotein lipase gene are highly prevalent in people with hypertriglyceridemia but uncommon in Type III hyperlipidemia, a German team has found. (Source: MedWire News - Lipidology)

Weight has U-shaped association with AMI mortality

MedWire News - Lipidology — Tue, 21 Dec 2010 00:00:00 +0100

Body weight is associated with mortality following acute myocardial infarction, with both underweight and overweight conferring an increased risk, reports an Israeli team. (Source: MedWire News - Lipidology)

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Unhealthy behaviors identified in obese 12-year-olds

MedWire News - Lipidology — Mon, 20 Dec 2010 00:00:00 +0100

A survey of US 12-year-olds had found that 15% are obese and that obese children typically display adverse cardiovascular risk profiles. (Source: MedWire News - Lipidology)

Early liver, heart damage found in children with metabolic syndrome

MedWire News - Lipidology — Thu, 23 Dec 2010 00:00:00 +0100

Children with the metabolic syndrome are at increased risk for preclinical manifestations of liver and cardiac damage, Italian researchers have shown. (Source: MedWire News - Lipidology)

HDL levels improve after smoking cessation

MedWire News - Lipidology — Mon, 20 Dec 2010 14:29:00 +0100

Stopping smoking is associated with an improvement in high-density lipoprotein levels, particularly in women, research reveals. (Source: MedWire News - Lipidology)

Fenofibrate therapy reduces burden of oxidative stress

MedWire News - Lipidology — Thu, 23 Dec 2010 05:16:47 +0100

Treatment with fenofibrate leads to a reduction in biomarkers of oxidative stress, US researchers have shown. (Source: MedWire News - Lipidology)

Low leptin levels increase CV risk

MedWire News - Lipidology — Mon, 13 Dec 2010 00:00:00 +0100

Low leptin levels are associated with increased cardiovascular events and mortality in patients with stable coronary artery disease, shows an analysis of The Heart and Soul Study. (Source: MedWire News - Lipidology)

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Characteristics of lipoprotein subclass particles differ depending on country of residence

MedWire News - Lipidology — Fri, 17 Dec 2010 00:00:00 +0100

Study results show that the size and concentration of very low-density lipoprotein, low-density lipoprotein, and high-density lipoprotein subclass particles differs significantly between ethnic Japanese growing up in different countries. (Source: MedWire News - Lipidology)

FABP4/aP2 expression linked to carotid plaque instability

MedWire News - Lipidology — Fri, 10 Dec 2010 02:06:02 +0100

Swedish researchers suggest that increased expression of fatty acid-binding protein 4/aP2 in atherosclerotic plaques is a risk factor for unstable carotid vascular disease. (Source: MedWire News - Lipidology)

Statin pretreatment improves CRP levels and myocardial perfusion in STEMI patients

MedWire News - Lipidology — Tue, 14 Dec 2010 00:00:00 +0100

Turkish researchers show that long-term statin pretreatment in patients with acute ST-segment elevation myocardial infarctions is associated with lower C-reactive protein levels on admission and better myocardial perfusion after primary percutaneous coronary intervention. (Source: MedWire News - Lipidology)

MI risk increased by triglyceride-associated SNP

MedWire News - Lipidology — Wed, 15 Dec 2010 00:00:00 +0100

A single nucleotide polymorphism in a gene associated with higher fasting triglyceride levels increases the risk for early-onset myocardial infarction, independently of triglyceride levels, Italian scientists have discovered. (Source: MedWire News - Lipidology)