MedWorm: Neurology Top 20

Serotonin syndrome after administration of milnacipran for fibromyalgia

Neurology — Mon, 22 Feb 2010 21:01:07 +0100

(Source: Neurology)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Cognitive effects of pregabalin in healthy volunteers: A double-blind, placebo-controlled trial

Neurology — Mon, 01 Mar 2010 21:00:04 +0100

Conclusion: At conventional doses and titration, pregabalin induced mild negative cognitive effects and neurotoxicity complaints in healthy volunteers. These effects are one factor to be considered in the selection and monitoring of chronic AED therapy. Class of Evidence: This study provides Class I evidence that pregabalin 300 mg BID negatively impacts cognition on some tasks in healthy volunteers. (Source: Neurology)

Electronic Medical Records as a Research Tool: Evaluating Topiramate Use at a Headache Center

Headache: The Journal of Head and Face Pain — Fri, 05 Mar 2010 00:00:00 +0100

Conclusions.[mdash] Findings from our study using EMR demonstrate that physicians use topiramate at many different doses and for many off-label indications. This analysis provided important insight into our patient populations and treatment patterns. (Headache 2010;[bull][bull]:[bull][bull]-[bull][bull]) (Source: Headache: The Journal of Head and Face Pain)

Word length and word frequency affect eye movements in dyslexic children reading in a regular (German) orthography.

Annals of Dyslexia — Fri, 12 Mar 2010 00:00:00 +0100

Authors: Dürrwächter U, Sokolov AN, Reinhard J, Klosinski G, Trauzettel-Klosinski S We combined independently the word length and word frequency to examine if the difficulty of reading material affects eye movements in readers of German, which has high orthographic regularity, comparing the outcome with previous findings available in other languages. Sixteen carefully selected German-speaking dyslexic children (mean age, 9.5 years) and 16 age-matched controls read aloud four lists, each comprising ten unrelated words. The lists varied orthogonally in word length and word frequency: high-frequency, short; high-frequency, long; low-frequency, short; low-frequency, long. Eye movements were measured using a scanning laser ophthalmoscope (SLO). In dyslexic children, fixation durat...

Timing of Symptomatic Vasospasm in Aneurysmal Subarachnoid Hemorrhage: The Effect of Treatment Modality and Clinical Implications

Journal of Stroke and Cerebrovascular Diseases — Sat, 27 Feb 2010 14:45:56 +0100

A better prediction of the time course of symptomatic vasospasm (SVSP) might have a significant impact on the management and prevention of delayed neurologic ischemic deficit (DIND). We studied the influence of the treatment for ruptured aneurysm on SVSP timing. We retrospectively analyzed data of consecutive patients with aneuysmal subarachnoid hemorrhage (aSAH) admitted in our center between 1999 and 2005, treated within 72 hours of the rupture by surgical clipping or endovascular coiling and in accordance with our neuroscience unit protocol. We analyzed the presence of SVSP and recorded the timing of occurrence after the aneurysmal repair intervention. Data on demographics, premorbid conditions, time elapsed from the subarachnoid hemorrhage onset and intervention, and clinical and radio...

Groundbreaking Study Using Ultrasound For The Treatment Of Intracerebral And Intraventricular Hemorrhage Stroke Shows Promise

Stroke / Neuroprotection News From Medical News Today — Sat, 27 Feb 2010 09:00:00 +0100

David Newell, M.D., co-executive director of the Swedish Neuroscience Institute (SNI) in Seattle presented results of a groundbreaking study of 33 patients with spontaneous intracerebral hemorrhage who were screened for inclusion in a SNI clinical study known as 'SLEUTH' (Safety of Lysis with Ultrasound in the Treatment of Intracerebral and Intraventricular Hemorrhage)... (Source: Stroke / Neuroprotection News From Medical News Today)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Antibiotic responsive demyelinating neuropathy related to lyme disease

Neurology — Mon, 15 Mar 2010 20:00:56 +0100

(Source: Neurology)

Brain scans now catch chemicals too

New Scientist - The Human Brain — Tue, 02 Mar 2010 17:09:00 +0100

A way to visualise chemicals washing through the brain could vastly extend the power of fMRI, a workhorse of neuroscience (Source: New Scientist - The Human Brain)

Experimental multiple sclerosis vascular shunting procedure halted at Stanford

Annals of Neurology — Tue, 23 Feb 2010 00:00:00 +0100

No abstract. (Source: Annals of Neurology)

Long-Term Evolution of Chronic Daily Headache With Medication Overuse in the General Population

Headache: The Journal of Head and Face Pain — Wed, 03 Mar 2010 00:00:00 +0100

Conclusions.[mdash] After 4 years, almost 60% of subjects did not fulfill CDHwMO criteria and their QoL was also improved. This justifies public health interventions that should include recommendations on a judicious use of symptomatic medications together with an early use of preventatives. (Headache 2010;[bull][bull]:[bull][bull]-[bull][bull]) (Source: Headache: The Journal of Head and Face Pain)

Neuroscientist Steers Research Into Neurological Disorders

Parkinson's Disease News From Medical News Today — Wed, 03 Mar 2010 08:00:00 +0100

Scientists at the Queensland Brain Institute have uncovered a vital clue into how the brain is wired, which could eventually steer research into nervous system disorders such as Parkinson's disease and cognitive disorders including autism. It's long been known that growing nerve fibres, also known as axons, must make connections in the brain for it to function properly... (Source: Parkinson's Disease News From Medical News Today)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

There May Be More vCJD Risks than Expected (CME/CE)

MedPage Today Neurology — Thu, 17 Dec 2009 22:30:00 +0100

Some people thought to be resistant to variant Creutzfeldt-Jakob disease (vCJD) on a genetic basis may in fact be vulnerable to the fatal syndrome, researchers said. (Source: MedPage Today Neurology)

West Nile Virus Therapies Reach Clinical Trials: Encephalitis incidence has steadily risen.

Clinical Neurology News — Mon, 31 Aug 2009 23:00:00 +0100

VAIL, COLO. — An intensive drug development effort targeting severe West Nile virus infections may be approaching a payoff. Options in the developmental pipeline include a number of monoclonal antibodies directed as passive immunotherapy against West Nile virus (WNV) proteins, as well as a promising Israeli human intravenous immunoglobulin (IVIG) product containing high titers of viral antibodies. In addition, a whole series of vaccines are in various stages of clinical trials, according to Dr. Kenneth L. Tyler, professor of neurology, medicine, and microbiology at the University of Colorado, Denver. (Source: Clinical Neurology News)

Copaxone(R) 15-Year Study In Multiple Sclerosis Patients Demonstrates Robust Long-Term Efficacy And Safety

Multiple Sclerosis News From Medical News Today — Sun, 28 Feb 2010 08:00:00 +0100

Teva Pharmaceutical Industries Ltd. (NASDAQ: TEVA) announced the publication of data from the 15-year clinical study with Copaxone® (glatiramer acetate injection), which is the longest prospective and continuous evaluation ever conducted in relapsing-remitting multiple sclerosis (RRMS) patients. The data were published in the February issue of the journal Multiple Sclerosis... (Source: Multiple Sclerosis News From Medical News Today)

A Stroke Study of an Urban Area of Iran: Risk Factors, Length of Stay, Case Fatality, and Discharge Destination

Journal of Stroke and Cerebrovascular Diseases — Sat, 27 Feb 2010 14:45:55 +0100

Conclusion: Hypertension and diabetes mellitus are more frequent here than average global findings. One-month case fatality was higher than in European countries but less than in developing countries. The most interesting difference comparing developed countries is the destination, which should be addressed. We strongly recommend establishing a stroke registry, establishing primary prevention, and promoting rehabilitation facilities in Iran. (Source: Journal of Stroke and Cerebrovascular Diseases)

Check out PPMD’s March newsletter, including new marathons for Spring and the latest update on the ataluren trials.www.parentprojectmd.org

Parent Project Muscular Dystrophy — Tue, 09 Mar 2010 00:00:00 +0100

Update on ataluren TrialsIn response to the press release that went out on March 3, 2010 from PTC Therapeutics regarding the ataluren trials, an open conference call was held on March 5 for parents to have their questions answered by PTC. Click here to read notes compiled from this important open conference call. Six Duchenne Funding Organizations Meet in Washington, D.C. The founding members of the Duchenne Research Collaborative Interational (DRCI), which is composed of Association Française contre les Myopathies (AFM), the Muscular Dystrophy Association (MDA), Parent Project Muscular Dystrophy (PPMD) and United Parent Project Muscular Dystrophy (UPPMD), met in Washington D.C. on February 20 along with fellow funding organizations Cure Duchenne and the Foundation to Eradicate Duchenne...

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Epstein-Barr Virus May Be Associated With Multiple Sclerosis

Multiple Sclerosis News From Medical News Today — Thu, 13 Apr 2006 09:00:00 +0100

Young adults with high levels of antibodies against the Epstein-Barr virus, the virus that most often causes mononucleosis, may be more likely to develop multiple sclerosis 15 to 20 years later, according to a study posted online today that will appear in the June 2006 print issue of Archives of Neurology, one of the JAMA/Archives journals. [click link for full article] (Source: Multiple Sclerosis News From Medical News Today)

Panel: vCJD Poses Small Risk in Plasma Product

Clinical Neurology News — Tue, 30 Jun 2009 23:00:00 +0100

GAITHERSBURG, MD. — A Food and Drug advisory panel agreed that a probable case of pre-clinical variant Creutzfeldt-Jakob disease attributed to a plasma product in the United Kingdom indicated that the transmissibility of the disease via a plasma-derived factor VIII product was no longer theoretical. (Source: Clinical Neurology News)

When we talk about Duchenne, we tend to focus on our sons. But there is a journey that women go on as mothers, daughters, sisters and as carriers. Read PPMD President Pat Furlong’s latest blog, about how Duchenne affects women, not just emotionally but physically.patfurlongsblog.blogspot.com

Parent Project Muscular Dystrophy — Fri, 05 Feb 2010 00:00:00 +0100

It was a long time ago that I sat in the exam room and received the diagnosis. My boys had Duchenne. The diagnosis was followed by a series of questions about my family history, the doctor assuming that somewhere along the line, there was another boy long ago. In my case, there was no history. None. I asked every living member of my mother’s family what they knew, if there was someone who had an unnamed ‘problem’, someone who was weak, or a child who died young from an unnamed illness. One of my cousins talked about my "crazy Uncle Harry” who fell off the roof, but it hardly fit the picture I was looking for. I had a brother Jack, who died young, at the age of 42. A heart attack after jogging. He was my closest friend and I wondered if he might have had a mild form of Duchenne – ...

Sleep disturbances in asymptomatic BRCA1/2 mutation carriers: women at high risk for breast–ovarian cancer

Journal of Sleep Research — Mon, 08 Mar 2010 00:00:00 +0100

In conclusion, asymptomatic BRCA1/2 carriers experience poor sleep quality compared to non-carriers and controls. Our study design is unique in that it offers insight regarding the nature of being an asymptomatic carrier, and affords the opportunity to examine factors that may contribute to the development of insomnia in women at risk for breast[ndash]ovarian cancer. (Source: Journal of Sleep Research)