MedWorm: Neurology

Bp decline during 24 hours after stroke predicts outcomes

MedWire News - Stroke — Sat, 17 May 2008 15:40:58 +0100

Stroke patients' outcomes at 3 months worsen the further their blood pressure declines in the 24 hours after their attack, suggest findings from an analysis of NINDS tissue plasminogen activator stroke studies data. (Source: MedWire News - Stroke)

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Improved cerebral vasoreactivity following percutaneous transluminal angioplasty with stenting of high-grade internal carotid artery stenosis

Cerebrovascular Diseases — Sat, 17 May 2008 14:39:59 +0100

Cerebrovasc Dis 2008;25:555-560 (DOI:10.1159/000132201) (Source: Cerebrovascular Diseases)

High satisfaction with an individualised stroke care programme after hospitalisation of patients with a tia or minor stroke: a pilot study

Cerebrovascular Diseases — Sat, 17 May 2008 14:39:59 +0100

Cerebrovasc Dis 2008;25:566-571 (DOI:10.1159/000132203) (Source: Cerebrovascular Diseases)

Stroke incidence in women under 60 years of age related to alcohol intake and smoking habit

Cerebrovascular Diseases — Sat, 17 May 2008 14:39:59 +0100

Cerebrovasc Dis 2008;25:517-525 (DOI:10.1159/000131669) (Source: Cerebrovascular Diseases)

Safety and efficacy of mri-based thrombolysis in unclear-onset stroke

Cerebrovascular Diseases — Sat, 17 May 2008 14:39:59 +0100

Cerebrovasc Dis 2008;25:572-579 (DOI:10.1159/000132204) (Source: Cerebrovascular Diseases)

Transient hyperperfusion after superficial temporal artery/middle cerebral artery bypass surgery as a possible cause of postoperative transient neurological deterioration

Cerebrovascular Diseases — Sat, 17 May 2008 14:39:59 +0100

Cerebrovasc Dis 2008;25:580-586 (DOI:10.1159/000132205) (Source: Cerebrovascular Diseases)

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Executive functions and cognitive subprocesses in patients with obstructive sleep apnoea

Journal of Sleep Research — Fri, 16 May 2008 18:34:11 +0100

Journal of Sleep Research, Volume 0, Issue 0, Page ???, OnlineEarly Articles. SummaryIn recent years, special interest has been focused on impairments of executive functions in patients with obstructive sleep apnoea syndrome (OSAS). However, the majority of studies have not clearly separated deficits in executive functions from ... (Source: Journal of Sleep Research)

Anisotropy in the representation of direction preferences in cat area 18

European Journal of Neuroscience — Fri, 16 May 2008 18:17:18 +0100

European Journal of Neuroscience, Volume 0, Issue 0, Page ???, December 2004. AbstractHigher visual cortical areas are involved in the perception of complex stimuli, such as the optic flow created by self-motion. On the other hand, area 18 is thought to extract primitive visual features, feeding higher cortical areas for further ... (Source: European Journal of Neuroscience)

Egr-1 is regulated by n-methyl-d-aspartate-receptor stimulation and associated with patient survival in human high grade astrocytomas

Brain Pathology — Fri, 16 May 2008 18:10:19 +0100

Brain Pathology, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Abstract Early growth response-1 (EGR-1) is considered a central regulator in tumor cell proliferation, migration and angiogenesis and a promising candidate for gene therapy in human astrocytomas. However, conflicting data have been reported suggesting ... (Source: Brain Pathology)

Multiple alpha-synuclein gene polymorphisms are associated with parkinson’s disease in a norwegian population

Acta Neurologica Scandinavica — Fri, 16 May 2008 18:04:49 +0100

Acta Neurologica Scandinavica, Volume 0, Issue 0, Page ???, December 2003. Myhre R, Toft M, Kachergus J, Hulihan MM, Aasly JO, Klungland H, Farrer MJ. Multiple alpha-synuclein gene polymorphisms are associated with Parkinson’s disease in a Norwegian population.Acta Neurol Scand: DOI: 10.1111/j.1600-0404.2008.01019.x© 2008 NTNU ... (Source: Acta Neurologica Scandinavica)

Alzheimer's and parkinson's diseases: progress and new perspectives. proceedings of the 8th international conference ad/pd, salzburg, austria, march 14-18, 2007.

Neuro-Degenerative Diseases — Fri, 16 May 2008 16:52:01 +0100

Alzheimer's and Parkinson's Diseases: Progress and New Perspectives. Proceedings of the 8th International Conference AD/PD, Salzburg, Austria, March 14-18, 2007.

Neurodegener Dis. 2008;5(3-4):109-266

Authors:

PMID: 18481370 [PubMed - indexed for MEDLINE]

(Source: Neuro-Degenerative Diseases)

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Beta blockers raise stroke risk in noncardiac surgery patients

MedWire News - Stroke — Fri, 16 May 2008 16:28:03 +0100

Giving beta blockers to patients undergoing noncardiac surgery reduces their risk for myocardial infarction but increases their risk for stroke and death, compared with placebo, results of POISE show. (Source: MedWire News - Stroke)

Profess: combination therapy falls short of noninferiority vs clopidogrel

Medscape Neurology & Neurosurgery Headlines — Fri, 16 May 2008 16:04:25 +0100

Results of a secondary stroke prevention trial show that the combination of aspirin and extended-release dipyridamole do not meet prespecified noninferiority criteria vs clopidogrel. Medscape Medical News (Source: Medscape Neurology & Neurosurgery Headlines)

Repeated administration of a dopamine d1 receptor agonist reverses the increased proportions of striatal dopamine d1high and d2high receptors in methamphetamine-sensitized rats

European Journal of Neuroscience — Fri, 16 May 2008 09:07:28 +0100

European Journal of Neuroscience, Volume 0, Issue 0, Page ???, December 2004. AbstractRepeated administration of psychostimulants produces a behavioural sensitization. Amphetamine-sensitized animals are known to have a higher proportion of high-affinity states of dopamine D2 receptors (D2High receptors) in the striatum. We recently ... (Source: European Journal of Neuroscience)

Fine-tuning clot-busting treatment for bleeding in brain dramatically increases survival

Stroke / Neuroprotection News From Medical News Today — Fri, 16 May 2008 09:00:00 +0100

A multicenter study led by Johns Hopkins doctors has fine-tuned the dosage and timing for administering clot-busting tissue plasminogen activator (tPA) to patients with strokes caused by bleeding within the brain. The treatment, as reported this week at the European Stroke Conference in Nice, France, has been shown to dramatically decrease death and disability in patients with this typically lethal subset of stroke. (Source: Stroke / Neuroprotection News From Medical News Today)

23andme and the parkinson's institute announce initiative to advance parkinson's disease research

Parkinson's Disease News From Medical News Today — Fri, 16 May 2008 09:00:00 +0100

23andMe, a privately-held personal genetics company, and The Parkinson's Institute and Clinical Center ("Parkinson's Institute") announced a research initiative under which Parkinson's Institute patients, with financial support from The Michael J. Fox Foundation, will enroll in the 23andMe Personal Genome Service™ to support the development of advanced methods for clinical and epidemiologic research for Parkinson's disease. (Source: Parkinson's Disease News From Medical News Today)

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Age 60 or older? get shingles vaccine

MedicineNet Migraine General — Fri, 16 May 2008 07:00:00 +0100

Title: Age 60 or Older? Get Shingles VaccineCategory: Health NewsCreated: 5/16/2008Last Editorial Review: 5/16/2008 (Source: MedicineNet Migraine General)

A comparison of parametric models for the investigation of the shape of cognitive change in the older population.

BMC Neurology — Fri, 16 May 2008 04:00:00 +0100

Background: Cognitive decline is a major threat to well being in later life. Change scores and regression based models have often been used for its investigation. Most methods used to describe cognitive decline assume individuals lose their cognitive abilities at a constant rate with time. The investigation of the parametric curve that best describes the process has been prevented by restrictions imposed by study design limitations and methodological considerations. We propose a comparison of parametric shapes that could be considered to describe the process of cognitive decline in late life. Attrition plays a key role in the generation of missing observations in longitudinal studies of older persons. As ignoring missing observations will produce biased results and previous studies point to the important effect of the last observed cognitive score on the probability of dropout, we propose modelling both mechanisms jointly to account for these two considerations in the model likelihood. Methods: Data from four interview waves of a population based longitudinal study of the older population, the Cambridge City over 75 Cohort Study were used. Within a selection model process, latent growth models combined with a logistic regression model for the missing data mechanism were fitted. To illustrate advantages of the model proposed, a sensitivity analysis of the missing data assumptions was conducted. Results: Results showed that a quadratic curve describes cognitive decline best. Significant heterogeneity between individuals about mean curve parameters was identified. At all interviews, MMSE scores before dropout were significantly lower than those who remained in the study. Individuals with good functional ability were found to be less likely to dropout, as were women and younger persons in later stages of the study. Conclusions: The combination of a latent growth model with a model for the missing data has permitted to make use of all available data and quantify the effect of significant predictors of dropout on the dropout and observational processes. Cognitive decline over time in older persons is often modelled as a linear process, though we have presented other parametric curves that may be considered. (Source: BMC Neurology)

Leucine induces phosphorylation and activation of p70s6k in cortical neurons via the system l amino acid transporter

Journal of Neurochemistry — Thu, 15 May 2008 18:31:45 +0100

Journal of Neurochemistry, Volume 0, Issue 0, Page ???, October 2004. Abstractp70S6 kinase is a multipotent kinase that phosphorylates substrates in response to extracellular stimuli. This kinase activity inhibits apoptosis, regulates cell size and controls translation. In the CNS, p70S6K also participates in synaptic ... (Source: Journal of Neurochemistry)

Utility, economic rationalism and the circumscription of agency

Journal of Intellectual Disability Research — Thu, 15 May 2008 18:30:51 +0100

Journal of Intellectual Disability Research, Volume 0, Issue 0, Page ???, December 2004. Abstract Background Great strides have been achieved over the past few decades in service provision for people with intellectual disability (ID). However, there has also been a growth in the use of economic rationalism and a related rise in ... (Source: Journal of Intellectual Disability Research)

Post-stroke sexual functioning in first stroke patients

European Journal of Neurology — Thu, 15 May 2008 18:18:18 +0100

European Journal of Neurology, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Background and purpose: Although physical problems after stroke have been well studied, there is little information on one of the crucial aspects of the quality of life of those patients, namely sexual functioning and satisfaction. The aim of this study ... (Source: European Journal of Neurology)

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Stroke risk identifies patients vulnerable to cognitive decline

MedWire News - Stroke — Thu, 15 May 2008 11:13:55 +0100

An individual's stroke risk is directly related to their cognitive function, researchers report. (Source: MedWire News - Stroke)

Combating stroke - outfitting device with drugs to prevent future stroke

Stroke / Neuroprotection News From Medical News Today — Thu, 15 May 2008 11:00:00 +0100

Dr. Pierre Gobin is the inventor of the MERCI Retriever, a catheter corkscrew device that slips into the blood vessels of the brain to hook onto and then remove blood clots. But now, Dr. Gobin is working on another pioneering advancement: the combination of the MERCI device with a drug delivery system to protect the affected part of the brain as blockages are removed. (Source: Stroke / Neuroprotection News From Medical News Today)

Profess(r) results announced at xvii european stroke conference

Stroke / Neuroprotection News From Medical News Today — Thu, 15 May 2008 11:00:00 +0100

Results of the PRoFESS(R) (Prevention Regimen For Effectively avoiding Second Strokes) trial -- the world's largest clinical research study for secondary stroke prevention -- were presented at the XVII European Stroke Conference in Nice, France. In the study, recurrent stroke event rates for Aggrenox(R) and clopidogrel were similar (9.0% and 8.8%, respectively; HR 1.01, 95% CI 0.92-1.11). (Source: Stroke / Neuroprotection News From Medical News Today)

Neurobiological technologies, inc. presents dosing rationale for viprinex(tm) (ancrod) at the european stroke conference

Stroke / Neuroprotection News From Medical News Today — Thu, 15 May 2008 11:00:00 +0100

Neurobiological Technologies, Inc. (NTI(R)) (Nasdaq: NTII) reported for the first time at the European Stroke Conference detailed analyses supporting the dosing regimen in NTI's two ongoing Phase 3 studies of Viprinex(TM) (ancrod) for ischemic stroke. (Source: Stroke / Neuroprotection News From Medical News Today)

Hypoxic preconditioning up-regulates glucose transport activity and glucose transporter (glut1 and glut3) gene expression after acute anoxic exposure in the cultured rat hippocampal neurons and astrocytes.

Brain Research — Thu, 15 May 2008 10:01:09 +0100

Hypoxic preconditioning up-regulates glucose transport activity and glucose transporter (GLUT1 and GLUT3) gene expression after acute anoxic exposure in the cultured rat hippocampal neurons and astrocytes.

Brain Res. 2008 May 23;1211C:22-29

Authors: Yu S, Zhao T, Guo M, Fang H, Ma J, Ding A, Wang F, Chan P, Fan M

Hypoxic preconditioning has been shown to increase the hypoxic tolerance of brain neurons. However, the mechanism underlying the increased hypoxic tolerance has not been well elucidated. Since anaerobic glycolysis is the only pathway for a vertebrate cell to produce energy under anoxic conditions, which needs a large amount of glucose, we hypothesize that glucose transport, the rate-limiting step for glucose metabolism, plays a critical role in the hypoxic tolerance induced by hypoxic preconditioning. In this study, the effects of hypoxic preconditioning on glucose transport activity and the gene expression of two major forms of glucose transporters (GLUT1 and GLUT3) in the brain were investigated in cultured rat hippocampal neurons and astrocytes. The neuronal and astroglial cultures were preconditioned for 6 days by intermittently exposing the cells to sublethal hypoxic gas mixture (1% O(2)/10% CO(2)/89% N(2)) for 20 min each day. 24 h after the last hypoxic exposure, the cells were exposed to a lethal anoxic gas mixture (10% CO(2)/90% N(2)) for 6 h and the uptake rate of [(3)H] 2-deoxyglucose (2-DG) and the levels of GLUT1 and GLUT3 glucose transporter mRNAs in the cells were examined immediately after anoxic exposure. The neurons and astrocytes preconditioned with hypoxia showed higher 2-DG uptake rates than the non-preconditioned cells. Compatible with the change in 2-DG uptake, hypoxic preconditioning also increased GLUT1 mRNA levels in the astrocytes and GLUT1 and GLUT3 mRNA levels in the neurons. The neurons preconditioned by hypoxia displayed increased anoxic tolerance. However, when glucose uptake in the neurons was blocked by cytochalasin B, the anoxic tolerance was almost abolished. These results suggest that glucose transport is critical to neuronal survival during anoxic exposure and the increased glucose transport activity is probably one of the important mechanisms for the enhanced hypoxic tolerance induced by hypoxic preconditioning.

PMID: 18474279 [PubMed - as supplied by publisher]

(Source: Brain Research)

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Study highlights need for early learning intervention in some children with ms

Multiple Sclerosis News From Medical News Today — Thu, 15 May 2008 10:00:00 +0100

Italian researchers compared cognitive function between 63 children with MS and 57 controls without MS, and found significant impairment in about one-third of the children with MS. The study results highlight the need for early interventions - such as accommodations that can be made in school - to address cognitive function in children with MS. Interventions of these types are among the comprehensive services offered at the National MS Society's network of Pediatric MS Centers of Excellence. (Source: Multiple Sclerosis News From Medical News Today)

Pharmacists play important part in stroke services

Stroke / Neuroprotection News From Medical News Today — Thu, 15 May 2008 10:00:00 +0100

The English Pharmacy Board of the Royal Pharmaceutical Society of Great Britain welcomes the government's emphasis on stroke treatment, as outlined in the recent announcement by the Department of Health to boost funding for stroke services. The number of patients receiving anticoagulation therapy has increased over the last years. (Source: Stroke / Neuroprotection News From Medical News Today)

Developmental and comparative aspects of posterior medial thalamocortical innervation of the barrel cortex in mice and rats

The Journal of Comparative Neurology — Thu, 15 May 2008 09:49:22 +0100

The thalamocortical projection to the rodent barrel cortex consists of inputs from the ventral posterior medial (VPM) and posterior medial (POm) nuclei that terminate in largely non-overlapping territories in and outside of layer IV. This projection in both rats and mice has been used extensively to study development and plasticity of highly organized synaptic circuits. Whereas the VPM pathway has been well characterized in both rats and mice, organization of the POm pathway has only been described in rats, and no studies have focused exclusively on the development of the POm projection. Here, using transport of Phaseolus vulgaris leucoagglutinin (PHA-L) or carbocyanine dyes, we characterize the POm thalamocortical innervation of adult mouse barrel cortex and describe its early postnatal development in both mice and rats. In adult mice, POm inputs form a dense plexus in layer Va that extends uniformly underneath layer IV barrels and septa. Innervation of layer IV is very sparse; a clear septal innervation pattern is evident only at the layer IV/Va border. This pattern differs subtly from that described previously in rats. Developmentally, in both species, POm axons are present in barrel cortex at birth. In mice, they occupy layer IV as it differentiates, whereas in rats, POm axons do not enter layer IV until 1-2 days after its emergence from the cortical plate. In both species, arbors undergo progressive and directed growth. However, no layer IV septal innervation pattern emerges until several days after the cytoarchitectonic appearance of barrels and well after the emergence of whisker-related clusters of VPM thalamocortical axons. The mature pattern resolves earlier in rats than in mice. Taken together, these data reveal anatomical differences between mice and rats in the development and organization of POm inputs to barrel cortex, with implications for species differences in the nature and plasticity of lemniscal and paralemniscal information processing. J. Comp. Neurol. 509:239-258, 2008. © 2008 Wiley-Liss, Inc. (Source: The Journal of Comparative Neurology)

Tranilast ameliorates experimental mesangial proliferative glomerulonephritis

Nephron Experimental Nephrology — Thu, 15 May 2008 09:48:05 +0100

Nephron Exp Nephrol 2008;109:e1 (DOI:10.1159/000131752) (Source: Nephron Experimental Nephrology)

Dexamethasone's prosurvival benefits in podocytes require extracellular signal-regulated kinase phosphorylation

Nephron Experimental Nephrology — Thu, 15 May 2008 09:48:05 +0100

Nephron Exp Nephrol 2008;109:e8 (DOI:10.1159/000131892) (Source: Nephron Experimental Nephrology)

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Levodopa-induced dyskinesias in parkinson's disease: etiology, impact on quality of life, and treatments

European Neurology — Thu, 15 May 2008 09:47:53 +0100

Eur Neurol 2008;60:57-66 (DOI:10.1159/000131893) (Source: European Neurology)

Pure eye muscle involvement in endocrine orbitopathy

European Neurology — Thu, 15 May 2008 09:47:53 +0100

Eur Neurol 2008;60:67-72 (DOI:10.1159/000131894) (Source: European Neurology)

Clock-drawing test performance in the normal elderly and its dependence on age and education

European Neurology — Thu, 15 May 2008 09:47:53 +0100

Eur Neurol 2008;60:73-78 (DOI:10.1159/000131895) (Source: European Neurology)

Mri-based score for acute basilar artery thrombosis

Cerebrovascular Diseases — Thu, 15 May 2008 09:47:46 +0100

Cerebrovasc Dis 2008;25:511-516 (DOI:10.1159/000131668) (Source: Cerebrovascular Diseases)

Association between metabolic syndrome and risk of stroke: a meta-analysis of cohort studies

Cerebrovascular Diseases — Thu, 15 May 2008 09:47:46 +0100

Cerebrovasc Dis 2008;25:539-547 (DOI:10.1159/000131672) (Source: Cerebrovascular Diseases)

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The impact of stroke on unpaid caregivers: results from the auckland regional community stroke study, 2002--2003

Cerebrovascular Diseases — Thu, 15 May 2008 09:47:46 +0100

Cerebrovasc Dis 2008;25:548-554 (DOI:10.1159/000131673) (Source: Cerebrovascular Diseases)

Long-term stroke prognosis in relation to medical prevention and lifestyle factors

Cerebrovascular Diseases — Thu, 15 May 2008 09:47:46 +0100

Cerebrovasc Dis 2008;25:526-532 (DOI:10.1159/000131670) (Source: Cerebrovascular Diseases)

Clinical severity predicts time to hospital admission in patients with spontaneous intracerebral hemorrhage

Cerebrovascular Diseases — Thu, 15 May 2008 09:47:46 +0100

Cerebrovasc Dis 2008;25:533-538 (DOI:10.1159/000131671) (Source: Cerebrovascular Diseases)

Myelin-induced microglial neurotoxicity can be controlled by microglial metabotropic glutamate receptors

Journal of Neurochemistry — Thu, 15 May 2008 09:46:40 +0100

Journal of Neurochemistry, Volume 0, Issue 0, Page ???, October 2004. AbstractMicroglia are present in an activated state in multiple sclerosis lesions. Incubation of primary cultured rat microglia with rat-brain derived myelin (0.1–1 μg/mL) for 24 h induced microglial activation; cells displayed enhanced ED1 staining, ... (Source: Journal of Neurochemistry)

Cycloserine-induced encephalopathy: evidence on brain mri

European Journal of Neurology — Thu, 15 May 2008 09:42:04 +0100

European Journal of Neurology, Volume 0, Issue 0, Page ???, OnlineEarly Articles. (Source: European Journal of Neurology)

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Hexosaminidase a deficiency as a differential of amyotrophic lateral sclerosis

European Journal of Neurology — Thu, 15 May 2008 09:42:04 +0100

European Journal of Neurology, Volume 0, Issue 0, Page ???, OnlineEarly Articles. (Source: European Journal of Neurology)

Frontotemporal dementia linked to chromosome 3 (ftd-3) – current concepts and the detection of a previously unknown branch of the danish ftd-3 family

European Journal of Neurology — Thu, 15 May 2008 09:42:04 +0100

European Journal of Neurology, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Background: Among patients with onset of dementia below the age of 65 years, frontotemporal dementia (FTD) is the second most prevalent cause, secondary only to Alzheimer’s disease. Recent advances in understanding the heterogeneous genetic background for ... (Source: European Journal of Neurology)

Cardiovagal modulation upon postural change is altered in huntington’s disease

European Journal of Neurology — Thu, 15 May 2008 09:42:03 +0100

European Journal of Neurology, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Background: Cardiac autonomic nervous system (ANS) dysfunction in Huntington’s disease (HD) might affect both the sympathetic and parasympathetic branch of the ANS. Results and Conclusions: The pattern of linear heart rate variability we found in mid ... (Source: European Journal of Neurology)

Monitoring of cbfv and time characteristics of oxygen-induced acute cns toxicity in humans

European Journal of Neurology — Thu, 15 May 2008 09:42:03 +0100

European Journal of Neurology, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Background: Hyperbaric oxygen can cause central nervous system (CNS) toxicity with seizures. We tested the hypothesis that CNS toxicity could be predictable by cerebral blood flow velocity (CBFV) monitoring.Method: We monitored 369 mandatory oxygen ... (Source: European Journal of Neurology)

The ipsilateral cortico-spinal tract is activated after hemiparetic stroke

European Journal of Neurology — Thu, 15 May 2008 09:42:02 +0100

European Journal of Neurology, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Background and purpose: The presence of a projection from the primary motor cortex to the ipsilateral muscles has been established in human, but whether this pathway contributes to functional recovery after stroke is unclear. We investigated whether the ... (Source: European Journal of Neurology)

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Pedunculopontine nucleus stimulation influences rem sleep in parkinson’s disease

European Journal of Neurology — Thu, 15 May 2008 09:19:36 +0100

European Journal of Neurology, Volume 0, Issue 0, Page ???, OnlineEarly Articles. (Source: European Journal of Neurology)

Drd3 ser9gly variant is not associated with essential tremor in a series of italian patients

European Journal of Neurology — Thu, 15 May 2008 09:19:36 +0100

European Journal of Neurology, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Background: Essential tremor (ET) is the most common movement disorder worldwide. Three susceptibility loci on chromosomes 3q13, 2p24.1, and 6p23 have been reported, but no causative genes were found. The Ser9Gly variant of dopamine D3 receptor (DRD3) ... (Source: European Journal of Neurology)

Do tias require investigation by thin-slice high-resolution diffusion mri with a 3t mr unit?

European Journal of Neurology — Thu, 15 May 2008 09:19:36 +0100

European Journal of Neurology, Volume 0, Issue 0, Page ???, OnlineEarly Articles. (Source: European Journal of Neurology)

The prevalence of the g2019s and r1441c/g/h mutations in lrrk2 in german patients with parkinson’s disease

European Journal of Neurology — Thu, 15 May 2008 09:19:35 +0100

European Journal of Neurology, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Background and purpose: The prevalence of the heterozygous G2019S and R1441C/G/H mutations in LRRK2 in patients with Parkinson’s disease (PD) has shown a great variability depending on the sample population. Here we investigated the prevalence of these ... (Source: European Journal of Neurology)