MedWorm: Neurosurgery

Formation of Two Consecutive Intrathecal Catheter Tip Granulomas within Nine Months

Zentralblatt fur Neurochirurgie - Central European Neurosurgery — Thu, 19 Nov 2009 03:03:45 +0100

Zentralbl NeurochirDOI: 10.1055/s-0029-1202359AbstractThe formation of catheter tip granulomas is an increasingly observed serious complication of intrathecally administered medication. This complication, which is frequently associated with neurological disturbances, has previously been attributed to high dosages and high concentrations of intrathecal morphine. Much less commonly, intrathecal hydromorphone and intrathecal baclofen have also been associated with intrathecal granuloma formation. In the current case, we report a patient who developed her first catheter tip granuloma after 20 months of intrathecal morphine. After surgical granuloma removal and installation of a new catheter, the patient received intrathecal ziconitide for an interim period of six months. Because of a progressi...

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Endoscopic Anatomy for Transnasal Transsphenoidal Pituitary Surgery in the Presence of a Persistent Trigeminal Artery

Zentralblatt fur Neurochirurgie - Central European Neurosurgery — Wed, 18 Nov 2009 16:34:20 +0100

Zentralbl Neurochir 2009; 70: 207-210DOI: 10.1055/s-0028-1093354Abstract Endoscopic procedures are becoming increasingly important for transnasal transsphenoidal approaches to the skull base and particularly for pituitary surgery. A persistent trigeminal artery (PTA) is rare. Its presence, if it goes unnoticed or if the surgeon is not aware of such a variant, may endanger the success of surgery.[...]© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Abstract | Full text (Source: Zentralblatt fur Neurochirurgie - Central European Neurosurgery)

The neurology of olfaction

Journal of Neurology, Neurosurgery & Psychiatry — Mon, 16 Nov 2009 18:01:34 +0100

(Source: Journal of Neurology, Neurosurgery & Psychiatry)

The old age psychiatry handbook. A practical guide

Journal of Neurology, Neurosurgery & Psychiatry — Mon, 16 Nov 2009 18:01:34 +0100

(Source: Journal of Neurology, Neurosurgery & Psychiatry)

Epilepsy in women

Journal of Neurology, Neurosurgery & Psychiatry — Mon, 16 Nov 2009 18:01:34 +0100

(Source: Journal of Neurology, Neurosurgery & Psychiatry)

Behavioural abnormalities associated with rapid deterioration of language functions in semantic dementia respond to sertraline

Journal of Neurology, Neurosurgery & Psychiatry — Mon, 16 Nov 2009 18:01:33 +0100

(Source: Journal of Neurology, Neurosurgery & Psychiatry)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Posterior circulation strokes without systemic involvement as the presenting feature of Fabry disease

Journal of Neurology, Neurosurgery & Psychiatry — Mon, 16 Nov 2009 18:01:33 +0100

(Source: Journal of Neurology, Neurosurgery & Psychiatry)

Characteristics of abnormal eating behaviours in frontotemporal lobar degeneration: a cross-cultural survey

Journal of Neurology, Neurosurgery & Psychiatry — Mon, 16 Nov 2009 18:01:33 +0100

(Source: Journal of Neurology, Neurosurgery & Psychiatry)

Immunotherapy: responsive autoimmune encephalopathy associated with bullous pemphigoid

Journal of Neurology, Neurosurgery & Psychiatry — Mon, 16 Nov 2009 18:01:33 +0100

(Source: Journal of Neurology, Neurosurgery & Psychiatry)

Genetic Creutzfeldt-Jakob disease mimicking variant Creutzfeldt-Jakob disease

Journal of Neurology, Neurosurgery & Psychiatry — Mon, 16 Nov 2009 18:01:33 +0100

(Source: Journal of Neurology, Neurosurgery & Psychiatry)

Johann Cristian Reil on the 200th anniversary of the first description of the insula (1809)

Journal of Neurology, Neurosurgery & Psychiatry — Mon, 16 Nov 2009 18:01:33 +0100

(Source: Journal of Neurology, Neurosurgery & Psychiatry)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Clinical and mutational spectrum of limb-girdle muscular dystrophy type 2I in 11 French patients

Journal of Neurology, Neurosurgery & Psychiatry — Mon, 16 Nov 2009 18:01:33 +0100

Conclusions: This study reveals inter- and intrafamilial phenotypic variability in LGMD2I, with a preponderance of myocardiopathy and restrictive respiratory insufficiency. It also demonstrates central nervous involvement, probably associated with changes in -dystroglycan expression in the brain. (Source: Journal of Neurology, Neurosurgery & Psychiatry)

Frequency and phenotype of SPG11 and SPG15 in complicated hereditary spastic paraplegia

Journal of Neurology, Neurosurgery & Psychiatry — Mon, 16 Nov 2009 18:01:33 +0100

Conclusions: TCC seems to be the best phenotypic predictor for SPG11 as well as SPG15. No clinical features could discriminate between SPG11 and SPG15. Therefore, priority of genetic testing should be driven by mutation frequency that appears to be substantially higher in SPG11 than in SPG15. (Source: Journal of Neurology, Neurosurgery & Psychiatry)

Long-term mortality and vascular event risk after aneurysmal subarachnoid haemorrhage

Journal of Neurology, Neurosurgery & Psychiatry — Mon, 16 Nov 2009 18:01:33 +0100

Conclusion: SAH patients who recover to a functional independent state have an excess mortality compared with the general population. The risk of vascular events after SAH is lower than after minor stroke, but higher than the population risks reported in the literature. (Source: Journal of Neurology, Neurosurgery & Psychiatry)

Bilateral periventricular nodular heterotopia in France: frequency of mutations in FLNA, phenotypic heterogeneity and spectrum of mutations

Journal of Neurology, Neurosurgery & Psychiatry — Mon, 16 Nov 2009 18:01:33 +0100

Bilateral periventricular nodular heterotopia (BPNH) is the most common form of periventricular heterotopia. Mutations in FLNA, encoding filamin A, are responsible for the X linked dominant form of BPNH (FLNA-BPNH). Recently, atypical phenotypes including BPNH with Ehlers–Danlos syndrome (BPNH-EDS) have been recognised. A total of 44 FLNA mutations have so far been reported in this phenotype. Most of these mutations lead to a truncated protein, but few missense mutations have also been described. Here, the results of a mutation screening conducted in a series of 32 BPNH patients with the identification of 12 novel point mutations in 15 patients are reported. Nine mutations were truncating, while three were missense. Three additional patients with BPNH-EDS and a mutation in FLNA are d...

Tongue pseudohypertrophy in idiopathic hypoglossal nerve palsy

Journal of Neurology, Neurosurgery & Psychiatry — Mon, 16 Nov 2009 18:01:33 +0100

(Source: Journal of Neurology, Neurosurgery & Psychiatry)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Impact of posterior communicating artery on basilar artery steno-occlusive disease

Journal of Neurology, Neurosurgery & Psychiatry — Mon, 16 Nov 2009 18:01:33 +0100

Conclusions: Fetal-variant PcoA appears to act as a safeguard against ischaemic insult in acute stroke victims involving the brainstem with BA occlusive disease. This result can be explained by the fact that patients with fetal-variant PcoA have a smaller area of posterior circulation and a possibility of retrograde filling into the upper brainstem through the fetal-variant PcoA. (Source: Journal of Neurology, Neurosurgery & Psychiatry)

Inherited Creutzfeldt-Jakob disease in a Dutch patient with a novel five octapeptide repeat insertion and unusual cerebellar morphology

Journal of Neurology, Neurosurgery & Psychiatry — Mon, 16 Nov 2009 18:01:33 +0100

An atypical case of inherited Creutzfeldt–Jakob disease (CJD) is described in a 35-year-old Dutch woman, homozygous for methionine at codon 129 of the prion protein gene (PRNP). The clinical phenotype was characterised by slowly progressive cognitive decline and parkinsonism. Neuropathological findings consisted of scanty spongiosis and only faint to absent immunohistochemical staining for the abnormal prion protein, PrPSc, with patchy deposits in the cerebellar cortex. Purkinje cells were abnormally located in the molecular layer of the cerebellum. Western blot analysis showed the co-occurrence of PrPSc types 1 and 2 with an unusual distribution. Sequence analysis disclosed a novel 120 bp insertion in the octapeptide repeat region of the PRNP, encoding five additional R2 octapeptide...

Prospective surveillance of drain associated meningitis/ventriculitis in a neurosurgery and neurological intensive care unit

Journal of Neurology, Neurosurgery & Psychiatry — Mon, 16 Nov 2009 18:01:33 +0100

Conclusions: To the best of the authors' knowledge, this study represents the first to provide data on EVD as well as LD associated meningitis rates calculated per 1000 DD; a parameter that is well established for other invasive devices such as central venous and urinary tract catheters. However, further prospective studies are needed to investigate the possible risk factors for meningitis. (Source: Journal of Neurology, Neurosurgery & Psychiatry)

A reappraisal of the value of lateral spread response monitoring in the treatment of hemifacial spasm by microvascular decompression

Journal of Neurology, Neurosurgery & Psychiatry — Mon, 16 Nov 2009 18:01:33 +0100

Conclusions: Monitoring MVD by recording LSRs intraoperatively could be of value not only to indicate the resolution of the vasculonervous conflict at the end of surgery, but also to predict a successful clinical outcome in the long term after the surgical intervention. (Source: Journal of Neurology, Neurosurgery & Psychiatry)

The diagnostic value of provocative clinical tests in ulnar neuropathy at the elbow is marginal

Journal of Neurology, Neurosurgery & Psychiatry — Mon, 16 Nov 2009 18:01:33 +0100

Conclusion: The diagnostic value of provocative clinical tests in UNE is poor. (Source: Journal of Neurology, Neurosurgery & Psychiatry)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Validity of diagnostic criteria for chronic inflammatory demyelinating polyneuropathy: a multicentre European study

Journal of Neurology, Neurosurgery & Psychiatry — Mon, 16 Nov 2009 18:01:33 +0100

Conclusions: In our patient populations, the EFNS/PNS criteria were the most sensitive and allowed identification of a highly significantly greater number of patients than Koski et al’s criteria. The latter were comparable in specificity with the "definite/probable" EFNS/PNS electrodiagnostic subcategories. More extensive nerve-conduction studies improved diagnostic yield but resulted in loss of specificity. (Source: Journal of Neurology, Neurosurgery & Psychiatry)

Epidemiology and pathophysiology of falls in facioscapulohumeral disease

Journal of Neurology, Neurosurgery & Psychiatry — Mon, 16 Nov 2009 18:01:33 +0100

Conclusion: These findings demonstrate the high prevalence and clinical relevance of falls in FSHD. The relation between muscle weakness and instability among fallers is also highlighted. Because patients fell mainly at home, fall prevention strategies should focus on home adaptations. As mainly intrinsic causes underlie falls, the impact of adopting balance strategies or balance training should be explored in this patient group. (Source: Journal of Neurology, Neurosurgery & Psychiatry)

A case of stroke induced micrographia

Journal of Neurology, Neurosurgery & Psychiatry — Mon, 16 Nov 2009 18:01:33 +0100

(Source: Journal of Neurology, Neurosurgery & Psychiatry)

Assessment of spinal somatosensory systems with diffusion tensor imaging in syringomyelia

Journal of Neurology, Neurosurgery & Psychiatry — Mon, 16 Nov 2009 18:01:33 +0100

Conclusions: The data indicate that diffusion tensor imaging with 3D-fibre tracking is a new imaging method suitable for the objective and quantitative anatomical assessment of spinal somatosensory system dysfunction. (Source: Journal of Neurology, Neurosurgery & Psychiatry)

Proinflammatory cell stress in sporadic inclusion body myositis muscle: overexpression of {alpha}B-crystallin is associated with amyloid precursor protein and accumulation of {beta}-amyloid

Journal of Neurology, Neurosurgery & Psychiatry — Mon, 16 Nov 2009 18:01:33 +0100

Conclusion: Our results suggest that B-crystallin is associated with overexpression of APP in sIBM muscle and that upregulation of B-crystallin precedes accumulation of β-amyloid. The data help to better understand early pathological changes and underscore the fact that a network of cell stress, inflammation and degeneration is relevant to sIBM. (Source: Journal of Neurology, Neurosurgery & Psychiatry)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

New acute and chronic black holes in patients with multiple sclerosis randomised to interferon beta-1b or glatiramer acetate

Journal of Neurology, Neurosurgery & Psychiatry — Mon, 16 Nov 2009 18:01:33 +0100

Background: Hypointense lesions on T1 weighted MRI, referred to as black holes (BH), are a marker of demyelination/axonal loss in multiple sclerosis (MS). There is some evidence that glatiramer acetate (GA) may decrease the conversion of new brain lesions to BH. Methods: Monthly 3-Tesla brain MRI scans were used for up to 2 years to study the development and evolution of new BH in 75 patients with MS randomised to GA or Interferon β-1b (IFNβ1b) in the BECOME study. Findings: Of 1224 newly enhancing lesions (NEL) appearing at baseline through 24 months in 61 patients, 767 (62.7%) showed an acute BH (ABH). The majority of ABH were transient and of similar duration by treatment group. Of 571 ABH in which MRI follow-up scans were available for >=1 year, 103 (18.8%) were still vi...

MR spectroscopy indicates diffuse multiple sclerosis activity during remission

Journal of Neurology, Neurosurgery & Psychiatry — Mon, 16 Nov 2009 18:01:33 +0100

Conclusions: The absence of early tissue atrophy and apparent axonal dysfunction (NAA loss) in these RR MS patients suggests that both are preceded by diffuse glial proliferation (astrogliosis), as well as possible inflammation, demyelination and remyelination reflected by elevated mI, Cho and Cr, even during clinical remission and despite immunomodulatory treatment. (Source: Journal of Neurology, Neurosurgery & Psychiatry)

Double depressor palsy caused by bilateral paramedian thalamic infarcts

Journal of Neurology, Neurosurgery & Psychiatry — Mon, 16 Nov 2009 18:01:33 +0100

(Source: Journal of Neurology, Neurosurgery & Psychiatry)

Functional magnetic resonance imaging study on dysphagia after unilateral hemispheric stroke: a preliminary study

Journal of Neurology, Neurosurgery & Psychiatry — Mon, 16 Nov 2009 18:01:33 +0100

Conclusions: The results indicate that unilateral stroke of either cerebral hemisphere can produce dysphagia. Effective recovery is associated with cerebral activation related to cortical swallowing representation in the compensating or recruited areas of the intact hemisphere. Functional MRI is a useful method for exploring the spatial localisation of changes in neuronal activity during tasks that may be related to recovery. Therefore, the subsequent information gleaned from changes in neural plasticity could be useful for assessing the prognosis of dysphagic stroke. (Source: Journal of Neurology, Neurosurgery & Psychiatry)

Somatosensory temporal discrimination in patients with primary focal dystonia

Journal of Neurology, Neurosurgery & Psychiatry — Mon, 16 Nov 2009 18:01:33 +0100

Conclusions: These results provide definitive evidence that STDT abnormalities are a generalised feature of patients with primary focal dystonias and are a valid tool for screening subclinical sensory abnormalities. (Source: Journal of Neurology, Neurosurgery & Psychiatry)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Diagnosis and new treatments in genetic neuropathies

Journal of Neurology, Neurosurgery & Psychiatry — Mon, 16 Nov 2009 18:01:33 +0100

The genetic neuropathies are a clinically and genetically heterogeneous group of diseases of which the most common types are Charcot–Marie–Tooth disease (CMT), the hereditary sensory and autonomic neuropathies and the distal hereditary motor neuropathies. More than 30 causative genes have been described, making an accurate genetic diagnosis increasingly possible. Although no specific therapies are yet available, research into their pathogenesis has revolutionised our understanding of the peripheral nervous system and allowed the development of rational approaches to therapy. The first therapeutic trials in CMT are currently underway. This review will suggest an approach to the diagnosis of these disorders and provide an update on new therapies. (Source: Journal of Neurology, Ne...

Can mutations of prion protein shed light on its normal function?

Journal of Neurology, Neurosurgery & Psychiatry — Mon, 16 Nov 2009 18:01:33 +0100

(Source: Journal of Neurology, Neurosurgery & Psychiatry)

Drain associated meningitis and ventriculitis remains a pivotal problem in neurointensive care: to understand their causes we need better surveillance data

Journal of Neurology, Neurosurgery & Psychiatry — Mon, 16 Nov 2009 18:01:33 +0100

(Source: Journal of Neurology, Neurosurgery & Psychiatry)

Sporadic inclusion body myositis: evidence of a link between inflammation, cell stress and {beta}-amyloid deposition

Journal of Neurology, Neurosurgery & Psychiatry — Mon, 16 Nov 2009 18:01:32 +0100

(Source: Journal of Neurology, Neurosurgery & Psychiatry)

Long-term results of thalamic deep brain stimulation for essential tremor.

Journal of Neurosurgery — Fri, 13 Nov 2009 00:00:00 +0100

Conclusions Deep brain stimulation of the VIM is an efficient and safe treatment for ET. Tremor and handwriting improvements in long-term follow-up are stable. The patients' perception of their outcome is quite good. However, tolerance may develop in some patients requiring changes in stimulation parameters. PMID: 19911883 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Ventricular enlargement due to acute hypernatremia in a patient with a ventriculoperitoneal shunt.

Journal of Neurosurgery — Fri, 13 Nov 2009 00:00:00 +0100

Authors: Andres RH, Pendharkar AV, Kuhlen D, Mariani L Patients requiring CSF shunts frequently have comorbidities that can influence water and electrolyte balances. The authors report on a case involving a ventriculoperitoneal shunt in a patient who underwent intravenous hyperhydration and withdrawal of vasopressin substitution prior to scheduled high-dose chemotherapy regimen for a metastatic suprasellar germinoma. After acute neurological deterioration, the patient underwent CT scanning that demonstrated ventriculomegaly. A shunt tap revealed no flow and negative opening pressure. Due to suspicion of proximal shunt malfunction, the comatose patient underwent immediate surgical exploration of the ventricle catheter, which was found to be patent. However, acute severe hypernatremia wa...

Atypical teratoid/rhabdoid tumor of the pineal region in an adult.

Journal of Neurosurgery — Fri, 13 Nov 2009 00:00:00 +0100

Authors: Takei H, Adesina AM, Mehta V, Powell SZ, Langford LA An atypical teratoid/rhabdoid tumor (AT/RT) is a highly malignant embryonal tumor most often occurring in the posterior fossa in children younger than 3 years of age. Adult cases of AT/RT are very rare, and 27 cases with a diagnosis of either AT/RT or (malignant) rhabdoid tumor have been reported to date. The authors report an adult case of an AT/RT occurring in the pineal region with molecular cytogenetic and immunohistochemical confirmation. A 33-year-old woman presented with a 2-month history of headache and blurred vision progressing to diplopia, and was admitted emergently due to deteriorating mental status. An MR image showed a heterogeneously enhancing mass involving the posterior third ventricle and pineal region wit...

Hypomania with hypersexuality following bilateral anterior limb stimulation in obsessive-compulsive disorder.

Journal of Neurosurgery — Fri, 13 Nov 2009 00:00:00 +0100

Authors: Chang CH, Chen SY, Hsiao YL, Tsai ST, Tsai HC This 28-year-old Chinese man was referred for deep brain stimulation (DBS) evaluation for an 8-year history of refractory obsessive-compulsive disorder. After the patient had signed an informed consent, the authors implanted DBS leads. Hypomania with hypersexuality was noted on stimulation at Contact 2 and became aggravated with a higher voltage (>/=3 V) during chronic bilateral DBS. After the voltage was decreased to 1 V, the patient's hypomanic symptoms subsided and his libido returned to baseline. PMID: 19911886 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)

Nationwide study of decompressive surgery for malignant supratentorial infarction in the Czech Republic: utilization and outcome predictors.

Journal of Neurosurgery — Fri, 13 Nov 2009 00:00:00 +0100

Conclusions In 2006 decompressive surgery was underutilized and occurred late in the clinical course in the Czech Republic. Revision of national guidelines is necessary to incorporate the latest data and ensure that the patients who can benefit most receive treatment. PMID: 19911887 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)

Resection of malignant brain tumors in eloquent cortical areas: a new multimodal approach combining 5-aminolevulinic acid and intraoperative monitoring.

Journal of Neurosurgery — Fri, 13 Nov 2009 00:00:00 +0100

Conclusions The authors' first results show that tumor resections with 5-ALA in combination with intraoperative cortical stimulation have the advantages of both methods and, thus, provide additional safety for the neurosurgeon during resections of primary malignant brain tumors in eloquent areas. Nonetheless, more cases and additional studies are necessary to further prove the advantages of this multimodal strategy. PMID: 19911888 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Cerebrospinal fluid shunt insertion: techniques of peritoneal catheter placement separate from abdominal fascial and peritoneal incisions.

Journal of Neurosurgery — Fri, 13 Nov 2009 00:00:00 +0100

In this report, the authors describe a simple technique for passing the peritoneal catheter of a ventriculoperitoneal shunt through the abdominal wall on a pathway separate from the fascial opening. This technique minimizes the risk of abdominal wall-related complications and is especially important in high-risk patients such as those with obesity and/or diabetes and in children. PMID: 19911889 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)

Intracellular free magnesium of brain and cerebral phosphorus-containing metabolites after subarachnoid hemorrhage and hypermagnesemic treatment: a (31)P-magnetic resonance spectroscopy study.

Journal of Neurosurgery — Fri, 13 Nov 2009 00:00:00 +0100

Conclusions The MRS finding of elevated brain free intracellular magnesium after intravenous magnesium sulfate infusion is novel, and the changes in membrane metabolism provide insight into the metabolic effects of aneurysmal SAH and future pathophysiological studies. PMID: 19911890 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)

Burst stimulation of the auditory cortex: a new form of neurostimulation for noise-like tinnitus suppression.

Journal of Neurosurgery — Fri, 13 Nov 2009 00:00:00 +0100

Conclusions Burst stimulation is a new form of neurostimulation that might be helpful in treating symptoms that are intractable to conventional tonic stimulation. Further exploration of this new stimulation design is warranted. PMID: 19911891 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)

Age- and time-dependent effects on functional outcome and cortical activation pattern in patients with median nerve injury: a functional magnetic resonance imaging study.

Journal of Neurosurgery — Fri, 13 Nov 2009 00:00:00 +0100

Conclusions Following a median nerve injury (1-11 years after injury) there may be an initial increase in the volume of the cortical representation, which subsequently declines during the restoration phase. These dynamic changes may involve both median and ulnar nerve cortical representation, because both showed negative correlation with time after injury. These findings are in agreement with animal studies showing that cortical plasticity is an important mechanism for functional recovery after peripheral nerve injury and repair. PMID: 19911892 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)

Cellular transplantation for the nervous system: impact of time after preparation on cell viability and survival.

Journal of Neurosurgery — Fri, 13 Nov 2009 00:00:00 +0100

Conclusions The authors' results indicate that that there can be significant losses in viability between preparation and implantation and that more sophisticated methods of evaluation, such as the ability of cells to attach to a substrate and grow, may be required to detect decreases in viability. The time between preparation and implantation will be an important factor in clinical trial design. PMID: 19911893 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Continuous hypertension and tachycardia after resection of a hemangioblastoma behind the dorsal medulla oblongata: relationship to sympathetic overactivity at the neurogenic vasomotor center.

Journal of Neurosurgery — Fri, 13 Nov 2009 00:00:00 +0100

Authors: Ideguchi M, Kajiwara K, Yoshikawa K, Kato S, Ishihara H, Fujii M, Fujisawa H, Suzuki M A very rare case of continuous hypertension and tachycardia after excision of a cerebellar hemangioblastoma at the dorsal medulla oblongata is presented. This 21-year-old man was admitted to the authors' hospital with a headache and dizziness. Radiological examination revealed a tumor located behind the dorsal medulla oblongata and compressing it substantially. The tumor was completely resected, but after the surgery the patient experienced prolonged hypertension and tachycardia. Postoperative MR imaging showed a small injury at the dorsocaudal medulla that was located at the caudal site of the nucleus of the tractus solitarius (NTS). Because the NTS has been reported to play a central role ...

Effectiveness of an epidural blood patch for patients with intracranial hypotension syndrome and persistent spinal epidural fluid collection after treatment.

Journal of Neurosurgery — Fri, 13 Nov 2009 00:00:00 +0100

Conclusions An epidural blood patch is effective for sealing of CSF leaks, but the resolution of SIHS-related symptoms does not always imply complete eradication of the leakage. PMID: 19911895 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)

Erratum

Zentralblatt fur Neurochirurgie - Central European Neurosurgery — Thu, 12 Nov 2009 02:41:16 +0100

Zentralbl NeurochirDOI: 10.1055/s-0029-1243182© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | FREE: Full text (Source: Zentralblatt fur Neurochirurgie - Central European Neurosurgery)

Epidemiology, Prevention and Management of Ventriculoperitoneal Shunt Infections in Children

Pediatric Neurosurgery — Tue, 10 Nov 2009 23:00:00 +0100

Pediatr Neurosurg 2009;45:325-336 (DOI:10.1159/000257520) (Source: Pediatric Neurosurgery)

Aggressive Surgical Management of Patients with Chiari II Malformation and Brainstem Dysfunction

Pediatric Neurosurgery — Tue, 10 Nov 2009 23:00:00 +0100

Pediatr Neurosurg 2009;45:337-344 (DOI:10.1159/000257521) (Source: Pediatric Neurosurgery)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Is Postoperative CT Scanning Predictive of Subdural Electrode Placement Complications in Pediatric Epileptic Patients?

Pediatric Neurosurgery — Tue, 10 Nov 2009 23:00:00 +0100

Pediatr Neurosurg 2009;45:345-349 (DOI:10.1159/000257522) (Source: Pediatric Neurosurgery)

Characteristics of Osseous Septum of Split Cord Malformation in Patients Presenting with Scoliosis: A Retrospective Study of 48 Cases

Pediatric Neurosurgery — Tue, 10 Nov 2009 23:00:00 +0100

Pediatr Neurosurg 2009;45:350-353 (DOI:10.1159/000257523) (Source: Pediatric Neurosurgery)

Diagnosis and Treatment of Intracranial Immature Teratoma

Pediatric Neurosurgery — Tue, 10 Nov 2009 23:00:00 +0100

Pediatr Neurosurg 2009;45:354-360 (DOI:10.1159/000257524) (Source: Pediatric Neurosurgery)

Endoscopic Third Ventriculostomy: The Lebanese Experience

Pediatric Neurosurgery — Tue, 10 Nov 2009 23:00:00 +0100

Pediatr Neurosurg 2009;45:361-367 (DOI:10.1159/000257525) (Source: Pediatric Neurosurgery)

Congenital Tumors of the Central Nervous System: The MCH Experience

Pediatric Neurosurgery — Tue, 10 Nov 2009 23:00:00 +0100

Pediatr Neurosurg 2009;45:368-374 (DOI:10.1159/000257526) (Source: Pediatric Neurosurgery)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Trigeminal neurinomas with extracranial extension: analysis of 28 surgically treated cases.

Journal of Neurosurgery — Fri, 06 Nov 2009 00:00:00 +0100

Conclusions Extracranial extensions of trigeminal neurinomas have a well-defined meningeal covering. In most cases resection was performed via a minimally invasive cranial avenue (a "reverse skull base approach"). Radical resection was associated with an excellent long-term outcome. PMID: 19895193 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)

Image-guided anatomical and morphometric study of supraorbital and transorbital minicraniotomies to the sellar and perisellar regions: comparison with standard techniques.

Journal of Neurosurgery — Fri, 06 Nov 2009 00:00:00 +0100

Conclusions In refining the concept of working area as deep rather than superficial in the surgical field, the authors quantified the 6 triangles whose boundaries were relative to the target structures to be exposed in the approach. The authors' morphometric findings support the use of the supraorbital and transorbital approaches as a valid alternative to the pterional approach for the treatment of sellar and perisellar pathology. The transorbital approach combines the advantages of minimal invasiveness with those of cranial base techniques. PMID: 19895194 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)

A unifying hypothesis for a patient with superficial siderosis, low-pressure headache, intraspinal cyst, back pain, and prominent vascularity.

Journal of Neurosurgery — Fri, 06 Nov 2009 00:00:00 +0100

Authors: Kumar N, Miller GM, Piepgras DG, Mokri B A source of bleeding is often not evident during the evaluation of patients with superficial siderosis of the CNS despite extensive imaging. An intraspinal fluid-filled collection of variable dimensions is frequently observed on spine MR imaging in patients with idiopathic superficial siderosis. A similar finding has also been reported in patients with idiopathic intracranial hypotension. The authors report on a patient with superficial siderosis and a longitudinally extensive intraspinal fluid-filled collection secondary to a dural tear. The patient had a history of low-pressure headaches. His spine MR imaging and spine CT suggested the possibility of an underlying vascular malformation, but none was found on angiography. Repair of the...

Imaging of hypoxic lesions in patients with gliomas by using positron emission tomography with 1-(2-[(18)F] fluoro-1-[hydroxymethyl]ethoxy)methyl-2-nitroimidazole, a new (18)F-labeled 2-nitroimidazole analog.

Journal of Neurosurgery — Fri, 06 Nov 2009 00:00:00 +0100

Conclusions Imaging with FRP-170 PET can visualize hypoxic lesions in patients with glioma, as confirmed by histological examination. This new method can assess tumor hypoxia preoperatively and noninvasively. PMID: 19895196 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)

Gamma Knife thalamotomy for treatment of essential tremor: long-term results.

Journal of Neurosurgery — Fri, 06 Nov 2009 00:00:00 +0100

Conclusions A VIM thalamotomy with the Leksell GK offers a safe and effective alternative for surgical treatment of ET. It is particularly applicable to patients who are not ideal candidates for deep brain stimulation but can be offered to all patients who are considering surgical intervention for ET. PMID: 19895197 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

The sublime bridge: anatomy and implications in median nerve entrapment.

Journal of Neurosurgery — Fri, 06 Nov 2009 00:00:00 +0100

Conclusions Based on the authors' study, pronator syndrome is an incorrect term applied to compression of the median nerve at the sublime bridge. This potential site of median nerve compression is distinct and has characteristics that can clinically differentiate it from compression of the median nerve between the heads of the pronator teres. The authors hope that these data will be of use to the surgeon in the evaluation and treatment of patients with proximal median nerve entrapment. PMID: 19895198 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)

Vaccine therapy with dendritic cells transfected with Il13ra2 mRNA for glioma in mice.

Journal of Neurosurgery — Fri, 06 Nov 2009 00:00:00 +0100

Conclusions These results demonstrate the therapeutic potential of vaccination with dendritic cells transfected with Il13ra2 mRNA for the treatment of malignant glioma. PMID: 19895199 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)

Effect of subthalamic deep brain stimulation on postural abnormality in Parkinson disease.

Journal of Neurosurgery — Fri, 06 Nov 2009 00:00:00 +0100

Conclusions Postural abnormality in patients with PD could be ameliorated by STN DBS, and therefore surgery should be considered before irreversible spinal deformity develops. PMID: 19895200 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)

Adenosine A(2A) receptors in early ischemic vascular injury after subarachnoid hemorrhage.

Journal of Neurosurgery — Fri, 06 Nov 2009 00:00:00 +0100

Conclusions These results demonstrate that global inactivation of A(2A) receptors decreases the intensity of the early vascular response to SAH. Early inhibition of A(2A) receptors after SAH might reduce cerebral injury. PMID: 19895201 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)

Attenuation of astrogliosis and modulation of endothelial growth factor receptor in lipid rafts by simvastatin after traumatic brain injury.

Journal of Neurosurgery — Fri, 06 Nov 2009 00:00:00 +0100

Conclusions These data suggest that simvastatin reduces reactive astrogliosis and rescues neuronal cells after TBI. These beneficial effects of simvastatin may be mediated by inhibiting astrocyte activation after TBI through modifying the caveolin-1 expression in lipid rafts and the subsequent modulation of EGFR phosphorylation in lipid rafts. PMID: 19895202 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Transfer of supinator motor branches to the posterior interosseous nerve in C7-T1 brachial plexus palsy.

Journal of Neurosurgery — Fri, 06 Nov 2009 00:00:00 +0100

Conclusions Transferring supinator motor nerves directly to the posterior interosseous nerve is effective in at least partially restoring thumb and finger extension in patients with lower-type injuries of the brachial plexus. PMID: 19895203 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)

Microsurgical removal of Onyx HD-500 from an aneurysm for relief of brainstem compression.

Journal of Neurosurgery — Fri, 06 Nov 2009 00:00:00 +0100

Authors: Van Loock K, Menovsky T, Voormolen MH, Plazier M, Parizel P, De Ridder D, Maas AI, Hernesniemi JA The authors report the successful removal of Onyx HD-500 from an aneurysm sac by means of ultrasonic aspiration. This 46-year-old woman presented with progressive spasms of her left arm and leg due to mass effect and compression on the right cerebral peduncle 5 years after endovascular treatment of an unruptured giant posterior communicating artery aneurysm with Onyx HD-500. No filling of the aneurysm was detected on angiography. The patient underwent a right pterional craniotomy and the aneurysm was opened to remove the Onyx mass. However, contrary to expectations, the aneurysm was still patent, filling with blood between the Onyx mass and the aneurysm wall. Under temporary clipp...

Puusepp's sign—Clinical significance of a forgotten pyramidal sign

Clinical Neurology and Neurosurgery — Wed, 04 Nov 2009 16:46:57 +0100

Abstract: The pyramidal signs in the lower extremity can be divided into three groups: (1) Babinski's group characterised by dorsoflexion of the great toe, (2) pyramidal signs marked by plantar flexion of the toes (e.g. Rossolimo's sign), and (3) synkinetic movements such as Strümpell's phenomenon. Puusepp's sign described by the Estonian neurologist and neurosurgeon Ludvig Puusepp belongs to none of these three groups. Its eliciting does not differ from that of Babinski's sign. The response, however, is different and consists of a tonic slow abduction of the little toe. We showed its relevance on the basis of clinical examination of six patients: four females aged 29, 50, 43 and 57 years and two males aged 42 and 49 years. The diagnoses were as follows: a new relapse of multiple sclerosi...

Hydatid spinal cord compression revealing multivisceral hydatidosis

Clinical Neurology and Neurosurgery — Wed, 04 Nov 2009 16:46:56 +0100

We report a 13-year-old-girl, who was referred for progressive gait difficulty that had begun 20 days before with in addition paresthesiae in the feet. Clinical examination revealed a spastic paraparesis, with bilateral Babinski sign, a global and sensory loss at T9–T10 level, and percussion of the spinal processes of D6 elicited pain. MRI of the spine revealed a cystic lesion involving the T4 and T5 vertebras on the left, with one process extending into the extradural space compressing the spinal cord () and many further other cystic lesions in the liver (stage III). Chest X-ray showed posterior and left mediastinal opacity with calcifications. Ultrasound of the abdomen confirmed the polycystic images in the liver. The indirect immunofluorescent antibody test for hydatid disease was neg...

Endovascular treatment for moyamoya disease in a Caucasian twin with angioplasty and Wingspan stent

Clinical Neurology and Neurosurgery — Wed, 04 Nov 2009 16:46:56 +0100

Abstract: The pathogenesis and genetics of moyamoya disease (MMD) remain a mystery. Here we report a case of female Caucasian adult twins with similar presentations of bilateral MMD that were treated with different surgical modalities. One twin was treated with a bypass and remains event free (defined as either transient ischemic event or stroke) at her 4-year follow-up. The second twin underwent angioplasty to treat a left middle cerebral artery stenosis as well as the placement of a Wingspan stent to treat a right supraclinoid ICA stenosis on separate occasions. The left middle cerebral artery angioplasty thrombosed due to the discontinuation of clopidogrel resulting in recurrent symptoms, principally aphasia, and the Wingspan stent underwent angioplasty for in-stent stenosis. Despite th...

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Primary intracranial leiomyomas: Report of two cases and review of the literature

Clinical Neurology and Neurosurgery — Wed, 04 Nov 2009 16:46:56 +0100

In this study, we present two cases of primary intracranial leiomyomas in middle-aged men. Magnetic resonance images (MRI) showed lesions with homogeneous low signals on T1-, T2-, diffusion-weighted, and FLAIR sequences. Tumors were totally removed and there was no evidence of recurrence in the follow-up study. Pathological analysis with immunohistochemistry revealed that tumors had characteristics of benign smooth muscles. A review of relevant literature has been conducted. (Source: Clinical Neurology and Neurosurgery)

Multiple bilateral non-hemorrhagic cerebral infarctions associated with microscopic polyangiitis

Clinical Neurology and Neurosurgery — Wed, 04 Nov 2009 16:46:56 +0100

We report a case of MPA with multiple bilateral non-hemorrhagic cerebral infarctions in a 66-year-old woman who was undergoing steroid pulse therapy. The diagnosis of MPA was based on the presence of painful mononeuritis multiplex, pulmonary fibrosis, and increased myeloperoxidase activity and on the biopsy of the sural nerve. (Source: Clinical Neurology and Neurosurgery)

Pseudohypoxic brain swelling after elective clipping of an unruptured anterior communicating artery aneurysm

Clinical Neurology and Neurosurgery — Wed, 04 Nov 2009 16:46:56 +0100

Abstract: A case of pseudohypoxic brain swelling, a newly defined entity, is described. The patient experienced generalized seizures and did not awake initially after a seemingly uneventful elective craniotomy for clipping of an unruptured anterior communicating artery aneurysm. Neuroimaging findings demonstrated diffuse brain swelling, especially in the bilateral basal ganglia and thalami. The rarity of this postoperative complication is addressed and the pathogenesis discussed. (Source: Clinical Neurology and Neurosurgery)

Multiple forms of rhythmic movements in an adolescent boy with rhythmic movement disorder

Clinical Neurology and Neurosurgery — Wed, 04 Nov 2009 16:46:56 +0100

This report raises the fact that a patient with RMD may present with multiple complex rhythmic movements disrupting sleep, which emphasizes that better understanding of the clinical features of complex rhythmic movements during sleep in primary care settings is essential for early clinical diagnosis and optimal management. (Source: Clinical Neurology and Neurosurgery)

Epidural hematoma revealed by exophthalmia, two cases reports

Clinical Neurology and Neurosurgery — Wed, 04 Nov 2009 16:46:56 +0100

We report on two cases of frontal epidural hematoma revealed by an exophthalmia after a minor head trauma. On reporting our cases we aim to increase the awareness of this association each time a head or facial trauma is associated with exophthalmia. (Source: Clinical Neurology and Neurosurgery)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Neuro-Behcet's disease presenting with amnesia and frontal dysfunction

Clinical Neurology and Neurosurgery — Wed, 04 Nov 2009 16:46:56 +0100

We report a 48-year-old patient with neuro-Behcet's disease who presented with the combination of severe memory impairment and frontal/executive dysfunction. The clinical feature mimicked that of diencephalic amnesic syndrome. The MRI and SPECT findings supported the notion that the thalamus and related subcortical–frontal connection was responsible for this patient's problem. (Source: Clinical Neurology and Neurosurgery)

Right-sided neglect influences the writing of Kanji: A case study

Clinical Neurology and Neurosurgery — Wed, 04 Nov 2009 16:46:56 +0100

Abstract: Neglect is the failure to report, respond, or orient to novel or meaningful stimuli presented to the side opposite a brain lesion. Here we describe the case of a 73-year-old woman who experienced a writing deficit in the right-sided component of Kanji letters (morphograms) of the Japanese language. Magnetic resonance imaging of the brain showed an infarction in the left middle temporal and occipital gyrus. The patient wrote recognizable, well-formed but paragraphic Kanji letters in both spontaneous and dictated writing. Most letters are composed of two elements: “hen” (left) and “tsukuri” (right). Neographism in tsukuri was her most frequent error. When she was instructed to answer orally hen and tsukuri, she made more mistakes related to tsukuri than to hen. Unilateral s...

Ziprasidone-related oculogyric crisis in an adult

Clinical Neurology and Neurosurgery — Wed, 04 Nov 2009 16:46:56 +0100

Conclusion: To the best of our knowledge, this is the first report of ziprasidone-related OGC in an adult patient. Physicians must be aware of its occurrence in order to improve care of patients treated with these agents. (Source: Clinical Neurology and Neurosurgery)

Characteristics of dystonia in the 18p deletion syndrome, including a new case

Clinical Neurology and Neurosurgery — Wed, 04 Nov 2009 16:46:56 +0100

Abstract: Objective of the present study was to evaluate the possible pathophysiology and clinical characteristics of dystonia in patients with the 18p deletion syndrome by describing a new case and reviewing the literature. Dystonia in patients with the 18p deletion syndrome seems to present heterogeneously with a variable age of onset and distribution of symptoms. It may be accompanied with white matter lesions on the MRI. Deletion of 2 known dystonia loci on chromosome 18p, DYT7 and DYT15, or the deletion of another dystonia gene just above the centromere of chromosome 18p may be the cause of dystonia in patients with the 18p deletion syndrome. However, dystonia may also be secondary to structural brain changes often seen in patients with the 18p deletion syndrome. (Source: Clinical Neu...

A case study of Neuro-psycho-Behçet's Syndrome presenting with psychotic attack

Clinical Neurology and Neurosurgery — Wed, 04 Nov 2009 16:46:56 +0100

Abstract: Behçet's disease is a multisystem inflammatory disorder that presents with a classic triad of recurrent oral and genital ulcerations and uveitis with hypopyon. The initial symptom of Behçet's disease is neurological in only 3% of cases. Although Neuro-Behçet's Syndrome commonly presents with focal neurological symptoms, it is possible that psychiatric symptoms could be the first manifestation of the disease. To our knowledge, this is the first case report of Neuro-Behçet's Syndrome that presents with an acute psychotic attack. (Source: Clinical Neurology and Neurosurgery)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Cervical spondylotic amyotrophy presenting as dropped head syndrome

Clinical Neurology and Neurosurgery — Wed, 04 Nov 2009 16:46:55 +0100

We report a case of acute-onset dropped head syndrome in a 65-year-old patient in whom the diagnosis of amyotrophic lateral sclerosis (ALS) was initially proposed based on electromyographic signs of neck and shoulder muscle denervation. There were no signs of pyramidal involvement and the clinical and electromyographic signs of motor denervation never evolved beyond the neck and shoulder girdle muscles after a 6-year follow-up period, which argued against ALS. Other causes of dropped head syndrome were carefully ruled out based on clinical findings, electrodiagnostic studies and blood investigations. The restriction of muscle denervation to a few cervical myotomes, the presence of C3–C4 spondylotic changes without associated root or spinal cord compression, and the absence of an alternat...

Successful endovascular reconstruction of acutely ruptured pseudoaneurysm of the vertebral artery, complicated by isolated vertebrobasilar circulation and symptomatic vasospasm

Clinical Neurology and Neurosurgery — Wed, 04 Nov 2009 16:46:55 +0100

Abstract: The management of a ruptured pseudoaneurysm of intracranial vertebral artery (VA), which is the sole supplier to an isolated vertebrobasilar system, is challenging. The authors report on such a case in a 49-year-old man who suffered a grade III subarachnoid hemorrhage (SAH) caused by a dissecting fusiform pseudoaneurysm of the left VA. The right VA terminated in the posterior inferior cerebellar artery and posterior communicating arteries were absent. The patient developed symptoms consistent with vasospasm on day 9 after SAH, which was treated by intra-arterial vasolytic therapy, followed by stent placement and “in-stent” balloon angioplasty. Angiography 2 weeks later showed near-complete resolution of the pseudoaneurysm. At discharge, the patient's modified Rankin score was...

Severe dopaminergic pathways damage in a case of chronic toluene abuse

Clinical Neurology and Neurosurgery — Wed, 04 Nov 2009 16:46:55 +0100

Conclusion: Clinical and neuroradiological findings and the possible sensitivity to neuroleptics indicate dopaminergic impairment. Our case suggests that chronic toluene abuse causes presynaptic dopaminergic depletion. (Source: Clinical Neurology and Neurosurgery)

Spontaneous cerebral calcific embolus from the aortic arch

Clinical Neurology and Neurosurgery — Wed, 04 Nov 2009 16:46:55 +0100

We report a case of stroke attributable to spontaneous calcific emboli from the aortic arch in which migration of the emboli was observed along the middle cerebral artery following iv tPA. (Source: Clinical Neurology and Neurosurgery)

Fractionated radiosurgical management of intramedullary spinal cord metastasis: A case report and review of the literature

Clinical Neurology and Neurosurgery — Wed, 04 Nov 2009 16:46:55 +0100

Conclusion: Fractionated stereotactic radiosurgery is a feasible, safe, and effective modality for the treatment of ICSM and should be carefully considered in the management of this difficult to treat condition. (Source: Clinical Neurology and Neurosurgery)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Frontal lobe atrophy is associated with small vessel disease in ischemic stroke patients

Clinical Neurology and Neurosurgery — Wed, 04 Nov 2009 16:46:55 +0100

Conclusion: Frontal lobe atrophy in ischemic stroke patients may be associated with small vessel disease. The association between WMLs and FLA was predominant over atrophy of the parietal and temporal lobes, which suggests that the frontal lobe may be vulnerable to subcortical ischemic changes. (Source: Clinical Neurology and Neurosurgery)

Plasma level of sICAM-1 is associated with the extent of white matter lesion among asymptomatic elderly subjects

Clinical Neurology and Neurosurgery — Wed, 04 Nov 2009 16:46:55 +0100

Abstract: Objective: Inflammatory endothelial activation mediated by intercellular adhesion molecule-1 (ICAM-1) plays a role in the pathogenesis of large- and small-vessel disease. We explored the association between soluble ICAM-1 (sICAM-1) and white matter lesion (WML) as a manifestation of cerebral small-vessel disease.Methods: One hundred and seventy-five elderly individuals aged ≥ 60 without neurological deficits were studied. Subcortical deep white matter hyperintensity (SDWMH) and periventricular hyperintensity (PVH) were rated separately. Lesions in each category were then divided into three groups (grade 0-I, grade II, grade III) according to the Fazekas scale.Results: Plasma sICAM-1 levels were positively associated with grades of WML (for SDWMH: 297.4±135.6ng/mL in grade 0-I,...

Intraoperative indocyanine green angiography in intracranial aneurysm surgery: Microsurgical clipping and revascularization

Clinical Neurology and Neurosurgery — Wed, 04 Nov 2009 16:46:55 +0100

Conclusion: ICG angiography can provide real-time information and guide revision in the same surgical procedure for the management of intracranial aneurysms. (Source: Clinical Neurology and Neurosurgery)

Stereotactic brain biopsy: Single center retrospective analysis of complications

Clinical Neurology and Neurosurgery — Wed, 04 Nov 2009 16:46:55 +0100

Conclusion: Stereotactic brain biopsy is a safe and reliable way to obtain a histological diagnosis. Based on our recent clinical experiences, the data suggests that more attention should be paid to liver cirrhotic patients, since the chance on hemorrhage is significantly larger. (Source: Clinical Neurology and Neurosurgery)

Evaluation of regional cerebral blood flow in cerebellar variant of multiple system atrophy using FineSRT

Clinical Neurology and Neurosurgery — Wed, 04 Nov 2009 16:46:54 +0100

Conclusion: We suggest that a widespread brain involvement is present in patients with MSA-C and the decreased rCBF in the pons may support the differential diagnosis between MSA-C and LCCA. (Source: Clinical Neurology and Neurosurgery)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Cerebral microbleeds predict first-ever symptomatic cerebrovascular events

Clinical Neurology and Neurosurgery — Wed, 04 Nov 2009 16:46:54 +0100

Conclusion: The presence of CMB is an independent predictor of first-ever symptomatic cerebrovascular diseases. (Source: Clinical Neurology and Neurosurgery)

The impact of fusion on adjacent levels in cervical spine injuries: Is it really important?

Clinical Neurology and Neurosurgery — Wed, 04 Nov 2009 16:46:54 +0100

Conclusion: Adjacent-level ossification in cervical spine injuries may appear very early in the postoperative period and it can have a different course than in the degenerative disc disease population, at least in some patients. The first cephalad level adjacent to a fusion appears to be at greater risk. However, even when ALOD is evident radiographically, it very rarely produces any symptoms. (Source: Clinical Neurology and Neurosurgery)

Prevalence of Parkinson's disease in Northern Jordan

Clinical Neurology and Neurosurgery — Wed, 04 Nov 2009 16:46:54 +0100

Conclusion: PD is a moderately prevalent disease in Jordan. The clinical characteristics of PD patients are similar to those reported in other countries. (Source: Clinical Neurology and Neurosurgery)

Correlation of glioma proliferation assessed by flow cytometry with 99mTc-Tetrofosmin SPECT uptake

Clinical Neurology and Neurosurgery — Wed, 04 Nov 2009 16:46:54 +0100

Conclusion: Initial evidence suggests that 99mTc-TF could provide a non-invasive indicator of glioma proliferative activity. (Source: Clinical Neurology and Neurosurgery)

Treatment of deep vascular orbital malformations

Clinical Neurology and Neurosurgery — Wed, 04 Nov 2009 16:46:54 +0100

Conclusions: Treatment of vascular malformations is required in case of progression of symptoms. In cases of visual deterioration, we generally favour early treatment. The least invasive surgical approach, tailored to the individual patient, should be chosen. (Source: Clinical Neurology and Neurosurgery)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Ultrastructure and immunohistochemistry of the trigeminal peripheral myelinated axons in patients with neuralgia

Clinical Neurology and Neurosurgery — Wed, 04 Nov 2009 16:46:54 +0100

Conclusions: The pathological changes affect not only the central nerve fibers of the TNR, but also some of the peripheral axons, their myelin sheath and Schwann cells. These are signs of the retrograde ultrastructural and biochemical alterations, which could participate in the pathophysiological mechanism underlying the trigeminal neuralgia. (Source: Clinical Neurology and Neurosurgery)

Machado-Joseph disease/SCA3 and myotonic dystrophy type 1 in a single patient

Clinical Neurology and Neurosurgery — Wed, 04 Nov 2009 16:46:54 +0100

We report here, for the first time, the case of a 41-year-old man with both Machado-Joseph disease (MJD)/spinocerebellar ataxia type 3 (SCA3) and myotonic dystrophy type 1. The patient noted dysarthria at 14 years of age and unsteady gait at 30 years of age. Similar sized expansions of the CAG trinucleotide repeats in one allele of the ataxin-3 (ATXN3) gene were found in both the patient and his father, although in the other allele the length of the CAG repeats was shorter in the father compared with the patient. In the dystrophia myotonica protein kinase (DMPK) gene the CTG repeats were much more expanded in the patient compared with his father. Thus it is possible that, in the farther, the short CAG repeat in the non-expanded ATXN3 allele delayed the onset of cerebellar symptoms, and/or ...

Editorial Board

Clinical Neurology and Neurosurgery — Wed, 04 Nov 2009 16:46:54 +0100

(Source: Clinical Neurology and Neurosurgery)

Response.

Journal of Neurosurgery — Sun, 01 Nov 2009 00:00:00 +0100

Authors: Noudel R PMID: 19891031 [PubMed - in process] (Source: Journal of Neurosurgery)

Response.

Journal of Neurosurgery — Sun, 01 Nov 2009 00:00:00 +0100

Authors: Mitsuhashi Y, Aurboonyawat T, Pereira VM, Geibprasert S, Toulgoat F, Ozanne A PMID: 19886001 [PubMed - in process] (Source: Journal of Neurosurgery)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Response.

Journal of Neurosurgery — Sun, 01 Nov 2009 00:00:00 +0100

Authors: Ferrell AS, Tubbs RS, Acakpo-Satchivi L PMID: 19886002 [PubMed - in process] (Source: Journal of Neurosurgery)

Response.

Journal of Neurosurgery — Sun, 01 Nov 2009 00:00:00 +0100

Authors: Samuelsson C, Howells T, Kumlien E, Enblad P, Hillered L, Ronne-Engström E PMID: 19886003 [PubMed - in process] (Source: Journal of Neurosurgery)

A review of therapeutic strategies for the management of cerebral venous sinus thrombosis.

Neurosurgical Focus — Sun, 01 Nov 2009 00:00:00 +0100

CONCLUSIONS: Effective treatments exist for the management of CVST, and overall outcomes are more favorable than those for arterial stroke. Further research is necessary to determine the role of individual therapies; however, the rarity of the condition poses a significant limitation. PMID: 19883208 [PubMed - in process] (Source: Neurosurgical Focus)

Introduction: Venous brain circulation disorders.

Neurosurgical Focus — Sun, 01 Nov 2009 00:00:00 +0100

Authors: Nakase H Brain ischemia by arterial occlusion has been a focus of attention for decades, and cerebral venous disorders have been an underestimated condition of potentially good outcome if diagnosed and treated promptly. Recently, there has been considerable interest in cerebral injury following cerebral venous circulation disorders because diagnosis has improved as our understanding of the diseases and modern imaging technologies have advanced. PMID: 19877787 [PubMed - in process] (Source: Neurosurgical Focus)

Microvascular decompression in patients with isolated maxillary division trigeminal neuralgia, with particular attention to venous pathology.

Neurosurgical Focus — Sun, 01 Nov 2009 00:00:00 +0100

Conclusions The authors confirmed that patients with isolated V2 TN were more likely to be female, tended toward an atypical pain classification with venous pathology at surgery, and fared just as well as those presenting with typical pain. PMID: 19877788 [PubMed - in process] (Source: Neurosurgical Focus)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Protecting venous structures during radiosurgery for parasagittal meningiomas.

Neurosurgical Focus — Sun, 01 Nov 2009 00:00:00 +0100

Authors: Conti A, Pontoriero A, Salamone I, Siragusa C, Midili F, La Torre D, Calisto A, Granata F, Romanelli P, De Renzis C, Tomasello F Symptomatic edema is a potential complication of meningioma radiosurgery. Parasagittal meningiomas are at a particular risk for symptomatic edema, suggesting a role for a venous occlusive complication. The authors sought to develop a strategy to optimize CyberKnife stereotactic radiosurgical treatment parameters to reduce the irradiation of the peritumoral venous system. Multislice CT venography with 3D reconstructions was performed and coregistered with thin-section, contrast-enhanced, volumetric MR images. The tumor and critical volumes were contoured on the MR images. Venous anatomical details obtained from the CT venographic study were then expor...

Spontaneous thrombosis of neonatal vein of Galen malformation.

Neurosurgical Focus — Sun, 01 Nov 2009 00:00:00 +0100

Authors: Moftakhar P, Danielpour M, Maya M, Alexander MJ Vein of Galen malformations are rare congenital intracranial vascular malformations. Based on reports in the literature, spontaneous thrombosis or regression of these lesions is rare. Patients have variable outcomes from an asymptomatic course to death. The reasons behind spontaneous thrombosis are not entirely understood. Here the authors present a case of an infant diagnosed with a vein of Galen malformation in utero that subsequently went on to thrombose or regress. A review of the published cases on this phenomenon and the potential causality are discussed. PMID: 19877790 [PubMed - in process] (Source: Neurosurgical Focus)

Endovascular embolization with Onyx in the management of sinus pericranii: a case report.

Neurosurgical Focus — Sun, 01 Nov 2009 00:00:00 +0100

Authors: Rangel-Castilla L, Krishna C, Klucznik R, Diaz O Sinus pericranii (SP) is an uncommon and usually asymptomatic communication between intra- and extracranial venous drainage pathways in which blood flow can circulate bidirectionally through abnormal dilated veins through a skull defect. Diagnosis and evaluation of the venous drainage pattern is important if treatment is contemplated. Cerebral angiography with the use of Dyna CT can be helpful in the diagnosis of SP and its relationship with the skull defect. The authors report what is, to the best of their knowledge, the first case of SP treated by means of endovascular embolization with Onyx. PMID: 19877791 [PubMed - in process] (Source: Neurosurgical Focus)

Efficacy of endovascular stenting in dural venous sinus stenosis for the treatment of idiopathic intracranial hypertension.

Neurosurgical Focus — Sun, 01 Nov 2009 00:00:00 +0100

Authors: Arac A, Lee M, Steinberg GK, Marcellus M, Marks MP Multiple pathophysiological mechanisms have been proposed for the increased intracranial pressure observed in idiopathic intracranial hypertension (IIH). The condition is well characterized, with intractable headaches, visual obscurations, and papilledema as dominant features, mainly affecting obese women. With the advent of MR venography and increased use of cerebral angiography, there has been recent emphasis on the significant number of patients with IIH found to have associated nonthrombotic dural venous sinus stenosis. This has led to a renewed interest in endovascular stenting as a treatment for IIH. However, the assumption that venous stenosis leads to a high pressure gradient that decreases CSF resorption through arach...

The diploic venous system: surgical anatomy and neurosurgical implications.

Neurosurgical Focus — Sun, 01 Nov 2009 00:00:00 +0100

Conclusions The pterional, orbitozygomatic, and supraorbital approaches place the FDV and ATDV at risk. The major anterior diploic system connects the SSS with the sphenoparietal sinus. The posterior diploic system connects the SSS with the transverse and sigmoid sinuses. PMID: 19877793 [PubMed - in process] (Source: Neurosurgical Focus)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Cerebral venous sinus thrombosis: review of the demographics, pathophysiology, current diagnosis, and treatment.

Neurosurgical Focus — Sun, 01 Nov 2009 00:00:00 +0100

Authors: Filippidis A, Kapsalaki E, Patramani G, Fountas KN Cerebral venous sinus thrombosis (CVST) is a rare clinicopathological entity. The incidence of CVST in children and neonates has been reported to be as high as 7 cases per million people, whereas in adults the incidence is 3-4 cases per million. The predisposing factors to this condition are mainly genetic and acquired prothrombotic states and infection. The clinical picture of CVST is nonspecific, highly variable, and can mimic several other clinical conditions. Diagnosis of CVST is established with the implementation of neuroimaging studies, especially MR imaging and venography. Identification and elimination of the underlying cause, anticoagulation, proper management of intracranial hypertension, and anticonvulsant prophyla...

From presentation to follow-up: diagnosis and treatment of cerebral venous thrombosis.

Neurosurgical Focus — Sun, 01 Nov 2009 00:00:00 +0100

Authors: Bentley JN, Figueroa RE, Vender JR Cerebral venous thrombosis is an uncommon cause of stroke but remains a challenge for physicians faced with this diagnosis largely due to the variability in presentation. Anticoagulation, typically with intravenous heparin, remains the mainstay of treatment for stable patients and is sufficient in the majority of cases. However, a significant mortality rate exists for cerebral venous thrombosis due to patients who deteriorate or do not adequately respond to initial treatments. It is in these patients that more aggressive interventions must be undertaken. The neurosurgeon is often called on, either acutely for initial evaluation of the stroke or venous hemorrhage or after the failure of initial therapy for clot evacuation, hemicraniectomy, or ...

Cerebral venous sinus thrombosis associated with oral contraceptives: the case for neurosurgery.

Neurosurgical Focus — Sun, 01 Nov 2009 00:00:00 +0100

Conclusions Cerebral venous sinus thrombosis secondary to oral contraception in young women, including lesions in critical and deep regions, can be treated medically with acceptable morbidity. In spite of this, a subgroup of patients needed basic neurosurgical management of the lesions, including surgical measures for controlling raised ICP. PMID: 19877796 [PubMed - in process] (Source: Neurosurgical Focus)

Direct thrombolysis for cerebral venous sinus thrombosis.

Neurosurgical Focus — Sun, 01 Nov 2009 00:00:00 +0100

Authors: Rahman M, Velat GJ, Hoh BL, Mocco J Cerebral venous sinus thrombosis (CVST) is an increasingly diagnosed disease with a wide range of symptoms, ranging from a mild headache to cerebral herniation. A potentially devastating syndrome, CVST has been associated with a mortality rate of 6-10%. In prospective studies, the overall rate of death and dependency from CVST ranges from 8.8 to 44.4%. Systemic anticoagulation remains the first-line treatment. However, a percentage of patients deteriorate despite medical therapy. These cases have resulted in the development of thrombolysis or endovascular treatment for CVST. Initial reports of the use of endovascular treatment of CVST have been promising. However, enthusiasm for the use of endovascular thrombolysis and thrombectomy should be...

Vein of Galen malformation.

Neurosurgical Focus — Sun, 01 Nov 2009 00:00:00 +0100

Authors: Hoang S, Choudhri O, Edwards M, Guzman R A vein of Galen malformation is a rare intracranial vascular lesion affecting the pediatric population. Its poor prognosis has been significantly improved with the development of endovascular embolization. In this paper the authors review the developmental mechanisms, clinical pathophysiology, and the available data on the management and outcome of the disease. PMID: 19877798 [PubMed - in process] (Source: Neurosurgical Focus)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

The putative role of the venous system in the genesis of vascular malformations.

Neurosurgical Focus — Sun, 01 Nov 2009 00:00:00 +0100

Authors: Aboian MS, Daniels DJ, Rammos SK, Pozzati E, Lanzino G Recent clinical and experimental evidence has challenged the traditional concept of the venous system as a "passive" element in the genesis and evolution of intracranial vascular malformations. The authors review the clinical and experimental evidence linking the venous system and its anomalies to the genesis of various intracranial vascular malformations, including dural arteriovenous fistulas, cavernous malformations, parenchymal arteriovenous malformations, and capillary telangiectasia. They also describe the potential significance of different associations of these vascular anomalies. PMID: 19877799 [PubMed - in process] (Source: Neurosurgical Focus)

Original paper Emery-Dreifuss dystrophy: a 4-year follow-up on a laminopathy of special interest

Fri, 30 Oct 2009 14:29:49 +0100

Conclusions: The intrafamilial and interfamilial variability of laminopathies is discussed in relation to interactions between nuclear proteins. Since the EDMD carrier state in females is associated with cardiac symptoms (without skeletal muscle involvement), systematic cardiological supervision is indicated. Likewise, there are certain patients presenting a typical EDMD phenotype in which no mutations in the EMD or LMNA genes can be confirmed. This may indicate that an Emery-Dreifuss-like dystrophy could also be associated with mutations in other genes. (Source: Articles of Polish Journal of Neurology and Neurosurgery - TERMEDIA publishing house)

Case report Epidural tuberculosis involving the entire spine

Fri, 30 Oct 2009 14:29:46 +0100

We discuss an elderly male who developed severe back pain, rapidly progressing paraparesis and urinary retention consequent to L5-S1 spinal tuberculosis with dissemination of epidural tubercular abscess and granulation tissue to the cervical, thoracic, lumbar and sacral region. The initial diagnosis of lumbo-sacral pathology with high thoracic extension was tackled by an L5 laminectomy and decompression along with saline flushing and evacuation of the thoraco-lumbar and sacral epidural abscess with the aid of a catheter passed superiorly and inferiorly. He developed neck pain and upper limb weakness subsequently and was found to have extensive extradural cervical compression by granulation tissue. He underwent C4-7 laminectomy and decompression of the cord. He was started on four-drug anti...

Original paper REM sleep behaviour disorder in narcolepsy

Fri, 30 Oct 2009 14:29:44 +0100

Conclusions: RBD occurs in narcolepsy more frequently than it was previously considered. Questions about symptoms of this disorder that may be injurious for the patient or patient’s bed partner should be routinely asked during the clinical interview. (Source: Articles of Polish Journal of Neurology and Neurosurgery - TERMEDIA publishing house)

Case report Clinical, pathological and radiological features of paraspinal textiloma: report of two cases and review of the literature

Fri, 30 Oct 2009 14:29:41 +0100

In this report, two additional cases with MR, CT and pathological features of paraspinal textilomas are described. CT image demonstrated a paraspinal mass simulating a malignant tumour. While T1-weighted MR images showed the masses with low signal intensity, T2-weighted MR images showed heterogeneous masses with low and high signal intensities. (Source: Articles of Polish Journal of Neurology and Neurosurgery - TERMEDIA publishing house)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Original paper Does amantadine have favourable effects on fatigue in Persian patients suffering from multiple sclerosis?

Fri, 30 Oct 2009 14:29:38 +0100

Conclusions: Our findings demonstrate a significant drop on the fatigue severity scale in MS patients after treatment with amantadine; nevertheless, more studies on a larger scale with longer duration are needed to confirm this finding. (Source: Articles of Polish Journal of Neurology and Neurosurgery - TERMEDIA publishing house)

Case Report Sphenoid wing meningioma and glioblastoma multiforme in collision – case report and review of the literature

Fri, 30 Oct 2009 14:29:35 +0100

We present the third case of a 73-year-old woman who underwent an uneventful excision of a right sphenoid wing meningioma. She was re-admitted 3 years later due to reappearance of a tumour in the area adjacent to the previously excised meningioma. Histological diagnosis revealed a collision tumour of a glioblastoma multiforme and a fibrillary meningioma. The coincidence of these two different neoplasms in the same location at the same time 3 years after surgical removal of a meningioma leads us to speculate on the pathogenesis, and to review the literature regarding this particular issue. (Source: Articles of Polish Journal of Neurology and Neurosurgery - TERMEDIA publishing house)

Original paper Comparison of the diagnostic value of ultrasonography and neurography in carpal tunnel syndrome

Fri, 30 Oct 2009 14:29:32 +0100

Conclusions: Ultrasonographic findings correlate well with electrophysiological tests in CTS patients. Cross-sectional area equal to 0.1 cm2 is important in CTS diagnostics. Median nerve oedema, revealed in the early stage of CTS without any electrophysiological changes, might be an important factor in occurrence of subjective complaints. Radial slide of median nerve phenomenon is a common ultrasonographic finding in CTS. (Source: Articles of Polish Journal of Neurology and Neurosurgery - TERMEDIA publishing house)

Original paper Index finger somatosensory evoked potentials in blind Braille readers

Fri, 30 Oct 2009 14:29:25 +0100

Conclusions: Blindness has a profound effect on the Braille reading right index finger. Totally blind Braille readers have larger N20 amplitude, suggestive of greater somatosensory cortical representation of the Braille reading index finger. (Source: Articles of Polish Journal of Neurology and Neurosurgery - TERMEDIA publishing house)

Review paper Optimisation of treatment of Parkinson’s disease with levodopa

Fri, 30 Oct 2009 14:29:22 +0100

This article presents the major strategies for individualisation and optimisation of levodopa therapy. The relationship between pharmacokinetic and pharmacodynamic effects of levodopa is discussed. Pharmacokinetic parameters in different stages of Parkinson’s disease are interpreted. Moreover, the main differences in pharmacokinetics of levodopa formulations and routes of administration are presented. The authors also suggest methods to increase efficacy and safety of levodopa therapy in patients with Parkinson’s disease. (Source: Articles of Polish Journal of Neurology and Neurosurgery - TERMEDIA publishing house)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Review paper Transcranial magnetic stimulation in the therapy of selected post-stroke cognitive deficits: aphasia and visuospatial hemineglect

Fri, 30 Oct 2009 14:29:18 +0100

Over the last several years functional neuroimaging studies and neurophysiological investigations have provided greater insight into the mechanisms underlying neuroplasticity and recovery after stroke. Various techniques became available for the non-invasive modulation of human brain activity and allowed better rehabilitation programmes to be designed. One of these new techniques is transcranial magnetic stimulation (TMS). It is a painless brain stimulation technique that modulates cortical activity. Regularly repeated TMS delivered to a single scalp position (repetitive TMS, rTMS) has an effect on cortical excitability that lasts beyond the duration of the rTMS applications. The effects of rTMS on cortical excitability may be inhibitory or facilitatory depending on stimulation parameters....

Case report Multiple mononeuropathy in the course of the Churg-Strauss syndrome – a case study

Fri, 30 Oct 2009 14:29:14 +0100

We present a case of a 60-year-old man with the CSS evolving in three phases. The initial symptoms included bronchial asthma and inflammation of the ethmoid sinuses. Later, the patient was diagnosed with peripheral blood eosinophilia, pulmonary changes, skin changes and neurological symptoms that progressed to multiple mononeuropathy. Electrophysiological tests confirmed progressive damage of the peripheral nervous system. An improvement of the patient’s neurological state was observed after application of corticosteroids and rehabilitation. CSS is one of the causes of multiple mononeuropathy and should be taken into account in differential diagnosis. In patients with bronchial asthma, hypereosinophilia and progressive damage of many nerves, the syndrome is diagnosed in accordance wi...

History of Polish Neurology and Neurosurgery Igor Klatzo (1916-2007) – co-founder of the Polish experimental school of nervous system research

Fri, 30 Oct 2009 14:28:42 +0100

(Source: Articles of Polish Journal of Neurology and Neurosurgery - TERMEDIA publishing house)

Komunikat

Fri, 30 Oct 2009 14:28:17 +0100

(Source: Articles of Polish Journal of Neurology and Neurosurgery - TERMEDIA publishing house)

What’s new in neurology

Fri, 30 Oct 2009 14:27:35 +0100

(Source: Articles of Polish Journal of Neurology and Neurosurgery - TERMEDIA publishing house)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Calendar Of Events

Fri, 30 Oct 2009 14:26:47 +0100

(Source: Articles of Polish Journal of Neurology and Neurosurgery - TERMEDIA publishing house)

Testowy program edukacyjny

Fri, 30 Oct 2009 14:26:34 +0100

(Source: Articles of Polish Journal of Neurology and Neurosurgery - TERMEDIA publishing house)

Alleviation of off-period dystonia in Parkinson disease by a microlesion following subthalamic implantation.

Journal of Neurosurgery — Fri, 30 Oct 2009 00:00:00 +0100

Conclusions The author postulated that off-period dystonia alleviation may reflect both a microsubthalamotomy and micropallidotomy effect. They hypothesize, moreover, that the microlesion could play a role in the 6-month postoperative outcome. PMID: 19877801 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)

Ultrahigh-dose intraarterial infusion of verapamil through an indwelling microcatheter for medically refractory severe vasospasm: initial experience.

Journal of Neurosurgery — Fri, 30 Oct 2009 00:00:00 +0100

Conclusions Prolonged intraarterial infusion of verapamil is a safe and effective treatment for medically refractory severe vasospasm and reduces the need for angioplasty in such cases. PMID: 19877802 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)

Slowly progressive neuronal death associated with postischemic hyperperfusion in cortical laminar necrosis after high-flow bypass for a carotid intracavernous aneurysm.

Journal of Neurosurgery — Fri, 30 Oct 2009 00:00:00 +0100

This report illustrates, for the first time, dynamic neuroradiological correlations between slowly progressive neuronal death shown by (123)I-IMZ SPECT and cortical laminar necrosis on MR imaging in human stroke. PMID: 19877803 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Editorial.

Journal of Neurosurgery — Fri, 30 Oct 2009 00:00:00 +0100

Authors: Samii M, Gerganov VM PMID: 19877804 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)

A modified far-lateral approach for large or giant meningiomas of the posterior fossa.

Journal of Neurosurgery — Fri, 30 Oct 2009 00:00:00 +0100

Conclusions A modified far-lateral approach to the posterior fossa and CPA allows for safe, and often total, resection of large meningiomas with minimal morbidity. While avoiding the risks of condylar resection, this microsurgical strategy allows for greater field of view, minimal venous bleeding, and immediate access to the spinal subarachnoid space. PMID: 19877805 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)

Choosing the best operation for chronic subdural hematoma: a decision analysis.

Journal of Neurosurgery — Fri, 30 Oct 2009 00:00:00 +0100

Conclusions Bur-hole craniostomy is the most efficient choice for surgical drainage of uncomplicated CSDH. Bur-hole craniostomy balances a low recurrence rate with a low incidence of highly morbid complications. Decision analysis provides statistical and empirical guidance in the absence of well-controlled large trials and despite a confusing range of previously reported morbidity and recurrence. PMID: 19877806 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)

Recurrence rates after neuroendoscopic fenestration and Gamma Knife surgery in comparison with subtotal resection and Gamma Knife surgery for the treatment of cystic craniopharyngiomas.

Journal of Neurosurgery — Fri, 30 Oct 2009 00:00:00 +0100

Conclusions This investigation confirms that STR followed by GKS results in a lower recurrence rate than neuroendoscopy and GKS. Neuroendoscopy and GKS, however, results in a better preservation of endocrine function. These results suggest that a generalized multimodal approach including endoscopic fenestration in addition to GKS is hindered by higher recurrence rates. PMID: 19877807 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)

Posters

Journal of Neurology, Neurosurgery & Psychiatry — Wed, 28 Oct 2009 22:41:40 +0100

(Source: Journal of Neurology, Neurosurgery & Psychiatry)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Case presentations

Journal of Neurology, Neurosurgery & Psychiatry — Wed, 28 Oct 2009 22:41:40 +0100

(Source: Journal of Neurology, Neurosurgery & Psychiatry)

ABN joint annual meeting 2009 with the Spanish Society of Neurology

Journal of Neurology, Neurosurgery & Psychiatry — Wed, 28 Oct 2009 22:41:40 +0100

(Source: Journal of Neurology, Neurosurgery & Psychiatry)

Treatment of musical hallucinosis with acetylcholinesterase inhibitors

Journal of Neurology, Neurosurgery & Psychiatry — Wed, 28 Oct 2009 22:41:39 +0100

(Source: Journal of Neurology, Neurosurgery & Psychiatry)

Corticobasal syndrome associated with a novel 1048_1049insG progranulin mutation

Journal of Neurology, Neurosurgery & Psychiatry — Wed, 28 Oct 2009 22:41:39 +0100

(Source: Journal of Neurology, Neurosurgery & Psychiatry)

Coexistence of chronic inflammatory demyelinating polyneuropathy and camptocormia

Journal of Neurology, Neurosurgery & Psychiatry — Wed, 28 Oct 2009 22:41:39 +0100

(Source: Journal of Neurology, Neurosurgery & Psychiatry)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Strong association between myotonic dystrophy type 2 and autoimmune diseases

Journal of Neurology, Neurosurgery & Psychiatry — Wed, 28 Oct 2009 22:41:39 +0100

Conclusion: The results provide new insight into the clinical picture of DM2. In addition, possible explanations for the association between DM2 and autoimmune diseases are proposed. (Source: Journal of Neurology, Neurosurgery & Psychiatry)

Episodic ataxia type 2: unusual aspects in clinical and genetic presentation. Special emphasis in childhood

Journal of Neurology, Neurosurgery & Psychiatry — Wed, 28 Oct 2009 22:41:39 +0100

Conclusion: EA2 may present with still unknown genetic mutations in adults, and with large and various phenotypes in children, such as short attacks of imbalance or permanent imbalance, cognitive deficiency, and possibly strabismus and hyperactivity. (Source: Journal of Neurology, Neurosurgery & Psychiatry)

A novel TARDBP mutation in an Australian amyotrophic lateral sclerosis kindred

Journal of Neurology, Neurosurgery & Psychiatry — Wed, 28 Oct 2009 22:41:39 +0100

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder that causes loss of motor neurons. A pathological hallmark of ALS is the presence of ubiquitinated TAR DNA binding protein (TDP-43) inclusions in the cytoplasm of affected cells. Rare pathogenic mutations within the gene TARDBP that encode TDP-43 were recently reported in ALS but their functional consequences are unknown. To further investigate the pathogenic role of TDP-43 in ALS, a mutation analysis of TARDBP was performed in an Australian cohort of 74 sporadic and 30 familial ALS cases. A novel familial ALS mutation in TDP-43 was identified that substitutes a highly conserved residue (G294V) and is predicted to disrupt the glycine rich domain in the C terminus, a region that plays a role in RNA binding and is requ...

TARDBP in amyotrophic lateral sclerosis: identification of a novel variant but absence of copy number variation

Journal of Neurology, Neurosurgery & Psychiatry — Wed, 28 Oct 2009 22:41:39 +0100

Conclusions: The findings stress the importance of TDP-43 in the pathogenesis of sporadic ALS. (Source: Journal of Neurology, Neurosurgery & Psychiatry)