MedWorm: Perinatology & Neonatology Top 20

School attainment of children who had a single umbilical artery at birth

Paediatric and Perinatal Epidemiology — Fri, 26 Feb 2010 00:00:00 +0100

In conclusion the children born with SUA are more likely than children born with three vessels to show impaired school achievements. (Source: Paediatric and Perinatal Epidemiology)

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Effect of Magnesium Sulfate Concentration on Serum Ionized Magnesium In Vitro

American Journal of Perinatology — Tue, 23 Feb 2010 16:44:10 +0100

Amer J PerinatolDOI: 10.1055/s-0030-1248938ABSTRACTWe undertook this in vitro study to quantify the effect that addition of magnesium (Mg) sulfate to neonatal serum, as compared with adult serum, might have on ionized Mg (Mg) concentration. We used one cord blood sample and one adult blood sample that we made hypermagnesemic by adding various amounts of magnesium sulfate to study five levels of serum Mg. Each sample was then studied at one of three levels of pH, from extreme alkalosis to extreme acidosis. We measured the changes in serum Mg and serum ionized calcium (Ca) in reaction to these changes in pH and Mg. At each pH level, there was an exponential increase in the serum Mg (and no significant change in serum Ca) with increasing serum Mg. Multiple regression analysis using Mg as the ...

Neonatal Outcomes in Twin Pregnancies Delivered Moderately Preterm, Late Preterm, and Term

American Journal of Perinatology — Sat, 20 Feb 2010 16:25:36 +0100

Amer J PerinatolDOI: 10.1055/s-0030-1248940ABSTRACTWe compared neonatal outcomes in twin pregnancies following moderately preterm birth (MPTB), late preterm birth (LPTB), and term birth. A secondary analysis of a multicenter, randomized controlled trial of multiple gestations was conducted. MPTB was defined as delivery between 32/ and 33/ weeks and LPTB between 34/ and 36/ weeks. Primary outcome was a neonatal outcome composite consisting of one or more of the following: neonatal death, respiratory distress syndrome, early onset culture-proven sepsis, stage 2 or 3 necrotizing enterocolitis, bronchopulmonary dysplasia, grade 3 or 4 intraventricular hemorrhage, periventricular leukomalacia, pneumonia, or severe retinopathy of prematurity. Among 552 twin pregnancies, the MPTB rate was 14.5%, ...

Metabolic parameters and perinatal outcomes of gestational diabetes mellitus in women with polycystic ovary syndrome

Journal of Perinatal Medicine — Thu, 04 Mar 2010 18:11:25 +0100

Journal of Perinatal Medicine 38 (2): 141-146 Abstract Aims: To investigate metabolic characteristics and perinatal outcomes of gestational diabetes mellitus (GDM) in women with polycystic ovary syndrome (PCOS). Methods: We evaluated 34 GDM in women with PCOS and 70 GDM in women without PCOS in this prospective study. All GDM women were treated with medical nutrition therapy (MNT). Pre-pregnancy clinical data, fasting glucose, fasting insulin (FINS), blood lipid, homeostasis model assessment index of insulin resistance (HOMA-IR) and perinatal outcomes were investigated. Results: GDM in women with PCOS had higher pre-pregnancy body mass index (BMI), higher incidence of overweight than in the non-PCOS group (each P (Source: Journal of Perinatal Medicine)

Recurrence Risk of a Delivery before 34 Weeks of Pregnancy Due to an Early Onset Hypertensive Disorder: A Systematic Review

American Journal of Perinatology — Sat, 20 Feb 2010 16:25:36 +0100

Amer J PerinatolDOI: 10.1055/s-0030-1248944ABSTRACTEarly onset hypertensive disorders of pregnancy are associated with adverse maternal and neonatal outcome. The risk of recurrence influences parents' choices on subsequent pregnancies and the counseling obstetrician, but evidence so far has been limited. We performed the first systematic review on the risk of recurrence of hypertensive disorders that had caused delivery <34 weeks. We searched Medline, Embase, and the Cochrane Library for articles published until September 2009 that report on pregnancy outcome after an earlier pregnancy complicated by early hypertension, preeclampsia, or hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome, which resulted in a delivery before 34 weeks. Recurrence rates of premature deliverie...

Newborn and Infant Nursing Reviews — Mon, 22 Feb 2010 16:47:41 +0100

(Source: Newborn and Infant Nursing Reviews)

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Potential Pitfalls in Collecting and Analyzing Longitudinal Data From Chronically Ill Populations

Newborn and Infant Nursing Reviews — Mon, 22 Feb 2010 16:47:41 +0100

This article will examine four major pitfalls: selection of time points, measurement, choosing appropriate statistical procedures, and missing values. Although the frequency of data collection is often driven primarily by practical concerns, it will affect the results. In addition, outcome measures may capture different constructs at different points in times. Traditional analysis techniques often have assumptions about data characteristics that are violated in clinical populations. Missing values are common in research with chronically ill individuals because of problems of subject retention and because individuals have frequent medical complications. Solutions to these pitfalls are also discussed. (Source: Newborn and Infant Nursing Reviews)

Quantitative Research Methodology: Common Pitfalls and Recommended Solutions

Newborn and Infant Nursing Reviews — Mon, 22 Feb 2010 16:47:41 +0100

Quantitative research methodology, which is characterized by positivism, measurement, and statistics, has dominated the scientific literatures in many disciplines. Clinical research, in particular, often relies on quantitative data to describe, predict, and explain the complex phenomena at work. Other disciplines sometimes turn to medical paradigms as learning models and benchmark standards for improving scientific rigor and assessing intellectual merit. (Source: Newborn and Infant Nursing Reviews)

Outcome in Second- versus First-Stage Cesarean Delivery in a Teaching Institution in Eastern India

American Journal of Perinatology — Sat, 20 Feb 2010 16:25:36 +0100

Amer J PerinatolDOI: 10.1055/s-0030-1248936ABSTRACTWe evaluated the maternal and perinatal complications of cesarean delivery performed in the second stage compared with the first stage of labor in nulliparous women. We performed a hospital-based cohort study in a teaching institution in Kolkata, West Bengal, India. The primary maternal outcomes measured included intraoperative surgical complications, duration of surgery, need for blood transfusion, wound infection, transfer to intensive care unit, and length of hospital stay. The neonatal outcomes included 5-minute Apgar score 3 or less, need for endotracheal intubation, admission to neonatal intensive care unit, fetal injury, septicemia, neonatal seizures, and neonatal death. There were 1702 cesarean deliveries performed in the first sta...

Trauma in Pregnancy: A Systematic Approach

American Journal of Perinatology — Wed, 03 Mar 2010 16:33:38 +0100

Amer J PerinatolDOI: 10.1055/s-0030-1249358ABSTRACTTrauma in pregnancy remains one of the major contributors to maternal and fetal morbidity and mortality. Potential complications include maternal injury or death, shock, internal hemorrhage, intrauterine fetal demise, direct fetal injury, abruptio placentae, and uterine rupture. The leading causes of obstetric trauma are motor vehicle accidents, falls, assaults, and gunshots, and ensuing injuries are classified as blunt abdominal trauma, pelvic fractures, or penetrating trauma. Many of the assessment and management aspects of obstetric trauma are unique to pregnancy, although initial evaluation and resuscitation should always be maternally directed. Once maternal stability is established, vigilant evaluation of fetal well-being becomes war...

A successful pregnancy following transcervical CVS related GBS sepsis

Prenatal Diagnosis — Fri, 26 Feb 2010 00:00:00 +0100

No Abstract. (Source: Prenatal Diagnosis)

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Differences in exposure assignment between conception and delivery: the impact of maternal mobility

Paediatric and Perinatal Epidemiology — Fri, 26 Feb 2010 00:00:00 +0100

Lupo PJ, Symanski E, Chan W, Mitchell LE, Waller DK, Canfield MA, Langlois PH. Differences in exposure assignment between conception and delivery: the impact of maternal mobility. Paediatric and Perinatal Epidemiology 2010; 24: 200[ndash]208. In studies of reproductive outcomes, maternal residence at delivery is often the only information available to characterise environmental exposures during pregnancy. The goal of this investigation was to describe residential mobility during pregnancy and to assess the extent to which change of residence may result in exposure misclassification when exposure is based on the address at delivery. Maternal residential mobility was compared between neural tube defect cases and unaffected controls from Texas participants in the National Birth Defects Preven...

Deletion of Hepatocyte Nuclear Factor-1-Beta in an Infant with Prune Belly Syndrome

American Journal of Perinatology — Sat, 20 Feb 2010 16:25:36 +0100

Amer J PerinatolDOI: 10.1055/s-0030-1248943ABSTRACTPrune belly syndrome is a rare congenital disorder characterized by deficiency of abdominal wall muscles, cryptorchidism, and urinary tract anomalies. We have had the opportunity to study a baby with prune belly syndrome associated with an apparently de novo 1.3-megabase interstitial 17q12 microdeletion that includes the hepatocyte nuclear factor-1-β gene at 17q12. One previous patient, an adult, has been reported with prune belly syndrome and a hepatocyte nuclear factor-1-β microdeletion. Hepatocyte nuclear factor-1-β is a widely expressed transcription factor that regulates tissue-specific gene expression and is expressed in numerous tissues including mesonephric duct derivatives, the renal tubule of the metanephros, and t...

Antepartum and Intrapartum Risk Factors for Neonatal Encephalopathy at Term

American Journal of Perinatology — Fri, 12 Mar 2010 16:23:07 +0100

In conclusion, 44% of cases of NE following term deliveries can be attributed to a combination of antepartum and intrapartum variables.[...]© Thieme Medical PublishersGet connected:Table of contents | Abstract | Full text (Source: American Journal of Perinatology)

Quantitative analysis of magnetic resonance images and neurological outcome in encephalopathic neonates treated with whole-body hypothermia

Journal of Perinatology — Thu, 25 Feb 2010 00:00:00 +0100

Authors: A N Massaro, N Kadom, T Chang, P Glass, K Nelson & S Baumgart (Source: Journal of Perinatology)

Risk of fever and sepsis evaluations after routine immunizations in the neonatal intensive care unit

Journal of Perinatology — Thu, 25 Feb 2010 00:00:00 +0100

Authors: A M Navar-Boggan, N A Halsey, W C Golden, G J Escobar, M Massolo & N P Klein (Source: Journal of Perinatology)

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Mifepristone-induced abortion and duration of third stage labour in a subsequent pregnancy

Paediatric and Perinatal Epidemiology — Fri, 26 Feb 2010 00:00:00 +0100

In conclusion, the data did not provide evidence that one MA was associated with the risk of prolonged third stage of labour in a subsequent pregnancy in primiparae. (Source: Paediatric and Perinatal Epidemiology)

Variability in Duration of Outpatient Diuretic Therapy in Bronchopulmonary Dysplasia: A Clinical Experience

American Journal of Perinatology — Tue, 23 Feb 2010 03:14:44 +0100

This study demonstrated great variability in the duration of diuretic therapy and diuretic taper. Discharge on oxygen was associated with longer duration of diuretic therapy and taper. Active taper is successful in the majority of patients and should be considered in patients with stable BPD.[...]© Thieme Medical PublishersGet connected:Table of contents | Abstract | Full text (Source: American Journal of Perinatology)

Newborn and Infant Nursing Reviews — Mon, 22 Feb 2010 16:47:41 +0100

W hile research topics are the theme of this issue, neonatal intensive care unit nurses' knowledge and experience with qualitative and quantitative research vary greatly. As new graduate nurses are entering the neonatal intensive care unit, the need for a consistent, evidence-based practice and knowledge of this is crucial. The effective practice of nursing is a balance between personal experience, best available clinical evidence, and logic or common sense. Sackett defined evidence-based practice as “the use of clinical experience combined with current best evidence to make decisions about the care of individual patients.” This definition implies that evidence-based practice has three components. These components would be the clinical expertise of the health care provider, the needs o...

Treatment of persistent patent ductus arteriosus in preterm infants: time to accept the null hypothesis?

Journal of Perinatology — Thu, 25 Feb 2010 00:00:00 +0100

Treatment of persistent patent ductus arteriosus in preterm infants: time to accept the null hypothesis? Journal of Perinatology advance online publication, February 25, 2010. doi:10.1038/jp.2010.3 Author: W E Benitz (Source: Journal of Perinatology)

MedWorm: Perinatology & Neonatology Top 20

School attainment of children who had a single umbilical artery at birth

Effect of Magnesium Sulfate Concentration on Serum Ionized Magnesium In Vitro

Neonatal Outcomes in Twin Pregnancies Delivered Moderately Preterm, Late Preterm, and Term

Metabolic parameters and perinatal outcomes of gestational diabetes mellitus in women with polycystic ovary syndrome

Recurrence Risk of a Delivery before 34 Weeks of Pregnancy Due to an Early Onset Hypertensive Disorder: A Systematic Review

Contents

Potential Pitfalls in Collecting and Analyzing Longitudinal Data From Chronically Ill Populations

Quantitative Research Methodology: Common Pitfalls and Recommended Solutions

Outcome in Second- versus First-Stage Cesarean Delivery in a Teaching Institution in Eastern India

Trauma in Pregnancy: A Systematic Approach

A successful pregnancy following transcervical CVS related GBS sepsis

Differences in exposure assignment between conception and delivery: the impact of maternal mobility

Deletion of Hepatocyte Nuclear Factor-1-Beta in an Infant with Prune Belly Syndrome

Antepartum and Intrapartum Risk Factors for Neonatal Encephalopathy at Term

Quantitative analysis of magnetic resonance images and neurological outcome in encephalopathic neonates treated with whole-body hypothermia

Risk of fever and sepsis evaluations after routine immunizations in the neonatal intensive care unit

Mifepristone-induced abortion and duration of third stage labour in a subsequent pregnancy

Variability in Duration of Outpatient Diuretic Therapy in Bronchopulmonary Dysplasia: A Clinical Experience

Treatment of persistent patent ductus arteriosus in preterm infants: time to accept the null hypothesis?