MedWorm: Perinatology & Neonatology

First-trimester use of paroxetine and congenital heart defects: A population-based case-control study

Birth Defects Research Part A: Clinical and Molecular Teratology — Sat, 21 Nov 2009 00:00:00 +0100

There is a need for case-control studies of the effect of paroxetine on the occurrence of specific heart defects.We performed a case-control study with data from a population-based birth defects registry in the Netherlands. All the children born between 1997 and 2006 were selected. Cases were defined as fetuses and children with isolated heart defects, and the controls were fetuses and children with a genetic disorder with no heart defect. We excluded children for whom there was no information on maternal medication use and deceased children and fetuses who were not examined postmortem. First-trimester exposure to paroxetine was compared between cases and controls by calculating adjusted odds ratios (AOR).We included 678 cases with isolated heart defects and 615 controls. The first trimest...

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Arterial Cord Blood Lactate at Birth Correlates with Duration of Pushing Efforts

Fetal Diagnosis and Therapy — Fri, 20 Nov 2009 23:00:00 +0100

Fetal Diagn Ther (DOI:10.1159/000261504) (Source: Fetal Diagnosis and Therapy)

Testing reported associations of genetic risk factors for oral clefts in a large Irish study population

Birth Defects Research Part A: Clinical and Molecular Teratology — Fri, 20 Nov 2009 00:00:00 +0100

Suggestive, but not conclusive, studies implicate many genetic variants in oral cleft etiology. We used a large, ethnically homogenous study population to test whether reported associations between nonsyndromic oral clefts and 12 genes (CLPTM1, CRISPLD2, FGFR2, GABRB3, GLI2, IRF6, PTCH1, RARA, RYK, SATB2, SUMO1, TGFA) could be confirmed.Thirty-one single nucleotide polymorphisms (SNPs) in exons, splice sites, and conserved non-coding regions were studied in 509 patients with cleft lip with or without cleft palate (CLP), 383 with cleft palate only (CP), 838 mothers and 719 fathers of patients with oral clefts, and 902 controls from Ireland. Case-control and family-based statistical tests were performed using isolated oral clefts for the main analyses.In case-control comparisons, the minor a...

Hypothesis: Could Epstein-Barr virus play a role in the development of gastroschisis?

Birth Defects Research Part A: Clinical and Molecular Teratology — Fri, 20 Nov 2009 00:00:00 +0100

The strong inverse association between maternal age and risk of gastroschisis in offspring has spurred many investigators to hypothesize that behaviors among younger females are the cause. Examples include cigarette smoking, illicit drugs, genitourinary infections, and sexually transmitted diseases, each of which has been reported to be associated with gastroschisis. Although these exposures are more common in young women, recent studies have shown that cigarette smoking, genitourinary infections, and sexually transmitted diseases are most strongly associated with gastroschisis in older women. There is both anecdotal and published evidence showing that gastroschisis sometimes (but not always) occurs in clusters, raising the possibility that an infectious agent might be involved in its path...

Management of Pregnancy with Poor Intrauterine Fetal Growth

Fetal Diagnosis and Therapy — Thu, 19 Nov 2009 23:00:00 +0100

Fetal Therapy 1986;1:129-130 (DOI:10.1159/000262257) (Source: Fetal Diagnosis and Therapy)

Intrauterine Growth Retardation: Clinical Problems in the Management of the Small-for-Date Baby

Fetal Diagnosis and Therapy — Thu, 19 Nov 2009 23:00:00 +0100

Fetal Therapy 1986;1:131-133 (DOI:10.1159/000262258) (Source: Fetal Diagnosis and Therapy)

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Pregnancy Outcome following Ultrasound Diagnosis of Fetal Urinary Tract Anomalies and/or Oligohydramnios

Fetal Diagnosis and Therapy — Thu, 19 Nov 2009 23:00:00 +0100

Fetal Therapy 1986;1:134-145 (DOI:10.1159/000262259) (Source: Fetal Diagnosis and Therapy)

Is the Intrauterine Treatment of Fetal Hydrocephalus Helpful or Harmful?

Fetal Diagnosis and Therapy — Thu, 19 Nov 2009 23:00:00 +0100

Fetal Therapy 1986;1:146-149 (DOI:10.1159/000262260) (Source: Fetal Diagnosis and Therapy)

Primates and Anencephalics as Sources for Pediatric Organ Transplants

Fetal Diagnosis and Therapy — Thu, 19 Nov 2009 23:00:00 +0100

Fetal Therapy 1986;1:150-164 (DOI:10.1159/000262261) (Source: Fetal Diagnosis and Therapy)

Contents, Vol. 1, 1986

Fetal Diagnosis and Therapy — Thu, 19 Nov 2009 23:00:00 +0100

Fetal Therapy 1986;1:I (DOI:10.1159/000262262) (Source: Fetal Diagnosis and Therapy)

Editorial

Fetal Diagnosis and Therapy — Thu, 19 Nov 2009 23:00:00 +0100

Fetal Therapy 1986;1:165-167 (DOI:10.1159/000262263) (Source: Fetal Diagnosis and Therapy)

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Effect of Gestational Age on Fetal and Intervillous Blood Gas and Acid-Base Values in Human Pregnancy

Fetal Diagnosis and Therapy — Thu, 19 Nov 2009 23:00:00 +0100

Fetal Therapy 1986;1:168-175 (DOI:10.1159/000262264) (Source: Fetal Diagnosis and Therapy)

Utero-Placental Blood Velocity Resistance Index and Umbilical Venous pO 2 , pCO 2 , pH, Lactate and Erythroblast Count in Growth-Retarded Fetuses

Fetal Diagnosis and Therapy — Thu, 19 Nov 2009 23:00:00 +0100

Fetal Therapy 1986;1:176-179 (DOI:10.1159/000262265) (Source: Fetal Diagnosis and Therapy)

Intrauterine Exchange Transfusion of the Fetus under Ultrasound Guidance: First Successful Report

Fetal Diagnosis and Therapy — Thu, 19 Nov 2009 23:00:00 +0100

Fetal Therapy 1986;1:180-184 (DOI:10.1159/000262266) (Source: Fetal Diagnosis and Therapy)

Rh Disease: Intravascular Fetal Blood Transfusion by Cordocentesis

Fetal Diagnosis and Therapy — Thu, 19 Nov 2009 23:00:00 +0100

Fetal Therapy 1986;1:185-192 (DOI:10.1159/000262267) (Source: Fetal Diagnosis and Therapy)

Survival of Transfused Adult Cells in the Fetus

Fetal Diagnosis and Therapy — Thu, 19 Nov 2009 23:00:00 +0100

Fetal Therapy 1986;1:193-195 (DOI:10.1159/000262268) (Source: Fetal Diagnosis and Therapy)

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In utero Bladder Diversion -- Problems with Patient Selection

Fetal Diagnosis and Therapy — Thu, 19 Nov 2009 23:00:00 +0100

Fetal Therapy 1986;1:196-202 (DOI:10.1159/000262269) (Source: Fetal Diagnosis and Therapy)

Fetal Hydrothorax in the Second Trimester of Pregnancy: Successful Intra-Uterine Treatment at 24 Weeks Gestation

Fetal Diagnosis and Therapy — Thu, 19 Nov 2009 23:00:00 +0100

Fetal Therapy 1986;1:203-209 (DOI:10.1159/000262270) (Source: Fetal Diagnosis and Therapy)

Prenatal Diagnosis and Outcome of Congenital Complete Heart Block: The Role of Fetal Echocardiography

Fetal Diagnosis and Therapy — Thu, 19 Nov 2009 23:00:00 +0100

Fetal Therapy 1986;1:210-216 (DOI:10.1159/000262271) (Source: Fetal Diagnosis and Therapy)

Bioethical Issues in Perinatology -- Is the Future Now?

Fetal Diagnosis and Therapy — Thu, 19 Nov 2009 23:00:00 +0100

Fetal Therapy 1986;1:217-222 (DOI:10.1159/000262272) (Source: Fetal Diagnosis and Therapy)

Erratum

Fetal Diagnosis and Therapy — Thu, 19 Nov 2009 23:00:00 +0100

Fetal Therapy 1986;1:222 (DOI:10.1159/000262273) (Source: Fetal Diagnosis and Therapy)

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Author Index

Fetal Diagnosis and Therapy — Thu, 19 Nov 2009 23:00:00 +0100

Fetal Therapy 1986;1:223 (DOI:10.1159/000262274) (Source: Fetal Diagnosis and Therapy)

Subject Index

Fetal Diagnosis and Therapy — Thu, 19 Nov 2009 23:00:00 +0100

Fetal Therapy 1986;1:224-226 (DOI:10.1159/000262275) (Source: Fetal Diagnosis and Therapy)

Ambivalence toward undergoing invasive prenatal testing: an exploration of its origins

Prenatal Diagnosis — Thu, 19 Nov 2009 00:00:00 +0100

This study explores ambivalence toward undergoing amniocentesis among pregnant women with overall positive attitudes. Its novelty lies in the characterization of the type and origins of the ambivalence.Thirty-six women between 35 and 44 years of age were recruited from a US prenatal testing center to participate in structured telephone interviews.Thirty women chose to undergo testing. Attitudes toward undergoing amniocentesis were generally positive, although all participants simultaneously described feeling ambivalent. The women desired the information that amniocentesis could provide yet did not want to place their fetus at risk. Participants cited religious, moral, ethical and intellectual values important in shaping their attitudes toward undergoing amniocentesis. Important referents s...

Contribution of MRI to Detect Further Anomalies in Fetal Ventriculomegaly

Fetal Diagnosis and Therapy — Wed, 18 Nov 2009 23:00:00 +0100

Fetal Diagn Ther (DOI:10.1159/000260389) (Source: Fetal Diagnosis and Therapy)

Review of perinatal management of arthrogryposis at a large UK teaching hospital serving a multiethnic population

Prenatal Diagnosis — Wed, 18 Nov 2009 00:00:00 +0100

To review the prevalence and perinatal management of cases of arthrogryposis delivering at our hospital over a 6-year period.This was a retrospective review of cases of arthrogryposis managed at a UK teaching hospital. Cases were identified from the regional congenital anomalies register and departmental databases. Case notes were reviewed and analysed.From 2002 to 2007, there were 27 cases of arthrogryposis. Sixteen (59.3%) were Caucasians, 7(25.9%) Asians and 4(14.8%) Afro-Caribbean; 17(63%) were nulliparous. In eight (29.6%) cases, there was a family history of congenital anomalies. Three had previously affected siblings and in three cases the parents were affected with arthrogryposis. Five (18.5%) were from consanguineous families. Eighteen (66.7%) cases were diagnosed prenatally at a ...

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Inter-laboratory control data for reproductive endpoints required in the OPPTS 870.3800/OECD 416 reproduction and fertility test

Birth Defects Research Part B: Developmental and Reproductive Toxicology — Tue, 17 Nov 2009 00:00:00 +0100

CONCLUSIONS: These inter-laboratory control data provide a means for laboratories to review their performance on reproductive toxicity measures, and provide perspective for interpreting their own control data and data from treated animals. Birth Defects Res (Part B), 2009. © 2009 Wiley-Liss, Inc. (Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology)

Is chorionic villus sampling associated with hypertensive disorders of pregnancy?

Prenatal Diagnosis — Tue, 17 Nov 2009 00:00:00 +0100

Our objective is to evaluate for potential associations between chorionic villus sampling (CVS) and hypertensive disorders of pregnancy.Using our genetic database, we compared the rates of hypertensive disorders between women who underwent CVS at 10-13 and 6/7 weeks with those seen for other indications at similar gestational ages who had no invasive procedure. Only singleton and euploid pregnancies were included. Statistical methods including univariable and multivariable logistic regression, supplemented by stratified analyses were used for comparisons.Among 11 012 pregnant women seen between 1990 and 2006 in our center and meeting the inclusion criteria, information on hypertensive disorders of pregnancy were available in 9386, and 9098 met the inclusion criteria. The overall incidence ...

Maternal Plasma Fibronectin and Advanced Oxidative Protein Products for the Prediction of Preeclampsia in High Risk Pregnancies: A Prospective Cohort Study

Fetal Diagnosis and Therapy — Mon, 16 Nov 2009 23:00:00 +0100

Fetal Diagn Ther (DOI:10.1159/000259317) (Source: Fetal Diagnosis and Therapy)

Newborn and Infant Nursing Reviews — Mon, 16 Nov 2009 16:19:33 +0100

(Source: Newborn and Infant Nursing Reviews)

Editorial Board

Newborn and Infant Nursing Reviews — Mon, 16 Nov 2009 16:19:33 +0100

(Source: Newborn and Infant Nursing Reviews)

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Transport of the Neonatal Patient With Persistent Pulmonary Hypertension

Newborn and Infant Nursing Reviews — Mon, 16 Nov 2009 16:19:33 +0100

This article will review the pathophysiology, assessment, diagnosis, and treatment options for a newborn with persistent pulmonary hypertension of the newborn, and considerations for infant transport to a higher level of care will be emphasized. (Source: Newborn and Infant Nursing Reviews)

Neonatal Transport – A Family Support Module

Newborn and Infant Nursing Reviews — Mon, 16 Nov 2009 16:19:33 +0100

This article describes a collaborative effort between hospital staff, outside organizations (especially the March of Dimes), community businesses and neonatal graduate families that resulted in the creation of a family support module for neonatal transport. This family support module is comprised of services and resources that can be customized to meet the needs of the regional population served. The idea that all staff at the referring hospital and regional center must be knowledgeable of the information and services being provided to families is discussed. In addition, the need for regular evaluation of materials/programs to insure effectiveness is stressed. (Source: Newborn and Infant Nursing Reviews)

The Impact of Air Ambulance Transport on Neonatal Outcomes

Newborn and Infant Nursing Reviews — Mon, 16 Nov 2009 16:19:33 +0100

Many referring facilities and transport teams function under the assumption that faster is better. However, data on the benefits of air ambulance (AA) use in neonatal transport are sparse. At our referral hospital in northwest Ohio, we compared the total time from telephone request for transport to arrival in the referral nursery by ground ambulance vs AA for each of our referring facilities and evaluated if this had an impact on patient outcomes. Time from transport call to arrival at the referring hospital was 72 ± 17 minutes by AA and 95 ± 23 minutes by ground ambulance. We demonstrated that although it was approximately 25% faster to fly to a referring hospital compared with traveling by ground, the time saved had no impact on outcome. On the basis of these data, we continue to encou...

High-Fidelity Simulation for Transport Team Training and Competency Evaluation

Newborn and Infant Nursing Reviews — Mon, 16 Nov 2009 16:19:33 +0100

Neonatal transport teams are challenged to provide high-quality, cost-effective care. Staff unpreparedness and improperly applied neonatal skills and interventions can be associated with an immeasurable increase in adverse outcomes, including pain and suffering, morbidity, mortality, and increased cost. Although historically there has been little consistency in neonatal transport team composition, training, or competency evaluation, this article will demonstrate how the utilization of simulation-based training and competency is beneficial in assuring team members receive and maintain the skills needed to recognize and manage adverse events during transport. Transport simulation standards will be proposed, and suggestions for using both low-fidelity and high-fidelity simulation are provided...

Maturation of the Cardiac Response to Sound in High-Risk Preterm Infants

Newborn and Infant Nursing Reviews — Mon, 16 Nov 2009 16:19:33 +0100

Abstract: Noise is considered a potential source of stress in the neonatal intensive care unit (NICU); yet, it is unknown how preterm infants habituate to sound in the NICU. Heart rate responses to sound were evaluated in 12 preterm infants from 32 weeks' gestational age through hospital discharge. Heart rate response changes to auditory stimuli were recorded for 10 habituation and 10 dishabituation trials. Significant heart rate deceleration began to appear by 34 weeks postconceptional age. With weeks 32 to 38 combined, a significant response was noted for the novel response. Responses differed significantly for weeks 34, 35, and 36. Infants at 36 weeks had a significant heart rate response at T17 to T20, suggesting anticipation of a third stimulus. Infants with higher Apgar 5 scores had ...

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Obstacles in Providing Neonatal Care in Kurdistan, Iraq

Newborn and Infant Nursing Reviews — Mon, 16 Nov 2009 16:19:32 +0100

This article focuses on Iraq. Newborn and infant health issues are global ones. A different area of the globe will be featured to review issues occurring in different areas of the world, which addresses Newborn and Infant Nursing Review's theme-oriented topic. This month, Iraq will be featured. Our guest authors are Drs Atiya Mohammed and Evelyn Acheson. Dr Mohammed teaches maternity nursing at Sulaimani University in Northern Iraq. Dr Acheson is the assistant professor and director of the International Health Program at the University of Oklahoma College of Nursing, Tulsa, OK. This month's article focuses on obstacles to neonatal care and neonatal transport. (Source: Newborn and Infant Nursing Reviews)

Neonatal Transport: The Family Perspective

Newborn and Infant Nursing Reviews — Mon, 16 Nov 2009 16:19:32 +0100

Neonatal transport has evolved over several decades into a highly technical and well-orchestrated event coordinated by several members of the health care team. Although there is still much to be done, advances such as the S.T.A.B.L.E. Program and the new Neonatal Pediatric Transport Certification offered by the National Certification Corporation have aided in standardization and improving competencies. The transport of an infant—be it by air or ground, planned or emergent, can be a tense time for both health care providers and family members. It is not surprising to note that in a review of the literature conducted by Steeper, most parents viewed the transport of their infant as a negative experience. This column will primarily focus on how health care providers can work together to impr...

Neonatal Transport Crossword: (Multiple word answers include spaces between words)

Newborn and Infant Nursing Reviews — Mon, 16 Nov 2009 16:19:32 +0100

(Source: Newborn and Infant Nursing Reviews)

News Flash

Newborn and Infant Nursing Reviews — Mon, 16 Nov 2009 16:19:32 +0100

(Source: Newborn and Infant Nursing Reviews)

Guest Editorial

Newborn and Infant Nursing Reviews — Mon, 16 Nov 2009 16:19:32 +0100

I am thrilled to have been given the opportunity to serve as the guest editor for this edition of Newborn and Infant Nursing Reviews. The idea for focusing on neonatal transport stems from my own professional experiences. Most of my neonatal career has occurred within a children's hospital in which no birthing facility has been attached. Therefore, I have seen many infants admitted to the neonatal intensive care unit by way of transport. (Source: Newborn and Infant Nursing Reviews)

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Editorial

Newborn and Infant Nursing Reviews — Mon, 16 Nov 2009 16:19:32 +0100

The American Academy of Pediatrics and the American College of Obstetricians and Gynecologists have guidelines for perinatal care in which they recommend that hospital-based services be organized within geographic regions to provide optimal access to expertise and experience. According to these guidelines, very-low-birth-weight (VLBW; (Source: Newborn and Infant Nursing Reviews)

Erratum

Seminars in Perinatology — Mon, 16 Nov 2009 16:19:32 +0100

The author listing for the article, “Neurodevelopmental changes of fetal pain,” which was published in Seminars in Perinatology in 2007 (31[5]:275-82), was incomplete. Dr. Barbara Clancy contributed to the article and should have been listed as an author. (Source: Seminars in Perinatology)

Ethics and “Cesarean Delivery on Maternal Demand”

Seminars in Perinatology — Mon, 16 Nov 2009 16:19:32 +0100

There is considerable ongoing debate about whether physicians should supply cesarean delivery to patients purely on the basis of maternal demand. This debate is marred by serious definitional problems. Although planned elective cesareans share a risk-profile with “cesarean delivery on maternal demand,” not every case of planned elective cesarean results from maternal demand. Ethical and practical considerations counsel using language that is more neutral on the question of the reason for, and process of decision-making leading to, cesarean delivery. Consideration of the risks and benefits of planned elective cesarean, coupled with the desirability of a prophylactic rule limiting physicians' offers of elective cesareans, counsels against making routine offers of elective cesareans to pa...

Ethics Education in Neonatal-Perinatal Medicine in the United States

Seminars in Perinatology — Mon, 16 Nov 2009 16:19:31 +0100

Neonatology is one of the specialties that has immensely benefited from advances in medical technology in the last few decades. These advances have paralleled the rise of the civil rights movements and wider recognition of individual rights. As a result, ethical decision-making has become more complex, involving patients, parents, members of the health care team, and society in general. This has created a need for formal ethics education in neonatal-perinatal medicine fellowship programs. In this article, we briefly explore the current published data on ethics education in pediatric residency and neonatal-perinatal medicine fellowship programs. Then, we discuss the questions an academic educator may face while developing an ethics curriculum in his/her medical institution. Finally, we pres...

Ethics of Research in Perinatal Medicine

Seminars in Perinatology — Mon, 16 Nov 2009 16:19:31 +0100

Ethics is an essential component of fetal research. From definitions of medical ethics and the ethical principles of beneficence and respect for autonomy, we identify the ethical concept of the fetus as a patient. We then identify major components of research ethics. On these 2 bases, we identify ethically justified criteria for initiating study of innovative fetal interventions, for randomized trials in fetal research, for making the clinical, scientific, and ethical judgment that fetal research has produced a new standard of care, and for stopping rules for fetal research. (Source: Seminars in Perinatology)

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The Texas Advance Directives Act—Is It a Good Model?

Seminars in Perinatology — Mon, 16 Nov 2009 16:19:31 +0100

The Texas Advance Directives Act was first passed in 1999 to help resolve conflicts between families and physicians when disagreements exist over continuing or halting treatments of patients. When the physician feels that continued treatment is ethically or morally unjustified and seeks to end life support for a patient against the wishes of the family, it establishes a specific path that must be followed to afford legal protection to the physician and institution. Its proponents believe that it reduces morally unjustifiable treatment of terminal patients, while its opponents argue that it places too much power in the hands of physicians and institutions. This review analyzes both sides of the argument, gives 2 examples of its application, and concludes that it is a good model but requires...

Neonatal Euthanasia

Seminars in Perinatology — Mon, 16 Nov 2009 16:19:31 +0100

Despite advances in the care of infants, there remain many newborns whose medical conditions are incompatible with sustained life. At times, healthcare providers and parents may agree that prolonging life is not an appropriate goal of care, and they may redirect treatment to alleviate suffering. While pediatric palliative treatment protocols are gaining greater acceptance, there remain some children whose suffering is unrelenting despite maximal efforts. Due to the realization that some infants suffer unbearably (ie, the burdens of suffering outweigh the benefits of life), the Dutch have developed a protocol for euthanizing these newborns. In this review, I examine the ethical aspects of 6 forms of end of life care, explain the ethical arguments in support of euthanasia, review the history...

Disputes Over Moral Standards Guiding Treatments for Imperiled Infants

Seminars in Perinatology — Mon, 16 Nov 2009 16:19:31 +0100

Two incompatible policies govern medical decision-making for infants aged < 1 year in the United States. One is the Best Interests Standard, which is the older policy, and the other is the Child Abuse Prevention and Treatment Act amendments widely known as the “Baby Doe” rules. The debate over which policy to adopt, however, is more far-reaching than treatment for one group in one country as it involves how to rank important medical values when they come into conflict. These are the values of prolonging biological life and of providing comfort and relief from pain and suffering for imperiled and incompetent persons. For reasons of justice and compassion, the Best Interests Standard is superior to Child Abuse Prevention and Treatment Act's Baby Doe Rules for guiding decision for infants...

Ethical Issues in Research Involving Infants

Seminars in Perinatology — Mon, 16 Nov 2009 16:19:31 +0100

The future health of infants and children is dependent on the performance of clinical research in which infants participate. Achieving a proper balance between this social good and the obligation to protect infants who participate in research is a significant challenge. As investigators design and implement research protocols, they should be aware of the ethical and legal requirements that govern research with infants. For research to satisfy ethical and legal requirements it must be scientifically sound and significant, subject selection must be fair, approaching families for enrollment must avoid pressure, the risks to participants cannot be excessive and must be minimized, risks must be justified by the benefits of the research, valid and voluntary informed consent must be obtained, enr...

The Ethics of Newborn Resuscitation

Seminars in Perinatology — Mon, 16 Nov 2009 16:19:31 +0100

It is widely believed in neonatology and obstetrics that there are situations in which it is inappropriate to attempt newborn resuscitation, and other times when newborn resuscitation is obligatory despite parental refusal. In each case, an ethical justification for the decision needs to be identified. This essay is intended to provide guidance in deciding when resuscitation should be attempted, and in identifying ethical considerations that should be taken into account. It specifically addresses the issue of extreme prematurity, including an analysis of current recommendations, the data, relevant rights of patient and parents, and a discussion of the relative merits of withholding resuscitation vs providing resuscitation and possibly withdrawing intensive care later. In addition to extrem...

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Introduction: Taking the Time for Medical Ethics

Seminars in Perinatology — Mon, 16 Nov 2009 16:19:31 +0100

In considering our approach to ethical problems in medicine, a good place to start is our approach to other decisions in this same arena. Most decisions that we face in the clinical setting are addressed based on some combination of personal experience, education, professional guidelines, standard of care, understanding of physiology, and scientific evidence. The ongoing emphasis on evidence-based medicine, however, rightly suggests that these factors should not be given equal weight. That is, good clinical trials should count for more than personal opinion, or how one was trained years ago. Moreover, if there is a clinical approach widely or even universally accepted within the profession that is clearly inconsistent with good data, the approach should be re-examined, and should likely be...

Seminars in Perinatology — Mon, 16 Nov 2009 16:19:31 +0100

(Source: Seminars in Perinatology)

Topics for 2008

Seminars in Perinatology — Mon, 16 Nov 2009 16:19:31 +0100

(Source: Seminars in Perinatology)

Masthead

Seminars in Perinatology — Mon, 16 Nov 2009 16:19:31 +0100

(Source: Seminars in Perinatology)

Cover

Seminars in Perinatology — Mon, 16 Nov 2009 16:19:31 +0100

(Source: Seminars in Perinatology)

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Dietary selenium plus folic acid as an antioxidant therapy for ethanol-exposed pups

Birth Defects Research Part B: Developmental and Reproductive Toxicology — Mon, 16 Nov 2009 00:00:00 +0100

CONCLUSIONS: These results suggest that folic acid+Se could be effective in neutralising the damage of ethanol consumption in pups since it prevents peroxidation protein products. Birth Defects Res (Part B), 2009. © 2009 Wiley-Liss, Inc. (Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology)

Influence of maternal BMI on genetic sonography in the FaSTER trial

Prenatal Diagnosis — Mon, 16 Nov 2009 00:00:00 +0100

We sought to evaluate the influence of maternal body mass index (BMI) on sonographic detection employing data from the FaSTER trial.Unselected singleton pregnancies underwent detailed genetic sonogram to evaluate for structural fetal anomalies and soft markers for aneuploidy. BMI (kg/m2) were calculated from reported initial visit values. Sensitivity, specificity, false positive and false negative rates (FPR and FNR), likelihood ratio, detection rates, and a missed diagnosis rate (MDR: FNR + marker recorded as 'missing'/N) were calculated.Eight thousand five hundred and fifty-five patients with complete BMI information had detailed genetic sonography. A lower sensitivity with an elevated FNR and MDR was observed in obese women for multiple aneuploid markers (e.g. [ge]2 markers 32% sensitiv...

Endoscopic laser coagulation following amnioreduction for the management of a large placental chorioangioma

Prenatal Diagnosis — Mon, 16 Nov 2009 00:00:00 +0100

No Abstract. (Source: Prenatal Diagnosis)

Assessing the role of placental trisomy in preeclampsia and intrauterine growth restriction

Prenatal Diagnosis — Mon, 16 Nov 2009 00:00:00 +0100

Prenatally diagnosed confined placental trisomy is associated with increased risk for intrauterine growth restriction (IUGR) and preeclampsia. However, it is unclear how often this might underlie pregnancy complications. Our objective was to evaluate the frequency and distribution of trisomic cells in placentae ascertained for IUGR and/or preeclampsia.Comparative genomic hybridization was applied to two uncultured biopsies from each of 61 placentae referred with maternal preeclampsia and/or IUGR, 11 cases with elevated maternal serum hCG and/or AFP but no IUGR or preeclampsia, and 85 control placentae.Trisomy was observed in four placentae among the IUGR group (N = 43) but in no case of preeclampsia in the absence of IUGR (N = 18). Trisomy was observed in 1 of the 11 cases ascertained for ...

Contemporary neonatal intensive care management in congenital diaphragmatic hernia: does this obviate the need for fetal therapy?

Fetal and Maternal Medicine Review — Fri, 13 Nov 2009 16:07:54 +0100

Research ArticlesDESMOND BOHN, Fetal and Maternal Medicine Review, Volume 20 Issue 04 , pp 319-339Abstract (Source: Fetal and Maternal Medicine Review)

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Determination of individual preference: why, how and alternatives

Fetal and Maternal Medicine Review — Fri, 13 Nov 2009 16:07:54 +0100

Research ArticlesDALJIT SAHOTA, TAK YEUNG LEUNG, TZE KIN LAU, Fetal and Maternal Medicine Review, Volume 20 Issue 04 , pp 301-317Abstract (Source: Fetal and Maternal Medicine Review)

Rho proteins, pregnancy and labour

Fetal and Maternal Medicine Review — Fri, 13 Nov 2009 16:07:54 +0100

Research ArticlesJ LARTEY, A LÓPEZ BERNAL, Fetal and Maternal Medicine Review, Volume 20 Issue 04 , pp 283-299Abstract (Source: Fetal and Maternal Medicine Review)

Diagnosis and management of selective fetal growth restriction in monochorionic twins

Fetal and Maternal Medicine Review — Fri, 13 Nov 2009 16:07:54 +0100

Research ArticlesEDUARD GRATACÓS, ELISENDA EIXARCH, FATIMA CRISPI, Fetal and Maternal Medicine Review, Volume 20 Issue 04 , pp 269-281Abstract (Source: Fetal and Maternal Medicine Review)

FMR volume 20 issue 4 Cover and Back matter

Fetal and Maternal Medicine Review — Fri, 13 Nov 2009 16:07:54 +0100

Miscellaneous Fetal and Maternal Medicine Review, Volume 20 Issue 04 , pp b1-b10Abstract (Source: Fetal and Maternal Medicine Review)

FMR volume 20 issue 4 Cover and Front matter

Fetal and Maternal Medicine Review — Fri, 13 Nov 2009 16:07:54 +0100

Miscellaneous Fetal and Maternal Medicine Review, Volume 20 Issue 04 , pp f1-f2Abstract (Source: Fetal and Maternal Medicine Review)

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Acknowledgement

Journal of Perinatal Medicine — Fri, 13 Nov 2009 16:07:31 +0100

Journal of Perinatal Medicine 37 (6): XII-XIII No abstract available (Source: Journal of Perinatal Medicine)

Index - Authors

Journal of Perinatal Medicine — Fri, 13 Nov 2009 16:07:31 +0100

Journal of Perinatal Medicine 37 (6): IX-XI No abstract available (Source: Journal of Perinatal Medicine)

Index - Subjects

Journal of Perinatal Medicine — Fri, 13 Nov 2009 16:07:31 +0100

Journal of Perinatal Medicine 37 (6): VI-VIII No abstract available (Source: Journal of Perinatal Medicine)

Index Volume 37 (2009) - Contents

Journal of Perinatal Medicine — Fri, 13 Nov 2009 16:07:31 +0100

Journal of Perinatal Medicine 37 (6): I-V No abstract available (Source: Journal of Perinatal Medicine)

Congress Calendar

Journal of Perinatal Medicine — Fri, 13 Nov 2009 16:07:31 +0100

Journal of Perinatal Medicine 37 (6): 726-726 No Abstract available (Source: Journal of Perinatal Medicine)

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Emile Papiernik will stay alive in our thoughts

Journal of Perinatal Medicine — Fri, 13 Nov 2009 16:07:31 +0100

Journal of Perinatal Medicine 37 (6): 723-725 No abstract available (Source: Journal of Perinatal Medicine)

Breast feeding as human and divine nourishment

Journal of Perinatal Medicine — Fri, 13 Nov 2009 16:07:31 +0100

Journal of Perinatal Medicine 37 (6): 721-721 No abstract available (Source: Journal of Perinatal Medicine)

Congenital cataract with de novo balanced reciprocal t(3;13) (q23;q12) translocation in a newborn

Journal of Perinatal Medicine — Fri, 13 Nov 2009 16:07:31 +0100

Journal of Perinatal Medicine 37 (6): 717-719 No abstract available (Source: Journal of Perinatal Medicine)

Vanishing nuchal translucency syndrome

Journal of Perinatal Medicine — Fri, 13 Nov 2009 16:07:31 +0100

Journal of Perinatal Medicine 37 (6): 715-716 No abstract available (Source: Journal of Perinatal Medicine)

Diagnosis and treatment of maternal acute myeloid leukemia during pregnancy imitating HELLP syndrome

Journal of Perinatal Medicine — Fri, 13 Nov 2009 16:07:31 +0100

Journal of Perinatal Medicine 37 (6): 713-714 No abstract available (Source: Journal of Perinatal Medicine)

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Obstetric outcomes of low-risk labors at ‘Japanese tatami’ mat delivery room: a preliminary study

Journal of Perinatal Medicine — Fri, 13 Nov 2009 16:07:31 +0100

Conclusions: We found no evidence that the Japanese room is unsafe for low-risk infants and mothers in comparison with the standard Western-style delivery room. (Source: Journal of Perinatal Medicine)

Serum proinflammatory cytokine – interleukin-8 as possible infection site marker in preterm deliveries

Journal of Perinatal Medicine — Fri, 13 Nov 2009 16:07:31 +0100

Conclusions: The results indicate that serum level of interleukin-8 might be used as non-invasive marker of infections in pregnancy, as well as a marker of preterm deliveries. (Source: Journal of Perinatal Medicine)

Early enteral feeding in conservatively managed stage II necrotizing enterocolitis is associated with a reduced risk of catheter-related sepsis

Journal of Perinatal Medicine — Fri, 13 Nov 2009 16:07:31 +0100

Conclusion: Shorter fasting after NEC appears to lower morbidity after the acute phase of the disease. In particular, shorter-fasted neonates have significantly less catheter-related sepsis. We found no benefit in longer fasting. (Source: Journal of Perinatal Medicine)

The clinical outcomes of late preterm infants: a multi-center survey of Zhejiang, China

Journal of Perinatal Medicine — Fri, 13 Nov 2009 16:07:31 +0100

Conclusions: Late preterm infants are associated with very high cesarean section rate and have more medical problems and poorer short-term outcomes than term infants in China. (Source: Journal of Perinatal Medicine)

Reduction of IGF-binding protein-3 as a potential marker of intra-uterine growth restriction

Journal of Perinatal Medicine — Fri, 13 Nov 2009 16:07:31 +0100

Journal of Perinatal Medicine 37 (6): 689-693 Abstract Background: Growth factor-binding proteins influence the growth of infants starting in utero. Adaptation of the fetus to an adverse uterine environment is associated with changes in the growth hormone-growth factor-insulin axis. Aims: To evaluate serum levels of IGF-I and IGFBP-3 in small and appropriate for gestational age newborn infants. Methods: Fifty-four newborn infants, small (SGA, n=28) or appropriate (AGA, n=26) for gestational age were matched by gestational age and sex. Blood was collected on the first day of life, and anthropometric measurements were taken at birth. The serum levels of IGF-I and IGFBP-3 were compared, and correlated with the anthropometric measurements. Results: On the first day of life, mean serum IGFBP-3 ...

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Disparity in circulating adiponectin multimers between term and preterm infants

Journal of Perinatal Medicine — Fri, 13 Nov 2009 16:07:31 +0100

Journal of Perinatal Medicine 37 (6): 683-688 Abstract Aims: To study circulating levels and distribution of adiponectin multimers [low molecular weight (LMW)-, medium molecular weight (MMW)- and high molecular weight (HMW)-adiponectin] in preterm and full-term infants. Methods: Total serum adiponectin and its multimers were measured in 40 healthy infants at the age of one month and associations with anthropometric parameters [body weight and length, body mass index (BMI)], weight gain and metabolic indices (glucose, insulin) were examined. Twenty of the infants were born preterm (gestational age 33.2±1.6 weeks). Results: LMW-adiponectin level and its fractional ratio to total adiponectin were significantly higher in full-term than in preterm infants (P (Source: Journal of Perinatal Medi...

Indicators of compliance for developmental follow-up of infants discharged from a regional NICU

Journal of Perinatal Medicine — Fri, 13 Nov 2009 16:07:31 +0100

Conclusions: Several factors associated with compliance have been identified. Direct patient contact after discharge positively correlated with improved follow-up attendance. The severity of patient disease in the NICU did not impact follow-up rates. As a result close attention needs to be paid to factors which influence compliance with outpatient follow-up for developmental screening. (Source: Journal of Perinatal Medicine)

Nuchal translucency and lymphatic system maldevelopment

Journal of Perinatal Medicine — Fri, 13 Nov 2009 16:07:31 +0100

We describe the histological examination of 18 aborted fetuses that had increased nuchal translucency (NT) between 11+0 and 13+6 weeks' gestation. The aim of this study was to assess the corresponding NT anatomic features by immunohistochemical (IHC) investigation. A morphological study was performed using lymphatic and blood endothelial specific markers, as well as smooth muscle actin (SMA). We found that all 18 cases were D2-40 positive, CD31 positive, and CD34 negative, suggesting the presence of nuchal lymph vessel ectasia. We found that 12/18 cases were SMA staining positive and 6/18 cases were SMA negative, suggesting that 6/18 cases had nuchal cystic lymphangiectasia, whereas 12/18 had cystic hygromas. The present data seem to confirm the reasonable hypothesis that lymphangiogenesi...

A new obstetrical polyurethane versus stainless steel forceps: a comparison of forces generated to the base of the fetal skull during simulated deliveries

Journal of Perinatal Medicine — Fri, 13 Nov 2009 16:07:31 +0100

Conclusion: The polyurethane forceps applied 50% less overall mechanical force than the steel forceps at the tip of the forceps and base of the skull during simulated occiput anterior outlet deliveries. (Source: Journal of Perinatal Medicine)

Utility of two-dimensional echocardiography in pregnancy and post-partum period and impact on management in an inner city hospital

Journal of Perinatal Medicine — Fri, 13 Nov 2009 16:07:31 +0100

Conclusions: Although the ACCF appropriateness criteria have not been specifically studied in pregnancy, our study demonstrates that the criteria are applicable if used appropriately in pregnancy. Most indications in our study correlated with the appropriateness criteria. Although most findings were normal, information from echocardiograms impacted on management in the majority of patients, contributing to therapeutic decision-making. The reliability of echocardiograms performed according to appropriate criteria to assist clinical decisions was excellent even in patients with physiologic cardiovascular changes. (Source: Journal of Perinatal Medicine)

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Decreased placental oxygenation capacity in pre-eclampsia: clinical application of a novel index of placental function preformed at the time of delivery

Journal of Perinatal Medicine — Fri, 13 Nov 2009 16:07:31 +0100

Journal of Perinatal Medicine 37 (6): 657-661 Abstract Objective: We have previously described placental oxygenation capacity as an index of placental function. The aim of this study was to utilize this test to evaluate placental gas exchange capacity in pre-eclampsia and fetal growth restriction (FGR). Study design: Two nested case-control studies were conducted between: (i) pre-eclamptic appropriate-for-gestational-age fetus (AGA) and non-pre-eclamptic AGA; and (ii) pre-eclamptic FGR and non-pre-eclamptic FGR based on gestational age match. Umbilical A-V gas differences were compared between groups. Results: Pre-eclamptic AGA was associated with smaller A-V pO2 and A-V pCO2 differences compared to non-pre-eclampsia (A-V pO2, 7.1±3.8 mm Hg vs. 11.3±5.9 mm Hg, P=0.001; A-V pCO2, 7.8±5...

The effect of maternal obesity on the course of labor

Journal of Perinatal Medicine — Fri, 13 Nov 2009 16:07:31 +0100

Conclusions: Maternal obesity is associated with active phase labor dysfunction, specifically arrest of dilatation. (Source: Journal of Perinatal Medicine)

Maternal serum adiponectin multimers in gestational diabetes

Journal of Perinatal Medicine — Fri, 13 Nov 2009 16:07:31 +0100

Journal of Perinatal Medicine 37 (6): 637-650 Abstract Objective: Adiponectin, an adipokine with profound insulin-sensitizing effect, consists of heterogeneous species of multimers. These oligomeric complexes circulate as low-molecular-weight (LMW) trimers, medium-molecular-weight (MMW) hexamers and high-molecular-weight (HMW) isoforms and can exert differential biological effects. The aims of this study were to determine whether there is a change in circulating adiponectin multimers in the presence of gestational diabetes mellitus (GDM), overweight/obesity or with a treatment with sulfonylurea or insulin in patients with GDM. Study design: This cross-sectional study included women with: 1) normal pregnancy (n=149); and 2) patients with GDM (n=72). Thirty-three patients with GDM were manag...

Maternal serum adiponectin multimers in patients with a small-for-gestational-age newborn

Journal of Perinatal Medicine — Fri, 13 Nov 2009 16:07:31 +0100

Journal of Perinatal Medicine 37 (6): 623-635 Abstract Objective: Several mechanisms of disease have been implicated in the pathophysiology of small-for-gestational-age (SGA) including an anti-angiogenic state, and an exaggerated intravascular pro-inflammatory response. Adiponectin plays a role in a wide range of biological activities including those that have been implicated in the pathophysiology SGA. Thus, the aim of this study was to determine if third trimester adiponectin concentrations differed between women with normal weight infants and those with an SGA neonate. Study design: This cross-sectional study included women with: 1) a normal pregnancy (n=234); and 2) an SGA neonate (n=78). SGA was defined as a birth weight below the 10th percentile for gestational age at birth. The stud...

Risk assessment for preeclampsia in women with gestational diabetes mellitus

Journal of Perinatal Medicine — Fri, 13 Nov 2009 16:07:31 +0100

Journal of Perinatal Medicine 37 (6): 617-621 Abstract Aim: To develop a clinical model to assess the risk of preeclampsia in women with gestational diabetes mellitus (GDM). Methods: We studied clinical characteristics of 813 consecutive women who had GDM between January 2003 and February 2008 at our institution. The clinical features which were significantly associated with preeclampsia by multiple logistic regression analysis were integrated into a risk model. The diagnostic performance of this model was then evaluated from a receiver-operating characteristic (ROC) curve analysis. Results: A total of 78 women with GDM (9.6%) developed preeclampsia. In a multivariable analysis, first-trimester BMI ≥27 kg/m2 (P (Source: Journal of Perinatal Medicine)

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Gene expression profiling of maternal blood in early onset severe preeclampsia: identification of novel biomarkers

Journal of Perinatal Medicine — Fri, 13 Nov 2009 16:07:31 +0100

Conclusions: Expression of genes with diverse function is associated with ES-PE risk, providing opportunities for the development of non-invasive diagnosis. (Source: Journal of Perinatal Medicine)

Survival and major disability rate in infant born at 22–25 weeks of gestation

Journal of Perinatal Medicine — Fri, 13 Nov 2009 16:07:31 +0100

Journal of Perinatal Medicine 37 (6): 599-608 Abstract Our aim was to evaluate the literature on survival and major disability rate in preterm infants born at 22– 25 weeks of gestational age (GA). Thirty-three studies were identified and reviewed. Survival was lower in population-based studies (2% at 22, 13% at 23, 35% at 24, and 56% at 25 weeks) than in center-based study (15% at 22, 41% at 23, 58% at 24, and 74% at 25 weeks). The severe disability rate was slightly higher in population-based studies than in center-based studies at 23 (29 vs. 32%) and at 24 (30 vs. 27%) week of GA, whereas it was similar in population and center-based studies at 25 (21 vs. 22%) weeks of GA. Survival rate seems to improve with time, whereas the change of severe disability rate cannot be adequately eva...

The infant incubator in the neonatal intensive care unit: unresolved issues and future developments

Journal of Perinatal Medicine — Fri, 13 Nov 2009 16:07:31 +0100

Journal of Perinatal Medicine 37 (6): 587-598 Abstract Since the 19th century, devices termed incubators were developed to maintain thermal stability in low birth weight (LBW) and sick newborns, thus improving their chances of survival. Remarkable progress has been made in the production of infant incubators, which are currently highly technological devices. However, they still need to be improved in many aspects. Regarding the temperature and humidity control, future incubators should minimize heat loss from the neonate and eddies around him/her. An unresolved issue is exposure to high noise levels in the Neonatal Intensive Care Unit (NICU). Strategies aimed at modifying the behavior of NICU personnel, along with structural improvements in incubator design, are required to reduce noise ex...

The complete three-vessel view in prenatal detection of congenital heart defects

Prenatal Diagnosis — Thu, 12 Nov 2009 00:00:00 +0100

To evaluate the effectiveness of the complete three-vessel view (c3VV) in assessment of fetuses with prenatally diagnosed congenital heart defects (CHD).Fetuses with prenatal suspicion of CHD were prospectively recruited into the study. All examinations included a c3VV for assessment of abnormalities in alignment, arrangement, vessel size, number of vessels, aortic arch sidedness and color flow mapping. Definite diagnoses of CHD were based on neonatal cardiologic exams or postnatal autopsy.Of 106 consecutive fetuses with CHD, 75 were shown to have at least one abnormality on the c3VV, a detection rate of 70.8%. When septal wall defects were excluded, the detection rate increased to 89%. All cases of transposition of great arteries (TGA), aortic stenosis, pulmonary stenosis, truncus arterio...

Prenatal diagnosis of platyspondylic skeletal dysplasia Torrance type with three-dimensional helical computed tomography

Prenatal Diagnosis — Thu, 12 Nov 2009 00:00:00 +0100

No Abstract. (Source: Prenatal Diagnosis)

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First trimester maternal serum pregnancy-specific beta-1-glycoprotein (SP1) as a marker of adverse pregnancy outcome

Prenatal Diagnosis — Thu, 12 Nov 2009 00:00:00 +0100

To establish the first trimester levels of pregnancy-specific beta-1-glycoprotein (SP1) in pregnancies with adverse outcome. Furthermore, to determine the screening performance for adverse outcome using SP1 alone and in combination with other first trimester markers including proMBP and PAPP-A.A case-control study was conducted in a primary hospital setting. The SP1 concentration was measured in first trimester maternal serum in pregnancies with small-for-gestational age fetuses (SGA) (n = 150), spontaneous preterm delivery (n = 88), preeclampsia (n = 40) and in controls (n = 500). Concentrations were converted to multiples of the median (MoM) in controls and groups were compared using Mann-Whitney U-test. Logistic regression analysis was used to determine significant factors for predictin...

The maternal age-specific live birth prevalence of trisomies 13 and 18 compared to trisomy 21 (Down syndrome)

Prenatal Diagnosis — Thu, 12 Nov 2009 00:00:00 +0100

Hyperechoic congenital lung lesions in a non-selected population: from prenatal detection till perinatal management

Prenatal Diagnosis — Thu, 12 Nov 2009 00:00:00 +0100

To present longitudinal observations of hyperechoic lung lesions (HLL) in a non-selected population from the time of prenatal diagnosis by ultrasound (US) until postnatal surgery.We conducted a retrospective study of all fetuses diagnosed with an HLL between 1990 and 2005 in our Fetal Medicine Unit.We observed 21 cases of HLL. Among the 17 fetuses with unilateral lesion, two cyst punctures were attempted on fetuses with signs of fetal compromise. Termination of pregnancy (TOP) was performed on seven fetuses. Fourteen fetuses were followed till birth. First Chest X-ray was abnormal in ten cases, while delayed CT scans revealed a lung lesion in 12 cases. Two neonates required emergency surgery and died post operatively. Surgery was successfully performed in all other cases (n = 10). Patholog...

False-positive prenatal diagnosis of trisomy 18 by interphase FISH: hybridization of chromosome 18 alpha-satellite probe (D18Z1) to chromosome 2

Prenatal Diagnosis — Thu, 12 Nov 2009 00:00:00 +0100

No Abstract. (Source: Prenatal Diagnosis)

Prognostic Role of Uterine Artery Doppler in Patients with Preeclampsia

Fetal Diagnosis and Therapy — Tue, 10 Nov 2009 23:00:00 +0100

Fetal Diagn Ther (DOI:10.1159/000258048) (Source: Fetal Diagnosis and Therapy)

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The safety of obstetrical ultrasound: a review

Prenatal Diagnosis — Sat, 07 Nov 2009 00:00:00 +0100

This article reviews the current status of ultrasound safety within obstetrics, including proposed mechanisms of harm, existing scientific and clinical evidence regarding those mechanisms, and considerations of safety for the clinical user. Copyright © 2009 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis)

Chorioamnionitis and Intrauterine Fetal Death after Second-Trimester Amniocentesis

Fetal Diagnosis and Therapy — Wed, 04 Nov 2009 23:00:00 +0100

Fetal Diagn Ther (DOI:10.1159/000257087) (Source: Fetal Diagnosis and Therapy)

Is Routine TORCH Screening Warranted in Neonates with Lenticulostriate Vasculopathy?

Neonatology — Wed, 04 Nov 2009 00:00:00 +0100

Conclusions: Routinely applied efforts to diagnose congenital infections in cases presenting with LSV have a poor yield. Routine TORCH screening in neonates with LSV cases should only be regarded as mandatory once well-designed studies demonstrate a clear diagnostic benefit. PMID: 19887856 [PubMed - as supplied by publisher] (Source: Neonatology)

Neurally Adjusted Ventilatory Assist and Pressure Support Ventilation in Small Species and the Impact of Instrumental Dead Space.

Neonatology — Wed, 04 Nov 2009 00:00:00 +0100

Conclusion: This study demonstrates, in a small group of animals, that NAVA can deliver assist in very small species with a higher efficiency than PSV in terms of eliminating CO(2) for a given minute ventilation. PMID: 19887857 [PubMed - as supplied by publisher] (Source: Neonatology)

N-Carbamylglutamate in Emergency Management of Hyperammonemia in Neonatal Acute Onset Propionic and Methylmalonic Aciduria.

Neonatology — Wed, 04 Nov 2009 00:00:00 +0100

We report on two full-term neonates, one with propionic aciduria and the other with methylmalonic aciduria, whose plasma ammonia concentrations responded dramatically to oral N-carbamylglutamate. N-carbamylglutamate, added to the classic treatment, quickly normalized plasma ammonia levels in both patients and avoided the need of hemodialysis or peritoneal dialysis. A particularly sudden fall of ammonia was obtained in one patient through beginning N-carbamylglutamate treatment precociously. PMID: 19887858 [PubMed - as supplied by publisher] (Source: Neonatology)

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Low Leptin Concentration in the First Gestational Trimester Is Associated with Being Born Small for Gestational Age: Prospective Study in Rio de Janeiro, Brazil.

Neonatology — Wed, 04 Nov 2009 00:00:00 +0100

Conclusions: Lower leptin concentrations were associated with a significant risk for SGA after adjusting for confounding variables. Maternal serum leptin at the beginning of gestation can be used as a marker for the early detection of SGA. PMID: 19887859 [PubMed - as supplied by publisher] (Source: Neonatology)

High Faecal Calprotectin Levels in Healthy, Exclusively Breast-Fed Infants.

Neonatology — Wed, 04 Nov 2009 00:00:00 +0100

Conclusions: Our findings show that the kind of feeding influences the faecal calprotectin concentration, with higher values in healthy exclusively BF infants than in FF ones. Our study does not allow us to clearly identify the reason for our finding; this could be due to hormones (such as ghrelin and leptin), cytokines and other immunostimulating and growth factors (such as epidermal growth factor and granulocyte colony-stimulating factor) in human milk, which contribute to the development of the gastrointestinal immune system. Further investigations are needed to better clarify the mechanism underlying the relationship between feeding and faecal calprotectin levels in young infants. PMID: 19887860 [PubMed - as supplied by publisher] (Source: Neonatology)

Cord Blood Cardiac Troponin T and Nonprotein-Bound Iron Levels in Newborns of Mild Pre-Eclamptic Mothers.

Neonatology — Wed, 04 Nov 2009 00:00:00 +0100

Conclusions: Increased levels of cTnT may be a biochemical marker of cardiac involvement in babies of mild pre-eclamptic mothers. In this study, no correlation was found between cTnT levels and NPBI levels. PMID: 19887861 [PubMed - as supplied by publisher] (Source: Neonatology)

Impact of Skin to Skin Care, Prone and Supine Positioning on Cardiorespiratory Parameters and Thermoregulation in Premature Infants.

Neonatology — Wed, 04 Nov 2009 00:00:00 +0100

Conclusion: We found no significant SSC-mediated changes in quality and quantity of desaturations and in body temperature compared to PP in preterm infants. PMID: 19887862 [PubMed - as supplied by publisher] (Source: Neonatology)

Skin to Skin Care in the Neonatal Intensive Care Unit: More Data Regarding Seriously Ill Infants Are Badly Needed. Commentary on Heimann et al.: Impact of Skin to Skin Care, Prone and Supine Positioning on Cardiorespiratory Parameters and Thermoregulation in Premature Infants (Neonatology 2010;97:311-317).

Neonatology — Wed, 04 Nov 2009 00:00:00 +0100

Authors: Bohnhorst B PMID: 19887863 [PubMed - as supplied by publisher] (Source: Neonatology)

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A prospective study of maternal carboxyhaemoglobin and pre-eclampsia risk

Paediatric and Perinatal Epidemiology — Wed, 04 Nov 2009 00:00:00 +0100

Rudra CB, Williams MA, Schiff MA, Koenig JQ, Dills R, Yu J. A prospective study of maternal carboxyhaemoglobin and pre-eclampsia risk. Paediatric and Perinatal Epidemiology 2009. We aimed to measure the relationship between early-pregnancy maternal carboxyhaemoglobin and subsequent pre-eclampsia risk. A nested case[ndash]control analysis was conducted using data from a western Washington State cohort study (1996[ndash]2004). We measured maternal whole blood carboxyhaemoglobin in 128 women who developed pre-eclampsia and 419 normotensive controls (mean gestational age at blood draw, 14.8 weeks). After adjustment for confounders, high ([ge]1%) vs. low ( (Source: Paediatric and Perinatal Epidemiology)

Volume 20 Issue 04

Fetal and Maternal Medicine Review — Sun, 01 Nov 2009 00:00:00 +0100

Fetal and Maternal Medicine Review, Volume 20 Issue 04 Fetal and Maternal Medicine Review publishes high quality reviews drawn from all relevant disciplines in this rapidly expanding field. Each issue includes a selection of clinical and research reviews from experts in the field. Rapid publication and a deliberate preference for authors currently active in research ensures this journal has immediate relevance to contemporary clinical practice. Subject areas covered include fetal medicine, maternal medicine, neonatology, obstetric anaesthesia, epidemiology and basic science. It is essential reading for all engaged in the care of pregnant women and neonates including obstetricians and neonatologists, postgraduates training for specialist careers, specialist nursing and midwifery staff. (Sou...

Delivery mode for the extremely premature fetus: a statement of the prematurity working group of the World Association of Perinatal Medicine

Journal of Perinatal Medicine — Sun, 01 Nov 2009 00:00:00 +0100

This article displays the available evidence and discusses this issue, including many aspects such as the difficulty in deciding when delivery is imminent, the negative impact on maternal morbidity and mortality and the cost to society of such a policy. The available scientific evidence does not support a recommendation for cesarean delivery for improving survival or decreasing morbidity for the extremely premature fetus. (Source: Journal of Perinatal Medicine)

EDITORIAL: on Being a Professional.

Neonatal Network — Sun, 01 Nov 2009 00:00:00 +0100

Authors: Fraser D PMID: 19892632 [PubMed - in process] (Source: Neonatal Network)

Sodium valproate and the fetus: a case study and review of the literature.

Neonatal Network — Sun, 01 Nov 2009 00:00:00 +0100

We present a case that illustrates the need for better education of mothers taking valproate and the medical staff prescribing it. PMID: 19892633 [PubMed - in process] (Source: Neonatal Network)

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Recognizing craniosynostosis.

Neonatal Network — Sun, 01 Nov 2009 00:00:00 +0100

This article examines this defect and discusses its embryologic origin. A systemic physical assessment guide serves as a tool to enhance early recognition of this defect. Pictorial examples increase understanding of the defect. A discussion of treatment and nursing implications, with an emphasis on family support, is provided. PMID: 19892634 [PubMed - in process] (Source: Neonatal Network)

Human-milk feeding after NICU discharge.

Neonatal Network — Sun, 01 Nov 2009 00:00:00 +0100

This study explores the breastfeeding experiences of mothers of these at-risk infants to determine their breastfeeding patterns and to better understand reasons they prematurely stop breastfeeding and/or human-milk feeding (HMF). DESIGN: A qualitative, longitudinal, descriptive design was used. SAMPLE: The sample consisted of 144 mothers whose preterm or ill infants were cared for in either an NICU or an intermediate care nursery in a large central Canadian city; 112 mothers completed data collection to six weeks after their infants were discharged from the hospital. MAIN OUTCOME VARIABLE: The main outcome variable was continued breastfeeding or HMF of formerly ill or preterm infants at one and six weeks after their discharge from the hospital. RESULTS: Of infants who were being fed mother...

Educational interventions to reduce the rate of central catheter-related bloodstream infections in the NICU: a review of the research literature.

Neonatal Network — Sun, 01 Nov 2009 00:00:00 +0100

Authors: Semelsberger CF Catheter-related bloodstream infections (CR-BSIs) are a significant cause of morbidity and mortality in the NICU, occurring at rates ranging from 11.3 per 1,000 catheter days in infants <1,000 g to 4 per 1,000 catheter days in infants >2,500 g. Cost-effective and successful educational interventions aimed at nurses have been shown to decrease CR-BSIs with adults, but no such studies address neonatal nurses. This literature review examined how educational interventions could help neonatal nurses reduce infection rates in patients with central venous catheters. Four databases were searched: PubMed, CINAHL, Cochrane, and OVID. Of ten studies that measured CR-BSIs before and after educational interventions, nine showed a postintervention reduction in the rate...

Nursing liability and chain of command.

Neonatal Network — Sun, 01 Nov 2009 00:00:00 +0100

Authors: Smalls HT PMID: 19892639 [PubMed - in process] (Source: Neonatal Network)

Helping NICU families through the holidays.

Neonatal Network — Sun, 01 Nov 2009 00:00:00 +0100

Authors: Discenza D PMID: 19892640 [PubMed - in process] (Source: Neonatal Network)

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Little boy blue.

Neonatal Network — Sun, 01 Nov 2009 00:00:00 +0100

Authors: Gunn J PMID: 19892641 [PubMed - in process] (Source: Neonatal Network)

Findings from the national institute of nursing research related to neonatal care: 2009 update.

Neonatal Network — Sun, 01 Nov 2009 00:00:00 +0100

Authors: National Institute Of Nursing Research National Institutes Of Health Department Of Health And Human Services This annotated bibliography summarizes recent findings from studies supported by the National Institute of Nursing Research (NINR) related to a broad range of maternal and neonatal health issues. By sharing this bibliography, we at NINR hope to increase the awareness of these valuable research findings within the health care community and support the continued development of evidence-based nursing practice in antenatal, postpartum, neonatal, and family care settings. PMID: 19892642 [PubMed - in process] (Source: Neonatal Network)

Anatomy of the Circle of Willis and Blood Flow in the Brain-Feeding Vasculature in Prematurely Born Infants.

Neonatology — Fri, 30 Oct 2009 00:00:00 +0100

Conclusion: Preterm neonates show a high prevalence of variant types of the circle of Willis at term-equivalent age. A relation could be demonstrated between variations in the circle of Willis and the flow in the ICA and BA. PMID: 19887852 [PubMed - as supplied by publisher] (Source: Neonatology)

Closure Times Measured by the Platelet Function Analyzer PFA-100(R) Are Longer in Neonatal Blood Compared to Cord Blood Samples.

Neonatology — Fri, 30 Oct 2009 00:00:00 +0100

Conclusions: Platelet function in response to ADP appears to improve with advancing GA. The differences between cord blood and neonatal blood CTs indicate that substantial changes in primary hemostasis occur shortly after birth. The reasons underlying these changes are unknown. PMID: 19887853 [PubMed - as supplied by publisher] (Source: Neonatology)

Maternal-to-Infant Transmission of Probiotics: Concept Validation in Mice, Rats, and Pigs.

Neonatology — Fri, 30 Oct 2009 00:00:00 +0100

Conclusions: Probiotic bacteria administered to mothers during late gestation are transferred to infants born vaginally and influence the assemblages of GIT bacteria. However, colonization of the neonatal GIT and persistence past weaning does not occur in all offspring and varies among probiotics and animal models. PMID: 19887854 [PubMed - as supplied by publisher] (Source: Neonatology)

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Glucocorticoids Suppress Growth in Neonatal Cardiomyocytes Co-Expressing AT(2) and AT(1) Angiotensin Receptors.

Neonatology — Fri, 30 Oct 2009 00:00:00 +0100

Conclusions: The present study provides novel evidence that glucocorticoids suppress neonatal cardiomyocyte growth responsiveness when AT(2 )and AT(1) receptor subtypes are co-expressed. PMID: 19887855 [PubMed - as supplied by publisher] (Source: Neonatology)

Survey of Neonates in Pomerania (SNiP): a population-based birth study – objectives, design and population coverage

Paediatric and Perinatal Epidemiology — Fri, 30 Oct 2009 00:00:00 +0100

The objectives of SNiP are to establish (a) a population-based birth cohort providing detailed information about neonatal health, morbidity and mortality, (b) a biobank with newborn DNA and serum from cord blood, placenta tissue samples and DNA obtained from oral mucosal swabs of the mothers, (c) a prospective study design by re-examination of the SNiP population prior to attendance at primary school. From March 2003 until November 2008 all childbearing mothers in a well-defined region in North-Eastern Germany were asked to participate with their newborns. Detailed data on health status of the newborn, pregnancy, medical and family history, socio-economic status and maternal life style were obtained via face-to-face interview, standardised questionnaires and medical records. Placental tiss...

The Use of Sildenafil in Persistent Pulmonary Hypertension of the Newborn

American Journal of Perinatology — Thu, 29 Oct 2009 15:58:42 +0100

Amer J PerinatolDOI: 10.1055/s-0029-1239496ABSTRACTWe evaluated the effectiveness of sildenafil in the treatment of neonatal pulmonary hypertension. We performed a double-blind randomized clinical trial in 51 full-term infants with persistent pulmonary hypertension confirmed by Doppler echocardiography. Patients were divided in two groups: 20 infants in group A received placebo when the oxygenation index was >20, and 31 infants in group B received 3 mg/kg of oral sildenafil every 6 hours. Arterial blood gases were taken at 1, 4, 7, 13, 19, and 25 hours after treatment was started. Main outcome measures were oxygenation changes, time on mechanical ventilation, and mortality. Both groups were comparable in general variables as well as in illness severity. We observed better oxygenation pa...

Outcomes in Neonates with Gastroschisis in U.S. Children's Hospitals

American Journal of Perinatology — Thu, 29 Oct 2009 15:58:42 +0100

We examined descriptive characteristics and conducted multivariate regression models examining risk factors for mortality, during the birth hospitalization, and sepsis. Analysis of 2490 neonates with gastroschisis found 90 deaths (3.6%) and sepsis in 766 (31%). Critical comorbidities and procedures are cardiovascular defects (15%), pulmonary conditions (5%), intestinal atresia (11%), intestinal resection (12.5%), and ostomy formation (8.3%). Factors associated with mortality were large bowel resection (odds ratio [OR] 8.26, 95% confidence interval [CI] 1.17 to 58.17), congenital circulatory (OR 5.62, 95% CI 2.11 to 14.91), and pulmonary (OR 8.22, 95% CI 2.75 to 24.58) disease, and sepsis (OR 3.87, 95% CI 1.51 to 9.91). Factors associated with sepsis include intestinal ostomy (OR 2.94, 95% ...

Perinatal Neurofibromatosis: Two Case Reports and Review of the Literature

American Journal of Perinatology — Thu, 29 Oct 2009 02:52:17 +0100

Amer J PerinatolDOI: 10.1055/s-0029-1241737ABSTRACTNeurofibromatosis-1 (NF-1) is an autosomal-dominant genetic disorder with many different manifestations. Some may have evidence of the disease at birth. A 66-year (1942 to 2008) retrospective review of 36 patients including 7 fetuses and 29 neonates with NF-1 was performed. Only patients with NF-1 lesions detected before birth by imaging or noted in the first month of life were entered into the review. There was a strongly positive family history of the disease of 70%. The most common presenting findings in the fetus were hydrops, macrocephaly, and thickened neck soft tissues and those in the neonate were café au lait macules, skin nodules, and buphthalmos. Survivors developed serious sequelae (e.g., progressive growth of neurofibromas wi...

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Effect of Posture on Brain Hemodynamics in Preterm Newborns Not Mechanically Ventilated.

Neonatology — Thu, 29 Oct 2009 00:00:00 +0100

Conclusions: Hemodynamic changes after posture variations depend on GA. Head rotation in newborns with GA </=26 weeks produced a reduction in nTHI with stable TOI. Possible physiopathological mechanisms are discussed. PMID: 19887848 [PubMed - as supplied by publisher] (Source: Neonatology)

Overfeeding Can Cause NEC-Like Enterocolitis in Premature Rat Pups.

Neonatology — Thu, 29 Oct 2009 00:00:00 +0100

Conclusions: Increased expression of IkappaB-alpha/beta suggested that the inflammatory mediator nuclear factor-kappaB is deeply involved in the pathogenesis of enterocolitis that can be easily introduced by overfeeding of milk ingestion in premature rat pups which mimic those seen in NEC. Increased expression of PPAR-gamma may possibly regulate further development of enterocolitis in this system. PMID: 19887849 [PubMed - as supplied by publisher] (Source: Neonatology)

Is Screening for Renal Anomalies Warranted in Neonates with Isolated Single Umbilical Artery?

Neonatology — Thu, 29 Oct 2009 00:00:00 +0100

Conclusions: The prevalence of renal anomalies in neonates with isolated SUA is low. We suggest that routine ultrasound screening for renal anomalies is not warranted in neonates with isolated SUA. PMID: 19887850 [PubMed - as supplied by publisher] (Source: Neonatology)

Clara Cell Secretory Protein in Tracheobronchial Aspirates and Umbilical Cord Serum of Extremely Premature Infants with Systemic Inflammation.

Neonatology — Thu, 29 Oct 2009 00:00:00 +0100

Conclusions: Reduced anti-inflammatory CC10 concentrations in airways of extremely premature infants with a fetal inflammatory response might make their lungs susceptible for further postnatal injuries. Umbilical cord serum CC10 is not an indicator for a fetal systemic inflammatory reaction. PMID: 19887851 [PubMed - as supplied by publisher] (Source: Neonatology)

Characteristics of prospectively measured vaginal bleeding among women trying to conceive

Paediatric and Perinatal Epidemiology — Thu, 29 Oct 2009 00:00:00 +0100

Previous research has described variability in menstrual cycle lengths within and across women, though less attention has focused on characterising patterns of bleeding. While clinical definitions for menstrual bleeding are often given in standard textbooks, the validity of conventional definitions has not been empirically evaluated in epidemiological studies. The definition of menstrual bleeding may affect the analysis of time to pregnancy and pregnancy dating that relies upon the last menstrual period. We used daily records of vaginal bleeding from a prospective cohort study that included 74 women trying to become pregnant who reported 430 bleeding episodes. A longitudinal mixture model (PROC TRAJ) was used to classify patterns of bleeding. Among the first 74 bleeding episodes, 15% compr...

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Outcomes of early parenteral nutrition for premature infants

Journal of Perinatology — Thu, 29 Oct 2009 00:00:00 +0100

Authors: J Trintis, P Donohue & S Aucott (Source: Journal of Perinatology)

Quantitative Analysis of Amplitude-Integrated Electroencephalogram Patterns in Stable Preterm Infants, with Normal Neurological Development at One Year.

Neonatology — Wed, 28 Oct 2009 00:00:00 +0100

Conclusion: To our knowledge, this is the first study where aEEG development was studied by automated quantification of aEEG characteristics in a cohort of stable preterm infants with a normal neurological development at 1 year of age. LMA and DC-% are simple quantitative measures of neurophysiologic development and may be used to evaluate neurodevelopment in infants. PMID: 19864923 [PubMed - as supplied by publisher] (Source: Neonatology)

Pulmonary Vascular Endothelial Growth Factor Expression and Disaturated Phospholipid Content in a Chicken Model of Hypoxia-Induced Fetal Growth Restriction.

Neonatology — Wed, 28 Oct 2009 00:00:00 +0100

Conclusions: Both prenatal hypoxia and hyperoxia induced during critical windows of lung development differentially modulate surfactant synthesis. Our data support the concept that fetal oxygen tension is a key signal in the regulation of the surfactant system. PMID: 19864924 [PubMed - as supplied by publisher] (Source: Neonatology)

Long-Chain Polyunsaturated Fatty Acid Composition of Breast Milk in Pre-Eclamptic Mothers.

Neonatology — Wed, 28 Oct 2009 00:00:00 +0100

Conclusions: The data suggest that in pre-eclampsia, the relation between plasma and milk DHA is altered. The resulting higher milk DHA concentrations are beneficial for infants. PMID: 19864925 [PubMed - as supplied by publisher] (Source: Neonatology)

Cerebral Amino Acid Profiles after Hypoxia-Reoxygenation and N-Acetylcysteine Treatment in the Newborn Piglet.

Neonatology — Wed, 28 Oct 2009 00:00:00 +0100

Conclusions: In newborn piglets that have sustained brain injury related to hypoxia/reoxygenation, the administration of NAC does not disrupt cerebral amino acid balance and maintains cerebral amino acid homeostasis. PMID: 19864926 [PubMed - as supplied by publisher] (Source: Neonatology)

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Maternal Alcohol Intake and Offspring Pulse Wave Velocity.

Neonatology — Wed, 28 Oct 2009 00:00:00 +0100

Conclusions: Carotid-femoral PWV in adults is predictive of cardiovascular morbidity and mortality. The degree of continuity between childhood and adulthood PWV is unknown, but as we found an association between prenatal alcohol exposure and carotid-femoral PWV at 9 years, a permanent change in vessel wall structure or function is possible. These findings need to be confirmed in other and larger cohorts, and mechanistic animal studies are needed. PMID: 19864927 [PubMed - as supplied by publisher] (Source: Neonatology)

Radiological-Pathological Comparison in a Case of Conjoined Gnatho-Thoracopagus Twins

Fetal Diagnosis and Therapy — Tue, 27 Oct 2009 23:00:00 +0100

Fetal Diagn Ther (DOI:10.1159/000253879) (Source: Fetal Diagnosis and Therapy)

Perinatal Outcome of Monochorionic Twins with Selective Intrauterine Growth Restriction and Different Types of Umbilical Artery Doppler under Expectant Management

Fetal Diagnosis and Therapy — Tue, 27 Oct 2009 23:00:00 +0100

Fetal Diagn Ther (DOI:10.1159/000253880) (Source: Fetal Diagnosis and Therapy)

Chinese women's preferences for prenatal diagnostic procedure and their willingness to trade between procedures

Prenatal Diagnosis — Tue, 27 Oct 2009 00:00:00 +0100

To assess Chinese women's preference for the choice of a prenatal diagnosis test, karyotyping or rapid aneuploidy, and its relationship to maternal psychological state.Three hundred consenting women completed a self administered structured questionnaire which documented their psychological state and their preferred choice of diagnostic test for chromosomal abnormality using a discrete choice experiment design. Diagnostic tests were categorised according to three attributes: completeness of chromosomal information, procedure-to-result time interval and cost.Participants indicated a preference towards the karyotype test irrespective of cost and procedure-to-result time interval. The value of obtaining the extra information provided by karyotyping above that of rapid aneuploidy was £267.82 (...

First trimester pregnancy associated plasma protein-A as a marker for poor pregnancy outcome in patients with early-onset fetal growth restriction

Prenatal Diagnosis — Tue, 27 Oct 2009 00:00:00 +0100

To determine whether pregnancy associated plasma protein-A (PAPP-A) can be used to identify pregnancies at risk for poor perinatal outcomes among patients with second trimester fetal growth restriction (FGR).We analyzed outcomes for singleton pregnancies of patients with evidence of FGR in the second trimester who also had first trimester serum PAPP-A measured for aneuploidy risk assessment. We excluded pregnancies with aneuploidy, major anomalies, fetal infection, or second trimester premature rupture of membranes (PPROM).One hundred and ninety eight pregnancies with second trimester FGR and first trimester serum PAPP-A measurements were identified. PAPP-A below the fifth percentile was associated with an increased rate of third trimester SGA (50% vs 11%, p = 0.012), preterm birth (33.3% ...

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Use of array comparative genomic hybridization for prenatal diagnosis of fetuses with sonographic anomalies and normal metaphase karyotype

Prenatal Diagnosis — Tue, 27 Oct 2009 00:00:00 +0100

To prospectively study the addition of array comparative genomic hybridization (CGH) to the prenatal evaluation of fetal structural anomalies.Pregnant women carrying fetuses with a major structural abnormality were recruited at the time of invasive procedure for chromosome analysis. Only women whose fetuses had a normal karyotype (n = 50) were subsequently evaluated by array CGH using one of two arrays (1887 clones covering 622 loci or subsequently 4685 clones covering 1500 loci).The mean gestational age of the fetuses was 24.5 weeks (range 11-38 weeks). The most prevalent anomalies were cardiac, central nervous system, skeletal, and urogenital. The median turnaround time for culturing and array CGH diagnosis was 18 days (range 2-72). Four of 50 fetuses had abnormal array results. One (2%)...

Author and keyword index

Seminars in Fetal and Neonatal Medicine — Mon, 26 Oct 2009 16:31:50 +0100

(Source: Seminars in Fetal and Neonatal Medicine)

Title Page/Aims and Scope/Editorial Board

Seminars in Fetal and Neonatal Medicine — Mon, 26 Oct 2009 16:31:49 +0100

(Source: Seminars in Fetal and Neonatal Medicine)

N-Terminal Pro-Brain Natriuretic Peptide as a Biomarker for Hypertensive Disorders of Pregnancy

American Journal of Perinatology — Sun, 25 Oct 2009 15:46:08 +0100

Amer J PerinatolDOI: 10.1055/s-0029-1241735ABSTRACTWe tested the hypothesis that the cardiac biomarker N-terminal pro-brain natriuretic peptide would be elevated in hypertensive disorders of pregnancy, with an increase in levels of this biomarker across increasing gradations of disease severity. We performed a case-controlled study of women admitted to labor and delivery at the Hospital of the University of Pennsylvania between 24 and 42 weeks of gestation. Cases had hypertension that developed after 20 weeks of gestation, and controls were normotensive women presenting for delivery. N-terminal pro-brain natriuretic peptide levels were compared between cases ( = 83) and controls ( = 290). Cases were subclassified into gestational hypertension ( = 20) and...

MedWorm: Perinatology & Neonatology

First-trimester use of paroxetine and congenital heart defects: A population-based case-control study

Arterial Cord Blood Lactate at Birth Correlates with Duration of Pushing Efforts

Testing reported associations of genetic risk factors for oral clefts in a large Irish study population

Hypothesis: Could Epstein-Barr virus play a role in the development of gastroschisis?

Management of Pregnancy with Poor Intrauterine Fetal Growth

Intrauterine Growth Retardation: Clinical Problems in the Management of the Small-for-Date Baby

Pregnancy Outcome following Ultrasound Diagnosis of Fetal Urinary Tract Anomalies and/or Oligohydramnios

Is the Intrauterine Treatment of Fetal Hydrocephalus Helpful or Harmful?

Primates and Anencephalics as Sources for Pediatric Organ Transplants

Contents, Vol. 1, 1986

Editorial

Effect of Gestational Age on Fetal and Intervillous Blood Gas and Acid-Base Values in Human Pregnancy

Utero-Placental Blood Velocity Resistance Index and Umbilical Venous pO 2 , pCO 2 , pH, Lactate and Erythroblast Count in Growth-Retarded Fetuses

Intrauterine Exchange Transfusion of the Fetus under Ultrasound Guidance: First Successful Report

Rh Disease: Intravascular Fetal Blood Transfusion by Cordocentesis

Survival of Transfused Adult Cells in the Fetus

In utero Bladder Diversion -- Problems with Patient Selection

Fetal Hydrothorax in the Second Trimester of Pregnancy: Successful Intra-Uterine Treatment at 24 Weeks Gestation

Prenatal Diagnosis and Outcome of Congenital Complete Heart Block: The Role of Fetal Echocardiography

Bioethical Issues in Perinatology -- Is the Future Now?

Erratum

Author Index

Subject Index

Ambivalence toward undergoing invasive prenatal testing: an exploration of its origins

Contribution of MRI to Detect Further Anomalies in Fetal Ventriculomegaly

Review of perinatal management of arthrogryposis at a large UK teaching hospital serving a multiethnic population

Inter-laboratory control data for reproductive endpoints required in the OPPTS 870.3800/OECD 416 reproduction and fertility test

Is chorionic villus sampling associated with hypertensive disorders of pregnancy?

Maternal Plasma Fibronectin and Advanced Oxidative Protein Products for the Prediction of Preeclampsia in High Risk Pregnancies: A Prospective Cohort Study

Contents

Editorial Board

Transport of the Neonatal Patient With Persistent Pulmonary Hypertension

Neonatal Transport – A Family Support Module

The Impact of Air Ambulance Transport on Neonatal Outcomes

High-Fidelity Simulation for Transport Team Training and Competency Evaluation

Maturation of the Cardiac Response to Sound in High-Risk Preterm Infants

Obstacles in Providing Neonatal Care in Kurdistan, Iraq

Neonatal Transport: The Family Perspective

Neonatal Transport Crossword: (Multiple word answers include spaces between words)

News Flash

Guest Editorial

Editorial

Erratum

Ethics and “Cesarean Delivery on Maternal Demand”

Ethics Education in Neonatal-Perinatal Medicine in the United States

Ethics of Research in Perinatal Medicine

The Texas Advance Directives Act—Is It a Good Model?

Neonatal Euthanasia

Disputes Over Moral Standards Guiding Treatments for Imperiled Infants

Ethical Issues in Research Involving Infants

The Ethics of Newborn Resuscitation

Introduction: Taking the Time for Medical Ethics

Table of Contents

Topics for 2008

Masthead

Cover

Dietary selenium plus folic acid as an antioxidant therapy for ethanol-exposed pups

Influence of maternal BMI on genetic sonography in the FaSTER trial

Endoscopic laser coagulation following amnioreduction for the management of a large placental chorioangioma

Assessing the role of placental trisomy in preeclampsia and intrauterine growth restriction

Contemporary neonatal intensive care management in congenital diaphragmatic hernia: does this obviate the need for fetal therapy?

Determination of individual preference: why, how and alternatives

Rho proteins, pregnancy and labour

Diagnosis and management of selective fetal growth restriction in monochorionic twins

FMR volume 20 issue 4 Cover and Back matter

FMR volume 20 issue 4 Cover and Front matter

Acknowledgement

Index - Authors

Index - Subjects

Index Volume 37 (2009) - Contents

Congress Calendar

Emile Papiernik will stay alive in our thoughts

Breast feeding as human and divine nourishment

Congenital cataract with de novo balanced reciprocal t(3;13) (q23;q12) translocation in a newborn

Vanishing nuchal translucency syndrome

Diagnosis and treatment of maternal acute myeloid leukemia during pregnancy imitating HELLP syndrome

Obstetric outcomes of low-risk labors at ‘Japanese tatami’ mat delivery room: a preliminary study

Serum proinflammatory cytokine – interleukin-8 as possible infection site marker in preterm deliveries

Early enteral feeding in conservatively managed stage II necrotizing enterocolitis is associated with a reduced risk of catheter-related sepsis