MedWorm provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest medical blog items that have been tagged with 'adjuvant'. Sat, 03 Sep 2011 02:49:00 +0100 http://www.medworm.com/index.php?rid=4076860&cid=t_110584_139_f&fid=38879&url=http%3A%2F%2Fmedia.rawvoice.com%2Fpmn_twiv%2Ftraffic.libsyn.com%2Ftwiv%2FTWiV103.mp3 Hosts: Vincent Racaniello, Alan Dove, and LJ Tan On Episode 103 of the podcast This Week in Virology, Vincent and Alan discuss influenza vaccines with LJ Tan of the American Medical Association. Download TWiV #103 (56 MB .mp3, 77 minutes) Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio. Links for this episode: The American Medical Association Prevent Influenza Now Vaccine injury claim reaches Supreme Court Supreme Court divided on vaccine case No narcolepsy link to flu vaccine Letters read on TWiV 103 Weekly Science Picks Alan – BioGene, an iApp Vincent – The Vertical Farm by Dickson Despommier Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave ... virology blog blogs http://www.medworm.com/rss/comments.php?id=4076860 Sun, 17 Oct 2010 19:35:05 +0100 4076860 http://www.medworm.com/index.php?rid=3954263&cid=t_110584_87_f&fid=39260&url=http%3A%2F%2Fvaccineblogs.com%2Fresearch-synthetic-lipoid-compounds-dda%2F Step 1. Read about vaccine ingredient causing delayed-type hypersensitivity. “In 1966 Gall, in a survey of more than 100 chemicals, concluded that aliphatic compounds, containing 12 or more carbons in their chains, have outstanding adjuvant properties…Dimethyl-dioctadecyl ammonium bromide (DDA) is the only lipoid amine that has been extensively tested in many experimental systems and reviewed…In general DDA has proven to be very effective in inducing delayed-type hypersensitivity (DTH) (a marker for cell-mediated immunity (CMI)), humoral anditbodies and resistance to challenge with virulent viruses.” Stewart-Tull, D. (1995). The Theory and Practical Application of Adjuvants. pp 39-40 Step 2. Go to Toxnet. http://toxnet.nlm.nih.gov Slap in Dimethyl-dioctadecyl amm... Vaccine Blogs blogs http://www.medworm.com/rss/comments.php?id=3954263 Fri, 10 Sep 2010 05:06:00 +0100 3954263 http://www.medworm.com/index.php?rid=3016919&cid=t_110584_139_f&fid=38879&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FVirologyBlog%2F%7E3%2F_cPMuuWH1d0%2F Although the influenza 2009 H1N1 vaccine produced by Novartis, Fluvirin, was previously approved for use in the US, the clinical data supporting its safety and immunogenicity had not been released. The company has now issued a media release containing interim clinical data on the effects of the vaccine in humans. According to the company, testing of the vaccine in 4,080 adult and elderly (>65 years) US individuals has revealed that a half dose (3.75 micrograms) without adjuvant “fulfilled immune response criteria associated with protection”. I assume that the latter statement means that hemagglutination inhibition titers of 1:40 or greater were observed, but this is not explicitly stated.  Current US guidelines for the 2009 H1N1 2009 vaccine stipulate that adolescents, adul... virology blog blogs http://www.medworm.com/rss/comments.php?id=3016919 Wed, 18 Nov 2009 22:08:19 +0100 3016919 http://www.medworm.com/index.php?rid=3016922&cid=t_110584_139_f&fid=38879&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FVirologyBlog%2F%7E3%2FbhhPsUBNuM4%2F GlaxoSmithKline’s inactivated 2009 influenza H1N1 vaccine has been approved by the US Food & Drug Administration and by Health Canada. This action completes the list of pandemic H1N1 vaccines which I previously summarized for the US and Canada. Influenza A (H1N1) 2009 monovalent vaccine is produced by ID Biomedical Corporation of Quebec, a wholly-owned subsidiary of GlaxoSmithKline. The US package insert can be found here (pdf) and the Canadian package insert here. Dosing recommendations for Canada are listed here. Health Canada has also posted a FAQ on the H1N1 vaccine. The ID Biomedical vaccine is available only in multi-dose vials which contain thimerosal. Each 0.5 ml dose contains 15 micrograms of viral antigen. Other components of the vaccine listed at Health Canada include ... virology blog blogs http://www.medworm.com/rss/comments.php?id=3016922 Mon, 16 Nov 2009 15:24:08 +0100 3016922 http://www.medworm.com/index.php?rid=3016933&cid=t_110584_139_f&fid=38879&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FVirologyBlog%2F%7E3%2FnP-2UGV1rsc%2F The influenza A (H1N1) 2009 vaccine produced by GlaxoSmithKline has been approved by Canada Health. Here is some information on the vaccine to supplement what I’ve provided about the US counterparts. The Canadian vaccine, called Arepanrix H1N1, is supplied in two parts. One contains inactivated H1N1 influenza virus, and the second consists of AS03 adjuvant (DL-a-tocopherol, squalene, polysorbate 80). Before injection the virus and adjuvant are mixed. The vaccine is provided in 10-dose vials and therefore contains thimerosal. More information on the amounts of these components can be found at the Canada Health website (”Product Information Leaflet Arepanrix™ H1N1 AS03-Adjuvanted H1N1 Pandemic Influenza Vaccine”). Health Canada approved the vaccine based on limited clinic... virology blog blogs http://www.medworm.com/rss/comments.php?id=3016933 Thu, 22 Oct 2009 21:51:19 +0100 3016933 http://www.medworm.com/index.php?rid=2812262&cid=t_110584_139_f&fid=38879&url=http%3A%2F%2Fmedia.rawvoice.com%2Fpmn_twiv%2Fwww.twiv.tv%2FTWiV050.mp3 Hosts: Vincent Racaniello and Jason Rodriguez On episode #50 of the podcast “This Week in Virology”, Vincent and Jason review influenza 2009 H1N1 vaccine trials and protection against the virus conferred by the 1976 swine flu vaccine, then move on to a virus called XMRV and its possible role in prostate cancer. Download TWiV #50 (54 MB .mp3, 74 minutes) Subscribe to TWiV in iTunes, by the RSS feed, or by email Links for this episode: One dose of influenza 2009 H1N1 vaccine without adjuvant is enough Partially completed study on influenza 2009 H1N1 vaccine with MF59 adjuvant 1976 swine flu vaccine induces cross-reactive antibodies against influenza 2009 H1N1 strain Explanation of hemagglutination-inhibition and microneutralization assays FDA approves influenza 2009 H1N1 vaccine... virology blog blogs http://www.medworm.com/rss/comments.php?id=2812262 Sun, 20 Sep 2009 14:04:12 +0100 2812262 http://www.medworm.com/index.php?rid=2757384&cid=t_110584_139_f&fid=38879&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FVirologyBlog%2F%7E3%2FvXxeKrVVsmA%2F There has been a great deal of discussion about the use of adjuvants to improve the immunogenicity of vaccines against the 2009 H1N1 pandemic influenza strain. What effect do these compounds have on the immune response? Adjuvants are compounds added to vaccines that stimulate the immune response. They are often used when the antigen is in short supply, or does not induce a good antibody response. Because the 2009 H1N1 pandemic influenza strains do not replicate well in eggs, it has been suggested that adjuvants be used to ensure that there is sufficient supply of vaccine. A recent study demonstrates very clearly the effect of adjuvants on the immune response. Mice were immunized with egg-produced 2009 H1N1 influenza vaccine with or without the adjuvant MF59. A boost inoculation was given o... virology blog blogs http://www.medworm.com/rss/comments.php?id=2757384 Wed, 02 Sep 2009 03:16:11 +0100 2757384 http://www.medworm.com/index.php?rid=589131&cid=t_110584_87_f&fid=34865&url=http%3A%2F%2Fwww.thecancerblog.com%2F2007%2F05%2F04%2Flocally-advanced-breast-cancer-chemo-before-surgery%2F Filed under: Breast Cancer, Drug, Chemotherapy, Clinical Trials, Research, SurgeryChemotherapy given before surgery to remove cancer is called neoadjuvant treatment. An oncologist might recommend this based of the size of the tumor -- it being very large. The idea is to shrink the tumor and then have surgery to remove the cancer. Having chemotherapy administered while the tumor is still there can show what drugs are working and what drugs have no effect on the tumor. Chemotherapy when started immediately, not after surgery with healing time needed, gives the patient systematic treatment right away. This could be beneficial and is why physicians might recommend this form of treatment. The truth is they don't know if it is better or not. Of course, every case of breast cancer is different. W... The Cancer Blog blogs http://www.medworm.com/rss/comments.php?id=589131 Fri, 04 May 2007 04:00:00 +0100 589131 http://www.medworm.com/index.php?rid=528057&cid=t_110584_87_f&fid=34865&url=http%3A%2F%2Fwww.thecancerblog.com%2F2007%2F04%2F07%2Fchemo-plus-tamoxifen-a-go-ovary-suppression-a-no%2F Filed under: Breast Cancer, Chemotherapy, Research, Daily newsResults of two studies, sponsored by the Adjuvant Breast Cancer (ABC) Trials Collaborative Group, conclude that adding chemotherapy to the estrogen-blocking drug tamoxifen improves survival for those with early-stage breast cancer. The same studies reveal preventing the secretion of estrogen from the ovaries does not offer much benefit for most women.Researchers studied 1991 patients, ages 28 to 81. All had received five years worth of treatment with tamoxifen therapy with or without standard chemotherapy. Some premenopausal women were also treated with ovarian removal (ablation) or suppression, a technique used to stop the glands from secreting hormones.While early results, appearing in the Journal of the National Cancer Instit... The Cancer Blog blogs http://www.medworm.com/rss/comments.php?id=528057 Sat, 07 Apr 2007 04:00:00 +0100 528057